Anthony Defranco, PhD

Title(s)Professor Emeritus, Microbiology and Immunology
SchoolSchool of Medicine
Address513 Parnassus Avenue, MSB, #447B
San Francisco CA 94143
Phone415-476-5488
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    Organ-specific autoimmunity resulting from two genetic defects in tolerance
    NIH R01AI138479Mar 1, 2018 - Feb 28, 2023
    Role: Principal Investigator
    B cell TLRs and germinal centers
    NIH R21AI117378Jul 1, 2015 - Jun 30, 2017
    Role: Principal Investigator
    BCR regulation of antibody responses
    NIH R56AI108684Aug 1, 2014 - Jul 31, 2015
    Role: Principal Investigator
    The role of Apobec3 enzymes in regulation of marginal zone B cells
    NIH R21AI107101Jul 1, 2013 - Jun 30, 2016
    Role: Co-Principal Investigator
    Innate immune regulation of inflammation and adaptive immunity
    NIH P01AI078869Jul 15, 2008 - Jun 30, 2014
    Role: Principal Investigator
    Cell Type-Specific Roles of TLR Signaling In Immune Responses
    NIH R01AI072058Jan 1, 2008 - Dec 31, 2013
    Role: Principal Investigator
    SELECTIVE GENE ABLATION IN MATURE B LYMPHOCYTES
    NIH F06TW002281Dec 4, 1998
    Role: Principal Investigator
    TRANSFUSION BIOLOGY AND MEDICINE
    NIH P50HL054476Feb 1, 1996 - Dec 31, 2006
    Role: Co-Investigator
    Cytoskeleton and Signal Transduction in Host Defense
    NIH R01AI035811May 1, 1994 - Jan 31, 2010
    Role: Principal Investigator
    LPS-INDUCED SIGNALING IN MACROPHAGES
    NIH R01AI033442Aug 1, 1993 - Jul 31, 2001
    Role: Principal Investigator
    Molecular and Cellular Immunology
    NIH T32AI007334Sep 1, 1988 - Jul 31, 2024
    Role: Principal Investigator
    REGULATION OF IMMUNE SYSTEM CELLS BY BACTERIAL PRODUCTS
    NIH R01AI023864Apr 1, 1987 - Mar 31, 1990
    Role: Principal Investigator
    Regulation of B lymphocyte proliferation by antigen
    NIH R56AI020038Jan 1, 1984 - Jun 30, 2014
    Role: Principal Investigator
    Regulation of B Lymphocyte Proliferation by Antigen
    NIH R01AI020038Jan 1, 1984 - Nov 30, 2012
    Role: Principal Investigator
    REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    NIH R37AI020038Jan 1, 1984 - Mar 31, 2005
    Role: Principal Investigator
    Immune Tolerance and Autoimmunity
    NIH P01AI035297Jul 31, 2012
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Tracking the role of Aire in immune tolerance to the eye with a TCR transgenic mouse model. Proc Natl Acad Sci U S A. 2024 Jan 30; 121(5):e2311487121. Yin M, Smith JA, Chou M, Chan J, Jittayasothorn Y, Gould DB, Caspi RR, Anderson MS, DeFranco AL. PMID: 38261611; PMCID: PMC10835137.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    2. Development of uveitis in a mouse model of spontaneous autoimmunity correlates with frequency of autoantigen-specific regulatory T cells. The Journal of Immunology. 2022 May 1; 208(1_Supplement):44.07-44.07. Yin YM, Hiam HK, Proekt PI, Chan CJ, Hu HY, Lowell LC, Gould GD, Spitzer SM, Anderson AM, DeFranco DA. .
      View in: Publisher Site   Mentions:
    3. Autoantigen specific T-cell receptor induces organ-specific autoimmunity by escaping T cell negative selection. The Journal of Immunology. 2022 May 1; 208(1_Supplement):104.02-104.02. Yin YM, Smith SJ, Chou CM, Chan CJ, Hu HY, Lowell LC, Gould GD, Anderson AM, DeFranco DA. .
      View in: Publisher Site   Mentions:
    4. Correlation of autoantigen-specific Treg frequency with development of spontaneous organ-specific autoimmunity in a mouse model of uveitis. The Journal of Immunology. 2021 May 1; 206(1_Supplement):51.05-51.05. Yin YM, Hiam HK, Proekt PI, Chan CJ, Hu HY, Lowell LC, Gould GD, Anderson AM, DeFranco DA. .
