William Temple, MD

Title(s)Clinical Fellow, Pediatrics
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    UC Los Angeles, Los Angeles, CAB.S.06/2011Microbiology, Immunology, and Molecular Genetics
    UC San Francisco, San Francisco, CAM.D.05/2016Medicine
    UC San Francisco, San Francisco, CA06/2019Pediatrics Residency
    UC San Francisco, San Francisco, CA07/2022Clinical Fellow, Pediatric Hematology & Oncology
    UC San Francisco, San Francisco, CA06/2023Postdoctoral Scholar, Cancer Immunotherapy
    UC San Francisco, San Francisco, CA07/2024Advanced Fellow, Pediatric Blood & Marrow Transplantation and Immunotherapy
    Collapse Awards and Honors
    University of California, Los Angeles2009  - 2011Howard Hughes Medical Institute Undergraduate Research Scholarship
    University of California, Los Angeles  - 2011Magna Cum Laude Graduate
    University of California, Los Angeles  - 2011Phi Beta Kappa
    University of California, Los Angeles  - 2011Undergraduate Research Week Honoree
    University of California, San Francisco2012  - 2016Alpha Omega Alpha Honor Medical Society
    University of California, San Francisco2017  - 20182018 House Staff Teaching Award, Honorable Mention, UCSF Pediatrics Residency
    University of California, San Francisco2016  - 2019Clinical and Translational Research Pathway, UCSF Pediatrics Residency Program
    University of California, San Francisco  - 2020Employee of the Month – UCSF Benioff Children’s Hospital Hematology/Oncology Unit
    University of California, San Francisco2020  - 2023Chan Zuckerberg Biohub Physician-Scientist Fellowship Program Fellow
    Chan Zuckerberg Biohub2020  - 2023Physician-Scientist Fellowship Program Fellow
    American Society of Hematology2022  - 2023Research Training Award for Fellows
    International Society of Cell & Gene Therapy and American Society of Transplantation & Cell Therapy  - 2023Cell Therapy Training Course Scholar at University of Pennsylvania
    American Society of Hematology2023  - 2024Clinical Research Training Institute Scholar
    American Society of Transplantation and Cellular Therapy2024  - 2026New Investigator Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    First-in-human phase 1 clinical trial evaluating CD72 nanoCARs for pediatric and young adult patients with relapsed/refractory B cell malignancies
    American Society of Transplantation and Cellular Therapy "New Investigator Award" Jul 1, 2024 - Jun 30, 2026
    Role: Principal Investigator
    CD72 nanoCARs for treatment of relapsed/refractory B cell malignancies
    American Society of Hematology - Research Training Award for Fellows Jul 1, 2022 - Jun 30, 2023
    CD72 Nanobody-based CAR-T cells for relapsed/refractory B cell malignancies
    Chan Zuckerberg Biohub Physician-Scientist Fellowship Program Jul 1, 2020 - Jun 30, 2023
    CD72 Nanobody-based CAR-T cells for relapsed/refractory B cell malignancies
    NIH T32 - Research Training in Childhood Cancer Jul 1, 2020 - Jun 30, 2022
    Role: Trainee on the grant

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transplantation & Cellular Therapy Meetings of ASTCT and CIBMTR. Preclinical Development and Characterization of Humanized Anti-CD72 Nanobody Chimeric Antigen Receptor T Cells for B Cell Malignancies. 2024. William C. Temple, Adila Izgutdina, Matthew A. Nix, Benjamin J. Huang, Paul Phojanakong, Juan Antonio Camara Serrano, Fernando Salangsang, Veronica Steri, Simayijiang Xirenayi, Elliot Stieglitz, Arun P. Wiita . View Publication.
    2. American Society of Hematology. San Diego, CA. December 2023. Affinity Matured CD72 NanoCAR-T Improves Efficacy Versus Low Antigen Density B-Cell Non-Hodgkin Lymphoma Models. 2023. Izgutdina A, Temple WC, Nix MA, Geng H, Ramos E, Naik A, Larson R, Salangsang F, Phojanakong P, Serrano JAC, Zakraoui O, Tariq I, Maus MV, Steri V, Wiita AP. .
