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Francis Szoka, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentBioengineering
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-3895
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    Collapse Biography 
    Collapse Awards and Honors
    1980Chancellor's Award for Academic Excellence, Universiy of California, San Francisco (with Dr. Richard
    1986Louis W. Busse Lecturer, University of Wisconsin. Madison, Wisconsin
    1990Fellow of the American Association of Pharmaceutical Sciences
    1994Paul Neumann Prize Lecture (with Dr. Jean-Yves Legendre)
    1995Glaxo Lecturer, University of North Carolina, School of Pharmacy. Chapel Hill, North Carolina
    1995Walter F. Enz Lecturer, University of Kansas. Lawrence, Kansas
    1995Keynote Speaker, Pharmaceutical Chemistry Asilomar Retreat, Asilomar, California
    1997Controlled Release Society, Jorge Heller Outstanding Paper Award, Journal of Controlled Release. Sh
    2000Honorary Doctorate in Pharmacy, University of Kuopio. Kuopio, Finland. (June)
    2000American Association of Colleges of Pharmacy- Paul Dawson
    2000Biotechnology Award (July)
    2001America Association of Pharmaceutical Scientists- Career ResearchAchievement Award in Biotechnology
    2006Tenth Alec Bangham Career Achievement Award for Outstanding Liposome Research Award
    2007UCSF Outstanding Faculty Mentorship Award
    2008University of North Carolina- GlaxoSmithKline Faculty Lecturer
    2011Dr. Rainer Hoffman Product Through Science Award.

    Collapse Overview 
    Collapse Overview
    The Szoka group applies chemical, biophysical and molecular biology approaches to devise vaccine, drug and nucleic acid delivery systems to treat cancer or infectious diseases. These systems can incorporate lipids, peptides, polymers and proteins. These drug carriers are composed of lipids, polymers, peptides or proteins. His group has extensively investigated the role of lipids in membrane fusion and his designed, synthesized and studied the mechanism of fusogenic peptides. With group members, he has published over 195 manuscripts and has received 26 U.S. patents. One FDA approved drug product Amphotec™ and one biotechnology product Superfect™ have been commercialized from the patents. In addition to his University commitments, Dr. Szoka is a founder of Sequus Pharmaceuticals, Inc. owned by Johnson & Johnson and GeneMedicine, inc. now known as Valentis, Inc. Sequus introduced sterically stabilized liposomes for anti-cancer drug delivery (Doxil™).


    Collapse Research 
    Collapse Research Activities and Funding
    Retargeting FDA Approved Anticancer Liposomal Drugs to Cancer Stem Cells
    NIH/NCI R41CA192689Apr 3, 2015 - Dec 31, 2015
    Role: Principal Investigator
    Syngeneic Macrophages for Personalized Cancer Therapy
    NIH/NCI R21CA182703Jan 1, 2014 - Dec 31, 2015
    Role: Principal Investigator
    Improving Protein Delivery and Circulation via FcRn Ligands
    NIH/NIBIB R21EB015520Jul 15, 2012 - Jun 30, 2014
    Role: Principal Investigator
    HIV neutralizing antibodies induced by chemically modified MPR epitopes
    NIH/NIAID R21AI093135Aug 15, 2011 - Jul 31, 2013
    Role: Principal Investigator
    Carolina Center of Cancer Nanotechnology Excellence
    NIH U54CA119343Sep 30, 2005 - Aug 31, 2012
    Role: Co-Investigator
    Pharmacology of Targeted Therapy to Brain Tumors
    NIH/NCI R01CA107268Mar 1, 2004 - Feb 28, 2010
    Role: Principal Investigator
    Rational Design of Viral-Mimetic Lipid Gene Vectors
    NIH/NIBIB R01EB003008Sep 22, 2003 - Jun 30, 2014
    Role: Principal Investigator
    Biocompatible Dendritic Polymers for in vivo Applications
    NIH/NIBIB R01EB002047Apr 1, 2002 - Jul 31, 2011
    Role: Principal Investigator
    Biocompatible Dendritic Polymers : In Vivo Applications
    NIH/NIGMS R01GM065361Apr 1, 2002 - Mar 31, 2006
    Role: Principal Investigator
    Targeted Drug Delivery to Surface Receptors.
