Frank McCormick, PhD, FRS

Title(s)Professor, HDF Comprehensive Cancer Ctr
SchoolSchool of Medicine
Address1450 Third Street, #371
San Francisco CA 94158
Phone415-502-1707
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    Collapse Overview
    Frank McCormick, PhD, FRS, is a Professor in the UCSF Helen Diller Family Comprehensive Cancer Center. Prior to joining the UCSF faculty, Dr. McCormick pursued cancer-related work with several Bay Area biotechnology firms and held positions with Cetus Corporation (Director of Molecular Biology, 1981-1990; Vice President of Research, 1990-1991) and Chiron Corporation, where he was Vice President of Research from 1991 to 1992. In 1992 he founded Onyx Pharmaceuticals, a company dedicated to developing new cancer therapies, and served as its Chief Scientific Officer until 1996. At Onyx Pharmaceuticals, he initiated and led drug discovery efforts that led to the approval of Sorafenib in 2005 for treatment of renal cell cancer, and for liver cancer in 2007, and the approval of ONYX-015 in 2006 in China for treatment of nasopharyngeal cancer. Sorafenib is being tested in multiple indications worldwide. In addition, Dr. McCormick’s group led to the identification of a CDK4 kinase inhibitor. Dr. McCormick's current research interests center on the fundamental differences between normal and cancer cells that can allow the discovery of novel therapeutic strategies.

    Dr. McCormick holds the David A. Wood Chair of Tumor Biology and Cancer Research at UCSF. Dr. McCormick is the author of over 285 scientific publications and holds 20 issued patents. He also served as President, 2012-2013 for the American Association for Cancer Research (AACR). More recently, he has taken a leadership role at the Frederick National Lab for Cancer Research, overseeing an NCI supported national effort to develop therapies against Ras-driven cancers. These cancers include most pancreatic cancers, and many colorectal and lung cancers, and are amongst the most difficult cancers to treat.

    Collapse Research 
    Collapse Research Activities and Funding
    Biodesy Delta System for San Francisco Bay Area Region
    NIH S10OD023482Mar 15, 2017 - Mar 14, 2018
    Role: Principal Investigator
    New Ways of Targeting K-Ras
    NIH R35CA197709Apr 1, 2016 - Mar 31, 2023
    Role: Principal Investigator
    Bay Area Cancer Target Discovery and Development Network
    NIH U01CA168370May 1, 2012 - Apr 30, 2017
    Role: Co-Principal Investigator
    Cancer Center Support Grant
    NIH P30CA082103Aug 5, 1999 - May 31, 2023
    Role: Co-Principal Investigator
    Bio-Organic Biomedical Mass Spectrometry Resource
    NIH P41RR001614Mar 1, 1982 - May 31, 2015
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. The prominent pervasive oncogenic role and tissue specific permissiveness of RAS gene mutations. Sci Rep. 2024 10 26; 14(1):25452. Yi M, Soppet D, McCormick F, Nissley DV. PMID: 39455841; PMCID: PMC11511894.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity. bioRxiv. 2024 Oct 25. Kwon JJ, Dilly J, Liu S, Kim E, Bian Y, Dharmaiah S, Tran TH, Kapner KS, Ly SH, Yang X, Rabara D, Waybright TJ, Giacomelli AO, Hong AL, Misek S, Wang B, Ravi A, Doench JG, Beroukhim R, Lemke CT, Haigis KM, Esposito D, Root DE, Nissley DV, Stephen AG, McCormick F, Simanshu DK, Hahn WC, Aguirre AJ. PMID: 39484452; PMCID: PMC11526993.
      View in: PubMed   Mentions:
    3. Inhibition and degradation of NRAS with a pan-NRAS monobody. Oncogene. 2024 Oct 08. Whaby M, Ketavarapu G, Koide A, Mazzei M, Mintoo M, Glasser E, Patel U, Nasarre C, Sale MJ, McCormick F, Koide S, O'Bryan JP. PMID: 39379700.
      View in: PubMed   Mentions:    Fields:    
    4. A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement. Anal Chem. 2024 04 02; 96(13):5223-5231. D'Ippolito RA, Rabara D, Blanco MA, Alberico E, Drew MR, Ramakrishnan N, Sontan D, Widmeyer SRT, Scheidemantle GM, Messing S, Turner D, Arkin M, Maciag AE, Stephen AG, Esposito D, McCormick F, Nissley DV, DeHart CJ. PMID: 38498381; PMCID: PMC10993199.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    5. Structural dynamics of RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric client interactions and key structural elements. Commun Biol. 2024 Mar 02; 7(1):260. Finci LI, Chakrabarti M, Gulten G, Finney J, Grose C, Fox T, Yang R, Nissley DV, McCormick F, Esposito D, Balius TE, Simanshu DK. PMID: 38431713; PMCID: PMC10908828.
      View in: PubMed   Mentions: 1  Translation:HumansCells
    6. Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties. Sci Adv. 2024 Feb 16; 10(7):eadj4137. Whitley MJ, Tran TH, Rigby M, Yi M, Dharmaiah S, Waybright TJ, Ramakrishnan N, Perkins S, Taylor T, Messing S, Esposito D, Nissley DV, McCormick F, Stephen AG, Turbyville T, Cornilescu G, Simanshu DK. PMID: 38354232.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR. J Biol Chem. 2024 Feb; 300(2):105650. Sharma AK, Pei J, Yang Y, Dyba M, Smith B, Rabara D, Larsen EK, Lightstone FC, Esposito D, Stephen AG, Wang B, Beltran PJ, Wallace E, Nissley DV, McCormick F, Maciag AE. PMID: 38237681; PMCID: PMC10877953.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    8. Functional interactions between neurofibromatosis tumor suppressors underlie Schwann cell tumor de-differentiation and treatment resistance. Nat Commun. 2024 Jan 12; 15(1):477. Vasudevan HN, Payne E, Delley CL, John Liu S, Mirchia K, Sale MJ, Lastella S, Nunez MS, Lucas CG, Eaton CD, Casey-Clyde T, Magill ST, Chen WC, Braunstein SE, Perry A, Jacques L, Reddy AT, Pekmezci M, Abate AR, McCormick F, Raleigh DR. PMID: 38216572; PMCID: PMC10786885.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    9. Progress in Targeting KRAS Directly. Methods Mol Biol. 2024; 2797:1-12. Nissley DV, Stephen AG, Yi M, McCormick F. PMID: 38570448.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Determining KRAS4B-Targeting Compound Specificity by Top-Down Mass Spectrometry. Methods Mol Biol. 2024; 2823:291-310. D'Ippolito RA, Scheidemantle GM, Rabara D, Abreu Blanco M, Ramakrishnan N, Widmeyer SRT, Messing S, Turner D, Maciag AE, Stephen AG, Esposito D, McCormick F, Nissley DV, DeHart CJ. PMID: 39052227.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    11. Long-term ecological research in freshwaters enabled by regional biodiversity collections, stable isotope analysis, and environmental informatics. Bioscience. 2023 Jul 29; 73(7):479-493. Turner TF, Bart HL, McCormick F, Besser AC, Bowes RE, Capps KA, DeArmon ES, Dillman CB, Driscoll KP, Dugger A, Hamilton GL, Harris PM, Hendrickson DA, Hoffman J, Knouft JH, Lepak RF, López-Fernández H, Montaña CG, Newsome SD, Pease AA, Smith WL, Taylor CA, Welicky RL. PMID: 37841229; PMCID: PMC10569117.
      View in: PubMed   Mentions:    Fields:    
    12. RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy. Sci Adv. 2023 07 14; 9(28):eadf4766. Cuevas-Navarro A, Wagner M, Van R, Swain M, Mo S, Columbus J, Allison MR, Cheng A, Messing S, Turbyville TJ, Simanshu DK, Sale MJ, McCormick F, Stephen AG, Castel P. PMID: 37450595; PMCID: PMC10348673.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D. Commun Biol. 2023 06 02; 6(1):594. Chao FA, Chan AH, Dharmaiah S, Schwieters CD, Tran TH, Taylor T, Ramakrishnan N, Esposito D, Nissley DV, McCormick F, Simanshu DK, Cornilescu G. PMID: 37268708; PMCID: PMC10238545.
      View in: PubMed   Mentions: 3  Translation:Cells
    14. RAS Signaling Gone Awry in the Skin: The Complex Role of RAS in Cutaneous Neurofibroma Pathogenesis, Emerging Biological Insights. J Invest Dermatol. 2023 08; 143(8):1358-1368. Rhodes SD, McCormick F, Cagan RL, Bakker A, Staedtke V, Ly I, Steensma MR, Lee SY, Romo CG, Blakeley JO, Sarin KY. PMID: 37245145; PMCID: PMC10409534.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    15. The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling. J Biol Chem. 2023 06; 299(6):104789. Lopez J, Bonsor DA, Sale MJ, Urisman A, Mehalko JL, Cabanski-Dunning M, Castel P, Simanshu DK, McCormick F. PMID: 37149146; PMCID: PMC10248553.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. Destabilizing NF1 variants act in a dominant negative manner through neurofibromin dimerization. Proc Natl Acad Sci U S A. 2023 Jan 31; 120(5):e2208960120. Young LC, Goldstein de Salazar R, Han SW, Huang ZYS, Merk A, Drew M, Darling J, Wall V, Grisshammer R, Cheng A, Allison MR, Sale MJ, Nissley DV, Esposito D, Ognjenovic J, McCormick F. PMID: 36689660; PMCID: PMC9945959.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation. Cancer Discov. 2022 10 05; 12(10):2434-2453. Chen S, Vedula RS, Cuevas-Navarro A, Lu B, Hogg SJ, Wang E, Benbarche S, Knorr K, Kim WJ, Stanley RF, Cho H, Erickson C, Singer M, Cui D, Tittley S, Durham BH, Pavletich TS, Fiala E, Walsh MF, Inoue D, Monette S, Taylor J, Rosen N, McCormick F, Lindsley RC, Castel P, Abdel-Wahab O. PMID: 35904492; PMCID: PMC9533010.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    18. Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Nat Struct Mol Biol. 2022 10; 29(10):966-977. Bonsor DA, Alexander P, Snead K, Hartig N, Drew M, Messing S, Finci LI, Nissley DV, McCormick F, Esposito D, Rodriguez-Viciana P, Stephen AG, Simanshu DK. PMID: 36175670; PMCID: PMC10365013.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    19. Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cells. Metabolites. 2022 Sep 02; 12(9). Kim SH, Song JH, Kim MJ, Song MG, Ku AA, Bandyopadhyay S, McCormick F, Kim SE. PMID: 36144235; PMCID: PMC9502772.
      View in: PubMed   Mentions:
    20. Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature. 2022 09; 609(7926):408-415. Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ. PMID: 35831509; PMCID: PMC9694338.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    21. ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. Mol Cell. 2022 07 07; 82(13):2443-2457.e7. Su W, Mukherjee R, Yaeger R, Son J, Xu J, Na N, Merna Timaul N, Hechtman J, Paroder V, Lin M, Mattar M, Qiu J, Chang Q, Zhao H, Zhang J, Little M, Adachi Y, Han SW, Taylor BS, Ebi H, Abdel-Wahab O, de Stanchina E, Rudin CM, Jänne PA, McCormick F, Yao Z, Rosen N. PMID: 35613620; PMCID: PMC9271631.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    22. Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs. Elife. 2022 04 25; 11. Cuevas-Navarro A, Rodriguez-Muñoz L, Grego-Bessa J, Cheng A, Rauen KA, Urisman A, McCormick F, Jimenez G, Castel P. PMID: 35467524; PMCID: PMC9068208.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    23. Targeting CD70 in cutaneous T-cell lymphoma using an antibody-drug conjugate in patient-derived xenograft models. Blood Adv. 2022 04 12; 6(7):2290-2302. Wu CH, Wang L, Yang CY, Wen KW, Hinds B, Gill R, McCormick F, Moasser M, Pincus L, Ai WZ. PMID: 34872108; PMCID: PMC9006301.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    24. More to the RAS Story: KRASG12C Inhibition, Resistance Mechanisms, and Moving Beyond KRASG12C. Am Soc Clin Oncol Educ Book. 2022 Apr; 42:1-13. Lietman CD, Johnson ML, McCormick F, Lindsay CR. PMID: 35561303.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    25. RAS at 40: Update from the RAS Initiative. Cancer Discov. 2022 04 01; 12(4):895-898. Nissley DV, McCormick F. PMID: 35046096.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    26. Insights into the Cross Talk between Effector and Allosteric Lobes of KRAS from Methyl Conformational Dynamics. J Am Chem Soc. 2022 03 09; 144(9):4196-4205. Chao FA, Dharmaiah S, Taylor T, Messing S, Gillette W, Esposito D, Nissley DV, McCormick F, Byrd RA, Simanshu DK, Cornilescu G. PMID: 35213144; PMCID: PMC10430694.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    27. Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors. Proc Natl Acad Sci U S A. 2022 02 01; 119(5). Lai LP, Fer N, Burgan W, Wall VE, Xu B, Soppet D, Esposito D, Nissley DV, McCormick F. PMID: 35091470; PMCID: PMC8812530.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    28. Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins. Proc Natl Acad Sci U S A. 2022 01 04; 119(1). Ingólfsson HI, Neale C, Carpenter TS, Shrestha R, López CA, Tran TH, Oppelstrup T, Bhatia H, Stanton LG, Zhang X, Sundram S, Di Natale F, Agarwal A, Dharuman G, Kokkila Schumacher SIL, Turbyville T, Gulten G, Van QN, Goswami D, Jean-Francois F, Agamasu C, Hettige JJ, Travers T, Sarkar S, Surh MP, Yang Y, Moody A, Liu S, Van Essen BC, Voter AF, Ramanathan A, Hengartner NW, Simanshu DK, Stephen AG, Bremer PT, Gnanakaran S, Glosli JN, Lightstone FC, McCormick F, Nissley DV, Streitz FH. PMID: 34983849; PMCID: PMC8740753.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    29. Cost Structures of US Organ Procurement Organizations. Transplantation. 2021 12 01; 105(12):2612-2619. Held PJ, Bragg-Gresham JL, Peters TG, McCormick F, Chertow G, Vaughan WP, Roberts JP. PMID: 33988344.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. NMR 1H, 13C, 15N backbone resonance assignments of the T35S and oncogenic T35S/Q61L mutants of human KRAS4b in the active, GppNHp-bound conformation. Biomol NMR Assign. 2022 04; 16(1):1-8. Sharma AK, Dyba M, Tonelli M, Smith B, Gillette WK, Esposito D, Nissley DV, McCormick F, Maciag AE. PMID: 34686998; PMCID: PMC9068649.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    31. A brief history of RAS and the RAS Initiative. Adv Cancer Res. 2022; 153:1-27. McCormick F. PMID: 35101227.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    32. RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity. Proc Natl Acad Sci U S A. 2021 08 17; 118(33). Castel P, Dharmaiah S, Sale MJ, Messing S, Rizzuto G, Cuevas-Navarro A, Cheng A, Trnka MJ, Urisman A, Esposito D, Simanshu DK, McCormick F. PMID: 34380736; PMCID: PMC8379911.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    33. UDP-glucose pyrophosphorylase 2, a regulator of glycogen synthesis and glycosylation, is critical for pancreatic cancer growth. Proc Natl Acad Sci U S A. 2021 08 03; 118(31). Wolfe AL, Zhou Q, Toska E, Galeas J, Ku AA, Koche RP, Bandyopadhyay S, Scaltriti M, Lebrilla CB, McCormick F, Kim SE. PMID: 34330832; PMCID: PMC8346792.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    34. Inhibition of MET Signaling with Ficlatuzumab in Combination with Chemotherapy in Refractory AML: Clinical Outcomes and High-Dimensional Analysis. Blood Cancer Discov. 2021 09; 2(5):434-449. Wang VE, Blaser BW, Patel RK, Behbehani GK, Rao AA, Durbin-Johnson B, Jiang T, Logan AC, Settles M, Mannis GN, Olin R, Damon LE, Martin TG, Sayre PH, Gaensler KM, McMahon E, Flanders M, Weinberg V, Ye CJ, Carbone DP, Munster PN, Fragiadakis GK, McCormick F, Andreadis C. PMID: 34514432; PMCID: PMC8425277.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    35. A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness. Front Cell Dev Biol. 2021; 9:665673. Okutachi S, Manoharan GB, Kiriazis A, Laurini C, Catillon M, McCormick F, Yli-Kauhaluoma J, Abankwa D. PMID: 34307350; PMCID: PMC8296985.
