Elizabeth Crouch, MD, PhD
Biography
| DePauw University, Greencastle, IN | BA | | Biochemistry |
| Columbia University, New York, NY | MD | | Medicine |
| Columbia University, New York, NY | PhD | | Neuroscience |
| University of California, San Francisco, San Francisco, CA | Residency | | Pediatrics |
| University of California, San Francisco, San Francisco, CA | Fellowship | | Neonatology |
Overview
I am a neuroscientist, a vascular biologist, and a physician in Neonatal-Perinatal medicine. My lab, the Neurovascular Development lab at crouchlab.ucsf.edu, studies how brain blood vessels grow and interact with other brain cells. In part, this interest is inspired from the preterm babies that I care for clinically. Approximately 20% of preterm babies born between 24-28 gestation weeks will develop germinal matrix hemorrhage (GMH). This hemorrhage can cause hydrocephalus, cerebral palsy, and death, and unfortunately there are currently no treatments. Our lab uses neuropathological specimens, flow cytometry (FACS), bioinformatics, and cell culture, including organoid models, to interrogate brain vascular biology. We are always interested in hiring motivated and talented individuals. Send an email to inquire; women and URM especially encouraged to apply. For fun, we run the BreakingDownBiology blog (also funded by UCSF ImmunoX) to explain exciting scientific journal articles with every day language.
Research
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Bibliographic
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
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Individual human cortical progenitors can produce excitatory and inhibitory neurons. Nature. 2022 01; 601(7893):397-403.
Delgado RN, Allen DE, Keefe MG, Mancia Leon WR, Ziffra RS, Crouch EE, Alvarez-Buylla A, Nowakowski TJ. PMID: 34912114; PMCID: PMC8994470.
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Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes. bioRxiv. 2021 Jan 18.
Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Perez Y, Mostajo-Radji MA, Wang S, Velmeshev D, Salma J, Kumar GR, Pollen AA, Crouch EE, Ott M, Kriegstein AR. PMID: 33469577; PMCID: PMC7814814.
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Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Rep. 2020 10 13; 33(2):108256.
Di Marco B, Crouch EE, Shah B, Duman C, Paredes MF, Ruiz de Almodovar C, Huang EJ, Alfonso J. PMID: 33053356.
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2 Fields:
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HumansAnimalsCells
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Human organoids to model the developing human neocortex in health and disease. Brain Res. 2020 09 01; 1742:146803.
Khakipoor S, Crouch EE, Mayer S. PMID: 32240655; PMCID: PMC7352040.
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4 Fields:
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HumansCells
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Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma. Cell Stem Cell. 2020 01 02; 26(1):48-63.e6.
Bhaduri A, Di Lullo E, Jung D, Müller S, Crouch EE, Espinosa CS, Ozawa T, Alvarado B, Spatazza J, Cadwell CR, Wilkins G, Velmeshev D, Liu SJ, Malatesta M, Andrews MG, Mostajo-Radji MA, Huang EJ, Nowakowski TJ, Lim DA, Diaz A, Raleigh DR, Kriegstein AR. PMID: 31901251; PMCID: PMC7029801.
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29 Fields:
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HumansCells
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FACS isolation of endothelial cells and pericytes from mouse brain microregions. Nat Protoc. 2018 04; 13(4):738-751.
Crouch EE, Doetsch F. PMID: 29565899.
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18 Fields:
Translation:
AnimalsCells
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Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J Neurosci. 2015 Mar 18; 35(11):4528-39.
Crouch EE, Liu C, Silva-Vargas V, Doetsch F. PMID: 25788671; PMCID: PMC4363382.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Novel association of early onset hepatocellular carcinoma with transaldolase deficiency. JIMD Rep. 2014; 12:121-7.
Leduc CA, Crouch EE, Wilson A, Lefkowitch J, Wamelink MM, Jakobs C, Salomons GS, Sun X, Shen Y, Chung WK. PMID: 24097415; PMCID: PMC3897795.
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10
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Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging. Curr Opin Neurobiol. 2013 Dec; 23(6):935-42.
Silva-Vargas V, Crouch EE, Doetsch F. PMID: 24090877.
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PubMed Mentions:
54 Fields:
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HumansAnimalsCells
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The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature. 2007 Jun 07; 447(7145):730-4.
Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R. PMID: 17554310.
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147 Fields:
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AnimalsCells
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Regulation of AID expression in the immune response. J Exp Med. 2007 May 14; 204(5):1145-56.
Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montaño C, Feigenbaum L, Wilson P, Janz S, Papavasiliou FN, Casellas R. PMID: 17452520; PMCID: PMC2118564.
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PubMed Mentions:
116 Fields:
Translation:
AnimalsCells
This graph shows the total number of publications by year. To see the data as text,
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| Year | Publications |
|---|
| 2007 | 2 |
| 2013 | 2 |
| 2015 | 1 |
| 2018 | 1 |
| 2020 | 4 |
| 2021 | 2 |
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
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