The regulation of gene expression in eukaryotes is my major interest. Chromatin structure, epigenetic marks, context-dependent signaling, and the scrum of transcription factor binding throughout the genome all contribute to the expression of a gene. I collaborate with other researchers to study the regulation of gene expression in a number of contexts from embryonic development, to stem cell differentiation, to cross-species comparisons of regulatory architecture.
I also specialize generally in computational biology approaches to understanding and analyzing enormous biological datasets.
As a professional consultant with Gladstone Institutes and UCSF's CTSI, I have a number of ongoing research projects across a range of subjects and am available for consultations with new researchers.