    NIH/NIGMS R01GM061851Jul 1, 2000 - Feb 29, 2016
    Role: Principal Investigator
    MOLECULAR BASIS OF DRUG TRANSPORT IN THE INTESTINE
    NIH/NIGMS R01GM057656Aug 1, 1997 - Jul 31, 2001
    Role: Co-Investigator
    GENE THERAPY CORE--CYSTIC FIBROSIS &NON-CF GENETIC DIS
    NIH/NIDDK P30DK047766Sep 30, 1993 - Aug 31, 1999
    Role: Co-Investigator
    SYNTHETIC GENE CARRIERS TO TREAT CYSTIC FIBROSIS
    NIH/NIDDK R01DK046052Sep 30, 1992 - Mar 31, 2003
    Role: Principal Investigator
    TARGETED CHEMOTHERAPY TO HIV INFECTED MACROPHAGES
    NIH/NIAID R01AI025099Jul 1, 1989 - Dec 31, 1992
    Role: Principal Investigator
    CFTR AND AIRWAY PATHOLOGY OF CYSTIC FIBROSIS
    NIH P50HL042368Sep 30, 1988 - Aug 31, 1999
    Role: Co-Investigator
    Pharmaceutical Sciences and Pharmacogenomics
    NIH/NIGMS T32GM007175Jul 1, 1982 - Jun 30, 2022
    Role: Co-Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator
    CONTROLLED DISPOSITION OF LIPOSOMES
    NIH/NIGMS R01GM030163Feb 1, 1982 - Jun 30, 1996
    Role: Principal Investigator
    MICROINJECTION INTO CELLS BY A LIPOSOME SYSTEM
    NIH/NIGMS R01GM029514Apr 1, 1981 - Nov 30, 1987
    Role: Principal Investigator
    PHARMACOKINETICS/PHARMACODYNAMICS
    NIH/NIGMS P50GM026691Aug 1, 1979 - Jul 31, 1998
    Role: Co-Investigator
    Resource for Biocomputing, Visualization, and Informatics
    NIH/NCRR P41RR001081Jun 1, 1976 - Sep 14, 2012
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Tang J, Srinivasan S, Yuan W, Ming R, Liu Y, Dai Z, Noble CO, Hayes ME, Zheng N, Jiang W, Szoka FC, Schwendeman A. Development of a flow-through USP 4 apparatus drug release assay for the evaluation of amphotericin B liposome. Eur J Pharm Biopharm. 2018 Nov 24. PMID: 30481559.
      View in: PubMed
    2. Dolor A, Kierstead P, Dai Z, Szoka FC. Correction: Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation. Chem Commun (Camb). 2018 Nov 02. PMID: 30387791.
      View in: PubMed
    3. Dolor A, Kierstead P, Dai Z, Szoka FC. Sterol-modified PEG lipids: alteration of the bilayer anchoring moiety has an unexpected effect on liposome circulation. Chem Commun (Camb). 2018 Oct 05. PMID: 30288531.
      View in: PubMed
    4. Dolor A, Szoka FC. Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery. Mol Pharm. 2018 May 16. PMID: 29767984.
      View in: PubMed
    5. Shaghaghi M, Keyvanloo A, Huang Z, Szoka FC, Thewalt JL. Constrained Versus Free Cholesterol in DPPC Membranes: A Comparison of Chain Ordering Ability Using Deuterium NMR. Langmuir. 2017 Dec 19; 33(50):14405-14413. PMID: 29120186.
      View in: PubMed
    6. Lee S, Kivimäe S, Szoka FC. Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice. Mol Ther Methods Clin Dev. 2017 Dec 15; 7:60-73. PMID: 29034260.
      View in: PubMed
    7. Iman M, Huang Z, Alavizadeh SH, Szoka FC, Jaafari MR. Biodistribution and In Vivo Antileishmanial Activity of 1,2-Distigmasterylhemisuccinoyl-sn-Glycero-3-Phosphocholine Liposome-Intercalated Amphotericin B. Antimicrob Agents Chemother. 2017 Sep; 61(9). PMID: 28630182.
