Elizabeth Crouch, MD, PhD
Biography
DePauw University, Greencastle, IN | BA | | Biochemistry |
Columbia University, New York, NY | MD | | Medicine |
Columbia University, New York, NY | PhD | | Neuroscience |
University of California, San Francisco, San Francisco, CA | Residency | | Pediatrics |
University of California, San Francisco, San Francisco, CA | Fellowship | | Neonatology |
Rockefeller University | 2023 | | Leon Levy Neuroscience Awardee |
American Society for Clinical Investigation | 2023 | | Young Physician-Scientist Award |
Gordon Conference on Angiogenesis | 2023 | | Invited speaker |
NIH NIMH | 2023 | | New Innovator Award (DP2) |
International Vascular Biology Meeting | 2022 | | Discussion leader |
California Association of Neonatologists | 2020 | | Bhatt Ramanathan Scholarship Award for excellence in neonatology research |
UCSF | 2020 | | Physician Scientists Scholars Program |
Overview
I am a neuroscientist, a vascular biologist, and a physician in Neonatal-Perinatal medicine. My lab, the Neurovascular Development lab at crouchlab.ucsf.edu, studies how brain blood vessels grow and interact with other brain cells. In part, this interest is inspired from the preterm babies that I care for clinically. Approximately 20% of preterm babies born between 24-28 gestation weeks will develop germinal matrix hemorrhage (GMH). This hemorrhage can cause hydrocephalus, cerebral palsy, and death, and unfortunately there are currently no treatments. It remains unclear why vasculature in this developmental window is particularly sensitive. One critical barrier is the lack of a comprehensive understanding of the spatiotemporal dynamics of vascular cell development in the prenatal brain. Our research resolves around defining the stages of vascular stem cells in the developing brain and understanding the mechanisms that regulate their functions. We then apply this knowledge to produce novel technologies and therapeutic strategies for different brain hemorrhages in neonatal and pediatric patients. Towards these goals, we utilize neuropathological specimens, flow cytometry (FACS), bioinformatics, and cell culture, including organoid models. We are always interested in hiring motivated and talented individuals. Send an email to inquire; women and URM especially encouraged to apply. For fun, we run the BreakingDownBiology blog (also funded by UCSF ImmunoX) to explain exciting scientific journal articles with every day language. I also co-host "At the Bench: Neonatal Physician Scientists" for the Incubator Podcast network.
Research
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Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy. Cancer Discov. 2024 Oct 04; 14(10):1823-1837.
Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Oberheim Bush NA, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, Perry A, Dickinson PJ, Heimberger AB, Ashworth A, Crouch EE, Raleigh DR. PMID: 38742767; PMCID: PMC11452293.
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PubMed Mentions:
6 Fields:
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HumansAnimalsCells
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Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain. Nat Neurosci. 2024 Sep 30.
Chen J, Crouch EE, Zawadzki ME, Jacobs KA, Mayo LN, Choi JJ, Lin PY, Shaikh S, Tsui J, Gonzalez-Granero S, Waller S, Kelekar A, Kang G, Valenzuela EJ, Birrueta JO, Diafos LN, Wedderburn-Pugh K, Di Marco B, Xia W, Han CZ, Coufal NG, Glass CK, Fancy SPJ, Alfonso J, Kriegstein AR, Oldham MC, Garcia-Verdugo JM, Kutys ML, Lehtinen MK, Combes AJ, Huang EJ. PMID: 39349662.
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HumansAnimalsCells
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The molecular landscape of vascular cells in the human brain. Nat Rev Cardiol. 2024 Sep 20.
Crouch EE. PMID: 39304749.
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Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis. Neuro Oncol. 2024 Aug 29.
Mirchia K, Choudhury A, Joseph T, Birrueta JO, Phillips JJ, Bhaduri A, Crouch EE, Perry A, Raleigh DR. PMID: 39207122.
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Glioblastoma Neurovascular Progenitor Orchestrates Tumor Cell Type Diversity. bioRxiv. 2024 Jul 24.
Fazzari E, Azizad DJ, Yu K, Ge W, Li MX, Nano PR, Kan RL, Tum HA, Tse C, Bayley NA, Haka V, Cadet D, Perryman T, Soto JA, Wick B, Raleigh DR, Crouch EE, Patel KS, Liau LM, Deneen B, Nathanson DA, Bhaduri A. PMID: 39091877; PMCID: PMC11291138.
