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T cell receptor precision editing of regulatory T cells for celiac disease. Sci Transl Med. 2025 Mar 19; 17(790):eadr8941.
Porret R, Alcaraz-Serna A, Peter B, Bernier-Latmani J, Cecchin R, Alfageme-Abello O, Ermellino L, Hafezi M, Pace E, du Pré MF, Lana E, Golshayan D, Velin D, Eyquem J, Tang Q, Petrova TV, Coukos G, Irving M, Pot C, Pantaleo G, Sollid LM, Muller YD. PMID: 40106579.
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SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy. J Immunol. 2025 Mar 09.
Millan AJ, Allain V, Nayak I, Libang JB, Quijada-Madrid LM, Arakawa-Hoyt JS, Ureno G, Rothrock AG, Shemesh A, Aguilar OA, Eyquem J, Das J, Lanier LL. PMID: 40073103; PMCID: PMC11952873.
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Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells. Nat Protoc. 2025 Mar 03.
Sahu SU, Castro M, Muldoon JJ, Asija K, Wyman SK, Krishnappa N, de Oñate L, Eyquem J, Nguyen DN, Wilson RC. PMID: 40032999.
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Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells. Sci Rep. 2025 Feb 17; 15(1):5749.
Sytsma BJ, Allain V, Bourke S, Faizee F, Fathi M, Ferreira LMR, Brewer WJ, Li L, Pan FL, Rothrock AG, Nyberg WA, Li Z, Wilson LH, Berdeaux R, Eyquem J, Pawell RS. PMID: 39962112; PMCID: PMC11832915.
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1 Fields:
Translation:
HumansCells
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SEED-Selection enables high-efficiency enrichment of primary T cells edited at multiple loci. Nat Biotechnol. 2025 Feb 05.
Chang CR, Vykunta VS, Lee JHJ, Li K, Kochendoerfer C, Muldoon JJ, Wang CH, Mazumder T, Sun Y, Goodman DB, Nyberg WA, Liu C, Allain V, Rothrock A, Ye CJ, Marson A, Shy BR, Eyquem J. PMID: 39910194.
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In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313. Immunity. 2025 Feb 11; 58(2):499-512.e7.
Nyberg WA, Wang CH, Ark J, Liu C, Clouden S, Qualls A, Caryotakis S, Wells E, Simon K, Garza C, Bernard PL, Lopez-Ichikawa M, Li Z, Seo J, Kimmerly GR, Muldoon JJ, Chen PA, Li M, Liang HE, Kersten K, Rosales A, Kuhn N, Ye CJ, Gardner JM, Molofsky A, Ricardo-Gonzalez RR, Asokan A, Eyquem J. PMID: 39909036.
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HumansAnimalsCells
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Author Correction: Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells. Nat Biomed Eng. 2024 Nov; 8(11):1500.
van der Stegen SJC, Lindenbergh PL, Petrovic RM, Xie H, Diop MP, Alexeeva V, Shi Y, Mansilla-Soto J, Hamieh M, Eyquem J, Cabriolu A, Wang X, Abujarour R, Lee T, Clarke R, Valamehr B, Themeli M, Riviere I, Sadelain M. PMID: 38347164.
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PubMed Mentions:
1 Fields:
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Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells. Res Sq. 2024 Sep 19.
Sytsma BJ, Allain V, Bourke S, Faizee F, Fathi M, Berdeaux R, Ferreira LMR, Brewer WJ, Li L, Pan FL, Rothrock AG, Nyberg WA, Li Z, Wilson LH, Eyquem J, Pawell RS. PMID: 39372944; PMCID: PMC11451650.
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An improved approach to generate IL-15+/+/TGFβR2-/- iPSC-derived natural killer cells using TALEN. Cell Rep Methods. 2024 Sep 16; 4(9):100857.
Chen AP, Gao P, Lin L, Ashok P, He H, Ma C, Zou DL, Allain V, Boyne A, Juillerat A, Duchateau P, Rath A, Teper D, Arulanandam A, Chang HM, Eyquem J, Li W. PMID: 39260365; PMCID: PMC11440057.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells. bioRxiv. 2024 Aug 19.
Sahu S, Castro M, Muldoon JJ, Asija K, Wyman SK, Krishnappa N, de Onate L, Eyquem J, Nguyen DN, Wilson RC. PMID: 39071446; PMCID: PMC11275745.
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Localized in vivo gene editing of murine cancer-associated fibroblasts. bioRxiv. 2024 Jul 16.