    3. Framework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies. J Immunother Cancer. 2023 11 24; 11(11). Temple WC, Nix MA, Naik A, Izgutdina A, Huang BJ, Wicaksono G, Phojanakong P, Serrano JAC, Young EP, Ramos E, Salangsang F, Steri V, Xirenayi S, Hermiston M, Logan AC, Stieglitz E, Wiita AP. PMID: 38007238; PMCID: PMC10680002.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Pre-and post-HSCT use of TKI therapy for fusion-driven B-ALL: A case series of five pediatric, adolescent and young adult patients. Cancer Rep (Hoboken). 2023 Dec; 6(12):e1901. Shumock SS, Temple WC, Marinoff A, Aaronson K, Southworth E, Xirenayi S, Lee AG, Leung SG, Sweet-Cordero EA, Hermiston M, Higham C, Stieglitz E. PMID: 37933765; PMCID: PMC10728537.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target. Nat Cancer. 2023 Nov; 4(11):1592-1609. Mandal K, Wicaksono G, Yu C, Adams JJ, Hoopmann MR, Temple WC, Izgutdina A, Escobar BP, Gorelik M, Ihling CH, Nix MA, Naik A, Xie WH, Hübner J, Rollins LA, Reid SM, Ramos E, Kasap C, Steri V, Serrano JAC, Salangsang F, Phojanakong P, McMillan M, Gavallos V, Leavitt AD, Logan AC, Rooney CM, Eyquem J, Sinz A, Huang BJ, Stieglitz E, Smith CC, Moritz RL, Sidhu SS, Huang L, Wiita AP. PMID: 37904046; PMCID: PMC10663162.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    6. Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults. Best Pract Res Clin Haematol. 2023 03; 36(1):101449. Temple WC, Mueller S, Hermiston ML, Burkhardt B. PMID: 36907639.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Blood. Humanized Nanobody Anti-CD72 CAR-T Cells Efficiently Eliminate B-Cell Malignancies Via Improved Affinity for CD72 but Induce Persistent Antigen Downregulation In Vivo. 2022. William C Temple, Gianina Wicaksono, Akul Naik, Adila Izgutdina, Matthew A Nix, Elizabeth Young, Paul Phojanakong, Juan Antonio Camara Serrano, Veronica Steri, Fernando Salangsang, Arun P Wiita. View Publication.
    8. Blood. Structural Surfaceomics Reveals an AML-Specific Conformation of Integrin-β2 As an Immunotherapeutic Target. 2022. Kamal Mandal, Gianina Wicaksono, Clinton Yu, Jarrett J Adams, Michael R Hoopmann, William C Temple, Bonell Patino Escobar, Maryna Gorelik, Christian Ihling, Matthew A Nix, Akul Naik, Emilio Ramos, Corynn Kasap, Veronica Steri, Juan Antonio Camara Serrano, Fernando Salangsang, Paul Phojanakong, Melanie McMillan, Victor Gavallos, Andrew D Leavitt, Andrea Sinz, Benjamin J. Huang, Elliot Stieglitz, Catherine Smith, Robert L Moritz, Sachdeva S Sidhu, Lan Huang, Arun P Wiita. View Publication.
    9. Leukemia Research. CD72 nanobody CAR-T cells have potent antitumor efficacy in B cell malignancies. 2022; 121:S8. W. Temple, M. Nix, G. Wicaksono, D. Wang, P. Phojanakong, V. Steri, B. Hann, M. Hermiston, A. Wiita. View Publication.
    10. Incorporating Radiomics into Machine Learning Models to Predict Outcomes of Neuroblastoma. J Digit Imaging. 2022 06; 35(3):605-612. Liu G, Poon M, Zapala MA, Temple WC, Vo KT, Matthay KK, Mitra D, Seo Y. PMID: 35237892; PMCID: PMC9156639.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    11. Blood. CD72 Nanobody-Based CAR-T Cells Have Potent Anti-Tumor Efficacy in B Cell Malignancies. 2021; (138 (Suppl):1717. Matthew A Nix, William C Temple, William Karlon, Donghui Wang, Paul Phojanakong, Veronica Steri, Byron Hann, Arun P Wiita. View Publication.
    12. Association of image-defined risk factors with clinical features, histopathology, and outcomes in neuroblastoma. Cancer Med. 2021 04; 10(7):2232-2241. Temple WC, Vo KT, Matthay KK, Balliu B, Coleman C, Michlitsch J, Phelps A, Behr S, Zapala MA. PMID: 33314708; PMCID: PMC7982630.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    13. Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring. Front Genet. 2018; 9:642. Martin LJ, Meng Q, Blencowe M, Lagarrigue S, Xiao S, Pan C, Wier J, Temple WC, Devaskar SU, Lusis AJ, Yang X. PMID: 30619467; PMCID: PMC6297185.
      View in: PubMed   Mentions: 6  
    14. Advances in Neuroblastoma Research Conference. San Francisco, California. Association of image-defined risk factors with clinical features, histopathology, and outcomes in neuroblastoma. 2018. Temple WC, Vo KT, Matthay KK, Abadi C, Michlitsch J, Phelps A, Behr S, Zapala MA. View Publication.
    15. Erratum to: Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group. Eur J Nucl Med Mol Imaging. 2016 Jul; 43(7):1396. Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Parisi MT, Shulkin BL, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG. PMID: 27044383.
      View in: PubMed   Mentions:    Fields:    
    16. Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group. Eur J Nucl Med Mol Imaging. 2016 Mar; 43(3):474-481. Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG. PMID: 26338179; PMCID: PMC4733400.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    17. ASCO Annual Meeting. Vesicular monoamine transporter protein expression in neuroblastoma: A report from the Children’s Oncology Group. Journal of Clinical Oncology, 2015 ASCO Annual Meeting (May 29 - June 2, 2015). Vol 33, No 15_suppl (May 20 Supplement), 2015: 10043. 2015. DuBois SG, Temple W, Mendelsohn L, Kim G, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Ryn VC, Yanik GA, Kreissman SG, Hogarty M, Matthay KK. View Publication.
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