Frank McCormick, PhD, FRS

Title(s)Professor, HDF Comprehensive Cancer Ctr
SchoolSchool of Medicine
Address1450 Third Street, #371
San Francisco CA 94158
Phone415-502-1707
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    Collapse Overview
    Frank McCormick, PhD, FRS, is a Professor in the UCSF Helen Diller Family Comprehensive Cancer Center. Prior to joining the UCSF faculty, Dr. McCormick pursued cancer-related work with several Bay Area biotechnology firms and held positions with Cetus Corporation (Director of Molecular Biology, 1981-1990; Vice President of Research, 1990-1991) and Chiron Corporation, where he was Vice President of Research from 1991 to 1992. In 1992 he founded Onyx Pharmaceuticals, a company dedicated to developing new cancer therapies, and served as its Chief Scientific Officer until 1996. At Onyx Pharmaceuticals, he initiated and led drug discovery efforts that led to the approval of Sorafenib in 2005 for treatment of renal cell cancer, and for liver cancer in 2007, and the approval of ONYX-015 in 2006 in China for treatment of nasopharyngeal cancer. Sorafenib is being tested in multiple indications worldwide. In addition, Dr. McCormick’s group led to the identification of a CDK4 kinase inhibitor. Dr. McCormick's current research interests center on the fundamental differences between normal and cancer cells that can allow the discovery of novel therapeutic strategies.

    Dr. McCormick holds the David A. Wood Chair of Tumor Biology and Cancer Research at UCSF. Dr. McCormick is the author of over 285 scientific publications and holds 20 issued patents. He also served as President, 2012-2013 for the American Association for Cancer Research (AACR). More recently, he has taken a leadership role at the Frederick National Lab for Cancer Research, overseeing an NCI supported national effort to develop therapies against Ras-driven cancers. These cancers include most pancreatic cancers, and many colorectal and lung cancers, and are amongst the most difficult cancers to treat.

    Collapse Research 
    Collapse Research Activities and Funding
    Biodesy Delta System for San Francisco Bay Area Region
    NIH S10OD023482Mar 15, 2017 - Mar 14, 2018
    Role: Principal Investigator
    New Ways of Targeting K-Ras
    NIH R35CA197709Apr 1, 2016 - Mar 31, 2023
    Role: Principal Investigator
    Bay Area Cancer Target Discovery and Development Network
    NIH U01CA168370May 1, 2012 - Apr 30, 2017
    Role: Co-Principal Investigator
    Cancer Center Support Grant
    NIH P30CA082103Aug 5, 1999 - May 31, 2023
    Role: Co-Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations. Sci Rep. 2024 10 26; 14(1):25452. Yi M, Soppet D, McCormick F, Nissley DV. PMID: 39455841; PMCID: PMC11511894.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity. bioRxiv. 2024 Oct 25. Kwon JJ, Dilly J, Liu S, Kim E, Bian Y, Dharmaiah S, Tran TH, Kapner KS, Ly SH, Yang X, Rabara D, Waybright TJ, Giacomelli AO, Hong AL, Misek S, Wang B, Ravi A, Doench JG, Beroukhim R, Lemke CT, Haigis KM, Esposito D, Root DE, Nissley DV, Stephen AG, McCormick F, Simanshu DK, Hahn WC, Aguirre AJ. PMID: 39484452; PMCID: PMC11526993.
      View in: PubMed   Mentions:
    3. Inhibition and degradation of NRAS with a pan-NRAS monobody. Oncogene. 2024 Oct 08. Whaby M, Ketavarapu G, Koide A, Mazzei M, Mintoo M, Glasser E, Patel U, Nasarre C, Sale MJ, McCormick F, Koide S, O'Bryan JP. PMID: 39379700.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Anal Chem. 2024 04 02; 96(13):5223-5231. D'Ippolito RA, Rabara D, Blanco MA, Alberico E, Drew MR, Ramakrishnan N, Sontan D, Widmeyer SRT, Scheidemantle GM, Messing S, Turner D, Arkin M, Maciag AE, Stephen AG, Esposito D, McCormick F, Nissley DV, DeHart CJ. PMID: 38498381; PMCID: PMC10993199.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    5. Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Commun Biol. 2024 Mar 02; 7(1):260. Finci LI, Chakrabarti M, Gulten G, Finney J, Grose C, Fox T, Yang R, Nissley DV, McCormick F, Esposito D, Balius TE, Simanshu DK. PMID: 38431713; PMCID: PMC10908828.
      View in: PubMed   Mentions: 1  Translation:HumansCells
    6. Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties. Sci Adv. 2024 Feb 16; 10(7):eadj4137. Whitley MJ, Tran TH, Rigby M, Yi M, Dharmaiah S, Waybright TJ, Ramakrishnan N, Perkins S, Taylor T, Messing S, Esposito D, Nissley DV, McCormick F, Stephen AG, Turbyville T, Cornilescu G, Simanshu DK. PMID: 38354232.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    7. Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR. J Biol Chem. 2024 Feb; 300(2):105650. Sharma AK, Pei J, Yang Y, Dyba M, Smith B, Rabara D, Larsen EK, Lightstone FC, Esposito D, Stephen AG, Wang B, Beltran PJ, Wallace E, Nissley DV, McCormick F, Maciag AE. PMID: 38237681; PMCID: PMC10877953.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    8. Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance. Nat Commun. 2024 Jan 12; 15(1):477. Vasudevan HN, Payne E, Delley CL, John Liu S, Mirchia K, Sale MJ, Lastella S, Nunez MS, Lucas CG, Eaton CD, Casey-Clyde T, Magill ST, Chen WC, Braunstein SE, Perry A, Jacques L, Reddy AT, Pekmezci M, Abate AR, McCormick F, Raleigh DR. PMID: 38216572; PMCID: PMC10786885.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Determining KRAS4B-Targeting Compound Specificity by Top-Down Mass Spectrometry. Methods Mol Biol. 2024; 2823:291-310. D'Ippolito RA, Scheidemantle GM, Rabara D, Abreu Blanco M, Ramakrishnan N, Widmeyer SRT, Messing S, Turner D, Maciag AE, Stephen AG, Esposito D, McCormick F, Nissley DV, DeHart CJ. PMID: 39052227.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Progress in Targeting KRAS Directly. Methods Mol Biol. 2024; 2797:1-12. Nissley DV, Stephen AG, Yi M, McCormick F. PMID: 38570448.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    11. Long-term ecological research in freshwaters enabled by regional biodiversity collections, stable isotope analysis, and environmental informatics. Bioscience. 2023 Jul 29; 73(7):479-493. Turner TF, Bart HL, McCormick F, Besser AC, Bowes RE, Capps KA, DeArmon ES, Dillman CB, Driscoll KP, Dugger A, Hamilton GL, Harris PM, Hendrickson DA, Hoffman J, Knouft JH, Lepak RF, López-Fernández H, Montaña CG, Newsome SD, Pease AA, Smith WL, Taylor CA, Welicky RL. PMID: 37841229; PMCID: PMC10569117.
