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Oren Rosenberg, MD, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone415-514-0412
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    Collapse Biography 
    Collapse Education and Training
    Yale University School of MedicineMD/PhD2007
    Brigham and Women's HospitalInternship and Residency2009Internal Medicine
    University of California, San FranciscoFellowship2013Internal Medicine, Division of Infectious Diseases

    Collapse Overview 
    Collapse Overview
    I am a physician-scientist who studies and treats infectious diseases. The goal of my laboratory is to discover and exploit molecular vulnerabilities in bacteria in order to design faster, cheaper, less toxic and more effective therapeutics to treat life-threatening infections.

    Collapse Research 
    Collapse Research Activities and Funding
    Clinical translation of D-amino acid derived PET tracers for imaging spinalinfection
    NIH/NIBIB R01EB024014Sep 20, 2017 - Jun 30, 2021
    Role: Co-Principal Investigator
    Protein secretion in bacterial pathogens
    NIH/NIAID R01AI128214May 8, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Structural and functional studies of M. tuberculosis type VII secretion
    NIH/NIAID K08AI091656Sep 16, 2011 - Aug 31, 2015
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nuclear imaging of bacterial infection- state of the art and future directions. J Nucl Med. 2020 Aug 06. Polvoy I, Flavell RR, Ohliger M, Rosenberg O, Wilson DM. PMID: 32764120.
      View in: PubMed   Mentions:    Fields:    
    2. Engineered ACE2 receptor traps potently neutralize SARS-CoV-2. bioRxiv. 2020 Aug 01. Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Lim SA, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Zhou XX, Hobman TC, Kortemme T, Wells JA. PMID: 32766586.
      View in: PubMed   Mentions:
    3. Small Molecule Sensors Targeting the Bacterial Cell Wall. ACS Infect Dis. 2020 07 10; 6(7):1587-1598. Parker MFL, Flavell RR, Luu JM, Rosenberg OS, Ohliger MA, Wilson DM. PMID: 32433879.
      View in: PubMed   Mentions:    Fields:    
    4. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 2020 07; 583(7816):459-468. Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. PMID: 32353859.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    5. Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms. J Labelled Comp Radiopharm. 2020 May 15; 63(5):231-239. Kalita M, Parker MFL, Luu JM, Stewart MN, Blecha JE, VanBrocklin HF, Evans MJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM. PMID: 32222086.
      View in: PubMed   Mentions:    Fields:    
    6. Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers. ACS Cent Sci. 2020 Feb 26; 6(2):155-165. Parker MFL, Luu JM, Schulte B, Huynh TL, Stewart MN, Sriram R, Yu MA, Jivan S, Turnbaugh PJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM. PMID: 32123733.
      View in: PubMed   Mentions:
    7. The structure of the endogenous ESX-3 secretion system. Elife. 2019 12 30; 8. Poweleit N, Czudnochowski N, Nakagawa R, Trinidad DD, Murphy KC, Sassetti CM, Rosenberg OS. PMID: 31886769.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    8. High Enantiomeric Excess In-Loop Synthesis of d-[methyl-11C]Methionine for Use as a Diagnostic Positron Emission Tomography Radiotracer in Bacterial Infection. ACS Infect Dis. 2020 01 10; 6(1):43-49. Stewart MN, Parker MFL, Jivan S, Luu JM, Huynh TL, Schulte B, Seo Y, Blecha JE, Villanueva-Meyer JE, Flavell RR, VanBrocklin HF, Ohliger MA, Rosenberg O, Wilson DM. PMID: 31697062.
      View in: PubMed   Mentions: 3     Fields:    
    9. Modulating Pathogenesis with Mobile-CRISPRi. J Bacteriol. 2019 11 15; 201(22). Qu J, Prasad NK, Yu MA, Chen S, Lyden A, Herrera N, Silvis MR, Crawford E, Looney MR, Peters JM, Rosenberg OS. PMID: 31481541.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    10. Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria. mBio. 2019 06 25; 10(3). Fay A, Czudnochowski N, Rock JM, Johnson JR, Krogan NJ, Rosenberg O, Glickman MS. PMID: 31239378.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    11. Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs. Nat Commun. 2019 05 09; 10(1):2127. Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T. PMID: 31073154.
