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Anthony Defranco, PhD

Title(s)Professor, Microbiology and Immunology
SchoolSchool of Medicine
Phone415-476-5488
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    Organ-specific autoimmunity resulting from two genetic defects in tolerance
    NIH/NIAID R01AI138479Mar 1, 2018 - Feb 28, 2023
    Role: Principal Investigator
    B cell TLRs and germinal centers
    NIH/NIAID R21AI117378Jul 1, 2015 - Jun 30, 2017
    Role: Principal Investigator
    BCR regulation of antibody responses
    NIH/NIAID R56AI108684Aug 1, 2014 - Jul 31, 2015
    Role: Principal Investigator
    The role of Apobec3 enzymes in regulation of marginal zone B cells
    NIH/NIAID R21AI107101Jul 1, 2013 - Jun 30, 2015
    Role: Co-Principal Investigator
    Innate immune regulation of inflammation and adaptive immunity
    NIH/NIAID P01AI078869Jul 15, 2008 - Jun 30, 2013
    Role: Principal Investigator
    Cell Type-Specific Roles of TLR Signaling In Immune Responses
    NIH/NIAID R01AI072058Jan 1, 2008 - Dec 31, 2013
    Role: Principal Investigator
    SELECTIVE GENE ABLATION IN MATURE B LYMPHOCYTES
    NIH/FIC F06TW002281Dec 4, 1998
    Role: Principal Investigator
    TRANSFUSION BIOLOGY AND MEDICINE
    NIH/NHLBI P50HL054476Feb 1, 1996 - Dec 31, 2006
    Role: Co-Investigator
    Cytoskeleton and Signal Transduction in Host Defense
    NIH/NIAID R01AI035811May 1, 1994 - Jan 31, 2010
    Role: Principal Investigator
    Immune Tolerance and Autoimmunity
    NIH/NIAID P01AI035297Sep 30, 1993 - Jul 31, 2012
    Role: Co-Investigator
    LPS-INDUCED SIGNALING IN MACROPHAGES
    NIH/NIAID R01AI033442Aug 1, 1993 - Jul 31, 2001
    Role: Principal Investigator
    Molecular and Cellular Immunology
    NIH/NIAID T32AI007334Sep 1, 1988 - Jul 31, 2024
    Role: Principal Investigator
    REGULATION OF IMMUNE SYSTEM CELLS BY BACTERIAL PRODUCTS
    NIH/NIAID R01AI023864Apr 1, 1987 - Mar 31, 1990
    Role: Principal Investigator
    Regulation of B lymphocyte proliferation by antigen
    NIH/NIAID R56AI020038Jan 1, 1984 - Jun 30, 2014
    Role: Principal Investigator
    Regulation of B Lymphocyte Proliferation by Antigen
    NIH/NIAID R01AI020038Jan 1, 1984 - Nov 30, 2012
    Role: Principal Investigator
    REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    NIH/NIAID R37AI020038Jan 1, 1984 - Mar 31, 2005
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wigton EJ, DeFranco AL, Ansel KM. Antigen Complexed with a TLR9 Agonist Bolsters c-Myc and mTORC1 Activity in Germinal Center B Lymphocytes. Immunohorizons. 2019 08 19; 3(8):389-401. PMID: 31427364.
      View in: PubMed
    2. Faggioni M, Baber U, Chandrasekhar J, Sartori S, Claessen BE, Rao SV, Vogel B, Effron MB, Poddar K, Farhan S, Kini A, Weintraub W, Toma C, Sorrentino S, Weiss S, Snyder C, Muhlestein JB, Kapadia S, Keller S, Strauss C, Aquino M, Baker B, Defranco A, Pocock S, Henry T, Mehran R. Use of prasugrel vs clopidogrel and outcomes in patients with and without diabetes mellitus presenting with acute coronary syndrome undergoing percutaneous coronary intervention. Int J Cardiol. 2019 Jan 15; 275:31-35. PMID: 30391067.
      View in: PubMed
    3. DeFranco AL. Multilayer Control of B Cell Activation by the B Cell Antigen Receptor: Following Themes Initiated With Bill Paul. Front Immunol. 2018; 9:739. PMID: 29740430.