      View in: PubMed   Mentions:    Fields:    
    12. RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy. Sci Adv. 2023 07 14; 9(28):eadf4766. Cuevas-Navarro A, Wagner M, Van R, Swain M, Mo S, Columbus J, Allison MR, Cheng A, Messing S, Turbyville TJ, Simanshu DK, Sale MJ, McCormick F, Stephen AG, Castel P. PMID: 37450595; PMCID: PMC10348673.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D. Commun Biol. 2023 06 02; 6(1):594. Chao FA, Chan AH, Dharmaiah S, Schwieters CD, Tran TH, Taylor T, Ramakrishnan N, Esposito D, Nissley DV, McCormick F, Simanshu DK, Cornilescu G. PMID: 37268708; PMCID: PMC10238545.
      View in: PubMed   Mentions: 3  Translation:Cells
    14. RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights. J Invest Dermatol. 2023 08; 143(8):1358-1368. Rhodes SD, McCormick F, Cagan RL, Bakker A, Staedtke V, Ly I, Steensma MR, Lee SY, Romo CG, Blakeley JO, Sarin KY. PMID: 37245145; PMCID: PMC10409534.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling. J Biol Chem. 2023 06; 299(6):104789. Lopez J, Bonsor DA, Sale MJ, Urisman A, Mehalko JL, Cabanski-Dunning M, Castel P, Simanshu DK, McCormick F. PMID: 37149146; PMCID: PMC10248553.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Proc Natl Acad Sci U S A. 2023 Jan 31; 120(5):e2208960120. Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A, Drew M, Darling J, Wall V, Grisshammer R, Cheng A, Allison MR, Sale MJ, Nissley DV, Esposito D, Ognjenovic J, McCormick F. PMID: 36689660; PMCID: PMC9945959.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. Cancer Discov. 2022 10 05; 12(10):2434-2453. Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, Durham BH, Pavletich TS, Fiala E, Walsh MF, Inoue D, Monette S, Taylor J, Rosen N, McCormick F, Lindsley RC, Castel P, Abdel-Wahab O. PMID: 35904492; PMCID: PMC9533010.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    18. Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Nat Struct Mol Biol. 2022 10; 29(10):966-977. Bonsor DA, Alexander P, Snead K, Hartig N, Drew M, Messing S, Finci LI, Nissley DV, McCormick F, Esposito D, Rodriguez-Viciana P, Stephen AG, Simanshu DK. PMID: 36175670; PMCID: PMC10365013.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    19. Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells. Metabolites. 2022 Sep 02; 12(9). Kim SH, Song JH, Kim MJ, Song MG, Ku AA, Bandyopadhyay S, McCormick F, Kim SE. PMID: 36144235; PMCID: PMC9502772.
      View in: PubMed   Mentions:
    20. Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature. 2022 09; 609(7926):408-415. Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ. PMID: 35831509; PMCID: PMC9694338.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    21. ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. Mol Cell. 2022 07 07; 82(13):2443-2457.e7. Su W, Mukherjee R, Yaeger R, Son J, Xu J, Na N, Merna Timaul N, Hechtman J, Paroder V, Lin M, Mattar M, Qiu J, Chang Q, Zhao H, Zhang J, Little M, Adachi Y, Han SW, Taylor BS, Ebi H, Abdel-Wahab O, de Stanchina E, Rudin CM, Jänne PA, McCormick F, Yao Z, Rosen N. PMID: 35613620; PMCID: PMC9271631.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    22. Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs. Elife. 2022 04 25; 11. Cuevas-Navarro A, Rodriguez-Muñoz L, Grego-Bessa J, Cheng A, Rauen KA, Urisman A, McCormick F, Jimenez G, Castel P. PMID: 35467524; PMCID: PMC9068208.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. Targeting CD70 in cutaneous T-cell lymphoma using an antibody-drug conjugate in patient-derived xenograft models. Blood Adv. 2022 04 12; 6(7):2290-2302. Wu CH, Wang L, Yang CY, Wen KW, Hinds B, Gill R, McCormick F, Moasser M, Pincus L, Ai WZ. PMID: 34872108; PMCID: PMC9006301.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    24. RAS at 40: Update from the RAS Initiative. Cancer Discov. 2022 04 01; 12(4):895-898. Nissley DV, McCormick F. PMID: 35046096.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    25. More to the RAS Story: KRASG12C Inhibition, Resistance Mechanisms, and Moving Beyond KRASG12C. Am Soc Clin Oncol Educ Book. 2022 Apr; 42:1-13. Lietman CD, Johnson ML, McCormick F, Lindsay CR. PMID: 35561303.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    26. Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics. J Am Chem Soc. 2022 03 09; 144(9):4196-4205. Chao FA, Dharmaiah S, Taylor T, Messing S, Gillette W, Esposito D, Nissley DV, McCormick F, Byrd RA, Simanshu DK, Cornilescu G. PMID: 35213144; PMCID: PMC10430694.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    27. Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors. Proc Natl Acad Sci U S A. 2022 02 01; 119(5). Lai LP, Fer N, Burgan W, Wall VE, Xu B, Soppet D, Esposito D, Nissley DV, McCormick F. PMID: 35091470; PMCID: PMC8812530.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    28. Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins. Proc Natl Acad Sci U S A. 2022 01 04; 119(1). Ingólfsson HI, Neale C, Carpenter TS, Shrestha R, López CA, Tran TH, Oppelstrup T, Bhatia H, Stanton LG, Zhang X, Sundram S, Di Natale F, Agarwal A, Dharuman G, Kokkila Schumacher SIL, Turbyville T, Gulten G, Van QN, Goswami D, Jean-Francois F, Agamasu C, Hettige JJ, Travers T, Sarkar S, Surh MP, Yang Y, Moody A, Liu S, Van Essen BC, Voter AF, Ramanathan A, Hengartner NW, Simanshu DK, Stephen AG, Bremer PT, Gnanakaran S, Glosli JN, Lightstone FC, McCormick F, Nissley DV, Streitz FH. PMID: 34983849; PMCID: PMC8740753.