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    Aoife O'Donovan, PhD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentPsychiatry
    Address3333 Calif. St,Laurel Heights
    San Francisco CA 94143
    Phone415-476-7748

       Biography 
       Education and Training
      University of California, San FranciscoPostdoctoral StudiesGraduate Division
       Awards and Honors
      Career Development Institute for Psychiatry2014 - 2016Scholar Award
      Society in Science2010 - 2015Branco Weiss Fellowship
      American College of Neuropsychopharmacology2013Travel Award
      Academy of Behavioral Medicine Research2012Neal E. Miller New Investigator Award
      American Psychosomatic Society2008Scholar Award
      Psychoneuroimmunology Research Society2008 - 2011Trainee Award
      Rotary International2007 - 2009Ambassadorial Scholarship
      The Fulbright Program2007 - 2008Fulbright Scholarship
      Psychological Society of Ireland2007Postgraduate Student of the Year
      Newman Scholarship Program2004 - 2007Craig Dobbin Newman Scholarship
      University College Cork1998College Scholar Award

       Overview 
       Overview
      People who experience traumatic or enduring psychological stress are more likely to develop psychiatric disorders and age-related diseases such as cardiovascular, autoimmune and neurodegenerative disorders. Our research is focused on revealing how psychological stress “gets under the skin” and more precisely “into cells” to affect mental and physical health. We aim to identify the psychological and biological factors that account for the adverse effects of psychological stress, and ultimately to drive the development of targeted interventions to reduce such negative effects of stress. To this end, we are currently focused on examining the effects of specific kinds of psychological stress on indices and mechanisms of biological aging including telomere shortening, inflammatory activity and oxidative stress.


