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Matthew Spitzer, PhD

Title(s)Assistant Professor, Otolaryngology
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
ORCID ORCID Icon0000-0002-5291-3819 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Stanford UniversityPhDImmunology
    Georgetown UniversityBSBiology

    Collapse Overview 
    Collapse Overview
    The Spitzer Lab is working to develop our understanding of how the immune system coordinates its responses across the organism with an emphasis on tumor immunology. We combine methods in experimental immunology and cancer biology with computation to understand the modes in which the immune system can respond to tumors and to rationally initiate curative immune responses against cancer.

    Collapse Research 
    Collapse Research Activities and Funding
    Single-cell High-dimensional Characterization of the Bone Marrow Microenvironment in Health and Disease
    NIH R21AG057224Jul 15, 2017 - May 31, 2019
    Role: Co-Principal Investigator
    Quantitatively modeling immune responses to cancer
    NIH DP5OD023056Sep 21, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Revealing the tumor-immune network by mass cytometry
    NIH F31CA189331Sep 30, 2014 - Sep 29, 2018
    Role: Principal Investigator

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Systemic immunity in cancer. Nat Rev Cancer. 2021 Apr 09. PMID: 33837297.
      View in: PubMed   Mentions:    Fields:    
    2. Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response. Immunity. 2021 Mar 06. PMID: 33705706.
      View in: PubMed   Mentions:    Fields:    
    3. Landscape of coordinated immune responses to H1N1 challenge in humans. J Clin Invest. 2020 Nov 02; 130(11):5800-5816. Rahil Z, Leylek R, Schürch CM, Chen H, Bjornson-Hooper Z, Christensen SR, Gherardini PF, Bhate SS, Spitzer MH, Fragiadakis GK, Mukherjee N, Kim N, Jiang S, Yo J, Gaudilliere B, Affrime M, Bock B, Hensley SE, Idoyaga J, Aghaeepour N, Kim K, Nolan GP, McIlwain DR. PMID: 33044226.
      View in: PubMed   Mentions:    Fields:    
    4. Functional CRISPR dissection of gene networks controlling human regulatory T cell identity. Nat Immunol. 2020 11; 21(11):1456-1466. Schumann K, Raju SS, Lauber M, Kolb S, Shifrut E, Cortez JT, Skartsis N, Nguyen VQ, Woo JM, Roth TL, Yu R, Nguyen MLT, Simeonov DR, Nguyen DN, Targ S, Gate RE, Tang Q, Bluestone JA, Spitzer MH, Ye CJ, Marson A. PMID: 32989329.
      View in: PubMed   Mentions: 1     Fields:    
    5. ImmunoGlobe: enabling systems immunology with a manually curated intercellular immune interaction network. BMC Bioinformatics. 2020 Aug 10; 21(1):346. Atallah MB, Tandon V, Hiam KJ, Boyce H, Hori M, Atallah W, Spitzer MH, Engleman E, Mallick P. PMID: 32778050.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer. Cell. 2020 06 25; 181(7):1612-1625.e13. Oh DY, Kwek SS, Raju SS, Li T, McCarthy E, Chow E, Aran D, Ilano A, Pai CS, Rancan C, Allaire K, Burra A, Sun Y, Spitzer MH, Mangul S, Porten S, Meng MV, Friedlander TW, Ye CJ, Fong L. PMID: 32497499.
      View in: PubMed   Mentions: 7     Fields:    
    7. Tumor Immune Profiling-Based Neoadjuvant Immunotherapy for Locally Advanced Melanoma. Ann Surg Oncol. 2020 Oct; 27(11):4122-4130. Levine LS, Mahuron KM, Tsai KK, Wu C, Mattis DM, Pauli ML, Oglesby A, Lee JC, Spitzer MH, Krummel MF, Algazi AP, Rosenblum MD, Alvarado M, Daud AI. PMID: 32488521.