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    29. Cost Structures of US Organ Procurement Organizations. Transplantation. 2021 12 01; 105(12):2612-2619. Held PJ, Bragg-Gresham JL, Peters TG, McCormick F, Chertow G, Vaughan WP, Roberts JP. PMID: 33988344.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. NMR 1H, 13C, 15N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation. Biomol NMR Assign. 2022 04; 16(1):1-8. Sharma AK, Dyba M, Tonelli M, Smith B, Gillette WK, Esposito D, Nissley DV, McCormick F, Maciag AE. PMID: 34686998; PMCID: PMC9068649.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    31. A brief history of RAS and the RAS Initiative. Adv Cancer Res. 2022; 153:1-27. McCormick F. PMID: 35101227.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    32. RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity. Proc Natl Acad Sci U S A. 2021 08 17; 118(33). Castel P, Dharmaiah S, Sale MJ, Messing S, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D, Simanshu DK, McCormick F. PMID: 34380736; PMCID: PMC8379911.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    33. UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). Wolfe AL, Zhou Q, Toska E, Galeas J, Ku AA, Koche RP, Bandyopadhyay S, Scaltriti M, Lebrilla CB, McCormick F, Kim SE. PMID: 34330832; PMCID: PMC8346792.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    34. Inhibition of MET Signaling with Ficlatuzumab in Combination with Chemotherapy in Refractory AML: Clinical Outcomes and High-Dimensional Analysis. Blood Cancer Discov. 2021 09; 2(5):434-449. Wang VE, Blaser BW, Patel RK, Behbehani GK, Rao AA, Durbin-Johnson B, Jiang T, Logan AC, Settles M, Mannis GN, Olin R, Damon LE, Martin TG, Sayre PH, Gaensler KM, McMahon E, Flanders M, Weinberg V, Ye CJ, Carbone DP, Munster PN, Fragiadakis GK, McCormick F, Andreadis C. PMID: 34514432; PMCID: PMC8425277.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness. Front Cell Dev Biol. 2021; 9:665673. Okutachi S, Manoharan GB, Kiriazis A, Laurini C, Catillon M, McCormick F, Yli-Kauhaluoma J, Abankwa D. PMID: 34307350; PMCID: PMC8296985.
      View in: PubMed   Mentions: 8  
    36. The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. Curr Biol. 2021 09 13; 31(17):3915-3924.e9. Cuevas-Navarro A, Van R, Cheng A, Urisman A, Castel P, McCormick F. PMID: 34237269; PMCID: PMC8440430.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    37. Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Cell Rep Methods. 2021 07 26; 1(3). Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. PMID: 34671754; PMCID: PMC8525888.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    38. Estimated impact of novel coronavirus-19 and transplant center inactivity on end-stage renal disease-related patient mortality in the United States. Clin Transplant. 2021 08; 35(8):e14292. Peters TG, Bragg-Gresham JL, Klopstock AC, Roberts JP, Chertow G, McCormick F, Held PJ. PMID: 33749935; PMCID: PMC8250232.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    39. RAS-targeted therapies. Nat Rev Drug Discov. 2021 May 14. Moore AR, Rosenberg SC, McCormick F, Malek S. PMID: 33990767.
      View in: PubMed   Mentions: 6     Fields:    
    40. Sensitivity of Oncogenic KRAS-Expressing Cells to CDK9 Inhibition. SLAS Discov. 2021 08; 26(7):922-932. Lai LP, Brel V, Sharma K, Frappier J, Le-Henanf N, Vivet B, Muzet N, Schell E, Morales R, Rooney E, Basse N, Yi M, Lacroix F, Holderfield M, Englaro W, Marcireau C, Debussche L, Nissley DV, McCormick F. PMID: 33896272; PMCID: PMC8791284.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    41. Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nat Genet. 2021 05; 53(5):707-718. Inoue D, Polaski JT, Taylor J, Castel P, Chen S, Kobayashi S, Hogg SJ, Hayashi Y, Pineda JMB, El Marabti E, Erickson C, Knorr K, Fukumoto M, Yamazaki H, Tanaka A, Fukui C, Lu SX, Durham BH, Liu B, Wang E, Mehta S, Zakheim D, Garippa R, Penson A, Chew GL, McCormick F, Bradley RK, Abdel-Wahab O. PMID: 33846634; PMCID: PMC8177065.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    42. The Metabolic Landscape of RAS-Driven Cancers from biology to therapy. Nat Cancer. 2021 03; 2(3):271-283. Mukhopadhyay S, Vander Heiden MG, McCormick F. PMID: 33870211; PMCID: PMC8045781.
      View in: PubMed   Mentions: 123     Fields:    Translation:Humans
    43. Correction: DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs. J Biol Chem. 2021 Jan-Jun; 296:100380. Castel P, Holtz-Morris A, Kwon Y, Suter BP, McCormick F. PMID: 33837738; PMCID: PMC7949137.
      View in: PubMed   Mentions:    Fields:    
    44. KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun. 2021 02 19; 12(1):1176. Tran TH, Chan AH, Young LC, Bindu L, Neale C, Messing S, Dharmaiah S, Taylor T, Denson JP, Esposito D, Nissley DV, Stephen AG, McCormick F, Simanshu DK. PMID: 33608534; PMCID: PMC7895934.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansCells
    45. Author Correction: RAS-targeted therapies: is the undruggable drugged? Nat Rev Drug Discov. 2020 Dec; 19(12):902. Moore AR, Rosenberg SC, McCormick F, Malek S. PMID: 33082552.
