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    Anthony Defranco, PhD

    SchoolUCSF School of Medicine
    DepartmentMicrobiology and Immunology
    Address513 Parnassus Ave
    San Francisco CA 94143
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Beck-Engeser GB, Winkelmann R, Wheeler ML, Shansab M, Yu P, Wünsche S, Walchhütter A, Metzner M, Vettermann C, Eilat D, DeFranco A, Jäck HM, Wabl M. APOBEC3 enzymes restrict marginal zone B cells. Eur J Immunol. 2015 Mar; 45(3):695-704.
        View in: PubMed
      2. Rookhuizen DC, DeFranco AL. Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses. Proc Natl Acad Sci U S A. 2014 Aug 5; 111(31):E3224-33.
        View in: PubMed PMC4128120
      3. Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D, Hu B, Ransohoff RM, Harding CV, Hise AG, Hazen SL, DeFranco AL, Fox PL, Morton RE, Dicorleto PE, Febbraio M, Nagy LE, Smith JD, Wang JA, Li X. MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. J Exp Med. 2014 May 5; 211(5):887-907.
        View in: PubMed PMC4010914
      4. Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol. 2014 Feb 1; 192(3):875-85.
        View in: PubMed PMC4101002
      5. Lamagna C, Hu Y, DeFranco AL, Lowell CA. B cell-specific loss of Lyn kinase leads to autoimmunity. J Immunol. 2014 Feb 1; 192(3):919-28.
        View in: PubMed PMC3900234
      6. Wheeler ML, Dong MB, Brink R, Zhong XP, DeFranco AL. Diacylglycerol kinase ? limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. Sci Signal. 2013 Oct 15; 6(297):ra91.
        View in: PubMed PMC4108475
      7. Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3311-20.
        View in: PubMed PMC3761623
      8. Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, Wu GD, Choi Y. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity. 2013 Jun 27; 38(6):1211-22.
        View in: PubMed PMC3715143
      9. Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A. Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol. 2013 Jul 15; 191(2):535-9.
        View in: PubMed PMC3702626
      10. Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F. Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-?-dependent elimination of Paneth cells. Nat Immunol. 2013 Feb; 14(2):136-42.
        View in: PubMed PMC3552073
      11. Kim CC, Nelson CS, Wilson EB, Hou B, DeFranco AL, DeRisi JL. Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control. PLoS One. 2012; 7(10):e48126.
        View in: PubMed PMC3483282
      12. Wheeler ML, Defranco AL. Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation. J Immunol. 2012 Nov 1; 189(9):4405-16.
        View in: PubMed PMC3515638
      13. DeFranco AL, Rookhuizen DC, Hou B. Contribution of Toll-like receptor signaling to germinal center antibody responses. Immunol Rev. 2012 May; 247(1):64-72.
        View in: PubMed PMC3334874
      14. Thompson AL, Johnson BT, Sempowski GD, Gunn MD, Hou B, DeFranco AL, Staats HF. Maximal adjuvant activity of nasally delivered IL-1a requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production. J Immunol. 2012 Mar 15; 188(6):2834-46.
        View in: PubMed PMC3293937
      15. Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F. B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity. 2012 Feb 24; 36(2):228-38.
        View in: PubMed PMC3288553
      16. Shahaf G, Gross AJ, Sternberg-Simon M, Kaplan D, DeFranco AL, Mehr R. Lyn deficiency affects B-cell maturation as well as survival. Eur J Immunol. 2012 Feb; 42(2):511-21.
        View in: PubMed PMC3516919
      17. Gross AJ, Proekt I, DeFranco AL. Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells. Eur J Immunol. 2011 Dec; 41(12):3645-55.
        View in: PubMed PMC3517141
      18. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol. 2011 Dec; 12(12):1184-93.
        View in: PubMed PMC3419270
      19. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32.
        View in: PubMed PMC3193193
      20. Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV. Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8743-8.
        View in: PubMed PMC3102410
      21. Hou B, Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L, Lee LM, Coffman RL, Bachmann MF, DeFranco AL. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity. 2011 Mar 25; 34(3):375-84.
        View in: PubMed PMC3064721
      22. Rahman AH, Zhang R, Blosser CD, Hou B, Defranco AL, Maltzman JS, Wherry EJ, Turka LA. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood. 2011 Mar 17; 117(11):3123-30.
        View in: PubMed PMC3062314
      23. Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F. Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci U S A. 2011 Jan 4; 108(1):278-83.
        View in: PubMed PMC3017180
      24. Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med. 2010 Aug 2; 207(8):1757-73.
