Matthew Spitzer, PhD

Title(s)Associate Professor, Otolaryngology
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSW, #1501A
San Francisco CA 94143
PronounsHe/Him/His
ORCID ORCID Icon0000-0002-5291-3819 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityPhDImmunology
    Georgetown UniversityBSBiology

    Collapse Overview 
    Collapse Overview
    The Spitzer Lab is working to develop our understanding of how the immune system coordinates its responses across the organism with an emphasis on tumor immunology. We combine methods in experimental immunology and cancer biology with computation to understand the modes in which the immune system can respond to tumors and to rationally initiate curative immune responses against cancer.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Single-cell High-dimensional Characterization of the Bone Marrow Microenvironment in Health and Disease
    NIH R21AG057224Jul 15, 2017 - May 31, 2019
    Role: Co-Principal Investigator
    Quantitatively modeling immune responses to cancer
    NIH DP5OD023056Sep 21, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Revealing the tumor-immune network by mass cytometry
    NIH F31CA189331Sep 30, 2014 - Sep 29, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A mass cytometry method pairing T cell receptor and differentiation state analysis. Nat Immunol. 2024 Sep; 25(9):1754-1763. Garcia Castillo J, DeBarge R, Mende A, Tenvooren I, Marquez DM, Straub A, Busch DH, Spitzer MH, DuPage M. PMID: 39191945.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. A Wireless, Multicolor Fluorescence Image Sensor Implant for Real-Time Monitoring in Cancer Therapy. ArXiv. 2024 Jun 27. Roschelle M, Rabbani R, Gweon S, Kumar R, Vercruysse A, Cho NW, Spitzer MH, Niknejad AM, Stojanovic VM, Anwar M. PMID: 38979489; PMCID: PMC11230517.
      View in: PubMed   Mentions:
    3. Author Correction: Systemic dysfunction and plasticity of the immune macroenvironment in cancer models. Nat Med. 2024 May; 30(5):1502. Allen BM, Hiam KJ, Burnett CE, Venida A, DeBarge R, Tenvooren I, Marquez DM, Cho NW, Carmi Y, Spitzer MH. PMID: 38565647.
      View in: PubMed   Mentions:    Fields:    
    4. Enhancing CAR-T cell metabolism to overcome hypoxic conditions in the brain tumor microenvironment. JCI Insight. 2024 Apr 08; 9(7). Hatae R, Kyewalabye K, Yamamichi A, Chen T, Phyu S, Chuntova P, Nejo T, Levine LS, Spitzer MH, Okada H. PMID: 38386420; PMCID: PMC11128202.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Disrupting CD38-driven T cell dysfunction restores sensitivity to cancer immunotherapy. bioRxiv. 2024 Mar 26. Revach OY, Cicerchia AM, Shorer O, Petrova B, Anderson S, Park J, Chen L, Mehta A, Wright SJ, McNamee N, Tal-Mason A, Cattaneo G, Tiwari P, Xie H, Sweere JM, Cheng LC, Sigal N, Enrico E, Miljkovic M, Evans SA, Nguyen N, Whidden ME, Srinivasan R, Spitzer MH, Sun Y, Sharova T, Lawless AR, Michaud WA, Rasmussen MQ, Fang J, Palin CA, Chen F, Wang X, Ferrone CR, Lawrence DP, Sullivan RJ, Liu D, Sachdeva UM, Sen DR, Flaherty KT, Manguso RT, Bod L, Kellis M, Boland GM, Yizhak K, Yang J, Kanarek N, Sade-Feldman M, Hacohen N, Jenkins RW. PMID: 38405985; PMCID: PMC10888727.
      View in: PubMed   Mentions:
    6. The tumor microenvironment of benign and malignant salivary gland tumors. Head Neck. 2024 07; 46(7):1625-1636. Wai KC, Okholm TLH, Ha PK, Marquez DM, Tenvooren I, Jones KB, Spitzer MH. PMID: 38454566.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Lower frequencies of circulating suppressive regulatory T cells and higher frequencies of CD4+ naïve T cells at baseline are associated with severe immune-related adverse events in immune checkpoint inhibitor-treated melanoma. J Immunother Cancer. 2024 01 17; 12(1). Kovacsovics-Bankowski M, Sweere JM, Healy CP, Sigal N, Cheng LC, Chronister WD, Evans SA, Marsiglio J, Gibson B, Swami U, Erickson-Wayman A, McPherson JP, Derose YS, Eliason AL, Medina CO, Srinivasan R, Spitzer MH, Nguyen N, Hyngstrom J, Hu-Lieskovan S. PMID: 38233101; PMCID: PMC10806651.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. A mass cytometry approach to track the evolution of T cell responses during infection and immunotherapy by paired T cell receptor repertoire and T cell differentiation state analysis. bioRxiv. 2024 Jan 12. Castillo JG, DeBarge R, Mende A, Tenvooren I, Marquez DM, Straub A, Busch DH, Spitzer MH, DuPage M. PMID: 38260336; PMCID: PMC10802618.