      View in: Publisher Site   Mentions:
    5. T-cell receptor repertoire of mice with organ-specific autoimmunity resulting from a partial defect in T cell negative selection and dendritic cell enhancement. The Journal of Immunology. 2021 May 1; 206(1_Supplement):51.06-51.06. Yin YM, Smith SJ, Chou CM, Chan CJ, Hu HY, Lowell LC, Gould GD, Anderson AM, DeFranco DA. .
      View in: Publisher Site   Mentions:
    6. The Role of MAP Kinases, Phosphatidylinositol 3-Kinase, and Ceramide in LPS-induced Signaling in Macrophages. . 2020 Oct 23; 473-482. DeFranco DA, Finn FA, Hambleton HJ, Crowley CM, MacKichan MM, Weinstein WS. .
      View in: Publisher Site   Mentions:
    7. Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes. Immunohorizons. 2019 08 19; 3(8):389-401. Wigton EJ, DeFranco AL, Ansel KM. PMID: 31427364; PMCID: PMC6738343.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    8. Use of prasugrel vs clopidogrel and outcomes in patients with and without diabetes mellitus presenting with acute coronary syndrome undergoing percutaneous coronary intervention. Int J Cardiol. 2019 Jan 15; 275:31-35. Faggioni M, Baber U, Chandrasekhar J, Sartori S, Claessen BE, Rao SV, Vogel B, Effron MB, Poddar K, Farhan S, Kini A, Weintraub W, Toma C, Sorrentino S, Weiss S, Snyder C, Muhlestein JB, Kapadia S, Keller S, Strauss C, Aquino M, Baker B, Defranco A, Pocock S, Henry T, Mehran R. PMID: 30391067.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Multilayer Control of B Cell Activation by the B Cell Antigen Receptor: Following Themes Initiated With Bill Paul. Front Immunol. 2018; 9:739. DeFranco AL. PMID: 29740430; PMCID: PMC5925841.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    10. B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle. J Immunol. 2018 02 01; 200(3):937-948. Tian M, Hua Z, Hong S, Zhang Z, Liu C, Lin L, Chen J, Zhang W, Zhou X, Zhang F, DeFranco AL, Hou B. PMID: 29282308.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    11. Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells. J Leukoc Biol. 2017 09; 102(3):791-803. Costa S, Marini O, Bevilacqua D, DeFranco AL, Hou B, Lonardi S, Vermi W, Rodegher P, Panato A, Tagliaro F, Lowell CA, Cassatella MA, Girolomoni G, Scapini P. PMID: 28642279; PMCID: PMC6608051.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    12. Innate B cells cleave to the marginal zone. Nat Immunol. 2017 02 15; 18(3):248-250. DeFranco AL. PMID: 28198824.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    13. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS One. 2016; 11(12):e0167693. Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL. PMID: 27977701; PMCID: PMC5157987.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    14. LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity. J Clin Invest. 2016 10 03; 126(10):3758-3771. Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL. PMID: 27571405; PMCID: PMC5087700.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    15. Germinal centers and autoimmune disease in humans and mice. Immunol Cell Biol. 2016 11; 94(10):918-924. DeFranco AL. PMID: 27562062; PMCID: PMC5663225.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    16. MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase. PLoS Pathog. 2016 08; 12(8):e1005787. Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M. PMID: 27542117; PMCID: PMC4991787.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. The germinal center antibody response in health and disease. F1000Res. 2016; 5. DeFranco AL. PMID: 27303636; PMCID: PMC4882753.
      View in: PubMed   Mentions: 15     Fields:    
    18. Triggering of organ-specific autoimmunity through synergy of defects in key tolerance checkpoints. The Journal of Immunology. 2016 May 1; 196(1_Supplement):117.1-117.1. Proekt PI, Miller MC, Jeanne JM, Fasano FK, Lowell LC, Gould GD, Anderson AM, DeFranco DA. .
      View in: Publisher Site   Mentions:
    19. Signaling Pathways Downstream of TLRs and IL-1 Family Receptors. Encyclopedia of Immunobiology. 2016 Jan 1; 106-114. DeFranco DA. .