      View in: PubMed   Mentions: 8     Fields:    
    12. Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi. Nat Microbiol. 2019 02; 4(2):244-250. Peters JM, Koo BM, Patino R, Heussler GE, Hearne CC, Qu J, Inclan YF, Hawkins JS, Lu CHS, Silvis MR, Harden MM, Osadnik H, Peters JE, Engel JN, Dutton RJ, Grossman AD, Gross CA, Rosenberg OS. PMID: 30617347.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    13. [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism. ACS Infect Dis. 2018 07 13; 4(7):1067-1072. Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM. PMID: 29712422.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    14. Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate. ACS Infect Dis. 2018 05 11; 4(5):797-805. Sriram R, Sun J, Villanueva-Meyer J, Mutch C, De Los Santos J, Peters J, Korenchan DE, Neumann K, Van Criekinge M, Kurhanewicz J, Rosenberg O, Wilson D, Ohliger MA. PMID: 29405697.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    15. Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers. Sci Rep. 2017 08 11; 7(1):7903. Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM. PMID: 28801560.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    16. Chlamydia interfere with an interaction between the mannose-6-phosphate receptor and sorting nexins to counteract host restriction. Elife. 2017 03 02; 6. Elwell CA, Czudnochowski N, von Dollen J, Johnson JR, Nakagawa R, Mirrashidi K, Krogan NJ, Engel JN, Rosenberg OS. PMID: 28252385.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    17. Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection. Cell Host Microbe. 2015 Jul 08; 18(1):109-21. Mirrashidi KM, Elwell CA, Verschueren E, Johnson JR, Frando A, Von Dollen J, Rosenberg O, Gulbahce N, Jang G, Johnson T, Jäger S, Gopalakrishnan AM, Sherry J, Dunn JD, Olive A, Penn B, Shales M, Cox JS, Starnbach MN, Derre I, Valdivia R, Krogan NJ, Engel J. PMID: 26118995.
      View in: PubMed   Mentions:
    18. Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell. 2015 Apr 23; 161(3):501-512. Rosenberg OS, Dovala D, Li X, Connolly L, Bendebury A, Finer-Moore J, Holton J, Cheng Y, Stroud RM, Cox JS. PMID: 25865481.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    19. Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10404-10. Lohse MB, Rosenberg OS, Cox JS, Stroud RM, Finer-Moore JS, Johnson AD. PMID: 24994900.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    20. First report of tenosynovitis in an immunocompetent person caused by Mycobacterium heraklionense. JMM Case Reports. 2014 Jun 1; 1(2). Malak Abedalthagafi, Oren Rosenberg, Steve Miller. .
      View in: Publisher Site   Mentions:
    21. The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing. RNA. 2014 May; 20(5):656-69. Hadjivassiliou H, Rosenberg OS, Guthrie C. PMID: 24681967.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    22. Molecular Determinants of Substrate Specificity in Type VII Secretion Systems. Biophysical Journal. 2014 Jan 1; 106(2):474a. Dustin Dovala, Oren S. Rosenberg, Jeffery S. Cox. .
      View in: Publisher Site   Mentions:
    23. Immune reconstitution reactions in human immunodeficiency virus-negative patients: report of a case and review of the literature. JAMA Dermatol. 2013 Jan; 149(1):74-8. Scharschmidt TC, Amerson EH, Rosenberg OS, Jacobs RA, McCalmont TH, Shinkai K. PMID: 23324760.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    24. A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme. Cell. 2011 Oct 1; 147(3):704. Luke H. Chao, Margaret M. Stratton, Il-Hyung Lee, Oren S. Rosenberg, Joshua Levitz, Daniel J. Mandell, Tanja Kortemme, Jay T. Groves, Howard Schulman, John Kuriyan. .
      View in: Publisher Site   Mentions:
    25. A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell. 2011 Sep 02; 146(5):732-45. Chao LH, Stratton MM, Lee IH, Rosenberg OS, Levitz J, Mandell DJ, Kortemme T, Groves JT, Schulman H, Kuriyan J. PMID: 21884935.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    26. EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13450-5. Rosenberg OS, Dovey C, Tempesta M, Robbins RA, Finer-Moore JS, Stroud RM, Cox JS. PMID: 21795602.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    27. Oligomerization states of the association domain and the holoenyzme of Ca2+/CaM kinase II. FEBS J. 2006 Feb; 273(4):682-94. Rosenberg OS, Deindl S, Comolli LR, Hoelz A, Downing KH, Nairn AC, Kuriyan J. PMID: 16441656.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    28. Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell. 2005 Dec 02; 123(5):849-60. Rosenberg OS, Deindl S, Sung RJ, Nairn AC, Kuriyan J. PMID: 16325579.
      View in: PubMed   Mentions: 112     Fields:    Translation:AnimalsCells
    29. Sulfadoxine-pyrimethamine in treatment of malaria in Western Kenya: increasing resistance and underdosing. Antimicrob Agents Chemother. 2003 Sep; 47(9):2929-32. Terlouw DJ, Nahlen BL, Courval JM, Kariuki SK, Rosenberg OS, Oloo AJ, Kolczak MS, Hawley WA, Lal AA, Kuile FO. PMID: 12936996.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    30. Treatment history and treatment dose are important determinants of sulfadoxine-pyrimethamine efficacy in children with uncomplicated malaria in Western Kenya. J Infect Dis. 2003 Feb 01; 187(3):467-76. Terlouw DJ, Courval JM, Kolczak MS, Rosenberg OS, Oloo AJ, Kager PA, Lal AA, Nahlen BL, ter Kuile FO. PMID: 12552431.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
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