      View in: PubMed   Mentions:
    9. Epigenetic reprogramming shapes the cellular landscape of schwannoma. Nat Commun. 2024 Jan 12; 15(1):476. Liu SJ, Casey-Clyde T, Cho NW, Swinderman J, Pekmezci M, Dougherty MC, Foster K, Chen WC, Villanueva-Meyer JE, Swaney DL, Vasudevan HN, Choudhury A, Pak J, Breshears JD, Lang UE, Eaton CD, Hiam-Galvez KJ, Stevenson E, Chen KH, Lien BV, Wu D, Braunstein SE, Sneed PK, Magill ST, Lim D, McDermott MW, Berger MS, Perry A, Krogan NJ, Hansen MR, Spitzer MH, Gilbert L, Theodosopoulos PV, Raleigh DR. PMID: 38216587; PMCID: PMC10786948.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. The lncRNA Malat1 inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formation. Elife. 2023 Dec 21; 12. Wheeler BD, Gagnon JD, Zhu WS, Muñoz-Sandoval P, Wong SK, Simeonov DS, Li Z, DeBarge R, Spitzer MH, Marson A, Ansel KM. PMID: 38127070; PMCID: PMC10735224.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    11. Single cell proteomics characterization of bone marrow hematopoiesis with distinct Ras pathway lesions. bioRxiv. 2023 Dec 20. Karra L, Finger AM, Shechtman L, Krush M, Huang RM, Prinz M, Tennvooren I, Bahl K, Hysienaj L, Gonzalez PG, Combes AJ, Gonzalez H, Argüello RJ, Spitzer MH, Roose JP. PMID: 38187679; PMCID: PMC10769276.
      View in: PubMed   Mentions:
    12. Enhancing CAR-T Cell Metabolism to Overcome Hypoxic Conditions in the Brain Tumor Microenvironment. bioRxiv. 2023 Nov 15. Hatae R, Kyewalabye K, Yamamichi A, Chen T, Phyu S, Chuntova P, Nejo T, Levine LS, Spitzer MH, Okada H. PMID: 38014236; PMCID: PMC10680638.
      View in: PubMed   Mentions:
    13. Commensal myeloid crosstalk in neonatal skin regulates long-term cutaneous type 17 inflammation. bioRxiv. 2023 Oct 02. Dhariwala MO, DeRogatis AM, Okoro JN, Weckel A, Tran VM, Habrylo I, Ojewumi OT, Tammen AE, Leech JM, Merana GR, Carale RO, Barrere-Cain R, Hiam-Galvez KJ, Spitzer MH, Scharschmidt TC. PMID: 37873143; PMCID: PMC10592812.
      View in: PubMed   Mentions:
    14. Simvastatin induces human gut bacterial cell surface genes. Mol Microbiol. 2023 Sep 15. Escalante V, Nayak RR, Noecker C, Babdor J, Spitzer M, Deutschbauer AM, Turnbaugh PJ. PMID: 37712143; PMCID: PMC10940213.
      View in: PubMed   Mentions: 1     Fields:    
    15. The lncRNA Malat1 Inhibits miR-15/16 to Enhance Cytotoxic T Cell Activation and Memory Cell Formation. bioRxiv. 2023 Jul 29. Wheeler BD, Gagnon JD, Zhu WS, Muñoz-Sandoval P, Wong SK, Simeonov DR, Li Z, Debarge R, Spitzer MH, Marson A, Ansel KM. PMID: 37547023; PMCID: PMC10401941.
      View in: PubMed   Mentions:
    16. Computational Methods for Single-Cell Proteomics. Annu Rev Biomed Data Sci. 2023 08 10; 6:47-71. Guldberg SM, Okholm TLH, McCarthy EE, Spitzer MH. PMID: 37040735; PMCID: PMC10621466.