       ORNG Applications 
       Websites
       In The News

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Murphy TM, O'Donovan A, Mullins N, O'Farrelly C, McCann A, Malone K. Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes. Psychiatr Genet. 2014 Oct 27.
        View in: PubMed
      2. Rao MN, Chau A, Madden E, Inslicht S, Talbot L, Richards A, O'Donovan A, Ruoff L, Grunfeld C, Neylan TC. Hyperinsulinemic response to oral glucose challenge in individuals with posttraumatic stress disorder. Psychoneuroendocrinology. 2014 Nov; 49:171-81.
        View in: PubMed
      3. O'Donovan A, Cohen BE, Seal KH, Bertenthal D, Margaretten M, Nishimi K, Neylan TC. Elevated Risk for Autoimmune Disorders in Iraq and Afghanistan Veterans with Posttraumatic Stress Disorder. Biol Psychiatry. 2014 Jun 28.
        View in: PubMed
      4. Inslicht SS, Richards A, Madden E, Rao MN, O'Donovan A, Talbot LS, Rucker E, Metzler TJ, Hauger RL, Neylan TC. Sex differences in neurosteroid and hormonal responses to metyrapone in posttraumatic stress disorder. Psychopharmacology (Berl). 2014 Sep; 231(17):3581-95.
        View in: PubMed
      5. Woolley JD, Chuang B, Lam O, Lai W, O'Donovan A, Rankin KP, Mathalon DH, Vinogradov S. Oxytocin administration enhances controlled social cognition in patients with schizophrenia. Psychoneuroendocrinology. 2014 Sep; 47:116-25.
        View in: PubMed
      6. O'Donovan A. Inflammation and depression: unraveling the complex interplay in inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2014 May; 58(5):541-2.
        View in: PubMed
      7. Puterman E, Epel ES, O'Donovan A, Prather AA, Aschbacher K, Dhabhar FS. Anger Is Associated with Increased IL-6 Stress Reactivity in Women, But Only Among Those Low in Social Support. Int J Behav Med. 2013 Dec 20.
        View in: PubMed
      8. Kosnes L, Whelan R, O'Donovan A, McHugh LA. Implicit measurement of positive and negative future thinking as a predictor of depressive symptoms and hopelessness. Conscious Cogn. 2013 Sep; 22(3):898-912.
        View in: PubMed
      9. O'Donovan A, Rush G, Hoatam G, Hughes BM, McCrohan A, Kelleher C, O'Farrelly C, Malone KM. Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder. Depress Anxiety. 2013 Apr; 30(4):307-14.
        View in: PubMed
      10. Aschbacher K, O'Donovan A, Wolkowitz OM, Dhabhar FS, Su Y, Epel E. Good stress, bad stress and oxidative stress: insights from anticipatory cortisol reactivity. Psychoneuroendocrinology. 2013 Sep; 38(9):1698-708.
        View in: PubMed
      11. O'Donovan A, Slavich GM, Epel ES, Neylan TC. Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging. Neurosci Biobehav Rev. 2013 Jan; 37(1):96-108.
        View in: PubMed
      12. Adler N, Pantell MS, O'Donovan A, Blackburn E, Cawthon R, Koster A, Opresko P, Newman A, Harris TB, Epel E. Educational attainment and late life telomere length in the Health, Aging and Body Composition Study. Brain Behav Immun. 2013 Jan; 27(1):15-21.
        View in: PubMed
      13. O'Donovan A, Neylan TC, Metzler T, Cohen BE. Lifetime exposure to traumatic psychological stress is associated with elevated inflammation in the Heart and Soul Study. Brain Behav Immun. 2012 May; 26(4):642-9.
        View in: PubMed
      14. O'Donovan A, Tomiyama AJ, Lin J, Puterman E, Adler NE, Kemeny M, Wolkowitz OM, Blackburn EH, Epel ES. Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere length. Brain Behav Immun. 2012 May; 26(4):573-9.
        View in: PubMed
      15. Tomiyama AJ, O'Donovan A, Lin J, Puterman E, Lazaro A, Chan J, Dhabhar FS, Wolkowitz O, Kirschbaum C, Blackburn E, Epel E. Does cellular aging relate to patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length. Physiol Behav. 2012 Apr 12; 106(1):40-5.
        View in: PubMed
      16. Prather AA, Puterman E, Lin J, O'Donovan A, Krauss J, Tomiyama AJ, Epel ES, Blackburn EH. Shorter leukocyte telomere length in midlife women with poor sleep quality. J Aging Res. 2011; 2011:721390.
        View in: PubMed
      17. Puterman E, O'Donovan A, Adler NE, Tomiyama AJ, Kemeny M, Wolkowitz OM, Epel E. Physical activity moderates effects of stressor-induced rumination on cortisol reactivity. Psychosom Med. 2011 Sep; 73(7):604-11.
        View in: PubMed
      18. O'Donovan A, Pantell MS, Puterman E, Dhabhar FS, Blackburn EH, Yaffe K, Cawthon RM, Opresko PL, Hsueh WC, Satterfield S, Newman AB, Ayonayon HN, Rubin SM, Harris TB, Epel ES. Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition Study. PLoS One. 2011; 6(5):e19687.
        View in: PubMed
      19. O'Donovan A, Epel E, Lin J, Wolkowitz O, Cohen B, Maguen S, Metzler T, Lenoci M, Blackburn E, Neylan TC. Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder. Biol Psychiatry. 2011 Sep 1; 70(5):465-71.
        View in: PubMed
      20. O'Donovan A, Sun B, Cole S, Rempel H, Lenoci M, Pulliam L, Neylan T. Transcriptional control of monocyte gene expression in post-traumatic stress disorder. Dis Markers. 2011; 30(2-3):123-32.
        View in: PubMed
      21. Neylan TC, Sun B, Rempel H, Ross J, Lenoci M, O'Donovan A, Pulliam L. Suppressed monocyte gene expression profile in men versus women with PTSD. Brain Behav Immun. 2011 Mar; 25(3):524-31.
        View in: PubMed
      22. Puterman E, Lin J, Blackburn E, O'Donovan A, Adler N, Epel E. The power of exercise: buffering the effect of chronic stress on telomere length. PLoS One. 2010; 5(5):e10837.
        View in: PubMed
      23. O'Donovan A, Hughes BM, Slavich GM, Lynch L, Cronin MT, O'Farrelly C, Malone KM. Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships. Brain Behav Immun. 2010 Oct; 24(7):1074-7.
        View in: PubMed
      24. Slavich GM, O'Donovan A, Epel ES, Kemeny ME. Black sheep get the blues: a psychobiological model of social rejection and depression. Neurosci Biobehav Rev. 2010 Sep; 35(1):39-45.
        View in: PubMed
      25. O'Donovan A, Lin J, Tillie J, Tillie JM, Dhabhar FS, Wolkowitz OM, Wolkowitz O, Blackburn EH, Blackburn E, Epel ES, Epel E. Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women. Brain Behav Immun. 2009 May; 23(4):446-9.
        View in: PubMed
      26. O'Donovan A, Hughes BM. Access to social support in life and in the laboratory: combined impact on cardiovascular reactivity to stress and state anxiety. J Health Psychol. 2008 Nov; 13(8):1147-56.
        View in: PubMed
      27. O'Loughlin C, Murphy NF, Conlon C, O'Donovan A, Ledwidge M, McDonald K. Quality of life predicts outcome in a heart failure disease management program. Int J Cardiol. 2010 Feb 18; 139(1):60-7.
        View in: PubMed
      28. O'Donovan, A. Hughes, B.M. Factors that moderate the effects of social support on cardiovascular reactivity to stress. Int J Psychol. & Psychol. Therapy. 2008; (8):85-102.
      29. O'Donovan A, Hughes B. Social support and loneliness in college students: effects on pulse pressure reactivity to acute stress. Int J Adolesc Med Health. 2007 Oct-Dec; 19(4):523-8.
        View in: PubMed
      30. O'Donovan, A. Hughes, B.M. Your best interests at heart?. The Psychologist. 2006; (19):216-219.
      31. Dymond S, O'Hora D, Whelan R, O'Donovan A. Citation Analysis of Skinner's Verbal Behavior: 1984-2004. Behav Anal. 2006; 29(1):75-88.
        View in: PubMed
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