Francis Szoka, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address513 Parnassus Avenue, MSB, #822A
San Francisco CA 94117
Phone415-305-1882
ORCID ORCID Icon0000-0002-6236-0621 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    1980Chancellor's Award for Academic Excellence, University of California San Francisco (with Dr Richard)
    1986Louis W. Busse Lecturer, University of Wisconsin. Madison, Wisconsin
    1990Fellow of the American Association of Pharmaceutical Sciences
    1994Paul Neumann Prize Lecture (with Dr. Jean-Yves Legendre)
    1995Glaxo Lecturer, University of North Carolina, School of Pharmacy. Chapel Hill, North Carolina
    1995Walter F. Enz Lecturer, University of Kansas. Lawrence, Kansas
    1995Keynote Speaker, Pharmaceutical Chemistry Asilomar Retreat, Asilomar, California
    1997Controlled Release Society, Jorge Heller Outstanding Paper Award, Journal of Controlled Release. Sh
    2000Honorary Doctorate in Pharmacy, University of Kuopio. Kuopio, Finland. (June)
    2000American Association of Colleges of Pharmacy- Paul Dawson
    2000Biotechnology Award (July)
    2001America Association of Pharmaceutical Scientists- Career ResearchAchievement Award in Biotechnology
    2006Tenth Alec Bangham Career Achievement Award for Outstanding Liposome Research Award
    2007UCSF Outstanding Faculty Mentorship Award
    2008University of North Carolina- GlaxoSmithKline Faculty Lecturer
    2011Dr. Rainer Hoffman Product Through Science Award
    2016William M. Heller Mentor of the Year, American Foundation for Pharmaceutical Education
    2019Fellow, National Academy of Inventors

    Collapse Overview 
    Collapse Overview
    The Szoka group applies chemical, biophysical and molecular biology approaches to devise vaccine, drug and nucleic acid delivery systems to treat cancer or infectious diseases. These systems can incorporate lipids, peptides, polymers and proteins. These drug carriers are composed of lipids, polymers, peptides or proteins. His group has extensively investigated the role of lipids in membrane fusion and his designed, synthesized and studied the mechanism of fusogenic peptides. With group members, he has published over 220 manuscripts and has received 35 U.S. patents. One FDA approved drug product Amphotec™ and one biotechnology product Superfect™ have been commercialized from the patents. In addition to his University commitments, Dr. Szoka is a founder of Sequus Pharmaceuticals, Inc., GeneMedicine, Inc., and ZoneOne Pharma, Inc. Sequus introduced sterically stabilized liposomes for anti-cancer drug delivery (Doxil™).

    Collapse Research 
    Collapse Research Activities and Funding
    Retargeting FDA Approved Anticancer Liposomal Drugs to Cancer Stem Cells
    NIH R41CA192689Apr 3, 2015 - Dec 31, 2016
    Role: Principal Investigator
    Syngeneic Macrophages for Personalized Cancer Therapy
    NIH R21CA182703Jan 1, 2014 - Dec 31, 2015
    Role: Principal Investigator
    Improving Protein Delivery and Circulation via FcRn Ligands
    NIH R21EB015520Jul 15, 2012 - Jun 30, 2014
    Role: Principal Investigator
    HIV neutralizing antibodies induced by chemically modified MPR epitopes
    NIH R21AI093135Aug 15, 2011 - Jul 31, 2013
    Role: Principal Investigator
    Carolina Center of Cancer Nanotechnology Excellence
    NIH U54CA119343Sep 30, 2005 - Aug 31, 2012
    Role: Co-Investigator
    Pharmacology of Targeted Therapy to Brain Tumors
    NIH R01CA107268Mar 1, 2004 - Feb 28, 2010
    Role: Principal Investigator
    Rational Design of Viral-Mimetic Lipid Gene Vectors
    NIH R01EB003008Sep 22, 2003 - Jun 30, 2015
    Role: Principal Investigator
    Biocompatible Dendritic Polymers for in vivo Applications
    NIH R01EB002047Apr 1, 2002 - Jul 31, 2011
    Role: Principal Investigator
    Biocompatible Dendritic Polymers : In Vivo Applications
    NIH R01GM065361Apr 1, 2002 - Mar 31, 2006
    Role: Principal Investigator
    Targeted Drug Delivery to Surface Receptors.
    NIH R01GM061851Jul 1, 2000 - Feb 28, 2017
    Role: Principal Investigator
    MOLECULAR BASIS OF DRUG TRANSPORT IN THE INTESTINE
    NIH R01GM057656Aug 1, 1997 - Jul 31, 2001
    Role: Co-Investigator
    GENE THERAPY CORE--CYSTIC FIBROSIS &NON-CF GENETIC DIS
    NIH P30DK047766Sep 30, 1993 - Aug 31, 1999
    Role: Co-Investigator
    SYNTHETIC GENE CARRIERS TO TREAT CYSTIC FIBROSIS
    NIH R01DK046052Sep 30, 1992 - Mar 31, 2003
    Role: Principal Investigator
    TARGETED CHEMOTHERAPY TO HIV INFECTED MACROPHAGES
    NIH R01AI025099Jul 1, 1989 - Dec 31, 1992
    Role: Principal Investigator
    CFTR AND AIRWAY PATHOLOGY OF CYSTIC FIBROSIS
    NIH P50HL042368Sep 30, 1988 - Aug 31, 1999
    Role: Co-Investigator
    Pharmaceutical Sciences and Pharmacogenomics
    NIH T32GM007175Jul 1, 1982 - Jun 30, 2022
    Role: Co-Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    CONTROLLED DISPOSITION OF LIPOSOMES
    NIH R01GM030163Feb 1, 1982 - Jun 30, 1996
    Role: Principal Investigator
    MICROINJECTION INTO CELLS BY A LIPOSOME SYSTEM
    NIH R01GM029514Apr 1, 1981 - Nov 30, 1987
    Role: Principal Investigator
    PHARMACOKINETICS/PHARMACODYNAMICS
    NIH P50GM026691Aug 1, 1979 - Jul 31, 1998
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A hitchhiker's guide to mucosal and systemic immunity. Sci Transl Med. 2022 07 20; 14(654):eadc8697. Szoka FC. PMID: 35857822.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Biophysical studies of HIV-1 glycoprotein-41 interactions with peptides and small molecules - Effect of lipids and detergents. Biochim Biophys Acta Gen Subj. 2020 12; 1864(12):129724. Zhou G, Chu S, Kohli A, Szoka FC, Gochin M. PMID: 32889078; PMCID: PMC7540966.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency. Nat Biotechnol. 2020 Jan; 38(1):44-49. Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, Bluestone JA, Puck JM, Szoka FC, Marson A. PMID: 31819258; PMCID: PMC6954310.