      View in: PubMed   Mentions:    Fields:    
    17. Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes. Cell. 2023 03 16; 186(6):1127-1143.e18. Rahim MK, Okholm TLH, Jones KB, McCarthy EE, Liu CC, Yee JL, Tamaki SJ, Marquez DM, Tenvooren I, Wai K, Cheung A, Davidson BR, Johri V, Samad B, O'Gorman WE, Krummel MF, van Zante A, Combes AJ, Angelo M, Fong L, Algazi AP, Ha P, Spitzer MH. PMID: 36931243; PMCID: PMC10348701.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    18. Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science. 2022 12 16; 378(6625):eaba1624. Allen GM, Frankel NW, Reddy NR, Bhargava HK, Yoshida MA, Stark SR, Purl M, Lee J, Yee JL, Yu W, Li AW, Garcia KC, El-Samad H, Roybal KT, Spitzer MH, Lim WA. PMID: 36520915; PMCID: PMC9970000.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    19. Innate type 2 immunity controls hair follicle commensalism by Demodex mites. Immunity. 2022 10 11; 55(10):1891-1908.e12. Ricardo-Gonzalez RR, Kotas ME, O'Leary CE, Singh K, Damsky W, Liao C, Arouge E, Tenvooren I, Marquez DM, Schroeder AW, Cohen JN, Fassett MS, Lee J, Daniel SG, Bittinger K, Díaz RE, Fraser JS, Ali N, Ansel KM, Spitzer MH, Liang HE, Locksley RM. PMID: 36044899; PMCID: PMC9561030.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients. Immunity. 2022 07 12; 55(7):1284-1298.e3. Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A, UCSF COMET Consortium, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ, Ansel KM, Spitzer MH. PMID: 35779527; PMCID: PMC9170540.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. A cytotoxic-skewed immune set point predicts low neutralizing antibody levels after Zika virus infection. Cell Rep. 2022 05 17; 39(7):110815. McCarthy EE, Odorizzi PM, Lutz E, Smullin CP, Tenvooren I, Stone M, Simmons G, Hunt PW, Feeney ME, Norris PJ, Busch MP, Spitzer MH, Rutishauser RL. PMID: 35584677; PMCID: PMC9151348.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    22. Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Cell. 2022 05 26; 185(11):1924-1942.e23. Reticker-Flynn NE, Zhang W, Belk JA, Basto PA, Escalante NK, Pilarowski GOW, Bejnood A, Martins MM, Kenkel JA, Linde IL, Bagchi S, Yuan R, Chang S, Spitzer MH, Carmi Y, Cheng J, Tolentino LL, Choi O, Wu N, Kong CS, Gentles AJ, Sunwoo JB, Satpathy AT, Plevritis SK, Engleman EG. PMID: 35525247; PMCID: PMC9149144.
      View in: PubMed   Mentions: 79     Fields:    Translation:Animals
    23. Postmitotic G1 phase survivin drives mitogen-independent cell division of B lymphocytes. Proc Natl Acad Sci U S A. 2022 05 03; 119(18):e2115567119. Singh A, Spitzer MH, Joy JP, Kaileh M, Qiu X, Nolan GP, Sen R. PMID: 35476510; PMCID: PMC9170024.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    24. Variation of Immune Cell Responses in Humans Reveals Sex-Specific Coordinated Signaling Across Cell Types. Front Immunol. 2022; 13:867016. Fragiadakis GK, Bjornson-Hooper ZB, Madhireddy D, Sachs K, Chen H, McIlwain DR, Spitzer MH, Bendall SC, Nolan GP. PMID: 35419006; PMCID: PMC8995898.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    25. Influence of Self-MHC Class I Recognition on the Dynamics of NK Cell Responses to Cytomegalovirus Infection. J Immunol. 2022 04 01; 208(7):1742-1754. Potempa M, Aguilar OA, Gonzalez-Hinojosa MDR, Tenvooren I, Marquez DM, Spitzer MH, Lanier LL. PMID: 35321880; PMCID: PMC8976824.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    26. A conserved immune trajectory of recovery in hospitalized COVID-19 patients. bioRxiv. 2022 Mar 16. Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Sandoval PM, UCSF COMET Consortium, Calfee CS, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Erle DJ, Ansel KM, Spitzer MH. PMID: 35313585; PMCID: PMC8936097.