      View in: PubMed   Mentions: 12     Fields:    
    46. Reducing the Shortage of Transplant Kidneys: A Lost Opportunity for the US Health Resources and Services Administration (HRSA). Am J Kidney Dis. 2021 06; 77(6):963-966. McCormick F, Held PJ, Chertow GM, Peters TG, Roberts JP. PMID: 33271212.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    47. DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs. J Biol Chem. 2021 Jan-Jun; 296:100023. Castel P, Holtz-Morris A, Kwon Y, Suter BP, McCormick F. PMID: 33410398; PMCID: PMC7949039.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    48. SPRED proteins and their roles in signal transduction, development, and malignancy. Genes Dev. 2020 11 01; 34(21-22):1410-1421. Lorenzo C, McCormick F. PMID: 33872193; PMCID: PMC7608746.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    49. Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway. Mol Syst Biol. 2020 10; 16(10):e9518. Gillies TE, Pargett M, Silva JM, Teragawa CK, McCormick F, Albeck JG. PMID: 33073539; PMCID: PMC7569415.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    50. Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24258-24268. Van QN, López CA, Tonelli M, Taylor T, Niu B, Stanley CB, Bhowmik D, Tran TH, Frank PH, Messing S, Alexander P, Scott D, Ye X, Drew M, Chertov O, Lösche M, Ramanathan A, Gross ML, Hengartner NW, Westler WM, Markley JL, Simanshu DK, Nissley DV, Gillette WK, Esposito D, McCormick F, Gnanakaran S, Heinrich F, Stephen AG. PMID: 32913056; PMCID: PMC7533834.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    51. The molecular functions of RIT1 and its contribution to human disease. Biochem J. 2020 08 14; 477(15):2755-2770. Van R, Cuevas-Navarro A, Castel P, McCormick F. PMID: 32766847; PMCID: PMC7787054.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    52. Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Rep. 2020 07 21; 32(3):107909. Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK. PMID: 32697994; PMCID: PMC7437355.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
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    114. Resistance to EGFR-targeted therapy by Ets-1 inactivation. Cell Cycle. 2015; 14(20):3211-2. Tetsu O, Eisele DW, McCormick F. PMID: 26313421; PMCID: PMC4825599.
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    115. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discov. 2015 02; 5(2):154-67. Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakhshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S. PMID: 25501949; PMCID: PMC4407699.
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    116. Fatty Acid binding protein 7 is a molecular marker in adenoid cystic carcinoma of the salivary glands: implications for clinical significance. Transl Oncol. 2014 Dec; 7(6):780-7. Phuchareon J, Overdevest JB, McCormick F, Eisele DW, van Zante A, Tetsu O. PMID: 25500088; PMCID: PMC4311037.
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    117. Social interactomes for enabling research communities. Cancer Discov. 2014 Nov; 4(11):1265-8. Guinney J, Dienstmann R, Ferté C, Friend S, McCormick F. PMID: 25367949.
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    118. c-Kit Expression is Rate-Limiting for Stem Cell Factor-Mediated Disease Progression in Adenoid Cystic Carcinoma of the Salivary Glands. Transl Oncol. 2014 Oct; 7(5):537-45. Phuchareon J, van Zante A, Overdevest JB, McCormick F, Eisele DW, Tetsu O. PMID: 25389449; PMCID: PMC4225653.
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    120. Development of siRNA payloads to target KRAS-mutant cancer. Cancer Discov. 2014 Oct; 4(10):1182-1197. Yuan TL, Fellmann C, Lee CS, Ritchie CD, Thapar V, Lee LC, Hsu DJ, Grace D, Carver JO, Zuber J, Luo J, McCormick F, Lowe SW. PMID: 25100204; PMCID: PMC4184972.
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    121. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. Nat Rev Cancer. 2014 Jul; 14(7):455-67. Holderfield M, Deuker MM, McCormick F, McMahon M. PMID: 24957944; PMCID: PMC4250230.
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    122. Unicompartmental knee arthroplasty versus high tibial osteotomy: United States practice patterns for the surgical treatment of unicompartmental arthritis. J Arthroplasty. 2014 Aug; 29(8):1586-9. Nwachukwu BU, McCormick FM, Schairer WW, Frank RM, Provencher MT, Roche MW. PMID: 24814891.
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    123. Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell Metab. 2014 Apr 01; 19(4):694-701. Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR. PMID: 24703700; PMCID: PMC4294542.
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    124. Dragging ras back in the ring. Cancer Cell. 2014 Mar 17; 25(3):272-81. Stephen AG, Esposito D, Bagni RK, McCormick F. PMID: 24651010.
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    125. Current status of evidence-based sports medicine. Arthroscopy. 2014 Mar; 30(3):362-71. Harris JD, Cvetanovich G, Erickson BJ, Abrams GD, Chahal J, Gupta AK, McCormick FM, Bach BR. PMID: 24581261.
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    126. Vemurafenib cooperates with HPV to promote initiation of cutaneous tumors. Cancer Res. 2014 Apr 15; 74(8):2238-45. Holderfield M, Lorenzana E, Weisburd B, Lomovasky L, Boussemart L, Lacroix L, Tomasic G, Favre M, Vagner S, Robert C, Ghoddusi M, Daniel D, Pryer N, McCormick F, Stuart D. PMID: 24523442.
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    127. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014; 9(2):e87220. Kashiyama T, Oda K, Ikeda Y, Shiose Y, Hirota Y, Inaba K, Makii C, Kurikawa R, Miyasaka A, Koso T, Fukuda T, Tanikawa M, Shoji K, Sone K, Arimoto T, Wada-Hiraike O, Kawana K, Nakagawa S, Matsuda K, McCormick F, Aburatani H, Yano T, Osuga Y, Fujii T. PMID: 24504419; PMCID: PMC3913610.
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    128. Functional Performance Testing After Anterior Cruciate Ligament Reconstruction: A Systematic Review. Orthop J Sports Med. 2014 Jan; 2(1):2325967113518305. Abrams GD, Harris JD, Gupta AK, McCormick FM, Bush-Joseph CA, Verma NN, Cole BJ, Bach BR. PMID: 26535266; PMCID: PMC4555525.