      View in: PubMed   Mentions: 118     Fields:    Translation:Humans
    4. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature. 2019 08; 572(7771):614-619. Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. PMID: 31435015; PMCID: PMC6715529.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    5. Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition. PLoS One. 2019; 14(4):e0215218. Dolor A, Sampson SL, Lazar AA, Lotz JC, Szoka FC, Fields AJ. PMID: 30970007; PMCID: PMC6457523.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    6. Development of a flow-through USP 4 apparatus drug release assay for the evaluation of amphotericin B liposome. Eur J Pharm Biopharm. 2019 Jan; 134:107-116. Tang J, Srinivasan S, Yuan W, Ming R, Liu Y, Dai Z, Noble CO, Hayes ME, Zheng N, Jiang W, Szoka FC, Schwendeman A. PMID: 30481559.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    7. Correction: Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation. Chem Commun (Camb). 2018 11 13; 54(91):12891. Dolor A, Kierstead P, Dai Z, Szoka FC. PMID: 30387791.
      View in: PubMed   Mentions:    Fields:    
    8. Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation. Chem Commun (Camb). 2018 Oct 28; 54(84):11949-11952. Dolor A, Kierstead P, Dai Z, Szoka FC. PMID: 30288531; PMCID: PMC6764448.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    9. Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery. Mol Pharm. 2018 06 04; 15(6):2069-2083. Dolor A, Szoka FC. PMID: 29767984; PMCID: PMC6764447.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    10. Constrained Versus Free Cholesterol in DPPC Membranes: A Comparison of Chain Ordering Ability Using Deuterium NMR. Langmuir. 2017 12 19; 33(50):14405-14413. Shaghaghi M, Keyvanloo A, Huang Z, Szoka FC, Thewalt JL. PMID: 29120186.
      View in: PubMed   Mentions: 2     Fields:    
    11. Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice. Mol Ther Methods Clin Dev. 2017 Dec 15; 7:60-73. Lee S, Kivimäe S, Szoka FC. PMID: 29034260; PMCID: PMC5633862.
      View in: PubMed   Mentions: 2  
    12. Biodistribution and In Vivo Antileishmanial Activity of 1,2-Distigmasterylhemisuccinoyl-sn-Glycero-3-Phosphocholine Liposome-Intercalated Amphotericin B. Antimicrob Agents Chemother. 2017 09; 61(9). Iman M, Huang Z, Alavizadeh SH, Szoka FC, Jaafari MR. PMID: 28630182; PMCID: PMC5571372.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    13. Encapsulation, controlled release, and antitumor efficacy of cisplatin delivered in liposomes composed of sterol-modified phospholipids. Eur J Pharm Sci. 2017 May 30; 103:85-93. Kieler-Ferguson HM, Chan D, Sockolosky J, Finney L, Maxey E, Vogt S, Szoka FC. PMID: 28263913; PMCID: PMC5473525.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. Co-localization of fluorescent labeled lipid nanoparticles with specifically tagged subcellular compartments by single particle tracking at low nanoparticle to cell ratios. J Drug Target. 2016 11; 24(9):857-864. Tiffany M, Szoka FC. PMID: 27600702.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Development of a Flow-Through USP-4 Apparatus Drug Release Assay to Evaluate Doxorubicin Liposomes. AAPS J. 2017 01; 19(1):150-160. Yuan W, Kuai R, Dai Z, Yuan Y, Zheng N, Jiang W, Noble C, Hayes M, Szoka FC, Schwendeman A. PMID: 27485642.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    16. Macrophage-based cell therapies: The long and winding road. J Control Release. 2016 10 28; 240:527-540. Lee S, Kivimäe S, Dolor A, Szoka FC. PMID: 27422609; PMCID: PMC5064880.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    17. The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes. J Control Release. 2015 Sep 10; 213:1-9. Kierstead PH, Okochi H, Venditto VJ, Chuong TC, Kivimae S, Fréchet JMJ, Szoka FC. PMID: 26093095; PMCID: PMC4684485.
      View in: PubMed   Mentions: 47     Fields:    Translation:Animals
    18. The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy. Adv Drug Deliv Rev. 2015 Aug 30; 91:109-24. Sockolosky JT, Szoka FC. PMID: 25703189; PMCID: PMC4544678.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimals
    19. Sulfated quaternary amine lipids: a new class of inverse charge zwitterlipids. Chem Commun (Camb). 2014 Aug 21; 50(65):9109-11. Venditto VJ, Dolor A, Kohli A, Salentinig S, Boyd BJ, Szoka FC. PMID: 24984814; PMCID: PMC4214375.
      View in: PubMed   Mentions: 2     Fields:    
    20. Fusion of a short peptide that binds immunoglobulin G to a recombinant protein substantially increases its plasma half-life in mice. PLoS One. 2014; 9(7):e102566. Sockolosky JT, Kivimäe S, Szoka FC. PMID: 25057984; PMCID: PMC4109916.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    21. Chemically modified peptides based on the membrane-proximal external region of the HIV-1 envelope induce high-titer, epitope-specific nonneutralizing antibodies in rabbits. Clin Vaccine Immunol. 2014 Aug; 21(8):1086-93. Venditto VJ, Wieczorek L, Molnar S, Teque F, Landucci G, Watson DS, Forthal D, Polonis VR, Levy JA, Szoka FC. PMID: 24872518; PMCID: PMC4135905.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronan. J Control Release. 2014 Oct 10; 191:105-14. Kohli AG, Kivimäe S, Tiffany MR, Szoka FC. PMID: 24852095; PMCID: PMC4156903.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    23. Designer lipids for drug delivery: from heads to tails. J Control Release. 2014 Sep 28; 190:274-87. Kohli AG, Kierstead PH, Venditto VJ, Walsh CL, Szoka FC. PMID: 24816069; PMCID: PMC4142081.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    24. Chemoenzymatic synthesis of oligohyaluronan-lipid conjugates. Bioconjug Chem. 2014 Apr 16; 25(4):718-23. Ruhela D, Kivimäe S, Szoka FC. PMID: 24646444; PMCID: PMC3993934.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    25. A robust and quantitative method for tracking liposome contents after intravenous administration. J Control Release. 2014 Feb 28; 176:86-93. Kohli AG, Kieler-Ferguson HM, Chan D, Szoka FC. PMID: 24368300; PMCID: PMC4040254.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    26. Novel ortho ester-based, pH-sensitive cationic lipid for gene delivery in vitro and in vivo. J Liposome Res. 2014 Jun; 24(2):90-8. Guo X, Gagne L, Chen H, Szoka FC. PMID: 24188532.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    27. Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease. PLoS One. 2013; 8(2):e56026. Li M, Yasumura D, Ma AA, Matthes MT, Yang H, Nielson G, Huang Y, Szoka FC, Lavail MM, Diamond MI. PMID: 23409115; PMCID: PMC3569418.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    28. Clinical developments of chemotherapeutic nanomedicines: polymers and liposomes for delivery of camptothecins and platinum (II) drugs. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Mar-Apr; 5(2):130-8. Kieler-Ferguson HM, Fréchet JM, Szoka FC. PMID: 23335566.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    29. Synthesis, characterization, and evaluation of ionizable lysine-based lipids for siRNA delivery. Bioconjug Chem. 2013 Jan 16; 24(1):36-43. Walsh CL, Nguyen J, Tiffany MR, Szoka FC. PMID: 23176544; PMCID: PMC3586539.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    30. Periplasmic production via the pET expression system of soluble, bioactive human growth hormone. Protein Expr Purif. 2013 Feb; 87(2):129-35. Sockolosky JT, Szoka FC. PMID: 23168094; PMCID: PMC3537859.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    31. Rational design of membrane proximal external region lipopeptides containing chemical modifications for HIV-1 vaccination. Clin Vaccine Immunol. 2013 Jan; 20(1):39-45. Venditto VJ, Watson DS, Motion M, Montefiori D, Szoka FC. PMID: 23114698; PMCID: PMC3535774.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsPHPublic Health
    32. Cancer nanomedicines: so many papers and so few drugs! Adv Drug Deliv Rev. 2013 Jan; 65(1):80-8. Venditto VJ, Szoka FC. PMID: 23036224; PMCID: PMC3565003.