      View in: PubMed   Mentions: 8  
    36. The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression. Curr Biol. 2021 09 13; 31(17):3915-3924.e9. Cuevas-Navarro A, Van R, Cheng A, Urisman A, Castel P, McCormick F. PMID: 34237269; PMCID: PMC8440430.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    37. Targeted mass spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP Kinase, and AKT signaling. Cell Rep Methods. 2021 07 26; 1(3). Whiteaker JR, Sharma K, Hoffman MA, Kuhn E, Zhao L, Cocco AR, Schoenherr RM, Kennedy JJ, Voytovich U, Lin C, Fang B, Bowers K, Whiteley G, Colantonio S, Bocik W, Roberts R, Hiltke T, Boja E, Rodriguez H, McCormick F, Holderfield M, Carr SA, Koomen JM, Paulovich AG. PMID: 34671754; PMCID: PMC8525888.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    38. Estimated impact of novel coronavirus-19 and transplant center inactivity on end-stage renal disease-related patient mortality in the United States. Clin Transplant. 2021 08; 35(8):e14292. Peters TG, Bragg-Gresham JL, Klopstock AC, Roberts JP, Chertow G, McCormick F, Held PJ. PMID: 33749935; PMCID: PMC8250232.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    39. RAS-targeted therapies. Nat Rev Drug Discov. 2021 May 14. Moore AR, Rosenberg SC, McCormick F, Malek S. PMID: 33990767.
      View in: PubMed   Mentions: 6     Fields:    
    40. Sensitivity of Oncogenic KRAS-Expressing Cells to CDK9 Inhibition. SLAS Discov. 2021 08; 26(7):922-932. Lai LP, Brel V, Sharma K, Frappier J, Le-Henanf N, Vivet B, Muzet N, Schell E, Morales R, Rooney E, Basse N, Yi M, Lacroix F, Holderfield M, Englaro W, Marcireau C, Debussche L, Nissley DV, McCormick F. PMID: 33896272; PMCID: PMC8791284.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    41. Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nat Genet. 2021 05; 53(5):707-718. Inoue D, Polaski JT, Taylor J, Castel P, Chen S, Kobayashi S, Hogg SJ, Hayashi Y, Pineda JMB, El Marabti E, Erickson C, Knorr K, Fukumoto M, Yamazaki H, Tanaka A, Fukui C, Lu SX, Durham BH, Liu B, Wang E, Mehta S, Zakheim D, Garippa R, Penson A, Chew GL, McCormick F, Bradley RK, Abdel-Wahab O. PMID: 33846634; PMCID: PMC8177065.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    42. The Metabolic Landscape of RAS-Driven Cancers from biology to therapy. Nat Cancer. 2021 03; 2(3):271-283. Mukhopadhyay S, Vander Heiden MG, McCormick F. PMID: 33870211; PMCID: PMC8045781.
      View in: PubMed   Mentions: 121     Fields:    Translation:Humans
    43. Correction: DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs. J Biol Chem. 2021 Jan-Jun; 296:100380. Castel P, Holtz-Morris A, Kwon Y, Suter BP, McCormick F. PMID: 33837738; PMCID: PMC7949137.
      View in: PubMed   Mentions:    Fields:    
    44. KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun. 2021 02 19; 12(1):1176. Tran TH, Chan AH, Young LC, Bindu L, Neale C, Messing S, Dharmaiah S, Taylor T, Denson JP, Esposito D, Nissley DV, Stephen AG, McCormick F, Simanshu DK. PMID: 33608534; PMCID: PMC7895934.
      View in: PubMed   Mentions: 81     Fields:    Translation:HumansCells
    45. Author Correction: RAS-targeted therapies: is the undruggable drugged? Nat Rev Drug Discov. 2020 Dec; 19(12):902. Moore AR, Rosenberg SC, McCormick F, Malek S. PMID: 33082552.
      View in: PubMed   Mentions: 12     Fields:    
    46. Reducing the Shortage of Transplant Kidneys: A Lost Opportunity for the US Health Resources and Services Administration (HRSA). Am J Kidney Dis. 2021 06; 77(6):963-966. McCormick F, Held PJ, Chertow GM, Peters TG, Roberts JP. PMID: 33271212.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    47. DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs. J Biol Chem. 2021 Jan-Jun; 296:100023. Castel P, Holtz-Morris A, Kwon Y, Suter BP, McCormick F. PMID: 33410398; PMCID: PMC7949039.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    48. SPRED proteins and their roles in signal transduction, development, and malignancy. Genes Dev. 2020 11 01; 34(21-22):1410-1421. Lorenzo C, McCormick F. PMID: 33872193; PMCID: PMC7608746.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    49. Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway. Mol Syst Biol. 2020 10; 16(10):e9518. Gillies TE, Pargett M, Silva JM, Teragawa CK, McCormick F, Albeck JG. PMID: 33073539; PMCID: PMC7569415.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    50. Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24258-24268. Van QN, López CA, Tonelli M, Taylor T, Niu B, Stanley CB, Bhowmik D, Tran TH, Frank PH, Messing S, Alexander P, Scott D, Ye X, Drew M, Chertov O, Lösche M, Ramanathan A, Gross ML, Hengartner NW, Westler WM, Markley JL, Simanshu DK, Nissley DV, Gillette WK, Esposito D, McCormick F, Gnanakaran S, Heinrich F, Stephen AG. PMID: 32913056; PMCID: PMC7533834.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    51. The molecular functions of RIT1 and its contribution to human disease. Biochem J. 2020 08 14; 477(15):2755-2770. Van R, Cuevas-Navarro A, Castel P, McCormick F. PMID: 32766847; PMCID: PMC7787054.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    52. Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Rep. 2020 07 21; 32(3):107909. Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK. PMID: 32697994; PMCID: PMC7437355.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    53. Cutaneous T-Cell Lymphoma PDX Drug Screening Platform Identifies Cooperation between Inhibitions of PI3Kα/δ and HDAC. J Invest Dermatol. 2021 02; 141(2):364-373. Wu CH, Yang CY, Wang L, Gao HX, Rakhshandehroo T, Afghani S, Pincus L, Balassanian R, Rubenstein J, Gill R, Bandyopadhyay S, McCormick F, Moasser M, Ai WZ. PMID: 32603749; PMCID: PMC10286854.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    54. ssGSEA score-based Ras dependency indexes derived from gene expression data reveal potential Ras addiction mechanisms with possible clinical implications. Sci Rep. 2020 06 24; 10(1):10258. Yi M, Nissley DV, McCormick F, Stephens RM. PMID: 32581224; PMCID: PMC7314760.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    55. RAS-targeted therapies: is the undruggable drugged? Nat Rev Drug Discov. 2020 08; 19(8):533-552. Moore AR, Rosenberg SC, McCormick F, Malek S. PMID: 32528145; PMCID: PMC7809886.
      View in: PubMed   Mentions: 403     Fields:    Translation:HumansAnimals
    56. Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility. Nat Commun. 2020 05 12; 11(1):2375. Ku AA, Hu HM, Zhao X, Shah KN, Kongara S, Wu D, McCormick F, Balmain A, Bandyopadhyay S. PMID: 32398776; PMCID: PMC7217969.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    57. The duality of human oncoproteins: drivers of cancer and congenital disorders. Nat Rev Cancer. 2020 07; 20(7):383-397. Castel P, Rauen KA, McCormick F. PMID: 32341551; PMCID: PMC7787056.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    58. The small molecule BI-2852 induces a nonfunctional dimer of KRAS. Proc Natl Acad Sci U S A. 2020 02 18; 117(7):3363-3364. Tran TH, Alexander P, Dharmaiah S, Agamasu C, Nissley DV, McCormick F, Esposito D, Simanshu DK, Stephen AG, Balius TE. PMID: 32047043; PMCID: PMC7035607.
      View in: PubMed   Mentions: 33     Fields:    Translation:Cells
    59. Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior. Elife. 2020 01 20; 9. Goswami D, Yang Y, Gudla PR, Columbus J, Worthy K, Rigby M, Wheeler M, Mukhopadhyay S, Powell K, Burgan W, Wall V, Esposito D, Simanshu DK, Lightstone FC, Nissley DV, McCormick F, Turbyville T. PMID: 31958057; PMCID: PMC7060043.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    60. Sticking it to KRAS: Covalent Inhibitors Enter the Clinic. Cancer Cell. 2020 01 13; 37(1):3-4. McCormick F. PMID: 31951561; PMCID: PMC7891852.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    61. Advancing RAS/RASopathy therapies: An NCI-sponsored intramural and extramural collaboration for the study of RASopathies. Am J Med Genet A. 2020 04; 182(4):866-876. Gross AM, Frone M, Gripp KW, Gelb BD, Schoyer L, Schill L, Stronach B, Biesecker LG, Esposito D, Hernandez ER, Legius E, Loh ML, Martin S, Morrison DK, Rauen KA, Wolters PL, Zand D, McCormick F, Savage SA, Stewart DR, Widemann BC, Yohe ME. PMID: 31913576; PMCID: PMC7456498.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    62. Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers. Cancer Res. 2020 04 15; 80(8):1630-1643. Mukhopadhyay S, Goswami D, Adiseshaiah PP, Burgan W, Yi M, Guerin TM, Kozlov SV, Nissley DV, McCormick F. PMID: 31911550; PMCID: PMC7185043.