        View in: PubMed PMC2916124
      25. Mamchak AA, Thien CB, Dagger SA, Lyandres J, Jiang S, Langdon WY, DeFranco AL. Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice. Eur J Immunol. 2010 Feb; 40(2):539-47.
        View in: PubMed PMC2976765
      26. Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol. 2009 May 1; 182(9):5382-92.
        View in: PubMed PMC2840041
      27. DeFranco AL. "Dangerous crystals". Immunity. 2008 Nov 14; 29(5):670-1.
        View in: PubMed
      28. Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol. 2008 Oct 15; 181(8):5374-85.
        View in: PubMed PMC2657555
      29. Hou B, Reizis B, DeFranco AL. Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity. 2008 Aug 15; 29(2):272-82.
        View in: PubMed PMC2847796
      30. Gupta N, DeFranco AL. Lipid rafts and B cell signaling. Semin Cell Dev Biol. 2007 Oct; 18(5):616-26.
        View in: PubMed PMC2169358
      31. Gupta N, Wollscheid B, Watts JD, Scheer B, Aebersold R, DeFranco AL. Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics. Nat Immunol. 2006 Jun; 7(6):625-33.
        View in: PubMed
      32. Nishiya T, Kajita E, Miwa S, Defranco AL. TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J Biol Chem. 2005 Nov 4; 280(44):37107-17.
        View in: PubMed
      33. Tian MT, Gonzalez G, Scheer B, DeFranco AL. Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood. 2005 Sep 15; 106(6):2105-12.
        View in: PubMed PMC1895143
      34. Nishiya T, DeFranco AL. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem. 2004 Apr 30; 279(18):19008-17.
        View in: PubMed
      35. Gupta N, DeFranco AL. Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell. 2003 Feb; 14(2):432-44.
        View in: PubMed PMC149983
      36. Yu CC, Mamchak AA, DeFranco AL. Signaling mutations and autoimmunity. Curr Dir Autoimmun. 2003; 6:61-88.
        View in: PubMed
      37. Ohashi PS, DeFranco AL. Making and breaking tolerance. Curr Opin Immunol. 2002 Dec; 14(6):744-59.
        View in: PubMed
      38. DeFranco AL. Vav and the B cell signalosome. Nat Immunol. 2001 Jun; 2(6):482-4.
        View in: PubMed
      39. Tian MT, Chou CH, DeFranco AL. Apoptosis induced by the antigen receptor and Fas in a variant of the immature B cell line WEHI-231 and in splenic immature B cells. Int Immunol. 2001 Apr; 13(4):581-92.
        View in: PubMed
      40. Richards JD, Davé SH, Chou CH, Mamchak AA, DeFranco AL. Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen. J Immunol. 2001 Mar 15; 166(6):3855-64.
        View in: PubMed
      41. Yu CC, Yen TS, Lowell CA, DeFranco AL. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr Biol. 2001 Jan 9; 11(1):34-8.
        View in: PubMed
      42. DeFranco AL. B-cell activation 2000. Immunol Rev. 2000 Aug; 176:5-9.
        View in: PubMed
      43. Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity. 2000 Jul; 13(1):47-57.
        View in: PubMed
      44. Weinstein SL, Finn AJ, Davé SH, Meng F, Lowell CA, Sanghera JS, DeFranco AL. Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta. J Leukoc Biol. 2000 Mar; 67(3):405-14.
        View in: PubMed
      45. Fitzer-Attas CJ, Lowry M, Crowley MT, Finn AJ, Meng F, DeFranco AL, Lowell CA. Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J Exp Med. 2000 Feb 21; 191(4):669-82.
        View in: PubMed PMC2195832
      46. Harmer SL, DeFranco AL. The src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes. J Biol Chem. 1999 Apr 23; 274(17):12183-91.
        View in: PubMed
      47. MacKichan ML, DeFranco AL. Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog. J Biol Chem. 1999 Jan 15; 274(3):1767-75.
        View in: PubMed
      48. DeFranco AL, Chan VW, Lowell CA. Positive and negative roles of the tyrosine kinase Lyn in B cell function. Semin Immunol. 1998 Aug; 10(4):299-307.
        View in: PubMed
      49. Chan VW, Lowell CA, DeFranco AL. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol. 1998 May 7; 8(10):545-53.
        View in: PubMed
      50. DeFranco AL, Crowley MT, Finn A, Hambleton J, Weinstein SL. The role of tyrosine kinases and map kinases in LPS-induced signaling. Prog Clin Biol Res. 1998; 397:119-36.
