Frank McCormick, PhD, FRS

Title(s)Professor, HDF Comprehensive Cancer Ctr
SchoolSchool of Medicine
Address1450 Third St, #371
San Francisco CA 94158
Phone415-502-1707
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    Collapse Overview
    Frank McCormick, PhD, FRS, is a Professor in the UCSF Helen Diller Family Comprehensive Cancer Center. Prior to joining the UCSF faculty, Dr. McCormick pursued cancer-related work with several Bay Area biotechnology firms and held positions with Cetus Corporation (Director of Molecular Biology, 1981-1990; Vice President of Research, 1990-1991) and Chiron Corporation, where he was Vice President of Research from 1991 to 1992. In 1992 he founded Onyx Pharmaceuticals, a company dedicated to developing new cancer therapies, and served as its Chief Scientific Officer until 1996. At Onyx Pharmaceuticals, he initiated and led drug discovery efforts that led to the approval of Sorafenib in 2005 for treatment of renal cell cancer, and for liver cancer in 2007, and the approval of ONYX-015 in 2006 in China for treatment of nasopharyngeal cancer. Sorafenib is being tested in multiple indications worldwide. In addition, Dr. McCormick’s group led to the identification of a CDK4 kinase inhibitor. Dr. McCormick's current research interests center on the fundamental differences between normal and cancer cells that can allow the discovery of novel therapeutic strategies.

    Dr. McCormick holds the David A. Wood Chair of Tumor Biology and Cancer Research at UCSF. Dr. McCormick is the author of over 285 scientific publications and holds 20 issued patents. He also served as President, 2012-2013 for the American Association for Cancer Research (AACR). More recently, he has taken a leadership role at the Frederick National Lab for Cancer Research, overseeing an NCI supported national effort to develop therapies against Ras-driven cancers. These cancers include most pancreatic cancers, and many colorectal and lung cancers, and are amongst the most difficult cancers to treat.

    Collapse Research 
    Collapse Research Activities and Funding
    Biodesy Delta System for San Francisco Bay Area Region
    NIH S10OD023482Mar 15, 2017 - Mar 14, 2018
    Role: Principal Investigator
    New Ways of Targeting K-Ras
    NIH R35CA197709Apr 1, 2016 - Mar 31, 2023
    Role: Principal Investigator
    Bay Area Cancer Target Discovery and Development Network
    NIH U01CA168370May 1, 2012 - Apr 30, 2017
    Role: Co-Principal Investigator
    Cancer Center Support Grant
    NIH P30CA082103Aug 5, 1999 - May 31, 2023
    Role: Co-Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Anal Chem. 2024 Mar 18. D'Ippolito RA, Rabara D, Blanco MA, Alberico E, Drew MR, Ramakrishnan N, Sontan D, Widmeyer SRT, Scheidemantle GM, Messing S, Turner D, Arkin M, Maciag AE, Stephen AG, Esposito D, McCormick F, Nissley DV, DeHart CJ. PMID: 38498381.
      View in: PubMed   Mentions:    Fields:    
    2. Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Commun Biol. 2024 Mar 02; 7(1):260. Finci LI, Chakrabarti M, Gulten G, Finney J, Grose C, Fox T, Yang R, Nissley DV, McCormick F, Esposito D, Balius TE, Simanshu DK. PMID: 38431713; PMCID: PMC10908828.
      View in: PubMed   Mentions: Translation:HumansCells
    3. Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties. Sci Adv. 2024 Feb 16; 10(7):eadj4137. Whitley MJ, Tran TH, Rigby M, Yi M, Dharmaiah S, Waybright TJ, Ramakrishnan N, Perkins S, Taylor T, Messing S, Esposito D, Nissley DV, McCormick F, Stephen AG, Turbyville T, Cornilescu G, Simanshu DK. PMID: 38354232.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR. J Biol Chem. 2024 Feb; 300(2):105650. Sharma AK, Pei J, Yang Y, Dyba M, Smith B, Rabara D, Larsen EK, Lightstone FC, Esposito D, Stephen AG, Wang B, Beltran PJ, Wallace E, Nissley DV, McCormick F, Maciag AE. PMID: 38237681; PMCID: PMC10877953.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance. Nat Commun. 2024 Jan 12; 15(1):477. Vasudevan HN, Payne E, Delley CL, John Liu S, Mirchia K, Sale MJ, Lastella S, Nunez MS, Lucas CG, Eaton CD, Casey-Clyde T, Magill ST, Chen WC, Braunstein SE, Perry A, Jacques L, Reddy AT, Pekmezci M, Abate AR, McCormick F, Raleigh DR. PMID: 38216572; PMCID: PMC10786885.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. Progress in Targeting KRAS Directly. Methods Mol Biol. 2024; 2797:1-12. Nissley DV, Stephen AG, Yi M, McCormick F. PMID: 38570448.