      View in: PubMed   Mentions: 120     Fields:    Translation:HumansAnimalsCells
    63. Biochemical and structural analyses reveal that the tumor suppressor neurofibromin (NF1) forms a high-affinity dimer. J Biol Chem. 2020 01 24; 295(4):1105-1119. Sherekar M, Han SW, Ghirlando R, Messing S, Drew M, Rabara D, Waybright T, Juneja P, O'Neill H, Stanley CB, Bhowmik D, Ramanathan A, Subramaniam S, Nissley DV, Gillette W, McCormick F, Esposito D. PMID: 31836666; PMCID: PMC6983858.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    64. The sixth international RASopathies symposium: Precision medicine-From promise to practice. Am J Med Genet A. 2020 03; 182(3):597-606. Gripp KW, Schill L, Schoyer L, Stronach B, Bennett AM, Blaser S, Brown A, Burdine R, Burkitt-Wright E, Castel P, Darilek S, Dias A, Dyer T, Ellis M, Erickson G, Gelb BD, Green T, Gross A, Ho A, Holder JL, Inoue SI, Jelin AC, Kennedy A, Klein R, Kontaridis MI, Magoulas P, McConnell DB, McCormick F, Neel BG, Prada CE, Rauen KA, Roberts A, Rodriguez-Viciana P, Rosen N, Rumbaugh G, Sablina A, Solman M, Tartaglia M, Thomas A, Timmer WC, Venkatachalam K, Walsh KS, Wolters PL, Yi JS, Zenker M, Ratner N. PMID: 31825160; PMCID: PMC7021559.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    65. The cost of procuring deceased donor kidneys: Evidence from OPO cost reports 2013-2017. Am J Transplant. 2020 04; 20(4):1087-1094. Held PJ, Bragg-Gresham JL, Peters T, Chertow GM, McCormick F, Roberts JP. PMID: 31667990.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    66. Romidepsin Plus Liposomal Doxorubicin Is Safe and Effective in Patients with Relapsed or Refractory T-Cell Lymphoma: Results of a Phase I Dose-Escalation Study. Clin Cancer Res. 2020 03 01; 26(5):1000-1008. Vu K, Wu CH, Yang CY, Zhan A, Cavallone E, Berry W, Heeter P, Pincus L, Wieduwilt MJ, William BM, Andreadis C, Kaplan LK, McCormick F, Porcu P, Brammer JE, Ai WZ. PMID: 31772119.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCellsCTClinical Trials
    67. KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. Proc Natl Acad Sci U S A. 2019 10 29; 116(44):22122-22131. Rabara D, Tran TH, Dharmaiah S, Stephens RM, McCormick F, Simanshu DK, Holderfield M. PMID: 31611389; PMCID: PMC6825300.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    68. Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation. Clin Cancer Res. 2019 12 01; 25(23):7202-7217. Wang VE, Xue JY, Frederick DT, Cao Y, Lin E, Wilson C, Urisman A, Carbone DP, Flaherty KT, Bernards R, Lito P, Settleman J, McCormick F. PMID: 31515463; PMCID: PMC6891193.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    69. Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder. Proc Natl Acad Sci U S A. 2019 08 27; 116(35):17290-17297. Donohue E, Khorsand S, Mercado G, Varney KM, Wilder PT, Yu W, MacKerell AD, Alexander P, Van QN, Moree B, Stephen AG, Weber DJ, Salafsky J, McCormick F. PMID: 31399543; PMCID: PMC6717309.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    70. Removing Disincentives to Kidney Donation: A Quantitative Analysis. J Am Soc Nephrol. 2019 08; 30(8):1349-1357. McCormick F, Held PJ, Chertow GM, Peters TG, Roberts JP. PMID: 31345987; PMCID: PMC6683718.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    71. Structures of N-terminally processed KRAS provide insight into the role of N-acetylation. Sci Rep. 2019 07 19; 9(1):10512. Dharmaiah S, Tran TH, Messing S, Agamasu C, Gillette WK, Yan W, Waybright T, Alexander P, Esposito D, Nissley DV, McCormick F, Stephen AG, Simanshu DK. PMID: 31324887; PMCID: PMC6642148.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    72. Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer. Nat Commun. 2019 07 11; 10(1):3055. Wang MT, Fer N, Galeas J, Collisson EA, Kim SE, Sharib J, McCormick F. PMID: 31296870; PMCID: PMC6624260.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    73. Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors. Gene Ther. 2019 06; 26(6):277-286. Bai RY, Esposito D, Tam AJ, McCormick F, Riggins GJ, Wade Clapp D, Staedtke V. PMID: 31127187; PMCID: PMC6588423.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    74. RIT1 oncoproteins escape LZTR1-mediated proteolysis. Science. 2019 03 15; 363(6432):1226-1230. Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F. PMID: 30872527; PMCID: PMC6986682.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    75. KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner. Biophys J. 2019 03 19; 116(6):1049-1063. Agamasu C, Ghirlando R, Taylor T, Messing S, Tran TH, Bindu L, Tonelli M, Nissley DV, McCormick F, Stephen AG. PMID: 30846362; PMCID: PMC6428923.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    76. MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival. Proc Natl Acad Sci U S A. 2019 03 05; 116(10):4508-4517. Lee CS, Lee LC, Yuan TL, Chakka S, Fellmann C, Lowe SW, Caplen NJ, McCormick F, Luo J. PMID: 30709910; PMCID: PMC6410784.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    77. Progress in targeting RAS with small molecule drugs. Biochem J. 2019 01 31; 476(2):365-374. McCormick F. PMID: 30705085.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    78. Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane. J Biol Chem. 2019 02 08; 294(6):2193-2207. Lakshman B, Messing S, Schmid EM, Clogston JD, Gillette WK, Esposito D, Kessing B, Fletcher DA, Nissley DV, McCormick F, Stephen AG, Jean-Francois FL. PMID: 30559287; PMCID: PMC6369290.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    79. Would government compensation of living kidney donors exploit the poor? An empirical analysis. PLoS One. 2018; 13(11):e0205655. Held PJ, McCormick F, Chertow GM, Peters TG, Roberts JP. PMID: 30485269; PMCID: PMC6261427.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    80. Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nat Med. 2019 01; 25(1):111-118. Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S. PMID: 30478424; PMCID: PMC6324945.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    81. The Terrible Toll of the Kidney Shortage. J Am Soc Nephrol. 2018 12; 29(12):2775-2776. McCormick F, Held PJ, Chertow GM. PMID: 30420419; PMCID: PMC6287861.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    82. SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis. Proc Natl Acad Sci U S A. 2018 11 06; 115(45):E10576-E10585. Young LC, Hartig N, Boned Del Río I, Sari S, Ringham-Terry B, Wainwright JR, Jones GG, McCormick F, Rodriguez-Viciana P. PMID: 30348783; PMCID: PMC6233131.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    83. Proceedings of the fifth international RASopathies symposium: When development and cancer intersect. Am J Med Genet A. 2018 12; 176(12):2924-2929. Rauen KA, Schoyer L, Schill L, Stronach B, Albeck J, Andresen BS, Cavé H, Ellis M, Fruchtman SM, Gelb BD, Gibson CC, Gripp K, Hefner E, Huang WYC, Itkin M, Kerr B, Linardic CM, McMahon M, Oberlander B, Perlstein E, Ratner N, Rogers L, Schenck A, Shankar S, Shvartsman S, Stevenson DA, Stites EC, Stork PJS, Sun C, Therrien M, Ullian EM, Widemann BC, Yeh E, Zampino G, Zenker M, Timmer W, McCormick F. PMID: 30302932; PMCID: PMC6312476.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    84. Direct molecular dissection of tumor parenchyma from tumor stroma in tumor xenograft using mass spectrometry-based glycoproteomics. Oncotarget. 2018 May 29; 9(41):26431-26452. Ye X, Luke BT, Wei BR, Kaczmarczyk JA, Loncarek J, Dwyer JE, Johann DJ, Saul RG, Nissley DV, McCormick F, Whiteley GR, Blonder J. PMID: 29899869; PMCID: PMC5995176.
      View in: PubMed   Mentions: 4     Fields:    
    85. Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell. 2018 04 05; 173(2):321-337.e10. Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Bailey MH, Liang WW, Foltz SM, Shmulevich I, Ding L, Heins Z, Ochoa A, Gross B, Gao J, Zhang H, Kundra R, Kandoth C, Bahceci I, Dervishi L, Dogrusoz U, Zhou W, Shen H, Laird PW, Way GP, Greene CS, Liang H, Xiao Y, Wang C, Iavarone A, Berger AH, Bivona TG, Lazar AJ, Hammer GD, Giordano T, Kwong LN, McArthur G, Huang C, Tward AD, Frederick MJ, McCormick F, Meyerson M, Cancer Genome Atlas Research Network, Van Allen EM, Cherniack AD, Ciriello G, Sander C, Schultz N. PMID: 29625050; PMCID: PMC6070353.
      View in: PubMed   Mentions: 1387     Fields:    Translation:HumansCells
    86. Differential Effector Engagement by Oncogenic KRAS. Cell Rep. 2018 02 13; 22(7):1889-1902. Yuan TL, Amzallag A, Bagni R, Yi M, Afghani S, Burgan W, Fer N, Strathern LA, Powell K, Smith B, Waters AM, Drubin D, Thomson T, Liao R, Greninger P, Stein GT, Murchie E, Cortez E, Egan RK, Procter L, Bess M, Cheng KT, Lee CS, Lee LC, Fellmann C, Stephens R, Luo J, Lowe SW, Benes CH, McCormick F. PMID: 29444439; PMCID: PMC6343826.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    87. c-Raf in KRas Mutant Cancers: A Moving Target. Cancer Cell. 2018 02 12; 33(2):158-159. McCormick F. PMID: 29438690; PMCID: PMC6464632.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    88. Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nat Biotechnol. 2018 02; 36(2):170-178. Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT. PMID: 29334369; PMCID: PMC6072461.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    89. Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality. Nat Commun. 2017 12 19; 8(1):2200. Kitagawa M, Liao PJ, Lee KH, Wong J, Shang SC, Minami N, Sampetrean O, Saya H, Lingyun D, Prabhu N, Diam GK, Sobota R, Larsson A, Nordlund P, McCormick F, Ghosh S, Epstein DM, Dymock BW, Lee SH. PMID: 29259156; PMCID: PMC5736559.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    90. Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. Nature. 2017 11 09; 551(7679):247-250. Hangauer MJ, Viswanathan VS, Ryan MJ, Bole D, Eaton JK, Matov A, Galeas J, Dhruv HD, Berens ME, Schreiber SL, McCormick F, McManus MT. PMID: 29088702; PMCID: PMC5933935.
      View in: PubMed   Mentions: 650     Fields:    Translation:HumansAnimals
    91. Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. Sci Signal. 2017 Sep 26; 10(498). Waters AM, Ozkan-Dagliyan I, Vaseva AV, Fer N, Strathern LA, Hobbs GA, Tessier-Cloutier B, Gillette WK, Bagni R, Whiteley GR, Hartley JL, McCormick F, Cox AD, Houghton PJ, Huntsman DG, Philips MR, Der CJ. PMID: 28951536; PMCID: PMC5812265.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    92. RAS Proteins and Their Regulators in Human Disease. Cell. 2017 Jun 29; 170(1):17-33. Simanshu DK, Nissley DV, McCormick F. PMID: 28666118; PMCID: PMC5555610.
      View in: PubMed   Mentions: 762     Fields:    Translation:HumansAnimalsCells
    93. Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras. ACS Chem Biol. 2017 07 21; 12(7):1956-1962. Novotny CJ, Hamilton GL, McCormick F, Shokat KM. PMID: 28530791; PMCID: PMC6070134.
      View in: PubMed   Mentions: 20     Fields:    Translation:Cells
    94. Tumor RAS Gene Expression Levels Are Influenced by the Mutational Status of RAS Genes and Both Upstream and Downstream RAS Pathway Genes. Cancer Inform. 2017; 16:1176935117711944. Stephens RM, Yi M, Kessing B, Nissley DV, McCormick F. PMID: 28634423; PMCID: PMC5467702.
      View in: PubMed   Mentions: 12  
    95. ETS-targeted therapy: can it substitute for MEK inhibitors? Clin Transl Med. 2017 Dec; 6(1):16. Tetsu O, McCormick F. PMID: 28474232; PMCID: PMC5418169.
      View in: PubMed   Mentions: 19     Fields:    
    96. Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient. Oral Oncol. 2017 06; 69:1-10. Wang SJ, Asthana S, van Zante A, Heaton CM, Phuchareon J, Stein L, Higuchi S, Kishimoto T, Chiu CY, Olshen AB, McCormick F, Tetsu O. PMID: 28559012; PMCID: PMC5479323.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    97. Comparative proteomics of a model MCF10A-KRasG12V cell line reveals a distinct molecular signature of the KRasG12V cell surface. Oncotarget. 2016 Dec 27; 7(52):86948-86971. Ye X, Chan KC, Waters AM, Bess M, Harned A, Wei BR, Loncarek J, Luke BT, Orsburn BC, Hollinger BD, Stephens RM, Bagni R, Martinko A, Wells JA, Nissley DV, McCormick F, Whiteley G, Blonder J. PMID: 27894102; PMCID: PMC5341332.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    98. Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):E6766-E6775. Dharmaiah S, Bindu L, Tran TH, Gillette WK, Frank PH, Ghirlando R, Nissley DV, Esposito D, McCormick F, Stephen AG, Simanshu DK. PMID: 27791178; PMCID: PMC5098621.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansCells
    99. The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7497-502. Dunzendorfer-Matt T, Mercado EL, Maly K, McCormick F, Scheffzek K. PMID: 27313208; PMCID: PMC4941445.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    100. The Fourth International Symposium on Genetic Disorders of the Ras/MAPK pathway. Am J Med Genet A. 2016 08; 170(8):1959-66. Stevenson DA, Schill L, Schoyer L, Andresen BS, Bakker A, Bayrak-Toydemir P, Burkitt-Wright E, Chatfield K, Elefteriou F, Elgersma Y, Fisher MJ, Franz D, Gelb BD, Goriely A, Gripp KW, Hardan AY, Keppler-Noreuil KM, Kerr B, Korf B, Leoni C, McCormick F, Plotkin SR, Rauen KA, Reilly K, Roberts A, Sandler A, Siegel D, Walsh K, Widemann BC. PMID: 27155140; PMCID: PMC4945362.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    101. K-Ras protein as a drug target. J Mol Med (Berl). 2016 Mar; 94(3):253-8. McCormick F. PMID: 26960760; PMCID: PMC4803814.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    102. Drug Resistance to EGFR Inhibitors in Lung Cancer. Chemotherapy. 2016; 61(5):223-35. Tetsu O, Hangauer MJ, Phuchareon J, Eisele DW, McCormick F. PMID: 26910730; PMCID: PMC4844777.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    103. ABO-Incompatible Kidney Transplants: Twice as Expensive, Half as Good. Am J Transplant. 2016 05; 16(5):1343-4. Held PJ, McCormick F. PMID: 26614637.
      View in: PubMed   Mentions: 3     Fields:    
    104. K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling. Cell. 2015 Nov 19; 163(5):1237-1251. Wang MT, Holderfield M, Galeas J, Delrosario R, To MD, Balmain A, McCormick F. PMID: 26590425.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansAnimalsCells
    105. Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions. Sci Rep. 2015 Nov 02; 5:15916. Gillette WK, Esposito D, Abreu Blanco M, Alexander P, Bindu L, Bittner C, Chertov O, Frank PH, Grose C, Jones JE, Meng Z, Perkins S, Van Q, Ghirlando R, Fivash M, Nissley DV, McCormick F, Holderfield M, Stephen AG. PMID: 26522388; PMCID: PMC4629113.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    106. AKT inactivation causes persistent drug tolerance to EGFR inhibitors. Pharmacol Res. 2015 Dec; 102:132-7. Tetsu O, Phuchareon J, Eisele DW, Hangauer MJ, McCormick F. PMID: 26453958.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    107. A Cost-Benefit Analysis of Government Compensation of Kidney Donors. Am J Transplant. 2016 Mar; 16(3):877-85. Held PJ, McCormick F, Ojo A, Roberts JP. PMID: 26474298; PMCID: PMC5057320.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    108. ETS1 inactivation causes innate drug resistance to EGFR inhibitors. Mol Cell Oncol. 2016 Mar; 3(2):e1078924. Tetsu O, Phuchareon J, Eisele DW, McCormick F. PMID: 27308601; PMCID: PMC4905380.