      View in: Publisher Site   Mentions:
    20. B Lymphocytes: Receptors. eLS. 2015 Nov 16; 1-15. DeFranco DA. .
      View in: Publisher Site   Mentions:
    21. APOBEC3 enzymes restrict marginal zone B cells. Eur J Immunol. 2015 Mar; 45(3):695-704. Beck-Engeser GB, Winkelmann R, Wheeler ML, Shansab M, Yu P, Wünsche S, Walchhütter A, Metzner M, Vettermann C, Eilat D, DeFranco A, Jäck HM, Wabl M. PMID: 25501566; PMCID: PMC4972502.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    22. Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):E3224-33. Rookhuizen DC, DeFranco AL. PMID: 25053813; PMCID: PMC4128120.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    23. MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. Journal of Experimental Medicine. 2014 May 5; 211(5):1003-1003. Yu YM, Zhou ZH, Zhao ZJ, Xiao XN, Roychowdhury RS, Schmitt SD, Hu HB, Ransohoff RR, Harding HC, Hise HA, Hazen HS, DeFranco DA, Fox FP, Morton MR, Dicorleto DP, Febbraio FM, Nagy NL, Smith SJ, Wang WJ, Li LX. .
      View in: Publisher Site   Mentions:
    24. MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. J Exp Med. 2014 May 05; 211(5):887-907. Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D, Hu B, Ransohoff RM, Harding CV, Hise AG, Hazen SL, DeFranco AL, Fox PL, Morton RE, Dicorleto PE, Febbraio M, Nagy LE, Smith JD, Wang JA, Li X. PMID: 24752299; PMCID: PMC4010914.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    25. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol. 2014 Feb 01; 192(3):875-85. Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL. PMID: 24379120; PMCID: PMC4101002.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    26. B cell-specific loss of Lyn kinase leads to autoimmunity. J Immunol. 2014 Feb 01; 192(3):919-28. Lamagna C, Hu Y, DeFranco AL, Lowell CA. PMID: 24376269; PMCID: PMC3900234.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    27. Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. Sci Signal. 2013 Oct 15; 6(297):ra91. Wheeler ML, Dong MB, Brink R, Zhong XP, DeFranco AL. PMID: 24129701; PMCID: PMC4108475.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    28. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3311-20. Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA. PMID: 23940344; PMCID: PMC3761623.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    29. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity. 2013 Jun 27; 38(6):1211-22. Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, Wu GD, Choi Y. PMID: 23791643; PMCID: PMC3715143.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    30. Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol. 2013 Jul 15; 191(2):535-9. Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A. PMID: 23785118; PMCID: PMC3702626.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    31. Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells. Nat Immunol. 2013 Feb; 14(2):136-42. Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F. PMID: 23263554; PMCID: PMC3552073.
      View in: PubMed   Mentions: 96     Fields:    Translation:AnimalsCells
    32. Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control. PLoS One. 2012; 7(10):e48126. Kim CC, Nelson CS, Wilson EB, Hou B, DeFranco AL, DeRisi JL. PMID: 23144737; PMCID: PMC3483282.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    33. Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation. J Immunol. 2012 Nov 01; 189(9):4405-16. Wheeler ML, Defranco AL. PMID: 23024271; PMCID: PMC3515638.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    34. Contribution of Toll-like receptor signaling to germinal center antibody responses. Immunol Rev. 2012 May; 247(1):64-72. DeFranco AL, Rookhuizen DC, Hou B. PMID: 22500832; PMCID: PMC3334874.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    35. Maximal adjuvant activity of nasally delivered IL-1α requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production. J Immunol. 2012 Mar 15; 188(6):2834-46. Thompson AL, Johnson BT, Sempowski GD, Gunn MD, Hou B, DeFranco AL, Staats HF. PMID: 22345651; PMCID: PMC3293937.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    36. B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity. 2012 Feb 24; 36(2):228-38. Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F. PMID: 22306056; PMCID: PMC3288553.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    37. Lyn deficiency affects B-cell maturation as well as survival. Eur J Immunol. 2012 Feb; 42(2):511-21. Shahaf G, Gross AJ, Sternberg-Simon M, Kaplan D, DeFranco AL, Mehr R. PMID: 22057631; PMCID: PMC3516919.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    38. Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells. Eur J Immunol. 2011 Dec; 41(12):3645-55. Gross AJ, Proekt I, DeFranco AL. PMID: 21928281; PMCID: PMC3517141.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    39. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol. 2011 Oct 23; 12(12):1184-93. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A. PMID: 22019834; PMCID: PMC3419270.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    40. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. PMID: 21911371; PMCID: PMC3193193.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    41. Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8743-8. Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV. PMID: 21555560; PMCID: PMC3102410.
      View in: PubMed   Mentions: 161     Fields:    Translation:AnimalsCells
    42. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity. 2011 Mar 25; 34(3):375-84. Hou B, Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L, Lee LM, Coffman RL, Bachmann MF, DeFranco AL. PMID: 21353603; PMCID: PMC3064721.