      View in: PubMed   Mentions:
    27. A Comprehensive Atlas of Immunological Differences Between Humans, Mice, and Non-Human Primates. Front Immunol. 2022; 13:867015. Bjornson-Hooper ZB, Fragiadakis GK, Spitzer MH, Chen H, Madhireddy D, Hu K, Lundsten K, McIlwain DR, Nolan GP. PMID: 35359965; PMCID: PMC8962947.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    28. Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). Ishiyama K, Arakawa-Hoyt J, Aguilar OA, Damm I, Towfighi P, Sigdel T, Tamaki S, Babdor J, Spitzer MH, Reed EF, Sarwal MM, Lanier LL, CMV Systems Immunobiology Group. PMID: 35181606; PMCID: PMC8872722.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. Cellular architecture of human brain metastases. Cell. 2022 02 17; 185(4):729-745.e20. Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z. PMID: 35063085; PMCID: PMC8857062.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    30. Archetypes of checkpoint-responsive immunity. Trends Immunol. 2021 11; 42(11):960-974. Im K, Combes AJ, Spitzer MH, Satpathy AT, Krummel MF. PMID: 34642094; PMCID: PMC8724347.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    31. The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes. JCI Insight. 2021 09 22; 6(18). Dong S, Hiam-Galvez KJ, Mowery CT, Herold KC, Gitelman SE, Esensten JH, Liu W, Lares AP, Leinbach AS, Lee M, Nguyen V, Tamaki SJ, Tamaki W, Tamaki CM, Mehdizadeh M, Putnam AL, Spitzer MH, Ye CJ, Tang Q, Bluestone JA. PMID: 34324441; PMCID: PMC8492314.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCellsCTClinical Trials
    32. SCITO-seq: single-cell combinatorial indexed cytometry sequencing. Nat Methods. 2021 08; 18(8):903-911. Hwang B, Lee DS, Tamaki W, Sun Y, Ogorodnikov A, Hartoularos GC, Winters A, Yeung BZ, Nazor KL, Song YS, Chow ED, Spitzer MH, Ye CJ. PMID: 34354295; PMCID: PMC8643207.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    33. Pre-existing immune status associated with response to combination of sipuleucel-T and ipilimumab in patients with metastatic castration-resistant prostate cancer. J Immunother Cancer. 2021 05; 9(5). Sinha M, Zhang L, Subudhi S, Chen B, Marquez J, Liu EV, Allaire K, Cheung A, Ng S, Nguyen C, Friedlander TW, Aggarwal R, Spitzer M, Allison JP, Small EJ, Sharma P, Fong L. PMID: 33986125; PMCID: PMC8126308.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsCTClinical Trials
    34. Systemic immunity in cancer. Nat Rev Cancer. 2021 06; 21(6):345-359. Hiam-Galvez KJ, Allen BM, Spitzer MH. PMID: 33837297; PMCID: PMC8034277.
      View in: PubMed   Mentions: 421     Fields:    Translation:HumansAnimals
    35. Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response. Immunity. 2021 04 13; 54(4):829-844.e5. Levine LS, Hiam-Galvez KJ, Marquez DM, Tenvooren I, Madden MZ, Contreras DC, Dahunsi DO, Irish JM, Oluwole OO, Rathmell JC, Spitzer MH. PMID: 33705706; PMCID: PMC8046726.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    36. Landscape of coordinated immune responses to H1N1 challenge in humans. J Clin Invest. 2020 11 02; 130(11):5800-5816. Rahil Z, Leylek R, Schürch CM, Chen H, Bjornson-Hooper Z, Christensen SR, Gherardini PF, Bhate SS, Spitzer MH, Fragiadakis GK, Mukherjee N, Kim N, Jiang S, Yo J, Gaudilliere B, Affrime M, Bock B, Hensley SE, Idoyaga J, Aghaeepour N, Kim K, Nolan GP, McIlwain DR. PMID: 33044226; PMCID: PMC7598057.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsCTClinical Trials
    37. Functional CRISPR dissection of gene networks controlling human regulatory T cell identity. Nat Immunol. 2020 11; 21(11):1456-1466. Schumann K, Raju SS, Lauber M, Kolb S, Shifrut E, Cortez JT, Skartsis N, Nguyen VQ, Woo JM, Roth TL, Yu R, Nguyen MLT, Simeonov DR, Nguyen DN, Targ S, Gate RE, Tang Q, Bluestone JA, Spitzer MH, Ye CJ, Marson A. PMID: 32989329; PMCID: PMC7577958.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    38. ImmunoGlobe: enabling systems immunology with a manually curated intercellular immune interaction network. BMC Bioinformatics. 2020 Aug 10; 21(1):346. Atallah MB, Tandon V, Hiam KJ, Boyce H, Hori M, Atallah W, Spitzer MH, Engleman E, Mallick P. PMID: 32778050; PMCID: PMC7430879.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    39. Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer. Cell. 2020 06 25; 181(7):1612-1625.e13. Oh DY, Kwek SS, Raju SS, Li T, McCarthy E, Chow E, Aran D, Ilano A, Pai CS, Rancan C, Allaire K, Burra A, Sun Y, Spitzer MH, Mangul S, Porten S, Meng MV, Friedlander TW, Ye CJ, Fong L. PMID: 32497499; PMCID: PMC7321885.