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    129. CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies. Am J Med Genet A. 2014 Mar; 164A(3):563-78. Widemann BC, Acosta MT, Ammoun S, Belzberg AJ, Bernards A, Blakeley J, Bretscher A, Cichowski K, Clapp DW, Dombi E, Evans GD, Ferner R, Fernandez-Valle C, Fisher MJ, Giovannini M, Gutmann DH, Hanemann CO, Hennigan R, Huson S, Ingram D, Kissil J, Korf BR, Legius E, Packer RJ, McClatchey AI, McCormick F, North K, Pehrsson M, Plotkin SR, Ramesh V, Ratner N, Schirmer S, Sherman L, Schorry E, Stevenson D, Stewart DR, Ullrich N, Bakker AC, Morrison H. PMID: 24443315; PMCID: PMC4150212.
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    130. Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation. Cancer Discov. 2014 Feb; 4(2):186-99. Salt MB, Bandyopadhyay S, McCormick F. PMID: 24302555.
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    131. High mobility group box 1 promotes tumor cell migration through epigenetic silencing of semaphorin 3A. Oncogene. 2014 Oct 30; 33(44):5151-62. Nehil M, Paquette J, Tokuyasu T, McCormick F. PMID: 24213571.
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    132. Killing tumors by keeping ras and PI3' kinase apart. Cancer Cell. 2013 Nov 11; 24(5):562-3. Yuan TL, McCormick F. PMID: 24229705.
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    133. Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18519-24. Nan X, Collisson EA, Lewis S, Huang J, Tamgüney TM, Liphardt JT, McCormick F, Gray JW, Chu S. PMID: 24158481; PMCID: PMC3831949.
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    134. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell. 2013 Oct 14; 24(4):450-65. Timmerman LA, Holton T, Yuneva M, Louie RJ, Padró M, Daemen A, Hu M, Chan DA, Ethier SP, van 't Veer LJ, Polyak K, McCormick F, Gray JW. PMID: 24094812; PMCID: PMC3931310.
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    135. MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13845-50. Lyons J, Bastian BC, McCormick F. PMID: 23908401; PMCID: PMC3752210.
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    136. RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation. Cancer Cell. 2013 May 13; 23(5):594-602. Holderfield M, Merritt H, Chan J, Wallroth M, Tandeske L, Zhai H, Tellew J, Hardy S, Hekmat-Nejad M, Stuart DD, McCormick F, Nagel TE. PMID: 23680146.
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    137. An assessment of the quality of rotator cuff randomized controlled trials: utilizing the Jadad score and CONSORT criteria. J Shoulder Elbow Surg. 2013 Sep; 22(9):1180-5. McCormick F, Cvetanovich GL, Kim JM, Harris JD, Gupta AK, Abrams GD, Romeo AA, Provencher MT. PMID: 23510746.
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    138. Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov. 2013 Jan; 3(1):112-23. Young A, Lou D, McCormick F. PMID: 23103856.
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    139. A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1. Genes Dev. 2012 Jul 01; 26(13):1421-6. Stowe IB, Mercado EL, Stowe TR, Bell EL, Oses-Prieto JA, Hernández H, Burlingame AL, McCormick F. PMID: 22751498; PMCID: PMC3403010.
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    140. Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas. PLoS One. 2012; 7(5):e37431. Shoji K, Oda K, Kashiyama T, Ikeda Y, Nakagawa S, Sone K, Miyamoto Y, Hiraike H, Tanikawa M, Miyasaka A, Koso T, Matsumoto Y, Wada-Hiraike O, Kawana K, Kuramoto H, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y. PMID: 22662154; PMCID: PMC3360787.
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    141. Cancer therapy based on oncogene addiction. J Surg Oncol. 2011 May 01; 103(6):464-7. McCormick F. PMID: 21480237.
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    142. Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies. Am J Med Genet C Semin Med Genet. 2011 May 15; 157C(2):136-46. Rauen KA, Banerjee A, Bishop WR, Lauchle JO, McCormick F, McMahon M, Melese T, Munster PN, Nadaf S, Packer RJ, Sebolt-Leopold J, Viskochil DH. PMID: 21495172; PMCID: PMC4145816.
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    143. Promoting growth for preterm infants following hospital discharge. Arch Dis Child Fetal Neonatal Ed. 2012 Jul; 97(4):F295-8. Morgan JA, Young L, McCormick FM, McGuire W. PMID: 21406452.
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    144. Therapeutic strategies for targeting ras proteins. Genes Cancer. 2011 Mar; 2(3):359-72. Gysin S, Salt M, Young A, McCormick F. PMID: 21779505; PMCID: PMC3128641.
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    146. Mad2 inhibits the mitotic kinesin MKlp2. J Cell Biol. 2010 Dec 13; 191(6):1069-77. Lee SH, McCormick F, Saya H. PMID: 21149564; PMCID: PMC3002031.
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    147. Comparison of oncolytic adenoviruses for selective eradication of oral cancer and pre-cancerous lesions. Gene Ther. 2010 Dec; 17(12):1517-24. van Zeeburg HJ, Huizenga A, Brink A, van den Doel PB, Zhu ZB, McCormick F, Brakenhoff RH, van Beusechem VW. PMID: 20686507.
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    148. Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells. Virol J. 2010 Jul 08; 7:148. Lyle C, McCormick F. PMID: 20615244; PMCID: PMC2909962.
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    149. Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator. Cancer Cell. 2010 Jun 15; 17(6):574-83. Ishida S, McCormick F, Smith-McCune K, Hanahan D. PMID: 20541702; PMCID: PMC2902369.
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    150. The molecular pathology of cancer. Nat Rev Clin Oncol. 2010 May; 7(5):251-65. Harris TJ, McCormick F. PMID: 20351699.
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    151. The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Mol Cell Biol. 2010 May; 30(9):2264-79. Phan VT, Ding VW, Li F, Chalkley RJ, Burlingame A, McCormick F. PMID: 20160012; PMCID: PMC2863595.