      View in: PubMed
    4. Tian M, Hua Z, Hong S, Zhang Z, Liu C, Lin L, Chen J, Zhang W, Zhou X, Zhang F, DeFranco AL, Hou B. B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle. J Immunol. 2018 02 01; 200(3):937-948. PMID: 29282308.
      View in: PubMed
    5. Costa S, Marini O, Bevilacqua D, DeFranco AL, Hou B, Lonardi S, Vermi W, Rodegher P, Panato A, Tagliaro F, Lowell CA, Cassatella MA, Girolomoni G, Scapini P. Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells. J Leukoc Biol. 2017 09; 102(3):791-803. PMID: 28642279.
      View in: PubMed
    6. DeFranco AL. Innate B cells cleave to the marginal zone. Nat Immunol. 2017 02 15; 18(3):248-250. PMID: 28198824.
      View in: PubMed
    7. Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS One. 2016; 11(12):e0167693. PMID: 27977701.
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    8. Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL. LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity. J Clin Invest. 2016 10 03; 126(10):3758-3771. PMID: 27571405.
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    9. DeFranco AL. Germinal centers and autoimmune disease in humans and mice. Immunol Cell Biol. 2016 11; 94(10):918-924. PMID: 27562062.
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    10. Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M. MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase. PLoS Pathog. 2016 08; 12(8):e1005787. PMID: 27542117.
      View in: PubMed
    11. DeFranco AL. The germinal center antibody response in health and disease. F1000Res. 2016; 5. PMID: 27303636.
      View in: PubMed
    12. Anthony L. DeFranco. Signaling Pathways Downstream of TLRs and IL-1 Family Receptors. Encyclopedia of Immunobiology. 2016 Jan 1; 106-114.
      View in: Publisher Site
    13. Anthony L DeFranco. B Lymphocytes: Receptors. eLS. 2015 Nov 16; 1-15.
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    14. Beck-Engeser GB, Winkelmann R, Wheeler ML, Shansab M, Yu P, Wünsche S, Walchhütter A, Metzner M, Vettermann C, Eilat D, DeFranco A, Jäck HM, Wabl M. APOBEC3 enzymes restrict marginal zone B cells. Eur J Immunol. 2015 Mar; 45(3):695-704. PMID: 25501566.
      View in: PubMed
    15. Rookhuizen DC, DeFranco AL. Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):E3224-33. PMID: 25053813.
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    16. Minjia Yu, Hao Zhou, Junjie Zhao, Nengming Xiao, Sanjoy Roychowdhury, David Schmitt, Bingqing Hu, Richard M. Ransohoff, Clifford V. Harding, Amy G. Hise, Stanley L. Hazen, Anthony L. DeFranco, Paul L. Fox, Richard E. Morton, Paul E. Dicorleto, Maria Febbraio, Laura E. Nagy, Jonathan D. Smith, Jian-an Wang, Xiaoxia Li. MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. Journal of Experimental Medicine. 2014 May 5; 211(5):1003-1003.
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    17. Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D, Hu B, Ransohoff RM, Harding CV, Hise AG, Hazen SL, DeFranco AL, Fox PL, Morton RE, Dicorleto PE, Febbraio M, Nagy LE, Smith JD, Wang JA, Li X. MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. J Exp Med. 2014 May 05; 211(5):887-907. PMID: 24752299.
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    18. Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol. 2014 Feb 01; 192(3):875-85. PMID: 24379120.
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    19. Lamagna C, Hu Y, DeFranco AL, Lowell CA. B cell-specific loss of Lyn kinase leads to autoimmunity. J Immunol. 2014 Feb 01; 192(3):919-28. PMID: 24376269.
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    20. Wheeler ML, Dong MB, Brink R, Zhong XP, DeFranco AL. Diacylglycerol kinase ? limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. Sci Signal. 2013 Oct 15; 6(297):ra91. PMID: 24129701.
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    21. Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3311-20. PMID: 23940344.
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    22. Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, Wu GD, Choi Y. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity. 2013 Jun 27; 38(6):1211-22. PMID: 23791643.
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    23. Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A. Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol. 2013 Jul 15; 191(2):535-9. PMID: 23785118.