      View in: PubMed   Mentions: 284     Fields:    Translation:HumansCells
    40. Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma. Ann Surg Oncol. 2020 Oct; 27(11):4122-4130. Levine LS, Mahuron KM, Tsai KK, Wu C, Mattis DM, Pauli ML, Oglesby A, Lee JC, Spitzer MH, Krummel MF, Algazi AP, Rosenblum MD, Alvarado M, Daud AI. PMID: 32488521; PMCID: PMC8317618.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Systemic dysfunction and plasticity of the immune macroenvironment in cancer models. Nat Med. 2020 07; 26(7):1125-1134. Allen BM, Hiam KJ, Burnett CE, Venida A, DeBarge R, Tenvooren I, Marquez DM, Cho NW, Carmi Y, Spitzer MH. PMID: 32451499; PMCID: PMC7384250.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimalsCells
    42. Depletion of microbiome-derived molecules in the host using Clostridium genetics. Science. 2019 12 13; 366(6471). Guo CJ, Allen BM, Hiam KJ, Dodd D, Van Treuren W, Higginbottom S, Nagashima K, Fischer CR, Sonnenburg JL, Spitzer MH, Fischbach MA. PMID: 31831639; PMCID: PMC7141153.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    43. Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nat Immunol. 2019 10; 20(10):1299-1310. Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST. PMID: 31534238.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    44. De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans. Nat Biotechnol. 2019 10; 37(10):1137-1144. Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S. PMID: 31427818.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    45. Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy. Cell Rep. 2019 07 16; 28(3):819-831.e4. Hartmann FJ, Babdor J, Gherardini PF, Amir ED, Jones K, Sahaf B, Marquez DM, Krutzik P, O'Donnell E, Sigal N, Maecker HT, Meyer E, Spitzer MH, Bendall SC. PMID: 31315057; PMCID: PMC6656694.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    46. Hacking the 'Cellular Immunology Agency': T cells caught in the act. Nat Immunol. 2019 04; 20(4):382-383. Spitzer MH. PMID: 30886420.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    47. Scalable Conjugation and Characterization of Immunoglobulins with Stable Mass Isotope Reporters for Single-Cell Mass Cytometry Analysis. Methods Mol Biol. 2019; 1989:55-81. Hartmann FJ, Simonds EF, Vivanco N, Bruce T, Borges L, Nolan GP, Spitzer MH, Bendall SC. PMID: 31077099; PMCID: PMC6687300.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    48. Autocrine TGFβ Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment. Cancer Immunol Res. 2019 02; 7(2):306-320. Gonzalez-Junca A, Driscoll KE, Pellicciotta I, Du S, Lo CH, Roy R, Parry R, Tenvooren I, Marquez DM, Spitzer MH, Barcellos-Hoff MH. PMID: 30538091; PMCID: PMC6828175.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    49. Metal-isotope-tagged monoclonal antibodies for high-dimensional mass cytometry. Nat Protoc. 2018 10; 13(10):2121-2148. Han G, Spitzer MH, Bendall SC, Fantl WJ, Nolan GP. PMID: 30258176; PMCID: PMC7075473.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    50. MetaCyto: A Tool for Automated Meta-analysis of Mass and Flow Cytometry Data. Cell Rep. 2018 07 31; 24(5):1377-1388. Hu Z, Jujjavarapu C, Hughey JJ, Andorf S, Lee HC, Gherardini PF, Spitzer MH, Thomas CG, Campbell J, Dunn P, Wiser J, Kidd BA, Dudley JT, Nolan GP, Bhattacharya S, Butte AJ. PMID: 30067990; PMCID: PMC6583920.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    51. Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System. Cell Rep. 2018 05 15; 23(7):2130-2141. Avanzi MP, Yeku O, Li X, Wijewarnasuriya DP, van Leeuwen DG, Cheung K, Park H, Purdon TJ, Daniyan AF, Spitzer MH, Brentjens RJ. PMID: 29768210; PMCID: PMC5986286.
