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Jessica Van Ziffle, PhD

Title(s)Associate Professor, Pathology
SchoolSchool of Medicine
Address2340 Sutter Street
San Francisco CA 94115
Phone415-502-3252
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Clinicopathologic and molecular features of intracranial desmoplastic small round cell tumors. Brain Pathol. 2020 03; 30(2):213-225. Lee JC, Villanueva-Meyer JE, Ferris SP, Cham EM, Zucker J, Cooney T, Gilani A, Kleinschmidt-DeMasters BK, Trembath D, Mafra M, Chiang J, Ellison DW, Cho SJ, Horvai AE, Van Ziffle J, Onodera C, Devine P, Grenert JP, de Voijs CMA, van Blokland WTM, de Leng WWJ, Ploegmakers MJ, Flucke U, Pekmezci M, Bollen AW, Tihan T, Koelsche C, von Deimling A, Wesseling P, Solomon DA, Perry A. PMID: 31837177.
      View in: PubMed   Mentions:    Fields:    
    2. A novel truncating variant in ring finger protein 113A (RNF113A) confirms the association of this gene with X-linked trichothiodystrophy. . 2020 03; 182(3):513-520. Mendelsohn BA, Beleford DT, Abu-El-Haija A, Alsaleh NS, Rahbeeni Z, Martin PM, Rego S, Huang A, Capodanno G, Shieh JT, Van Ziffle J, Risch N, Alkuraya FS, Slavotinek AM. PMID: 31880405.
      View in: PubMed   Mentions:
    3. Myxoid glioneuronal tumor, PDGFRA p.K385-mutant: clinical, radiologic, and histopathologic features. Brain Pathol. 2020 05; 30(3):479-494. Lucas CG, Villanueva-Meyer JE, Whipple N, Oberheim Bush NA, Cooney T, Chang S, McDermott M, Berger M, Cham E, Sun PP, Putnam A, Zhou H, Bollo R, Cheshier S, Poppe MM, Fung KM, Sung S, Glenn C, Fan X, Bannykh S, Hu J, Danielpour M, Li R, Alva E, Johnston J, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA. PMID: 31609499.
      View in: PubMed   Mentions: 1     Fields:    
    4. Fusion driven JMML: a novel CCDC88C-FLT3 fusion responsive to sorafenib identified by RNA sequencing. Leukemia. 2020 02; 34(2):662-666. Chao AK, Meyer JA, Lee AG, Hecht A, Tarver T, Van Ziffle J, Koegel AK, Golden C, Braun BS, Sweet-Cordero EA, Smith CC, Dvorak CC, Loh ML, Stieglitz E. PMID: 31511612.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas. Acta Neuropathol. 2019 11; 138(5):877-881. Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA. PMID: 31515627.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    6. Hormone receptor expression of colorectal cancer diagnosed during the peri-partum period. Endocr Connect. 2019 Aug; 8(8):1149-1158. Silverstein J, Kidder W, Fisher S, Hope TA, Maisel S, Ng D, Van Ziffle J, Atreya CE, Van Loon K. PMID: 31370007.