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Should neonatal-perinatal medicine move to two-year fellowships? J Perinatol. 2024 Aug; 44(8):1222-1227.
Shah S, Myers P, Enciso JM, Davis AS, Crouch EE, Scheurer AM, Song C, Lakshminrusimha S. PMID: 38851854.
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Humans
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A Vascular-Centric Approach to Autism Spectrum Disorders. Neurosci Insights. 2024; 19:26331055241235921.
Ouellette J, Crouch EE, Morel JL, Coelho-Santos V, Lacoste B. PMID: 38476695; PMCID: PMC10929024.
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Profiling human brain vascular cells using single-cell transcriptomics and organoids. Nat Protoc. 2024 Mar; 19(3):603-628.
Crouch EE, Diafos LN, Valenzuela EJ, Wedderburn-Pugh K, Birrueta JO, Caston J, Joseph T, Andrews MG, Bhaduri A, Huang EJ. PMID: 38102365.
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1 Fields:
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HumansCells
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Parents' Views on Autopsy, Organ Donation, and Research Donation After Neonatal Death. JAMA Netw Open. 2023 11 01; 6(11):e2341533.
Crouch EE, Damas C, Bartrug WC, Shamiyeh A, Scelfo M, Dreyfus M, Gano D, Segal S, Franck LS. PMID: 37930699; PMCID: PMC10628732.
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Humans
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LIF signaling regulates outer radial glial to interneuron fate during human cortical development. Cell Stem Cell. 2023 10 05; 30(10):1382-1391.e5.
Andrews MG, Siebert C, Wang L, White ML, Ross J, Morales R, Donnay M, Bamfonga G, Mukhtar T, McKinney AA, Gemenes K, Wang S, Bi Q, Crouch EE, Parikshak N, Panagiotakos G, Huang E, Bhaduri A, Kriegstein AR. PMID: 37673072; PMCID: PMC10591955.
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9 Fields:
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HumansCells
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Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis. Res Sq. 2023 Jul 26.
Raleigh D, Mirchia K, Choudhury A, Joseph T, Birrueta J, Phillips J, Bhaduri A, Crouch E, Perry A. PMID: 37546798; PMCID: PMC10402198.
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NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy. bioRxiv. 2023 Jul 11.
Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Bush NAO, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, Perry A, Dickinson PJ, Heimberger AB, Ashworth A, Crouch EE, Raleigh DR. PMID: 37503127; PMCID: PMC10369862.
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Disentangling brain vasculature in neurogenesis and neurodegeneration using single-cell transcriptomics. Trends Neurosci. 2023 07; 46(7):551-565.
Crouch EE, Joseph T, Marsan E, Huang EJ. PMID: 37210315; PMCID: PMC10560453.
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4 Fields:
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HumansCells
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A Case of Neonatal Lupus Presenting with Myocardial Dysfunction in the Absence of Congenital Heart Block (CHB): Clinical Management and Brief Literature Review of Neonatal Cardiac Lupus. Pediatr Cardiol. 2023 Mar; 44(3):736-739.
Jain S, Spadafora R, Maxwell S, Botas C, Nawaytou H, von Scheven E, Crouch EE. PMID: 36460799; PMCID: PMC9950208.
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2 Fields:
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Humans
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Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain. Cell. 2022 09 29; 185(20):3753-3769.e18.
Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-Granero S, Lozano JF, Vento M, Haeussler M, Paredes MF, Nakamura K, Garcia-Verdugo JM, Alvarez-Buylla A, Kriegstein AR, Huang EJ. PMID: 36179668; PMCID: PMC9550196.
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29 Fields:
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HumansCells
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Developmental dynamics of RNA translation in the human brain. Nat Neurosci. 2022 10; 25(10):1353-1365.
Duffy EE, Finander B, Choi G, Carter AC, Pritisanac I, Alam A, Luria V, Karger A, Phu W, Sherman MA, Assad EG, Pajarillo N, Khitun A, Crouch EE, Ganesh S, Chen J, Berger B, Sestan N, O'Donnell-Luria A, Huang EJ, Griffith EC, Forman-Kay JD, Moses AM, Kalish BT, Greenberg ME. PMID: 36171426; PMCID: PMC10198132.