      View in: PubMed   Mentions: 154     Fields:    Translation:HumansAnimalsCells
    52. Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis. Cell Stem Cell. 2018 02 01; 22(2):277. Kleppe M, Spitzer MH, Li S, Hill CE, Dong L, Papalexi E, De Groote S, Bowman RL, Keller M, Koppikar P, Rapaport FT, Teruya-Feldstein J, Gandara J, Mason CE, Nolan GP, Levine RL. PMID: 29395057; PMCID: PMC6260818.
      View in: PubMed   Mentions: 6     Fields:    
    53. A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. Nature. 2017 11 30; 551(7682):648-652. Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL. PMID: 29168502; PMCID: PMC5850949.
      View in: PubMed   Mentions: 486     Fields:    Translation:HumansAnimals
    54. Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis. Cell Stem Cell. 2017 10 05; 21(4):489-501.e7. Kleppe M, Spitzer MH, Li S, Hill CE, Dong L, Papalexi E, De Groote S, Bowman RL, Keller M, Koppikar P, Rapaport FT, Teruya-Feldstein J, Gandara J, Mason CE, Nolan GP, Levine RL. PMID: 28965767; PMCID: PMC5847260.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    55. Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017 07 25; 20(4):984-998. Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR. PMID: 28746881; PMCID: PMC5560086.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    56. Systemic Immunity Is Required for Effective Cancer Immunotherapy. Cell. 2017 01 26; 168(3):487-502.e15. Spitzer MH, Carmi Y, Reticker-Flynn NE, Kwek SS, Madhireddy D, Martins MM, Gherardini PF, Prestwood TR, Chabon J, Bendall SC, Fong L, Nolan GP, Engleman EG. PMID: 28111070; PMCID: PMC5312823.
      View in: PubMed   Mentions: 425     Fields:    Translation:HumansAnimalsCells
    57. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med. 2017 Feb; 23(2):174-184. Furman D, Chang J, Lartigue L, Bolen CR, Haddad F, Gaudilliere B, Ganio EA, Fragiadakis GK, Spitzer MH, Douchet I, Daburon S, Moreau JF, Nolan GP, Blanco P, Déchanet-Merville J, Dekker CL, Jojic V, Kuo CJ, Davis MM, Faustin B. PMID: 28092664; PMCID: PMC5320935.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimalsCells
    58. Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity. JCI Insight. 2016 11 03; 1(18):e89020. Carmi Y, Prestwood TR, Spitzer MH, Linde IL, Chabon J, Reticker-Flynn NE, Bhattacharya N, Zhang H, Zhang X, Basto PA, Burt BM, Alonso MN, Engleman EG. PMID: 27812544; PMCID: PMC5085602.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    59. Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy. J Immunol. 2016 12 01; 197(11):4482-4492. Fragiadakis GK, Baca QJ, Gherardini PF, Ganio EA, Gaudilliere DK, Tingle M, Lancero HL, McNeil LS, Spitzer MH, Wong RJ, Shaw GM, Darmstadt GL, Sylvester KG, Winn VD, Carvalho B, Lewis DB, Stevenson DK, Nolan GP, Aghaeepour N, Angst MS, Gaudilliere BL. PMID: 27793998; PMCID: PMC5125527.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    60. Automated mapping of phenotype space with single-cell data. Nat Methods. 2016 06; 13(6):493-6. Samusik N, Good Z, Spitzer MH, Davis KL, Nolan GP. PMID: 27183440; PMCID: PMC4896314.
      View in: PubMed   Mentions: 181     Fields:    Translation:AnimalsCells
    61. Mass Cytometry: Single Cells, Many Features. Cell. 2016 May 05; 165(4):780-91. Spitzer MH, Nolan GP. PMID: 27153492; PMCID: PMC4860251.
