James Lee, MD

Title(s)CLINICAL FELLOW, Medicine
SchoolSchool of Medicine
Address550 16th Street
San Francisco CA 94158
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    Collapse Biography 
    Collapse Awards and Honors
    2006  - 2007American Medical Association Seed Grant
    2006  - 2007American Society of Hematology Trainee Award
    2007  - 2008Farr Scholar Award for Leadership and Excellence in Biomedical Research, Yale University
    2008  - 2009American Cancer Society of Connecticut Research Award
    2016  - 2017NIH Immunology T32
    2017  - 2020A.P. Giannini Fellowship Award
    2019  - 2021Parker Institute for Cancer Immunotherapy Project Award

    Collapse Overview 
    Collapse Overview
    I have a research focus in adoptive T cell therapy using chimeric antigen receptors (CARs) and checkpoint inhibitors. My current interest is on the design of next generation of CARs and combination checkpoint immunotherapy in the setting of a tolerant/suppressive tumor microenvironment in solid malignancies.

    Translating recent advancements in cellular cancer immunotherapy to metastatic solid tumors has been especially challenging, and this is highlighted by the lack clinical response outside of the CD19 ideal antigen as target. Current forms of therapy is likely insufficient to overcome the naturally tolerogenic microenvironment evolved to protect against autoimmunity. Using the liver as a model organ of immune tolerance, I intend to study the mechanism of tumor escape in the setting of checkpoint inhibition and adoptive T cell therapy.

    My hope is to see cancer immunotherapeutics become its own mainstream anatomic-site agnostic cancer subspecialty.

    Professional Experience:

    Clinical Instructor, Memorial Sloan-Kettering Cancer Center, New York, NY. July 2012-July 2013

    Clinical Instructor, University of California, San Francisco, CA. July 2013-July 2014


    Medical School: Yale School of Medicine, New Haven, CT. September 2003-May 2009

    Research Fellowship: Memorial Sloan-Kettering Cancer Center, New York, NY. 2006-2009.

    Residency: Mount Sinai Medical Center, New York, NY. July 2009-June 2012

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis. Science Immunology. 2020; PMID: 33008914. View Publication.
    2. Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors. Diabetes. 2018 08; 67(8):1471-1480. Stamatouli AM, Quandt Z, Perdigoto AL, Clark PL, Kluger H, Weiss SA, Gettinger S, Sznol M, Young A, Rushakoff R, Lee J, Bluestone JA, Anderson M, Herold KC. PMID: 29937434.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimals
    3. Partially exhausted tumor-infiltrating lymphocytes predict response to combination immunotherapy. JCI Insight. 2017 Jul 20; 2(14). Loo K, Tsai KK, Mahuron K, Liu J, Pauli ML, Sandoval PM, Nosrati A, Lee J, Chen L, Hwang J, Levine LS, Krummel MF, Algazi AP, Pampaloni M, Alvarado MD, Rosenblum MD, Daud AI. PMID: 28724802.
      View in: PubMed   Mentions: 19     Fields:    
    4. Shifting the Evolving CAR T Cell Platform into Higher Gear. Cancer Cell. 2015 Oct 12; 28(4):401-402. Holohan DR, Lee JC, Bluestone JA. PMID: 26461084.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    5. Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning. Blood. 2012; 18(119):4133-41. Lee JC*, Pegram HJ*, Hayman EG, Imperato GH, Tedder TF, Sadelain M, Brentjens RJ . View Publication.
    6. In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy. Cancer Res. 2011 Apr 15; 71(8):2871-81. Lee JC, Hayman E, Pegram HJ, Santos E, Heller G, Sadelain M, Brentjens R. PMID: 21487038.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    7. Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase. Nat Med. 2009 Mar; 15(3):338-44. Santos EB, Yeh R, Lee J, Nikhamin Y, Punzalan B, Punzalan B, La Perle K, Larson SM, Sadelain M, Brentjens RJ. PMID: 19219023.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    8. Retroviral transduction of murine primary T lymphocytes. Methods Mol Biol. 2009; 506:83-96. Lee J, Sadelain M, Brentjens R. PMID: 19110621.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    9. Inventing New CARs: Analysis of Chimeric Antigen Receptor Gene-Targeted T cells Modified to Overcome Regulatory T cell Suppression in the Tumor Microenvironment. Yale University MD Thesis. 2009.
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