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Anthony Defranco, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMicrobiology and Immunology
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-476-5488
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    Collapse Research 
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    Organ-specific autoimmunity resulting from two genetic defects in tolerance
    NIH/NIAID R01AI138479Mar 1, 2018 - Feb 28, 2023
    Role: Principal Investigator
    B cell TLRs and germinal centers
    NIH/NIAID R21AI117378Jul 1, 2015 - Jun 30, 2017
    Role: Principal Investigator
    BCR regulation of antibody responses
    NIH/NIAID R56AI108684Aug 1, 2014 - Jul 31, 2015
    Role: Principal Investigator
    The role of Apobec3 enzymes in regulation of marginal zone B cells
    NIH/NIAID R21AI107101Jul 1, 2013 - Jun 30, 2015
    Role: Co-Principal Investigator
    Innate immune regulation of inflammation and adaptive immunity
    NIH/NIAID P01AI078869Jul 15, 2008 - Jun 30, 2013
    Role: Principal Investigator
    Cell Type-Specific Roles of TLR Signaling In Immune Responses
    NIH/NIAID R01AI072058Jan 1, 2008 - Dec 31, 2013
    Role: Principal Investigator
    SELECTIVE GENE ABLATION IN MATURE B LYMPHOCYTES
    NIH/FIC F06TW002281Dec 4, 1998
    Role: Principal Investigator
    TRANSFUSION BIOLOGY AND MEDICINE
    NIH/NHLBI P50HL054476Feb 1, 1996 - Dec 31, 2006
    Role: Co-Investigator
    Cytoskeleton and Signal Transduction in Host Defense
    NIH/NIAID R01AI035811May 1, 1994 - Jan 31, 2010
    Role: Principal Investigator
    Immune Tolerance and Autoimmunity
    NIH/NIAID P01AI035297Sep 30, 1993 - Jul 31, 2012
    Role: Co-Investigator
    LPS-INDUCED SIGNALING IN MACROPHAGES
    NIH/NIAID R01AI033442Aug 1, 1993 - Jul 31, 2001
    Role: Principal Investigator
    Molecular and Cellular Immunology
    NIH/NIAID T32AI007334Sep 1, 1988 - Jul 31, 2019
    Role: Principal Investigator
    REGULATION OF IMMUNE SYSTEM CELLS BY BACTERIAL PRODUCTS
    NIH/NIAID R01AI023864Apr 1, 1987 - Mar 31, 1990
    Role: Principal Investigator
    Regulation of B lymphocyte proliferation by antigen
    NIH/NIAID R56AI020038Jan 1, 1984 - Jun 30, 2014
    Role: Principal Investigator
    Regulation of B Lymphocyte Proliferation by Antigen
    NIH/NIAID R01AI020038Jan 1, 1984 - Nov 30, 2012
    Role: Principal Investigator
    REGULATION OF B LYMPHOCYTE PROLIFERATION BY ANTIGEN
    NIH/NIAID R37AI020038Jan 1, 1984 - Mar 31, 2005
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. DeFranco AL. Multilayer Control of B Cell Activation by the B Cell Antigen Receptor: Following Themes Initiated With Bill Paul. Front Immunol. 2018; 9:739. PMID: 29740430.
      View in: PubMed
    2. Tian M, Hua Z, Hong S, Zhang Z, Liu C, Lin L, Chen J, Zhang W, Zhou X, Zhang F, DeFranco AL, Hou B. B Cell-Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle. J Immunol. 2018 Feb 01; 200(3):937-948. PMID: 29282308.
      View in: PubMed
    3. Costa S, Marini O, Bevilacqua D, DeFranco AL, Hou B, Lonardi S, Vermi W, Rodegher P, Panato A, Tagliaro F, Lowell CA, Cassatella MA, Girolomoni G, Scapini P. Role of MyD88 signaling in the imiquimod-induced mouse model of psoriasis: focus on innate myeloid cells. J Leukoc Biol. 2017 Sep; 102(3):791-803. PMID: 28642279.
      View in: PubMed
    4. DeFranco AL. Innate B cells cleave to the marginal zone. Nat Immunol. 2017 02 15; 18(3):248-250. PMID: 28198824.
      View in: PubMed
    5. Lee LM, Ji M, Sinha M, Dong MB, Ren X, Wang Y, Lowell CA, Ghosh S, Locksley RM, DeFranco AL. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS One. 2016; 11(12):e0167693. PMID: 27977701.
      View in: PubMed
    6. Proekt I, Miller CN, Jeanne M, Fasano KJ, Moon JJ, Lowell CA, Gould DB, Anderson MS, DeFranco AL. LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity. J Clin Invest. 2016 Oct 03; 126(10):3758-3771. PMID: 27571405.
      View in: PubMed
    7. DeFranco AL. Germinal centers and autoimmune disease in humans and mice. Immunol Cell Biol. 2016 11; 94(10):918-924. PMID: 27562062.