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    24. Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F. Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-?-dependent elimination of Paneth cells. Nat Immunol. 2013 Feb; 14(2):136-42. PMID: 23263554.
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    25. Kim CC, Nelson CS, Wilson EB, Hou B, DeFranco AL, DeRisi JL. Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control. PLoS One. 2012; 7(10):e48126. PMID: 23144737.
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    26. Wheeler ML, Defranco AL. Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation. J Immunol. 2012 Nov 01; 189(9):4405-16. PMID: 23024271.
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    27. DeFranco AL, Rookhuizen DC, Hou B. Contribution of Toll-like receptor signaling to germinal center antibody responses. Immunol Rev. 2012 May; 247(1):64-72. PMID: 22500832.
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    28. Thompson AL, Johnson BT, Sempowski GD, Gunn MD, Hou B, DeFranco AL, Staats HF. Maximal adjuvant activity of nasally delivered IL-1a requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production. J Immunol. 2012 Mar 15; 188(6):2834-46. PMID: 22345651.
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    29. Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F. B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity. 2012 Feb 24; 36(2):228-38. PMID: 22306056.
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    30. Shahaf G, Gross AJ, Sternberg-Simon M, Kaplan D, DeFranco AL, Mehr R. Lyn deficiency affects B-cell maturation as well as survival. Eur J Immunol. 2012 Feb; 42(2):511-21. PMID: 22057631.
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    31. Gross AJ, Proekt I, DeFranco AL. Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells. Eur J Immunol. 2011 Dec; 41(12):3645-55. PMID: 21928281.
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    32. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol. 2011 Oct 23; 12(12):1184-93. PMID: 22019834.
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    33. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32. PMID: 21911371.
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    34. Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV. Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8743-8. PMID: 21555560.
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    35. Hou B, Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L, Lee LM, Coffman RL, Bachmann MF, DeFranco AL. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity. 2011 Mar 25; 34(3):375-84. PMID: 21353603.
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    36. Rahman AH, Zhang R, Blosser CD, Hou B, Defranco AL, Maltzman JS, Wherry EJ, Turka LA. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood. 2011 Mar 17; 117(11):3123-30. PMID: 21233312.
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    37. S Vaishnava, K Severson, K Ruhn, J Benjamin, X Yu, B Hu, M Yamamoto, A Defranco, E Wakeland, L Hooper. The antibacterial C-type lectin RegIIIgamma maintains spatial segregation between microbiota and host in the intestine. Inflammatory Bowel Diseases. 2011 Jan 1; 17(suppl_1):s2-s3.
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    38. Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F. Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):278-83. PMID: 21173242.
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    39. Scapini P, Hu Y, Chu CL, Migone TS, Defranco AL, Cassatella MA, Lowell CA. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med. 2010 Aug 02; 207(8):1757-73. PMID: 20624892.
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    40. Anthony L. DeFranco. The B-Cell Antigen Receptor. Topley \u0026 Wilson\u0027s Microbiology and Microbial Infections. 2010 Mar 15.
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    41. Mamchak AA, Thien CB, Dagger SA, Lyandres J, Jiang S, Langdon WY, DeFranco AL. Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice. Eur J Immunol. 2010 Feb; 40(2):539-47. PMID: 19904769.
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    42. Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol. 2009 May 01; 182(9):5382-92. PMID: 19380785.
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    43. DeFranco AL. "Dangerous crystals". Immunity. 2008 Nov 14; 29(5):670-1. PMID: 19006690.
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    44. Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol. 2008 Oct 15; 181(8):5374-85. PMID: 18832694.
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    45. Hou B, Reizis B, DeFranco AL. Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity. 2008 Aug 15; 29(2):272-82. PMID: 18656388.
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    46. Gupta N, DeFranco AL. Lipid rafts and B cell signaling. Semin Cell Dev Biol. 2007 Oct; 18(5):616-26. PMID: 17719248.
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    47. Gupta N, Wollscheid B, Watts JD, Scheer B, Aebersold R, DeFranco AL. Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics. Nat Immunol. 2006 Jun; 7(6):625-33. PMID: 16648854.
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    48. Nishiya T, Kajita E, Miwa S, Defranco AL. TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J Biol Chem. 2005 Nov 04; 280(44):37107-17. PMID: 16105838.
