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David Nguyen, MD, PhD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW
San Francisco CA 94143
Phone415-476-1528
ORCID ORCID Icon0000-0001-6808-2717 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UCSF, San Francisco, CA2020Clinical Instructor / Research Fellow
    UCSF, San Francisco, CA2017Fellowship, Infectious Diseases
    UCSF, San Francisco, CA2015Residency, Internal Medicine
    MIT, HST, Cambridge, MAPhD2008Materials Science and Medical Engineering
    Stanford University, Palo Alto, CAMD2012
    Collapse Awards and Honors
    UCSF2016Infectious Disease Outstanding Fellow Award
    Clinical Immunology Society 2018  - 2019CIS CSL Behring Fellowship
    California Institute of Regenerative Medicine (CIRM)2019  - 2021Alpha Stem Cell Clinic Fellowship
    NIH NIAID2020  - 2025K08 Mentored Clinical Scientist Research Career Development Award

    Collapse Overview 
    Collapse Overview
    David Nguyen PhD MD is a physician-scientist in Infectious Diseases and studies applications of genome editing in the immune system. He completed his PhD in Materials Science and Medical Engineering at MIT in the HST program, where he studied nanoparticle delivery of DNA and RNA to the immune system in the laboratory of Prof. Robert Langer with applications in DNA vaccines and immunostimulatory RNA vaccine adjuvants. He then went to Stanford University for medical school, and since 2012 has been at the UCSF Medical Center where he completed medical residency and a clinical fellowship in Infectious Diseases. He is currently an Assistant Adjunct Professor in the Department of Medicine at UCSF, and is a research fellow of the UCSF CIRM Alpha Stem Cell Clinic working in the laboratory of Prof. Alex Marson. Dr. Nguyen has clinical interests in treating infections in patients with compromised immune systems, and research interests in therapeutic gene editing to correct mutations that drive primary immunodeficiency (PID). Dr. Nguyen has leveraged his background in nucleic acid delivery to create new tools for high-efficiency non-viral CRISPR Cas9 gene editing in primary human immune cells. He is applying these tools to discover and model mutations associated with PIDs with an eventual goal of developing novel non-viral gene therapy strategies in human HSCs and T cells for treatment of patients living with a PID disease.

    Collapse Research 
    Collapse Research Activities and Funding
    CRISPR Editing of Primary Human Cells to Model and Correct Primary Immunodeficiency Mutations
    NIH NIAID 1K08AI153767-01Jul 1, 2020 - Jun 30, 2025