      View in: PubMed
    8. Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M. MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the Contraction Phase. PLoS Pathog. 2016 Aug; 12(8):e1005787. PMID: 27542117; PMCID: PMC4991787.
    9. DeFranco AL. The germinal center antibody response in health and disease. F1000Res. 2016; 5. PMID: 27303636; PMCID: PMC4882753.
    10. Beck-Engeser GB, Winkelmann R, Wheeler ML, Shansab M, Yu P, Wünsche S, Walchhütter A, Metzner M, Vettermann C, Eilat D, DeFranco A, Jäck HM, Wabl M. APOBEC3 enzymes restrict marginal zone B cells. Eur J Immunol. 2015 Mar; 45(3):695-704. PMID: 25501566; PMCID: PMC4972502.
    11. Rookhuizen DC, DeFranco AL. Toll-like receptor 9 signaling acts on multiple elements of the germinal center to enhance antibody responses. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):E3224-33. PMID: 25053813; PMCID: PMC4128120.
    12. Yu M, Zhou H, Zhao J, Xiao N, Roychowdhury S, Schmitt D, Hu B, Ransohoff RM, Harding CV, Hise AG, Hazen SL, DeFranco AL, Fox PL, Morton RE, Dicorleto PE, Febbraio M, Nagy LE, Smith JD, Wang JA, Li X. MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. J Exp Med. 2014 May 05; 211(5):887-907. PMID: 24752299; PMCID: PMC4010914.
    13. Hua Z, Gross AJ, Lamagna C, Ramos-Hernández N, Scapini P, Ji M, Shao H, Lowell CA, Hou B, DeFranco AL. Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice. J Immunol. 2014 Feb 01; 192(3):875-85. PMID: 24379120; PMCID: PMC4101002.
    14. Lamagna C, Hu Y, DeFranco AL, Lowell CA. B cell-specific loss of Lyn kinase leads to autoimmunity. J Immunol. 2014 Feb 01; 192(3):919-28. PMID: 24376269; PMCID: PMC3900234.
    15. Wheeler ML, Dong MB, Brink R, Zhong XP, DeFranco AL. Diacylglycerol kinase ? limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. Sci Signal. 2013 Oct 15; 6(297):ra91. PMID: 24129701; PMCID: PMC4108475.
    16. Lamagna C, Scapini P, van Ziffle JA, DeFranco AL, Lowell CA. Hyperactivated MyD88 signaling in dendritic cells, through specific deletion of Lyn kinase, causes severe autoimmunity and inflammation. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3311-20. PMID: 23940344; PMCID: PMC3761623.
    17. Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco A, Wu GD, Choi Y. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity. 2013 Jun 27; 38(6):1211-22. PMID: 23791643; PMCID: PMC3715143.
    18. Callahan JA, Hammer GE, Agelides A, Duong BH, Oshima S, North J, Advincula R, Shifrin N, Truong HA, Paw J, Barrera J, DeFranco A, Rosenblum MD, Malynn BA, Ma A. Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. J Immunol. 2013 Jul 15; 191(2):535-9. PMID: 23785118; PMCID: PMC3702626.
    19. Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco A, Gilpin CJ, Hooper LV, Yarovinsky F. Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-?-dependent elimination of Paneth cells. Nat Immunol. 2013 Feb; 14(2):136-42. PMID: 23263554; PMCID: PMC3552073.
    20. Kim CC, Nelson CS, Wilson EB, Hou B, DeFranco AL, DeRisi JL. Splenic red pulp macrophages produce type I interferons as early sentinels of malaria infection but are dispensable for control. PLoS One. 2012; 7(10):e48126. PMID: 23144737; PMCID: PMC3483282.
    21. Wheeler ML, Defranco A. Prolonged production of reactive oxygen species in response to B cell receptor stimulation promotes B cell activation and proliferation. J Immunol. 2012 Nov 01; 189(9):4405-16. PMID: 23024271; PMCID: PMC3515638.
    22. DeFranco AL, Rookhuizen DC, Hou B. Contribution of Toll-like receptor signaling to germinal center antibody responses. Immunol Rev. 2012 May; 247(1):64-72. PMID: 22500832; PMCID: PMC3334874.
    23. Thompson AL, Johnson BT, Sempowski GD, Gunn MD, Hou B, DeFranco AL, Staats HF. Maximal adjuvant activity of nasally delivered IL-1a requires adjuvant-responsive CD11c(+) cells and does not correlate with adjuvant-induced in vivo cytokine production. J Immunol. 2012 Mar 15; 188(6):2834-46. PMID: 22345651; PMCID: PMC3293937.
    24. Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, DeFranco AL, Yarovinsky F. B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity. 2012 Feb 24; 36(2):228-38. PMID: 22306056; PMCID: PMC3288553.
    25. Shahaf G, Gross AJ, Sternberg-Simon M, Kaplan D, DeFranco AL, Mehr R. Lyn deficiency affects B-cell maturation as well as survival. Eur J Immunol. 2012 Feb; 42(2):511-21. PMID: 22057631; PMCID: PMC3516919.