      View in: PubMed   Mentions: 126     Fields:    Translation:AnimalsCells
    43. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood. 2011 Mar 17; 117(11):3123-30. Rahman AH, Zhang R, Blosser CD, Hou B, Defranco AL, Maltzman JS, Wherry EJ, Turka LA. PMID: 21233312; PMCID: PMC3062314.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    44. The antibacterial C-type lectin RegIIIgamma maintains spatial segregation between microbiota and host in the intestine. Inflammatory Bowel Diseases. 2011 Jan 1; 17(suppl_1):s2-s3. Vaishnava VS, Severson SK, Ruhn RK, Benjamin BJ, Yu YX, Hu HB, Yamamoto YM, Defranco DA, Wakeland WE, Hooper HL. .
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    45. Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):278-83. Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F. PMID: 21173242; PMCID: PMC3017180.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    46. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med. 2010 Aug 02; 207(8):1757-73. Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA. PMID: 20624892; PMCID: PMC2916124.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    47. The B-Cell Antigen Receptor. Topley \u0026 Wilson\u0027s Microbiology and Microbial Infections. 2010 Mar 15. DeFranco DA. .
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    48. Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice. Eur J Immunol. 2010 Feb; 40(2):539-47. Mamchak AA, Thien CB, Dagger SA, Lyandres J, Jiang S, Langdon WY, DeFranco AL. PMID: 19904769; PMCID: PMC2976765.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol. 2009 May 01; 182(9):5382-92. Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL. PMID: 19380785; PMCID: PMC2840041.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    50. "Dangerous crystals". Immunity. 2008 Nov 14; 29(5):670-1. DeFranco AL. PMID: 19006690.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    51. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol. 2008 Oct 15; 181(8):5374-85. Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL. PMID: 18832694; PMCID: PMC2657555.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    52. Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity. 2008 Aug 15; 29(2):272-82. Hou B, Reizis B, DeFranco AL. PMID: 18656388; PMCID: PMC2847796.
      View in: PubMed   Mentions: 200     Fields:    Translation:AnimalsCells
    53. Lipid rafts and B cell signaling. Semin Cell Dev Biol. 2007 Oct; 18(5):616-26. Gupta N, DeFranco AL. PMID: 17719248; PMCID: PMC2169358.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    54. Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics. Nat Immunol. 2006 Jun; 7(6):625-33. Gupta N, Wollscheid B, Watts JD, Scheer B, Aebersold R, DeFranco AL. PMID: 16648854.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    55. TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J Biol Chem. 2005 Nov 04; 280(44):37107-17. Nishiya T, Kajita E, Miwa S, Defranco AL. PMID: 16105838.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansAnimalsCells
    56. Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood. 2005 Sep 15; 106(6):2105-12. Tian MT, Gonzalez G, Scheer B, DeFranco AL. PMID: 15878976; PMCID: PMC1895143.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    57. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem. 2004 Apr 30; 279(18):19008-17. Nishiya T, DeFranco AL. PMID: 14976215.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    58. Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell. 2003 Feb; 14(2):432-44. Gupta N, DeFranco AL. PMID: 12589045; PMCID: PMC149983.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    59. Vav and the B cell signalosome. Nat Immunol. 2001 Jun; 2(6):482-4. DeFranco AL. PMID: 11376331.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    60. Apoptosis induced by the antigen receptor and Fas in a variant of the immature B cell line WEHI-231 and in splenic immature B cells. Int Immunol. 2001 Apr; 13(4):581-92. Tian MT, Chou CH, DeFranco AL. PMID: 11282997.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    61. Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen. J Immunol. 2001 Mar 15; 166(6):3855-64. Richards JD, Davé SH, Chou CH, Mamchak AA, DeFranco AL. PMID: 11238629.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    62. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr Biol. 2001 Jan 09; 11(1):34-8. Yu CC, Yen TS, Lowell CA, DeFranco AL. PMID: 11166177.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    63. B-cell activation 2000. Immunol Rev. 2000 Aug; 176:5-9. DeFranco AL. PMID: 11043763.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    64. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity. 2000 Jul; 13(1):47-57. Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF. PMID: 10933394.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    65. Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta. J Leukoc Biol. 2000 Mar; 67(3):405-14. Weinstein SL, Finn AJ, Davé SH, Meng F, Lowell CA, Sanghera JS, DeFranco AL. PMID: 10733102.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    66. Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J Exp Med. 2000 Feb 21; 191(4):669-82. Fitzer-Attas CJ, Lowry M, Crowley MT, Finn AJ, Meng F, DeFranco AL, Lowell CA. PMID: 10684859; PMCID: PMC2195832.
