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Considerations for Cell and Gene Therapy Programs Entering the Clinical Space. Clin Pharmacol Ther. 2023 09; 114(3):569-577.
Walford GA, Bautmans A, Cannon C, Duncan KE, Deschamps K, Matthews RP, Nussbaum J, Stoch SA. PMID: 37309988.
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Humans
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Population pharmacokinetic analysis of the P2X3-receptor antagonist gefapixant. CPT Pharmacometrics Syst Pharmacol. 2023 May 05.
Chawla A, Largajolli A, Hussain A, Kleijn H, Ait-Oudhia S, Anton J, Krishna Ananthula H, Nussbaum J, La Rosa C, Gheyas F. PMID: 37147897.
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1 Fields:
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Transition of care in inborn errors of immunity: Outcomes of a single-center quality improvement initiative. J Allergy Clin Immunol Pract. 2023 Jul; 11(7):2245-2247.e1.
Sanchez LA, Tang M, Ahmed A, Nussbaum JC, Nguyen DN, Muskat M, Chen XH, Pham MN. PMID: 37119980.
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Humans
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International consortium for innovation and quality: An industry perspective on the nonclinical and early clinical development of intravitreal drugs. Clin Transl Sci. 2023 05; 16(5):723-741.
Pruimboom-Brees IM, Gupta S, Chemuturi N, Booler HS, Nimz E, Ferrell Ramos M, Caruso A, Maass KF, Bantseev V, Huang Q, Choules MP, Nussbaum JC, Kanodia J, Thompson C, Durairaj C. PMID: 36651217; PMCID: PMC10175998.
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1 Fields:
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Humans
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Effects of Renal Impairment on the Pharmacokinetics of Gefapixant, a P2X3 Receptor Antagonist. J Clin Pharmacol. 2022 11; 62(11):1435-1444.
Nussbaum JC, Hussain A, Min KC, Marbury TC, Lasseter K, Stoch SA, Iwamoto M. PMID: 35656754.
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1 Fields:
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Humans
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A Randomized, Placebo-Controlled Study to Investigate the Safety, Tolerability, and Pharmacokinetics of 3 Weeks of Orally Administered Gefapixant in Healthy Younger and Older Adults. Lung. 2022 06; 200(3):315-323.
Nussbaum J, Hussain A, Ford A, Butera P, Kitt M, Smith S, Stoch A, Iwamoto M. PMID: 35670873.
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1 Fields:
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Clinical Formulation Bridging of Gefapixant, a P2X3-Receptor Antagonist, for the Treatment of Chronic Cough. Clin Pharmacol Drug Dev. 2022 Sep; 11(9):1054-1067.
Gupta P, Hussain A, Ford AP, Smith S, Nussbaum JC, Stoch A, Iwamoto M. PMID: 35510785; PMCID: PMC9540877.
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Characterization of the absorption, metabolism, excretion, and mass balance of gefapixant in humans. Pharmacol Res Perspect. 2022 02; 10(1):e00924.
Nussbaum JC, Hussain A, Ma B, Min KC, Chen Q, Tomek C, Iwamoto M, Stoch SA. PMID: 35106949; PMCID: PMC8929362.
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4 Fields:
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Humans
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Assessment of the Effect of Pyrimethamine, a Potent Inhibitor of Multidrug and Toxin Extrusion Protein 1/2K, on the Pharmacokinetics of Gefapixant (MK-7264), a P2X3 Receptor Antagonist. Clin Pharmacol Drug Dev. 2022 01; 11(1):123-128.
Nussbaum JC, Hussain A, Ma B, Min KC, Evers R, Li Y, Garrett G, Stoch SA, Iwamoto M. PMID: 34145987.
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3 Fields:
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Humans
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Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming. Immunity. 2019 06 18; 50(6):1425-1438.e5.
Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM. PMID: 31128962; PMCID: PMC6645687.
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108 Fields:
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Tissue signals imprint ILC2 identity with anticipatory function. Nat Immunol. 2018 10; 19(10):1093-1099.
Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM. PMID: 30201992; PMCID: PMC6202223.
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203 Fields:
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1021 Origin of type 2 innate lymphoid cells in the skin. Journal of Investigative Dermatology. 2018 May 1; 138(5):s173.
Lee LJ, Schneider SC, Liang LH, Ricardo-Gonzalez RR, Nussbaum NJ, Smith SL, Villeda VS, Locksley LR. .
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Isolation and Identification of Group 2 Innate Lymphoid Cells in Settings of Type 2 Inflammation. Methods Mol Biol. 2018; 1799:93-107.
Nussbaum JC, Ortiz-Carpena JF. PMID: 29956147.
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LB973 Characterization of tissue-resident ILC2 heterogeneity in homeostasis. Journal of Investigative Dermatology. 2017 Oct 1; 137(10):b8.
Ricardo-Gonzalez RR, Van Dyken VS, Molofsky MA, Nussbaum NJ, Lee LJ, Locksley LR. .