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37 Fields:
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HumansCells
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Tropism of SARS-CoV-2 for human cortical astrocytes. Proc Natl Acad Sci U S A. 2022 07 26; 119(30):e2122236119.
Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, Mostajo-Radji MA, de Majo M, Donohue KC, Shin D, Salma J, Pollen AA, Nowakowski TJ, Ullian E, Kumar GR, Winkler EA, Crouch EE, Ott M, Kriegstein AR. PMID: 35858406; PMCID: PMC9335272.
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56 Fields:
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HumansCells
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Individual human cortical progenitors can produce excitatory and inhibitory neurons. Nature. 2022 01; 601(7893):397-403.
Delgado RN, Allen DE, Keefe MG, Mancia Leon WR, Ziffra RS, Crouch EE, Alvarez-Buylla A, Nowakowski TJ. PMID: 34912114; PMCID: PMC8994470.
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49 Fields:
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HumansCells
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24
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Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Rep. 2020 10 13; 33(2):108256.
Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J. PMID: 33053356.
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PubMed Mentions:
19 Fields:
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HumansAnimalsCells
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Human organoids to model the developing human neocortex in health and disease. Brain Res. 2020 09 01; 1742:146803.
Khakipoor S, Crouch EE, Mayer S. PMID: 32240655; PMCID: PMC7352040.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell Stem Cell. 2020 01 02; 26(1):48-63.e6.
Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR. PMID: 31901251; PMCID: PMC7029801.
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PubMed Mentions:
142 Fields:
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HumansCells
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Prevalence of adverse childhood experiences (ACEs) among US children. Child Abuse Negl. 2019 06; 92:209-218.
Crouch E, Probst JC, Radcliff E, Bennett KJ, McKinney SH. PMID: 31003066.
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76 Fields:
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Humans
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FACS isolation of endothelial cells and pericytes from mouse brain microregions. Nat Protoc. 2018 04; 13(4):738-751.
Crouch EE, Doetsch F. PMID: 29565899.
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61 Fields:
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AnimalsCells
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Examining the association between adverse childhood experiences and smoking-exacerbated illnesses. Public Health. 2018 Apr; 157:62-68.
Crouch E, Radcliff E, Strompolis M, Wilson A. PMID: 29500945.
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PubMed Mentions:
4 Fields:
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Humans
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Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Neurosci. 2015 Mar 18; 35(11):4528-39.
Crouch EE, Liu C, Silva-Vargas V, Doetsch F. PMID: 25788671; PMCID: PMC4363382.
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51 Fields:
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AnimalsCells
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Novel association of early onset hepatocellular carcinoma with transaldolase deficiency. JIMD Rep. 2014; 12:121-7.
Leduc CA, Crouch EE, Wilson A, Lefkowitch J, Wamelink MM, Jakobs C, Salomons GS, Sun X, Shen Y, Chung WK. PMID: 24097415; PMCID: PMC3897795.
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17
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Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging. Curr Opin Neurobiol. 2013 Dec; 23(6):935-42.
Silva-Vargas V, Crouch EE, Doetsch F. PMID: 24090877.
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75 Fields:
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HumansAnimalsCells
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The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature. 2007 Jun 07; 447(7145):730-4.
Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R. PMID: 17554310.
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PubMed Mentions:
171 Fields:
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AnimalsCells
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Regulation of AID expression in the immune response. J Exp Med. 2007 May 14; 204(5):1145-56.
Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montaño C, Feigenbaum L, Wilson P, Janz S, Papavasiliou FN, Casellas R. PMID: 17452520; PMCID: PMC2118564.
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PubMed Mentions:
135 Fields:
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AnimalsCells
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Interactions of recombinant human pulmonary surfactant protein D and SP-D multimers with influenza A. Am J Physiol. 1996 Nov; 271(5 Pt 1):L753-62.
Hartshorn K, Chang D, Rust K, White M, Heuser J, Crouch E. PMID: 8944718.
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PubMed Mentions:
48 Fields:
Translation:
HumansAnimalsCells
This graph shows the total number of publications by year. To see the data as text,
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Year | Publications |
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1996 | 1 |
2007 | 2 |
2013 | 2 |
2015 | 1 |
2018 | 2 |
2019 | 1 |
2020 | 4 |
2021 | 1 |
2022 | 4 |
2023 | 6 |
2024 | 7 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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