Francis Szoka, PhD

Title(s)Professor, Bioengineering
SchoolSchool of Pharmacy
Address513 Parnassus Ave, HSE
San Francisco CA 94143
Phone415-476-4676
ORCID ORCID Icon0000-0002-6236-0621 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    1980Chancellor's Award for Academic Excellence, Universiy of California, San Francisco (with Dr. Richard
    1986Louis W. Busse Lecturer, University of Wisconsin. Madison, Wisconsin
    1990Fellow of the American Association of Pharmaceutical Sciences
    1994Paul Neumann Prize Lecture (with Dr. Jean-Yves Legendre)
    1995Glaxo Lecturer, University of North Carolina, School of Pharmacy. Chapel Hill, North Carolina
    1995Walter F. Enz Lecturer, University of Kansas. Lawrence, Kansas
    1995Keynote Speaker, Pharmaceutical Chemistry Asilomar Retreat, Asilomar, California
    1997Controlled Release Society, Jorge Heller Outstanding Paper Award, Journal of Controlled Release. Sh
    2000Honorary Doctorate in Pharmacy, University of Kuopio. Kuopio, Finland. (June)
    2000American Association of Colleges of Pharmacy- Paul Dawson
    2000Biotechnology Award (July)
    2001America Association of Pharmaceutical Scientists- Career ResearchAchievement Award in Biotechnology
    2006Tenth Alec Bangham Career Achievement Award for Outstanding Liposome Research Award
    2007UCSF Outstanding Faculty Mentorship Award
    2008University of North Carolina- GlaxoSmithKline Faculty Lecturer
    2011Dr. Rainer Hoffman Product Through Science Award.

    Collapse Overview 
    Collapse Overview
    The Szoka group applies chemical, biophysical and molecular biology approaches to devise vaccine, drug and nucleic acid delivery systems to treat cancer or infectious diseases. These systems can incorporate lipids, peptides, polymers and proteins. These drug carriers are composed of lipids, polymers, peptides or proteins. His group has extensively investigated the role of lipids in membrane fusion and his designed, synthesized and studied the mechanism of fusogenic peptides. With group members, he has published over 195 manuscripts and has received 26 U.S. patents. One FDA approved drug product Amphotec™ and one biotechnology product Superfect™ have been commercialized from the patents. In addition to his University commitments, Dr. Szoka is a founder of Sequus Pharmaceuticals, Inc. owned by Johnson & Johnson and GeneMedicine, inc. now known as Valentis, Inc. Sequus introduced sterically stabilized liposomes for anti-cancer drug delivery (Doxil™).

    Collapse Research 
    Collapse Research Activities and Funding
    Retargeting FDA Approved Anticancer Liposomal Drugs to Cancer Stem Cells
    NIH R41CA192689Apr 3, 2015 - Dec 31, 2016
    Role: Principal Investigator
    Syngeneic Macrophages for Personalized Cancer Therapy
    NIH R21CA182703Jan 1, 2014 - Dec 31, 2015
    Role: Principal Investigator
    Improving Protein Delivery and Circulation via FcRn Ligands
    NIH R21EB015520Jul 15, 2012 - Jun 30, 2014
    Role: Principal Investigator
    HIV neutralizing antibodies induced by chemically modified MPR epitopes
    NIH R21AI093135Aug 15, 2011 - Jul 31, 2013
    Role: Principal Investigator
    Carolina Center of Cancer Nanotechnology Excellence
    NIH U54CA119343Sep 30, 2005 - Aug 31, 2012
    Role: Co-Investigator
    Pharmacology of Targeted Therapy to Brain Tumors
    NIH R01CA107268Mar 1, 2004 - Feb 28, 2010
    Role: Principal Investigator
    Rational Design of Viral-Mimetic Lipid Gene Vectors
    NIH R01EB003008Sep 22, 2003 - Jun 30, 2015
    Role: Principal Investigator
    Biocompatible Dendritic Polymers for in vivo Applications
    NIH R01EB002047Apr 1, 2002 - Jul 31, 2011
    Role: Principal Investigator
    Biocompatible Dendritic Polymers : In Vivo Applications
    NIH R01GM065361Apr 1, 2002 - Mar 31, 2006
    Role: Principal Investigator
    Targeted Drug Delivery to Surface Receptors.
