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Clay Gustafson, MD, PhD

Title(s)Assistant Professor, Pediatrics
SchoolSchool of Medicine
Address1550 Fourth St
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    Rice University, Houston, TexasBA1996Biochemistry/English Literature
    University of Texas Medical BranchMD, PhD2005Medicine/Biochemistry and Genetics
    University of Texas SouthwesternPediatrics Residency2008Pediatrics
    University of California San FranciscoHematology/Oncology Fellowship2012Pediatric Hematology/Oncology
    Collapse Awards and Honors
    Alex's Lemonade Stand2012  - 2014ALSF "A" Award

    Collapse Overview 

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface. Cancer Res. 2019 Nov 01; 79(21):5652-5667. Koach J, Holien JK, Massudi H, Carter DR, Ciampa OC, Herath M, Lim T, Seneviratne JA, Milazzo G, Murray JE, McCarroll JA, Liu B, Mayoh C, Keenan B, Stevenson BW, Gorman MA, Bell JL, Doughty L, Hüttelmaier S, Oberthuer A, Fischer M, Gifford AJ, Liu T, Zhang X, Zhu S, Gustafson WC, Haber M, Norris MD, Fletcher JI, Perini G, Parker MW, Cheung BB, Marshall GM. PMID: 31501192.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer Cell. 2019 09 16; 36(3):302-318.e7. Zhang L, He X, Liu X, Zhang F, Huang LF, Potter AS, Xu L, Zhou W, Zheng T, Luo Z, Berry KP, Pribnow A, Smith SM, Fuller C, Jones BV, Fouladi M, Drissi R, Yang ZJ, Gustafson WC, Remke M, Pomeroy SL, Girard EJ, Olson JM, Morrissy AS, Vladoiu MC, Zhang J, Tian W, Xin M, Taylor MD, Potter SS, Roussel MF, Weiss WA, Lu QR. PMID: 31474569.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Technical Note: Simplified and practical pretherapy tumor dosimetry - A feasibility study for 131 I-MIBG therapy of neuroblastoma using 124 I-MIBG PET/CT. Med Phys. 2019 May; 46(5):2477-2486. Seo Y, Huh Y, Huang SY, Hernandez-Pampaloni JM, Hawkins RA, Gustafson WC, Vo KT, Matthay KK. PMID: 30761545.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2. J Clin Invest. 2018 01 02; 128(1):446-462. Chen L, Alexe G, Dharia NV, Ross L, Iniguez AB, Conway AS, Wang EJ, Veschi V, Lam N, Qi J, Gustafson WC, Nasholm N, Vazquez F, Weir BA, Cowley GS, Ali LD, Pantel S, Jiang G, Harrington WF, Lee Y, Goodale A, Lubonja R, Krill-Burger JM, Meyers RM, Tsherniak A, Root DE, Bradner JE, Golub TR, Roberts CW, Hahn WC, Weiss WA, Thiele CJ, Stegmaier K. PMID: 29202477.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    5. Phase 1 study of sirolimus in combination with oral cyclophosphamide and topotecan in children and young adults with relapsed and refractory solid tumors. Oncotarget. 2017 Apr 04; 8(14):23851-23861. Vo KT, Karski EE, Nasholm NM, Allen S, Hollinger F, Gustafson WC, Long-Boyle JR, Shiboski S, Matthay KK, DuBois SG. PMID: 27793021.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    6. A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell. 2017 03 13; 31(3):424-435. Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA. PMID: 28292440.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    7. Erratum to: Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group. Eur J Nucl Med Mol Imaging. 2016 Jul; 43(7):1396. Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Parisi MT, Shulkin BL, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG. PMID: 27044383.
      View in: PubMed   Mentions:    Fields:    
    8. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 2016 Apr 11; 29(4):536-547. Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON. PMID: 27050099.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    9. Rational design of a monomeric and photostable far-red fluorescent protein for fluorescence imaging in vivo. Protein Sci. 2016 Feb; 25(2):308-15. Yu D, Dong Z, Gustafson WC, Ruiz-González R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X. PMID: 26549191.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    10. Extended Sedation With Continuous Midazolam or Dexmedetomidine Infusion for Young Children Receiving 131 I-MIBG Radiopharmaceutical Therapy for Advanced Neuroblastoma. Pediatr Blood Cancer. 2016 Mar; 63(3):471-8. Lee JS, Wu R, Wong T, DuBois SG, Matthay K, Gustafson C, Hawkins R, Roy-Burman A. PMID: 26585842.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Vesicular monoamine transporter protein expression correlates with clinical features, tumor biology, and MIBG avidity in neuroblastoma: a report from the Children's Oncology Group. Eur J Nucl Med Mol Imaging. 2016 Mar; 43(3):474-481. Temple W, Mendelsohn L, Kim GE, Nekritz E, Gustafson WC, Lin L, Giacomini K, Naranjo A, Van Ryn C, Yanik GA, Kreissman SG, Hogarty M, Matthay KK, DuBois SG. PMID: 26338179.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer. Front Oncol. 2015; 5:111. Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC. PMID: 26029667.
      View in: PubMed   Mentions:
    13. A new "angle" on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition. Mol Cell Oncol. 2015 Apr-Jun; 2(2):e975641. Meyerowitz JG, Weiss WA, Gustafson WC. PMID: 27308435.
      View in: PubMed   Mentions:
    14. The genetics of splicing in neuroblastoma. Cancer Discov. 2015 Apr; 5(4):380-95. Chen J, Hackett CS, Zhang S, Song YK, Bell RJ, Molinaro AM, Quigley DA, Balmain A, Song JS, Costello JF, Gustafson WC, Van Dyke T, Kwok PY, Khan J, Weiss WA. PMID: 25637275.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    15. Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell Rep. 2014 Nov 06; 9(3):1034-46. Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, Khan J, Balmain A, Fan Q, Weiss WA. PMID: 25437558.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 2014 Sep 08; 26(3):414-427. Gustafson WC, Meyerowitz JG, Nekritz EA, Chen J, Benes C, Charron E, Simonds EF, Seeger R, Matthay KK, Hertz NT, Eilers M, Shokat KM, Weiss WA. PMID: 25175806.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    17. An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging. Nat Commun. 2014 May 15; 5:3626. Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X. PMID: 24832154.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    18. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science. 2014 Jan 10; 343(6167):189-193. Johnson BE, Mazor T, Hong C, Barnes M, Aihara K, McLean CY, Fouse SD, Yamamoto S, Ueda H, Tatsuno K, Asthana S, Jalbert LE, Nelson SJ, Bollen AW, Gustafson WC, Charron E, Weiss WA, Smirnov IV, Song JS, Olshen AB, Cha S, Zhao Y, Moore RA, Mungall AJ, Jones SJM, Hirst M, Marra MA, Saito N, Aburatani H, Mukasa A, Berger MS, Chang SM, Taylor BS, Costello JF. PMID: 24336570.
      View in: PubMed   Mentions: 399     Fields:    Translation:Humans
    19. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 2013 Oct 14; 24(4):438-49. Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA. PMID: 24135280.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    20. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar; 3(3):308-23. Puissant A, Frumm SM, Alexe G, Bassil CF, Qi J, Chanthery YH, Nekritz EA, Zeid R, Gustafson WC, Greninger P, Garnett MJ, McDermott U, Benes CH, Kung AL, Weiss WA, Bradner JE, Stegmaier K. PMID: 23430699.
      View in: PubMed   Mentions: 211     Fields:    Translation:HumansAnimalsCells
    21. Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model. Mol Imaging Biol. 2012 Dec; 14(6):735-42. Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK. PMID: 22382618.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    22. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12722-7. Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW. PMID: 22802621.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    23. Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma. Sci Transl Med. 2012 Jan 04; 4(115):115ra3. Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, Charron E, Yakovenko S, Kim G, Matthay KK, Weiss WA. PMID: 22218692.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    24. Progress towards personalized therapeutics: biologic- and risk-directed therapy for neuroblastoma. Expert Rev Neurother. 2011 Oct; 11(10):1411-23. Gustafson WC, Matthay KK. PMID: 21955198.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    25. Addiction to B-MYB. Oncotarget. 2010 Aug; 1(4):235-6. Gustafson WC, Weiss WA. PMID: 21304174.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    26. Myc proteins as therapeutic targets. Oncogene. 2010 Mar 04; 29(9):1249-59. Gustafson WC, Weiss WA. PMID: 20101214.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    27. Role of gastrointestinal hormones in neuroblastoma. World J Surg. 2005 Mar; 29(3):281-6. Gustafson WC, De Berry BB, Evers BM, Chung DH. PMID: 15706438.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    28. Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis. J Biol Chem. 2004 Aug 20; 279(34):35604-15. Ray S, Lu Y, Kaufmann SH, Gustafson WC, Karp JE, Boldogh I, Fields AP, Brasier AR. PMID: 15155749.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    29. Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter. J Biol Chem. 2004 Mar 05; 279(10):9400-8. Gustafson WC, Ray S, Jamieson L, Thompson EA, Brasier AR, Fields AP. PMID: 14670960.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    30. Genomic analysis of glucocorticoid-regulated promoters in murine T-lymphoma cells. Recent Prog Horm Res. 2003; 58:155-74. Chen L, Finnerty C, Gustafson WC, Bush CR, Chi P, Guo H, Luxon B, Fields AP, Thompson EA. PMID: 12795418.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    31. Protein kinase C in disease: cancer. Methods Mol Biol. 2003; 233:519-37. Fields AP, Gustafson WC. PMID: 12840532.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    32. Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models. Methods Mol Biol. 2003; 233:539-53. Fields AP, Murray NR, Gustafson WC. PMID: 12840533.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    33. Comparison of GLUT1, GLUT3, and GLUT4 mRNA and the subcellular distribution of their proteins in normal human muscle. Metabolism. 2000 Dec; 49(12):1604-9. Stuart CA, Wen G, Gustafson WC, Thompson EA. PMID: 11145124.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    34. Nucleolar protein p120 contains an arginine-rich domain that binds to ribosomal RNA. Biochem J. 1998 Apr 15; 331 ( Pt 2):387-93. Gustafson WC, Taylor CW, Valdez BC, Henning D, Phippard A, Ren Y, Busch H, Durban E. PMID: 9531475.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    35. Overexpression of human nucleolar proteins in insect cells: characterization of nucleolar protein p120. Protein Expr Purif. 1996 Mar; 7(2):212-9. Ren Y, Busch R, Durban E, Taylor C, Gustafson WC, Valdez B, Li YP, Smetana K, Busch H. PMID: 8812864.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    36. Functional domains of nucleolar phosphoprotein p120. Physiol Chem Phys Med NMR. 1995; 27(4):303-11. Durban E, Valdez BC, Gustafson WC, Taylor CW, Cardellini E, Busch H. PMID: 8768786.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
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