      View in: PubMed   Mentions:    Fields:    
    7. Long-term ecological research in freshwaters enabled by regional biodiversity collections, stable isotope analysis, and environmental informatics. Bioscience. 2023 Jul 29; 73(7):479-493. Turner TF, Bart HL, McCormick F, Besser AC, Bowes RE, Capps KA, DeArmon ES, Dillman CB, Driscoll KP, Dugger A, Hamilton GL, Harris PM, Hendrickson DA, Hoffman J, Knouft JH, Lepak RF, López-Fernández H, Montaña CG, Newsome SD, Pease AA, Smith WL, Taylor CA, Welicky RL. PMID: 37841229; PMCID: PMC10569117.
      View in: PubMed   Mentions:    Fields:    
    8. RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy. Sci Adv. 2023 07 14; 9(28):eadf4766. Cuevas-Navarro A, Wagner M, Van R, Swain M, Mo S, Columbus J, Allison MR, Cheng A, Messing S, Turbyville TJ, Simanshu DK, Sale MJ, McCormick F, Stephen AG, Castel P. PMID: 37450595; PMCID: PMC10348673.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D. Commun Biol. 2023 06 02; 6(1):594. Chao FA, Chan AH, Dharmaiah S, Schwieters CD, Tran TH, Taylor T, Ramakrishnan N, Esposito D, Nissley DV, McCormick F, Simanshu DK, Cornilescu G. PMID: 37268708; PMCID: PMC10238545.
      View in: PubMed   Mentions: Translation:Cells
    10. RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights. J Invest Dermatol. 2023 08; 143(8):1358-1368. Rhodes SD, McCormick F, Cagan RL, Bakker A, Staedtke V, Ly I, Steensma MR, Lee SY, Romo CG, Blakeley JO, Sarin KY. PMID: 37245145; PMCID: PMC10409534.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling. J Biol Chem. 2023 06; 299(6):104789. Lopez J, Bonsor DA, Sale MJ, Urisman A, Mehalko JL, Cabanski-Dunning M, Castel P, Simanshu DK, McCormick F. PMID: 37149146; PMCID: PMC10248553.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    12. Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Proc Natl Acad Sci U S A. 2023 Jan 31; 120(5):e2208960120. Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A, Drew M, Darling J, Wall V, Grisshammer R, Cheng A, Allison MR, Sale MJ, Nissley DV, Esposito D, Ognjenovic J, McCormick F. PMID: 36689660; PMCID: PMC9945959.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. Cancer Discov. 2022 10 05; 12(10):2434-2453. Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, Durham BH, Pavletich TS, Fiala E, Walsh MF, Inoue D, Monette S, Taylor J, Rosen N, McCormick F, Lindsley RC, Castel P, Abdel-Wahab O. PMID: 35904492; PMCID: PMC9533010.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    14. Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Nat Struct Mol Biol. 2022 10; 29(10):966-977. Bonsor DA, Alexander P, Snead K, Hartig N, Drew M, Messing S, Finci LI, Nissley DV, McCormick F, Esposito D, Rodriguez-Viciana P, Stephen AG, Simanshu DK. PMID: 36175670; PMCID: PMC10365013.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells. Metabolites. 2022 Sep 02; 12(9). Kim SH, Song JH, Kim MJ, Song MG, Ku AA, Bandyopadhyay S, McCormick F, Kim SE. PMID: 36144235; PMCID: PMC9502772.
