Elizabeth Crouch, MD, PhD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-4110-9892 Additional info
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    Collapse Education and Training
    DePauw University, Greencastle, INBABiochemistry
    Columbia University, New York, NYMDMedicine
    Columbia University, New York, NYPhDNeuroscience
    University of California, San Francisco, San Francisco, CAResidencyPediatrics
    University of California, San Francisco, San Francisco, CAFellowshipNeonatology

    Collapse Overview 
    Collapse Overview
    I am a neuroscientist, a vascular biologist, and a physician in Neonatal-Perinatal medicine. My lab, the Neurovascular Development lab at crouchlab.ucsf.edu, studies how brain blood vessels grow and interact with other brain cells. In part, this interest is inspired from the preterm babies that I care for clinically. Approximately 20% of preterm babies born between 24-28 gestation weeks will develop germinal matrix hemorrhage (GMH). This hemorrhage can cause hydrocephalus, cerebral palsy, and death, and unfortunately there are currently no treatments. Our lab uses neuropathological specimens, flow cytometry (FACS), bioinformatics, and cell culture, including organoid models, to interrogate brain vascular biology. We are always interested in hiring motivated and talented individuals. Send an email to inquire; women and URM especially encouraged to apply. For fun, we run the BreakingDownBiology blog (also funded by UCSF ImmunoX) to explain exciting scientific journal articles with every day language.

    Collapse Research 
    Collapse Research Activities and Funding
    Mural stem cells in normal development and germinal matrix hemorrhage in the preterm human brain
    American Heart Association Career Development Award A137252Jul 1, 2021 - Jun 30, 2024
    Role: PI
    Stage-specific vulnerability of vascular stem cells in preterm brain hemorrhage
    California Institute for Regenerative Medicine Jul 1, 2021 - Jun 30, 2023
    Role: PI
    Mural stem cells in normal development and germinal matrix hemorrhage in the preterm human brain
    NIH K08NS116161Dec 1, 2020 - Nov 30, 2025
    Role: Principal Investigator
    New modalities to interrogate the human brain neurovacular unit
    University of California Physician Scientist Scholar Program Jul 1, 2020 - Jun 30, 2025
    Role: PI
    Immune cell and vascular interactions in the human blood brain barrier
    Hellman Family Clinical-Translational Research Development Award Jul 1, 2020 - Jun 30, 2021
    Role: PI
    Vascular development in the human brain
    NICHD Pediatric Scientist Development Program (PSDP) K12HD000850-34Jul 1, 2018 - Jun 30, 2020

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes. bioRxiv. 2021 Jan 18. Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Perez Y, Mostajo-Radji MA, Wang S, Velmeshev D, Salma J, Kumar GR, Pollen AA, Crouch EE, Ott M, Kriegstein AR. PMID: 33469577.
      View in: PubMed   Mentions:
    2. The Expanding Cell Diversity of the Brain Vasculature. Front Physiol. 2020; 11:600767. Ross JM, Kim C, Allen D, Crouch EE, Narsinh K, Cooke DL, Abla AA, Nowakowski TJ, Winkler EA. PMID: 33343397.
      View in: PubMed   Mentions: 3  
    3. Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Rep. 2020 10 13; 33(2):108256. Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J. PMID: 33053356.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Human organoids to model the developing human neocortex in health and disease. Brain Res. 2020 09 01; 1742:146803. Khakipoor S, Crouch EE, Mayer S. PMID: 32240655.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell Stem Cell. 2020 01 02; 26(1):48-63.e6. Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR. PMID: 31901251.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    6. FACS isolation of endothelial cells and pericytes from mouse brain microregions. Nat Protoc. 2018 04; 13(4):738-751. Crouch EE, Doetsch F. PMID: 29565899.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    7. Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Neurosci. 2015 Mar 18; 35(11):4528-39. Crouch EE, Liu C, Silva-Vargas V, Doetsch F. PMID: 25788671.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    8. Novel association of early onset hepatocellular carcinoma with transaldolase deficiency. JIMD Rep. 2014; 12:121-7. Leduc CA, Crouch EE, Wilson A, Lefkowitch J, Wamelink MM, Jakobs C, Salomons GS, Sun X, Shen Y, Chung WK. PMID: 24097415.
      View in: PubMed   Mentions: 10  
    9. Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging. Curr Opin Neurobiol. 2013 Dec; 23(6):935-42. Silva-Vargas V, Crouch EE, Doetsch F. PMID: 24090877.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    10. The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature. 2007 Jun 07; 447(7145):730-4. Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R. PMID: 17554310.
      View in: PubMed   Mentions: 147     Fields:    Translation:AnimalsCells
    11. Regulation of AID expression in the immune response. J Exp Med. 2007 May 14; 204(5):1145-56. Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montaño C, Feigenbaum L, Wilson P, Janz S, Papavasiliou FN, Casellas R. PMID: 17452520.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
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