      View in: PubMed
    8. Kieler-Ferguson HM, Chan D, Sockolosky J, Finney L, Maxey E, Vogt S, Szoka FC. Encapsulation, controlled release, and antitumor efficacy of cisplatin delivered in liposomes composed of sterol-modified phospholipids. Eur J Pharm Sci. 2017 May 30; 103:85-93. PMID: 28263913.
      View in: PubMed
    9. Tiffany M, Szoka FC. Co-localization of fluorescent labeled lipid nanoparticles with specifically tagged subcellular compartments by single particle tracking at low nanoparticle to cell ratios. J Drug Target. 2016 Nov; 24(9):857-864. PMID: 27600702.
      View in: PubMed
    10. Yuan W, Kuai R, Dai Z, Yuan Y, Zheng N, Jiang W, Noble C, Hayes M, Szoka FC, Schwendeman A. Development of a Flow-Through USP-4 Apparatus Drug Release Assay to Evaluate Doxorubicin Liposomes. AAPS J. 2017 01; 19(1):150-160. PMID: 27485642.
      View in: PubMed
    11. Lee S, Kivimäe S, Dolor A, Szoka FC. Macrophage-based cell therapies: The long and winding road. J Control Release. 2016 10 28; 240:527-540. PMID: 27422609.
      View in: PubMed
    12. Kierstead PH, Okochi H, Venditto VJ, Chuong TC, Kivimae S, Fréchet JMJ, Szoka FC. The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes. J Control Release. 2015 Sep 10; 213:1-9. PMID: 26093095; PMCID: PMC4684485.
    13. Sockolosky JT, Szoka FC. The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy. Adv Drug Deliv Rev. 2015 Aug 30; 91:109-24. PMID: 25703189; PMCID: PMC4544678.
    14. Venditto VJ, Dolor A, Kohli A, Salentinig S, Boyd BJ, Szoka FC. Sulfated quaternary amine lipids: a new class of inverse charge zwitterlipids. Chem Commun (Camb). 2014 Aug 21; 50(65):9109-11. PMID: 24984814; PMCID: PMC4214375.
    15. Sockolosky JT, Kivimäe S, Szoka FC. Fusion of a short peptide that binds immunoglobulin G to a recombinant protein substantially increases its plasma half-life in mice. PLoS One. 2014; 9(7):e102566. PMID: 25057984; PMCID: PMC4109916.
    16. Venditto VJ, Wieczorek L, Molnar S, Teque F, Landucci G, Watson DS, Forthal D, Polonis VR, Levy JA, Szoka FC. Chemically modified peptides based on the membrane-proximal external region of the HIV-1 envelope induce high-titer, epitope-specific nonneutralizing antibodies in rabbits. Clin Vaccine Immunol. 2014 Aug; 21(8):1086-93. PMID: 24872518; PMCID: PMC4135905.
    17. Kohli AG, Kivimäe S, Tiffany MR, Szoka FC. Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronan. J Control Release. 2014 Oct 10; 191:105-14. PMID: 24852095; PMCID: PMC4156903.
    18. Kohli AG, Kierstead PH, Venditto VJ, Walsh CL, Szoka FC. Designer lipids for drug delivery: from heads to tails. J Control Release. 2014 Sep 28; 190:274-87. PMID: 24816069; PMCID: PMC4142081.
    19. Ruhela D, Kivimäe S, Szoka FC. Chemoenzymatic synthesis of oligohyaluronan-lipid conjugates. Bioconjug Chem. 2014 Apr 16; 25(4):718-23. PMID: 24646444; PMCID: PMC3993934.
    20. Kohli AG, Kieler-Ferguson HM, Chan D, Szoka FC. A robust and quantitative method for tracking liposome contents after intravenous administration. J Control Release. 2014 Feb 28; 176:86-93. PMID: 24368300.
      View in: PubMed
    21. Guo X, Gagne L, Chen H, Szoka FC. Novel ortho ester-based, pH-sensitive cationic lipid for gene delivery in vitro and in vivo. J Liposome Res. 2014 Jun; 24(2):90-8. PMID: 24188532.
