 James Lee, MD
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| Title(s) | CLINICAL FELLOW, Medicine |
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| School | School of Medicine |
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| Address | Location Required
Varies CA 00000
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| Phone | 415-885-7276 |
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| vCard | Download vCard |
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 Biography | 2006
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| 2007 | American Medical Association Seed Grant | | 2006
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| 2007 | American Society of Hematology Trainee Award | | 2007
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| 2008 | Farr Scholar Award for Leadership and Excellence in Biomedical Research, Yale University | | 2008
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| 2009 | American Cancer Society of Connecticut Research Award | | 2016
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| 2017 | NIH Immunology T32 | | 2017
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| 2020 | A.P. Giannini Fellowship Award | | 2019
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| 2021 | Parker Institute for Cancer Immunotherapy Project Award |
Overview I have a research focus in adoptive T cell therapy using chimeric antigen receptors (CARs) and checkpoint inhibitors. My current interest is on the design of next generation of CARs and combination checkpoint immunotherapy in the setting of a tolerant/suppressive tumor microenvironment in solid malignancies.
Translating recent advancements in cellular cancer immunotherapy to metastatic solid tumors has been especially challenging, and this is highlighted by the lack clinical response outside of the CD19 ideal antigen as target. Current forms of therapy is likely insufficient to overcome the naturally tolerogenic microenvironment evolved to protect against autoimmunity. Using the liver as a model organ of immune tolerance, I intend to study the mechanism of tumor escape in the setting of checkpoint inhibition and adoptive T cell therapy.
My hope is to see cancer immunotherapeutics become its own mainstream anatomic-site agnostic cancer subspecialty.
Professional Experience:
Clinical Instructor, Memorial Sloan-Kettering Cancer Center, New York, NY. July 2012-July 2013
Clinical Instructor, University of California, San Francisco, CA. July 2013-July 2014
Education:
Medical School: Yale School of Medicine, New Haven, CT. September 2003-May 2009
Research Fellowship: Memorial Sloan-Kettering Cancer Center, New York, NY. 2006-2009.
Residency: Mount Sinai Medical Center, New York, NY. July 2009-June 2012
Bibliographic
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
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Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis. Science Immunology. 2020; PMID: 33008914.
View Publication.
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Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors. Diabetes. 2018 08; 67(8):1471-1480.
Stamatouli AM, Quandt Z, Perdigoto AL, Clark PL, Kluger H, Weiss SA, Gettinger S, Sznol M, Young A, Rushakoff R, Lee J, Bluestone JA, Anderson M, Herold KC. PMID: 29937434.
View in: PubMed Mentions: 41 Fields: Translation: HumansAnimals
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Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy. JCI Insight. 2017 Jul 20; 2(14).
Loo K, Tsai KK, Mahuron K, Liu J, Pauli ML, Sandoval PM, Nosrati A, Lee J, Chen L, Hwang J, Levine LS, Krummel MF, Algazi AP, Pampaloni M, Alvarado MD, Rosenblum MD, Daud AI. PMID: 28724802.
View in: PubMed Mentions: 12 Fields:
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Shifting the Evolving CAR T Cell Platform into Higher Gear. Cancer Cell. 2015 Oct 12; 28(4):401-402.
Holohan DR, Lee JC, Bluestone JA. PMID: 26461084.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood. 2012; 18(119):4133-41.
Lee JC*, Pegram HJ*, Hayman EG, Imperato GH, Tedder TF, Sadelain M, Brentjens RJ .View Publication.
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In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy. Cancer Res. 2011 Apr 15; 71(8):2871-81.
Lee JC, Hayman E, Pegram HJ, Santos E, Heller G, Sadelain M, Brentjens R. PMID: 21487038.
View in: PubMed Mentions: 34 Fields: Translation: HumansAnimalsCells
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Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase. Nat Med. 2009 Mar; 15(3):338-44.
Santos EB, Yeh R, Lee J, Nikhamin Y, Punzalan B, Punzalan B, La Perle K, Larson SM, Sadelain M, Brentjens RJ. PMID: 19219023.
View in: PubMed Mentions: 59 Fields: Translation: HumansAnimalsCells
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Retroviral transduction of murine primary T lymphocytes. Methods Mol Biol. 2009; 506:83-96.
Lee J, Sadelain M, Brentjens R. PMID: 19110621.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Inventing New CARs: Analysis of Chimeric Antigen Receptor Gene-Targeted T cells Modified to Overcome Regulatory T cell Suppression in the Tumor Microenvironment. Yale University MD Thesis. 2009.
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| Year | Publications |
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| 2009 | 2 | | 2011 | 1 | | 2012 | 1 | | 2015 | 1 | | 2017 | 1 | | 2018 | 1 | | 2020 | 1 |
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This graph shows the number and percent of publications by field.
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