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Matthew Spitzer, PhD

TitleAssistant Researcher
SchoolUCSF School of Medicine
DepartmentMicrobiology and Immunology
Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Biography 
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    Stanford UniversityPhDImmunology
    Georgetown UniversityBSBiology

    Collapse Overview 
    Collapse Overview
    The Spitzer Lab is working to develop our understanding of how the immune system coordinates its responses across the organism with an emphasis on tumor immunology. We combine methods in experimental immunology and cancer biology with computation to understand the modes in which the immune system can respond to tumors and to rationally initiate curative immune responses against cancer.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer M, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR. Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017 Jul 25; 20(4):984-998. PMID: 28746881.
      View in: PubMed
    2. Furman D, Chang J, Lartigue L, Bolen CR, Haddad F, Gaudilliere B, Ganio EA, Fragiadakis GK, Spitzer M, Douchet I, Daburon S, Moreau JF, Nolan GP, Blanco P, Déchanet-Merville J, Dekker CL, Jojic V, Kuo CJ, Davis MM, Faustin B. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med. 2017 Jan 16. PMID: 28092664.
      View in: PubMed
    3. Spitzer M, Carmi Y, Reticker-Flynn NE, Kwek SS, Madhireddy D, Martins MM, Gherardini PF, Prestwood TR, Chabon J, Bendall SC, Fong L, Nolan GP, Engleman EG. Systemic Immunity Is Required for Effective Cancer Immunotherapy. Cell. 2017 Jan 10. PMID: 28111070.
      View in: PubMed
    4. Carmi Y, Prestwood TR, Spitzer M, Linde IL, Chabon J, Reticker-Flynn NE, Bhattacharya N, Zhang H, Zhang X, Basto PA, Burt BM, Alonso MN, Engleman EG. Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity. JCI Insight. 2016 Nov 3; 1(18):e89020. PMID: 27812544.
      View in: PubMed
    5. Fragiadakis GK, Baca QJ, Gherardini PF, Ganio EA, Gaudilliere DK, Tingle M, Lancero HL, McNeil LS, Spitzer M, Wong RJ, Shaw GM, Darmstadt GL, Sylvester KG, Winn VD, Carvalho B, Lewis DB, Stevenson DK, Nolan GP, Aghaeepour N, Angst MS, Gaudilliere BL. Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy. J Immunol. 2016 Dec 1; 197(11):4482-4492. PMID: 27793998.
      View in: PubMed
    6. Samusik N, Good Z, Spitzer M, Davis KL, Nolan GP. Automated mapping of phenotype space with single-cell data. Nat Methods. 2016 Jun; 13(6):493-6. PMID: 27183440; PMCID: PMC4896314 [Available on 11/16/16].
      View in: PubMed, PubMed Central
    7. Spitzer M, Nolan GP. Mass Cytometry: Single Cells, Many Features. Cell. 2016 May 5; 165(4):780-91. PMID: 27153492; PMCID: PMC4860251 [Available on 05/05/17].
      View in: PubMed, PubMed Central
    8. Spitzer M, Gherardini PF, Fragiadakis GK, Bhattacharya N, Yuan RT, Hotson AN, Finck R, Carmi Y, Zunder ER, Fantl WJ, Bendall SC, Engleman EG, Nolan GP. IMMUNOLOGY. An interactive reference framework for modeling a dynamic immune system. Science. 2015 Jul 10; 349(6244):1259425. PMID: 26160952; PMCID: PMC4537647.
      View in: PubMed, PubMed Central
    9. Carmi Y, Spitzer M, Linde IL, Burt BM, Prestwood TR, Perlman N, Davidson MG, Kenkel JA, Segal E, Pusapati GV, Bhattacharya N, Engleman EG. Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity. Nature. 2015 May 7; 521(7550):99-104. PMID: 25924063; PMCID: PMC4877172.
      View in: PubMed, PubMed Central
    10. Zunder ER, Finck R, Behbehani GK, Amir el-AD, Krishnaswamy S, Gonzalez VD, Lorang CG, Bjornson Z, Spitzer M, Bodenmiller B, Fantl WJ, Pe'er D, Nolan GP. Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm. Nat Protoc. 2015 Feb; 10(2):316-33. PMID: 25612231; PMCID: PMC4347881.
      View in: PubMed, PubMed Central
    11. Mingueneau M, Krishnaswamy S, Spitzer M, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C. Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16466-71. PMID: 25362052; PMCID: PMC4246343.
      View in: PubMed, PubMed Central
    12. Krishnaswamy S, Spitzer M, Mingueneau M, Bendall SC, Litvin O, Stone E, Pe'er D, Nolan GP. Systems biology. Conditional density-based analysis of T cell signaling in single-cell data. Science. 2014 Nov 28; 346(6213):1250689. PMID: 25342659; PMCID: PMC4334155.
      View in: PubMed, PubMed Central
    13. Megill A, Lee T, DiBattista AM, Song JM, Spitzer M, Rubinshtein M, Habib LK, Capule CC, Mayer M, Turner RS, Kirkwood A, Yang J, Pak DT, Lee HK, Hoe HS. A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis. J Neurosci. 2013 May 29; 33(22):9306-18. PMID: 23719799; PMCID: PMC3865503.
      View in: PubMed, PubMed Central
    14. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer M, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C. The transcriptional landscape of aß T cell differentiation. Nat Immunol. 2013 Jun; 14(6):619-32. PMID: 23644507; PMCID: PMC3660436.
      View in: PubMed, PubMed Central
    15. Spitzer M, Huang G, Basaria S, Travison TG, Bhasin S. Risks and benefits of testosterone therapy in older men. Nat Rev Endocrinol. 2013 Jul; 9(7):414-24. PMID: 23591366.
      View in: PubMed
    16. Dumanis SB, Cha HJ, Song JM, Trotter JH, Spitzer M, Lee JY, Weeber EJ, Turner RS, Pak DT, Rebeck GW, Hoe HS. ApoE receptor 2 regulates synapse and dendritic spine formation. PLoS One. 2011; 6(2):e17203. PMID: 21347244; PMCID: PMC3039666.
      View in: PubMed, PubMed Central
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