      View in: PubMed
    22. Li M, Yasumura D, Ma AA, Matthes MT, Yang H, Nielson G, Huang Y, Szoka FC, Lavail MM, Diamond MI. Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease. PLoS One. 2013; 8(2):e56026. PMID: 23409115; PMCID: PMC3569418.
    23. Kieler-Ferguson HM, Fréchet JM, Szoka FC. Clinical developments of chemotherapeutic nanomedicines: polymers and liposomes for delivery of camptothecins and platinum (II) drugs. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Mar-Apr; 5(2):130-8. PMID: 23335566.
      View in: PubMed
    24. Walsh CL, Nguyen J, Tiffany MR, Szoka FC. Synthesis, characterization, and evaluation of ionizable lysine-based lipids for siRNA delivery. Bioconjug Chem. 2013 Jan 16; 24(1):36-43. PMID: 23176544; PMCID: PMC3586539.
    25. Sockolosky JT, Szoka FC. Periplasmic production via the pET expression system of soluble, bioactive human growth hormone. Protein Expr Purif. 2013 Feb; 87(2):129-35. PMID: 23168094; PMCID: PMC3537859.
    26. Venditto VJ, Watson DS, Motion M, Montefiori D, Szoka FC. Rational design of membrane proximal external region lipopeptides containing chemical modifications for HIV-1 vaccination. Clin Vaccine Immunol. 2013 Jan; 20(1):39-45. PMID: 23114698; PMCID: PMC3535774.
    27. Venditto VJ, Szoka FC. Cancer nanomedicines: so many papers and so few drugs! Adv Drug Deliv Rev. 2013 Jan; 65(1):80-8. PMID: 23036224; PMCID: PMC3565003.
    28. Sockolosky JT, Tiffany MR, Szoka FC. Engineering neonatal Fc receptor-mediated recycling and transcytosis in recombinant proteins by short terminal peptide extensions. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16095-100. PMID: 22991460; PMCID: PMC3479544.
    29. Motion JP, Nguyen J, Szoka FC. Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds. Angew Chem Int Ed Engl. 2012 Sep 03; 51(36):9047-51. PMID: 22887437; PMCID: PMC3470804.
    30. Nguyen J, Walsh CL, Motion JP, Perttu EK, Szoka F. Controlled nucleation of lipid nanoparticles. Pharm Res. 2012 Aug; 29(8):2236-48. PMID: 22544683.
      View in: PubMed
    31. Walsh CL, Nguyen J, Szoka FC. Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties. Chem Commun (Camb). 2012 Jun 07; 48(45):5575-7. PMID: 22538384.
      View in: PubMed
    32. Nguyen J, Szoka FC. Nucleic acid delivery: the missing pieces of the puzzle? Acc Chem Res. 2012 Jul 17; 45(7):1153-62. PMID: 22428908; PMCID: PMC3399092.
    33. Perttu EK, Kohli AG, Szoka FC. Inverse-phosphocholine lipids: a remix of a common phospholipid. J Am Chem Soc. 2012 Mar 14; 134(10):4485-8. PMID: 22364493; PMCID: PMC3303984.
    34. Kohli AG, Walsh CL, Szoka FC. Synthesis and characterization of betaine-like diacyl lipids: zwitterionic lipids with the cationic amine at the bilayer interface. Chem Phys Lipids. 2012 Feb; 165(2):252-9. PMID: 22301334; PMCID: PMC3288814.
    35. Perttu EK, Szoka FC. Zwitterionic sulfobetaine lipids that form vesicles with salt-dependent thermotropic properties. Chem Commun (Camb). 2011 Dec 21; 47(47):12613-5. PMID: 22045250.
      View in: PubMed
    36. Huang Z, Li W, Szoka FC. Asymmetric 1-alkyl-2-acyl phosphatidylcholine: a helper lipid for enhanced non-viral gene delivery. Int J Pharm. 2012 May 01; 427(1):64-70. PMID: 21718766; PMCID: PMC3207009.
    37. Riviere K, Kieler-Ferguson HM, Jerger K, Szoka FC. Anti-tumor activity of liposome encapsulated fluoroorotic acid as a single agent and in combination with liposome irinotecan. J Control Release. 2011 Aug 10; 153(3):288-96. PMID: 21600250; PMCID: PMC3148779.