      View in: PubMed   Mentions: 137     Fields:    Translation:Humans
    33. Engineering neonatal Fc receptor-mediated recycling and transcytosis in recombinant proteins by short terminal peptide extensions. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16095-100. Sockolosky JT, Tiffany MR, Szoka FC. PMID: 22991460; PMCID: PMC3479544.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    34. Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds. Angew Chem Int Ed Engl. 2012 Sep 03; 51(36):9047-51. Motion JP, Nguyen J, Szoka FC. PMID: 22887437; PMCID: PMC3470804.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    35. Controlled nucleation of lipid nanoparticles. Pharm Res. 2012 Aug; 29(8):2236-48. Nguyen J, Walsh CL, Motion JP, Perttu EK, Szoka F. PMID: 22544683.
      View in: PubMed   Mentions: 6     Fields:    
    36. Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties. Chem Commun (Camb). 2012 Jun 07; 48(45):5575-7. Walsh CL, Nguyen J, Szoka FC. PMID: 22538384.
      View in: PubMed   Mentions: 12     Fields:    
    37. Nucleic acid delivery: the missing pieces of the puzzle? Acc Chem Res. 2012 Jul 17; 45(7):1153-62. Nguyen J, Szoka FC. PMID: 22428908; PMCID: PMC3399092.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    38. Inverse-phosphocholine lipids: a remix of a common phospholipid. J Am Chem Soc. 2012 Mar 14; 134(10):4485-8. Perttu EK, Kohli AG, Szoka FC. PMID: 22364493; PMCID: PMC3303984.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    39. Synthesis and characterization of betaine-like diacyl lipids: zwitterionic lipids with the cationic amine at the bilayer interface. Chem Phys Lipids. 2012 Feb; 165(2):252-9. Kohli AG, Walsh CL, Szoka FC. PMID: 22301334; PMCID: PMC3288814.
      View in: PubMed   Mentions: 4     Fields:    
    40. Zwitterionic sulfobetaine lipids that form vesicles with salt-dependent thermotropic properties. Chem Commun (Camb). 2011 Dec 21; 47(47):12613-5. Perttu EK, Szoka FC. PMID: 22045250.
      View in: PubMed   Mentions: 8     Fields:    
    41. Asymmetric 1-alkyl-2-acyl phosphatidylcholine: a helper lipid for enhanced non-viral gene delivery. Int J Pharm. 2012 May 01; 427(1):64-70. Huang Z, Li W, Szoka FC. PMID: 21718766; PMCID: PMC3207009.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    42. Structural studies of the monolayers and bilayers formed by a novel cholesterol-phospholipid chimera. Langmuir. 2011 Jul 05; 27(13):8275-81. Foglia F, Barlow DJ, Szoka FC, Huang Z, Rogers SE, Lawrence MJ. PMID: 21634402.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    43. Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecan. J Control Release. 2011 Aug 10; 153(3):288-96. Riviere K, Kieler-Ferguson HM, Jerger K, Szoka FC. PMID: 21600250; PMCID: PMC3148779.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    44. Synthesis and properties of star-comb polymers and their doxorubicin conjugates. Bioconjug Chem. 2011 Apr 20; 22(4):617-24. Chen B, van der Poll DG, Jerger K, Floyd WC, Fréchet JM, Szoka FC. PMID: 21375296; PMCID: PMC3101114.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    45. Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion. Phys Chem Chem Phys. 2011 Mar 28; 13(12):5346-52. Guy RH, Szoka FC. PMID: 21286598.
      View in: PubMed   Mentions: 2     Fields:    
    46. Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a di-stigma-steryl-hemi-succinoyl-glycero-phosphocholine liposome-intercalated amphotericin B. Int J Pharm. 2011 Apr 15; 408(1-2):163-72. Iman M, Huang Z, Szoka FC, Jaafari MR. PMID: 21277963; PMCID: PMC3071037.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    47. Chemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in c26 tumor bearing mice. ChemMedChem. 2011 Jan 03; 6(1):49-53. Floyd WC, Datta GK, Imamura S, Kieler-Ferguson HM, Jerger K, Patterson AW, Fox ME, Szoka FC, Fréchet JM, Ellman JA. PMID: 20973119; PMCID: PMC3470805.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    48. Antibody response to polyhistidine-tagged peptide and protein antigens attached to liposomes via lipid-linked nitrilotriacetic acid in mice. Clin Vaccine Immunol. 2011 Feb; 18(2):289-97. Watson DS, Platt VM, Cao L, Venditto VJ, Szoka FC. PMID: 21159923; PMCID: PMC3067350.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    49. Convection and retro-convection enhanced delivery: some theoretical considerations related to drug targeting. Pharm Res. 2011 Mar; 28(3):472-9. Motion JP, Huynh GH, Szoka FC, Siegel RA. PMID: 20963628; PMCID: PMC3044083.