Kuhn NF, Zaleta-Linares I, Nyberg WA, Eyquem J, Krummel MF. PMID: 39071432; PMCID: PMC11275728.
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Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells. bioRxiv. 2024 Jul 13.
Sytsma BJ, Allain V, Bourke S, Faizee F, Fathi M, Berdeaux R, Ferreira LMR, Brewer WJ, Li L, Pan FL, Rothrock AG, Nyberg WA, Li Z, Wilson LH, Eyquem J, Pawell RS. PMID: 38979201; PMCID: PMC11230359.
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Spleen Tyrosine Kinase (SYK) negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy. bioRxiv. 2024 Jul 13.
Millan AJ, Allain V, Nayak I, Aguilar OA, Arakawa-Hoyt JS, Ureno G, Rothrock AG, Shemesh A, Eyquem J, Das J, Lanier LL. PMID: 39026749; PMCID: PMC11257556.
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Ultra-high efficiency T cell reprogramming at multiple loci with SEED-Selection. bioRxiv. 2024 Feb 07.
Chang CR, Vykunta VS, Goodman DB, Muldoon JJ, Nyberg WA, Liu C, Allain V, Rothrock A, Wang CH, Marson A, Shy BR, Eyquem J. PMID: 38370809; PMCID: PMC10871224.
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Base-editing mutagenesis maps alleles to tune human T cell functions. Nature. 2024 Jan; 625(7996):805-812.
Schmidt R, Ward CC, Dajani R, Armour-Garb Z, Ota M, Allain V, Hernandez R, Layeghi M, Xing G, Goudy L, Dorovskyi D, Wang C, Chen YY, Ye CJ, Shy BR, Gilbert LA, Eyquem J, Pritchard JK, Dodgson SE, Marson A. PMID: 38093011; PMCID: PMC11065414.
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22 Fields:
Translation:
HumansCells
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Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target. Nat Cancer. 2023 11; 4(11):1592-1609.
Mandal K, Wicaksono G, Yu C, Adams JJ, Hoopmann MR, Temple WC, Izgutdina A, Escobar BP, Gorelik M, Ihling CH, Nix MA, Naik A, Xie WH, Hübner J, Rollins LA, Reid SM, Ramos E, Kasap C, Steri V, Serrano JAC, Salangsang F, Phojanakong P, McMillan M, Gavallos V, Leavitt AD, Logan AC, Rooney CM, Eyquem J, Sinz A, Huang BJ, Stieglitz E, Smith CC, Moritz RL, Sidhu SS, Huang L, Wiita AP. PMID: 37904046; PMCID: PMC10663162.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells. Cell. 2023 10 12; 186(21):4567-4582.e20.
Tsuchida CA, Brandes N, Bueno R, Trinidad M, Mazumder T, Yu B, Hwang B, Chang C, Liu J, Sun Y, Hopkins CR, Parker KR, Qi Y, Hofman L, Satpathy AT, Stadtmauer EA, Cate JHD, Eyquem J, Fraietta JA, June CH, Chang HY, Ye CJ, Doudna JA. PMID: 37794590; PMCID: PMC10664023.
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PubMed Mentions:
58 Fields:
Translation:
HumansCells
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Modular pooled discovery of synthetic knockin sequences to program durable cell therapies. Cell. 2023 09 14; 186(19):4216-4234.e33.
Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A. PMID: 37714135; PMCID: PMC10508323.
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19 Fields:
Translation:
Humans
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Novel extragenic genomic safe harbors for precise therapeutic T-cell engineering. Blood. 2023 06 01; 141(22):2698-2712.
Odak A, Yuan H, Feucht J, Cantu VA, Mansilla-Soto J, Kogel F, Eyquem J, Everett J, Bushman FD, Leslie CS, Sadelain M. PMID: 36745870; PMCID: PMC10273162.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes. Nat Biomed Eng. 2023 05; 7(5):647-660.
Foss DV, Muldoon JJ, Nguyen DN, Carr D, Sahu SU, Hunsinger JM, Wyman SK, Krishnappa N, Mendonsa R, Schanzer EV, Shy BR, Vykunta VS, Allain V, Li Z, Marson A, Eyquem J, Wilson RC. PMID: 37147433; PMCID: PMC10129304.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells. bioRxiv. 2023 Mar 22.
Tsuchida CA, Brandes N, Bueno R, Trinidad M, Mazumder T, Yu B, Hwang B, Chang C, Liu J, Sun Y, Hopkins CR, Parker KR, Qi Y, Satpathy AT, Stadtmauer EA, Cate JHD, Eyquem J, Fraietta JA, June CH, Chang HY, Ye CJ, Doudna JA. PMID: 36993359; PMCID: PMC10055432.
