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Neil Trivedi, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Phone415-221-4810 ext. 4881
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    Collapse Biography 
    Collapse Education and Training
    UCSF, San Francisco, CAFellowship2007Pulmonary/Critical Care
    UCSF, San Francisco, CAResidency 2004Internal Medicine
    UCLA, Los Angeles, CAMD2001Medical School
    University of Pennsylvania, Philadelphia, PABA1996Biology and Psychology

    Collapse Research 
    Collapse Research Activities and Funding
    A Genomic, Proteomic, and Clinical Analysis of Mast Cell Proteases
    Veterans Affairs CDA-2Jul 1, 2009 - Jun 30, 2014
    Role: PI
    Biomarkers for early detection of lung allograft rejection
    NIH F32HL090279Jan 1, 2008 - Dec 31, 2008
    Role: PI

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, Orozco LD, Christensen E, Wong M, Corpuz R, Hang JQ, Lutman J, Sukumaran S, Wu Y, Ubhayakar S, Liang X, Schwartz LB, Babina M, Woodruff PG, Fahy JV, Ahuja R, Caughey GH, Kusi A, Dennis MS, Eigenbrot C, Kirchhofer D, Austin CD, Wu LC, Koerber JT, Lee WP, Yaspan BL, Alatsis KR, Arron JR, Lazarus RA, Yi T. An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell. 2019 Oct 03; 179(2):417-431.e19. PMID: 31585081.
      View in: PubMed
    2. Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD. Gene signatures common to allograft rejection are associated with lymphocytic bronchitis. Clin Transplant. 2019 May; 33(5):e13515. PMID: 30849195.
      View in: PubMed
    3. David Choy, Neil Trivedi, Amy Dressen, Magda Babina, Rahul Ahuja, Tangsheng Yi, Janet Jackman, Guiquan Ji, Jason Hackney, Luz Orozco-Guerra, Diana Chang, George Caughey, Brian Yaspan. Tryptase loss-of-function mutations reduce tryptase expression and predict asthmatic response to anti-IgE therapy. 2018 Sep 15; oa1652.
      View in: Publisher Site
    4. Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, Ho N, Zhao M, Liu Y, O'Connell MP, Trivedi NN, Nelson C, DiMaggio T, Jones N, Matthews H, Lewis KL, Oler AJ, Carlson RJ, Arkwright PD, Hong C, Agama S, Wilson TM, Tucker S, Zhang Y, McElwee JJ, Pao M, Glover SC, Rothenberg ME, Hohman RJ, Stone KD, Caughey GH, Heller T, Metcalfe DD, Biesecker LG, Schwartz LB, Milner JD. Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Nat Genet. 2016 12; 48(12):1564-1569. PMID: 27749843.
      View in: PubMed
    5. Babina M, Guhl S, Artuc M, Trivedi NN, Zuberbier T. Phenotypic variability in human skin mast cells. Exp Dermatol. 2016 06; 25(6):434-9. PMID: 26706922.
      View in: PubMed
    6. J.R. Greenland, C.M. Wong, R. Ahuja, M. Gottschall, N.N. Trivedi, J. Kukreja, S.R. Hays, J.P. Singer, J.A. Golden, Q. Tang, G.H. Caughey. (828) CD25+ Regulatory T Cells in Bronchoalveolar Lavage Fluid Are Associated with Lung Allograft Rejection. 2014 Apr 1; 33(4):s300.
      View in: Publisher Site
    7. Greenland JR, Jewell NP, Gottschall M, Trivedi NN, Kukreja J, Hays SR, Singer JP, Golden JA, Caughey GH. Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection. Am J Transplant. 2014 Apr; 14(4):831-40. PMID: 24512389.
      View in: PubMed
    8. Raman K, Trivedi NN, Raymond WW, Ganesan R, Kirchhofer D, Verghese GM, Craik CS, Schneider EL, Nimishakavi S, Caughey GH. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. J Biol Chem. 2013 Apr 12; 288(15):10588-98. PMID: 23447538.
      View in: PubMed
    9. Neil N. Trivedi, George H. Caughey. Chapter 592 ?-Tryptase. 2013 Jan 1; 2694-2697.
      View in: Publisher Site
    10. Neil N. Trivedi, George H. Caughey. Chapter 591 Human a-, ß- and d-Tryptases. 2013 Jan 1; 2683-2693.
      View in: Publisher Site
    11. Greenland JR, Jones KD, Hays SR, Golden JA, Urisman A, Jewell NP, Caughey GH, Trivedi NN. Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2013 Feb 15; 187(4):417-23. PMID: 23239157.
      View in: PubMed
    12. Neil Trivedi, Magda Babina, Rahul Ahuja, Sven Guhl, Torsten Zuberbier, George Caughey. Inheritance Of Tryptase Genes With Loss-Of-Function Mutations Correlates With Reduced Tryptase Activity In Human Skin Mast Cells. 2012 May 1; a5734-a5734.
      View in: Publisher Site
    13. Raymond WW, Trivedi NN, Makarova A, Ray M, Craik CS, Caughey GH. How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution. J Immunol. 2010 Nov 01; 185(9):5360-8. PMID: 20889553.
      View in: PubMed
    14. Neil Trivedi, Bani Tamraz, Esteban Burchard, Pui-Yan Kwok, George H. Caughey. Loss-of-function Tryptase Variants Are Common In African-American Asthmatic And Non-asthmatic Populations. 2010 May 1; a6786-a6786.
      View in: Publisher Site
    15. Trivedi NN, Caughey GH. Mast cell peptidases: chameleons of innate immunity and host defense. Am J Respir Cell Mol Biol. 2010 Mar; 42(3):257-67. PMID: 19933375.
      View in: PubMed
    16. Trivedi NN, Tamraz B, Chu C, Kwok PY, Caughey GH. Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. J Allergy Clin Immunol. 2009 Nov; 124(5):1099-105.e1-4. PMID: 19748655.
      View in: PubMed
    17. WW Raymond, NN Trivedi, A Makarova, GH Caughey. How Peptidases Evolve: Acquisition of Cathepsin G Tryptic Activity in Primates by Missense Mutation. 2009 Apr 1; a3710.
      View in: Publisher Site
    18. N. Trivedi, B. Tamraz, P.Y. Kwok, G.H. Caughey. An Inactivating, Frame-shifted Mutation of ,III Tryptase is Common in People of Northern and Western European Ancestory. 2009 Mar 1; 123(3):728-729.
      View in: Publisher Site
    19. Caughey GH, Beauchamp J, Schlatter D, Raymond WW, Trivedi NN, Banner D, Mauser H, Fingerle J. Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases. J Biol Chem. 2008 May 16; 283(20):13943-51. PMID: 18353771.
      View in: PubMed
    20. Trivedi NN, Raymond WW, Caughey GH. Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution. J Allergy Clin Immunol. 2008 May; 121(5):1262-8. PMID: 18325577.
      View in: PubMed
    21. Trivedi NN, Tong Q, Raman K, Bhagwandin VJ, Caughey GH. Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates. J Immunol. 2007 Nov 01; 179(9):6072-9. PMID: 17947681.
      View in: PubMed
    22. Haberer J, Trivedi NN, Kohlwes J, Tierney L. Clinical problem-solving. A gut feeling. N Engl J Med. 2003 Jul 03; 349(1):73-8. PMID: 12840095.
      View in: PubMed