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    49. Tian MT, Gonzalez G, Scheer B, DeFranco AL. Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood. 2005 Sep 15; 106(6):2105-12. PMID: 15878976.
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    50. Nishiya T, DeFranco AL. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem. 2004 Apr 30; 279(18):19008-17. PMID: 14976215.
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    51. Gupta N, DeFranco AL. Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell. 2003 Feb; 14(2):432-44. PMID: 12589045.
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    52. Yu CC, Mamchak AA, DeFranco AL. Signaling mutations and autoimmunity. Curr Dir Autoimmun. 2003; 6:61-88. PMID: 12408047.
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    53. Ohashi PS, DeFranco AL. Making and breaking tolerance. Curr Opin Immunol. 2002 Dec; 14(6):744-59. PMID: 12413525.
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    54. DeFranco AL. Vav and the B cell signalosome. Nat Immunol. 2001 Jun; 2(6):482-4. PMID: 11376331.
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    55. Tian MT, Chou CH, DeFranco AL. Apoptosis induced by the antigen receptor and Fas in a variant of the immature B cell line WEHI-231 and in splenic immature B cells. Int Immunol. 2001 Apr; 13(4):581-92. PMID: 11282997.
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    56. Richards JD, Davé SH, Chou CH, Mamchak AA, DeFranco AL. Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen. J Immunol. 2001 Mar 15; 166(6):3855-64. PMID: 11238629.
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    57. Yu CC, Yen TS, Lowell CA, DeFranco AL. Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn. Curr Biol. 2001 Jan 09; 11(1):34-8. PMID: 11166177.
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    58. DeFranco AL. B-cell activation 2000. Immunol Rev. 2000 Aug; 176:5-9. PMID: 11043763.
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    59. Fujimoto M, Fujimoto Y, Poe JC, Jansen PJ, Lowell CA, DeFranco AL, Tedder TF. CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. Immunity. 2000 Jul; 13(1):47-57. PMID: 10933394.
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    60. Weinstein SL, Finn AJ, Davé SH, Meng F, Lowell CA, Sanghera JS, DeFranco AL. Phosphatidylinositol 3-kinase and mTOR mediate lipopolysaccharide-stimulated nitric oxide production in macrophages via interferon-beta. J Leukoc Biol. 2000 Mar; 67(3):405-14. PMID: 10733102.
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    61. Fitzer-Attas CJ, Lowry M, Crowley MT, Finn AJ, Meng F, DeFranco AL, Lowell CA. Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J Exp Med. 2000 Feb 21; 191(4):669-82. PMID: 10684859.
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    62. Mary Lee MacKichan, Anthony L. DeFranco. Cell signaling and cytokine induction by lipopolysaccharide. Novel Cytokine Inhibitors. 2000 Jan 1; 9-42.
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    63. Harmer SL, DeFranco AL. The src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes. J Biol Chem. 1999 Apr 23; 274(17):12183-91. PMID: 10207047.
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    64. MacKichan ML, DeFranco AL. Role of ceramide in lipopolysaccharide (LPS)-induced signaling. LPS increases ceramide rather than acting as a structural homolog. J Biol Chem. 1999 Jan 15; 274(3):1767-75. PMID: 9880559.
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    65. DeFranco AL, Chan VW, Lowell CA. Positive and negative roles of the tyrosine kinase Lyn in B cell function. Semin Immunol. 1998 Aug; 10(4):299-307. PMID: 9695186.
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    66. Chan VW, Lowell CA, DeFranco AL. Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol. 1998 May 07; 8(10):545-53. PMID: 9601638.
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    67. DeFranco AL, Crowley MT, Finn A, Hambleton J, Weinstein SL. The role of tyrosine kinases and map kinases in LPS-induced signaling. Prog Clin Biol Res. 1998; 397:119-36. PMID: 9575553.
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    68. Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med. 1997 Oct 06; 186(7):1027-39. PMID: 9314552.
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    69. Harmer SL, DeFranco AL. Shc contains two Grb2 binding sites needed for efficient formation of complexes with SOS in B lymphocytes. Mol Cell Biol. 1997 Jul; 17(7):4087-95. PMID: 9199344.
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    70. Chan VW, Meng F, Soriano P, DeFranco AL, Lowell CA. Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997 Jul; 7(1):69-81. PMID: 9252121.
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    71. DeFranco AL. The complexity of signaling pathways activated by the BCR. Curr Opin Immunol. 1997 Jun; 9(3):296-308. PMID: 9203421.
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    72. Roth PE, DeFranco AL. Receptor tails unlock developmental checkpoints for B lymphocytes. Science. 1996 Jun 21; 272(5269):1752-4. PMID: 8650572.
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    73. DeFranco AL. The two-headed antigen. B-cell co-receptors. Curr Biol. 1996 May 01; 6(5):548-50. PMID: 8805272.
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    74. Hambleton J, Weinstein SL, Lem L, DeFranco AL. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci U S A. 1996 Apr 02; 93(7):2774-8. PMID: 8610116.
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    75. Richards JD, Gold MR, Hourihane SL, DeFranco AL, Matsuuchi L. Reconstitution of B cell antigen receptor-induced signaling events in a nonlymphoid cell line by expressing the Syk protein-tyrosine kinase. J Biol Chem. 1996 Mar 15; 271(11):6458-66. PMID: 8626447.
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    76. Horne MC, Roth PE, DeFranco AL. Assembly of the truncated immunoglobulin heavy chain D mu into antigen receptor-like complexes in pre-B cells but not in B cells. Immunity. 1996 Feb; 4(2):145-58. PMID: 8624805.
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    77. Crowley MT, Harmer SL, DeFranco AL. Activation-induced association of a 145-kDa tyrosine-phosphorylated protein with Shc and Syk in B lymphocytes and macrophages. J Biol Chem. 1996 Jan 12; 271(2):1145-52. PMID: 8557643.
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    78. DeFranco AL, Richards JD, Blum JH, Stevens TL, Law DA, Chan VW, Datta SK, Foy SP, Hourihane SL, Gold MR. Signal transduction by the B-cell antigen receptor. Ann N Y Acad Sci. 1995 Sep 07; 766:195-201. PMID: 7486656.
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    79. Hambleton J, McMahon M, DeFranco AL. Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events. J Exp Med. 1995 Jul 01; 182(1):147-54. PMID: 7790814.
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    80. DeFranco AL, Law DA. Tyrosine phosphatases and the antibody response. Science. 1995 Apr 14; 268(5208):263-4. PMID: 7716518.
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    81. Roth PE, DeFranco AL. Lymphocyte development. Intrinsic checkpoints for lineage progression. Curr Biol. 1995 Apr 01; 5(4):349-52. PMID: 7627545.
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    82. DeFranco AL. Transmembrane signaling by antigen receptors of B and T lymphocytes. Curr Opin Cell Biol. 1995 Apr; 7(2):163-75. PMID: 7612267.
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    83. DeFranco AL, Hambleton J, McMahon M, Weinstein SL. Examination of the role of MAP kinase in the response of macrophages to lipopolysaccharide. Prog Clin Biol Res. 1995; 392:407-20. PMID: 8524948.
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    84. Anthony L. DeFranco, Robert L. Coffman. Lymphocyte activation and effector functions Editorial overview. Current Opinion in Immunology. 1995 Jan 1; 7(3):303-305.
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    85. Anthony L. DeFranco, Jonathan H. Blum, Tracy L. Stevens, Debbie A. Law, Vivien W.-F. Chan, Shaun P. Foy, Sandip K. Datta, Linda Matsuuchi. Structure and Function of the B-Cell Antigen Receptor. Lymphocyte Activation. 1994 Aug 23; 59:156-172.
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    86. DeFranco AL. Signaling pathways activated by protein tyrosine phosphorylation in lymphocytes. Curr Opin Immunol. 1994 Jun; 6(3):364-71. PMID: 7917103.
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    87. Stevens TL, Blum JH, Foy SP, Matsuuchi L, DeFranco AL. A mutation of the mu transmembrane that disrupts endoplasmic reticulum retention. Effects on association with accessory proteins and signal transduction. J Immunol. 1994 May 01; 152(9):4397-406. PMID: 8157960.