      View in: PubMed   Mentions: 3     Fields:    
    50. Influence of multivalent nitrilotriacetic acid lipid-ligand affinity on the circulation half-life in mice of a liposome-attached His6-protein. Bioconjug Chem. 2010 May 19; 21(5):892-902. Platt V, Huang Z, Cao L, Tiffany M, Riviere K, Szoka FC. PMID: 20384362; PMCID: PMC2874083.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    51. Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer. Bioconjug Chem. 2010 Apr 21; 21(4):764-73. van der Poll DG, Kieler-Ferguson HM, Floyd WC, Guillaudeu SJ, Jerger K, Szoka FC, Fréchet JM. PMID: 20353169; PMCID: PMC2884961.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    52. Antitumor effect of folate-targeted liposomal doxorubicin in KB tumor-bearing mice after intravenous administration. J Drug Target. 2011 Jan; 19(1):14-24. Riviere K, Huang Z, Jerger K, Macaraeg N, Szoka FC. PMID: 20353291; PMCID: PMC2999654.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    53. Utilizing the O-antigen lipopolysaccharide biosynthesis pathway in Escherichia coli to interrogate the substrate specificities of exogenous glycosyltransferase genes in a combinatorial approach. Glycobiology. 2010 Jun; 20(6):763-74. Johansen EB, Szoka FC, Zaleski A, Apicella MA, Gibson BW. PMID: 20208062; PMCID: PMC2900885.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    54. Synthesis and in vivo antitumor efficacy of PEGylated poly(l-lysine) dendrimer-camptothecin conjugates. Mol Pharm. 2009 Sep-Oct; 6(5):1562-72. Fox ME, Guillaudeu S, Fréchet JM, Jerger K, Macaraeg N, Szoka FC. PMID: 19588994; PMCID: PMC2765109.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    55. Soluble polymer carriers for the treatment of cancer: the importance of molecular architecture. Acc Chem Res. 2009 Aug 18; 42(8):1141-51. Fox ME, Szoka FC, Fréchet JM. PMID: 19555070; PMCID: PMC2759385.
      View in: PubMed   Mentions: 141     Fields:    Translation:Cells
    56. Tris-nitrilotriacetic acids of subnanomolar affinity toward hexahistidine tagged molecules. Bioconjug Chem. 2009 Aug 19; 20(8):1667-72. Huang Z, Hwang P, Watson DS, Cao L, Szoka FC. PMID: 19650657; PMCID: PMC2889198.
      View in: PubMed   Mentions: 19     Fields:    Translation:Cells
    57. All-trans retinoic acid potentiates the antibody response in mice to a lipopeptide antigen adjuvanted with liposomal lipid A. Immunol Cell Biol. 2009 Nov-Dec; 87(8):630-3. Watson DS, Huang Z, Szoka FC. PMID: 19597529; PMCID: PMC2784135.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    58. Role of lipid structure in the humoral immune response in mice to covalent lipid-peptides from the membrane proximal region of HIV-1 gp41. Vaccine. 2009 Jul 23; 27(34):4672-83. Watson DS, Szoka FC. PMID: 19520200; PMCID: PMC2730955.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    59. The influence of polymer topology on pharmacokinetics: differences between cyclic and linear PEGylated poly(acrylic acid) comb polymers. J Control Release. 2009 Dec 16; 140(3):203-9. Chen B, Jerger K, Fréchet JM, Szoka FC. PMID: 19465070; PMCID: PMC2788102.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    60. Antitumor therapy mediated by 5-fluorocytosine and a recombinant fusion protein containing TSG-6 hyaluronan binding domain and yeast cytosine deaminase. Mol Pharm. 2009 May-Jun; 6(3):801-12. Park JI, Cao L, Platt VM, Huang Z, Stull RA, Dy EE, Sperinde JJ, Yokoyama JS, Szoka FC. PMID: 19265397; PMCID: PMC2706098.
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    61. Dependence of pharmacokinetics and biodistribution on polymer architecture: effect of cyclic versus linear polymers. J Am Chem Soc. 2009 Mar 25; 131(11):3842-3. Nasongkla N, Chen B, Macaraeg N, Fox ME, Fréchet JM, Szoka FC. PMID: 19256497; PMCID: PMC2668136.
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    62. Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection. J Control Release. 2009 Apr 17; 135(2):166-74. Cohen RN, van der Aa MA, Macaraeg N, Lee AP, Szoka FC. PMID: 19211029; PMCID: PMC2765102.
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    63. Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery. Angew Chem Int Ed Engl. 2009; 48(23):4146-9. Huang Z, Jaafari MR, Szoka FC. PMID: 19425026; PMCID: PMC2773798.
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    64. Sterol-modified phospholipids: cholesterol and phospholipid chimeras with improved biomembrane properties. J Am Chem Soc. 2008 Nov 19; 130(46):15702-12. Huang Z, Szoka FC. PMID: 18950160; PMCID: PMC2701441.
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    65. Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor. Mol Pharm. 2008 Jul-Aug; 5(4):474-86. Platt VM, Szoka FC. PMID: 18547053; PMCID: PMC2772999.
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    66. HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced delivery. Mol Ther. 2008 May; 16(5):893-900. MacKay JA, Li W, Huang Z, Dy EE, Huynh G, Tihan T, Collins R, Deen DF, Szoka FC. PMID: 18388927.
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    67. Molecular biology. The art of assembly. Science. 2008 Feb 01; 319(5863):578-9. Szoka F. PMID: 18239114.
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    68. PEGylated dendrimers with core functionality for biological applications. Bioconjug Chem. 2008 Feb; 19(2):461-9. Guillaudeu SJ, Fox ME, Haidar YM, Dy EE, Szoka FC, Fréchet JM. PMID: 18173227.
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    69. Unsaturated cationic ortho esters for endosome permeation in gene delivery. J Med Chem. 2007 Sep 06; 50(18):4269-78. Chen H, Zhang H, McCallum CM, Szoka FC, Guo X. PMID: 17691717.
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    70. Reconstitution of the M13 major coat protein and its transmembrane peptide segment on a DNA template. Biochemistry. 2007 Jul 24; 46(29):8579-91. Li W, Suez I, Szoka FC. PMID: 17595059.
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    71. Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells. Mol Med. 2007 Mar-Apr; 13(3-4):190-8. Karpuj MV, Giles K, Gelibter-Niv S, Scott MR, Lingappa VR, Szoka FC, Peretz D, Denetclaw W, Prusiner SB. PMID: 17592554; PMCID: PMC1892763.
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    72. Lipid-based nanoparticles for nucleic acid delivery. Pharm Res. 2007 Mar; 24(3):438-49. Li W, Szoka FC. PMID: 17252188.
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    73. Retro-convection enhanced delivery to increase blood to brain transfer of macromolecules. Brain Res. 2007 Jan 12; 1128(1):181-90. Huynh GH, Ozawa T, Deen DF, Tihan T, Szoka FC. PMID: 17125752.
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    74. Facile synthesis of multivalent nitrilotriacetic acid (NTA) and NTA conjugates for analytical and drug delivery applications. Bioconjug Chem. 2006 Nov-Dec; 17(6):1592-600. Huang Z, Park JI, Watson DS, Hwang P, Szoka FC. PMID: 17105240.
