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Oren Rosenberg, MD, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Phone415-514-0412
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    Collapse Biography 
    Collapse Education and Training
    Yale University School of MedicineMD/PhD2007
    Brigham and Women's HospitalInternship and Residency2009Internal Medicine
    University of California, San FranciscoFellowship2013Internal Medicine, Division of Infectious Diseases

    Collapse Overview 
    Collapse Overview
    I am a physician-scientist who studies and treats infectious diseases. The goal of my laboratory is to discover and exploit molecular vulnerabilities in bacteria in order to design faster, cheaper, less toxic and more effective therapeutics to treat life-threatening infections.

    Collapse Research 
    Collapse Research Activities and Funding
    Clinical translation of D-amino acid derived PET tracers for imaging spinalinfection
    NIH/NIBIB R01EB024014Sep 20, 2017 - Jun 30, 2021
    Role: Co-Principal Investigator
    Protein secretion in bacterial pathogens
    NIH/NIAID R01AI128214May 8, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Structural and functional studies of M. tuberculosis type VII secretion
    NIH/NIAID K08AI091656Sep 16, 2011 - Aug 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Poweleit N, Czudnochowski N, Nakagawa R, Trinidad D, Murphy KC, Sassetti CM, Rosenberg OS. The structure of the endogenous ESX-3 secretion system. Elife. 2019 Dec 30; 8. PMID: 31886769.
      View in: PubMed
    2. Stewart MN, Parker MFL, Jivan S, Luu JM, Huynh TL, Schulte B, Seo Y, Blecha JE, Villanueva-Meyer JE, Flavell RR, VanBrocklin HF, Ohliger MA, Rosenberg O, Wilson DM. High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection. ACS Infect Dis. 2020 Jan 10; 6(1):43-49. PMID: 31697062.
      View in: PubMed
    3. Qu J, Prasad NK, Yu MA, Chen S, Lyden A, Herrera N, Silvis MR, Crawford E, Looney MR, Peters JM, Rosenberg OS. Modulating Pathogenesis with Mobile-CRISPRi. J Bacteriol. 2019 Nov 15; 201(22). PMID: 31481541.
      View in: PubMed
    4. Fay A, Czudnochowski N, Rock JM, Johnson JR, Krogan NJ, Rosenberg O, Glickman MS. Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria. mBio. 2019 06 25; 10(3). PMID: 31239378.
      View in: PubMed
    5. Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T. Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs. Nat Commun. 2019 05 09; 10(1):2127. PMID: 31073154.
      View in: PubMed
    6. Peters JM, Koo BM, Patino R, Heussler GE, Hearne CC, Qu J, Inclan YF, Hawkins JS, Lu CHS, Silvis MR, Harden MM, Osadnik H, Peters JE, Engel JN, Dutton RJ, Grossman AD, Gross CA, Rosenberg OS. Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi. Nat Microbiol. 2019 02; 4(2):244-250. PMID: 30617347.
      View in: PubMed
    7. Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM. [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism. ACS Infect Dis. 2018 07 13; 4(7):1067-1072. PMID: 29712422.
      View in: PubMed
    8. Sriram R, Sun J, Villanueva-Meyer J, Mutch C, De Los Santos J, Peters J, Korenchan DE, Neumann K, Van Criekinge M, Kurhanewicz J, Rosenberg O, Wilson D, Ohliger MA. Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate. ACS Infect Dis. 2018 05 11; 4(5):797-805. PMID: 29405697.
      View in: PubMed
    9. Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM. Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. Sci Rep. 2017 08 11; 7(1):7903. PMID: 28801560.
      View in: PubMed
    10. Elwell CA, Czudnochowski N, von Dollen J, Johnson JR, Nakagawa R, Mirrashidi K, Krogan NJ, Engel JN, Rosenberg OS. Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction. Elife. 2017 03 02; 6. PMID: 28252385.