    38. Chen B, van der Poll DG, Jerger K, Floyd WC, Fréchet JM, Szoka FC. Synthesis and properties of star-comb polymers and their doxorubicin conjugates. Bioconjug Chem. 2011 Apr 20; 22(4):617-24. PMID: 21375296; PMCID: PMC3101114.
    39. Guy RH, Szoka FC. Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion. Phys Chem Chem Phys. 2011 Mar 28; 13(12):5346-52. PMID: 21286598.
      View in: PubMed
    40. Iman M, Huang Z, Szoka FC, Jaafari MR. Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a di-stigma-steryl-hemi-succinoyl-glycero-phosphocholine liposome-intercalated amphotericin B. Int J Pharm. 2011 Apr 15; 408(1-2):163-72. PMID: 21277963; PMCID: PMC3071037.
    41. Floyd WC, Datta GK, Imamura S, Kieler-Ferguson HM, Jerger K, Patterson AW, Fox ME, Szoka FC, Fréchet JM, Ellman JA. Chemotherapeutic evaluation of a synthetic tubulysin analogue-dendrimer conjugate in c26 tumor bearing mice. ChemMedChem. 2011 Jan 03; 6(1):49-53. PMID: 20973119; PMCID: PMC3470805.
    42. Watson DS, Platt VM, Cao L, Venditto VJ, Szoka FC. Antibody response to polyhistidine-tagged peptide and protein antigens attached to liposomes via lipid-linked nitrilotriacetic acid in mice. Clin Vaccine Immunol. 2011 Feb; 18(2):289-97. PMID: 21159923; PMCID: PMC3067350.
    43. Motion JP, Huynh GH, Szoka FC, Siegel RA. Convection and retro-convection enhanced delivery: some theoretical considerations related to drug targeting. Pharm Res. 2011 Mar; 28(3):472-9. PMID: 20963628; PMCID: PMC3044083.
    44. Platt V, Huang Z, Cao L, Tiffany M, Riviere K, Szoka FC. Influence of multivalent nitrilotriacetic acid lipid-ligand affinity on the circulation half-life in mice of a liposome-attached His6-protein. Bioconjug Chem. 2010 May 19; 21(5):892-902. PMID: 20384362; PMCID: PMC2874083.
    45. van der Poll DG, Kieler-Ferguson HM, Floyd WC, Guillaudeu SJ, Jerger K, Szoka FC, Fréchet JM. Design, synthesis, and biological evaluation of a robust, biodegradable dendrimer. Bioconjug Chem. 2010 Apr 21; 21(4):764-73. PMID: 20353169; PMCID: PMC2884961.
    46. Riviere K, Huang Z, Jerger K, Macaraeg N, Szoka FC. Antitumor effect of folate-targeted liposomal doxorubicin in KB tumor-bearing mice after intravenous administration. J Drug Target. 2011 Jan; 19(1):14-24. PMID: 20353291; PMCID: PMC2999654.
    47. Johansen EB, Szoka FC, Zaleski A, Apicella MA, Gibson BW. Utilizing the O-antigen lipopolysaccharide biosynthesis pathway in Escherichia coli to interrogate the substrate specificities of exogenous glycosyltransferase genes in a combinatorial approach. Glycobiology. 2010 Jun; 20(6):763-74. PMID: 20208062; PMCID: PMC2900885.
    48. Fox ME, Guillaudeu S, Fréchet JM, Jerger K, Macaraeg N, Szoka FC. Synthesis and in vivo antitumor efficacy of PEGylated poly(l-lysine) dendrimer-camptothecin conjugates. Mol Pharm. 2009 Sep-Oct; 6(5):1562-72. PMID: 19588994; PMCID: PMC2765109.
    49. Fox ME, Szoka FC, Fréchet JM. Soluble polymer carriers for the treatment of cancer: the importance of molecular architecture. Acc Chem Res. 2009 Aug 18; 42(8):1141-51. PMID: 19555070; PMCID: PMC2759385.