      View in: PubMed   Mentions: 4  
    109. EGFR inhibition evokes innate drug resistance in lung cancer cells by preventing Akt activity and thus inactivating Ets-1 function. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3855-63. Phuchareon J, McCormick F, Eisele DW, Tetsu O. PMID: 26150526; PMCID: PMC4517222.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    110. Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway. Proc Natl Acad Sci U S A. 2015 Jun 30; 112(26):7996-8001. Nan X, Tamgüney TM, Collisson EA, Lin LJ, Pitt C, Galeas J, Lewis S, Gray JW, McCormick F, Chu S. PMID: 26080442; PMCID: PMC4491781.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    111. Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions. Cancer Res. 2015 Jul 15; 75(14):2851-62. Fujita-Sato S, Galeas J, Truitt M, Pitt C, Urisman A, Bandyopadhyay S, Ruggero D, McCormick F. PMID: 25977330; PMCID: PMC4506276.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    112. KRAS as a Therapeutic Target. Clin Cancer Res. 2015 Apr 15; 21(8):1797-801. McCormick F. PMID: 25878360; PMCID: PMC4407814.
      View in: PubMed   Mentions: 155     Fields:    Translation:HumansAnimalsCells
    113. The potential of targeting Ras proteins in lung cancer. Expert Opin Ther Targets. 2015 Apr; 19(4):451-4. McCormick F. PMID: 25558943.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    114. Resistance to EGFR-targeted therapy by Ets-1 inactivation. Cell Cycle. 2015; 14(20):3211-2. Tetsu O, Eisele DW, McCormick F. PMID: 26313421; PMCID: PMC4825599.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    115. Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map. Cancer Discov. 2015 02; 5(2):154-67. Martins MM, Zhou AY, Corella A, Horiuchi D, Yau C, Rakhshandehroo T, Gordan JD, Levin RS, Johnson J, Jascur J, Shales M, Sorrentino A, Cheah J, Clemons PA, Shamji AF, Schreiber SL, Krogan NJ, Shokat KM, McCormick F, Goga A, Bandyopadhyay S. PMID: 25501949; PMCID: PMC4407699.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    116. Fatty Acid binding protein 7 is a molecular marker in adenoid cystic carcinoma of the salivary glands: implications for clinical significance. Transl Oncol. 2014 Dec; 7(6):780-7. Phuchareon J, Overdevest JB, McCormick F, Eisele DW, van Zante A, Tetsu O. PMID: 25500088; PMCID: PMC4311037.
      View in: PubMed   Mentions: 8  
    117. Social interactomes for enabling research communities. Cancer Discov. 2014 Nov; 4(11):1265-8. Guinney J, Dienstmann R, Ferté C, Friend S, McCormick F. PMID: 25367949.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    118. c-Kit Expression is Rate-Limiting for Stem Cell Factor-Mediated Disease Progression in Adenoid Cystic Carcinoma of the Salivary Glands. Transl Oncol. 2014 Oct; 7(5):537-45. Phuchareon J, van Zante A, Overdevest JB, McCormick F, Eisele DW, Tetsu O. PMID: 25389449; PMCID: PMC4225653.
      View in: PubMed   Mentions: 9  
    119. Oncogene mimicry as a mechanism of primary resistance to BRAF inhibitors. Cell Rep. 2014 Aug 21; 8(4):1037-48. Sos ML, Levin RS, Gordan JD, Oses-Prieto JA, Webber JT, Salt M, Hann B, Burlingame AL, McCormick F, Bandyopadhyay S, Shokat KM. PMID: 25127139; PMCID: PMC4294625.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    120. Development of siRNA payloads to target KRAS-mutant cancer. Cancer Discov. 2014 Oct; 4(10):1182-1197. Yuan TL, Fellmann C, Lee CS, Ritchie CD, Thapar V, Lee LC, Hsu DJ, Grace D, Carver JO, Zuber J, Luo J, McCormick F, Lowe SW. PMID: 25100204; PMCID: PMC4184972.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    121. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. Nat Rev Cancer. 2014 Jul; 14(7):455-67. Holderfield M, Deuker MM, McCormick F, McMahon M. PMID: 24957944; PMCID: PMC4250230.
      View in: PubMed   Mentions: 383     Fields:    Translation:HumansAnimals
    122. Unicompartmental knee arthroplasty versus high tibial osteotomy: United States practice patterns for the surgical treatment of unicompartmental arthritis. J Arthroplasty. 2014 Aug; 29(8):1586-9. Nwachukwu BU, McCormick FM, Schairer WW, Frank RM, Provencher MT, Roche MW. PMID: 24814891.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    123. Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell Metab. 2014 Apr 01; 19(4):694-701. Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR. PMID: 24703700; PMCID: PMC4294542.
      View in: PubMed   Mentions: 129     Fields:    Translation:HumansCells
    124. Dragging ras back in the ring. Cancer Cell. 2014 Mar 17; 25(3):272-81. Stephen AG, Esposito D, Bagni RK, McCormick F. PMID: 24651010.
      View in: PubMed   Mentions: 452     Fields:    Translation:HumansAnimalsCells
    125. Current status of evidence-based sports medicine. Arthroscopy. 2014 Mar; 30(3):362-71. Harris JD, Cvetanovich G, Erickson BJ, Abrams GD, Chahal J, Gupta AK, McCormick FM, Bach BR. PMID: 24581261.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    126. Vemurafenib cooperates with HPV to promote initiation of cutaneous tumors. Cancer Res. 2014 Apr 15; 74(8):2238-45. Holderfield M, Lorenzana E, Weisburd B, Lomovasky L, Boussemart L, Lacroix L, Tomasic G, Favre M, Vagner S, Robert C, Ghoddusi M, Daniel D, Pryer N, McCormick F, Stuart D. PMID: 24523442.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    127. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014; 9(2):e87220. Kashiyama T, Oda K, Ikeda Y, Shiose Y, Hirota Y, Inaba K, Makii C, Kurikawa R, Miyasaka A, Koso T, Fukuda T, Tanikawa M, Shoji K, Sone K, Arimoto T, Wada-Hiraike O, Kawana K, Nakagawa S, Matsuda K, McCormick F, Aburatani H, Yano T, Osuga Y, Fujii T. PMID: 24504419; PMCID: PMC3913610.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    128. Functional Performance Testing After Anterior Cruciate Ligament Reconstruction: A Systematic Review. Orthop J Sports Med. 2014 Jan; 2(1):2325967113518305. Abrams GD, Harris JD, Gupta AK, McCormick FM, Bush-Joseph CA, Verma NN, Cole BJ, Bach BR. PMID: 26535266; PMCID: PMC4555525.
      View in: PubMed   Mentions: 103  
    129. CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies. Am J Med Genet A. 2014 Mar; 164A(3):563-78. Widemann BC, Acosta MT, Ammoun S, Belzberg AJ, Bernards A, Blakeley J, Bretscher A, Cichowski K, Clapp DW, Dombi E, Evans GD, Ferner R, Fernandez-Valle C, Fisher MJ, Giovannini M, Gutmann DH, Hanemann CO, Hennigan R, Huson S, Ingram D, Kissil J, Korf BR, Legius E, Packer RJ, McClatchey AI, McCormick F, North K, Pehrsson M, Plotkin SR, Ramesh V, Ratner N, Schirmer S, Sherman L, Schorry E, Stevenson D, Stewart DR, Ullrich N, Bakker AC, Morrison H. PMID: 24443315; PMCID: PMC4150212.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    130. Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation. Cancer Discov. 2014 Feb; 4(2):186-99. Salt MB, Bandyopadhyay S, McCormick F. PMID: 24302555.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansCells
    131. High mobility group box 1 promotes tumor cell migration through epigenetic silencing of semaphorin 3A. Oncogene. 2014 Oct 30; 33(44):5151-62. Nehil M, Paquette J, Tokuyasu T, McCormick F. PMID: 24213571.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    132. Killing tumors by keeping ras and PI3' kinase apart. Cancer Cell. 2013 Nov 11; 24(5):562-3. Yuan TL, McCormick F. PMID: 24229705.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    133. Single-molecule superresolution imaging allows quantitative analysis of RAF multimer formation and signaling. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18519-24. Nan X, Collisson EA, Lewis S, Huang J, Tamgüney TM, Liphardt JT, McCormick F, Gray JW, Chu S. PMID: 24158481; PMCID: PMC3831949.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    134. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell. 2013 Oct 14; 24(4):450-65. Timmerman LA, Holton T, Yuneva M, Louie RJ, Padró M, Daemen A, Hu M, Chan DA, Ethier SP, van 't Veer LJ, Polyak K, McCormick F, Gray JW. PMID: 24094812; PMCID: PMC3931310.
      View in: PubMed   Mentions: 315     Fields:    Translation:HumansAnimalsCells
    135. MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):13845-50. Lyons J, Bastian BC, McCormick F. PMID: 23908401; PMCID: PMC3752210.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    136. RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation. Cancer Cell. 2013 May 13; 23(5):594-602. Holderfield M, Merritt H, Chan J, Wallroth M, Tandeske L, Zhai H, Tellew J, Hardy S, Hekmat-Nejad M, Stuart DD, McCormick F, Nagel TE. PMID: 23680146.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    137. An assessment of the quality of rotator cuff randomized controlled trials: utilizing the Jadad score and CONSORT criteria. J Shoulder Elbow Surg. 2013 Sep; 22(9):1180-5. McCormick F, Cvetanovich GL, Kim JM, Harris JD, Gupta AK, Abrams GD, Romeo AA, Provencher MT. PMID: 23510746.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    138. Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling. Cancer Discov. 2013 Jan; 3(1):112-23. Young A, Lou D, McCormick F. PMID: 23103856.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    139. A shared molecular mechanism underlies the human rasopathies Legius syndrome and Neurofibromatosis-1. Genes Dev. 2012 Jul 01; 26(13):1421-6. Stowe IB, Mercado EL, Stowe TR, Bell EL, Oses-Prieto JA, Hernández H, Burlingame AL, McCormick F. PMID: 22751498; PMCID: PMC3403010.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    140. Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas. PLoS One. 2012; 7(5):e37431. Shoji K, Oda K, Kashiyama T, Ikeda Y, Nakagawa S, Sone K, Miyamoto Y, Hiraike H, Tanikawa M, Miyasaka A, Koso T, Matsumoto Y, Wada-Hiraike O, Kawana K, Kuramoto H, McCormick F, Aburatani H, Yano T, Kozuma S, Taketani Y. PMID: 22662154; PMCID: PMC3360787.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    141. Cancer therapy based on oncogene addiction. J Surg Oncol. 2011 May 01; 103(6):464-7. McCormick F. PMID: 21480237.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    142. Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies. Am J Med Genet C Semin Med Genet. 2011 May 15; 157C(2):136-46. Rauen KA, Banerjee A, Bishop WR, Lauchle JO, McCormick F, McMahon M, Melese T, Munster PN, Nadaf S, Packer RJ, Sebolt-Leopold J, Viskochil DH. PMID: 21495172; PMCID: PMC4145816.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    143. Promoting growth for preterm infants following hospital discharge. Arch Dis Child Fetal Neonatal Ed. 2012 Jul; 97(4):F295-8. Morgan JA, Young L, McCormick FM, McGuire W. PMID: 21406452.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    144. Therapeutic strategies for targeting ras proteins. Genes Cancer. 2011 Mar; 2(3):359-72. Gysin S, Salt M, Young A, McCormick F. PMID: 21779505; PMCID: PMC3128641.
      View in: PubMed   Mentions: 168  
    145. Mutant onco-proteins as drug targets: successes, failures, and future prospects. Curr Opin Genet Dev. 2011 Feb; 21(1):29-33. McCormick F. PMID: 21236660.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    146. Mad2 inhibits the mitotic kinesin MKlp2. J Cell Biol. 2010 Dec 13; 191(6):1069-77. Lee SH, McCormick F, Saya H. PMID: 21149564; PMCID: PMC3002031.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    147. Comparison of oncolytic adenoviruses for selective eradication of oral cancer and pre-cancerous lesions. Gene Ther. 2010 Dec; 17(12):1517-24. van Zeeburg HJ, Huizenga A, Brink A, van den Doel PB, Zhu ZB, McCormick F, Brakenhoff RH, van Beusechem VW. PMID: 20686507.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    148. Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells. Virol J. 2010 Jul 08; 7:148. Lyle C, McCormick F. PMID: 20615244; PMCID: PMC2909962.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    149. Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator. Cancer Cell. 2010 Jun 15; 17(6):574-83. Ishida S, McCormick F, Smith-McCune K, Hanahan D. PMID: 20541702; PMCID: PMC2902369.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    150. The molecular pathology of cancer. Nat Rev Clin Oncol. 2010 May; 7(5):251-65. Harris TJ, McCormick F. PMID: 20351699.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    151. The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Mol Cell Biol. 2010 May; 30(9):2264-79. Phan VT, Ding VW, Li F, Chalkley RJ, Burlingame A, McCormick F. PMID: 20160012; PMCID: PMC2863595.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    152. What's new in neurofibromatosis? Proceedings from the 2009 NF Conference: new frontiers. Am J Med Genet A. 2010 Feb; 152A(2):269-83. Kissil JL, Blakeley JO, Ferner RE, Huson SM, Kalamarides M, Mautner VF, McCormick F, Morrison H, Packer R, Ramesh V, Ratner N, Rauen KA, Stevenson DA, Hunter-Schaedle K, North K. PMID: 20082461; PMCID: PMC2818482.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    153. How blocking Raf activates the MAPK pathway. Pigment Cell Melanoma Res. 2010 Apr; 23(2):187-9. McCormick F. PMID: 20128874.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    154. Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway. Oncogene. 2010 Apr 01; 29(13):1897-908. Murayama-Hosokawa S, Oda K, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K, Ikeda Y, Uehara Y, Fukayama M, McCormick F, Yano T, Taketani Y, Aburatani H. PMID: 20062086.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    155. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A. 2010 Jan; 152A(1):4-24. Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. PMID: 20014119; PMCID: PMC4051786.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    156. EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal. 2009 Jan 27; 2(55):ra4. Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. PMID: 19176518; PMCID: PMC2793677.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    157. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565-72. Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. PMID: 19147570; PMCID: PMC2737189.