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A tissue checkpoint regulates type 2 immunity. Nat Immunol. 2016 Dec; 17(12):1381-1387.
Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM. PMID: 27749840; PMCID: PMC5275767.
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121 Fields:
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A Case of Hypercalcemia and Overexpression of CYP27B1 in Skeletal Muscle Lesions in a Patient with HIV Infection After Cosmetic Injections with Polymethylmethacrylate (PMMA) for Wasting. Calcif Tissue Int. 2015 Dec; 97(6):634-9.
Hindi SM, Wang Y, Jones KD, Nussbaum JC, Chang Y, Masharani U, Bikle D, Shoback DM, Hsiao EC. PMID: 26253396; PMCID: PMC4861400.
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8 Fields:
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Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis. Mucosal Immunol. 2016 Jan; 9(1):275-86.
Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM. PMID: 26129648; PMCID: PMC4698110.
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101 Fields:
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Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 2015 Jul 21; 43(1):161-74.
Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. PMID: 26092469; PMCID: PMC4512852.
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230 Fields:
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Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell. 2015 Jan 15; 160(1-2):74-87.
Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A. PMID: 25543153; PMCID: PMC4297518.
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341 Fields:
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Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells. Immunity. 2014 Mar 20; 40(3):414-24.
Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM. PMID: 24631157; PMCID: PMC4019510.
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121 Fields:
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Determinants of mortality in a combined cohort of 501 patients with HIV-associated Cryptococcal meningitis: implications for improving outcomes. Clin Infect Dis. 2014 Mar; 58(5):736-45.
Jarvis JN, Bicanic T, Loyse A, Namarika D, Jackson A, Nussbaum JC, Longley N, Muzoora C, Phulusa J, Taseera K, Kanyembe C, Wilson D, Hosseinipour MC, Brouwer AE, Limmathurotsakul D, White N, van der Horst C, Wood R, Meintjes G, Bradley J, Jaffar S, Harrison T. PMID: 24319084; PMCID: PMC3922213.
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181 Fields:
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Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8.
Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. PMID: 24037376; PMCID: PMC3795960.
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504 Fields:
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265 Cooperative activation of innate lymphoid type 2 cells (ILC2) by epithelial cytokines in response to chitin. Cytokine. 2013 Sep 1; 63(3):306.
Van Dyken VS, Mohapatra MA, Nussbaum NJ, Liang LH, Locksley LR. .
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Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. J Leukoc Biol. 2013 Nov; 94(5):877-84.
Bando JK, Nussbaum JC, Liang HE, Locksley RM. PMID: 23924659; PMCID: PMC3800063.
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53 Fields:
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434 Fields:
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A phase II randomized controlled trial adding oral flucytosine to high-dose fluconazole, with short-course amphotericin B, for cryptococcal meningitis. AIDS. 2012 Jul 17; 26(11):1363-70.
Jackson AT, Nussbaum JC, Phulusa J, Namarika D, Chikasema M, Kanyemba C, Jarvis JN, Jaffar S, Hosseinipour MC, van der Horst C, Harrison TS. PMID: 22526517; PMCID: PMC3776948.
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51 Fields:
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HumansCTClinical Trials
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Infectious (Non)tolerance--frustrated commensalism gone awry? Cold Spring Harb Perspect Biol. 2012 May 01; 4(5).
Nussbaum JC, Locksley RM. PMID: 22456498; PMCID: PMC3331693.
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9 Fields:
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Combination flucytosine and high-dose fluconazole compared with fluconazole monotherapy for the treatment of cryptococcal meningitis: a randomized trial in Malawi. Clin Infect Dis. 2010 Feb 01; 50(3):338-44.
Nussbaum JC, Jackson A, Namarika D, Phulusa J, Kenala J, Kanyemba C, Jarvis JN, Jaffar S, Hosseinipour MC, Kamwendo D, van der Horst CM, Harrison TS. PMID: 20038244; PMCID: PMC2805957.
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90 Fields:
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Cryptococcus neoformans virulence gene discovery through insertional mutagenesis. Eukaryot Cell. 2004 Apr; 3(2):420-9.
Idnurm A, Reedy JL, Nussbaum JC, Heitman J. PMID: 15075272; PMCID: PMC387659.
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94 Fields:
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Enzymes that counteract nitrosative stress promote fungal virulence. Curr Biol. 2003 Nov 11; 13(22):1963-8.
de Jesús-Berríos M, Liu L, Nussbaum JC, Cox GM, Stamler JS, Heitman J. PMID: 14614821.
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80 Fields:
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2006 expressed-sequence tags derived from human chromosome 7-enriched cDNA libraries. Genome Res. 1997 Mar; 7(3):281-92.
Touchman JW, Bouffard GG, Weintraub LA, Idol JR, Wang L, Robbins CM, Nussbaum JC, Lovett M, Green ED. PMID: 9074931.
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3 Fields:
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HumansCells