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    75. A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16649-54. Lee CC, Gillies ER, Fox ME, Guillaudeu SJ, Fréchet JM, Dy EE, Szoka FC. PMID: 17075050; PMCID: PMC1636509.
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    76. Efficient synthesis of an aldehyde functionalized hyaluronic acid and its application in the preparation of hyaluronan-lipid conjugates. Bioconjug Chem. 2006 Sep-Oct; 17(5):1360-3. Ruhela D, Riviere K, Szoka FC. PMID: 16984148.
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    77. An intramolecular cyclization reaction is responsible for the in vivo inefficacy and apparent pH insensitive hydrolysis kinetics of hydrazone carboxylate derivatives of doxorubicin. Bioconjug Chem. 2006 Sep-Oct; 17(5):1364-8. Lee CC, Cramer AT, Szoka FC, Fréchet JM. PMID: 16984149.
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    78. Bioresponsive targeted charge neutral lipid vesicles for systemic gene delivery. CSH Protoc. 2006 Jun 01; 2006(1). Li W, Szoka FC. PMID: 22485781.
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    81. Barriers to carrier mediated drug and gene delivery to brain tumors. J Control Release. 2006 Jan 10; 110(2):236-259. Huynh GH, Deen DF, Szoka FC. PMID: 16318895.
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    82. In vitro and in vivo evaluation of hydrophilic dendronized linear polymers. Bioconjug Chem. 2005 May-Jun; 16(3):535-41. Lee CC, Yoshida M, Fréchet JM, Dy EE, Szoka FC. PMID: 15898719.
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    83. Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers. Mol Ther. 2005 Mar; 11(3):409-17. Huang Z, Li W, MacKay JA, Szoka FC. PMID: 15727937.
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    84. Biological evaluation of polyester dendrimer: poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture. Mol Pharm. 2005 Mar-Apr; 2(2):129-38. Gillies ER, Dy E, Fréchet JM, Szoka FC. PMID: 15804187.
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    85. Toroid formation in charge neutralized flexible or semi-flexible biopolymers: potential pathway for assembly of DNA carriers. J Gene Med. 2005 Mar; 7(3):334-42. Tang MX, Li W, Szoka FC. PMID: 15515145.
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    86. Identification of a deoxyribonuclease I inhibitor from a phage-peptide library. Mol Cells. 2005 Feb 28; 19(1):54-9. Choi SJ, Sperinde JJ, Szoka FC. PMID: 15750340.
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    87. Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating. Brain Res. 2005 Feb 28; 1035(2):139-53. MacKay JA, Deen DF, Szoka FC. PMID: 15722054.
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    88. Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery. J Gene Med. 2005 Jan; 7(1):67-79. Li W, Huang Z, MacKay JA, Grube S, Szoka FC. PMID: 15515149.
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    89. Molecular motors as drug delivery vehicles. Drug Discov Today Technol. 2005; 2(1):111-8. Cohen RN, Rashkin MJ, Wen X, Szoka FC. PMID: 24981763.
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    90. GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery. Adv Drug Deliv Rev. 2004 Apr 23; 56(7):967-85. Li W, Nicol F, Szoka FC. PMID: 15066755.
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    91. Determination and modeling of kinetics of cancer cell killing by doxorubicin and doxorubicin encapsulated in targeted liposomes. Cancer Res. 2004 Jan 15; 64(2):711-8. Eliaz RE, Nir S, Marty C, Szoka FC. PMID: 14744789.
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    92. Interactions of hyaluronan-targeted liposomes with cultured cells: modeling of binding and endocytosis. Methods Enzymol. 2004; 387:16-33. Eliaz RE, Nir S, Szoka FC. PMID: 15172155.
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    93. Improved preparation of PEG-diortho ester-diacyl glycerol conjugates. Methods Enzymol. 2004; 387:147-52. Guo X, Huang Z, Szoka FC. PMID: 15172162.
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    94. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem. 2003 Nov 07; 278(45):44826-31. Sonawane ND, Szoka FC, Verkman AS. PMID: 12944394.
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    95. Chemical approaches to triggerable lipid vesicles for drug and gene delivery. Acc Chem Res. 2003 May; 36(5):335-41. Guo X, Szoka FC. PMID: 12755643.
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    96. Development of a high throughput Pseudomonas aeruginosa epithelial cell adhesion assay. J Microbiol Methods. 2003 Mar; 52(3):361-6. Swanson B, Savel R, Szoka F, Sawa T, Wiener-Kronish J. PMID: 12531505.
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    97. Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization. Bioconjug Chem. 2003 Mar-Apr; 14(2):420-9. Choi JS, MacKay JA, Szoka FC. PMID: 12643753.
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    98. Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid. Biophys J. 2003 Mar; 84(3):1784-95. Guo X, MacKay JA, Szoka FC. PMID: 12609880; PMCID: PMC1302747.
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    99. HIV TAT Protein Transduction Domain Mediated Cell Binding and Intracellular Delivery of Nanoparticles. J Dispers Sci Technol. 2003; 24(3):465-473. Mackay JA, Szoka FC. PMID: 20808712; PMCID: PMC2929673.
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    101. Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation. Bioconjug Chem. 2002 May-Jun; 13(3):453-61. Padilla De Jesús OL, Ihre HR, Gagne L, Fréchet JM, Szoka FC. PMID: 12009933.
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    102. Polyester dendritic systems for drug delivery applications: design, synthesis, and characterization. Bioconjug Chem. 2002 May-Jun; 13(3):443-52. Ihre HR, Padilla De Jesús OL, Szoka FC, Fréchet JM. PMID: 12009932.
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    103. Mechanism of lipoplex gene delivery in mouse lung: binding and internalization of fluorescent lipid and DNA components. Gene Ther. 2001 Jun; 8(11):828-36. Uyechi LS, Gagné L, Thurston G, Szoka FC. PMID: 11423930.
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    104. Branched polyamines cure prion-infected neuroblastoma cells. J Virol. 2001 Apr; 75(7):3453-61. Supattapone S, Wille H, Uyechi L, Safar J, Tremblay P, Szoka FC, Cohen FE, Prusiner SB, Scott MR. PMID: 11238871; PMCID: PMC114138.
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    105. Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells. Cancer Res. 2001 Mar 15; 61(6):2592-601. Eliaz RE, Szoka FC. PMID: 11289136.
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    106. Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG--diortho ester--lipid conjugate. Bioconjug Chem. 2001 Mar-Apr; 12(2):291-300. Guo X, Szoka FC. PMID: 11312691.
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    107. Phage display selection of a peptide DNase II inhibitor that enhances gene delivery. J Gene Med. 2001 Mar-Apr; 3(2):101-8. Sperinde JJ, Choi SJ, Szoka FC. PMID: 11318108.