      View in: PubMed   Mentions:
    16. Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature. 2022 09; 609(7926):408-415. Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ. PMID: 35831509; PMCID: PMC9694338.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    17. ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. Mol Cell. 2022 07 07; 82(13):2443-2457.e7. Su W, Mukherjee R, Yaeger R, Son J, Xu J, Na N, Merna Timaul N, Hechtman J, Paroder V, Lin M, Mattar M, Qiu J, Chang Q, Zhao H, Zhang J, Little M, Adachi Y, Han SW, Taylor BS, Ebi H, Abdel-Wahab O, de Stanchina E, Rudin CM, Jänne PA, McCormick F, Yao Z, Rosen N. PMID: 35613620; PMCID: PMC9271631.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    18. Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs. Elife. 2022 04 25; 11. Cuevas-Navarro A, Rodriguez-Muñoz L, Grego-Bessa J, Cheng A, Rauen KA, Urisman A, McCormick F, Jimenez G, Castel P. PMID: 35467524; PMCID: PMC9068208.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    19. Targeting CD70 in cutaneous T-cell lymphoma using an antibody-drug conjugate in patient-derived xenograft models. Blood Adv. 2022 04 12; 6(7):2290-2302. Wu CH, Wang L, Yang CY, Wen KW, Hinds B, Gill R, McCormick F, Moasser M, Pincus L, Ai WZ. PMID: 34872108; PMCID: PMC9006301.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    20. RAS at 40: Update from the RAS Initiative. Cancer Discov. 2022 04 01; 12(4):895-898. Nissley DV, McCormick F. PMID: 35046096.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    21. More to the RAS Story: KRASG12C Inhibition, Resistance Mechanisms, and Moving Beyond KRASG12C. Am Soc Clin Oncol Educ Book. 2022 Apr; 42:1-13. Lietman CD, Johnson ML, McCormick F, Lindsay CR. PMID: 35561303.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    22. Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics. J Am Chem Soc. 2022 03 09; 144(9):4196-4205. Chao FA, Dharmaiah S, Taylor T, Messing S, Gillette W, Esposito D, Nissley DV, McCormick F, Byrd RA, Simanshu DK, Cornilescu G. PMID: 35213144; PMCID: PMC10430694.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors. Proc Natl Acad Sci U S A. 2022 02 01; 119(5). Lai LP, Fer N, Burgan W, Wall VE, Xu B, Soppet D, Esposito D, Nissley DV, McCormick F. PMID: 35091470; PMCID: PMC8812530.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    24. Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins. Proc Natl Acad Sci U S A. 2022 01 04; 119(1). Ingólfsson HI, Neale C, Carpenter TS, Shrestha R, López CA, Tran TH, Oppelstrup T, Bhatia H, Stanton LG, Zhang X, Sundram S, Di Natale F, Agarwal A, Dharuman G, Kokkila Schumacher SIL, Turbyville T, Gulten G, Van QN, Goswami D, Jean-Francois F, Agamasu C, Hettige JJ, Travers T, Sarkar S, Surh MP, Yang Y, Moody A, Liu S, Van Essen BC, Voter AF, Ramanathan A, Hengartner NW, Simanshu DK, Stephen AG, Bremer PT, Gnanakaran S, Glosli JN, Lightstone FC, McCormick F, Nissley DV, Streitz FH. PMID: 34983849; PMCID: PMC8740753.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    25. Cost Structures of US Organ Procurement Organizations. Transplantation. 2021 12 01; 105(12):2612-2619. Held PJ, Bragg-Gresham JL, Peters TG, McCormick F, Chertow G, Vaughan WP, Roberts JP. PMID: 33988344.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. NMR 1H, 13C, 15N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation. Biomol NMR Assign. 2022 04; 16(1):1-8. Sharma AK, Dyba M, Tonelli M, Smith B, Gillette WK, Esposito D, Nissley DV, McCormick F, Maciag AE. PMID: 34686998; PMCID: PMC9068649.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    27. A brief history of RAS and the RAS Initiative. Adv Cancer Res. 2022; 153:1-27. McCormick F. PMID: 35101227.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    28. RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity. Proc Natl Acad Sci U S A. 2021 08 17; 118(33). Castel P, Dharmaiah S, Sale MJ, Messing S, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D, Simanshu DK, McCormick F. PMID: 34380736; PMCID: PMC8379911.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    29. UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). Wolfe AL, Zhou Q, Toska E, Galeas J, Ku AA, Koche RP, Bandyopadhyay S, Scaltriti M, Lebrilla CB, McCormick F, Kim SE. PMID: 34330832; PMCID: PMC8346792.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    30. Inhibition of MET Signaling with Ficlatuzumab in Combination with Chemotherapy in Refractory AML: Clinical Outcomes and High-Dimensional Analysis. Blood Cancer Discov. 2021 09; 2(5):434-449. Wang VE, Blaser BW, Patel RK, Behbehani GK, Rao AA, Durbin-Johnson B, Jiang T, Logan AC, Settles M, Mannis GN, Olin R, Damon LE, Martin TG, Sayre PH, Gaensler KM, McMahon E, Flanders M, Weinberg V, Ye CJ, Carbone DP, Munster PN, Fragiadakis GK, McCormick F, Andreadis C. PMID: 34514432; PMCID: PMC8425277.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    31. A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness. Front Cell Dev Biol. 2021; 9:665673. Okutachi S, Manoharan GB, Kiriazis A, Laurini C, Catillon M, McCormick F, Yli-Kauhaluoma J, Abankwa D. PMID: 34307350; PMCID: PMC8296985.