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    152. What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers. Am J Med Genet A. 2010 Feb; 152A(2):269-83. Kissil JL, Blakeley JO, Ferner RE, Huson SM, Kalamarides M, Mautner VF, McCormick F, Morrison H, Packer R, Ramesh V, Ratner N, Rauen KA, Stevenson DA, Hunter-Schaedle K, North K. PMID: 20082461; PMCID: PMC2818482.
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    153. How blocking Raf activates the MAPK pathway. Pigment Cell Melanoma Res. 2010 Apr; 23(2):187-9. McCormick F. PMID: 20128874.
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    154. Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway. Oncogene. 2010 Apr 01; 29(13):1897-908. Murayama-Hosokawa S, Oda K, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K, Ikeda Y, Uehara Y, Fukayama M, McCormick F, Yano T, Taketani Y, Aburatani H. PMID: 20062086.
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    155. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A. 2010 Jan; 152A(1):4-24. Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. PMID: 20014119; PMCID: PMC4051786.
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    156. EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal. 2009 Jan 27; 2(55):ra4. Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. PMID: 19176518; PMCID: PMC2793677.
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    157. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565-72. Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. PMID: 19147570; PMCID: PMC2737189.
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    158. Ras signaling and therapies. Adv Cancer Res. 2009; 102:1-17. Young A, Lyons J, Miller AL, Phan VT, Alarcón IR, McCormick F. PMID: 19595305.
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    159. Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint. Genes Dev. 2008 Nov 01; 22(21):2926-31. Lee SH, Sterling H, Burlingame A, McCormick F. PMID: 18981471; PMCID: PMC2577792.
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    160. PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Res. 2008 Oct 01; 68(19):8127-36. Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, McCormick F. PMID: 18829572.
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    162. Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR. Leukemia. 2009 Feb; 23(2):396-9. Oehler VG, Qin J, Ramakrishnan R, Facer G, Ananthnarayan S, Cummings C, Deininger M, Shah N, McCormick F, Willis S, Daridon A, Unger M, Radich JP. PMID: 18615105; PMCID: PMC3655797.
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    163. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. Oncogene. 2008 Sep 11; 27(40):5303-14. Kitagawa M, Aonuma M, Lee SH, Fukutake S, McCormick F. PMID: 18521084.
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    164. An analysis of the rotator interval in patients with anterior, posterior, and multidirectional shoulder instability. Arthroscopy. 2008 Aug; 24(8):921-9. Provencher MT, Dewing CB, Bell SJ, McCormick F, Solomon DJ, Rooney TB, Stanley M. PMID: 18657741.
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    165. Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007. Am J Med Genet A. 2008 May 01; 146A(9):1205-17. Rauen KA, Hefner E, Carrillo K, Taylor J, Messier L, Aoki Y, Gripp KW, Matsubara Y, Proud VK, Hammond P, Allanson JE, Delrue MA, Axelrad ME, Lin AE, Doyle DA, Kerr B, Carey JC, McCormick F, Silva AJ, Kieran MW, Hinek A, Nguyen TT, Schoyer L. PMID: 18412122.
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    166. Combinatorial patterns of somatic gene mutations in cancer. FASEB J. 2008 Aug; 22(8):2605-22. Yeang CH, McCormick F, Levine A. PMID: 18434431.
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    167. Skp2 suppresses p53-dependent apoptosis by inhibiting p300. Mol Cell. 2008 Feb 01; 29(2):217-31. Kitagawa M, Lee SH, McCormick F. PMID: 18243116.
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    168. An analysis of capsular area in patients with anterior, posterior, and multidirectional shoulder instability. Am J Sports Med. 2008 Mar; 36(3):515-22. Dewing CB, McCormick F, Bell SJ, Solomon DJ, Stanley M, Rooney TB, Provencher MT. PMID: 18216272.
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    169. Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy. PLoS One. 2007 Dec 05; 2(12):e1279. Estep AL, Palmer C, McCormick F, Rauen KA. PMID: 18060073; PMCID: PMC2093994.
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    170. Polycystic kidneys: a cautionary story. Br J Radiol. 2007 Dec; 80(960):e305-9. Currie RJ, Freeman SJ, McCormick F, McGonigle RJ. PMID: 18065639.
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    171. Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options. Hum Mol Genet. 2008 Feb 01; 17(3):419-30. Senawong T, Phuchareon J, Ohara O, McCormick F, Rauen KA, Tetsu O. PMID: 17981815.
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    172. Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst. 2007 Sep 19; 99(18):1410-4. Jiang H, Gomez-Manzano C, Aoki H, Alonso MM, Kondo S, McCormick F, Xu J, Kondo Y, Bekele BN, Colman H, Lang FF, Fueyo J. PMID: 17848677.
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    173. Success and failure on the ras pathway. Cancer Biol Ther. 2007 Oct; 6(10):1654-9. McCormick F. PMID: 18245956.
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    174. Critical role for arginine methylation in adenovirus-infected cells. J Virol. 2007 Dec; 81(23):13209-17. Iacovides DC, O'Shea CC, Oses-Prieto J, Burlingame A, McCormick F. PMID: 17686851; PMCID: PMC2169124.
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    175. Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways. J Mol Med (Berl). 2007 Nov; 85(11):1281-9. Ding VW, Lin LP, Chiang AL, McCormick F. PMID: 17593335.
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    176. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS One. 2006 Dec 27; 1:e128. Okabe H, Lee SH, Phuchareon J, Albertson DG, McCormick F, Tetsu O. PMID: 17205132; PMCID: PMC1762433.
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    177. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 2006 Dec; 10(6):515-27. Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW. PMID: 17157791; PMCID: PMC2730521.
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    178. p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins. EMBO J. 2006 Sep 06; 25(17):4008-19. Lee SH, McCormick F. PMID: 16932749; PMCID: PMC1560370.
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    179. Oncolytic adenoviruses as antiglioma agents. Expert Rev Anticancer Ther. 2006 May; 6(5):697-708. Jiang H, McCormick F, Lang FF, Gomez-Manzano C, Fueyo J. PMID: 16759161.
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    180. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Mol Cell. 2006 Apr 21; 22(2):217-30. Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F. PMID: 16630891.
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    181. Ras ubiquitination: coupling spatial sorting and signal transmission. Cancer Cell. 2006 Apr; 9(4):243-4. Rodriguez-Viciana P, McCormick F. PMID: 16616329.