      View in: PubMed   Mentions:
    7. TP53 structural variants in metastatic prostatic carcinoma. PLoS One. 2019; 14(6):e0218618. Sirohi D, Devine P, Grenert JP, van Ziffle J, Simko JP, Stohr BA. PMID: 31216325.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis. Brain Pathol. 2020 01; 30(1):46-62. Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA. PMID: 31104347.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1. Acta Neuropathol. 2019 03; 137(3):521-525. Lee JC, Villanueva-Meyer JE, Ferris SP, Sloan EA, Hofmann JW, Hattab EM, Williams BJ, Guo H, Torkildson J, Florez A, Van Ziffle J, Onodera C, Grenert JP, Cho SJ, Horvai AE, Jones DTW, Pfister SM, Koelsche C, von Deimling A, Korshunov A, Perry A, Solomon DA. PMID: 30649606.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. CRTC1-MAML2 fusion in mucoepidermoid carcinoma of the breast. Histopathology. 2019 Feb; 74(3):463-473. Bean GR, Krings G, Otis CN, Solomon DA, García JJ, van Zante A, Camelo-Piragua S, van Ziffle J, Chen YY. PMID: 30380176.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. Brain Pathol. 2019 01; 29(1):85-96. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh JTC, Solomon DA. PMID: 30051528.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    12. Oligodendrogliomas, IDH-mutant and 1p/19q-codeleted, arising during teenage years often lack TERT promoter mutation that is typical of their adult counterparts. Acta Neuropathol Commun. 2018 09 19; 6(1):95. Lee J, Putnam AR, Chesier SH, Banerjee A, Raffel C, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Perry A, Solomon DA. PMID: 30231927.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    13. The genetic landscape of gliomas arising after therapeutic radiation. Acta Neuropathol. 2019 01; 137(1):139-150. López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C, Gupta N, Kunwar S, Mummaneni P, Aghi M, Theodosopoulos P, Berger M, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA. PMID: 30196423.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42. Mod Pathol. 2019 01; 32(1):88-99. Stevers M, Rabban JT, Garg K, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Zaloudek C, Solomon DA. PMID: 30171198.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    15. Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile. Acta Neuropathol. 2018 08; 136(2):339-343. Solomon DA, Korshunov A, Sill M, Jones DTW, Kool M, Pfister SM, Fan X, Bannykh S, Hu J, Danielpour M, Li R, Johnston J, Cham E, Cooney T, Sun PP, Oberheim Bush NA, McDermott M, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Villanueva-Meyer JE, Pekmezci M, Bollen AW, Perry A. PMID: 30006677.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    16. The genetic landscape of ganglioglioma. Acta Neuropathol Commun. 2018 06 07; 6(1):47. Pekmezci M, Villanueva-Meyer JE, Goode B, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Chamyan G, Maher OM, Khatib Z, Kleinschmidt-DeMasters BK, Samuel D, Mueller S, Banerjee A, Clarke JL, Cooney T, Torkildson J, Gupta N, Theodosopoulos P, Chang EF, Berger M, Bollen AW, Perry A, Tihan T, Solomon DA. PMID: 29880043.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    17. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA. PMID: 29476136.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    18. Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation. Acta Neuropathol. 2018 04; 135(4):635-638. Iorgulescu JB, Van Ziffle J, Stevers M, Grenert JP, Bastian BC, Chavez L, Stichel D, Buchhalter I, Samuel D, Nicolaides T, Banerjee A, Mueller S, Gupta N, Tihan T, Bollen AW, Northcott PA, Kool M, Pfister S, Korshunov A, Perry A, Solomon DA. PMID: 29435664.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    19. Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway. Acta Neuropathol. 2018 03; 135(3):485-488. Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA. PMID: 29428973.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    20. Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Mod Pathol. 2018 04; 31(4):660-673. Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian BC, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon DA. PMID: 29148537.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    21. Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex. Acta Neuropathol. 2017 Oct; 134(4):671-673. Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert JP, Kline CN, Tihan T, Perry A, Gupta N, Solomon DA. PMID: 28776091.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Acute myeloid leukemia with t(14;21) involving RUNX1 and SYNE2: A novel favorable-risk translocation? Cancer Genet. 2017 Oct; 216-217:74-78. Foley N, Van Ziffle J, Yu J, Qi Z, Grenert JP, Yeh I, Bastian B, Kogan S, Mannis GN. PMID: 29025598.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. Pierpont syndrome associated with the p.Tyr446Cys missense mutation in TBL1XR1. Eur J Med Genet. 