      View in: PubMed   Mentions: 5  
    32. The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. Curr Biol. 2021 09 13; 31(17):3915-3924.e9. Cuevas-Navarro A, Van R, Cheng A, Urisman A, Castel P, McCormick F. PMID: 34237269; PMCID: PMC8440430.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    33. Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Cell Rep Methods. 2021 07 26; 1(3). Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. PMID: 34671754; PMCID: PMC8525888.
      View in: PubMed   Mentions: 2  Translation:Humans
    34. Estimated impact of novel coronavirus-19 and transplant center inactivity on end-stage renal disease-related patient mortality in the United States. Clin Transplant. 2021 08; 35(8):e14292. Peters TG, Bragg-Gresham JL, Klopstock AC, Roberts JP, Chertow G, McCormick F, Held PJ. PMID: 33749935; PMCID: PMC8250232.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    35. RAS-targeted therapies. Nat Rev Drug Discov. 2021 May 14. Moore AR, Rosenberg SC, McCormick F, Malek S. PMID: 33990767.
      View in: PubMed   Mentions: 4     Fields:    
    36. Sensitivity of Oncogenic KRAS-Expressing Cells to CDK9 Inhibition. SLAS Discov. 2021 08; 26(7):922-932. Lai LP, Brel V, Sharma K, Frappier J, Le-Henanf N, Vivet B, Muzet N, Schell E, Morales R, Rooney E, Basse N, Yi M, Lacroix F, Holderfield M, Englaro W, Marcireau C, Debussche L, Nissley DV, McCormick F. PMID: 33896272; PMCID: PMC8791284.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    37. Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nat Genet. 2021 05; 53(5):707-718. Inoue D, Polaski JT, Taylor J, Castel P, Chen S, Kobayashi S, Hogg SJ, Hayashi Y, Pineda JMB, El Marabti E, Erickson C, Knorr K, Fukumoto M, Yamazaki H, Tanaka A, Fukui C, Lu SX, Durham BH, Liu B, Wang E, Mehta S, Zakheim D, Garippa R, Penson A, Chew GL, McCormick F, Bradley RK, Abdel-Wahab O. PMID: 33846634; PMCID: PMC8177065.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    38. The Metabolic Landscape of RAS-Driven Cancers from biology to therapy. Nat Cancer. 2021 03; 2(3):271-283. Mukhopadhyay S, Vander Heiden MG, McCormick F. PMID: 33870211; PMCID: PMC8045781.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    39. Correction: DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs. J Biol Chem. 2021 Jan-Jun; 296:100380. Castel P, Holtz-Morris A, Kwon Y, Suter BP, McCormick F. PMID: 33837738; PMCID: PMC7949137.
      View in: PubMed   Mentions:    Fields:    
    40. KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun. 2021 02 19; 12(1):1176. Tran TH, Chan AH, Young LC, Bindu L, Neale C, Messing S, Dharmaiah S, Taylor T, Denson JP, Esposito D, Nissley DV, Stephen AG, McCormick F, Simanshu DK. PMID: 33608534; PMCID: PMC7895934.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    41. Author Correction: RAS-targeted therapies: is the undruggable drugged? Nat Rev Drug Discov. 2020 Dec; 19(12):902. Moore AR, Rosenberg SC, McCormick F, Malek S. PMID: 33082552.