      View in: PubMed   Mentions: 490     Fields:    Translation:HumansAnimalsCells
    62. Metabolite profiles of rats in repeated dose toxicological studies after oral and inhalative exposure. Toxicol Lett. 2016 Jul 25; 255:11-23. Fabian E, Bordag N, Herold M, Kamp H, Krennrich G, Looser R, Ma-Hock L, Mellert W, Montoya G, Peter E, Prokudin A, Spitzer M, Strauss V, Walk T, Zbranek R, van Ravenzwaay B. PMID: 27153797.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsPHPublic Health
    63. IMMUNOLOGY. An interactive reference framework for modeling a dynamic immune system. Science. 2015 Jul 10; 349(6244):1259425. Spitzer MH, Gherardini PF, Fragiadakis GK, Bhattacharya N, Yuan RT, Hotson AN, Finck R, Carmi Y, Zunder ER, Fantl WJ, Bendall SC, Engleman EG, Nolan GP. PMID: 26160952; PMCID: PMC4537647.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimals
    64. Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity. Nature. 2015 May 07; 521(7550):99-104. Carmi Y, Spitzer MH, Linde IL, Burt BM, Prestwood TR, Perlman N, Davidson MG, Kenkel JA, Segal E, Pusapati GV, Bhattacharya N, Engleman EG. PMID: 25924063; PMCID: PMC4877172.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    65. Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm. Nat Protoc. 2015 Feb; 10(2):316-33. Zunder ER, Finck R, Behbehani GK, Amir el-AD, Krishnaswamy S, Gonzalez VD, Lorang CG, Bjornson Z, Spitzer MH, Bodenmiller B, Fantl WJ, Pe'er D, Nolan GP. PMID: 25612231; PMCID: PMC4347881.
      View in: PubMed   Mentions: 274     Fields:    
    66. Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16466-71. Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C. PMID: 25362052; PMCID: PMC4246343.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    67. Systems biology. Conditional density-based analysis of T cell signaling in single-cell data. Science. 2014 Nov 28; 346(6213):1250689. Krishnaswamy S, Spitzer MH, Mingueneau M, Bendall SC, Litvin O, Stone E, Pe'er D, Nolan GP. PMID: 25342659; PMCID: PMC4334155.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    68. A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis. J Neurosci. 2013 May 29; 33(22):9306-18. Megill A, Lee T, DiBattista AM, Song JM, Spitzer MH, Rubinshtein M, Habib LK, Capule CC, Mayer M, Turner RS, Kirkwood A, Yang J, Pak DT, Lee HK, Hoe HS. PMID: 23719799; PMCID: PMC3865503.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    69. The transcriptional landscape of αβ T cell differentiation. Nat Immunol. 2013 Jun; 14(6):619-32. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C, Immunological Genome Consortium, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Nageswara Rao T, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S. PMID: 23644507; PMCID: PMC3660436.
      View in: PubMed   Mentions: 157     Fields:    Translation:AnimalsCells
    70. Risks and benefits of testosterone therapy in older men. Nat Rev Endocrinol. 2013 Jul; 9(7):414-24. Spitzer M, Huang G, Basaria S, Travison TG, Bhasin S. PMID: 23591366.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    71. Thyrotoxicosis with post-treatment hypothyroidism in a patient with acute suppurative thyroiditis due to porphyromonas. Thyroid. 2012 Jan; 22(1):97-100. Spitzer M, Alexanian S, Farwell AP. PMID: 22136210.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    72. ApoE receptor 2 regulates synapse and dendritic spine formation. PLoS One. 2011 Feb 15; 6(2):e17203. Dumanis SB, Cha HJ, Song JM, Trotter JH, Spitzer M, Lee JY, Weeber EJ, Turner RS, Pak DT, Rebeck GW, Hoe HS. PMID: 21347244; PMCID: PMC3039666.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    73. Left lateralized P300 amplitude deficit in schizophrenic patients depends on pitch disparity. Biol Psychiatry. 1997 Mar 01; 41(5):541-9. Weisbrod M, Winkler S, Maier S, Hill H, Thomas C, Spitzer M. PMID: 9046986.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    74. [Significance of historical and current hallucinogenic research in psychiatry]. Nervenarzt. 1993 Sep; 64(9):562-71. Hermle L, Gouzoulis E, Oepen G, Spitzer M, Kovar KA, Borchardt D, Fünfgeld M, Berger M. PMID: 8413757.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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