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An evolved AAV variant enables efficient genetic engineering of murine T cells. Cell. 2023 01 19; 186(2):446-460.e19.
Nyberg WA, Ark J, To A, Clouden S, Reeder G, Muldoon JJ, Chung JY, Xie WH, Allain V, Steinhart Z, Chang C, Talbot A, Kim S, Rosales A, Havlik LP, Pimentel H, Asokan A, Eyquem J. PMID: 36638795; PMCID: PMC10540678.
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27 Fields:
Translation:
AnimalsCells
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Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies. Sci Transl Med. 2022 11 09; 14(670):eabm1463.
Goodman DB, Azimi CS, Kearns K, Talbot A, Garakani K, Garcia J, Patel N, Hwang B, Lee D, Park E, Vykunta VS, Shy BR, Ye CJ, Eyquem J, Marson A, Bluestone JA, Roybal KT. PMID: 36350984; PMCID: PMC9939256.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Nat Immunol. 2022 10; 23(10):1424-1432.
Witkowski MT, Lee S, Wang E, Lee AK, Talbot A, Ma C, Tsopoulidis N, Brumbaugh J, Zhao Y, Roberts KG, Hogg SJ, Nomikou S, Ghebrechristos YE, Thandapani P, Mullighan CG, Hochedlinger K, Chen W, Abdel-Wahab O, Eyquem J, Aifantis I. PMID: 36138187; PMCID: PMC9611506.
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16 Fields:
Translation:
HumansCells
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High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails. Nat Biotechnol. 2023 04; 41(4):521-531.
Shy BR, Vykunta VS, Ha A, Talbot A, Roth TL, Nguyen DN, Pfeifer WG, Chen YY, Blaeschke F, Shifrut E, Vedova S, Mamedov MR, Chung JJ, Li H, Yu R, Wu D, Wolf J, Martin TG, Castro CE, Ye L, Esensten JH, Eyquem J, Marson A. PMID: 36008610; PMCID: PMC10065198.
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PubMed Mentions:
75 Fields:
Translation:
HumansCells
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RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature. 2022 09; 609(7925):174-182.
Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A. PMID: 36002574; PMCID: PMC9433322.
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PubMed Mentions:
71 Fields:
Translation:
HumansAnimalsCells
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Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells. Nat Biomed Eng. 2022 11; 6(11):1284-1297.
van der Stegen SJC, Lindenbergh PL, Petrovic RM, Xie H, Diop MP, Alexeeva V, Shi Y, Mansilla-Soto J, Hamieh M, Eyquem J, Cabriolu A, Wang X, Abujarour R, Lee T, Clarke R, Valamehr B, Themeli M, Riviere I, Sadelain M. PMID: 35941192; PMCID: PMC9669107.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance. Nat Commun. 2022 07 15; 13(1):4121.
Ferguson ID, Patiño-Escobar B, Tuomivaara ST, Lin YT, Nix MA, Leung KK, Kasap C, Ramos E, Nieves Vasquez W, Talbot A, Hale M, Naik A, Kishishita A, Choudhry P, Lopez-Girona A, Miao W, Wong SW, Wolf JL, Martin TG, Shah N, Vandenberg S, Prakash S, Besse L, Driessen C, Posey AD, Mullins RD, Eyquem J, Wells JA, Wiita AP. PMID: 35840578; PMCID: PMC9287322.
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PubMed Mentions:
45 Fields:
Translation:
Humans
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HLA-independent T cell receptors for targeting tumors with low antigen density. Nat Med. 2022 02; 28(2):345-352.
Mansilla-Soto J, Eyquem J, Haubner S, Hamieh M, Feucht J, Paillon N, Zucchetti AE, Li Z, Sjöstrand M, Lindenbergh PL, Saetersmoen M, Dobrin A, Maurin M, Iyer A, Garcia Angus A, Miele MM, Zhao Z, Giavridis T, van der Stegen SJC, Tamzalit F, Rivière I, Huse M, Hendrickson RC, Hivroz C, Sadelain M. PMID: 35027758; PMCID: PMC9469647.
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PubMed Mentions:
80 Fields:
Translation:
HumansAnimals
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The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28. Front Immunol. 2021; 12:639818.
Muller YD, Nguyen DP, Ferreira LMR, Ho P, Raffin C, Valencia RVB, Congrave-Wilson Z, Roth TL, Eyquem J, Van Gool F, Marson A, Perez L, Wells JA, Bluestone JA, Tang Q. PMID: 33833759; PMCID: PMC8021955.