      View in: PubMed   Mentions: 8     Fields:    
    42. Reducing the Shortage of Transplant Kidneys: A Lost Opportunity for the US Health Resources and Services Administration (HRSA). Am J Kidney Dis. 2021 06; 77(6):963-966. McCormick F, Held PJ, Chertow GM, Peters TG, Roberts JP. PMID: 33271212.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    43. DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs. J Biol Chem. 2021 Jan-Jun; 296:100023. Castel P, Holtz-Morris A, Kwon Y, Suter BP, McCormick F. PMID: 33410398; PMCID: PMC7949039.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    44. SPRED proteins and their roles in signal transduction, development, and malignancy. Genes Dev. 2020 11 01; 34(21-22):1410-1421. Lorenzo C, McCormick F. PMID: 33872193; PMCID: PMC7608746.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    45. Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway. Mol Syst Biol. 2020 10; 16(10):e9518. Gillies TE, Pargett M, Silva JM, Teragawa CK, McCormick F, Albeck JG. PMID: 33073539; PMCID: PMC7569415.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    46. Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24258-24268. Van QN, López CA, Tonelli M, Taylor T, Niu B, Stanley CB, Bhowmik D, Tran TH, Frank PH, Messing S, Alexander P, Scott D, Ye X, Drew M, Chertov O, Lösche M, Ramanathan A, Gross ML, Hengartner NW, Westler WM, Markley JL, Simanshu DK, Nissley DV, Gillette WK, Esposito D, McCormick F, Gnanakaran S, Heinrich F, Stephen AG. PMID: 32913056; PMCID: PMC7533834.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    47. The molecular functions of RIT1 and its contribution to human disease. Biochem J. 2020 08 14; 477(15):2755-2770. Van R, Cuevas-Navarro A, Castel P, McCormick F. PMID: 32766847; PMCID: PMC7787054.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    48. Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Rep. 2020 07 21; 32(3):107909. Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK. PMID: 32697994; PMCID: PMC7437355.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    49. Cutaneous T-Cell Lymphoma PDX Drug Screening Platform Identifies Cooperation between Inhibitions of PI3Kα/δ and HDAC. J Invest Dermatol. 2021 02; 141(2):364-373. Wu CH, Yang CY, Wang L, Gao HX, Rakhshandehroo T, Afghani S, Pincus L, Balassanian R, Rubenstein J, Gill R, Bandyopadhyay S, McCormick F, Moasser M, Ai WZ. PMID: 32603749; PMCID: PMC10286854.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    50. ssGSEA score-based Ras dependency indexes derived from gene expression data reveal potential Ras addiction mechanisms with possible clinical implications. Sci Rep. 2020 06 24; 10(1):10258. Yi M, Nissley DV, McCormick F, Stephens RM. PMID: 32581224; PMCID: PMC7314760.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCells
    51. RAS-targeted therapies: is the undruggable drugged? Nat Rev Drug Discov. 2020 08; 19(8):533-552. Moore AR, Rosenberg SC, McCormick F, Malek S. PMID: 32528145; PMCID: PMC7809886.
      View in: PubMed   Mentions: 307     Fields:    Translation:HumansAnimals
    52. Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility. Nat Commun. 2020 05 12; 11(1):2375. Ku AA, Hu HM, Zhao X, Shah KN, Kongara S, Wu D, McCormick F, Balmain A, Bandyopadhyay S. PMID: 32398776; PMCID: PMC7217969.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    53. The duality of human oncoproteins: drivers of cancer and congenital disorders. Nat Rev Cancer. 2020 07; 20(7):383-397. Castel P, Rauen KA, McCormick F. PMID: 32341551; PMCID: PMC7787056.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    54. The small molecule BI-2852 induces a nonfunctional dimer of KRAS. Proc Natl Acad Sci U S A. 2020 02 18; 117(7):3363-3364. Tran TH, Alexander P, Dharmaiah S, Agamasu C, Nissley DV, McCormick F, Esposito D, Simanshu DK, Stephen AG, Balius TE. PMID: 32047043; PMCID: PMC7035607.
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    117. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. Nat Rev Cancer. 2014 Jul; 14(7):455-67. Holderfield M, Deuker MM, McCormick F, McMahon M. PMID: 24957944; PMCID: PMC4250230.
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    119. Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell Metab. 2014 Apr 01; 19(4):694-701. Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR. PMID: 24703700; PMCID: PMC4294542.
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    122. Vemurafenib cooperates with HPV to promote initiation of cutaneous tumors. Cancer Res. 2014 Apr 15; 74(8):2238-45. Holderfield M, Lorenzana E, Weisburd B, Lomovasky L, Boussemart L, Lacroix L, Tomasic G, Favre M, Vagner S, Robert C, Ghoddusi M, Daniel D, Pryer N, McCormick F, Stuart D. PMID: 24523442.
