Elizabeth Crouch, MD, PhD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-4110-9892 Additional info
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    Collapse Biography 
    Collapse Education and Training
    DePauw University, Greencastle, INBABiochemistry
    Columbia University, New York, NYMDMedicine
    Columbia University, New York, NYPhDNeuroscience
    University of California, San Francisco, San Francisco, CAResidencyPediatrics
    University of California, San Francisco, San Francisco, CAFellowshipNeonatology
    Collapse Awards and Honors
    American Society for Clinical Investigation2023Young Physician-Scientist Award
    Gordon Conference on Angiogenesis2023Invited speaker
    NIH NIMH2023New Innovator Award (DP2)
    International Vascular Biology Meeting2022Discussion leader
    California Association of Neonatologists2020Bhatt Ramanathan Scholarship Award for excellence in neonatology research
    UCSF2020Physician Scientists Scholars Program

    Collapse Overview 
    Collapse Overview
    I am a neuroscientist, a vascular biologist, and a physician in Neonatal-Perinatal medicine. My lab, the Neurovascular Development lab at crouchlab.ucsf.edu, studies how brain blood vessels grow and interact with other brain cells. In part, this interest is inspired from the preterm babies that I care for clinically. Approximately 20% of preterm babies born between 24-28 gestation weeks will develop germinal matrix hemorrhage (GMH). This hemorrhage can cause hydrocephalus, cerebral palsy, and death, and unfortunately there are currently no treatments. It remains unclear why vasculature in this developmental window is particularly sensitive. One critical barrier is the lack of a comprehensive understanding of the spatiotemporal dynamics of vascular cell development in the prenatal brain. Our research resolves around defining the stages of vascular stem cells in the developing brain and understanding the mechanisms that regulate their functions. We then apply this knowledge to produce novel technologies and therapeutic strategies for different brain hemorrhages in neonatal and pediatric patients. Towards these goals, we utilize neuropathological specimens, flow cytometry (FACS), bioinformatics, and cell culture, including organoid models. We are always interested in hiring motivated and talented individuals. Send an email to inquire; women and URM especially encouraged to apply. For fun, we run the BreakingDownBiology blog (also funded by UCSF ImmunoX) to explain exciting scientific journal articles with every day language. I also co-host "At the Bench: Neonatal Physician Scientists" for the Incubator Podcast network.

    Collapse Research 
    Collapse Research Activities and Funding
    Vascular mural cells in the development of the blood brain barrier
    NIH DP2MH136391Sep 1, 2023 - Aug 31, 2026
    Role: Principal Investigator
    Harnessing vascular stem cells to grow and protect the human brain
    California Institute for Regenerative Medicine DISC0Jul 1, 2023 - May 31, 2026
    Role: PI
    A vascular strategy to ameliorate germinal matrix hemorrhage in preterm infants
    Burroughs Wellcome Fund Next Gen PregnancyJun 1, 2023 - May 31, 2027
    Role: PI
    Mural cells in normal development and germinal matrix hemorrhage in the preterm human brain
    American Heart Association Career Development Award A137252Jul 1, 2021 - Jun 30, 2024
    Role: PI
    Stage-specific vulnerability of vascular stem cells in preterm brain hemorrhage
    California Institute for Regenerative Medicine Jul 1, 2021 - Jun 30, 2023
    Role: PI
    Mural stem cells in normal development and germinal matrix hemorrhage in the preterm human brain
    NIH K08NS116161Dec 1, 2020 - Nov 30, 2025
    Role: Principal Investigator
    New modalities to interrogate the human brain neurovacular unit
    University of California Physician Scientist Scholar Program Jul 1, 2020 - Jun 30, 2025
    Role: PI
    Immune cell and vascular interactions in the human blood brain barrier
    Hellman Family Clinical-Translational Research Development Award Jul 1, 2020 - Jun 30, 2021
    Role: PI
    Vascular development in the human brain
    NICHD Pediatric Scientist Development Program (PSDP) K12HD000850-34Jul 1, 2018 - Jun 30, 2020