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    67. Cell signaling and cytokine induction by lipopolysaccharide. Novel Cytokine Inhibitors. 2000 Jan 1; 9-42. MacKichan MM, DeFranco DA. .
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    68. The src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes. J Biol Chem. 1999 Apr 23; 274(17):12183-91. Harmer SL, DeFranco AL. PMID: 10207047.
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    69. Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog. J Biol Chem. 1999 Jan 15; 274(3):1767-75. MacKichan ML, DeFranco AL. PMID: 9880559.
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    70. Positive and negative roles of the tyrosine kinase Lyn in B cell function. Semin Immunol. 1998 Aug; 10(4):299-307. DeFranco AL, Chan VW, Lowell CA. PMID: 9695186.
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    71. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol. 1998 May 07; 8(10):545-53. Chan VW, Lowell CA, DeFranco AL. PMID: 9601638.
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    72. The role of tyrosine kinases and map kinases in LPS-induced signaling. Prog Clin Biol Res. 1998; 397:119-36. DeFranco AL, Crowley MT, Finn A, Hambleton J, Weinstein SL. PMID: 9575553.
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    73. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med. 1997 Oct 06; 186(7):1027-39. Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL. PMID: 9314552; PMCID: PMC2199061.
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    74. Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes. Mol Cell Biol. 1997 Jul; 17(7):4087-95. Harmer SL, DeFranco AL. PMID: 9199344; PMCID: PMC232262.
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    75. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997 Jul; 7(1):69-81. Chan VW, Meng F, Soriano P, DeFranco AL, Lowell CA. PMID: 9252121.
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    76. The complexity of signaling pathways activated by the BCR. Curr Opin Immunol. 1997 Jun; 9(3):296-308. DeFranco AL. PMID: 9203421.
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    77. Receptor tails unlock developmental checkpoints for B lymphocytes. Science. 1996 Jun 21; 272(5269):1752-4. Roth PE, DeFranco AL. PMID: 8650572.
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    78. The two-headed antigen. B-cell co-receptors. Curr Biol. 1996 May 01; 6(5):548-50. DeFranco AL. PMID: 8805272.
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    79. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):2774-8. Hambleton J, Weinstein SL, Lem L, DeFranco AL. PMID: 8610116; PMCID: PMC39708.
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    80. Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. J Biol Chem. 1996 Mar 15; 271(11):6458-66. Richards JD, Gold MR, Hourihane SL, DeFranco AL, Matsuuchi L. PMID: 8626447.
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    81. Assembly of the truncated immunoglobulin heavy chain D mu into antigen receptor-like complexes in pre-B cells but not in B cells. Immunity. 1996 Feb; 4(2):145-58. Horne MC, Roth PE, DeFranco AL. PMID: 8624805.
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    82. Activation-induced association of a 145-kDa tyrosine-phosphorylated protein with Shc and Syk in B lymphocytes and macrophages. J Biol Chem. 1996 Jan 12; 271(2):1145-52. Crowley MT, Harmer SL, DeFranco AL. PMID: 8557643.
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    83. Signal transduction by the B-cell antigen receptor. Ann N Y Acad Sci. 1995 Sep 07; 766:195-201. DeFranco AL, Richards JD, Blum JH, Stevens TL, Law DA, Chan VW, Datta SK, Foy SP, Hourihane SL, Gold MR, et al. PMID: 7486656.
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    84. Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events. J Exp Med. 1995 Jul 01; 182(1):147-54. Hambleton J, McMahon M, DeFranco AL. PMID: 7790814; PMCID: PMC2192101.
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    85. Tyrosine phosphatases and the antibody response. Science. 1995 Apr 14; 268(5208):263-4. DeFranco AL, Law DA. PMID: 7716518.
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    86. Transmembrane signaling by antigen receptors of B and T lymphocytes. Curr Opin Cell Biol. 1995 Apr; 7(2):163-75. DeFranco AL. PMID: 7612267.
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    87. Lymphocyte development. Intrinsic checkpoints for lineage progression. Curr Biol. 1995 Apr 01; 5(4):349-52. Roth PE, DeFranco AL. PMID: 7627545.
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    88. Examination of the role of MAP kinase in the response of macrophages to lipopolysaccharide. Prog Clin Biol Res. 1995; 392:407-20. DeFranco AL, Hambleton J, McMahon M, Weinstein SL. PMID: 8524948.
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    89. Lymphocyte activation and effector functions Editorial overview. Current Opinion in Immunology. 1995 Jan 1; 7(3):303-305. DeFranco DA, Coffman CR. .