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    127. High mobility group box 1 promotes tumor cell migration through epigenetic silencing of semaphorin 3A. Oncogene. 2014 Oct 30; 33(44):5151-62. Nehil M, Paquette J, Tokuyasu T, McCormick F. PMID: 24213571.
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    130. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell. 2013 Oct 14; 24(4):450-65. Timmerman LA, Holton T, Yuneva M, Louie RJ, Padró M, Daemen A, Hu M, Chan DA, Ethier SP, van 't Veer LJ, Polyak K, McCormick F, Gray JW. PMID: 24094812; PMCID: PMC3931310.
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    131. MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13845-50. Lyons J, Bastian BC, McCormick F. PMID: 23908401; PMCID: PMC3752210.
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    139. Promoting growth for preterm infants following hospital discharge. Arch Dis Child Fetal Neonatal Ed. 2012 Jul; 97(4):F295-8. Morgan JA, Young L, McCormick FM, McGuire W. PMID: 21406452.
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    146. The molecular pathology of cancer. Nat Rev Clin Oncol. 2010 May; 7(5):251-65. Harris TJ, McCormick F. PMID: 20351699.
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    149. How blocking Raf activates the MAPK pathway. Pigment Cell Melanoma Res. 2010 Apr; 23(2):187-9. McCormick F. PMID: 20128874.
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    158. Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR. Leukemia. 2009 Feb; 23(2):396-9. Oehler VG, Qin J, Ramakrishnan R, Facer G, Ananthnarayan S, Cummings C, Deininger M, Shah N, McCormick F, Willis S, Daridon A, Unger M, Radich JP. PMID: 18615105; PMCID: PMC3655797.
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    159. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. Oncogene. 2008 Sep 11; 27(40):5303-14. Kitagawa M, Aonuma M, Lee SH, Fukutake S, McCormick F. PMID: 18521084.
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    160. An analysis of the rotator interval in patients with anterior, posterior, and multidirectional shoulder instability. Arthroscopy. 2008 Aug; 24(8):921-9. Provencher MT, Dewing CB, Bell SJ, McCormick F, Solomon DJ, Rooney TB, Stanley M. PMID: 18657741.
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    162. Combinatorial patterns of somatic gene mutations in cancer. FASEB J. 2008 Aug; 22(8):2605-22. Yeang CH, McCormick F, Levine A. PMID: 18434431.
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    165. Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy. PLoS One. 2007 Dec 05; 2(12):e1279. Estep AL, Palmer C, McCormick F, Rauen KA. PMID: 18060073; PMCID: PMC2093994.
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    166. Polycystic kidneys: a cautionary story. Br J Radiol. 2007 Dec; 80(960):e305-9. Currie RJ, Freeman SJ, McCormick F, McGonigle RJ. PMID: 18065639.
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    167. Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options. Hum Mol Genet. 2008 Feb 01; 17(3):419-30. Senawong T, Phuchareon J, Ohara O, McCormick F, Rauen KA, Tetsu O. PMID: 17981815.
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    353. Regulators and effectors of ras proteins. Annu Rev Cell Biol. 1991; 7:601-32. Bollag G, McCormick F. PMID: 1667084.
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    354. Purification, characterization, and western blot analysis of human GTPase-activating protein from native and recombinant sources. J Biol Chem. 1990 Dec 15; 265(35):21922-8. Halenbeck R, Crosier WJ, Clark R, McCormick F, Koths K. PMID: 2123878.
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    355. Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein. J Clin Endocrinol Metab. 1990 Dec; 71(6):1416-20. Landis CA, Harsh G, Lyons J, Davis RL, McCormick F, Bourne HR. PMID: 2121775.
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    356. The GTPase superfamily: a conserved switch for diverse cell functions. Nature. 1990 Nov 08; 348(6297):125-32. Bourne HR, Sanders DA, McCormick F. PMID: 2122258.
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    357. Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. Mol Cell Biol. 1990 Nov; 10(11):5977-82. Munemitsu S, Innis MA, Clark R, McCormick F, Ullrich A, Polakis P. PMID: 2122236; PMCID: PMC361395.
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    358. Oncogenes in multiple myeloma: point mutation of N-ras. Oncogene. 1990 Nov; 5(11):1659-63. Paquette RL, Berenson J, Lichtenstein A, McCormick F, Koeffler HP. PMID: 2267133.