    NIH R01GM061851Jul 1, 2000 - Feb 28, 2017
    Role: Principal Investigator
    MOLECULAR BASIS OF DRUG TRANSPORT IN THE INTESTINE
    NIH R01GM057656Aug 1, 1997 - Jul 31, 2001
    Role: Co-Investigator
    GENE THERAPY CORE--CYSTIC FIBROSIS &NON-CF GENETIC DIS
    NIH P30DK047766Sep 30, 1993 - Aug 31, 1999
    Role: Co-Investigator
    SYNTHETIC GENE CARRIERS TO TREAT CYSTIC FIBROSIS
    NIH R01DK046052Sep 30, 1992 - Mar 31, 2003
    Role: Principal Investigator
    TARGETED CHEMOTHERAPY TO HIV INFECTED MACROPHAGES
    NIH R01AI025099Jul 1, 1989 - Dec 31, 1992
    Role: Principal Investigator
    CFTR AND AIRWAY PATHOLOGY OF CYSTIC FIBROSIS
    NIH P50HL042368Sep 30, 1988 - Aug 31, 1999
    Role: Co-Investigator
    Pharmaceutical Sciences and Pharmacogenomics
    NIH T32GM007175Jul 1, 1982 - Jun 30, 2022
    Role: Co-Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    CONTROLLED DISPOSITION OF LIPOSOMES
    NIH R01GM030163Feb 1, 1982 - Jun 30, 1996
    Role: Principal Investigator
    MICROINJECTION INTO CELLS BY A LIPOSOME SYSTEM
    NIH R01GM029514Apr 1, 1981 - Nov 30, 1987
    Role: Principal Investigator
    PHARMACOKINETICS/PHARMACODYNAMICS
    NIH P50GM026691Aug 1, 1979 - Jul 31, 1998
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Biophysical studies of HIV-1 glycoprotein-41 interactions with peptides and small molecules - Effect of lipids and detergents. Biochim Biophys Acta Gen Subj. 2020 12; 1864(12):129724. Zhou G, Chu S, Kohli A, Szoka FC, Gochin M. PMID: 32889078.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    2. Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency. Nat Biotechnol. 2020 01; 38(1):44-49. Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, Bluestone JA, Puck JM, Szoka FC, Marson A. PMID: 31819258.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    3. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature. 2019 08; 572(7771):614-619. Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. PMID: 31435015.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    4. Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition. PLoS One. 2019; 14(4):e0215218. Dolor A, Sampson SL, Lazar AA, Lotz JC, Szoka FC, Fields AJ. PMID: 30970007.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    5. Development of a flow-through USP 4 apparatus drug release assay for the evaluation of amphotericin B liposome. Eur J Pharm Biopharm. 2019 Jan; 134:107-116. Tang J, Srinivasan S, Yuan W, Ming R, Liu Y, Dai Z, Noble CO, Hayes ME, Zheng N, Jiang W, Szoka FC, Schwendeman A. PMID: 30481559.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    6. Correction: Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation. Chem Commun (Camb). 2018 11 13; 54(91):12891. Dolor A, Kierstead P, Dai Z, Szoka FC. PMID: 30387791.
      View in: PubMed   Mentions:    Fields:    
    7. Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation. Chem Commun (Camb). 2018 Oct 28; 54(84):11949-11952. Dolor A, Kierstead P, Dai Z, Szoka FC. PMID: 30288531.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    8. Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery. Mol Pharm. 2018 06 04; 15(6):2069-2083. Dolor A, Szoka FC. PMID: 29767984.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    9. Constrained Versus Free Cholesterol in DPPC Membranes: A Comparison of Chain Ordering Ability Using Deuterium NMR. Langmuir. 2017 12 19; 33(50):14405-14413. Shaghaghi M, Keyvanloo A, Huang Z, Szoka FC, Thewalt JL. PMID: 29120186.
