 Matthew Spitzer, PhD
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| Title | Assistant Researcher |
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| School | UCSF School of Medicine |
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| Department | Microbiology and Immunology |
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| Address | 513 Parnassus Ave
San Francisco CA 94143
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| vCard | Download vCard |
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 Biography | Stanford University | PhD | | Immunology | | Georgetown University | BS | | Biology |
Overview The Spitzer Lab is working to develop our understanding of how the immune system coordinates its responses across the organism with an emphasis on tumor immunology. We combine methods in experimental immunology and cancer biology with computation to understand the modes in which the immune system can respond to tumors and to rationally initiate curative immune responses against cancer.
ORNG Applications Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Dodd D, Spitzer M, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL. A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. Nature. 2017 11 30; 551(7682):648-652. PMID: 29168502.
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Kleppe M, Spitzer M, Li S, Hill CE, Dong L, Papalexi E, De Groote S, Bowman RL, Keller M, Koppikar P, Rapaport FT, Teruya-Feldstein J, Gandara J, Mason CE, Nolan GP, Levine RL. Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis. Cell Stem Cell. 2017 Oct 05; 21(4):489-501.e7. PMID: 28965767.
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Spitzer M, Carmi Y, Reticker-Flynn NE, Kwek SS, Madhireddy D, Martins MM, Gherardini PF, Prestwood TR, Chabon J, Bendall SC, Fong L, Nolan GP, Engleman EG. Systemic Immunity Is Required for Effective Cancer Immunotherapy. Cell. 2017 Jan 26; 168(3):487-502.e15. PMID: 28111070.
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Furman D, Chang J, Lartigue L, Bolen CR, Haddad F, Gaudilliere B, Ganio EA, Fragiadakis GK, Spitzer M, Douchet I, Daburon S, Moreau JF, Nolan GP, Blanco P, Déchanet-Merville J, Dekker CL, Jojic V, Kuo CJ, Davis MM, Faustin B. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med. 2017 Feb; 23(2):174-184. PMID: 28092664.
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Carmi Y, Prestwood TR, Spitzer M, Linde IL, Chabon J, Reticker-Flynn NE, Bhattacharya N, Zhang H, Zhang X, Basto PA, Burt BM, Alonso MN, Engleman EG. Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity. JCI Insight. 2016 Nov 03; 1(18):e89020. PMID: 27812544.
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Samusik N, Good Z, Spitzer M, Davis KL, Nolan GP. Automated mapping of phenotype space with single-cell data. Nat Methods. 2016 06; 13(6):493-6. PMID: 27183440; PMCID: PMC4896314 [Available on 11/16/16].
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Spitzer M, Nolan GP. Mass Cytometry: Single Cells, Many Features. Cell. 2016 May 05; 165(4):780-91. PMID: 27153492; PMCID: PMC4860251 [Available on 05/05/17].
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Spitzer M, Gherardini PF, Fragiadakis GK, Bhattacharya N, Yuan RT, Hotson AN, Finck R, Carmi Y, Zunder ER, Fantl WJ, Bendall SC, Engleman EG, Nolan GP. IMMUNOLOGY. An interactive reference framework for modeling a dynamic immune system. Science. 2015 Jul 10; 349(6244):1259425. PMID: 26160952; PMCID: PMC4537647.
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Carmi Y, Spitzer M, Linde IL, Burt BM, Prestwood TR, Perlman N, Davidson MG, Kenkel JA, Segal E, Pusapati GV, Bhattacharya N, Engleman EG. Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity. Nature. 2015 May 07; 521(7550):99-104. PMID: 25924063; PMCID: PMC4877172.
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Zunder ER, Finck R, Behbehani GK, Amir el-AD, Krishnaswamy S, Gonzalez VD, Lorang CG, Bjornson Z, Spitzer M, Bodenmiller B, Fantl WJ, Pe'er D, Nolan GP. Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm. Nat Protoc. 2015 Feb; 10(2):316-33. PMID: 25612231; PMCID: PMC4347881.
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Mingueneau M, Krishnaswamy S, Spitzer M, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C. Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16466-71. PMID: 25362052; PMCID: PMC4246343.
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Krishnaswamy S, Spitzer M, Mingueneau M, Bendall SC, Litvin O, Stone E, Pe'er D, Nolan GP. Systems biology. Conditional density-based analysis of T cell signaling in single-cell data. Science. 2014 Nov 28; 346(6213):1250689. PMID: 25342659; PMCID: PMC4334155.
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Megill A, Lee T, DiBattista AM, Song JM, Spitzer M, Rubinshtein M, Habib LK, Capule CC, Mayer M, Turner RS, Kirkwood A, Yang J, Pak DT, Lee HK, Hoe HS. A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis. J Neurosci. 2013 May 29; 33(22):9306-18. PMID: 23719799; PMCID: PMC3865503.
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Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer M, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C. The transcriptional landscape of aß T cell differentiation. Nat Immunol. 2013 Jun; 14(6):619-32. PMID: 23644507; PMCID: PMC3660436.
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Dumanis SB, Cha HJ, Song JM, Trotter JH, Spitzer M, Lee JY, Weeber EJ, Turner RS, Pak DT, Rebeck GW, Hoe HS. ApoE receptor 2 regulates synapse and dendritic spine formation. PLoS One. 2011 Feb 15; 6(2):e17203. PMID: 21347244; PMCID: PMC3039666.
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