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    359. The world according to GAP. Oncogene. 1990 Sep; 5(9):1281-3. McCormick F. PMID: 1699195.
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    360. Suppression of c-ras transformation by GTPase-activating protein. Nature. 1990 Aug 23; 346(6286):754-6. Zhang K, DeClue JE, Vass WC, Papageorge AG, McCormick F, Lowy DR. PMID: 2201922.
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    361. Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product. Science. 1990 Jul 13; 249(4965):169-71. Frech M, John J, Pizon V, Chardin P, Tavitian A, Clark R, McCormick F, Wittinghofer A. PMID: 2164710.
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    362. ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels. Cell. 1990 Jun 01; 61(5):769-76. Yatani A, Okabe K, Polakis P, Halenbeck R, McCormick F, Brown AM. PMID: 2188736.
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    363. Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins. Mol Cell Biol. 1990 Jun; 10(6):2901-8. Quilliam LA, Der CJ, Clark R, O'Rourke EC, Zhang K, McCormick F, Bokoch GM. PMID: 2160589; PMCID: PMC360652.
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    364. PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell. 1990 Apr 06; 61(1):125-33. Kaplan DR, Morrison DK, Wong G, McCormick F, Williams LT. PMID: 2156626.
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    365. GTP binding and growth control. Curr Opin Cell Biol. 1990 Apr; 2(2):181-4. McCormick F. PMID: 2141992.
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    366. Retrospective analysis of ras gene activation in myeloid leukemic cells. Oncogene. 1990 Apr; 5(4):583-7. Lübbert M, Jonas D, Miller CW, Herrmann F, Mertelsmann R, McCormick F, Koeffler HP. PMID: 2183160.
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    367. N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis. Blood. 1990 Mar 01; 75(5):1163-9. Lübbert M, Mirro J, Miller CW, Kahan J, Isaac G, Kitchingman G, Mertelsmann R, Herrmann F, McCormick F, Koeffler HP. PMID: 2407301.
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    368. RAS mutations in patients following cytotoxic therapy for lymphoma. Oncogene. 1990 Mar; 5(3):411-6. Carter G, Hughes DC, Clark RE, McCormick F, Jacobs A, Whittaker JA, Padua RA. PMID: 2179819.
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    369. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature. 1990 Jan 25; 343(6256):377-81. Ellis C, Moran M, McCormick F, Pawson T. PMID: 1689011.
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    370. GAP as ras effector or negative regulator? Mol Carcinog. 1990; 3(4):185-7. McCormick F. PMID: 2206281.
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    371. Genetic analysis of mammalian GAP expressed in yeast. Cell. 1989 Nov 17; 59(4):681-6. Ballester R, Michaeli T, Ferguson K, Xu HP, McCormick F, Wigler M. PMID: 2684416.
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    372. Production of and responsiveness to transforming growth factor-beta in normal and oncogene-transformed human mammary epithelial cells. Cancer Res. 1989 Nov 15; 49(22):6269-74. Valverius EM, Walker-Jones D, Bates SE, Stampfer MR, Clark R, McCormick F, Dickson RB, Lippman ME. PMID: 2553252.
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    373. Gasp: not just another oncogene. Nature. 1989 Aug 31; 340(6236):678-9. McCormick F. PMID: 2505083.
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    374. Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells. Cancer Res. 1989 Aug 01; 49(15):4258-63. Sommers CL, Walker-Jones D, Heckford SE, Worland P, Valverius E, Clark R, McCormick F, Stampfer M, Abularach S, Gelmann EP. PMID: 2472876.
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    375. Human bladder and colon carcinomas contain activated ras p21. Specific detection of twelfth codon mutants. Cancer. 1989 Jun 01; 63(11):2177-81. Meyers FJ, Gumerlock PH, Kokoris SP, deVere White RW, McCormick F. PMID: 2655864.
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    376. Identification of resonances from an oncogenic activating locus of human N-RAS-encoded p21 protein using isotope-edited NMR. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):817-20. Burk SC, Papastavros MZ, McCormick F, Redfield AG. PMID: 2644645; PMCID: PMC286568.
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    377. ras GTPase activating protein: signal transmitter and signal terminator. Cell. 1989 Jan 13; 56(1):5-8. McCormick F. PMID: 2535967.
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    378. Analysis of RAS oncogene mutations in human lymphoid malignancies. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9268-72. Neri A, Knowles DM, Greco A, McCormick F, Dalla-Favera R. PMID: 3057505; PMCID: PMC282720.