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    88. Gold MR, DeFranco AL. Biochemistry of B lymphocyte activation. Adv Immunol. 1994; 55:221-95. PMID: 8304234.
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    89. DeFranco AL, Blum JH, Stevens TL, Law DA, Chan VW, Foy SP, Datta SK, Matsuuchi L. Structure and function of the B-cell antigen receptor. Chem Immunol. 1994; 59:156-72. PMID: 7945925.
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    90. DeFranco AL, Mittelstadt PR, Blum JH, Stevens TL, Law DA, Chan VW, Foy SP, Datta SK, Matsuuchi L. Mechanism of B cell antigen receptor function: transmembrane signaling and triggering of apoptosis. Adv Exp Med Biol. 1994; 365:9-22. PMID: 7887317.
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    91. Blum JH, Stevens TL, DeFranco AL. Role of the mu immunoglobulin heavy chain transmembrane and cytoplasmic domains in B cell antigen receptor expression and signal transduction. J Biol Chem. 1993 Dec 25; 268(36):27236-45. PMID: 8262964.
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    117. Page DM, DeFranco AL. Antigen receptor-induced cell cycle arrest in WEHI-231 B lymphoma cells depends on the duration of signaling before the G1 phase restriction point. Mol Cell Biol. 1990 Jun; 10(6):3003-12. PMID: 2342467.
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    120. Anthony L. DeFranco, Michael R. Gold. Signal Transduction via the B Cell Antigen Receptor: Involvement of a G Protein and Regulation of Signaling. Mechanisms of Lymphocyte Activation and Immune Regulation II. 1989 Jan 1; 101-112.
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    127. Fahey KA, DeFranco AL. Cross-linking membrane IgM induces production of inositol trisphosphate and inositol tetrakisphosphate in WEHI-231 B lymphoma cells. J Immunol. 1987 Jun 01; 138(11):3935-42. PMID: 3035017.
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    128. Gold MR, DeFranco AL. Phorbol esters and dioctanoylglycerol block anti-IgM-stimulated phosphoinositide hydrolysis in the murine B cell lymphoma WEHI-231. J Immunol. 1987 Feb 01; 138(3):868-76. PMID: 3027166.
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    129. DeFranco AL, Gold MR, Jakway JP. B-lymphocyte signal transduction in response to anti-immunoglobulin and bacterial lipopolysaccharide. Immunol Rev. 1987 Feb; 95:161-76. PMID: 3032773.
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    133. Jakway JP, Usinger WR, Gold MR, Mishell RI, DeFranco AL. Growth regulation of the B lymphoma cell line WEHI-231 by anti-immunoglobulin, lipopolysaccharide, and other bacterial products. J Immunol. 1986 Oct 01; 137(7):2225-31. PMID: 3489760.
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    134. LaBaer J, Tsien RY, Fahey KA, DeFranco AL. Stimulation of the antigen receptor on WEHI-231 B lymphoma cells results in a voltage-independent increase in cytoplasmic calcium. J Immunol. 1986 Sep 15; 137(6):1836-44. PMID: 2427581.
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    135. DeFranco AL, Raveche ES, Paul WE. Separate control of B lymphocyte early activation and proliferation in response to anti-IgM antibodies. J Immunol. 1985 Jul; 135(1):87-94. PMID: 3873499.
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    136. Ashwell JD, DeFranco AL, Paul WE, Schwartz RH. Can resting B cells present antigen to T cells? Fed Proc. 1985 May; 44(8):2475-9. PMID: 3886434.
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    137. DeFranco AL, Ashwell JD, Schwartz RH, Paul WE. Polyclonal stimulation of resting B lymphocytes by antigen-specific T lymphocytes. J Exp Med. 1984 Mar 01; 159(3):861-80. PMID: 6199453.
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    140. Raveche ES, Steinberg AD, DeFranco AL, Tjio JH. Cell cycle analysis of lymphocyte activation in normal and autoimmune strains of mice. J Immunol. 1982 Sep; 129(3):1219-26. PMID: 6125541.
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    142. DeFranco AL, Kung JT, Paul WE. Regulation of growth and proliferation in B cell subpopulations. Immunol Rev. 1982; 64:161-82. PMID: 6806172.
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