2017 Oct; 60(10):504-508. Slavotinek A, Pua H, Hodoglugil U, Abadie J, Shieh J, Van Ziffle J, Kvale M, Lee H, Kwok PY, Risch N, Sabbadini M. PMID: 28687524.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    24. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 05 01; 19(5):699-709. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. PMID: 28453743.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    25. Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation. Acta Neuropathol. 2016 11; 132(5):757-760. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT. PMID: 27624885.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    26. Genomic profiling of malignant phyllodes tumors reveals aberrations in FGFR1 and PI-3 kinase/RAS signaling pathways and provides insights into intratumoral heterogeneity. Mod Pathol. 2016 09; 29(9):1012-27. Liu SY, Joseph NM, Ravindranathan A, Stohr BA, Greenland NY, Vohra P, Hosfield E, Yeh I, Talevich E, Onodera C, Van Ziffle JA, Grenert JP, Bastian BC, Chen YY, Krings G. PMID: 27255162.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    27. Constitutional MLH1 methylation presenting with colonic polyposis syndrome and not Lynch syndrome. Fam Cancer. 2016 Apr; 15(2):275-80. Kidambi TD, Blanco A, Van Ziffle J, Terdiman JP. PMID: 26781822.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas. Neuro Oncol. 2016 05; 18(5):752-3. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Yeh I, Bastian BC, Mueller S, Solomon DA. PMID: 26902849.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    29. KRAS insertion mutations are oncogenic and exhibit distinct functional properties. Nat Commun. 2016 Feb 08; 7:10647. White Y, Bagchi A, Van Ziffle J, Inguva A, Bollag G, Zhang C, Carias H, Dickens D, Loh M, Shannon K, Firestone AJ. PMID: 26854029.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    30. A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma. Clin Cancer Res. 2016 Jan 01; 22(1):61-8. Ko AH, Bekaii-Saab T, Van Ziffle J, Mirzoeva OM, Joseph NM, Talasaz A, Kuhn P, Tempero MA, Collisson EA, Kelley RK, Venook AP, Dito E, Ong A, Ziyeh S, Courtin R, Linetskaya R, Tahiri S, Korn WM. PMID: 26251290.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCellsCTClinical Trials
    31. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3311-20. Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA. PMID: 23940344.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    32. Deletion of Syk in neutrophils prevents immune complex arthritis. J Immunol. 2011 Oct 15; 187(8):4319-30. Elliott ER, Van Ziffle JA, Scapini P, Sullivan BM, Locksley RM, Lowell CA. PMID: 21918195.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    33. Homozygous deletion of six olfactory receptor genes in a subset of individuals with Beta-thalassemia. PLoS One. 2011 Feb 24; 6(2):e17327. Van Ziffle J, Yang W, Chehab FF. PMID: 21390308.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    34. Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest. 2009 Nov; 119(11):3450-61. Looney MR, Nguyen JX, Hu Y, Van Ziffle JA, Lowell CA, Matthay MA. PMID: 19809160.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    35. Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection. Blood. 2009 Nov 26; 114(23):4871-82. Van Ziffle JA, Lowell CA. PMID: 19797524.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    36. Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. J Leukoc Biol. 2008 Oct; 84(4):1141-50. Paul R, Obermaier B, Van Ziffle J, Angele B, Pfister HW, Lowell CA, Koedel U. PMID: 18625913.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    37. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006 Aug; 25(2):271-83. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN. PMID: 16872848.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    38. Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo. Blood. 2006 Sep 15; 108(6):2041-4. Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K. PMID: 16720837.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    39. Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J Clin Invest. 2006 Jun; 116(6):1615-23. Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA. PMID: 16710475.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    40. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6158-63. Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC. PMID: 15073337.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    41. Telomere length in subpopulations of human hematopoietic cells. Stem Cells. 2003; 21(6):654-60. Van Ziffle JA, Baerlocher GM, Lansdorp PM. PMID: 14595125.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    42. Structure and evolution of 4-coumarate:coenzyme A ligase (4CL) gene families. Biol Chem. 2001 Apr; 382(4):645-54. Cukovic D, Ehlting J, VanZiffle JA, Douglas CJ. PMID: 11405227.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
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