      View in: PubMed   Mentions: 1     Fields:    
    10. Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice. Mol Ther Methods Clin Dev. 2017 Dec 15; 7:60-73. Lee S, Kivimäe S, Szoka FC. PMID: 29034260.
      View in: PubMed   Mentions:
    11. Biodistribution and In Vivo Antileishmanial Activity of 1,2-Distigmasterylhemisuccinoyl-sn-Glycero-3-Phosphocholine Liposome-Intercalated Amphotericin B. Antimicrob Agents Chemother. 2017 09; 61(9). Iman M, Huang Z, Alavizadeh SH, Szoka FC, Jaafari MR. PMID: 28630182.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    12. Encapsulation, controlled release, and antitumor efficacy of cisplatin delivered in liposomes composed of sterol-modified phospholipids. Eur J Pharm Sci. 2017 May 30; 103:85-93. Kieler-Ferguson HM, Chan D, Sockolosky J, Finney L, Maxey E, Vogt S, Szoka FC. PMID: 28263913.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. Co-localization of fluorescent labeled lipid nanoparticles with specifically tagged subcellular compartments by single particle tracking at low nanoparticle to cell ratios. J Drug Target. 2016 11; 24(9):857-864. Tiffany M, Szoka FC. PMID: 27600702.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Development of a Flow-Through USP-4 Apparatus Drug Release Assay to Evaluate Doxorubicin Liposomes. AAPS J. 2017 01; 19(1):150-160. Yuan W, Kuai R, Dai Z, Yuan Y, Zheng N, Jiang W, Noble C, Hayes M, Szoka FC, Schwendeman A. PMID: 27485642.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    15. Macrophage-based cell therapies: The long and winding road. J Control Release. 2016 10 28; 240:527-540. Lee S, Kivimäe S, Dolor A, Szoka FC. PMID: 27422609.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    16. The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes. J Control Release. 2015 Sep 10; 213:1-9. Kierstead PH, Okochi H, Venditto VJ, Chuong TC, Kivimae S, Fréchet JMJ, Szoka FC. PMID: 26093095.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    17. The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy. Adv Drug Deliv Rev. 2015 Aug 30; 91:109-24. Sockolosky JT, Szoka FC. PMID: 25703189.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    18. Sulfated quaternary amine lipids: a new class of inverse charge zwitterlipids. Chem Commun (Camb). 2014 Aug 21; 50(65):9109-11. Venditto VJ, Dolor A, Kohli A, Salentinig S, Boyd BJ, Szoka FC. PMID: 24984814.
      View in: PubMed   Mentions: 2     Fields:    
    19. Fusion of a short peptide that binds immunoglobulin G to a recombinant protein substantially increases its plasma half-life in mice. PLoS One. 2014; 9(7):e102566. Sockolosky JT, Kivimäe S, Szoka FC. PMID: 25057984.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    20. Chemically modified peptides based on the membrane-proximal external region of the HIV-1 envelope induce high-titer, epitope-specific nonneutralizing antibodies in rabbits. Clin Vaccine Immunol. 2014 Aug; 21(8):1086-93. Venditto VJ, Wieczorek L, Molnar S, Teque F, Landucci G, Watson DS, Forthal D, Polonis VR, Levy JA, Szoka FC. PMID: 24872518.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    21. Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronan. J Control Release. 2014 Oct 10; 191:105-14. Kohli AG, Kivimäe S, Tiffany MR, Szoka FC. PMID: 24852095.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    22. Designer lipids for drug delivery: from heads to tails. J Control Release. 2014 Sep 28; 190:274-87. Kohli AG, Kierstead PH, Venditto VJ, Walsh CL, Szoka FC. PMID: 24816069.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    23. Chemoenzymatic synthesis of oligohyaluronan-lipid conjugates. Bioconjug Chem. 2014 Apr 16; 25(4):718-23. Ruhela D, Kivimäe S, Szoka FC. PMID: 24646444.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    24. A robust and quantitative method for tracking liposome contents after intravenous administration. J Control Release. 