      View in: PubMed   Mentions: 189     Fields:    Translation:HumansCells
    158. Ras signaling and therapies. Adv Cancer Res. 2009; 102:1-17. Young A, Lyons J, Miller AL, Phan VT, Alarcón IR, McCormick F. PMID: 19595305.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansCells
    159. Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint. Genes Dev. 2008 Nov 01; 22(21):2926-31. Lee SH, Sterling H, Burlingame A, McCormick F. PMID: 18981471; PMCID: PMC2577792.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansCells
    160. PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Res. 2008 Oct 01; 68(19):8127-36. Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, McCormick F. PMID: 18829572.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansCells
    161. DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight. Nucleic Acids Res. 2008 Aug; 36(14):4689-98. Weisenberger DJ, Trinh BN, Campan M, Sharma S, Long TI, Ananthnarayan S, Liang G, Esteva FJ, Hortobagyi GN, McCormick F, Jones PA, Laird PW. PMID: 18628296; PMCID: PMC2504308.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    162. Absolute quantitative detection of ABL tyrosine kinase domain point mutations in chronic myeloid leukemia using a novel nanofluidic platform and mutation-specific PCR. Leukemia. 2009 Feb; 23(2):396-9. Oehler VG, Qin J, Ramakrishnan R, Facer G, Ananthnarayan S, Cummings C, Deininger M, Shah N, McCormick F, Willis S, Daridon A, Unger M, Radich JP. PMID: 18615105; PMCID: PMC3655797.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    163. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. Oncogene. 2008 Sep 11; 27(40):5303-14. Kitagawa M, Aonuma M, Lee SH, Fukutake S, McCormick F. PMID: 18521084.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    164. An analysis of the rotator interval in patients with anterior, posterior, and multidirectional shoulder instability. Arthroscopy. 2008 Aug; 24(8):921-9. Provencher MT, Dewing CB, Bell SJ, McCormick F, Solomon DJ, Rooney TB, Stanley M. PMID: 18657741.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    165. Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007. Am J Med Genet A. 2008 May 01; 146A(9):1205-17. Rauen KA, Hefner E, Carrillo K, Taylor J, Messier L, Aoki Y, Gripp KW, Matsubara Y, Proud VK, Hammond P, Allanson JE, Delrue MA, Axelrad ME, Lin AE, Doyle DA, Kerr B, Carey JC, McCormick F, Silva AJ, Kieran MW, Hinek A, Nguyen TT, Schoyer L. PMID: 18412122.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    166. Combinatorial patterns of somatic gene mutations in cancer. FASEB J. 2008 Aug; 22(8):2605-22. Yeang CH, McCormick F, Levine A. PMID: 18434431.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCells
    167. Skp2 suppresses p53-dependent apoptosis by inhibiting p300. Mol Cell. 2008 Feb 01; 29(2):217-31. Kitagawa M, Lee SH, McCormick F. PMID: 18243116.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    168. An analysis of capsular area in patients with anterior, posterior, and multidirectional shoulder instability. Am J Sports Med. 2008 Mar; 36(3):515-22. Dewing CB, McCormick F, Bell SJ, Solomon DJ, Stanley M, Rooney TB, Provencher MT. PMID: 18216272.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    169. Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy. PLoS One. 2007 Dec 05; 2(12):e1279. Estep AL, Palmer C, McCormick F, Rauen KA. PMID: 18060073; PMCID: PMC2093994.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    170. Polycystic kidneys: a cautionary story. Br J Radiol. 2007 Dec; 80(960):e305-9. Currie RJ, Freeman SJ, McCormick F, McGonigle RJ. PMID: 18065639.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    171. Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options. Hum Mol Genet. 2008 Feb 01; 17(3):419-30. Senawong T, Phuchareon J, Ohara O, McCormick F, Rauen KA, Tetsu O. PMID: 17981815.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    172. Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst. 2007 Sep 19; 99(18):1410-4. Jiang H, Gomez-Manzano C, Aoki H, Alonso MM, Kondo S, McCormick F, Xu J, Kondo Y, Bekele BN, Colman H, Lang FF, Fueyo J. PMID: 17848677.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    173. Success and failure on the ras pathway. Cancer Biol Ther. 2007 Oct; 6(10):1654-9. McCormick F. PMID: 18245956.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    174. Critical role for arginine methylation in adenovirus-infected cells. J Virol. 2007 Dec; 81(23):13209-17. Iacovides DC, O'Shea CC, Oses-Prieto J, Burlingame A, McCormick F. PMID: 17686851; PMCID: PMC2169124.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    175. Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways. J Mol Med (Berl). 2007 Nov; 85(11):1281-9. Ding VW, Lin LP, Chiang AL, McCormick F. PMID: 17593335.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    176. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS One. 2006 Dec 27; 1:e128. Okabe H, Lee SH, Phuchareon J, Albertson DG, McCormick F, Tetsu O. PMID: 17205132; PMCID: PMC1762433.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimalsCells
    177. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 2006 Dec; 10(6):515-27. Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW. PMID: 17157791; PMCID: PMC2730521.
      View in: PubMed   Mentions: 1739     Fields:    Translation:HumansCells
    178. p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins. EMBO J. 2006 Sep 06; 25(17):4008-19. Lee SH, McCormick F. PMID: 16932749; PMCID: PMC1560370.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    179. Oncolytic adenoviruses as antiglioma agents. Expert Rev Anticancer Ther. 2006 May; 6(5):697-708. Jiang H, McCormick F, Lang FF, Gomez-Manzano C, Fueyo J. PMID: 16759161.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    180. A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Mol Cell. 2006 Apr 21; 22(2):217-30. Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F. PMID: 16630891.
      View in: PubMed   Mentions: 111     Fields:    Translation:HumansCells
    181. Ras ubiquitination: coupling spatial sorting and signal transmission. Cancer Cell. 2006 Apr; 9(4):243-4. Rodriguez-Viciana P, McCormick F. PMID: 16616329.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    182. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. Science. 2006 Mar 03; 311(5765):1287-90. Rodriguez-Viciana P, Tetsu O, Tidyman WE, Estep AL, Conger BA, Cruz MS, McCormick F, Rauen KA. PMID: 16439621.
      View in: PubMed   Mentions: 212     Fields:    Translation:HumansCells
    183. Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan. Clin Cancer Res. 2006 Jan 15; 12(2):556-62. Gomez-Manzano C, Alonso MM, Yung WK, McCormick F, Curiel DT, Lang FF, Jiang H, Bekele BN, Zhou X, Alemany R, Fueyo J. PMID: 16428500.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    184. Wnt-1 signal as a potential cancer therapeutic target. Drug News Perspect. 2006 Jan-Feb; 19(1):27-31. You L, Kim J, He B, Xu Z, McCormick F, Jablons DM. PMID: 16550254.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    185. Characterization of interactions between ras family GTPases and their effectors. Methods Enzymol. 2006; 407:187-94. Rodriguez-Viciana P, McCormick F. PMID: 16757324.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    186. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Cancer Res. 2005 Dec 01; 65(23):10669-73. Oda K, Stokoe D, Taketani Y, McCormick F. PMID: 16322209.
      View in: PubMed   Mentions: 170     Fields:    Translation:HumansCells
    187. Future prospects for oncolytic therapy. Oncogene. 2005 Nov 21; 24(52):7817-9. McCormick F. PMID: 16299540.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    188. Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis. Oncogene. 2005 Aug 11; 24(34):5396-400. Mazieres J, You L, He B, Xu Z, Lee AY, Mikami I, McCormick F, Jablons DM. PMID: 16007226.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    189. Effects of Onyx-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU/leucovorin. Cancer Gene Ther. 2005 Aug; 12(8):673-81. Reid TR, Freeman S, Post L, McCormick F, Sze DY. PMID: 15803147.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCellsCTClinical Trials
    190. A conditional feedback loop regulates Ras activity through EphA2. Cancer Cell. 2005 Aug; 8(2):111-8. Macrae M, Neve RM, Rodriguez-Viciana P, Haqq C, Yeh J, Chen C, Gray JW, McCormick F. PMID: 16098464.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    191. Adenovirus overrides cellular checkpoints for protein translation. Cell Cycle. 2005 Jul; 4(7):883-8. O'Shea CC, Choi S, McCormick F, Stokoe D. PMID: 15970698.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    192. Killing time for cancer cells. Nat Rev Cancer. 2005 07; 5(7):573-80. Klein S, McCormick F, Levitzki A. PMID: 15965492.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    193. Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy. Cancer Cell. 2005 Jul; 8(1):61-74. O'Shea CC, Soria C, Bagus B, McCormick F. PMID: 16023599.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    194. Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. Oncogene. 2005 Apr 21; 24(18):3054-8. He B, Reguart N, You L, Mazieres J, Xu Z, Lee AY, Mikami I, McCormick F, Jablons DM. PMID: 15735684.
      View in: PubMed   Mentions: 99     Fields:    Translation:Humans
    195. Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication. EMBO J. 2005 Mar 23; 24(6):1211-21. O'Shea C, Klupsch K, Choi S, Bagus B, Soria C, Shen J, McCormick F, Stokoe D. PMID: 15775987; PMCID: PMC556401.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansCells
    196. RalGDS comes of age. Cancer Cell. 2005 Mar; 7(3):205-6. Rodriguez-Viciana P, McCormick F. PMID: 15766656.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    197. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. Cancer Res. 2005 Feb 01; 65(3):743-8. He B, Lee AY, Dadfarmay S, You L, Xu Z, Reguart N, Mazieres J, Mikami I, McCormick F, Jablons DM. PMID: 15705870.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    198. Cancer targets in the Ras pathway. Cold Spring Harb Symp Quant Biol. 2005; 70:461-7. Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F. PMID: 16869784.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    199. Downregulation of Skp2 and p27/Kip1 synergistically induces apoptosis in T98G glioblastoma cells. J Mol Med (Berl). 2005 Apr; 83(4):296-307. Lee SH, McCormick F. PMID: 15605273.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    200. Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity. Cancer Cell. 2004 Dec; 6(6):611-23. O'Shea CC, Johnson L, Bagus B, Choi S, Nicholas C, Shen A, Boyle L, Pandey K, Soria C, Kunich J, Shen Y, Habets G, Ginzinger D, McCormick F. PMID: 15607965.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansCells
    201. Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells. J Biol Chem. 2005 Jan 21; 280(3):2012-9. Brandts CH, Bilanges B, Hare G, McCormick F, Stokoe D. PMID: 15542603.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    202. Activation of the hedgehog pathway in advanced prostate cancer. Mol Cancer. 2004 Oct 13; 3:29. Sheng T, Li C, Zhang X, Chi S, He N, Chen K, McCormick F, Gatalica Z, Xie J. PMID: 15482598; PMCID: PMC524523.
      View in: PubMed   Mentions: 143     Fields:    Translation:HumansCells
    203. Cloning and characterization of the promoter of human Wnt inhibitory factor-1. Biochem Biophys Res Commun. 2004 Oct 08; 323(1):229-34. Reguart N, He B, Xu Z, You L, Lee AY, Mazieres J, Mikami I, Batra S, Rosell R, McCormick F, Jablons DM. PMID: 15351726.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    204. Role for PP2A in ARF signaling to p53. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14063-6. Moule MG, Collins CH, McCormick F, Fried M. PMID: 15383668; PMCID: PMC521121.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    205. Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma. Oncogene. 2004 Aug 26; 23(39):6672-6. Lee AY, He B, You L, Dadfarmay S, Xu Z, Mazieres J, Mikami I, McCormick F, Jablons DM. PMID: 15221014.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    206. Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells. Oncogene. 2004 Aug 12; 23(36):6170-4. You L, He B, Xu Z, Uematsu K, Mazieres J, Mikami I, Reguart N, Moody TW, Kitajewski J, McCormick F, Jablons DM. PMID: 15208662.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansCells
    207. An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth. Cancer Res. 2004 Aug 01; 64(15):5385-9. You L, He B, Xu Z, Uematsu K, Mazieres J, Fujii N, Mikami I, Reguart N, McIntosh JK, Kashani-Sabet M, McCormick F, Jablons DM. PMID: 15289346.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    208. Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Res. 2004 Jul 15; 64(14):4717-20. Mazieres J, He B, You L, Xu Z, Lee AY, Mikami I, Reguart N, Rosell R, McCormick F, Jablons DM. PMID: 15256437.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansCells
    209. Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol. 2004 Jun; 24(11):4943-54. Rodriguez-Viciana P, Sabatier C, McCormick F. PMID: 15143186; PMCID: PMC416418.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansCells
    210. Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells. Cancer Res. 2004 May 15; 64(10):3474-8. You L, He B, Uematsu K, Xu Z, Mazieres J, Lee A, McCormick F, Jablons DM. PMID: 15150100.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    211. Cancer: survival pathways meet their end. Nature. 2004 Mar 18; 428(6980):267-9. McCormick F. PMID: 15029179.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    212. Future directions: oncolytic viruses. Clin Lung Cancer. 2004 Jan; 5(4):226-30. You L, He B, Xu Z, McCormick F, Jablons DM. PMID: 14967074.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    213. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia. 2004 Jan-Feb; 6(1):7-14. He B, You L, Uematsu K, Xu Z, Lee AY, Matsangou M, McCormick F, Jablons DM. PMID: 15068666; PMCID: PMC1508626.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    214. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 2004 Jan 01; 18(1):99-115. Timmerman LA, Grego-Bessa J, Raya A, Bertrán E, Pérez-Pomares JM, Díez J, Aranda S, Palomo S, McCormick F, Izpisúa-Belmonte JC, de la Pompa JL. PMID: 14701881; PMCID: PMC314285.
      View in: PubMed   Mentions: 437     Fields:    Translation:AnimalsCells
    215. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14133-8. He B, You L, Uematsu K, Zang K, Xu Z, Lee AY, Costello JF, McCormick F, Jablons DM. PMID: 14617776; PMCID: PMC283558.
      View in: PubMed   Mentions: 163     Fields:    Translation:HumansCells
    216. Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression. Oncogene. 2003 Oct 16; 22(46):7218-21. Uematsu K, He B, You L, Xu Z, McCormick F, Jablons DM. PMID: 14562050.
      View in: PubMed   Mentions: 133     Fields:    Translation:Humans
    217. Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. Cancer Res. 2003 Aug 01; 63(15):4547-51. Uematsu K, Kanazawa S, You L, He B, Xu Z, Li K, Peterlin BM, McCormick F, Jablons DM. PMID: 12907630.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    218. Chromosome aberrations in solid tumors. Nat Genet. 2003 Aug; 34(4):369-76. Albertson DG, Collins C, McCormick F, Gray JW. PMID: 12923544.