        View in: PubMed
      51. Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med. 1997 Oct 6; 186(7):1027-39.
        View in: PubMed PMC2199061
      52. Harmer SL, DeFranco AL. Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes. Mol Cell Biol. 1997 Jul; 17(7):4087-95.
        View in: PubMed PMC232262
      53. Chan VW, Meng F, Soriano P, DeFranco AL, Lowell CA. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997 Jul; 7(1):69-81.
        View in: PubMed
      54. DeFranco AL. The complexity of signaling pathways activated by the BCR. Curr Opin Immunol. 1997 Jun; 9(3):296-308.
        View in: PubMed
      55. Roth PE, DeFranco AL. Receptor tails unlock developmental checkpoints for B lymphocytes. Science. 1996 Jun 21; 272(5269):1752-4.
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      56. DeFranco AL. The two-headed antigen. B-cell co-receptors. Curr Biol. 1996 May 1; 6(5):548-50.
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      57. Hambleton J, Weinstein SL, Lem L, DeFranco AL. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci U S A. 1996 Apr 2; 93(7):2774-8.
        View in: PubMed PMC39708
      58. Richards JD, Gold MR, Hourihane SL, DeFranco AL, Matsuuchi L. Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. J Biol Chem. 1996 Mar 15; 271(11):6458-66.
        View in: PubMed
      59. Horne MC, Roth PE, DeFranco AL. Assembly of the truncated immunoglobulin heavy chain D mu into antigen receptor-like complexes in pre-B cells but not in B cells. Immunity. 1996 Feb; 4(2):145-58.
        View in: PubMed
      60. Crowley MT, Harmer SL, DeFranco AL. Activation-induced association of a 145-kDa tyrosine-phosphorylated protein with Shc and Syk in B lymphocytes and macrophages. J Biol Chem. 1996 Jan 12; 271(2):1145-52.
        View in: PubMed
      61. DeFranco AL, Richards JD, Blum JH, Stevens TL, Law DA, Chan VW, Datta SK, Foy SP, Hourihane SL, Gold MR, et al. Signal transduction by the B-cell antigen receptor. Ann N Y Acad Sci. 1995 Sep 7; 766:195-201.
        View in: PubMed
      62. Hambleton J, McMahon M, DeFranco AL. Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events. J Exp Med. 1995 Jul 1; 182(1):147-54.
        View in: PubMed PMC2192101
      63. DeFranco AL, Law DA. Tyrosine phosphatases and the antibody response. Science. 1995 Apr 14; 268(5208):263-4.
        View in: PubMed
      64. DeFranco AL. Transmembrane signaling by antigen receptors of B and T lymphocytes. Curr Opin Cell Biol. 1995 Apr; 7(2):163-75.
        View in: PubMed
      65. Roth PE, DeFranco AL. Lymphocyte development. Intrinsic checkpoints for lineage progression. Curr Biol. 1995 Apr 1; 5(4):349-52.
        View in: PubMed
      66. DeFranco AL, Hambleton J, McMahon M, Weinstein SL. Examination of the role of MAP kinase in the response of macrophages to lipopolysaccharide. Prog Clin Biol Res. 1995; 392:407-20.
        View in: PubMed
      67. DeFranco AL. Signaling pathways activated by protein tyrosine phosphorylation in lymphocytes. Curr Opin Immunol. 1994 Jun; 6(3):364-71.
        View in: PubMed
      68. Stevens TL, Blum JH, Foy SP, Matsuuchi L, DeFranco AL. A mutation of the mu transmembrane that disrupts endoplasmic reticulum retention. Effects on association with accessory proteins and signal transduction. J Immunol. 1994 May 1; 152(9):4397-406.
        View in: PubMed
      69. DeFranco AL, Blum JH, Stevens TL, Law DA, Chan VW, Foy SP, Datta SK, Matsuuchi L. Structure and function of the B-cell antigen receptor. Chem Immunol. 1994; 59:156-72.
        View in: PubMed
      70. DeFranco AL, Mittelstadt PR, Blum JH, Stevens TL, Law DA, Chan VW, Foy SP, Datta SK, Matsuuchi L. Mechanism of B cell antigen receptor function: transmembrane signaling and triggering of apoptosis. Adv Exp Med Biol. 1994; 365:9-22.