    50. Huang Z, Hwang P, Watson DS, Cao L, Szoka FC. Tris-nitrilotriacetic acids of subnanomolar affinity toward hexahistidine tagged molecules. Bioconjug Chem. 2009 Aug 19; 20(8):1667-72. PMID: 19650657; PMCID: PMC2889198.
    51. Watson DS, Huang Z, Szoka FC. All-trans retinoic acid potentiates the antibody response in mice to a lipopeptide antigen adjuvanted with liposomal lipid A. Immunol Cell Biol. 2009 Nov-Dec; 87(8):630-3. PMID: 19597529; PMCID: PMC2784135.
    52. Watson DS, Szoka FC. Role of lipid structure in the humoral immune response in mice to covalent lipid-peptides from the membrane proximal region of HIV-1 gp41. Vaccine. 2009 Jul 23; 27(34):4672-83. PMID: 19520200; PMCID: PMC2730955.
    53. Chen B, Jerger K, Fréchet JM, Szoka FC. The influence of polymer topology on pharmacokinetics: differences between cyclic and linear PEGylated poly(acrylic acid) comb polymers. J Control Release. 2009 Dec 16; 140(3):203-9. PMID: 19465070; PMCID: PMC2788102.
    54. Park JI, Cao L, Platt VM, Huang Z, Stull RA, Dy EE, Sperinde JJ, Yokoyama JS, Szoka FC. Antitumor therapy mediated by 5-fluorocytosine and a recombinant fusion protein containing TSG-6 hyaluronan binding domain and yeast cytosine deaminase. Mol Pharm. 2009 May-Jun; 6(3):801-12. PMID: 19265397; PMCID: PMC2706098.
    55. Nasongkla N, Chen B, Macaraeg N, Fox ME, Fréchet JM, Szoka FC. Dependence of pharmacokinetics and biodistribution on polymer architecture: effect of cyclic versus linear polymers. J Am Chem Soc. 2009 Mar 25; 131(11):3842-3. PMID: 19256497; PMCID: PMC2668136.
    56. Cohen RN, van der Aa MA, Macaraeg N, Lee AP, Szoka FC. Quantification of plasmid DNA copies in the nucleus after lipoplex and polyplex transfection. J Control Release. 2009 Apr 17; 135(2):166-74. PMID: 19211029; PMCID: PMC2765102.
    57. Huang Z, Jaafari MR, Szoka FC. Disterolphospholipids: nonexchangeable lipids and their application to liposomal drug delivery. Angew Chem Int Ed Engl. 2009; 48(23):4146-9. PMID: 19425026; PMCID: PMC2773798.
    58. Huang Z, Szoka FC. Sterol-modified phospholipids: cholesterol and phospholipid chimeras with improved biomembrane properties. J Am Chem Soc. 2008 Nov 19; 130(46):15702-12. PMID: 18950160; PMCID: PMC2701441.
    59. Platt VM, Szoka FC. Anticancer therapeutics: targeting macromolecules and nanocarriers to hyaluronan or CD44, a hyaluronan receptor. Mol Pharm. 2008 Jul-Aug; 5(4):474-86. PMID: 18547053; PMCID: PMC2772999.
    60. MacKay JA, Li W, Huang Z, Dy EE, Huynh G, Tihan T, Collins R, Deen DF, Szoka FC. HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced delivery. Mol Ther. 2008 May; 16(5):893-900. PMID: 18388927.
      View in: PubMed
    61. Szoka F. Molecular biology. The art of assembly. Science. 2008 Feb 01; 319(5863):578-9. PMID: 18239114.
      View in: PubMed
    62. Guillaudeu SJ, Fox ME, Haidar YM, Dy EE, Szoka FC, Fréchet JM. PEGylated dendrimers with core functionality for biological applications. Bioconjug Chem. 2008 Feb; 19(2):461-9. PMID: 18173227.
      View in: PubMed
    63. Chen H, Zhang H, McCallum CM, Szoka FC, Guo X. Unsaturated cationic ortho esters for endosome permeation in gene delivery. J Med Chem. 2007 Sep 06; 50(18):4269-78. PMID: 17691717.
      View in: PubMed
    64. Li W, Suez I, Szoka FC. Reconstitution of the M13 major coat protein and its transmembrane peptide segment on a DNA template. Biochemistry. 2007 Jul 24; 46(29):8579-91. PMID: 17595059.