      View in: PubMed
    11. Mirrashidi KM, Elwell CA, Verschueren E, Johnson JR, Frando A, Von Dollen J, Rosenberg O, Gulbahce N, Jang G, Johnson T, Jäger S, Gopalakrishnan AM, Sherry J, Dunn JD, Olive A, Penn B, Shales M, Cox JS, Starnbach MN, Derre I, Valdivia R, Krogan NJ, Engel J. Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection. Cell Host Microbe. 2015 Jul 08; 18(1):109-21. PMID: 26118995.
      View in: PubMed
    12. Rosenberg OS, Dovala D, Li X, Connolly L, Bendebury A, Finer-Moore J, Holton J, Cheng Y, Stroud RM, Cox JS. Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell. 2015 Apr 23; 161(3):501-512. PMID: 25865481.
      View in: PubMed
    13. Lohse MB, Rosenberg OS, Cox JS, Stroud RM, Finer-Moore JS, Johnson AD. Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10404-10. PMID: 24994900.
      View in: PubMed
    14. Malak Abedalthagafi, Oren Rosenberg, Steve Miller. First report of tenosynovitis in an immunocompetent person caused by Mycobacterium heraklionense. JMM Case Reports. 2014 Jun 1; 1(2).
      View in: Publisher Site
    15. Hadjivassiliou H, Rosenberg OS, Guthrie C. The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing. RNA. 2014 May; 20(5):656-69. PMID: 24681967.
      View in: PubMed
    16. Dustin Dovala, Oren S. Rosenberg, Jeffery S. Cox. Molecular Determinants of Substrate Specificity in Type VII Secretion Systems. Biophysical Journal. 2014 Jan 1; 106(2):474a.
      View in: Publisher Site
    17. Scharschmidt TC, Amerson EH, Rosenberg OS, Jacobs RA, McCalmont TH, Shinkai K. Immune reconstitution reactions in human immunodeficiency virus-negative patients: report of a case and review of the literature. JAMA Dermatol. 2013 Jan; 149(1):74-8. PMID: 23324760.
      View in: PubMed
    18. Luke H. Chao, Margaret M. Stratton, Il-Hyung Lee, Oren S. Rosenberg, Joshua Levitz, Daniel J. Mandell, Tanja Kortemme, Jay T. Groves, Howard Schulman, John Kuriyan. A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme. Cell. 2011 Oct 1; 147(3):704.
      View in: Publisher Site
    19. Chao LH, Stratton MM, Lee IH, Rosenberg OS, Levitz J, Mandell DJ, Kortemme T, Groves JT, Schulman H, Kuriyan J. A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell. 2011 Sep 02; 146(5):732-45. PMID: 21884935.
      View in: PubMed
    20. Rosenberg OS, Dovey C, Tempesta M, Robbins RA, Finer-Moore JS, Stroud RM, Cox JS. EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13450-5. PMID: 21795602.
      View in: PubMed
    21. Rosenberg OS, Deindl S, Comolli LR, Hoelz A, Downing KH, Nairn AC, Kuriyan J. Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II. FEBS J. 2006 Feb; 273(4):682-94. PMID: 16441656.
      View in: PubMed
    22. Rosenberg OS, Deindl S, Sung RJ, Nairn AC, Kuriyan J. Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell. 2005 Dec 02; 123(5):849-60. PMID: 16325579.
      View in: PubMed
    23. Terlouw DJ, Nahlen BL, Courval JM, Kariuki SK, Rosenberg OS, Oloo AJ, Kolczak MS, Hawley WA, Lal AA, Kuile FO. Sulfadoxine-pyrimethamine in treatment of malaria in Western Kenya: increasing resistance and underdosing. Antimicrob Agents Chemother. 2003 Sep; 47(9):2929-32. PMID: 12936996.
      View in: PubMed
    24. Terlouw DJ, Courval JM, Kolczak MS, Rosenberg OS, Oloo AJ, Kager PA, Lal AA, Nahlen BL, ter Kuile FO. Treatment history and treatment dose are important determinants of sulfadoxine-pyrimethamine efficacy in children with uncomplicated malaria in Western Kenya. J Infect Dis. 2003 Feb 01; 187(3):467-76. PMID: 12552431.
      View in: PubMed
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