      View in: PubMed   Mentions: 299     Fields:    Translation:HumansCells
    219. Cancer-specific viruses and the development of ONYX-015. Cancer Biol Ther. 2003 Jul-Aug; 2(4 Suppl 1):S157-60. McCormick F. PMID: 14508094.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    220. Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells. Cancer Res. 2003 May 01; 63(9):2088-95. Anders M, Christian C, McMahon M, McCormick F, Korn WM. PMID: 12727824.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    221. Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q. Anticancer Res. 2003 May-Jun; 23(3B):2281-9. Jensen RH, Tiirikainen M, You L, Ginzinger D, He B, Uematsu K, Xu Z, Treseler P, McCormick F, Jablons DM. PMID: 12894504.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    222. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell. 2003 Mar; 3(3):233-45. Tetsu O, McCormick F. PMID: 12676582.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansCells
    223. Cloning and characterization of a functional promoter of the human SOCS-3 gene. Biochem Biophys Res Commun. 2003 Feb 07; 301(2):386-91. He B, You L, Uematsu K, Matsangou M, Xu Z, He M, McCormick F, Jablons DM. PMID: 12565872.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    224. Phosphorylation of p16INK4A correlates with Cdk4 association. J Biol Chem. 2003 Feb 28; 278(9):6619-22. Gump J, Stokoe D, McCormick F. PMID: 12529334.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    225. A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14ARF and p16INK4A) in human mesothelioma cells. Anticancer Res. 2003 Jan-Feb; 23(1A):33-8. Yang CT, You L, Lin YC, Lin CL, Mccormick F, Jablons DM. PMID: 12680192.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    226. The RB and p53 pathways in cancer. Cancer Cell. 2002 Aug; 2(2):103-12. Sherr CJ, McCormick F. PMID: 12204530.
      View in: PubMed   Mentions: 596     Fields:    Translation:HumansCells
    227. Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma: potential relevance to gene therapy. Cancer Res. 2002 Jul 01; 62(13):3812-8. Rauen KA, Sudilovsky D, Le JL, Chew KL, Hann B, Weinberg V, Schmitt LD, McCormick F. PMID: 12097294.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    228. MDMX inhibits the p300/CBP-mediated acetylation of p53. DNA Cell Biol. 2002 Jul; 21(7):519-25. Sabbatini P, McCormick F. PMID: 12162806.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    229. Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides. Mol Cancer Ther. 2002 Jul; 1(9):687-94. Xia C, Xu Z, Yuan X, Uematsu K, You L, Li K, Li L, McCormick F, Jablons DM. PMID: 12479365.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    230. Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents. Cancer Cell. 2002 May; 1(4):325-37. Johnson L, Shen A, Boyle L, Kunich J, Pandey K, Lemmon M, Hermiston T, Giedlin M, McCormick F, Fattaey A. PMID: 12086848.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    231. Replication-selective viruses for cancer therapy. J Mol Med (Berl). 2002 Mar; 80(3):163-75. Biederer C, Ries S, Brandts CH, McCormick F. PMID: 11894142.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    232. Cancer gene therapy: fringe or cutting edge? Nat Rev Cancer. 2001 Nov; 1(2):130-41. McCormick F. PMID: 11905804.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    233. p14(ARF) modulates the cytolytic effect of ONYX-015 in mesothelioma cells with wild-type p53. Cancer Res. 2001 Aug 15; 61(16):5959-63. Yang CT, You L, Uematsu K, Yeh CC, McCormick F, Jablons DM. PMID: 11507034.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    234. Method for screening ecdysone-inducible stable cell lines. Biotechniques. 2001 Aug; 31(2):414-8. Wakita K, McCormick F, Tetsu O. PMID: 11515378.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    235. A role of PDGFRalpha in basal cell carcinoma proliferation. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9255-9. Xie J, Aszterbaum M, Zhang X, Bonifas JM, Zachary C, Epstein E, McCormick F. PMID: 11481486; PMCID: PMC55407.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    236. New-age drug meets resistance. Nature. 2001 Jul 19; 412(6844):281-2. McCormick F. PMID: 11460142.
      View in: PubMed   Mentions: 7     Fields:    
    237. Selective targeting to the hyperactive beta-catenin/T-cell factor pathway in colon cancer cells. Cancer Res. 2001 Jun 01; 61(11):4445-9. Chen RH, McCormick F. PMID: 11389074.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    238. Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells. Oncogene. 2001 May 17; 20(22):2826-35. Yount GL, Afshar G, Ries S, Korn M, Shalev N, Basila D, McCormick F, Haas-Kogan DA. PMID: 11420694.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    239. ErbB receptors and Ras: upstream, downstream? Cancer J. 2001 May-Jun; 7(3):178-80. Park JW, McCormick F. PMID: 11419025.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    240. A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics. Cancer Res. 2001 Feb 01; 61(3):854-8. Wakita K, Tetsu O, McCormick F. PMID: 11221869.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    241. ONYX-015 selectivity and the p14ARF pathway. Oncogene. 2000 Dec 27; 19(56):6670-2. McCormick F. PMID: 11426653.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    242. Small-molecule inhibitors of cell signaling. Curr Opin Biotechnol. 2000 Dec; 11(6):593-7. McCormick F. PMID: 11102795.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    243. Interactions between adenovirus proteins and the p53 pathway: the development of ONYX-015. Semin Cancer Biol. 2000 Dec; 10(6):453-9. McCormick F. PMID: 11170867.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    244. Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. J Biol Chem. 2000 Oct 20; 275(42):32475-81. Ding VW, Chen RH, McCormick F. PMID: 10913153.
      View in: PubMed   Mentions: 173     Fields:    Translation:HumansAnimalsCells
    245. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell. 2000 Oct 13; 103(2):321-30. Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F. PMID: 11057904.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    246. Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015). Nat Med. 2000 Oct; 6(10):1128-33. Ries SJ, Brandts CH, Chung AS, Biederer CH, Hann BC, Lipner EM, McCormick F, Korn WM. PMID: 11017144.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    247. The basic helix-loop-helix transcription factors myogenin and Id2 mediate specific induction of caveolin-3 gene expression during embryonic development. J Biol Chem. 2000 Aug 25; 275(34):26245-51. Biederer CH, Ries SJ, Moser M, Florio M, Israel MA, McCormick F, Buettner R. PMID: 10835421.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    248. Regulation of Tiam1 nucleotide exchange activity by pleckstrin domain binding ligands. J Biol Chem. 2000 Aug 18; 275(33):25751-9. Crompton AM, Foley LH, Wood A, Roscoe W, Stokoe D, McCormick F, Symons M, Bollag G. PMID: 10835422.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    249. Wnt signaling to beta-catenin involves two interactive components. Glycogen synthase kinase-3beta inhibition and activation of protein kinase C. J Biol Chem. 2000 Jun 09; 275(23):17894-9. Chen RH, Ding WV, McCormick F. PMID: 10749878.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    250. Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells. J Natl Cancer Inst. 2000 Apr 19; 92(8):636-41. Yang CT, You L, Yeh CC, Chang JW, Zhang F, McCormick F, Jablons DM. PMID: 10772681.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    251. Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling. Mol Cell. 2000 Jan; 5(1):13-25. Tominaga T, Sahai E, Chardin P, McCormick F, Courtneidge SA, Alberts AS. PMID: 10678165.
      View in: PubMed   Mentions: 139     Fields:    Translation:AnimalsCells
    252. Signalling networks that cause cancer. Trends Cell Biol. 1999 Dec; 9(12):M53-6. McCormick F. PMID: 10611683.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    253. Expression of the c-erbB-3/HER-3 and c-erbB-4/HER-4 growth factor receptors and their ligands, neuregulin-1 alpha, neuregulin-1 beta, and betacellulin, in normal endometrium and endometrial cancer. Clin Cancer Res. 1999 Oct; 5(10):2877-83. Srinivasan R, Benton E, McCormick F, Thomas H, Gullick WJ. PMID: 10537356.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    254. Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis. J Biol Chem. 1999 Aug 20; 274(34):24263-9. Sabbatini P, McCormick F. PMID: 10446202.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    255. Cancer therapy based on p53. Cancer J Sci Am. 1999 May-Jun; 5(3):139-44. McCormick F. PMID: 10367167.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    256. Brefeldin A: the advantage of being uncompetitive. Cell. 1999 Apr 16; 97(2):153-5. Chardin P, McCormick F. PMID: 10219235.
      View in: PubMed   Mentions: 156     Fields:    Translation:AnimalsCells
    257. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999 Apr 01; 398(6726):422-6. Tetsu O, McCormick F. PMID: 10201372.
      View in: PubMed   Mentions: 1301     Fields:    Translation:HumansCells
    258. A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene. 1999 Jan 21; 18(3):833-6. Lam CW, Xie J, To KF, Ng HK, Lee KC, Yuen NW, Lim PL, Chan LY, Tong SF, McCormick F. PMID: 9989836.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    259. ONYX-015: clinical data are encouraging. Nat Med. 1998 Dec; 4(12):1341-2. Kirn D, Hermiston T, McCormick F. PMID: 9846551.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    260. Going for the GAP. Curr Biol. 1998 Sep 24; 8(19):R673-4. McCormick F. PMID: 9768349.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    261. Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene. 1998 Jul 23; 17(3):313-25. Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D, McCormick F, Feng J, Tsichlis P. PMID: 9690513.
      View in: PubMed   Mentions: 210     Fields:    Translation:AnimalsCells
    262. Signal transduction. Why Ras needs Rho. Nature. 1998 Jul 16; 394(6690):220-1. McCormick F. PMID: 9685153.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    263. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science. 1998 Jan 30; 279(5351):710-4. Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT. PMID: 9445477.
      View in: PubMed   Mentions: 320     Fields:    Translation:HumansAnimalsCells
    264. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science. 1997 Jul 25; 277(5325):567-70. Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT. PMID: 9228007.
      View in: PubMed   Mentions: 358     Fields:    Translation:HumansAnimalsCells
    265. The superfamily of Ras-related GTPases. Jpn J Cancer Res. 1997 Jul; 88(7):inside front cover. McCormick F. PMID: 9310130.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    266. ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat Med. 1997 Jun; 3(6):639-45. Heise C, Sampson-Johannes A, Williams A, McCormick F, Von Hoff DD, Kirn DH. PMID: 9176490.
      View in: PubMed   Mentions: 222     Fields:    Translation:HumansCells
    267. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Mol Cell Biol. 1997 Jun; 17(6):3449-58. Qiu RG, Abo A, McCormick F, Symons M. PMID: 9154844; PMCID: PMC232198.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    268. Regulation of mitogen-activated protein kinase phosphatase-1 expression by extracellular signal-related kinase-dependent and Ca2+-dependent signal pathways in Rat-1 cells. J Biol Chem. 1997 May 16; 272(20):13309-19. Cook SJ, Beltman J, Cadwallader KA, McMahon M, McCormick F. PMID: 9148952.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    269. The role of p53 in virally associated tumors. Trends Microbiol. 1997 May; 5(5):181-2. McCormick F, Wood DA. PMID: 9160505.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    270. Activation of c-Raf-1 by Ras and Src through different mechanisms: activation in vivo and in vitro. EMBO J. 1997 May 01; 16(9):2384-96. Stokoe D, McCormick F. PMID: 9171352; PMCID: PMC1169839.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    271. Signal transduction from multiple Ras effectors. Curr Opin Genet Dev. 1997 Feb; 7(1):75-9. Katz ME, McCormick F. PMID: 9024640.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    272. Differential regulation of extracellular signal-regulated protein kinase 1 and Jun N-terminal kinase 1 by Ca2+ and protein kinase C in endothelin-stimulated Rat-1 cells. Biochem J. 1997 Feb 01; 321 ( Pt 3):795-804. Cadwallader K, Beltman J, McCormick F, Cook S. PMID: 9032468; PMCID: PMC1218137.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    273. Biochemical characterization of a novel KRAS insertion mutation from a human leukemia. J Biol Chem. 1996 Dec 20; 271(51):32491-4. Bollag G, Adler F, elMasry N, McCabe PC, Conner E, Thompson P, McCormick F, Shannon K. PMID: 8955068.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    274. Replicating viruses as selective cancer therapeutics. Mol Med Today. 1996 Dec; 2(12):519-27. Kirn DH, McCormick F. PMID: 9015793.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    275. Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells. Biochem J. 1996 Nov 15; 320 ( Pt 1):237-45. Cook SJ, McCormick F. PMID: 8947493; PMCID: PMC1217923.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    276. The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase. J Biol Chem. 1996 Oct 25; 271(43):27018-24. Beltman J, McCormick F, Cook SJ. PMID: 8900190.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    277. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science. 1996 Oct 18; 274(5286):373-6. Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M, Ng L, Nye JA, Sampson-Johannes A, Fattaey A, McCormick F. PMID: 8832876.
      View in: PubMed   Mentions: 414     Fields:    Translation:HumansAnimalsCells
    278. The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascades. Oncogene. 1996 Sep 19; 13(6):1323-33. O'Hagan RC, Tozer RG, Symons M, McCormick F, Hassell JA. PMID: 8808707.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    279. Altered transforming growth factor signaling in epithelial cells when ras activation is blocked. J Biol Chem. 1996 Sep 13; 271(37):22368-75. Hartsough MT, Frey RS, Zipfel PA, Buard A, Cook SJ, McCormick F, Mulder KM. PMID: 8798398.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    280. New molecular targets for cancer therapy. Sci Am. 1996 Sep; 275(3):144-9. Oliff A, Gibbs JB, McCormick F. PMID: 8701284.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    281. Interactions between Ras proteins and their effectors. Curr Opin Biotechnol. 1996 Aug; 7(4):449-56. McCormick F, Wittinghofer A. PMID: 8768906.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    282. Ras biology in atomic detail. Nat Struct Biol. 1996 Aug; 3(8):653-5. McCormick F. PMID: 8756317.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    283. Insulin-induced tyrosine phosphorylation of a M(r) 70,000 protein revealed by association with the Src homology 2 (SH2) and SH3 domains of p120GAP and Grb2. Cell Growth Differ. 1996 Apr; 7(4):543-50. Medema JP, Pronk GJ, de Vries-Smits AM, Clark R, McCormick F, Bos JL. PMID: 9052995.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    284. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell. 1996 Mar 08; 84(5):723-34. Symons M, Derry JM, Karlak B, Jiang S, Lemahieu V, Mccormick F, Francke U, Abo A. PMID: 8625410.