    26. Gross AJ, Proekt I, DeFranco AL. Elevated BCR signaling and decreased survival of Lyn-deficient transitional and follicular B cells. Eur J Immunol. 2011 Dec; 41(12):3645-55. PMID: 21928281; PMCID: PMC3517141.
    27. Hammer GE, Turer EE, Taylor KE, Fang CJ, Advincula R, Oshima S, Barrera J, Huang EJ, Hou B, Malynn BA, Reizis B, DeFranco A, Criswell LA, Nakamura MC, Ma A. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol. 2011 Oct 23; 12(12):1184-93. PMID: 22019834.
      View in: PubMed
    28. Scapini P, Lamagna C, Hu Y, Lee K, Tang Q, DeFranco AL, Lowell CA. B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):E823-32. PMID: 21911371; PMCID: PMC3193193.
    29. Ismail AS, Severson KM, Vaishnava S, Behrendt CL, Yu X, Benjamin JL, Ruhn KA, Hou B, DeFranco AL, Yarovinsky F, Hooper LV. Gammadelta intraepithelial lymphocytes are essential mediators of host-microbial homeostasis at the intestinal mucosal surface. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8743-8. PMID: 21555560; PMCID: PMC3102410.
    30. Hou B, Saudan P, Ott G, Wheeler ML, Ji M, Kuzmich L, Lee LM, Coffman RL, Bachmann MF, DeFranco AL. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity. 2011 Mar 25; 34(3):375-84. PMID: 21353603; PMCID: PMC3064721.
    31. Rahman AH, Zhang R, Blosser CD, Hou B, Defranco A, Maltzman JS, Wherry EJ, Turka LA. Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88. Blood. 2011 Mar 17; 117(11):3123-30. PMID: 21233312; PMCID: PMC3062314.
    32. Hou B, Benson A, Kuzmich L, DeFranco AL, Yarovinsky F. Critical coordination of innate immune defense against Toxoplasma gondii by dendritic cells responding via their Toll-like receptors. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):278-83. PMID: 21173242; PMCID: PMC3017180.
    33. Scapini P, Hu Y, Chu CL, Migone TS, Defranco A, Cassatella MA, Lowell CA. Myeloid cells, BAFF, and IFN-gamma establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice. J Exp Med. 2010 Aug 02; 207(8):1757-73. PMID: 20624892; PMCID: PMC2916124.
    34. Mamchak AA, Thien CB, Dagger SA, Lyandres J, Jiang S, Langdon WY, DeFranco AL. Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice. Eur J Immunol. 2010 Feb; 40(2):539-47. PMID: 19904769; PMCID: PMC2976765.
    35. Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL. Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance. J Immunol. 2009 May 01; 182(9):5382-92. PMID: 19380785; PMCID: PMC2840041.
    36. DeFranco AL. "Dangerous crystals". Immunity. 2008 Nov 14; 29(5):670-1. PMID: 19006690.
      View in: PubMed
    37. Mamchak AA, Sullivan BM, Hou B, Lee LM, Gilden JK, Krummel MF, Locksley RM, DeFranco AL. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol. 2008 Oct 15; 181(8):5374-85. PMID: 18832694; PMCID: PMC2657555.
    38. Hou B, Reizis B, DeFranco AL. Toll-like receptors activate innate and adaptive immunity by using dendritic cell-intrinsic and -extrinsic mechanisms. Immunity. 2008 Aug 15; 29(2):272-82. PMID: 18656388; PMCID: PMC2847796.
    39. Gupta N, DeFranco AL. Lipid rafts and B cell signaling. Semin Cell Dev Biol. 2007 Oct; 18(5):616-26. PMID: 17719248; PMCID: PMC2169358.
    40. Gupta N, Wollscheid B, Watts JD, Scheer B, Aebersold R, DeFranco AL. Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics. Nat Immunol. 2006 Jun; 7(6):625-33. PMID: 16648854.
      View in: PubMed
    41. Nishiya T, Kajita E, Miwa S, Defranco A. TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements. J Biol Chem. 2005 Nov 04; 280(44):37107-17. PMID: 16105838.
      View in: PubMed
    42. Tian MT, Gonzalez G, Scheer B, DeFranco AL. Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood. 2005 Sep 15; 106(6):2105-12. PMID: 15878976; PMCID: PMC1895143.
    43. Nishiya T, DeFranco AL. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J Biol Chem. 2004 Apr 30; 279(18):19008-17. PMID: 14976215.
      View in: PubMed
    44. Gupta N, DeFranco AL. Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell. 2003 Feb; 14(2):432-44. PMID: 12589045; PMCID: PMC149983.
    45. Yu CC, Mamchak AA, DeFranco AL. Signaling mutations and autoimmunity. Curr Dir Autoimmun. 2003; 6:61-88. PMID: 12408047.
      View in: PubMed
    46. Ohashi PS, DeFranco AL. Making and breaking tolerance. Curr Opin Immunol. 2002 Dec; 14(6):744-59. PMID: 12413525.
      View in: PubMed