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Alan Wolfe

TitleAssociate Specialist
SchoolUCSF School of Pharmacy
DepartmentBioengineering
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-2307
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    A new, single-dose, oral drug for schistosomiasis: identifying and optimizing the bioactive principles
    Sandler Center for Drug Discovery (no number)Nov 1, 2011 - Oct 31, 2012
    Role: Coinvestigator
    Role Description: Carry out in vitro and rat pharmacokinetic (PK) work to identify path(s) of metabolism. Identify metabolites and analyze rat PK data generated by contract lab.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Benet LZ, Liu S, Wolfe AR. The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clin Pharmacol Ther. 2017 Aug 01. PMID: 28762489.
      View in: PubMed
    2. Monera-Penduka TG, Maponga CC, Wolfe AR, Wiesner L, Morse GD, Nhachi CF. Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study. AIDS Res Ther. 2017 Mar 14; 14(1):12. PMID: 28288665.
      View in: PubMed
    3. De Muylder G, Vanhollebeke B, Caljon G, Wolfe AR, McKerrow J, Dujardin JC. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 Dec; 10(12):e0005234. PMID: 28036391.
      View in: PubMed
    4. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. PMID: 25700363; PMCID: PMC4336141.
    5. Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Transplantation. 2014 Mar 27; 97(6):702-7. PMID: 24389906; PMCID: PMC4018220.
    6. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 2014 Apr 03; 508(7494):93-7. PMID: 24572354; PMCID: PMC4161230.
    7. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51. PMID: 24030928; PMCID: PMC4018225.
    8. Tamraz B, Fukushima H, Wolfe AR, Kaspera R, Totah RA, Floyd JS, Ma B, Chu C, Marciante KD, Heckbert SR, Psaty BM, Kroetz DL, Kwok PY. OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis. Pharmacogenet Genomics. 2013 Jul; 23(7):355-64. PMID: 23652407; PMCID: PMC3894639.
    9. Gwaza L, Wolfe A, Benet LZ, Guglielmo BJ, Chagwedera TE, Maponga CC, Masimirembwa CM. In vitro inhibitory effects of Hypoxis obtusa and Dicoma anomala on cyp450 enzymes and p-glycoprotein. Afr J Pharm Pharmacol. 2009; 3(11):539-546.
    10. Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM. Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women. J Acquir Immune Defic Syndr. 2009 Apr 15; 50(5):482-91. PMID: 19408353; PMCID: PMC2700138.
    11. Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. J Infect Dev Ctries. 2008 Oct 01; 2(5):379-83. PMID: 19745507.
      View in: PubMed
    12. Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Am J Transplant. 2007 Dec; 7(12):2816-20. PMID: 17949460.
      View in: PubMed
    13. Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother. 2005 Dec; 49(12):5160-1. PMID: 16304193; PMCID: PMC1315979.
    14. Wolfe AR, Smith TJ, Meehan T. Benzo[a]pyrene diol epoxide forms covalent adducts with deoxycytidylic acid by alkylation at both exocyclic amino N(4) and ring imino N-3 positions. Chem Res Toxicol. 2004 Apr; 17(4):476-91. PMID: 15089090.
      View in: PubMed
    15. Vock EH, Wolfe AR, Meehan T. Trans- and cis-DNA adduct concentration in epidermis from mouse and rat skin treated ex vivo with benzo[a]pyrene diol epoxide and its corresponding chlorohydrin. Mutat Res. 2001 Jul 01; 478(1-2):199-206. PMID: 11406185.
      View in: PubMed
    16. Plank C, Tang MX, Wolfe A, Szoka FC. Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes (Corrigendum). Hum Gene Ther. 1999; 10(13):322.
    17. Plank C, Tang MX, Wolfe AR, Szoka FC. Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. Hum Gene Ther. 1999 Jan 20; 10(2):319-32. PMID: 10022556.
      View in: PubMed
    18. Song Q, Negrete GR, Wolfe AR, Wang K, Meehan T. Synthesis and characterization of bay region halohydrins derived from Benzo[a]pyrene diol epoxide and their role as intermediates in halide-catalyzed cis adduct formation. Chem Res Toxicol. 1998 Sep; 11(9):1057-66. PMID: 9760280.
      View in: PubMed
    19. Meehan T, Wolfe AR, Negrete GR, Song Q. Benzo[a]pyrene diol epoxide-DNA cis adduct formation through a trans chlorohydrin intermediate. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1749-54. PMID: 9050850; PMCID: PMC19988.
    20. Alan R Wolfe, Qi Song, Thomas Meehan. The effect of temperature on the stereochemistry of adducts and hydrolysis products derived from anti-benzo[a]pyrene diol epoxide in the presence and absence of halide ions. Polycyclic Aromatic Compounds. 1996; 10(1-4):203-210.
    21. Wolfe AR, Meehan T. The effect of sodium ion concentration on intrastrand base-pairing in single-stranded DNA. Nucleic Acids Res. 1994 Aug 11; 22(15):3147-50. PMID: 8065928; PMCID: PMC310288.
    22. Wolfe AR, Yamamoto J, Meehan T. Chloride ions catalyze the formation of cis adducts in the binding of anti-benzo[a]pyrene diol epoxide to nucleic acids. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1371-5. PMID: 8108418; PMCID: PMC43160.
    23. Wolfe AR, Meehan T. Halide-catalyzed cis product formation in the hydrolysis of anti-benzo[a]pyrene diol epoxide and its alkylation of poly(A). Chem Res Toxicol. 1994 Jan-Feb; 7(1):110-9. PMID: 8155819.
      View in: PubMed
    24. Wolfe A, Meehan T. Use of binding site neighbor-effect parameters to evaluate the interactions between adjacent ligands on a linear lattice. Effects on ligand-lattice association. J Mol Biol. 1992 Feb 20; 223(4):1063-87. PMID: 1538390.
      View in: PubMed
    25. Yamamoto J, Subramaniam R, Wolfe A, Meehan T. The formation of covalent adducts between benzo[a]pyrenediol epoxide and RNA: structural analysis by mass spectrometry. Biochemistry. 1990 Apr 24; 29(16):3966-72. PMID: 2354168.
      View in: PubMed
    26. Shimer GH, Wolfe A, Meehan T. Equilibrium binding of benzo[a]pyrene tetrol to synthetic polynucleotides: sequence selectivity, thermodynamic properties, and ionic strength dependence. Biochemistry. 1988 Oct 04; 27(20):7960-6. PMID: 3207722.
      View in: PubMed
    27. Wolfe A, Shimer GH, Meehan T. Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA. Biochemistry. 1987 Oct 06; 26(20):6392-6. PMID: 3427013.
      View in: PubMed
    28. Von Korff RW, Wolfe AR. Saturated amines and diamines as substrates which inhibit beef liver mitochondrial monoamine oxidase. J Bioenerg Biomembr. 1984 Dec; 16(5-6):597-609. PMID: 6537438.
      View in: PubMed
    29. Von Korff RW, Wolfe A . Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects (E. Usdin, N. Weiner, M. B. H. Youdim, Eds.). Anomalies in MAO assays using delta A249 and delta O measurements with benzylamine as substrate . 1981; 565-574.
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