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    90. Structure and Function of the B-Cell Antigen Receptor. Lymphocyte Activation. 1994 Aug 23; 59:156-172. DeFranco DA, Blum BJ, Stevens ST, Law LD, Chan CV, Foy FS, Datta DS, Matsuuchi ML. .
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    91. Signaling pathways activated by protein tyrosine phosphorylation in lymphocytes. Curr Opin Immunol. 1994 Jun; 6(3):364-71. DeFranco AL. PMID: 7917103.
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    92. A mutation of the mu transmembrane that disrupts endoplasmic reticulum retention. Effects on association with accessory proteins and signal transduction. J Immunol. 1994 May 01; 152(9):4397-406. Stevens TL, Blum JH, Foy SP, Matsuuchi L, DeFranco AL. PMID: 8157960.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    93. Mechanism of B cell antigen receptor function: transmembrane signaling and triggering of apoptosis. Adv Exp Med Biol. 1994; 365:9-22. DeFranco AL, Mittelstadt PR, Blum JH, Stevens TL, Law DA, Chan VW, Foy SP, Datta SK, Matsuuchi L. PMID: 7887317.
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    94. Structure and function of the B-cell antigen receptor. Chem Immunol. 1994; 59:156-72. DeFranco AL, Blum JH, Stevens TL, Law DA, Chan VW, Foy SP, Datta SK, Matsuuchi L. PMID: 7945925.
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    95. Biochemistry of B lymphocyte activation. Adv Immunol. 1994; 55:221-95. Gold MR, DeFranco AL. PMID: 8304234.
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    96. Role of the mu immunoglobulin heavy chain transmembrane and cytoplasmic domains in B cell antigen receptor expression and signal transduction. J Biol Chem. 1993 Dec 25; 268(36):27236-45. Blum JH, Stevens TL, DeFranco AL. PMID: 8262964.
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    97. B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn. Curr Biol. 1993 Oct 01; 3(10):645-57. Law DA, Chan VW, Datta SK, DeFranco AL. PMID: 15335855.
      View in: PubMed   Mentions: 28     Fields:    
    98. Signaling the insulin receptor way. Curr Biol. 1993 Oct 01; 3(10):713-5. DeFranco AL. PMID: 15335869.
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    99. Lipopolysaccharide-induced protein tyrosine phosphorylation in human macrophages is mediated by CD14. J Immunol. 1993 Oct 01; 151(7):3829-38. Weinstein SL, June CH, DeFranco AL. PMID: 7690817.
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    100. Stimulation of kappa light-chain gene rearrangement by the immunoglobulin mu heavy chain in a pre-B-cell line. Mol Cell Biol. 1993 Sep; 13(9):5679-90. Shapiro AM, Schlissel MS, Baltimore D, DeFranco AL. PMID: 8355709; PMCID: PMC360301.
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    101. Stimulation of kappa light-chain gene rearrangement by the immunoglobulin mu heavy chain in a pre-B-cell line. Molecular and Cellular Biology. 1993 Sep 1; 13(9):5679-5690. Shapiro SA, Schlissel SM, Baltimore BD, DeFranco DA. .
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    102. Induction of early response genes by cross-linking membrane Ig on B lymphocytes. J Immunol. 1993 Jun 01; 150(11):4822-32. Mittelstadt PR, DeFranco AL. PMID: 8388422.
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    103. Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins. J Immunol. 1993 Jan 15; 150(2):377-86. Gold MR, Crowley MT, Martin GA, McCormick F, DeFranco AL. PMID: 8419471.
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    104. Structure and function of the B cell antigen receptor. Annu Rev Cell Biol. 1993; 9:377-410. DeFranco AL. PMID: 8280466.
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    105. Tyrosine phosphorylation and the mechanism of signal transduction by the B-lymphocyte antigen receptor. EJB Reviews. 1993 Jan 1; 245-252. Defranco DA. .
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    106. Tyrosine phosphorylation and the mechanism of signal transduction by the B-lymphocyte antigen receptor. Eur J Biochem. 1992 Dec 01; 210(2):381-8. DeFranco AL. PMID: 1281096.
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    107. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J Biol Chem. 1992 Jul 25; 267(21):14955-62. Weinstein SL, Sanghera JS, Lemke K, DeFranco AL, Pelech SL. PMID: 1321821.
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    108. Examination of B lymphoid cell lines for membrane immunoglobulin-stimulated tyrosine phosphorylation and src-family tyrosine kinase mRNA expression. Mol Immunol. 1992 Jul-Aug; 29(7-8):917-26. Law DA, Gold MR, DeFranco AL. PMID: 1378935.