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PubMed Mentions:
57 Fields:
Translation:
HumansCells
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CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape. Nature. 2019 04; 568(7750):112-116.
Hamieh M, Dobrin A, Cabriolu A, van der Stegen SJC, Giavridis T, Mansilla-Soto J, Eyquem J, Zhao Z, Whitlock BM, Miele MM, Li Z, Cunanan KM, Huse M, Hendrickson RC, Wang X, Rivière I, Sadelain M. PMID: 30918399; PMCID: PMC6707377.
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PubMed Mentions:
307 Fields:
Translation:
AnimalsCells
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Publisher Correction: Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency. Nat Med. 2019 Mar; 25(3):530.
Feucht J, Sun J, Eyquem J, Ho YJ, Zhao Z, Leibold J, Dobrin A, Cabriolu A, Hamieh M, Sadelain M. PMID: 30692700.
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PubMed Mentions:
4 Fields:
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Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency. Nat Med. 2019 01; 25(1):82-88.
Feucht J, Sun J, Eyquem J, Ho YJ, Zhao Z, Leibold J, Dobrin A, Cabriolu A, Hamieh M, Sadelain M. PMID: 30559421; PMCID: PMC6532069.
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PubMed Mentions:
262 Fields:
Translation:
AnimalsCells
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Low-Dose Radiation Conditioning Enables CAR T Cells to Mitigate Antigen Escape. Mol Ther. 2018 11 07; 26(11):2542-2552.
DeSelm C, Palomba ML, Yahalom J, Hamieh M, Eyquem J, Rajasekhar VK, Sadelain M. PMID: 30415658; PMCID: PMC6225039.
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PubMed Mentions:
132 Fields:
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HumansAnimalsCells
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Antibody with Infinite Affinity for In Vivo Tracking of Genetically Engineered Lymphocytes. J Nucl Med. 2018 12; 59(12):1894-1900.
Krebs S, Ahad A, Carter LM, Eyquem J, Brand C, Bell M, Ponomarev V, Reiner T, Meares CF, Gottschalk S, Sadelain M, Larson SM, Weber WA. PMID: 29903928; PMCID: PMC6278895.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade. Nat Med. 2018 06; 24(6):731-738.
Giavridis T, van der Stegen SJC, Eyquem J, Hamieh M, Piersigilli A, Sadelain M. PMID: 29808005; PMCID: PMC6410714.
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PubMed Mentions:
619 Fields:
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HumansAnimalsCells
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Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML. Cancer Cell. 2017 10 09; 32(4):506-519.e5.
Perna F, Berman SH, Soni RK, Mansilla-Soto J, Eyquem J, Hamieh M, Hendrickson RC, Brennan CW, Sadelain M. PMID: 29017060; PMCID: PMC7025434.
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PubMed Mentions:
183 Fields:
Translation:
HumansCells
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Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature. 2017 03 02; 543(7643):113-117.
Eyquem J, Mansilla-Soto J, Giavridis T, van der Stegen SJ, Hamieh M, Cunanan KM, Odak A, Gönen M, Sadelain M. PMID: 28225754; PMCID: PMC5558614.
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PubMed Mentions:
876 Fields:
Translation:
HumansAnimalsCells
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Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies. Cancer Res. 2015 Sep 15; 75(18):3853-64.
Poirot L, Philip B, Schiffer-Mannioui C, Le Clerre D, Chion-Sotinel I, Derniame S, Potrel P, Bas C, Lemaire L, Galetto R, Lebuhotel C, Eyquem J, Cheung GW, Duclert A, Gouble A, Arnould S, Peggs K, Pule M, Scharenberg AM, Smith J. PMID: 26183927.
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PubMed Mentions:
319 Fields:
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HumansAnimalsCells
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A platform for rapid prototyping of synthetic gene networks in mammalian cells. Nucleic Acids Res. 2014 Dec 01; 42(21):13440-51.
Duportet X, Wroblewska L, Guye P, Li Y, Eyquem J, Rieders J, Rimchala T, Batt G, Weiss R. PMID: 25378321; PMCID: PMC4245948.
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PubMed Mentions:
68 Fields:
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HumansAnimalsCells
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Characterization of three loci for homologous gene targeting and transgene expression. Biotechnol Bioeng. 2013 Aug; 110(8):2225-35.
Eyquem J, Poirot L, Galetto R, Scharenberg AM, Smith J. PMID: 23475535.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells