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Tyler Detomasi, PhD

Title(s)Postdoctoral Scholar, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address600 16th Street, #S514
San Francisco CA 94158
PronounsHe/Him/His
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Discovery of Coronavirus Main Protease Inhibitors with Enhanced Brain Exposure and Potent Oral Efficacy in SARS-CoV-2 and MERS Infection Models. J Med Chem. 2026 Jan 05. Lizzadro L, Li J, Taha TY, Degotte G, Detomasi TC, Zapatero-Belinchon FJ, Hantz ER, Huang S, Matsui Y, Henderson WR, McCann JT, Montano M, Rosecrans J, Torres Pomares DF, McGovern BL, Diaz-Tapia R, Benjamin J, Gordon ME, Suazo ID, Settineri NS, Diallo A, Krogan NJ, Shoichet BK, Verba KA, Albrecht R, García-Sastre A, White KM, Ott M, Craik CS, Renslo AR. PMID: 41490206.
      View in: PubMed   Mentions:
    2. Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus MPro inhibitors with potent in vivo efficacy. Sci Adv. 2025 04 25; 11(17):eadt7836. Detomasi TC, Degotte G, Huang S, Suryawanshi RK, Diallo A, Lizzadro L, Zapatero-Belinchón FJ, Taha TY, Li J, Richards AL, Hantz ER, Alam Z, Montano M, McCavitt-Malvido M, Gumpena R, Partridge JR, Correy GJ, Matsui Y, Charvat AF, Glenn IS, Rosecrans J, Revalde JL, Anderson D, Hultquist JF, Arkin MR, Neitz RJ, Swaney DL, Krogan NJ, Shoichet BK, Verba KA, Ott M, Renslo AR, Craik CS. PMID: 40267184; PMCID: PMC12017303.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins. Science. 2025 Mar 28; 387(6741):eadq8331. Jain A, Heremans I, Rademaker G, Detomasi TC, Rohweder P, Anderson D, Zhang J, Hernandez GA, Gupta S, von Linde T, Lange M, Spacci M, Luo J, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, Zoncu R. PMID: 40146846.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Leucine Aminopeptidase LyLAP enables lysosomal degradation of membrane proteins. bioRxiv. 2024 Dec 14. Jain A, Heremans I, Rademaker G, Detomasi TC, Hernandez GA, Zhang J, Gupta S, von Linde T, Lange M, Spacci M, Rohweder P, Anderson D, Citron YR, Olzmann JA, Dawson DW, Craik CS, Bommer G, Perera RM, Zoncu R. PMID: 39713462; PMCID: PMC11661280.
      View in: PubMed   Mentions:
    5. Proteases influence colony aggregation behavior in Vibrio cholerae. J Biol Chem. 2023 12; 299(12):105386. Detomasi TC, Batka AE, Valastyan JS, Hydorn MA, Craik CS, Bassler BL, Marletta MA. PMID: 37898401; PMCID: PMC10709122.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors. Protein Sci. 2023 08; 32(8):e4712. Fink EA, Bardine C, Gahbauer S, Singh I, Detomasi TC, White K, Gu S, Wan X, Chen J, Ary B, Glenn I, O'Connell J, O'Donnell H, Fajtová P, Lyu J, Vigneron S, Young NJ, Kondratov IS, Alisoltani A, Simons LM, Lorenzo-Redondo R, Ozer EA, Hultquist JF, O'Donoghue AJ, Moroz YS, Taunton J, Renslo AR, Irwin JJ, García-Sastre A, Shoichet BK, Craik CS. PMID: 37354015; PMCID: PMC10364469.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsPHPublic Health
    7. A Prototype Assay Multiplexing SARS-CoV-2 3CL-Protease and Angiotensin-Converting Enzyme 2 for Saliva-Based Diagnostics in COVID-19. Biosensors (Basel). 2023 Jun 27; 13(7). Suresh V, Sheik DA, Detomasi TC, Zhao T, Zepeda T, Saladi S, Rajesh UC, Byers K, Craik CS, Davisson VJ. PMID: 37504081; PMCID: PMC10377347.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Characterization of a unique polysaccharide monooxygenase from the plant pathogen Magnaporthe oryzae. Proc Natl Acad Sci U S A. 2023 02 21; 120(8):e2215426120. Martinez-D'Alto A, Yan X, Detomasi TC, Sayler RI, Thomas WC, Talbot NJ, Marletta MA. PMID: 36791100; PMCID: PMC9974505.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    9. A moonlighting function of a chitin polysaccharide monooxygenase, CWR-1, in Neurospora crassa allorecognition. Elife. 2022 08 30; 11. Detomasi TC, Rico-Ramírez AM, Sayler RI, Gonçalves AP, Marletta MA, Glass NL. PMID: 36040303; PMCID: PMC9550227.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    10. A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells. Chem Sci. 2020 Dec 15; 12(5):1720-1729. Wang Z, Detomasi TC, Chang CJ. PMID: 34163931; PMCID: PMC8179100.
      View in: PubMed   Mentions: 11  
    11. Substrate selectivity in starch polysaccharide monooxygenases. J Biol Chem. 2019 08 09; 294(32):12157-12166. Vu VV, Hangasky JA, Detomasi TC, Henry SJW, Ngo ST, Span EA, Marletta MA. PMID: 31235519; PMCID: PMC6690692.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    12. A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals. J Am Chem Soc. 2018 10 24; 140(42):13764-13774. Su TA, Shihadih DS, Cao W, Detomasi TC, Heffern MC, Jia S, Stahl A, Chang CJ. PMID: 30351140; PMCID: PMC6465169.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
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