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    108. Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in vitro- converted Sup35 protein. Science. 2000 Jul 28; 289(5479):595-9. Sparrer HE, Santoso A, Szoka FC, Weissman JS. PMID: 10915616.
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    109. Fluorometric determination of deoxyribonuclease I activity with PicoGreen. Anal Biochem. 2000 May 15; 281(1):95-7. Choi SJ, Szoka FC. PMID: 10847615.
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    110. Effect of phospholipid composition on an amphipathic peptide-mediated pore formation in bilayer vesicles. Biophys J. 2000 Feb; 78(2):818-29. Nicol F, Nir S, Szoka FC. PMID: 10653794; PMCID: PMC1300684.
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    111. Gene delivery and expression in human retinal pigment epithelial cells: effects of synthetic carriers, serum, extracellular matrix and viral promoters. J Drug Target. 2000; 7(6):413-21. Urtti A, Polansky J, Lui GM, Szoka FC. PMID: 10758912.
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    112. Controlled template-assisted assembly of plasmid DNA into nanometric particles with high DNA concentration. Bioconjug Chem. 2000 Jan-Feb; 11(1):104-12. Ouyang M, Remy JS, Szoka FC. PMID: 10639092.
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    113. Simple mixing device to reproducibly prepare cationic lipid-DNA complexes (lipoplexes). Biotechniques. 1999 Aug; 27(2):286-90. Hirota S, de Ilarduya CT, Barron LG, Szoka FC. PMID: 10457833.
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    114. Lipoplex-mediated gene delivery to the lung occurs within 60 minutes of intravenous administration. Hum Gene Ther. 1999 Jul 01; 10(10):1683-94. Barron LG, Gagné L, Szoka FC. PMID: 10428213.
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    116. Cationic lipids are essential for gene delivery mediated by intravenous administration of lipoplexes. Gene Ther. 1999 Jun; 6(6):1179-83. Barron LG, Uyechi LS, Szoka FC. PMID: 10455423.
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    117. Orientation of the pore-forming peptide GALA in POPC vesicles determined by a BODIPY-avidin/biotin binding assay. Biophys J. 1999 Apr; 76(4):2121-41. Nicol F, Nir S, Szoka FC. PMID: 10096907; PMCID: PMC1300185.
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    118. Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. Hum Gene Ther. 1999 Jan 20; 10(2):319-32. Plank C, Tang MX, Wolfe AR, Szoka FC. PMID: 10022556.
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    119. Efficient adventitial gene delivery to rabbit carotid artery with cationic polymer-plasmid complexes. Gene Ther. 1999 Jan; 6(1):6-11. Turunen MP, Hiltunen MO, Ruponen M, Virkamäki L, Szoka FC, Urtti A, Ylä-Herttuala S. PMID: 10341870.
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    123. Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery. J Med Chem. 1998 Jun 18; 41(13):2207-15. Wang J, Guo X, Xu Y, Barron L, Szoka FC. PMID: 9632353.
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    128. Enhanced transepithelial transport of peptides by conjugation to cholic acid. Bioconjug Chem. 1997 Jul-Aug; 8(4):520-5. Swaan PW, Hillgren KM, Szoka FC, Oie S. PMID: 9258450.
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    129. Many are probed, but few are chosen. Nat Biotechnol. 1997 Jun; 15(6):509. Szoka FC. PMID: 9181566.
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    132. Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity. Pharm Res. 1997 Feb; 14(2):176-80. Kågedahl M, Swaan PW, Redemann CT, Tang M, Craik CS, Szoka FC, Oie S. PMID: 9090705.
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    148. Cyclic amphipathic peptide-DNA complexes mediate high-efficiency transfection of adherent mammalian cells. Proc Natl Acad Sci U S A. 1993 Feb 01; 90(3):893-7. Legendre JY, Szoka FC. PMID: 7679217; PMCID: PMC45776.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    149. Single-stranded phosphodiester and phosphorothioate oligonucleotides bind actinomycin D and interfere with tumor necrosis factor-induced lysis in the L929 cytotoxicity assay. Antisense Res Dev. 1993; 3(3):295-300. Stull RA, Zon G, Szoka FC. PMID: 8286930.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    150. Synthesis and characterization of a trigalactosylated bisacridine compound to target DNA to hepatocytes. Bioconjug Chem. 1993 Jan-Feb; 4(1):85-93. Haensler J, Szoka FC. PMID: 8431516.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    151. Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes. Pharm Res. 1992 Oct; 9(10):1235-42. Legendre JY, Szoka FC. PMID: 1448419.
      View in: PubMed   Mentions: 50     Fields:    Translation:Cells
    152. Predicting antisense oligonucleotide inhibitory efficacy: a computational approach using histograms and thermodynamic indices. Nucleic Acids Res. 1992 Jul 11; 20(13):3501-8. Stull RA, Taylor LA, Szoka FC. PMID: 1352874; PMCID: PMC312508.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    153. Amino acid side-chain contributions to free energy of transfer of tripeptides from water to octanol. Pharm Res. 1992 Apr; 9(4):504-14. Kim A, Szoka FC. PMID: 1495896.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    154. The macrophage as the principal antigen-presenting cell for liposome-encapsulated antigen. Res Immunol. 1992 Feb; 143(2):186-8. Szoka FC. PMID: 1574644.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    155. Prolonged systemic delivery of peptide drugs by long-circulating liposomes: illustration with vasopressin in the Brattleboro rat. Pharm Res. 1992 Feb; 9(2):260-5. Woodle MC, Storm G, Newman MS, Jekot JJ, Collins LR, Martin FJ, Szoka FC. PMID: 1553352.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    156. Iontophoretic delivery of a series of tripeptides across the skin in vitro. Pharm Res. 1991 Sep; 8(9):1121-7. Green PG, Hinz RS, Kim A, Szoka FC, Guy RH. PMID: 1788157.
      View in: PubMed   Mentions: 19     Fields:    
    157. Secondary structure and orientation of the amphipathic peptide GALA in lipid structures. An infrared-spectroscopic approach. Eur J Biochem. 1991 Jan 30; 195(2):421-9. Goormaghtigh E, De Meutter J, Szoka F, Cabiaux V, Parente RA, Ruysschaert JM. PMID: 1997324.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    158. Rapid nuclear accumulation of injected oligodeoxyribonucleotides. New Biol. 1990 Dec; 2(12):1091-100. Chin DJ, Green GA, Zon G, Szoka FC, Straubinger RM. PMID: 1708281.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    159. The future of liposomal drug delivery. Biotechnol Appl Biochem. 1990 Oct; 12(5):496-500. Szoka FC. PMID: 2288703.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    160. Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA. Biochemistry. 1990 Sep 18; 29(37):8720-8. Parente RA, Nir S, Szoka FC. PMID: 2271552.