        View in: PubMed
      71. Gold MR, DeFranco AL. Biochemistry of B lymphocyte activation. Adv Immunol. 1994; 55:221-95.
        View in: PubMed
      72. Blum JH, Stevens TL, DeFranco AL. Role of the mu immunoglobulin heavy chain transmembrane and cytoplasmic domains in B cell antigen receptor expression and signal transduction. J Biol Chem. 1993 Dec 25; 268(36):27236-45.
        View in: PubMed
      73. Law DA, Chan VW, Datta SK, DeFranco AL. B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn. Curr Biol. 1993 Oct 1; 3(10):645-57.
        View in: PubMed
      74. DeFranco AL. Signaling the insulin receptor way. Curr Biol. 1993 Oct 1; 3(10):713-5.
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      75. Weinstein SL, June CH, DeFranco AL. Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14. J Immunol. 1993 Oct 1; 151(7):3829-38.
        View in: PubMed
      76. Shapiro AM, Schlissel MS, Baltimore D, DeFranco AL. Stimulation of kappa light-chain gene rearrangement by the immunoglobulin mu heavy chain in a pre-B-cell line. Mol Cell Biol. 1993 Sep; 13(9):5679-90.
        View in: PubMed PMC360301
      77. Mittelstadt PR, DeFranco AL. Induction of early response genes by cross-linking membrane Ig on B lymphocytes. J Immunol. 1993 Jun 1; 150(11):4822-32.
        View in: PubMed
      78. Gold MR, Crowley MT, Martin GA, McCormick F, DeFranco AL. Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins. J Immunol. 1993 Jan 15; 150(2):377-86.
        View in: PubMed
      79. DeFranco AL. Structure and function of the B cell antigen receptor. Annu Rev Cell Biol. 1993; 9:377-410.
        View in: PubMed
      80. DeFranco AL. Tyrosine phosphorylation and the mechanism of signal transduction by the B-lymphocyte antigen receptor. Eur J Biochem. 1992 Dec 1; 210(2):381-8.
        View in: PubMed
      81. Weinstein SL, Sanghera JS, Lemke K, DeFranco AL, Pelech SL. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J Biol Chem. 1992 Jul 25; 267(21):14955-62.
        View in: PubMed
      82. Law DA, Gold MR, DeFranco AL. Examination of B lymphoid cell lines for membrane immunoglobulin-stimulated tyrosine phosphorylation and src-family tyrosine kinase mRNA expression. Mol Immunol. 1992 Jul-Aug; 29(7-8):917-26.
        View in: PubMed
      83. Hempel WM, Schatzman RC, DeFranco AL. Tyrosine phosphorylation of phospholipase C-gamma 2 upon cross-linking of membrane Ig on murine B lymphocytes. J Immunol. 1992 May 15; 148(10):3021-7.
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      84. DeFranco AL. Autoimmunity. Hidden lymphocytes. Nature. 1992 May 7; 357(6373):14-5.
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      85. Matsuuchi L, Gold MR, Travis A, Grosschedl R, DeFranco AL, Kelly RB. The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3404-8.
        View in: PubMed PMC48876
      86. Gold MR, Chan VW, Turck CW, DeFranco AL. Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes. J Immunol. 1992 Apr 1; 148(7):2012-22.
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      87. DeFranco AL. bcl-2 to the rescue. Curr Biol. 1992 Feb; 2(2):95-7.
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      88. Gold MR, Gajewski TF, DeFranco AL. Regulation of anti-immunoglobulin-induced B lymphoma growth arrest by transforming growth factor beta 1 and dexamethasone. Int Immunol. 1991 Nov; 3(11):1091-8.
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      89. DeFranco AL. All about B cells. Cancer Cells. 1991 Nov; 3(11):450-3.
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      90. DeFranco AL. Signal transduction. Immunosuppressants at work. Nature. 1991 Aug 29; 352(6338):754-5.
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      91. DeFranco AL. Between B cells and T cells. Nature. 1991 Jun 20; 351(6328):603-4.
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      92. Hempel WM, DeFranco AL. Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1; 146(11):3713-20.
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      93. Weinstein SL, Gold MR, DeFranco AL. Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4148-52.
        View in: PubMed PMC51615
      94. Gold MR, Matsuuchi L, Kelly RB, DeFranco AL. Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):3436-40.
        View in: PubMed PMC51462
      95. Page DM, Gold MR, Fahey KA, Matsuuchi L, DeFranco AL. Mutational analysis of antigen receptor regulation of B lymphocyte growth. Evidence for involvement of the phosphoinositide signaling pathway. J Biol Chem. 1991 Mar 25; 266(9):5563-74.