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    351. Differential regulation of rasGAP and neurofibromatosis gene product activities. Nature. 1991 Jun 13; 351(6327):576-9. Bollag G, McCormick F. PMID: 1904555.
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    352. GTP-binding proteins as oncogenes in human tumors. Environ Health Perspect. 1991 Jun; 93:17-8. McCormick F. PMID: 1773789; PMCID: PMC1568037.
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    353. Insulin stimulation of gene expression mediated by p21ras activation. EMBO J. 1991 May; 10(5):1103-9. Burgering BM, Medema RH, Maassen JA, van de Wetering ML, van der Eb AJ, McCormick F, Bos JL. PMID: 2022184; PMCID: PMC452763.
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    354. Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids. Science. 1991 Apr 26; 252(5005):576-9. Han JW, McCormick F, Macara IG. PMID: 1902323.
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    355. Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Mol Cell Biol. 1991 Apr; 11(4):1804-12. Moran MF, Polakis P, McCormick F, Pawson T, Ellis C. PMID: 2005883; PMCID: PMC359849.
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    356. The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. Mol Cell Biol. 1991 Mar; 11(3):1523-30. Buss JE, Quilliam LA, Kato K, Casey PJ, Solski PA, Wong G, Clark R, McCormick F, Bokoch GM, Der CJ. PMID: 1899909; PMCID: PMC369437.
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    357. The GTPase superfamily: conserved structure and molecular mechanism. Nature. 1991 Jan 10; 349(6305):117-27. Bourne HR, Sanders DA, McCormick F. PMID: 1898771.
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    358. Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):239-43. Polakis PG, Rubinfeld B, Evans T, McCormick F. PMID: 1846040; PMCID: PMC50785.
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    359. Regulators and effectors of ras proteins. Annu Rev Cell Biol. 1991; 7:601-32. Bollag G, McCormick F. PMID: 1667084.
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    360. Regulation of ras p21 by GTPase activating proteins. Cold Spring Harb Symp Quant Biol. 1991; 56:237-41. McCormick F, Martin GA, Clark R, Bollag G, Polakis P. PMID: 1668082.
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    361. Purification, characterization, and western blot analysis of human GTPase-activating protein from native and recombinant sources. J Biol Chem. 1990 Dec 15; 265(35):21922-8. Halenbeck R, Crosier WJ, Clark R, McCormick F, Koths K. PMID: 2123878.
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    362. Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein. J Clin Endocrinol Metab. 1990 Dec; 71(6):1416-20. Landis CA, Harsh G, Lyons J, Davis RL, McCormick F, Bourne HR. PMID: 2121775.
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    363. The GTPase superfamily: a conserved switch for diverse cell functions. Nature. 1990 Nov 08; 348(6297):125-32. Bourne HR, Sanders DA, McCormick F. PMID: 2122258.
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    364. Oncogenes in multiple myeloma: point mutation of N-ras. Oncogene. 1990 Nov; 5(11):1659-63. Paquette RL, Berenson J, Lichtenstein A, McCormick F, Koeffler HP. PMID: 2267133.
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    365. Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. Mol Cell Biol. 1990 Nov; 10(11):5977-82. Munemitsu S, Innis MA, Clark R, McCormick F, Ullrich A, Polakis P. PMID: 2122236; PMCID: PMC361395.
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    366. The world according to GAP. Oncogene. 1990 Sep; 5(9):1281-3. McCormick F. PMID: 1699195.
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    367. Suppression of c-ras transformation by GTPase-activating protein. Nature. 1990 Aug 23; 346(6286):754-6. Zhang K, DeClue JE, Vass WC, Papageorge AG, McCormick F, Lowy DR. PMID: 2201922.
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    368. Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product. Science. 1990 Jul 13; 249(4965):169-71. Frech M, John J, Pizon V, Chardin P, Tavitian A, Clark R, McCormick F, Wittinghofer A. PMID: 2164710.
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    369. Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins. Mol Cell Biol. 1990 Jun; 10(6):2901-8. Quilliam LA, Der CJ, Clark R, O'Rourke EC, Zhang K, McCormick F, Bokoch GM. PMID: 2160589; PMCID: PMC360652.
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    370. ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels. Cell. 1990 Jun 01; 61(5):769-76. Yatani A, Okabe K, Polakis P, Halenbeck R, McCormick F, Brown AM. PMID: 2188736.
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    371. PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell. 1990 Apr 06; 61(1):125-33. Kaplan DR, Morrison DK, Wong G, McCormick F, Williams LT. PMID: 2156626.
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    372. GTP binding and growth control. Curr Opin Cell Biol. 1990 Apr; 2(2):181-4. McCormick F. PMID: 2141992.
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    373. Retrospective analysis of ras gene activation in myeloid leukemic cells. Oncogene. 1990 Apr; 5(4):583-7. Lübbert M, Jonas D, Miller CW, Herrmann F, Mertelsmann R, McCormick F, Koeffler HP. PMID: 2183160.
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    374. N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis. Blood. 1990 Mar 01; 75(5):1163-9. Lübbert M, Mirro J, Miller CW, Kahan J, Isaac G, Kitchingman G, Mertelsmann R, Herrmann F, McCormick F, Koeffler HP. PMID: 2407301.
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    375. RAS mutations in patients following cytotoxic therapy for lymphoma. Oncogene. 1990 Mar; 5(3):411-6. Carter G, Hughes DC, Clark RE, McCormick F, Jacobs A, Whittaker JA, Padua RA. PMID: 2179819.
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    376. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature. 1990 Jan 25; 343(6256):377-81. Ellis C, Moran M, McCormick F, Pawson T. PMID: 1689011.
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    377. GAP as ras effector or negative regulator? Mol Carcinog. 1990; 3(4):185-7. McCormick F. PMID: 2206281.
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    378. Genetic analysis of mammalian GAP expressed in yeast. Cell. 1989 Nov 17; 59(4):681-6. Ballester R, Michaeli T, Ferguson K, Xu HP, McCormick F, Wigler M. PMID: 2684416.