2014 Feb 28; 176:86-93. Kohli AG, Kieler-Ferguson HM, Chan D, Szoka FC. PMID: 24368300.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    25. Novel ortho ester-based, pH-sensitive cationic lipid for gene delivery in vitro and in vivo. J Liposome Res. 2014 Jun; 24(2):90-8. Guo X, Gagne L, Chen H, Szoka FC. PMID: 24188532.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    26. Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease. PLoS One. 2013; 8(2):e56026. Li M, Yasumura D, Ma AA, Matthes MT, Yang H, Nielson G, Huang Y, Szoka FC, Lavail MM, Diamond MI. PMID: 23409115.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    27. Clinical developments of chemotherapeutic nanomedicines: polymers and liposomes for delivery of camptothecins and platinum (II) drugs. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Mar-Apr; 5(2):130-8. Kieler-Ferguson HM, Fréchet JM, Szoka FC. PMID: 23335566.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    28. Synthesis, characterization, and evaluation of ionizable lysine-based lipids for siRNA delivery. Bioconjug Chem. 2013 Jan 16; 24(1):36-43. Walsh CL, Nguyen J, Tiffany MR, Szoka FC. PMID: 23176544.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Periplasmic production via the pET expression system of soluble, bioactive human growth hormone. Protein Expr Purif. 2013 Feb; 87(2):129-35. Sockolosky JT, Szoka FC. PMID: 23168094.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    30. Rational design of membrane proximal external region lipopeptides containing chemical modifications for HIV-1 vaccination. Clin Vaccine Immunol. 2013 Jan; 20(1):39-45. Venditto VJ, Watson DS, Motion M, Montefiori D, Szoka FC. PMID: 23114698.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsPHPublic Health
    31. Cancer nanomedicines: so many papers and so few drugs! Adv Drug Deliv Rev. 2013 Jan; 65(1):80-8. Venditto VJ, Szoka FC. PMID: 23036224.
      View in: PubMed   Mentions: 103     Fields:    Translation:Humans
    32. Engineering neonatal Fc receptor-mediated recycling and transcytosis in recombinant proteins by short terminal peptide extensions. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16095-100. Sockolosky JT, Tiffany MR, Szoka FC. PMID: 22991460.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    33. Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds. Angew Chem Int Ed Engl. 2012 Sep 03; 51(36):9047-51. Motion JP, Nguyen J, Szoka FC. PMID: 22887437.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    34. Controlled nucleation of lipid nanoparticles. Pharm Res. 2012 Aug; 29(8):2236-48. Nguyen J, Walsh CL, Motion JP, Perttu EK, Szoka F. PMID: 22544683.
      View in: PubMed   Mentions: 4     Fields:    
    35. Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties. Chem Commun (Camb). 2012 Jun 07; 48(45):5575-7. Walsh CL, Nguyen J, Szoka FC. PMID: 22538384.
      View in: PubMed   Mentions: 11     Fields:    
    36. Nucleic acid delivery: the missing pieces of the puzzle? Acc Chem Res. 2012 Jul 17; 45(7):1153-62. Nguyen J, Szoka FC. PMID: 22428908.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    37. Inverse-phosphocholine lipids: a remix of a common phospholipid. J Am Chem Soc. 2012 Mar 14; 134(10):4485-8. Perttu EK, Kohli AG, Szoka FC. PMID: 22364493.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    38. Synthesis and characterization of betaine-like diacyl lipids: zwitterionic lipids with the cationic amine at the bilayer interface. Chem Phys Lipids. 2012 Feb; 165(2):252-9. Kohli AG, Walsh CL, Szoka FC. PMID: 22301334.
      View in: PubMed   Mentions: 4     Fields:    
    39. Zwitterionic sulfobetaine lipids that form vesicles with salt-dependent thermotropic properties. Chem Commun (Camb). 2011 Dec 21; 47(47):12613-5. Perttu EK, Szoka FC. PMID: 22045250.