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      96. Gold MR, Law DA, DeFranco AL. Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor. Nature. 1990 Jun 28; 345(6278):810-3.
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      97. Page DM, DeFranco AL. Antigen receptor-induced cell cycle arrest in WEHI-231 B lymphoma cells depends on the duration of signaling before the G1 phase restriction point. Mol Cell Biol. 1990 Jun; 10(6):3003-12.
        View in: PubMed PMC360664
      98. DeFranco AL. Immunology. Tolerance: a second mechanism. Nature. 1989 Nov 23; 342(6248):340-1.
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      99. DeFranco AL, Page DM, Blum JH, Gold MR. Signal transduction by the antigen receptor of B lymphocytes. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 2:733-40.
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      100. DeFranco AL, Gold MR. Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling. Adv Exp Med Biol. 1989; 254:101-12.
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      101. DeFranco AL. Fate of self-reactive B cells. Nature. 1988 Aug 25; 334(6184):652-3.
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      102. DeFranco AL. Cell-cell interactions in the antibody response. Nature. 1988 Jul 21; 334(6179):199-200.
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      103. Page DM, DeFranco AL. Role of phosphoinositide-derived second messengers in mediating anti-IgM-induced growth arrest of WEHI-231 B lymphoma cells. J Immunol. 1988 Jun 1; 140(11):3717-26.
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      104. Gold MR, Jakway JP, DeFranco AL. Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown. J Immunol. 1987 Dec 1; 139(11):3604-13.
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      105. Fahey KA, DeFranco AL. Cross-linking membrane IgM induces production of inositol trisphosphate and inositol tetrakisphosphate in WEHI-231 B lymphoma cells. J Immunol. 1987 Jun 1; 138(11):3935-42.
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      106. Gold MR, DeFranco AL. Phorbol esters and dioctanoylglycerol block anti-IgM-stimulated phosphoinositide hydrolysis in the murine B cell lymphoma WEHI-231. J Immunol. 1987 Feb 1; 138(3):868-76.
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      107. DeFranco AL, Gold MR, Jakway JP. B-lymphocyte signal transduction in response to anti-immunoglobulin and bacterial lipopolysaccharide. Immunol Rev. 1987 Feb; 95:161-76.
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      108. DeFranco AL. Transmembrane signaling reactions generated in B cells in response to anti-IgM or lipopolysaccharide. Adv Exp Med Biol. 1987; 213:189-93.
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      109. DeFranco AL. Molecular aspects of B-lymphocyte activation. Annu Rev Cell Biol. 1987; 3:143-78.
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      110. Jakway JP, DeFranco AL. Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide. Science. 1986 Nov 7; 234(4777):743-6.
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      111. Jakway JP, Usinger WR, Gold MR, Mishell RI, DeFranco AL. Growth regulation of the B lymphoma cell line WEHI-231 by anti-immunoglobulin, lipopolysaccharide, and other bacterial products. J Immunol. 1986 Oct 1; 137(7):2225-31.
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      112. LaBaer J, Tsien RY, Fahey KA, DeFranco AL. Stimulation of the antigen receptor on WEHI-231 B lymphoma cells results in a voltage-independent increase in cytoplasmic calcium. J Immunol. 1986 Sep 15; 137(6):1836-44.
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      113. DeFranco AL, Raveche ES, Paul WE. Separate control of B lymphocyte early activation and proliferation in response to anti-IgM antibodies. J Immunol. 1985 Jul; 135(1):87-94.
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      114. Ashwell JD, DeFranco AL, Paul WE, Schwartz RH. Can resting B cells present antigen to T cells? Fed Proc. 1985 May; 44(8):2475-9.
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      115. Ashwell JD, DeFranco AL, Paul WE, Schwartz RH. Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation. J Exp Med. 1984 Mar 1; 159(3):881-905.
        View in: PubMed PMC2187250
      116. DeFranco AL, Ashwell JD, Schwartz RH, Paul WE. Polyclonal stimulation of resting B lymphocytes by antigen-specific T lymphocytes. J Exp Med. 1984 Mar 1; 159(3):861-80.
        View in: PubMed PMC2187247
      117. DeFranco AL. Growth regulation of a B-cell lymphoma via the antigen receptor. Curr Top Microbiol Immunol. 1984; 113:92-5.
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      118. Raveche ES, Steinberg AD, DeFranco AL, Tjio JH. Cell cycle analysis of lymphocyte activation in normal and autoimmune strains of mice. J Immunol. 1982 Sep; 129(3):1219-26.
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