      View in: PubMed   Mentions: 69     Fields:    Translation:Cells
    161. Association of a pH-sensitive peptide with membrane vesicles: role of amino acid sequence. Biochemistry. 1990 Sep 18; 29(37):8713-9. Parente RA, Nadasdi L, Subbarao NK, Szoka FC. PMID: 2271551.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    162. Efficiency of cytoplasmic delivery by pH-sensitive liposomes to cells in culture. Pharm Res. 1990 Aug; 7(8):824-34. Chu CJ, Dijkstra J, Lai MZ, Hong K, Szoka FC. PMID: 2172955.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    163. Fibre optic sensor for the detection of potassium using fluorescence energy transfer. Analyst. 1990 Apr; 115(4):353-8. Roe JN, Szoka FC, Verkman AS. PMID: 2363517.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    164. Antigen presentation by B cells and macrophages of cytochrome c and its antigenic fragment when conjugated to the surface of liposomes. Vaccine. 1989 Oct; 7(5):401-8. Dal Monte PR, Szoka FC. PMID: 2554605.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    165. Optical measurement of aqueous potassium concentration by a hydrophobic indicator in lipid vesicles. Biophys Chem. 1989 Jul; 33(3):295-302. Roe JN, Szoka FC, Verkman AS. PMID: 2804247.
      View in: PubMed   Mentions: 2     Fields:    
    166. Treatment of experimental invasive aspergillosis with novel amphotericin B/cholesterol-sulfate complexes. J Infect Dis. 1989 Apr; 159(4):717-24. Patterson TF, Miniter P, Dijkstra J, Szoka FC, Ryan JL, Andriole VT. PMID: 2926162.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    167. Effect of liposome encapsulation on antigen presentation in vitro. Comparison of presentation by peritoneal macrophages and B cell tumors. J Immunol. 1989 Mar 01; 142(5):1437-43. Dal Monte P, Szoka FC. PMID: 2465339.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    168. A procedure for the efficient incorporation of wild-type lipopolysaccharide into liposomes for use in immunological studies. J Immunol Methods. 1988 Nov 10; 114(1-2):197-205. Dijkstra J, Ryan JL, Szoka FC. PMID: 3263442.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    169. Increased efficacy of phosphonoformate and phosphonoacetate inhibition of herpes simplex virus type 2 replication by encapsulation in liposomes. Antimicrob Agents Chemother. 1988 Jun; 32(6):858-64. Szoka FC, Chu CJ. PMID: 2843083; PMCID: PMC172296.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    170. Incorporation of LPS in liposomes diminishes its ability to induce tumoricidal activity and tumor necrosis factor secretion in murine macrophages. J Leukoc Biol. 1988 May; 43(5):436-44. Dijkstra J, Larrick JW, Ryan JL, Szoka FC. PMID: 3131472.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    171. pH-dependent fusion of phosphatidylcholine small vesicles. Induction by a synthetic amphipathic peptide. J Biol Chem. 1988 Apr 05; 263(10):4724-30. Parente RA, Nir S, Szoka FC. PMID: 2450874.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    172. Lecithin:cholesterol acyltransferase activation by synthetic amphipathic peptides. Proteins. 1988; 3(3):187-98. Subbarao NK, Fielding CJ, Hamilton RL, Szoka FC. PMID: 3255105.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    173. pH-dependent bilayer destabilization by an amphipathic peptide. Biochemistry. 1987 Jun 02; 26(11):2964-72. Subbarao NK, Parente RA, Szoka FC, Nadasdi L, Pongracz K. PMID: 2886149.
      View in: PubMed   Mentions: 57     Fields:    Translation:Cells
    174. Effect of size and lipid composition on the pharmacokinetics of intravitreal liposomes. Invest Ophthalmol Vis Sci. 1987 May; 28(5):893-900. Barza M, Stuart M, Szoka F. PMID: 3106257.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    175. Destabilization of phosphatidylethanolamine-containing liposomes: hexagonal phase and asymmetric membranes. Biochemistry. 1987 Apr 21; 26(8):2105-16. Bentz J, Ellens H, Szoka FC. PMID: 3620441.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    176. Modulation of the biological activity of bacterial endotoxin by incorporation into liposomes. J Immunol. 1987 Apr 15; 138(8):2663-70. Dijkstra J, Mellors JW, Ryan JL, Szoka FC. PMID: 3494081.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    177. Effect of lipid composition and liposome size on toxicity and in vitro fungicidal activity of liposome-intercalated amphotericin B. Antimicrob Agents Chemother. 1987 Mar; 31(3):421-9. Szoka FC, Milholland D, Barza M. PMID: 3579259; PMCID: PMC174744.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    178. Uptake of liposome-encapsulated agents. Methods Enzymol. 1987; 149:143-7. Szoka FC, Jones CS. PMID: 3121982.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    179. Fusion of phosphatidylethanolamine-containing liposomes and mechanism of the L alpha-HII phase transition. Biochemistry. 1986 Jul 15; 25(14):4141-7. Ellens H, Bentz J, Szoka FC. PMID: 3741846.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    180. Destabilization of phosphatidylethanolamine liposomes at the hexagonal phase transition temperature. Biochemistry. 1986 Jan 28; 25(2):285-94. Ellens H, Bentz J, Szoka FC. PMID: 3954998.
      View in: PubMed   Mentions: 29     Fields:    Translation:Cells
    181. On the correlation between HII phase and the contact-induced destabilization of phosphatidylethanolamine-containing membranes. Proc Natl Acad Sci U S A. 1985 Sep; 82(17):5742-5. Bentz J, Ellens H, Lai MZ, Szoka FC. PMID: 3862092; PMCID: PMC390628.
      View in: PubMed   Mentions: 11     Fields:    
    182. Ocular toxicity of intravitreally injected liposomal amphotericin B in rhesus monkeys. Am J Ophthalmol. 1985 Aug 15; 100(2):259-63. Barza M, Baum J, Tremblay C, Szoka F, D'Amico DJ. PMID: 4025467.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    183. H+- and Ca2+-induced fusion and destabilization of liposomes. Biochemistry. 1985 Jun 18; 24(13):3099-106. Ellens H, Bentz J, Szoka FC. PMID: 4027232.
      View in: PubMed   Mentions: 98     Fields:    Translation:Animals
    184. Reduced toxicity of liposome-associated amphotericin B injected intravitreally in rabbits. Invest Ophthalmol Vis Sci. 1985 May; 26(5):711-8. Tremblay C, Barza M, Szoka F, Lahav M, Baum J. PMID: 3997420.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    185. Effects of replacement of the hydroxyl group of cholesterol and tocopherol on the thermotropic behavior of phospholipid membranes. Biochemistry. 1985 Mar 26; 24(7):1646-53. Lai MZ, Düzgünes N, Szoka FC. PMID: 3839132.