      View in: PubMed   Mentions: 6     Fields:    
    40. Asymmetric 1-alkyl-2-acyl phosphatidylcholine: a helper lipid for enhanced non-viral gene delivery. Int J Pharm. 2012 May 01; 427(1):64-70. Huang Z, Li W, Szoka FC. PMID: 21718766.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    41. Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecan. J Control Release. 2011 Aug 10; 153(3):288-96. Riviere K, Kieler-Ferguson HM, Jerger K, Szoka FC. PMID: 21600250.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    42. Synthesis and properties of star-comb polymers and their doxorubicin conjugates. Bioconjug Chem. 2011 Apr 20; 22(4):617-24. Chen B, van der Poll DG, Jerger K, Floyd WC, Fréchet JM, Szoka FC. PMID: 21375296.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    43. Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion. Phys Chem Chem Phys. 2011 Mar 28; 13(12):5346-52. Guy RH, Szoka FC. PMID: 21286598.
      View in: PubMed   Mentions: 1     Fields:    
    44. Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a di-stigma-steryl-hemi-succinoyl-glycero-phosphocholine liposome-intercalated amphotericin B. Int J Pharm. 2011 Apr 15; 408(1-2):163-72. Iman M, Huang Z, Szoka FC, Jaafari MR. PMID: 21277963.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    45. Chemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in c26 tumor bearing mice. ChemMedChem. 2011 Jan 03; 6(1):49-53. Floyd WC, Datta GK, Imamura S, Kieler-Ferguson HM, Jerger K, Patterson AW, Fox ME, Szoka FC, Fréchet JM, Ellman JA. PMID: 20973119.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    46. Antibody response to polyhistidine-tagged peptide and protein antigens attached to liposomes via lipid-linked nitrilotriacetic acid in mice. Clin Vaccine Immunol. 2011 Feb; 18(2):289-97. Watson DS, Platt VM, Cao L, Venditto VJ, Szoka FC. PMID: 21159923.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    47. Convection and retro-convection enhanced delivery: some theoretical considerations related to drug targeting. Pharm Res. 2011 Mar; 28(3):472-9. Motion JP, Huynh GH, Szoka FC, Siegel RA. PMID: 20963628.
      View in: PubMed   Mentions: 3     Fields:    
    48. Influence of multivalent nitrilotriacetic acid lipid-ligand affinity on the circulation half-life in mice of a liposome-attached His6-protein. Bioconjug Chem. 2010 May 19; 21(5):892-902. Platt V, Huang Z, Cao L, Tiffany M, Riviere K, Szoka FC. PMID: 20384362.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    49. Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer. Bioconjug Chem. 2010 Apr 21; 21(4):764-73. van der Poll DG, Kieler-Ferguson HM, Floyd WC, Guillaudeu SJ, Jerger K, Szoka FC, Fréchet JM. PMID: 20353169.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    50. Antitumor effect of folate-targeted liposomal doxorubicin in KB tumor-bearing mice after intravenous administration. J Drug Target. 2011 Jan; 19(1):14-24. Riviere K, Huang Z, Jerger K, Macaraeg N, Szoka FC. PMID: 20353291.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    51. Utilizing the O-antigen lipopolysaccharide biosynthesis pathway in Escherichia coli to interrogate the substrate specificities of exogenous glycosyltransferase genes in a combinatorial approach. Glycobiology. 2010 Jun; 20(6):763-74. Johansen EB, Szoka FC, Zaleski A, Apicella MA, Gibson BW. PMID: 20208062.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    52. Synthesis and in vivo antitumor efficacy of PEGylated poly(l-lysine) dendrimer-camptothecin conjugates. Mol Pharm. 2009 Sep-Oct; 6(5):1562-72. Fox ME, Guillaudeu S, Fréchet JM, Jerger K, Macaraeg N, Szoka FC. PMID: 19588994.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    53. Soluble polymer carriers for the treatment of cancer: the importance of molecular architecture. Acc Chem Res. 2009 Aug 18; 42(8):1141-51. Fox ME, Szoka FC, Fréchet JM. PMID: 19555070.