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    109. Tyrosine phosphorylation of phospholipase C-gamma 2 upon cross-linking of membrane Ig on murine B lymphocytes. J Immunol. 1992 May 15; 148(10):3021-7. Hempel WM, Schatzman RC, DeFranco AL. PMID: 1578127.
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    110. Autoimmunity. Hidden lymphocytes. Nature. 1992 May 07; 357(6373):14-5. DeFranco AL. PMID: 1574123.
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    111. The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3404-8. Matsuuchi L, Gold MR, Travis A, Grosschedl R, DeFranco AL, Kelly RB. PMID: 1373499; PMCID: PMC48876.
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    112. Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes. J Immunol. 1992 Apr 01; 148(7):2012-22. Gold MR, Chan VW, Turck CW, DeFranco AL. PMID: 1372019.
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    113. bcl-2 to the rescue. Curr Biol. 1992 Feb; 2(2):95-7. DeFranco AL. PMID: 15336006.
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    114. Regulation of anti-immunoglobulin-induced B lymphoma growth arrest by transforming growth factor beta 1 and dexamethasone. Int Immunol. 1991 Nov; 3(11):1091-8. Gold MR, Gajewski TF, DeFranco AL. PMID: 1760404.
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    115. All about B cells. Cancer Cells. 1991 Nov; 3(11):450-3. DeFranco AL. PMID: 1760246.
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    116. Signal transduction. Immunosuppressants at work. Nature. 1991 Aug 29; 352(6338):754-5. DeFranco AL. PMID: 1715515.
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    117. Between B cells and T cells. Nature. 1991 Jun 20; 351(6328):603-4. DeFranco AL. PMID: 1675766.
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    118. Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 01; 146(11):3713-20. Hempel WM, DeFranco AL. PMID: 2033248.
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    119. Bacterial lipopolysaccharide stimulates protein tyrosine phosphorylation in macrophages. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4148-52. Weinstein SL, Gold MR, DeFranco AL. PMID: 1709735; PMCID: PMC51615.
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    120. Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):3436-40. Gold MR, Matsuuchi L, Kelly RB, DeFranco AL. PMID: 1707541; PMCID: PMC51462.
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    121. Mutational analysis of antigen receptor regulation of B lymphocyte growth. Evidence for involvement of the phosphoinositide signaling pathway. J Biol Chem. 1991 Mar 25; 266(9):5563-74. Page DM, Gold MR, Fahey KA, Matsuuchi L, DeFranco AL. PMID: 1848555.
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    122. Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor. Nature. 1990 Jun 28; 345(6278):810-3. Gold MR, Law DA, DeFranco AL. PMID: 1694265.
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    123. Antigen receptor-induced cell cycle arrest in WEHI-231 B lymphoma cells depends on the duration of signaling before the G1 phase restriction point. Mol Cell Biol. 1990 Jun; 10(6):3003-12. Page DM, DeFranco AL. PMID: 2342467; PMCID: PMC360664.
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    124. Antigen receptor-induced cell cycle arrest in WEHI-231 B lymphoma cells depends on the duration of signaling before the G1 phase restriction point. Molecular and Cellular Biology. 1990 Jun 1; 10(6):3003-3012. Page PD, DeFranco DA. .
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    125. Antigen Receptor-Induced Cell Cycle Arrest in WEHI-231 B Lymphoma Cells Depends on the Duration of Signaling before the G1 Phase Restriction Point. Molecular and Cellular Biology. 1990 Jun 1; 10(6):3003-3012. Page PD, Defranco DA. .
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    126. Immunology. Tolerance: a second mechanism. Nature. 1989 Nov 23; 342(6248):340-1. DeFranco AL. PMID: 2586604.
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    127. B lymphocytes in human disease edited by Graham Bird and Jane E. Calvert, Oxford Medical Publications, 1988. £55.00 (xxviii + 513 pages) ISBN 0 19 2615734. Trends in Immunology. 1989 May 1; 10(5):176. DeFranco DA. .
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    128. Signal transduction via the B cell antigen receptor: involvement of a G protein and regulation of signaling. Adv Exp Med Biol. 1989; 254:101-12. DeFranco AL, Gold MR. PMID: 2554695.
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    129. Signal transduction by the antigen receptor of B lymphocytes. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 2:733-40. DeFranco AL, Page DM, Blum JH, Gold MR. PMID: 2561805.
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    130. Fate of self-reactive B cells. Nature. 1988 Aug 25; 334(6184):652-3. DeFranco AL. PMID: 3261840.
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    131. Cell-cell interactions in the antibody response. Nature. 1988 Jul 21; 334(6179):199-200. DeFranco AL. PMID: 2969459.