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    379. Production of and responsiveness to transforming growth factor-beta in normal and oncogene-transformed human mammary epithelial cells. Cancer Res. 1989 Nov 15; 49(22):6269-74. Valverius EM, Walker-Jones D, Bates SE, Stampfer MR, Clark R, McCormick F, Dickson RB, Lippman ME. PMID: 2553252.
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    380. Gasp: not just another oncogene. Nature. 1989 Aug 31; 340(6236):678-9. McCormick F. PMID: 2505083.
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    381. Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells. Cancer Res. 1989 Aug 01; 49(15):4258-63. Sommers CL, Walker-Jones D, Heckford SE, Worland P, Valverius E, Clark R, McCormick F, Stampfer M, Abularach S, Gelmann EP. PMID: 2472876.
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    382. Human bladder and colon carcinomas contain activated ras p21. Specific detection of twelfth codon mutants. Cancer. 1989 Jun 01; 63(11):2177-81. Meyers FJ, Gumerlock PH, Kokoris SP, deVere White RW, McCormick F. PMID: 2655864.
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    383. Identification of resonances from an oncogenic activating locus of human N-RAS-encoded p21 protein using isotope-edited NMR. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):817-20. Burk SC, Papastavros MZ, McCormick F, Redfield AG. PMID: 2644645; PMCID: PMC286568.
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    384. ras GTPase activating protein: signal transmitter and signal terminator. Cell. 1989 Jan 13; 56(1):5-8. McCormick F. PMID: 2535967.
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    385. Analysis of RAS oncogene mutations in human lymphoid malignancies. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9268-72. Neri A, Knowles DM, Greco A, McCormick F, Dalla-Favera R. PMID: 3057505; PMCID: PMC282720.
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    386. Transformation of human mammary epithelial cells by oncogenic retroviruses. Cancer Res. 1988 Aug 15; 48(16):4689-94. Clark R, Stampfer MR, Milley R, O'Rourke E, Walen KH, Kriegler M, Kopplin J, McCormick F. PMID: 3293776.
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    387. RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation. Leukemia. 1988 Aug; 2(8):503-10. Padua RA, Carter G, Hughes D, Gow J, Farr C, Oscier D, McCormick F, Jacobs A. PMID: 3166076.
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    388. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science. 1988 Apr 22; 240(4851):518-21. Adari H, Lowy DR, Willumsen BM, Der CJ, McCormick F. PMID: 2833817.
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    389. Functional properties of proteins coded by three human alpha-interferon genes and a pseudogene. Cancer Res. 1988 Apr 01; 48(7):1763-70. Creasey AA, Vitt CR, Herst C, O'Rourke E, Doyle L, Innis MA, McCabe PC, McCormick F, Milley R, Lin LS, et al. PMID: 2964896.
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    390. Interaction of ras p21 proteins with GTPase activating protein. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:849-54. McCormick F, Adari H, Trahey M, Halenbeck R, Koths K, Martin GA, Crosier WJ, Watt K, Rubinfeld B, Wong G. PMID: 2855502.
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    391. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science. 1987 Oct 23; 238(4826):542-5. Trahey M, McCormick F. PMID: 2821624.
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    392. Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells. J Cell Physiol Suppl. 1987; Suppl 5:69-73. Bar-Sagi D, McCormick F, Milley RJ, Feramisco JR. PMID: 3316255.
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    393. Biochemical and biological properties of the human N-ras p21 protein. Mol Cell Biol. 1987 Jan; 7(1):541-4. Trahey M, Milley RJ, Cole GE, Innis M, Paterson H, Marshall CJ, Hall A, McCormick F. PMID: 3550423; PMCID: PMC365100.
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    394. Detection of activated Mr 21,000 protein, the product of ras oncogenes, using antibodies with specificity for amino acid 12. Cancer Res. 1986 Dec; 46(12 Pt 1):6029-33. Wong G, Arnheim N, Clark R, McCabe P, Innis M, Aldwin L, Nitecki D, McCormick F. PMID: 3490906.
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    395. Genetic and biochemical analysis of ras p21 structure. Symp Fundam Cancer Res. 1986; 39:137-42. McCormick F, Levenson C, Cole G, Innis M, Clark R. PMID: 3321304.
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    396. Procedures for expression, modification, and analysis of human fibroblast interferon (IFN-beta) genes in heterologous cells. Methods Enzymol. 1986; 119:397-403. Innis MA, McCormick F. PMID: 3531770.
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    397. Antibodies specific for amino acid 12 of the ras oncogene product inhibit GTP binding. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5280-4. Clark R, Wong G, Arnheim N, Nitecki D, McCormick F. PMID: 3927300; PMCID: PMC390551.
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    398. Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein. Nature. 1985 Apr 18-24; 314(6012):639-42. Feramisco JR, Clark R, Wong G, Arnheim N, Milley R, McCormick F. PMID: 2581140.
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    399. Inhibition of protein synthesis stimulates the transcription of human beta-interferon genes in Chinese hamster ovary cells. Proc Natl Acad Sci U S A. 1984 Jul; 81(13):3964-8. Ringold GM, Dieckmann B, Vannice JL, Trahey M, McCormick F. PMID: 6330726; PMCID: PMC345348.
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    400. Inducible expression of amplified human beta interferon genes in CHO cells. Mol Cell Biol. 1984 Jan; 4(1):166-72. McCormick F, Trahey M, Innis M, Dieckmann B, Ringold G. PMID: 6700582; PMCID: PMC368671.
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    401. SV40 T antigen binds specifically to a cellular 53 K protein in vitro. Nature. 1981 Jul 02; 292(5818):63-5. McCormick F, Clark R, Harlow E, Tjian R. PMID: 6268984.
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    402. Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells. J Virol. 1980 Apr; 34(1):213-24. McCormick F, Harlow E. PMID: 6246255; PMCID: PMC288687.
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    403. T antigens of SV40-transformed cells. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:171-8. McCormick F, Chaudry F, Harvey R, Smith R, Rigby PW, Paucha E, Smith AE. PMID: 6253131.
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    404. Kinetics of polyamine synthesis and turnover in mouse fibroblasts. Biochem J. 1978 Aug 15; 174(2):427-34. McCormick F. PMID: 708395; PMCID: PMC1185931.
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