      View in: PubMed   Mentions: 227     Fields:    Translation:HumansAnimalsCells
    285. Regulation of epidermal growth factor receptor signaling by phosphorylation of the ras exchange factor hSOS1. J Biol Chem. 1996 Mar 08; 271(10):5871-7. Porfiri E, McCormick F. PMID: 8621459.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    286. Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells. Nat Genet. 1996 Feb; 12(2):144-8. Bollag G, Clapp DW, Shih S, Adler F, Zhang YY, Thompson P, Lange BJ, Freedman MH, McCormick F, Jacks T, Shannon K. PMID: 8563751.
      View in: PubMed   Mentions: 191     Fields:    Translation:HumansAnimalsCells
    287. The human p62 cDNA encodes Sam68 and not the RasGAP-associated p62 protein. Cell. 1996 Jan 12; 84(1):23-4. Lock P, Fumagalli S, Polakis P, McCormick F, Courtneidge SA. PMID: 8548822.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    288. A role for Rho in Ras transformation. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11781-5. Qiu RG, Chen J, McCormick F, Symons M. PMID: 8524848; PMCID: PMC40486.
      View in: PubMed   Mentions: 149     Fields:    Translation:AnimalsCells
    289. Ras-related proteins in signal transduction and growth control. Mol Reprod Dev. 1995 Dec; 42(4):500-6. McCormick F. PMID: 8607982.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    290. Bcr and Raf form a complex in vivo via 14-3-3 proteins. EMBO J. 1995 Oct 02; 14(19):4839-48. Braselmann S, McCormick F. PMID: 7588613; PMCID: PMC394581.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    291. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 1995 Sep 01; 14(17):4385. Martin GA, Bollag G, McCormick F, Abo A. PMID: 7556080; PMCID: PMC394523.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    292. Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein. J Biol Chem. 1995 Jul 28; 270(30):17947-52. Bryant SS, Briggs S, Smithgall TE, Martin GA, McCormick F, Chang JH, Parsons SJ, Jove R. PMID: 7629101.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    293. Rac mediates growth factor-induced arachidonic acid release. Cell. 1995 Jun 16; 81(6):849-56. Peppelenbosch MP, Qiu RG, de Vries-Smits AM, Tertoolen LG, de Laat SW, McCormick F, Hall A, Symons MH, Bos JL. PMID: 7781062.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    294. The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue. Nature. 1995 Jun 15; 375(6532):554-60. Nassar N, Horn G, Herrmann C, Scherer A, McCormick F, Wittinghofer A. PMID: 7791872.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    295. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 1995 May 01; 14(9):1970-8. Martin GA, Bollag G, McCormick F, Abo A. PMID: 7744004; PMCID: PMC398296.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    296. An essential role for Rac in Ras transformation. Nature. 1995 Mar 30; 374(6521):457-9. Qiu RG, Chen J, Kirn D, McCormick F, Symons M. PMID: 7700355.
      View in: PubMed   Mentions: 233     Fields:    Translation:AnimalsCells
    297. Ras signaling and NF1. Curr Opin Genet Dev. 1995 Feb; 5(1):51-5. McCormick F. PMID: 7749326.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    298. Signal transduction by Ras-like GTPases: a potential target for anticancer drugs. Gene Expr. 1995; 4(6):345-56. Spaargaren M, Bischoff JR, McCormick F. PMID: 7549466; PMCID: PMC6134362.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    299. Purification of recombinant Ras GTPase-activating proteins. Methods Enzymol. 1995; 255:21-30. Bollag G, McCormick F. PMID: 8524104.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    300. Intrinsic and GTPase-activating protein-stimulated Ras GTPase assays. Methods Enzymol. 1995; 255:161-70. Bollag G, McCormick F. PMID: 8524100.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    301. Raf: the holy grail of Ras biology? Trends Cell Biol. 1994 Oct; 4(10):347-50. McCormick F. PMID: 14731620.
      View in: PubMed   Mentions: 5     Fields:    
    302. Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science. 1994 Sep 16; 265(5179):1713-6. Freed E, Symons M, Macdonald SG, McCormick F, Ruggieri R. PMID: 8085158.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    303. From genetics to chemistry: tumor suppressor genes and drug discovery. Chem Biol. 1994 Sep; 1(1):7-9. McCormick F, Myers P. PMID: 9383365.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    304. Ras blooms on sterile ground. Nature. 1994 Jun 02; 369(6479):361-2. Cook S, McCormick F. PMID: 8196762.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    305. The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner. Biochem J. 1994 Jun 01; 300 ( Pt 2):303-7. Spaargaren M, Martin GA, McCormick F, Fernandez-Sarabia MJ, Bischoff JR. PMID: 8002932; PMCID: PMC1138162.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    306. Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. N Engl J Med. 1994 Mar 03; 330(9):597-601. Shannon KM, O'Connell P, Martin GA, Paderanga D, Olson K, Dinndorf P, McCormick F. PMID: 8302341.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    307. Platelet-derived growth factor-induced p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or phosphatidylinositol-3-kinase. Cell Growth Differ. 1994 Mar; 5(3):341-7. Burgering BM, Freed E, van der Voorn L, McCormick F, Bos JL. PMID: 8018566.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    308. Activators and effectors of ras p21 proteins. Curr Opin Genet Dev. 1994 Feb; 4(1):71-6. McCormick F. PMID: 8193543.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    309. The non-catalytic domain of ras-GAP inhibits transformation induced by G protein coupled receptors. Oncogene. 1994 Feb; 9(2):597-601. Xu N, McCormick F, Gutkind JS. PMID: 8290270.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    310. Raf-1 interferes with Ras and Rap1A effector functions in yeast. Mol Biol Cell. 1994 Feb; 5(2):173-81. Ruggieri R, Macdonald SG, Callow M, McCormick F. PMID: 8019003; PMCID: PMC301023.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    311. Analysis of the tumor suppressor activity of the K-rev-1 gene in human tumor cell lines. Cancer Res. 1994 Jan 15; 54(2):552-9. Sato KY, Polakis PG, Haubruck H, Fasching CL, McCormick F, Stanbridge EJ. PMID: 8275494.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    312. The RAP1GA1 locus for human Rap1-GTPase activating protein 1 maps to chromosome 1p36.1-->p35. Cytogenet Cell Genet. 1994; 66(1):18-21. Weiss J, Rubinfeld B, Polakis PG, McCormick F, Cavenee WK, Arden KC. PMID: 8275700.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    313. Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines. Hum Genet. 1994 Jan; 93(1):27-31. Mitsudomi T, Friedman E, Gejman PV, McCormick F, Gazdar AF. PMID: 8270251.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    314. Proteins of the 14-3-3 family associate with Raf and contribute to its activation. Cold Spring Harb Symp Quant Biol. 1994; 59:187-93. Freed E, McCormick F, Ruggieri R. PMID: 7587069.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    315. Proteins regulating Ras and its relatives. Nature. 1993 Dec 16; 366(6456):643-54. Boguski MS, McCormick F. PMID: 8259209.
      View in: PubMed   Mentions: 457     Fields:    Translation:HumansAnimalsCells
    316. N-RAS gene activation in acute myeloid leukemia: association with expression of interleukin-6. Leukemia. 1993 Dec; 7(12):1948-54. Lübbert M, Oster W, Knopf HP, McCormick F, Mertelsmann R, Herrmann F. PMID: 8255093.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    317. Inhibition by cAMP of Ras-dependent activation of Raf. Science. 1993 Nov 12; 262(5136):1069-72. Cook SJ, McCormick F. PMID: 7694367.
      View in: PubMed   Mentions: 201     Fields:    Translation:AnimalsCells
    318. Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours. Nat Genet. 1993 Nov; 5(3):242-7. Friedman E, Gejman PV, Martin GA, McCormick F. PMID: 8275088.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    319. Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro. Mol Cell Biol. 1993 Nov; 13(11):6615-20. Macdonald SG, Crews CM, Wu L, Driller J, Clark R, Erikson RL, McCormick F. PMID: 8413257; PMCID: PMC364724.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    320. RapV12 antagonizes Ras-dependent activation of ERK1 and ERK2 by LPA and EGF in Rat-1 fibroblasts. EMBO J. 1993 Sep; 12(9):3475-85. Cook SJ, Rubinfeld B, Albert I, McCormick F. PMID: 8253074; PMCID: PMC413624.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    321. Signal transduction. How receptors turn Ras on. Nature. 1993 May 06; 363(6424):15-6. McCormick F. PMID: 8479530.
      View in: PubMed   Mentions: 120     Fields:    Translation:AnimalsCells
    322. Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target. J Biol Chem. 1993 May 05; 268(13):9157-60. Polakis P, McCormick F. PMID: 8486615.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    323. Characterization of full-length neurofibromin: tubulin inhibits Ras GAP activity. EMBO J. 1993 May; 12(5):1923-7. Bollag G, McCormick F, Clark R. PMID: 8491185; PMCID: PMC413413.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    324. Differential regulation of cellular activities by GTPase-activating protein and NF1. Mol Cell Biol. 1993 Apr; 13(4):2497-503. al-Alawi N, Xu G, White R, Clark R, McCormick F, Feramisco JR. PMID: 8455625; PMCID: PMC359570.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    325. Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins. J Immunol. 1993 Jan 15; 150(2):377-86. Gold MR, Crowley MT, Martin GA, McCormick F, DeFranco AL. PMID: 8419471.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    326. The GTPase superfamily. Introduction. Ciba Found Symp. 1993; 176:1-5. McCormick F. PMID: 8299413.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    327. Specific changes of Ras GTPase-activating protein (GAP) and a GAP-associated p62 protein during calcium-induced keratinocyte differentiation. Mol Cell Biol. 1992 Dec; 12(12):5319-28. Filvaroff E, Calautti E, McCormick F, Dotto GP. PMID: 1448067; PMCID: PMC360469.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    328. Interaction between the p21ras GTPase activating protein and the insulin receptor. J Biol Chem. 1992 Nov 25; 267(33):24058-63. Pronk GJ, Medema RH, Burgering BM, Clark R, McCormick F, Bos JL. PMID: 1331107.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    329. Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis. Mol Cell Biol. 1992 Oct; 12(10):4634-42. Rubinfeld B, Crosier WJ, Albert I, Conroy L, Clark R, McCormick F, Polakis P. PMID: 1406653; PMCID: PMC360390.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    330. Functional interaction between p21rap1A and components of the budding pathway in Saccharomyces cerevisiae. Mol Cell Biol. 1992 Sep; 12(9):4084-92. McCabe PC, Haubruck H, Polakis P, McCormick F, Innis MA. PMID: 1508205; PMCID: PMC360304.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    331. GTPase activating proteins. Semin Cancer Biol. 1992 Aug; 3(4):199-208. Bollag G, McCormick F. PMID: 1421164.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    332. GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion. Mol Cell Biol. 1992 Aug; 12(8):3425-30. Medema RH, de Laat WL, Martin GA, McCormick F, Bos JL. PMID: 1321335; PMCID: PMC364591.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    333. Mutational activation of RAS and GSP oncogenes in differentiated thyroid cancer and their biological implications. World J Surg. 1992 Jul-Aug; 16(4):576-81; discussion 581-2. Goretzki PE, Lyons J, Stacy-Phipps S, Rosenau W, Demeure M, Clark OH, McCormick F, Röher HD, Bourne HR. PMID: 1413827.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    334. Phosphorylation of rap1GAP in vivo and by cAMP-dependent kinase and the cell cycle p34cdc2 kinase in vitro. J Biol Chem. 1992 May 25; 267(15):10780-5. Polakis P, Rubinfeld B, McCormick F. PMID: 1587853.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    335. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell. 1992 May 01; 69(3):413-23. Fantl WJ, Escobedo JA, Martin GA, Turck CW, del Rosario M, McCormick F, Williams LT. PMID: 1374684.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    336. Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell. 1992 May 01; 69(3):551-8. Wong G, Müller O, Clark R, Conroy L, Moran MF, Polakis P, McCormick F. PMID: 1374686.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    337. Coupling of ras p21 signalling and GTP hydrolysis by GTPase activating proteins. Philos Trans R Soc Lond B Biol Sci. 1992 Apr 29; 336(1276):43-7; discussion 47-8. McCormick F. PMID: 1351295.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    338. Ras regulation. NF is enough of GAP. Nature. 1992 Apr 23; 356(6371):663-4. Bollag G, McCormick F. PMID: 1570011.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    339. p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets. J Biol Chem. 1992 Mar 15; 267(8):5025-8. Cichowski K, McCormick F, Brugge JS. PMID: 1544885.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    340. Prevalence of N-ras mutations in children with myelodysplastic syndromes and acute myeloid leukemia. Oncogene. 1992 Feb; 7(2):263-8. Lübbert M, Mirro J, Kitchingman G, McCormick F, Mertelsmann R, Herrmann F, Koeffler HP. PMID: 1549347.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    341. Association of a tyrosine kinase activity with GAP complexes in v-src transformed fibroblasts. Oncogene. 1992 Feb; 7(2):389-94. Pronk GJ, Polakis P, Wong G, de Vries-Smits AM, Bos JL, McCormick F. PMID: 1549356.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    342. GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents. Science. 1992 Jan 10; 255(5041):192-4. Martin GA, Yatani A, Clark R, Conroy L, Polakis P, Brown AM, McCormick F. PMID: 1553544.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    343. Interactions between p21ras proteins and their GTPase activating proteins. Cancer Surv. 1992; 12:25-42. Polakis P, McCormick F. PMID: 1386285.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    344. Heterogeneous amino acids in Ras and Rap1A specifying sensitivity to GAP proteins. Science. 1991 Dec 13; 254(5038):1630-4. Zhang K, Papageorge AG, Martin P, Vass WC, Olah Z, Polakis PG, McCormick F, Lowy DR. PMID: 1749934.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    345. Ras p21: effects and regulation. Biochim Biophys Acta. 1991 Dec 10; 1072(2-3):215-29. Haubruck H, McCormick F. PMID: 1751548.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    346. Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. EMBO J. 1991 Nov; 10(11):3215-20. Dominguez I, Marshall MS, Gibbs JB, García de Herreros A, Cornet ME, Graziani G, Diaz-Meco MT, Johansen T, McCormick F, Moscat J. PMID: 1655413; PMCID: PMC453045.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    347. Ras and the awd couple. Nature. 1991 Oct 03; 353(6343):390-1. Ruggieri R, McCormick F. PMID: 1654523.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    348. Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor. Proc Natl Acad Sci U S A. 1991 Jul 01; 88(13):5927-31. Pendergast AM, Muller AJ, Havlik MH, Clark R, McCormick F, Witte ON. PMID: 1712111; PMCID: PMC51991.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    349. A synthetic peptide corresponding to a sequence in the GTPase activating protein inhibits p21ras stimulation and promotes guanine nucleotide exchange. Int J Pept Protein Res. 1991 Jul; 38(1):47-53. Rubinfeld B, Wong G, Bekesi E, Wood A, Heimer E, McCormick F, Polakis P. PMID: 1938104.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    350. Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. Cell. 1991 Jun 14; 65(6):1033-42. Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F, Polakis P. PMID: 1904317.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    351. Differential regulation of rasGAP and neurofibromatosis gene product activities. Nature. 1991 Jun 13; 351(6327):576-9. Bollag G, McCormick F. PMID: 1904555.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    352. GTP-binding proteins as oncogenes in human tumors. Environ Health Perspect. 1991 Jun; 93:17-8. McCormick F. PMID: 1773789; PMCID: PMC1568037.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    353. Insulin stimulation of gene expression mediated by p21ras activation. EMBO J. 1991 May; 10(5):1103-9. Burgering BM, Medema RH, Maassen JA, van de Wetering ML, van der Eb AJ, McCormick F, Bos JL. PMID: 2022184; PMCID: PMC452763.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    354. Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids. Science. 1991 Apr 26; 252(5005):576-9. Han JW, McCormick F, Macara IG. PMID: 1902323.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    355. Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Mol Cell Biol. 1991 Apr; 11(4):1804-12. Moran MF, Polakis P, McCormick F, Pawson T, Ellis C. PMID: 2005883; PMCID: PMC359849.