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    379. Transformation of human mammary epithelial cells by oncogenic retroviruses. Cancer Res. 1988 Aug 15; 48(16):4689-94. Clark R, Stampfer MR, Milley R, O'Rourke E, Walen KH, Kriegler M, Kopplin J, McCormick F. PMID: 3293776.
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    380. RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation. Leukemia. 1988 Aug; 2(8):503-10. Padua RA, Carter G, Hughes D, Gow J, Farr C, Oscier D, McCormick F, Jacobs A. PMID: 3166076.
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    381. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science. 1988 Apr 22; 240(4851):518-21. Adari H, Lowy DR, Willumsen BM, Der CJ, McCormick F. PMID: 2833817.
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    382. Functional properties of proteins coded by three human alpha-interferon genes and a pseudogene. Cancer Res. 1988 Apr 01; 48(7):1763-70. Creasey AA, Vitt CR, Herst C, O'Rourke E, Doyle L, Innis MA, McCabe PC, McCormick F, Milley R, Lin LS, et al. PMID: 2964896.
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    383. Interaction of ras p21 proteins with GTPase activating protein. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:849-54. McCormick F, Adari H, Trahey M, Halenbeck R, Koths K, Martin GA, Crosier WJ, Watt K, Rubinfeld B, Wong G. PMID: 2855502.
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    384. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science. 1987 Oct 23; 238(4826):542-5. Trahey M, McCormick F. PMID: 2821624.
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    385. Biochemical and biological properties of the human N-ras p21 protein. Mol Cell Biol. 1987 Jan; 7(1):541-4. Trahey M, Milley RJ, Cole GE, Innis M, Paterson H, Marshall CJ, Hall A, McCormick F. PMID: 3550423; PMCID: PMC365100.
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    386. Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells. J Cell Physiol Suppl. 1987; Suppl 5:69-73. Bar-Sagi D, McCormick F, Milley RJ, Feramisco JR. PMID: 3316255.
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    387. Detection of activated Mr 21,000 protein, the product of ras oncogenes, using antibodies with specificity for amino acid 12. Cancer Res. 1986 Dec; 46(12 Pt 1):6029-33. Wong G, Arnheim N, Clark R, McCabe P, Innis M, Aldwin L, Nitecki D, McCormick F. PMID: 3490906.
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    388. Genetic and biochemical analysis of ras p21 structure. Symp Fundam Cancer Res. 1986; 39:137-42. McCormick F, Levenson C, Cole G, Innis M, Clark R. PMID: 3321304.
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    389. Procedures for expression, modification, and analysis of human fibroblast interferon (IFN-beta) genes in heterologous cells. Methods Enzymol. 1986; 119:397-403. Innis MA, McCormick F. PMID: 3531770.
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    390. Antibodies specific for amino acid 12 of the ras oncogene product inhibit GTP binding. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5280-4. Clark R, Wong G, Arnheim N, Nitecki D, McCormick F. PMID: 3927300; PMCID: PMC390551.
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    391. Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein. Nature. 1985 Apr 18-24; 314(6012):639-42. Feramisco JR, Clark R, Wong G, Arnheim N, Milley R, McCormick F. PMID: 2581140.
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    392. Inhibition of protein synthesis stimulates the transcription of human beta-interferon genes in Chinese hamster ovary cells. Proc Natl Acad Sci U S A. 1984 Jul; 81(13):3964-8. Ringold GM, Dieckmann B, Vannice JL, Trahey M, McCormick F. PMID: 6330726; PMCID: PMC345348.
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    393. Inducible expression of amplified human beta interferon genes in CHO cells. Mol Cell Biol. 1984 Jan; 4(1):166-72. McCormick F, Trahey M, Innis M, Dieckmann B, Ringold G. PMID: 6700582; PMCID: PMC368671.
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    394. SV40 T antigen binds specifically to a cellular 53 K protein in vitro. Nature. 1981 Jul 02; 292(5818):63-5. McCormick F, Clark R, Harlow E, Tjian R. PMID: 6268984.
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    395. Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells. J Virol. 1980 Apr; 34(1):213-24. McCormick F, Harlow E. PMID: 6246255; PMCID: PMC288687.
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    396. T antigens of SV40-transformed cells. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:171-8. McCormick F, Chaudry F, Harvey R, Smith R, Rigby PW, Paucha E, Smith AE. PMID: 6253131.
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