      View in: PubMed   Mentions: 112     Fields:    Translation:Cells
    54. Tris-nitrilotriacetic acids of subnanomolar affinity toward hexahistidine tagged molecules. Bioconjug Chem. 2009 Aug 19; 20(8):1667-72. Huang Z, Hwang P, Watson DS, Cao L, Szoka FC. PMID: 19650657.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    55. All-trans retinoic acid potentiates the antibody response in mice to a lipopeptide antigen adjuvanted with liposomal lipid A. Immunol Cell Biol. 2009 Nov-Dec; 87(8):630-3. Watson DS, Huang Z, Szoka FC. PMID: 19597529.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    56. Role of lipid structure in the humoral immune response in mice to covalent lipid-peptides from the membrane proximal region of HIV-1 gp41. Vaccine. 2009 Jul 23; 27(34):4672-83. Watson DS, Szoka FC. PMID: 19520200.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    57. The influence of polymer topology on pharmacokinetics: differences between cyclic and linear PEGylated poly(acrylic acid) comb polymers. J Control Release. 2009 Dec 16; 140(3):203-9. Chen B, Jerger K, Fréchet JM, Szoka FC. PMID: 19465070.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    58. Antitumor therapy mediated by 5-fluorocytosine and a recombinant fusion protein containing TSG-6 hyaluronan binding domain and yeast cytosine deaminase. Mol Pharm. 2009 May-Jun; 6(3):801-12. Park JI, Cao L, Platt VM, Huang Z, Stull RA, Dy EE, Sperinde JJ, Yokoyama JS, Szoka FC. PMID: 19265397.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    59. Dependence of pharmacokinetics and biodistribution on polymer architecture: effect of cyclic versus linear polymers. J Am Chem Soc. 2009 Mar 25; 131(11):3842-3. Nasongkla N, Chen B, Macaraeg N, Fox ME, Fréchet JM, Szoka FC. PMID: 19256497.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    60. Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection. J Control Release. 2009 Apr 17; 135(2):166-74. Cohen RN, van der Aa MA, Macaraeg N, Lee AP, Szoka FC. PMID: 19211029.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    61. Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery. Angew Chem Int Ed Engl. 2009; 48(23):4146-9. Huang Z, Jaafari MR, Szoka FC. PMID: 19425026.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    62. Sterol-modified phospholipids: cholesterol and phospholipid chimeras with improved biomembrane properties. J Am Chem Soc. 2008 Nov 19; 130(46):15702-12. Huang Z, Szoka FC. PMID: 18950160.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    63. Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor. Mol Pharm. 2008 Jul-Aug; 5(4):474-86. Platt VM, Szoka FC. PMID: 18547053.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimals
    64. HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced delivery. Mol Ther. 2008 May; 16(5):893-900. MacKay JA, Li W, Huang Z, Dy EE, Huynh G, Tihan T, Collins R, Deen DF, Szoka FC. PMID: 18388927.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    65. Molecular biology. The art of assembly. Science. 2008 Feb 01; 319(5863):578-9. Szoka F. PMID: 18239114.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    66. PEGylated dendrimers with core functionality for biological applications. Bioconjug Chem. 2008 Feb; 19(2):461-9. Guillaudeu SJ, Fox ME, Haidar YM, Dy EE, Szoka FC, Fréchet JM. PMID: 18173227.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    67. Unsaturated cationic ortho esters for endosome permeation in gene delivery. J Med Chem. 2007 Sep 06; 50(18):4269-78. Chen H, Zhang H, McCallum CM, Szoka FC, Guo X. PMID: 17691717.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    68. Reconstitution of the M13 major coat protein and its transmembrane peptide segment on a DNA template. Biochemistry. 2007 Jul 24; 46(29):8579-91. Li W, Suez I, Szoka FC. PMID: 17595059.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    69. Lipid-based nanoparticles for nucleic acid delivery. Pharm Res. 2007 Mar; 24(3):438-49. Li W, Szoka FC. PMID: 17252188.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimals
    70. Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells. Mol Med. 2007 Mar-Apr; 13(3-4):190-8. Karpuj MV, Giles K, Gelibter-Niv S, Scott MR, Lingappa VR, Szoka FC, Peretz D, Denetclaw W, Prusiner SB. PMID: 17592554.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    71. Retro-convection enhanced delivery to increase blood to brain transfer of macromolecules. Brain Res. 2007 Jan 12; 1128(1):181-90. Huynh GH, Ozawa T, Deen DF, Tihan T, Szoka FC. PMID: 17125752.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    72. Facile synthesis of multivalent nitrilotriacetic acid (NTA) and NTA conjugates for analytical and drug delivery applications. Bioconjug Chem. 2006 Nov-Dec; 17(6):1592-600. Huang Z, Park JI, Watson DS, Hwang P, Szoka FC. PMID: 17105240.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    73. A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16649-54. Lee CC, Gillies ER, Fox ME, Guillaudeu SJ, Fréchet JM, Dy EE, Szoka FC. PMID: 17075050.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    74. Efficient synthesis of an aldehyde functionalized hyaluronic acid and its application in the preparation of hyaluronan-lipid conjugates. Bioconjug Chem. 2006 Sep-Oct; 17(5):1360-3. Ruhela D, Riviere K, Szoka FC. PMID: 16984148.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    75. An intramolecular cyclization reaction is responsible for the in vivo inefficacy and apparent pH insensitive hydrolysis kinetics of hydrazone carboxylate derivatives of doxorubicin. Bioconjug Chem. 2006 Sep-Oct; 17(5):1364-8. Lee CC, Cramer AT, Szoka FC, Fréchet JM. PMID: 16984149.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    76. Bioresponsive targeted charge neutral lipid vesicles for systemic gene delivery. CSH Protoc. 2006 Jun 01; 2006(1). Li W, Szoka FC. PMID: 22485781.
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    77. Acid-triggered transformation of diortho ester phosphocholine liposome. J Am Chem Soc. 2006 Jan 11; 128(1):60-1. Huang Z, Guo X, Li W, MacKay JA, Szoka FC. PMID: 16390121.
      View in: PubMed   Mentions: 11     Fields:    
    78. Designing dendrimers for biological applications. Nat Biotechnol. 2005 Dec; 23(12):1517-26. Lee CC, MacKay JA, Fréchet JM, Szoka FC. PMID: 16333296.
      View in: PubMed   Mentions: 312     Fields:    
    79. Barriers to carrier mediated drug and gene delivery to brain tumors. J Control Release. 2006 Jan 10; 110(2):236-259. Huynh GH, Deen DF, Szoka FC. PMID: 16318895.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    80. In vitro and in vivo evaluation of hydrophilic dendronized linear polymers. Bioconjug Chem. 2005 May-Jun; 16(3):535-41. Lee CC, Yoshida M, Fréchet JM, Dy EE, Szoka FC. PMID: 15898719.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    81. Biological evaluation of polyester dendrimer: poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture. Mol Pharm. 2005 Mar-Apr; 2(2):129-38. Gillies ER, Dy E, Fréchet JM, Szoka FC. PMID: 15804187.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    82. Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers. Mol Ther. 2005 Mar; 11(3):409-17. Huang Z, Li W, MacKay JA, Szoka FC. PMID: 15727937.
      View in: PubMed   Mentions: 12     Fields:    
    83. Toroid formation in charge neutralized flexible or semi-flexible biopolymers: potential pathway for assembly of DNA carriers. J Gene Med. 2005 Mar; 7(3):334-42. Tang MX, Li W, Szoka FC. PMID: 15515145.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    84. Identification of a deoxyribonuclease I inhibitor from a phage-peptide library. Mol Cells. 2005 Feb 28; 19(1):54-9. Choi SJ, Sperinde JJ, Szoka FC. PMID: 15750340.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    85. Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating. Brain Res. 2005 Feb 28; 1035(2):139-53. MacKay JA, Deen DF, Szoka FC. PMID: 15722054.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    86. Molecular motors as drug delivery vehicles. Drug Discov Today Technol. 2005; 2(1):111-8. Cohen RN, Rashkin MJ, Wen X, Szoka FC. PMID: 24981763.