      View in: PubMed   Mentions: 80     Fields:    Translation:AnimalsCells
    356. The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein. Mol Cell Biol. 1991 Mar; 11(3):1523-30. Buss JE, Quilliam LA, Kato K, Casey PJ, Solski PA, Wong G, Clark R, McCormick F, Bokoch GM, Der CJ. PMID: 1899909; PMCID: PMC369437.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    357. The GTPase superfamily: conserved structure and molecular mechanism. Nature. 1991 Jan 10; 349(6305):117-27. Bourne HR, Sanders DA, McCormick F. PMID: 1898771.
      View in: PubMed   Mentions: 978     Fields:    Translation:HumansAnimalsCells
    358. Purification of a plasma membrane-associated GTPase-activating protein specific for rap1/Krev-1 from HL60 cells. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):239-43. Polakis PG, Rubinfeld B, Evans T, McCormick F. PMID: 1846040; PMCID: PMC50785.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    359. Regulators and effectors of ras proteins. Annu Rev Cell Biol. 1991; 7:601-32. Bollag G, McCormick F. PMID: 1667084.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    360. Regulation of ras p21 by GTPase activating proteins. Cold Spring Harb Symp Quant Biol. 1991; 56:237-41. McCormick F, Martin GA, Clark R, Bollag G, Polakis P. PMID: 1668082.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    361. Purification, characterization, and western blot analysis of human GTPase-activating protein from native and recombinant sources. J Biol Chem. 1990 Dec 15; 265(35):21922-8. Halenbeck R, Crosier WJ, Clark R, McCormick F, Koths K. PMID: 2123878.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    362. Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein. J Clin Endocrinol Metab. 1990 Dec; 71(6):1416-20. Landis CA, Harsh G, Lyons J, Davis RL, McCormick F, Bourne HR. PMID: 2121775.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    363. The GTPase superfamily: a conserved switch for diverse cell functions. Nature. 1990 Nov 08; 348(6297):125-32. Bourne HR, Sanders DA, McCormick F. PMID: 2122258.
      View in: PubMed   Mentions: 627     Fields:    Translation:HumansAnimalsCells
    364. Oncogenes in multiple myeloma: point mutation of N-ras. Oncogene. 1990 Nov; 5(11):1659-63. Paquette RL, Berenson J, Lichtenstein A, McCormick F, Koeffler HP. PMID: 2267133.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    365. Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. Mol Cell Biol. 1990 Nov; 10(11):5977-82. Munemitsu S, Innis MA, Clark R, McCormick F, Ullrich A, Polakis P. PMID: 2122236; PMCID: PMC361395.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    366. The world according to GAP. Oncogene. 1990 Sep; 5(9):1281-3. McCormick F. PMID: 1699195.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    367. Suppression of c-ras transformation by GTPase-activating protein. Nature. 1990 Aug 23; 346(6286):754-6. Zhang K, DeClue JE, Vass WC, Papageorge AG, McCormick F, Lowy DR. PMID: 2201922.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    368. Inhibition of GTPase activating protein stimulation of Ras-p21 GTPase by the Krev-1 gene product. Science. 1990 Jul 13; 249(4965):169-71. Frech M, John J, Pizon V, Chardin P, Tavitian A, Clark R, McCormick F, Wittinghofer A. PMID: 2164710.
      View in: PubMed   Mentions: 63     Fields:    Translation:Cells
    369. Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins. Mol Cell Biol. 1990 Jun; 10(6):2901-8. Quilliam LA, Der CJ, Clark R, O'Rourke EC, Zhang K, McCormick F, Bokoch GM. PMID: 2160589; PMCID: PMC360652.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    370. ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels. Cell. 1990 Jun 01; 61(5):769-76. Yatani A, Okabe K, Polakis P, Halenbeck R, McCormick F, Brown AM. PMID: 2188736.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    371. PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell. 1990 Apr 06; 61(1):125-33. Kaplan DR, Morrison DK, Wong G, McCormick F, Williams LT. PMID: 2156626.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    372. GTP binding and growth control. Curr Opin Cell Biol. 1990 Apr; 2(2):181-4. McCormick F. PMID: 2141992.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    373. Retrospective analysis of ras gene activation in myeloid leukemic cells. Oncogene. 1990 Apr; 5(4):583-7. Lübbert M, Jonas D, Miller CW, Herrmann F, Mertelsmann R, McCormick F, Koeffler HP. PMID: 2183160.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    374. N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis. Blood. 1990 Mar 01; 75(5):1163-9. Lübbert M, Mirro J, Miller CW, Kahan J, Isaac G, Kitchingman G, Mertelsmann R, Herrmann F, McCormick F, Koeffler HP. PMID: 2407301.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    375. RAS mutations in patients following cytotoxic therapy for lymphoma. Oncogene. 1990 Mar; 5(3):411-6. Carter G, Hughes DC, Clark RE, McCormick F, Jacobs A, Whittaker JA, Padua RA. PMID: 2179819.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    376. Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases. Nature. 1990 Jan 25; 343(6256):377-81. Ellis C, Moran M, McCormick F, Pawson T. PMID: 1689011.
      View in: PubMed   Mentions: 211     Fields:    Translation:AnimalsCells
    377. GAP as ras effector or negative regulator? Mol Carcinog. 1990; 3(4):185-7. McCormick F. PMID: 2206281.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    378. Genetic analysis of mammalian GAP expressed in yeast. Cell. 1989 Nov 17; 59(4):681-6. Ballester R, Michaeli T, Ferguson K, Xu HP, McCormick F, Wigler M. PMID: 2684416.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    379. Production of and responsiveness to transforming growth factor-beta in normal and oncogene-transformed human mammary epithelial cells. Cancer Res. 1989 Nov 15; 49(22):6269-74. Valverius EM, Walker-Jones D, Bates SE, Stampfer MR, Clark R, McCormick F, Dickson RB, Lippman ME. PMID: 2553252.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    380. Gasp: not just another oncogene. Nature. 1989 Aug 31; 340(6236):678-9. McCormick F. PMID: 2505083.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    381. Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogene-transformed mammary epithelial cells. Cancer Res. 1989 Aug 01; 49(15):4258-63. Sommers CL, Walker-Jones D, Heckford SE, Worland P, Valverius E, Clark R, McCormick F, Stampfer M, Abularach S, Gelmann EP. PMID: 2472876.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    382. Human bladder and colon carcinomas contain activated ras p21. Specific detection of twelfth codon mutants. Cancer. 1989 Jun 01; 63(11):2177-81. Meyers FJ, Gumerlock PH, Kokoris SP, deVere White RW, McCormick F. PMID: 2655864.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    383. Identification of resonances from an oncogenic activating locus of human N-RAS-encoded p21 protein using isotope-edited NMR. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):817-20. Burk SC, Papastavros MZ, McCormick F, Redfield AG. PMID: 2644645; PMCID: PMC286568.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    384. ras GTPase activating protein: signal transmitter and signal terminator. Cell. 1989 Jan 13; 56(1):5-8. McCormick F. PMID: 2535967.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    385. Analysis of RAS oncogene mutations in human lymphoid malignancies. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9268-72. Neri A, Knowles DM, Greco A, McCormick F, Dalla-Favera R. PMID: 3057505; PMCID: PMC282720.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    386. Transformation of human mammary epithelial cells by oncogenic retroviruses. Cancer Res. 1988 Aug 15; 48(16):4689-94. Clark R, Stampfer MR, Milley R, O'Rourke E, Walen KH, Kriegler M, Kopplin J, McCormick F. PMID: 3293776.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    387. RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation. Leukemia. 1988 Aug; 2(8):503-10. Padua RA, Carter G, Hughes D, Gow J, Farr C, Oscier D, McCormick F, Jacobs A. PMID: 3166076.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    388. Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain. Science. 1988 Apr 22; 240(4851):518-21. Adari H, Lowy DR, Willumsen BM, Der CJ, McCormick F. PMID: 2833817.
      View in: PubMed   Mentions: 164     Fields:    Translation:AnimalsCells
    389. Functional properties of proteins coded by three human alpha-interferon genes and a pseudogene. Cancer Res. 1988 Apr 01; 48(7):1763-70. Creasey AA, Vitt CR, Herst C, O'Rourke E, Doyle L, Innis MA, McCabe PC, McCormick F, Milley R, Lin LS, et al. PMID: 2964896.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    390. Interaction of ras p21 proteins with GTPase activating protein. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:849-54. McCormick F, Adari H, Trahey M, Halenbeck R, Koths K, Martin GA, Crosier WJ, Watt K, Rubinfeld B, Wong G. PMID: 2855502.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    391. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science. 1987 Oct 23; 238(4826):542-5. Trahey M, McCormick F. PMID: 2821624.
      View in: PubMed   Mentions: 319     Fields:    Translation:AnimalsCells
    392. Biochemical and biological properties of the human N-ras p21 protein. Mol Cell Biol. 1987 Jan; 7(1):541-4. Trahey M, Milley RJ, Cole GE, Innis M, Paterson H, Marshall CJ, Hall A, McCormick F. PMID: 3550423; PMCID: PMC365100.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    393. Inhibition of cell surface ruffling and fluid-phase pinocytosis by microinjection of anti-ras antibodies into living cells. J Cell Physiol Suppl. 1987; Suppl 5:69-73. Bar-Sagi D, McCormick F, Milley RJ, Feramisco JR. PMID: 3316255.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    394. Detection of activated Mr 21,000 protein, the product of ras oncogenes, using antibodies with specificity for amino acid 12. Cancer Res. 1986 Dec; 46(12 Pt 1):6029-33. Wong G, Arnheim N, Clark R, McCabe P, Innis M, Aldwin L, Nitecki D, McCormick F. PMID: 3490906.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    395. Procedures for expression, modification, and analysis of human fibroblast interferon (IFN-beta) genes in heterologous cells. Methods Enzymol. 1986; 119:397-403. Innis MA, McCormick F. PMID: 3531770.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    396. Genetic and biochemical analysis of ras p21 structure. Symp Fundam Cancer Res. 1986; 39:137-42. McCormick F, Levenson C, Cole G, Innis M, Clark R. PMID: 3321304.
      View in: PubMed   Mentions: 1  Translation:Cells
    397. Antibodies specific for amino acid 12 of the ras oncogene product inhibit GTP binding. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5280-4. Clark R, Wong G, Arnheim N, Nitecki D, McCormick F. PMID: 3927300; PMCID: PMC390551.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    398. Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein. Nature. 1985 Apr 18-24; 314(6012):639-42. Feramisco JR, Clark R, Wong G, Arnheim N, Milley R, McCormick F. PMID: 2581140.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    399. Inhibition of protein synthesis stimulates the transcription of human beta-interferon genes in Chinese hamster ovary cells. Proc Natl Acad Sci U S A. 1984 Jul; 81(13):3964-8. Ringold GM, Dieckmann B, Vannice JL, Trahey M, McCormick F. PMID: 6330726; PMCID: PMC345348.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    400. Inducible expression of amplified human beta interferon genes in CHO cells. Mol Cell Biol. 1984 Jan; 4(1):166-72. McCormick F, Trahey M, Innis M, Dieckmann B, Ringold G. PMID: 6700582; PMCID: PMC368671.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    401. SV40 T antigen binds specifically to a cellular 53 K protein in vitro. Nature. 1981 Jul 02; 292(5818):63-5. McCormick F, Clark R, Harlow E, Tjian R. PMID: 6268984.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    402. Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells. J Virol. 1980 Apr; 34(1):213-24. McCormick F, Harlow E. PMID: 6246255; PMCID: PMC288687.
      View in: PubMed   Mentions: 99     Fields:    Translation:AnimalsCells
    403. T antigens of SV40-transformed cells. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:171-8. McCormick F, Chaudry F, Harvey R, Smith R, Rigby PW, Paucha E, Smith AE. PMID: 6253131.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    404. Kinetics of polyamine synthesis and turnover in mouse fibroblasts. Biochem J. 1978 Aug 15; 174(2):427-34. McCormick F. PMID: 708395; PMCID: PMC1185931.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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