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Vascular-Centric Approach to Autism Spectrum Disorders. Neurosci Insights. 2024; 19:26331055241235921. Ouellette J, Crouch EE, Morel JL, Coelho-Santos V, Lacoste B. PMID: 38476695; PMCID: PMC10929024.
      View in: PubMed   Mentions:
    2. Profiling human brain vascular cells using single-cell transcriptomics and organoids. Nat Protoc. 2024 Mar; 19(3):603-628. Crouch EE, Diafos LN, Valenzuela EJ, Wedderburn-Pugh K, Birrueta JO, Caston J, Joseph T, Andrews MG, Bhaduri A, Huang EJ. PMID: 38102365.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Parents' Views on Autopsy, Organ Donation, and Research Donation After Neonatal Death. JAMA Netw Open. 2023 Nov 01; 6(11):e2341533. Crouch EE, Damas C, Bartrug WC, Shamiyeh A, Scelfo M, Dreyfus M, Gano D, Segal S, Franck LS. PMID: 37930699; PMCID: PMC10628732.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. LIF signaling regulates outer radial glial to interneuron fate during human cortical development. Cell Stem Cell. 2023 10 05; 30(10):1382-1391.e5. Andrews MG, Siebert C, Wang L, White ML, Ross J, Morales R, Donnay M, Bamfonga G, Mukhtar T, McKinney AA, Gemenes K, Wang S, Bi Q, Crouch EE, Parikshak N, Panagiotakos G, Huang E, Bhaduri A, Kriegstein AR. PMID: 37673072; PMCID: PMC10591955.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Meningeal solitary fibrous tumor cell states phenocopy cerebral vascular development and homeostasis. Res Sq. 2023 Jul 26. Raleigh D, Mirchia K, Choudhury A, Joseph T, Birrueta J, Phillips J, Bhaduri A, Crouch E, Perry A. PMID: 37546798; PMCID: PMC10402198.
      View in: PubMed   Mentions:
    6. NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy. bioRxiv. 2023 Jul 11. Choudhury A, Cady MA, Lucas CG, Najem H, Phillips JJ, Palikuqi B, Zakimi N, Joseph T, Birrueta JO, Chen WC, Bush NAO, Hervey-Jumper SL, Klein OD, Toedebusch CM, Horbinski CM, Magill ST, Bhaduri A, Perry A, Dickinson PJ, Heimberger AB, Ashworth A, Crouch EE, Raleigh DR. PMID: 37503127; PMCID: PMC10369862.
      View in: PubMed   Mentions:
    7. Disentangling brain vasculature in neurogenesis and neurodegeneration using single-cell transcriptomics. Trends Neurosci. 2023 07; 46(7):551-565. Crouch EE, Joseph T, Marsan E, Huang EJ. PMID: 37210315; PMCID: PMC10560453.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. A Case of Neonatal Lupus Presenting with Myocardial Dysfunction in the Absence of Congenital Heart Block (CHB): Clinical Management and Brief Literature Review of Neonatal Cardiac Lupus. Pediatr Cardiol. 2023 Mar; 44(3):736-739. Jain S, Spadafora R, Maxwell S, Botas C, Nawaytou H, von Scheven E, Crouch EE. PMID: 36460799; PMCID: PMC9950208.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain. Cell. 2022 09 29; 185(20):3753-3769.e18. Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-Granero S, Lozano JF, Vento M, Haeussler M, Paredes MF, Nakamura K, Garcia-Verdugo JM, Alvarez-Buylla A, Kriegstein AR, Huang EJ. PMID: 36179668; PMCID: PMC9550196.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    10. Developmental dynamics of RNA translation in the human brain. Nat Neurosci. 2022 10; 25(10):1353-1365. Duffy EE, Finander B, Choi G, Carter AC, Pritisanac I, Alam A, Luria V, Karger A, Phu W, Sherman MA, Assad EG, Pajarillo N, Khitun A, Crouch EE, Ganesh S, Chen J, Berger B, Sestan N, O'Donnell-Luria A, Huang EJ, Griffith EC, Forman-Kay JD, Moses AM, Kalish BT, Greenberg ME. PMID: 36171426; PMCID: PMC10198132.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    11. Tropism of SARS-CoV-2 for human cortical astrocytes. Proc Natl Acad Sci U S A. 2022 07 26; 119(30):e2122236119. Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, Mostajo-Radji MA, de Majo M, Donohue KC, Shin D, Salma J, Pollen AA, Nowakowski TJ, Ullian E, Kumar GR, Winkler EA, Crouch EE, Ott M, Kriegstein AR. PMID: 35858406; PMCID: PMC9335272.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    12. Individual human cortical progenitors can produce excitatory and inhibitory neurons. Nature. 2022 01; 601(7893):397-403. Delgado RN, Allen DE, Keefe MG, Mancia Leon WR, Ziffra RS, Crouch EE, Alvarez-Buylla A, Nowakowski TJ. PMID: 34912114; PMCID: PMC8994470.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    13. The Expanding Cell Diversity of the Brain Vasculature. Front Physiol. 2020; 11:600767. Ross JM, Kim C, Allen D, Crouch EE, Narsinh K, Cooke DL, Abla AA, Nowakowski TJ, Winkler EA. PMID: 33343397; PMCID: PMC7744630.
      View in: PubMed   Mentions: 22  
    14. Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Rep. 2020 10 13; 33(2):108256. Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J. PMID: 33053356.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    15. Human organoids to model the developing human neocortex in health and disease. Brain Res. 2020 09 01; 1742:146803. Khakipoor S, Crouch EE, Mayer S. PMID: 32240655; PMCID: PMC7352040.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    16. Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell Stem Cell. 2020 01 02; 26(1):48-63.e6. Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR. PMID: 31901251; PMCID: PMC7029801.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    17. FACS isolation of endothelial cells and pericytes from mouse brain microregions. Nat Protoc. 2018 04; 13(4):738-751. Crouch EE, Doetsch F. PMID: 29565899.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    18. Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Neurosci. 2015 Mar 18; 35(11):4528-39. Crouch EE, Liu C, Silva-Vargas V, Doetsch F. PMID: 25788671; PMCID: PMC4363382.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    19. Novel association of early onset hepatocellular carcinoma with transaldolase deficiency. JIMD Rep. 2014; 12:121-7. Leduc CA, Crouch EE, Wilson A, Lefkowitch J, Wamelink MM, Jakobs C, Salomons GS, Sun X, Shen Y, Chung WK. PMID: 24097415; PMCID: PMC3897795.
      View in: PubMed   Mentions: 17  
    20. Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging. Curr Opin Neurobiol. 2013 Dec; 23(6):935-42. Silva-Vargas V, Crouch EE, Doetsch F. PMID: 24090877.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    21. The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature. 2007 Jun 07; 447(7145):730-4. Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R. PMID: 17554310.
      View in: PubMed   Mentions: 172     Fields:    Translation:AnimalsCells
    22. Regulation of AID expression in the immune response. J Exp Med. 2007 May 14; 204(5):1145-56. Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montaño C, Feigenbaum L, Wilson P, Janz S, Papavasiliou FN, Casellas R. PMID: 17452520; PMCID: PMC2118564.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
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