      View in: PubMed   Mentions: 12     Fields:    
    186. Acid- and calcium-induced structural changes in phosphatidylethanolamine membranes stabilized by cholesteryl hemisuccinate. Biochemistry. 1985 Mar 26; 24(7):1654-61. Lai MZ, Vail WJ, Szoka FC. PMID: 4005220.
      View in: PubMed   Mentions: 16     Fields:    
    187. Efficacy of liposome-intercalated amphotericin B in the treatment of systemic candidiasis in mice. Antimicrob Agents Chemother. 1984 Aug; 26(2):170-3. Tremblay C, Barza M, Fiore C, Szoka F. PMID: 6385839; PMCID: PMC284113.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    188. Treatment of experimental cutaneous leishmaniasis with liposome-intercalated amphotericin B. Antimicrob Agents Chemother. 1984 May; 25(5):655-6. Panosian CB, Barza M, Szoka F, Wyler DJ. PMID: 6732232; PMCID: PMC185609.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    189. Pharmacokinetics of subconjunctival liposome-encapsulated gentamicin in normal rabbit eyes. Invest Ophthalmol Vis Sci. 1984 Apr; 25(4):486-90. Barza M, Baum J, Szoka F. PMID: 6706512.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    190. pH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact. Biochemistry. 1984 Mar 27; 23(7):1532-8. Ellens H, Bentz J, Szoka FC. PMID: 6722105.
      View in: PubMed   Mentions: 80     Fields:    
    191. Alteration of liposome disposition in vivo by bilayer situated carbohydrates. Biochem Biophys Res Commun. 1983 Jan 14; 110(1):140-6. Szoka FC, Mayhew E. PMID: 6687678.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    192. The use of a new radioactive-iodine labeled lipid marker to follow in vivo disposition of liposomes: comparison with an encapsulated aqueous space marker. Res Commun Chem Pathol Pharmacol. 1982 Aug; 37(2):199-213. Abra RM, Schreier H, Szoka FC. PMID: 7134628.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    193. Lectins as a probe for carbohydrate residues in non-neoplastic urothelium of human urinary bladder. J Urol. 1982 Jul; 128(1):189-93. Alroy J, Szoka FC, Heaney JA, Ucci AA. PMID: 6809959.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    194. Characterization, toxicity and therapeutic efficacy of adriamycin encapsulated in liposomes. Eur J Cancer Clin Oncol. 1982 Feb; 18(2):167-76. Olson F, Mayhew E, Maslow D, Rustum Y, Szoka F. PMID: 7201392.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    195. Sedimentation field flow fractionation of liposomes. Science. 1982 Jan 15; 215(4530):296-8. Kirkland JJ, Yau WW, Szoka FC. PMID: 7053578.
      View in: PubMed   Mentions: 4     Fields:    
    196. Inability of liposome encapsulated 1-beta-D-arabinofuranosylcytosine nucleotides to overcome drug resistance in L1210 cells. Eur J Cancer Clin Oncol. 1981 Jul; 17(7):809-17. Rustum YM, Mayhew E, Szoka F, Campbell J. PMID: 7199474.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    197. Use of lectins and polyethylene glycol for fusion of glycolipid-containing liposomes with eukaryotic cells. Proc Natl Acad Sci U S A. 1981 Mar; 78(3):1685-9. Szoka F, Magnusson KE, Wojcieszyn J, Hou Y, Derzko Z, Jacobson K. PMID: 6940182; PMCID: PMC319197.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    198. Preparation of unilamellar liposomes of intermediate size (0.1-0.2 mumol) by a combination of reverse phase evaporation and extrusion through polycarbonate membranes. Biochim Biophys Acta. 1980 Oct 02; 601(3):559-71. Szoka F, Olson F, Heath T, Vail W, Mayhew E, Papahadjopoulos D. PMID: 6251878.
      View in: PubMed   Mentions: 60     Fields:    Translation:Cells
    199. Fluorescence studies on the mechanism of liposome-cell interactions in vitro. Biochim Biophys Acta. 1980 Jul 16; 600(1):1-18. Szoka F, Jacobson K, Derzko Z, Papahadjopoulos D. PMID: 7397162.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    200. Comparative properties and methods of preparation of lipid vesicles (liposomes). Annu Rev Biophys Bioeng. 1980; 9:467-508. Szoka F, Papahadjopoulos D. PMID: 6994593.
      View in: PubMed   Mentions: 224     Fields:    
    201. Role of cholesterol in enhancing the antitumor activity of cytosine arabinoside entrapped in liposomes. Cancer Treat Rep. 1979 Nov-Dec; 63(11-12):1923-8. Mayhew E, Rustum YM, Szoka F, Papahadjopoulos D. PMID: 526925.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    202. Photoaffinity labeling of three renal cyclic 3',5'-adenosine monophosphate-binding proteins. Biochim Biophys Acta. 1979 Nov 01; 587(4):522-39. Near JA, Szoka FC, Olsen R, Ettinger MJ. PMID: 228750.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    203. Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes. Biochim Biophys Acta. 1979 Oct 19; 557(1):9-23. Olson F, Hunt CA, Szoka FC, Vail WJ, Papahadjopoulos D. PMID: 95096.
      View in: PubMed   Mentions: 155     Fields:    
    204. A model for the study of the oral administration of peptide hormones. Can J Biochem. 1979 Jun; 57(6):548-53. Saffran M, Franco-Saenz R, Kong A, Papahadjopoulos D, Szoka F. PMID: 314322.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    205. The use of aqueous space markers to determine the mechanism of interaction between phospholipid vesicles and cells. Biochim Biophys Acta. 1979 Mar 08; 551(2):295-303. Szoka FC, Jacobson K, Papahadjopoulos D. PMID: 420835.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    206. Lateral diffusion of a hydrophobic peptide, N-4-nitrobenz-2-oxa-1,3-diazole gramicidin S, in phospholipid multibilayers. Biochemistry. 1978 Dec 12; 17(25):5543-50. Wu ES, Jacobson K, Szoka F, Portis A. PMID: 83159.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    207. Adenosine 3' :5' -monophosphate-dependnet phosphorylations of renal subcellular fractions. Differences between cortical and medullary membrane preparations. J Biol Chem. 1978 Sep 25; 253(18):6536-43. Szoka FC, Ettinger MJ. PMID: 210188.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    208. Procedure for preparation of liposomes with large internal aqueous space and high capture by reverse-phase evaporation. Proc Natl Acad Sci U S A. 1978 Sep; 75(9):4194-8. Szoka F, Papahadjopoulos D. PMID: 279908; PMCID: PMC336078.
      View in: PubMed   Mentions: 369     Fields:    
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