      View in: PubMed
    65. Karpuj MV, Giles K, Gelibter-Niv S, Scott MR, Lingappa VR, Szoka FC, Peretz D, Denetclaw W, Prusiner SB. Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells. Mol Med. 2007 Mar-Apr; 13(3-4):190-8. PMID: 17592554; PMCID: PMC1892763.
    66. Li W, Szoka FC. Lipid-based nanoparticles for nucleic acid delivery. Pharm Res. 2007 Mar; 24(3):438-49. PMID: 17252188.
      View in: PubMed
    67. Huynh GH, Ozawa T, Deen DF, Tihan T, Szoka FC. Retro-convection enhanced delivery to increase blood to brain transfer of macromolecules. Brain Res. 2007 Jan 12; 1128(1):181-90. PMID: 17125752.
      View in: PubMed
    68. Huang Z, Park JI, Watson DS, Hwang P, Szoka FC. Facile synthesis of multivalent nitrilotriacetic acid (NTA) and NTA conjugates for analytical and drug delivery applications. Bioconjug Chem. 2006 Nov-Dec; 17(6):1592-600. PMID: 17105240.
      View in: PubMed
    69. Lee CC, Gillies ER, Fox ME, Guillaudeu SJ, Fréchet JM, Dy EE, Szoka FC. A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16649-54. PMID: 17075050; PMCID: PMC1636509.
    70. Ruhela D, Riviere K, Szoka FC. Efficient synthesis of an aldehyde functionalized hyaluronic acid and its application in the preparation of hyaluronan-lipid conjugates. Bioconjug Chem. 2006 Sep-Oct; 17(5):1360-3. PMID: 16984148.
      View in: PubMed
    71. Lee CC, Cramer AT, Szoka FC, Fréchet JM. An intramolecular cyclization reaction is responsible for the in vivo inefficacy and apparent pH insensitive hydrolysis kinetics of hydrazone carboxylate derivatives of doxorubicin. Bioconjug Chem. 2006 Sep-Oct; 17(5):1364-8. PMID: 16984149.
      View in: PubMed
    72. Li W, Szoka FC. Bioresponsive targeted charge neutral lipid vesicles for systemic gene delivery. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485781.
      View in: PubMed
    73. Huang Z, Guo X, Li W, MacKay JA, Szoka FC. Acid-triggered transformation of diortho ester phosphocholine liposome. J Am Chem Soc. 2006 Jan 11; 128(1):60-1. PMID: 16390121; PMCID: PMC3280609.
    74. Lee CC, MacKay JA, Fréchet JM, Szoka FC. Designing dendrimers for biological applications. Nat Biotechnol. 2005 Dec; 23(12):1517-26. PMID: 16333296.
      View in: PubMed
    75. Huynh GH, Deen DF, Szoka FC. Barriers to carrier mediated drug and gene delivery to brain tumors. J Control Release. 2006 Jan 10; 110(2):236-59. PMID: 16318895.
      View in: PubMed
    76. Lee CC, Yoshida M, Fréchet JM, Dy EE, Szoka FC. In vitro and in vivo evaluation of hydrophilic dendronized linear polymers. Bioconjug Chem. 2005 May-Jun; 16(3):535-41. PMID: 15898719.
      View in: PubMed
    77. Huang Z, Li W, MacKay JA, Szoka FC. Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers. Mol Ther. 2005 Mar; 11(3):409-17. PMID: 15727937.
      View in: PubMed
    78. Gillies ER, Dy E, Fréchet JM, Szoka FC. Biological evaluation of polyester dendrimer: poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture. Mol Pharm. 2005 Mar-Apr; 2(2):129-38. PMID: 15804187.
      View in: PubMed
    79. Tang MX, Li W, Szoka FC. Toroid formation in charge neutralized flexible or semi-flexible biopolymers: potential pathway for assembly of DNA carriers. J Gene Med. 2005 Mar; 7(3):334-42. PMID: 15515145.
      View in: PubMed
    80. Choi SJ, Sperinde JJ, Szoka FC. Identification of a deoxyribonuclease I inhibitor from a phage-peptide library. Mol Cells. 2005 Feb 28; 19(1):54-9. PMID: 15750340.
