Jody Baron, MD, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-476-5728
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    Collapse Research 
    Collapse Research Activities and Funding
    Identifying and modulating therapeutic targets in a model of hepatitis B
    NIH R01AI139762Aug 16, 2018 - Jul 31, 2022
    Role: Principal Investigator
    Clinical & Immunological Study of Treatment Withdrawal in E-Ag Negative Hepatitis B
    NIH R01DK103735Sep 1, 2016 - Jun 30, 2026
    Role: Co-Principal Investigator
    Identifying and modulating therapeutic targets in a model of hepatitis B
    NIH R56DK093646Aug 24, 2012 - Aug 31, 2018
    Role: Principal Investigator
    Identifying and modulating therapeutic targets in a model of hepatitis B
    NIH R01DK093646Aug 24, 2012 - Sep 19, 2017
    Role: Principal Investigator
    Age-dependent immune responses to hepatitis B: a mouse model of human disease
    NIH R56AI091872Sep 6, 2011 - Aug 31, 2013
    Role: Principal Investigator
    Understanding Immunopathogenesis of Hepatitis B Virus
    NIH R01AI068090Mar 1, 2006 - Feb 28, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8. Sci Immunol. 2021 Mar 26; 6(57). Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL. PMID: 33771888.
      View in: PubMed   Mentions:    Fields:    
    2. Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β. Cell. 2020 02 06; 180(3):490-501.e16. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL. PMID: 31955848.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    3. Structural Studies avß8 Integrin by Single Particle Cryo-EM. Microscopy and Microanalysis. 2019 Aug 1; 25(S2):1312-1313. Campbell CM, Cormier CA, Ito IS, Wu WS, Lou LJ, Marks MJ, Baron BJ, Nishimura NS, Cheng CY. .
      View in: Publisher Site   Mentions:
    4. Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells. JCI Insight. 2018 10 18; 3(20). Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL. PMID: 30333313.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    5. Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension. Nat Struct Mol Biol. 2018 08; 25(8):698-704. Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y. PMID: 30061598.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    6. An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Sci Transl Med. 2018 03 21; 10(433). Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL. PMID: 29563320.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    7. CD18 deficiency improves liver injury in the MCD model of steatohepatitis. PLoS One. 2017; 12(9):e0183912. Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ. PMID: 28873429.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice. Cell Mol Gastroenterol Hepatol. 2017 Sep; 4(2):223-236. Duwaerts CC, Amin AM, Siao K, Her C, Fitch M, Beysen C, Turner SM, Goodsell A, Baron JL, Grenert JP, Cho SJ, Maher JJ. PMID: 28649594.
      View in: PubMed   Mentions: 5     Fields:    
    9. Role of IL-17A in murine models of COPD airway disease. . 2017 01 01; 312(1):L122-L130. Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura SL. PMID: 27913421.
      View in: PubMed   Mentions:
    10. Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man. Hepatology. 2016 Jan; 63(1):260. Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL. PMID: 26457468.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    11. TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 01; 195(3):1182-90. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL. PMID: 26109638.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    12. Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter. J Biol Chem. 2015 Jun 05; 290(23):14717-28. Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL. PMID: 25918170.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    13. A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease. J Immunol. 2015 Apr 15; 194(8):3962-9. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL. PMID: 25786688.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    14. Selective targeting of TGF-β activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. PMID: 24944194.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimals
    15. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice. PLoS One. 2013; 8(10):e77255. Fomin ME, Zhou Y, Beyer AI, Publicover J, Baron JL, Muench MO. PMID: 24167566.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    16. S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus. Cytokine. 2013 Sep 1; 63(3):241. Publicover PJ, Gaggar GA, Nishimura NS, Van Horn VC, Goodsell GA, Muench MM, Reinhardt RR, van Rooijen vN, Peters PA, Cyster CJ, Erle ED, Rosenthal RP, Avanesyan AL, Spolski SR, Leonard LW, Cooper CS, Baron BJ. .
      View in: Publisher Site   Mentions:
    17. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep; 123(9):3728-39. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. PMID: 23925290.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    18. Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity. Nat Med. 2012 Jul; 18(7):1060-8. Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS. PMID: 22706385.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimalsCells
    19. 742 Hepatitis B Virus Infection Leads to Alterations in the Repertoire of Self Lipid Antigens Presented by Hepatocytes and is Associated With Direct and Indirect Activation of Natural Killer T Cells. Gastroenterology. 2012 May 1; 142(5):s-927. Zeissig ZS, Murata MK, Sweet SL, Publicover PJ, Hu HZ, Kaser KA, Arlt AA, Günther GR, Hampe HJ, Schreiber SS, Baron BJ, Moody MD, Liang LT, Blumberg BR. .
      View in: Publisher Site   Mentions:
    20. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β. J Clin Invest. 2011 Jul; 121(7):2863-75. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL. PMID: 21646718.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    21. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest. 2011 Mar; 121(3):1154-62. Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL. PMID: 21393863.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    22. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18187-92. Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. PMID: 17991774.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    23. Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. J Exp Med. 2003 Oct 06; 198(7):1069-76. Stetson DB, Mohrs M, Reinhardt RL, Baron JL, Wang ZE, Gapin L, Kronenberg M, Locksley RM. PMID: 14530376.
      View in: PubMed   Mentions: 247     Fields:    Translation:AnimalsCells
    24. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8395-400. Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, Locksley RM, Kronenberg M. PMID: 12829795.
      View in: PubMed   Mentions: 92     Fields:    Translation:AnimalsCells
    25. The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol. 2002 Apr 29; 157(3):493-507. Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL. PMID: 11970960.
      View in: PubMed   Mentions: 295     Fields:    Translation:HumansAnimalsCells
    26. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity. 2002 Apr; 16(4):583-94. Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. PMID: 11970881.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    27. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11521-6. Cerwenka A, Baron JL, Lanier LL. PMID: 11562472.
      View in: PubMed   Mentions: 179     Fields:    Translation:AnimalsCells
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