      View in: PubMed   Mentions: 3     Fields:    
    87. Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery. J Gene Med. 2005 Jan; 7(1):67-79. Li W, Huang Z, MacKay JA, Grube S, Szoka FC. PMID: 15515149.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    88. GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery. Adv Drug Deliv Rev. 2004 Apr 23; 56(7):967-85. Li W, Nicol F, Szoka FC. PMID: 15066755.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    89. Determination and modeling of kinetics of cancer cell killing by doxorubicin and doxorubicin encapsulated in targeted liposomes. Cancer Res. 2004 Jan 15; 64(2):711-8. Eliaz RE, Nir S, Marty C, Szoka FC. PMID: 14744789.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    90. Interactions of hyaluronan-targeted liposomes with cultured cells: modeling of binding and endocytosis. Methods Enzymol. 2004; 387:16-33. Eliaz RE, Nir S, Szoka FC. PMID: 15172155.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    91. Improved preparation of PEG-diortho ester-diacyl glycerol conjugates. Methods Enzymol. 2004; 387:147-52. Guo X, Huang Z, Szoka FC. PMID: 15172162.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    92. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem. 2003 Nov 07; 278(45):44826-31. Sonawane ND, Szoka FC, Verkman AS. PMID: 12944394.
      View in: PubMed   Mentions: 225     Fields:    Translation:AnimalsCells
    93. Chemical approaches to triggerable lipid vesicles for drug and gene delivery. Acc Chem Res. 2003 May; 36(5):335-41. Guo X, Szoka FC. PMID: 12755643.
      View in: PubMed   Mentions: 60     Fields:    Translation:Cells
    94. Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid. Biophys J. 2003 Mar; 84(3):1784-95. Guo X, MacKay JA, Szoka FC. PMID: 12609880.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    95. Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization. Bioconjug Chem. 2003 Mar-Apr; 14(2):420-9. Choi JS, MacKay JA, Szoka FC. PMID: 12643753.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    96. Development of a high throughput Pseudomonas aeruginosa epithelial cell adhesion assay. J Microbiol Methods. 2003 Mar; 52(3):361-6. Swanson B, Savel R, Szoka F, Sawa T, Wiener-Kronish J. PMID: 12531505.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    97. HIV TAT Protein Transduction Domain Mediated Cell Binding and Intracellular Delivery of Nanoparticles. J Dispers Sci Technol. 2003; 24(3):465-473. Mackay JA, Szoka FC. PMID: 20808712.
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    98. Synthesis of vesicles on polymer template. J Am Chem Soc. 2002 Oct 09; 124(40):11872-3. Bronich TK, Ouyang M, Kabanov VA, Eisenberg A, Szoka FC, Kabanov AV. PMID: 12358530.
      View in: PubMed   Mentions: 6     Fields:    
    99. Polyester dendritic systems for drug delivery applications: design, synthesis, and characterization. Bioconjug Chem. 2002 May-Jun; 13(3):443-52. Ihre HR, Padilla De Jesús OL, Szoka FC, Fréchet JM. PMID: 12009932.
      View in: PubMed   Mentions: 27     Fields:    
    100. Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation. Bioconjug Chem. 2002 May-Jun; 13(3):453-61. Padilla De Jesús OL, Ihre HR, Gagne L, Fréchet JM, Szoka FC. PMID: 12009933.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    101. Simple mixing device to reproducibly prepare cationic lipid-DNA complexes (lipoplexes). Biotechniques. 1999 Aug; 27(2):286-90. Hirota S, de Ilarduya CT, Barron LG, Szoka FC. PMID: 10457833.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    102. Nomenclature for synthetic gene delivery systems. Hum Gene Ther. 1997 Mar 20; 8(5):511-2. Felgner PL, Barenholz Y, Behr JP, Cheng SH, Cullis P, Huang L, Jessee JA, Seymour L, Szoka F, Thierry AR, Wagner E, Wu G. PMID: 9095402.
      View in: PubMed   Mentions: 59     Fields:    
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