      View in: PubMed   Mentions:    Fields:    
    8. Systemic dysfunction and plasticity of the immune macroenvironment in cancer models. Nat Med. 2020 07; 26(7):1125-1134. Allen BM, Hiam KJ, Burnett CE, Venida A, DeBarge R, Tenvooren I, Marquez DM, Cho NW, Carmi Y, Spitzer MH. PMID: 32451499.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    9. Depletion of microbiome-derived molecules in the host using Clostridium genetics. Science. 2019 12 13; 366(6471). Guo CJ, Allen BM, Hiam KJ, Dodd D, Van Treuren W, Higginbottom S, Nagashima K, Fischer CR, Sonnenburg JL, Spitzer MH, Fischbach MA. PMID: 31831639.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity. Nat Immunol. 2019 10; 20(10):1299-1310. Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST. PMID: 31534238.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans. Nat Biotechnol. 2019 10; 37(10):1137-1144. Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S. PMID: 31427818.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy. Cell Rep. 2019 07 16; 28(3):819-831.e4. Hartmann FJ, Babdor J, Gherardini PF, Amir ED, Jones K, Sahaf B, Marquez DM, Krutzik P, O'Donnell E, Sigal N, Maecker HT, Meyer E, Spitzer MH, Bendall SC. PMID: 31315057.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    13. Hacking the 'Cellular Immunology Agency': T cells caught in the act. Nat Immunol. 2019 04; 20(4):382-383. Spitzer MH. PMID: 30886420.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Scalable Conjugation and Characterization of Immunoglobulins with Stable Mass Isotope Reporters for Single-Cell Mass Cytometry Analysis. Methods Mol Biol. 2019; 1989:55-81. Hartmann FJ, Simonds EF, Vivanco N, Bruce T, Borges L, Nolan GP, Spitzer MH, Bendall SC. PMID: 31077099.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Autocrine TGFß Is a Survival Factor for Monocytes and Drives Immunosuppressive Lineage Commitment. Cancer Immunol Res. 2019 02; 7(2):306-320. Gonzalez-Junca A, Driscoll KE, Pellicciotta I, Du S, Lo CH, Roy R, Parry R, Tenvooren I, Marquez DM, Spitzer MH, Barcellos-Hoff MH. PMID: 30538091.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    16. Metal-isotope-tagged monoclonal antibodies for high-dimensional mass cytometry. Nat Protoc. 2018 10; 13(10):2121-2148. Han G, Spitzer MH, Bendall SC, Fantl WJ, Nolan GP. PMID: 30258176.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    17. MetaCyto: A Tool for Automated Meta-analysis of Mass and Flow Cytometry Data. Cell Rep. 2018 07 31; 24(5):1377-1388. Hu Z, Jujjavarapu C, Hughey JJ, Andorf S, Lee HC, Gherardini PF, Spitzer MH, Thomas CG, Campbell J, Dunn P, Wiser J, Kidd BA, Dudley JT, Nolan GP, Bhattacharya S, Butte AJ. PMID: 30067990.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System. Cell Rep. 2018 05 15; 23(7):2130-2141. Avanzi MP, Yeku O, Li X, Wijewarnasuriya DP, van Leeuwen DG, Cheung K, Park H, Purdon TJ, Daniyan AF, Spitzer MH, Brentjens RJ. PMID: 29768210.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    19. Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis. Cell Stem Cell. 2018 02 01; 22(2):277. Kleppe M, Spitzer MH, Li S, Hill CE, Dong L, Papalexi E, De Groote S, Bowman RL, Keller M, Koppikar P, Rapaport FT, Teruya-Feldstein J, Gandara J, Mason CE, Nolan GP, Levine RL. PMID: 29395057.
      View in: PubMed   Mentions: 3     Fields:    
    20. A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites. Nature. 2017 11 30; 551(7682):648-652. Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL. PMID: 29168502.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimals
    21. Jak1 Integrates Cytokine Sensing to Regulate Hematopoietic Stem Cell Function and Stress Hematopoiesis. Cell Stem Cell. 2017 10 05; 21(4):489-501.e7. Kleppe M, Spitzer MH, Li S, Hill CE, Dong L, Papalexi E, De Groote S, Bowman RL, Keller M, Koppikar P, Rapaport FT, Teruya-Feldstein J, Gandara J, Mason CE, Nolan GP, Levine RL. PMID: 28965767.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells. Cell Rep. 2017 07 25; 20(4):984-998. Cavrois M, Banerjee T, Mukherjee G, Raman N, Hussien R, Rodriguez BA, Vasquez J, Spitzer MH, Lazarus NH, Jones JJ, Ochsenbauer C, McCune JM, Butcher EC, Arvin AM, Sen N, Greene WC, Roan NR. PMID: 28746881.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    23. Systemic Immunity Is Required for Effective Cancer Immunotherapy. Cell. 2017 01 26; 168(3):487-502.e15. Spitzer MH, Carmi Y, Reticker-Flynn NE, Kwek SS, Madhireddy D, Martins MM, Gherardini PF, Prestwood TR, Chabon J, Bendall SC, Fong L, Nolan GP, Engleman EG. PMID: 28111070.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansAnimalsCells
    24. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states. Nat Med. 2017 Feb; 23(2):174-184. Furman D, Chang J, Lartigue L, Bolen CR, Haddad F, Gaudilliere B, Ganio EA, Fragiadakis GK, Spitzer MH, Douchet I, Daburon S, Moreau JF, Nolan GP, Blanco P, Déchanet-Merville J, Dekker CL, Jojic V, Kuo CJ, Davis MM, Faustin B. PMID: 28092664.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    25. Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity. JCI Insight. 2016 11 03; 1(18):e89020. Carmi Y, Prestwood TR, Spitzer MH, Linde IL, Chabon J, Reticker-Flynn NE, Bhattacharya N, Zhang H, Zhang X, Basto PA, Burt BM, Alonso MN, Engleman EG. PMID: 27812544.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    26. Mapping the Fetomaternal Peripheral Immune System at Term Pregnancy. J Immunol. 2016 12 01; 197(11):4482-4492. Fragiadakis GK, Baca QJ, Gherardini PF, Ganio EA, Gaudilliere DK, Tingle M, Lancero HL, McNeil LS, Spitzer MH, Wong RJ, Shaw GM, Darmstadt GL, Sylvester KG, Winn VD, Carvalho B, Lewis DB, Stevenson DK, Nolan GP, Aghaeepour N, Angst MS, Gaudilliere BL. PMID: 27793998.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    27. Automated mapping of phenotype space with single-cell data. Nat Methods. 2016 06; 13(6):493-6. Samusik N, Good Z, Spitzer MH, Davis KL, Nolan GP. PMID: 27183440.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    28. Mass Cytometry: Single Cells, Many Features. Cell. 2016 May 05; 165(4):780-91. Spitzer MH, Nolan GP. PMID: 27153492.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansAnimalsCells
    29. IMMUNOLOGY. An interactive reference framework for modeling a dynamic immune system. Science. 2015 Jul 10; 349(6244):1259425. Spitzer MH, Gherardini PF, Fragiadakis GK, Bhattacharya N, Yuan RT, Hotson AN, Finck R, Carmi Y, Zunder ER, Fantl WJ, Bendall SC, Engleman EG, Nolan GP. PMID: 26160952.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimals
    30. Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity. Nature. 2015 May 07; 521(7550):99-104. Carmi Y, Spitzer MH, Linde IL, Burt BM, Prestwood TR, Perlman N, Davidson MG, Kenkel JA, Segal E, Pusapati GV, Bhattacharya N, Engleman EG. PMID: 25924063.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    31. Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm. Nat Protoc. 2015 Feb; 10(2):316-33. Zunder ER, Finck R, Behbehani GK, Amir el-AD, Krishnaswamy S, Gonzalez VD, Lorang CG, Bjornson Z, Spitzer MH, Bodenmiller B, Fantl WJ, Pe'er D, Nolan GP. PMID: 25612231.
      View in: PubMed   Mentions: 107     Fields:    
    32. Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16466-71. Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C. PMID: 25362052.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    33. Systems biology. Conditional density-based analysis of T cell signaling in single-cell data. Science. 2014 Nov 28; 346(6213):1250689. Krishnaswamy S, Spitzer MH, Mingueneau M, Bendall SC, Litvin O, Stone E, Pe'er D, Nolan GP. PMID: 25342659.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    34. A tetra(ethylene glycol) derivative of benzothiazole aniline enhances Ras-mediated spinogenesis. J Neurosci. 2013 May 29; 33(22):9306-18. Megill A, Lee T, DiBattista AM, Song JM, Spitzer MH, Rubinshtein M, Habib LK, Capule CC, Mayer M, Turner RS, Kirkwood A, Yang J, Pak DT, Lee HK, Hoe HS. PMID: 23719799.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    35. The transcriptional landscape of aß T cell differentiation. Nat Immunol. 2013 Jun; 14(6):619-32. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C, , Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Nageswara Rao T, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S. PMID: 23644507.
      View in: PubMed   Mentions: 89     Fields:    Translation:AnimalsCells
    36. Risks and benefits of testosterone therapy in older men. Nat Rev Endocrinol. 2013 Jul; 9(7):414-24. Spitzer M, Huang G, Basaria S, Travison TG, Bhasin S. PMID: 23591366.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    37. Thyrotoxicosis with post-treatment hypothyroidism in a patient with acute suppurative thyroiditis due to porphyromonas. Thyroid. 2012 Jan; 22(1):97-100. Spitzer M, Alexanian S, Farwell AP. PMID: 22136210.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    38. ApoE receptor 2 regulates synapse and dendritic spine formation. PLoS One. 2011 Feb 15; 6(2):e17203. Dumanis SB, Cha HJ, Song JM, Trotter JH, Spitzer M, Lee JY, Weeber EJ, Turner RS, Pak DT, Rebeck GW, Hoe HS. PMID: 21347244.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    39. Left lateralized P300 amplitude deficit in schizophrenic patients depends on pitch disparity. Biol Psychiatry. 1997 Mar 01; 41(5):541-9. Weisbrod M, Winkler S, Maier S, Hill H, Thomas C, Spitzer M. PMID: 9046986.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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