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A diagnostic host response biosignature for COVID-19 from RNA profiling of nasal swabs and blood. Sci Adv. 2021 02; 7(6). Ng DL, Granados AC, Santos YA, Servellita V, Goldgof GM, Meydan C, Sotomayor-Gonzalez A, Levine AG, Balcerek J, Han LM, Akagi N, Truong K, Neumann NM, Nguyen DN, Bapat SP, Cheng J, Martin CS, Federman S, Foox J, Gopez A, Li T, Chan R, Chu CS, Wabl CA, Gliwa AS, Reyes K, Pan CY, Guevara H, Wadford D, Miller S, Mason CE, Chiu CY. PMID: 33536218.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Functional CRISPR dissection of gene networks controlling human regulatory T cell identity. Nat Immunol. 2020 11; 21(11):1456-1466. Schumann K, Raju SS, Lauber M, Kolb S, Shifrut E, Cortez JT, Skartsis N, Nguyen VQ, Woo JM, Roth TL, Yu R, Nguyen MLT, Simeonov DR, Nguyen DN, Targ S, Gate RE, Tang Q, Bluestone JA, Spitzer MH, Ye CJ, Marson A. PMID: 32989329.
      View in: PubMed   Mentions: 1     Fields:    
    3. SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood. Nat Commun. 2020 09 17; 11(1):4698. Ng DL, Goldgof GM, Shy BR, Levine AG, Balcerek J, Bapat SP, Prostko J, Rodgers M, Coller K, Pearce S, Franz S, Du L, Stone M, Pillai SK, Sotomayor-Gonzalez A, Servellita V, Martin CSS, Granados A, Glasner DR, Han LM, Truong K, Akagi N, Nguyen DN, Neumann NM, Qazi D, Hsu E, Gu W, Santos YA, Custer B, Green V, Williamson P, Hills NK, Lu CM, Whitman JD, Stramer SL, Wang C, Reyes K, Hakim JMC, Sujishi K, Alazzeh F, Pham L, Thornborrow E, Oon CY, Miller S, Kurtz T, Simmons G, Hackett J, Busch MP, Chiu CY. PMID: 32943630.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    4. Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nat Biotechnol. 2020 10; 38(10):1174-1183. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32855547.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCellsPHPublic Health
    5. SARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area. medRxiv. 2020 May 25. Ng DL, Goldgof GM, Shy BR, Levine AG, Balcerek J, Bapat SP, Prostko J, Rodgers M, Coller K, Pearce S, Franz S, Du L, Stone M, Pillai SK, Sotomayor-Gonzalez A, Servellita V, Martin CSS, Granados A, Glasner DR, Han LM, Truong K, Akagi N, Nguyen DN, Neumann NM, Qazi D, Hsu E, Gu W, Santos YA, Custer B, Green V, Williamson P, Hills NK, Lu CM, Whitman JD, Stramer S, Wang C, Reyes K, Hakim JMC, Sujishi K, Alazzeh F, Pham L, Oon CY, Miller S, Kurtz T, Hackett J, Simmons G, Busch MP, Chiu CY. PMID: 32511477.
      View in: PubMed   Mentions:
    6. Test performance evaluation of SARS-CoV-2 serological assays. medRxiv. 2020 May 17. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. PMID: 32511497.
      View in: PubMed   Mentions:
    7. Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair. Nat Commun. 2020 04 30; 11(1):2109. Wienert B, Nguyen DN, Guenther A, Feng SJ, Locke MN, Wyman SK, Shin J, Kazane KR, Gregory GL, Carter MAM, Wright F, Conklin BR, Marson A, Richardson CD, Corn JE. PMID: 32355159.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    8. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. 2020 04 30; 181(3):728-744.e21. Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, Ye CJ, Roybal K, Shifrut E, Marson A. PMID: 32302591.
      View in: PubMed   Mentions: 5     Fields:    
    9. Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues. JCI Insight. 2019 12 19; 4(24). Lowe MM, Boothby I, Clancy S, Ahn RS, Liao W, Nguyen DN, Schumann K, Marson A, Mahuron KM, Kingsbury GA, Liu Z, Munoz Sandoval P, Rodriguez RS, Pauli ML, Taravati K, Arron ST, Neuhaus IM, Harris HW, Kim EA, Shin US, Krummel MF, Daud A, Scharschmidt TC, Rosenblum MD. PMID: 31852848.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency. Nat Biotechnol. 2020 01; 38(1):44-49. Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, Bluestone JA, Puck JM, Szoka FC, Marson A. PMID: 31819258.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    11. Reprogramming human T cell function and specificity with non-viral genome targeting. Nature. 2018 07; 559(7714):405-409. Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A. PMID: 29995861.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    12. Lipid-derived nanoparticles for immunostimulatory RNA adjuvant delivery. Proc Natl Acad Sci U S A. 2012 Apr 03; 109(14):E797-803. Nguyen DN, Mahon KP, Chikh G, Kim P, Chung H, Vicari AP, Love KT, Goldberg M, Chen S, Krieg AM, Chen J, Langer R, Anderson DG. PMID: 22421433.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    13. Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy. . 2009 Dec 28; 21(48):4947-4951. Sunshine J, Green JJ, Mahon KP, Yang F, Eltoukhy AA, Nguyen DN, Langer R, Anderson DG. PMID: 25165411.
      View in: PubMed   Mentions:
    14. Drug delivery-mediated control of RNA immunostimulation. Mol Ther. 2009 Sep; 17(9):1555-62. Nguyen DN, Chen SC, Lu J, Goldberg M, Kim P, Sprague A, Novobrantseva T, Sherman J, Shulga-Morskaya S, de Fougerolles A, Chen J, Langer R, Anderson DG. PMID: 19584813.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    15. A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery. Biotechnol Bioeng. 2009 Jul 01; 103(4):664-75. Nguyen DN, Kim P, Martínez-Sobrido L, Beitzel B, García-Sastre A, Langer R, Anderson DG. PMID: 19338049.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    16. Polymeric Materials for Gene Delivery and DNA Vaccination. . 2009 Feb 23; 21(8):847-867. Nguyen DN, Green JJ, Chan JM, Longer R, Anderson DG. PMID: 28413262.
      View in: PubMed   Mentions:
    17. A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol. 2008 May; 26(5):561-9. Akinc A, Zumbuehl A, Goldberg M, Leshchiner ES, Busini V, Hossain N, Bacallado SA, Nguyen DN, Fuller J, Alvarez R, Borodovsky A, Borland T, Constien R, de Fougerolles A, Dorkin JR, Narayanannair Jayaprakash K, Jayaraman M, John M, Koteliansky V, Manoharan M, Nechev L, Qin J, Racie T, Raitcheva D, Rajeev KG, Sah DW, Soutschek J, Toudjarska I, Vornlocher HP, Zimmermann TS, Langer R, Anderson DG. PMID: 18438401.
      View in: PubMed   Mentions: 301     Fields:    
    18. Enhancement of poly(orthoester) microspheres for DNA vaccine delivery by blending with poly(ethylenimine). Biomaterials. 2008 Jun; 29(18):2783-93. Nguyen DN, Raghavan SS, Tashima LM, Lin EC, Fredette SJ, Langer RS, Wang C. PMID: 18400294.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
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