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    132. Role of phosphoinositide-derived second messengers in mediating anti-IgM-induced growth arrest of WEHI-231 B lymphoma cells. J Immunol. 1988 Jun 01; 140(11):3717-26. Page DM, DeFranco AL. PMID: 2836499.
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    133. Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown. J Immunol. 1987 Dec 01; 139(11):3604-13. Gold MR, Jakway JP, DeFranco AL. PMID: 2824610.
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    134. Cross-linking membrane IgM induces production of inositol trisphosphate and inositol tetrakisphosphate in WEHI-231 B lymphoma cells. J Immunol. 1987 Jun 01; 138(11):3935-42. Fahey KA, DeFranco AL. PMID: 3035017.
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    135. Phorbol esters and dioctanoylglycerol block anti-IgM-stimulated phosphoinositide hydrolysis in the murine B cell lymphoma WEHI-231. J Immunol. 1987 Feb 01; 138(3):868-76. Gold MR, DeFranco AL. PMID: 3027166.
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    136. B-lymphocyte signal transduction in response to anti-immunoglobulin and bacterial lipopolysaccharide. Immunol Rev. 1987 Feb; 95:161-76. DeFranco AL, Gold MR, Jakway JP. PMID: 3032773.
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    137. Molecular aspects of B-lymphocyte activation. Annu Rev Cell Biol. 1987; 3:143-78. DeFranco AL. PMID: 2961351.
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    138. Transmembrane signaling reactions generated in B cells in response to anti-IgM or lipopolysaccharide. Adv Exp Med Biol. 1987; 213:189-93. DeFranco AL. PMID: 3498297.
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    139. Pertussis toxin inhibition of B cell and macrophage responses to bacterial lipopolysaccharide. Science. 1986 Nov 07; 234(4777):743-6. Jakway JP, DeFranco AL. PMID: 3095921.
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    140. Growth regulation of the B lymphoma cell line WEHI-231 by anti-immunoglobulin, lipopolysaccharide, and other bacterial products. J Immunol. 1986 Oct 01; 137(7):2225-31. Jakway JP, Usinger WR, Gold MR, Mishell RI, DeFranco AL. PMID: 3489760.
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    141. Stimulation of the antigen receptor on WEHI-231 B lymphoma cells results in a voltage-independent increase in cytoplasmic calcium. J Immunol. 1986 Sep 15; 137(6):1836-44. LaBaer J, Tsien RY, Fahey KA, DeFranco AL. PMID: 2427581.
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    142. Separate control of B lymphocyte early activation and proliferation in response to anti-IgM antibodies. J Immunol. 1985 Jul; 135(1):87-94. DeFranco AL, Raveche ES, Paul WE. PMID: 3873499.
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    143. Can resting B cells present antigen to T cells? Fed Proc. 1985 May; 44(8):2475-9. Ashwell JD, DeFranco AL, Paul WE, Schwartz RH. PMID: 3886434.
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    144. Polyclonal stimulation of resting B lymphocytes by antigen-specific T lymphocytes. J Exp Med. 1984 Mar 01; 159(3):861-80. DeFranco AL, Ashwell JD, Schwartz RH, Paul WE. PMID: 6199453; PMCID: PMC2187247.
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    145. Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation. J Exp Med. 1984 Mar 01; 159(3):881-905. Ashwell JD, DeFranco AL, Paul WE, Schwartz RH. PMID: 6607969; PMCID: PMC2187250.
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    146. Growth regulation of a B-cell lymphoma via the antigen receptor. Curr Top Microbiol Immunol. 1984; 113:92-5. DeFranco AL. PMID: 6332723.
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    147. Cell cycle analysis of lymphocyte activation in normal and autoimmune strains of mice. J Immunol. 1982 Sep; 129(3):1219-26. Raveche ES, Steinberg AD, DeFranco AL, Tjio JH. PMID: 6125541.
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    148. Frequency of B lymphocytes responsive to anti-immunoglobulin. J Exp Med. 1982 May 01; 155(5):1523-36. Defranco AL, Raveche ES, Asofsky R, Paul WE. PMID: 6802927; PMCID: PMC2186672.
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    149. Long term growth of B-lymphocytes. Ann N Y Acad Sci. 1982; 399:105-11. Paul WE, DeFranco A, Sredni B, Howard M. PMID: 6984599.
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    150. Regulation of growth and proliferation in B cell subpopulations. Immunol Rev. 1982; 64:161-82. DeFranco AL, Kung JT, Paul WE. PMID: 6806172.
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