      View in: PubMed
    81. MacKay JA, Deen DF, Szoka FC. Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating. Brain Res. 2005 Feb 28; 1035(2):139-53. PMID: 15722054.
      View in: PubMed
    82. Cohen RN, Rashkin MJ, Wen X, Szoka FC. Molecular motors as drug delivery vehicles. Drug Discov Today Technol. 2005; 2(1):111-8. PMID: 24981763.
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    83. Li W, Huang Z, MacKay JA, Grube S, Szoka FC. Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery. J Gene Med. 2005 Jan; 7(1):67-79. PMID: 15515149.
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    84. Li W, Nicol F, Szoka FC. GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery. Adv Drug Deliv Rev. 2004 Apr 23; 56(7):967-85. PMID: 15066755.
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    85. Eliaz RE, Nir S, Marty C, Szoka FC. Determination and modeling of kinetics of cancer cell killing by doxorubicin and doxorubicin encapsulated in targeted liposomes. Cancer Res. 2004 Jan 15; 64(2):711-8. PMID: 14744789.
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    86. Guo X, Huang Z, Szoka FC. Improved preparation of PEG-diortho ester-diacyl glycerol conjugates. Methods Enzymol. 2004; 387:147-52. PMID: 15172162.
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    87. Eliaz RE, Nir S, Szoka FC. Interactions of hyaluronan-targeted liposomes with cultured cells: modeling of binding and endocytosis. Methods Enzymol. 2004; 387:16-33. PMID: 15172155.
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    88. Sonawane ND, Szoka FC, Verkman AS. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem. 2003 Nov 07; 278(45):44826-31. PMID: 12944394.
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    89. Guo X, Szoka FC. Chemical approaches to triggerable lipid vesicles for drug and gene delivery. Acc Chem Res. 2003 May; 36(5):335-41. PMID: 12755643.
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    90. Guo X, MacKay JA, Szoka FC. Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid. Biophys J. 2003 Mar; 84(3):1784-95. PMID: 12609880; PMCID: PMC1302747.
    91. Choi JS, MacKay JA, Szoka FC. Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization. Bioconjug Chem. 2003 Mar-Apr; 14(2):420-9. PMID: 12643753.
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    92. Swanson B, Savel R, Szoka F, Sawa T, Wiener-Kronish J. Development of a high throughput Pseudomonas aeruginosa epithelial cell adhesion assay. J Microbiol Methods. 2003 Mar; 52(3):361-6. PMID: 12531505.
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    93. Mackay JA, Szoka FC. HIV TAT Protein Transduction Domain Mediated Cell Binding and Intracellular Delivery of Nanoparticles. J Dispers Sci Technol. 2003; 24(3):465-473. PMID: 20808712.
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    94. Bronich TK, Ouyang M, Kabanov VA, Eisenberg A, Szoka FC, Kabanov AV. Synthesis of vesicles on polymer template. J Am Chem Soc. 2002 Oct 09; 124(40):11872-3. PMID: 12358530.
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    95. Ihre HR, Padilla De Jesús OL, Szoka FC, Fréchet JM. Polyester dendritic systems for drug delivery applications: design, synthesis, and characterization. Bioconjug Chem. 2002 May-Jun; 13(3):443-52. PMID: 12009932.
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    96. Padilla De Jesús OL, Ihre HR, Gagne L, Fréchet JM, Szoka FC. Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation. Bioconjug Chem. 2002 May-Jun; 13(3):453-61. PMID: 12009933.
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    97. Hirota S, de Ilarduya CT, Barron LG, Szoka FC. Simple mixing device to reproducibly prepare cationic lipid-DNA complexes (lipoplexes). Biotechniques. 1999 Aug; 27(2):286-90. PMID: 10457833.
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    98. Felgner PL, Barenholz Y, Behr JP, Cheng SH, Cullis P, Huang L, Jessee JA, Seymour L, Szoka F, Thierry AR, Wagner E, Wu G. Nomenclature for synthetic gene delivery systems. Hum Gene Ther. 1997 Mar 20; 8(5):511-2. PMID: 9095402.
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