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    Diane Barber, PhD

    TitleProfessor
    SchoolUCSF School of Dentistry
    DepartmentCell and Tissue Biology
    Address513 Parnassus Ave
    San Francisco CA 94143
    Phone415-476-3764

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       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Broz ML, Binnewies M, Boldajipour B, Nelson AE, Pollack JL, Erle DJ, Barczak A, Rosenblum MD, Daud A, Barber DL, Amigorena S, Van't Veer LJ, Sperling AI, Wolf DM, Krummel MF. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014 Nov 10; 26(5):638-52.
        View in: PubMed
      2. Grillo-Hill BK, Webb BA, Barber DL. Ratiometric Imaging of pH Probes. Methods Cell Biol. 2014; 123:429-48.
        View in: PubMed
      3. Choi CH, Webb BA, Chimenti MS, Jacobson MP, Barber DL. pH sensing by FAK-His58 regulates focal adhesion remodeling. J Cell Biol. 2013 Sep 16; 202(6):849-59.
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      4. Crevenna AH, Naredi-Rainer N, Schönichen A, Dzubiella J, Barber DL, Lamb DC, Wedlich-Söldner R. Electrostatics control actin filament nucleation and elongation kinetics. J Biol Chem. 2013 Apr 26; 288(17):12102-13.
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      5. Schönichen A, Webb BA, Jacobson MP, Barber DL. Considering protonation as a posttranslational modification regulating protein structure and function. Annu Rev Biophys. 2013; 42:289-314.
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      6. Gillis LC, Berry DM, Minden MD, McGlade CJ, Barber DL. Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia. Leukemia. 2013 Aug; 27(8):1666-76.
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      7. Choi CH, Thomason PA, Zaki M, Insall RH, Barber DL. Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in Dictyostelium. J Biol Chem. 2013 Jan 25; 288(4):2464-74.
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      8. Nunomura W, Denker SP, Barber DL, Takakuwa Y, Gascard P. Characterization of cytoskeletal protein 4.1R interaction with NHE1 (Na(+)/H(+) exchanger isoform 1). Biochem J. 2012 Sep 15; 446(3):427-35.
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      9. Narayanan A, LeClaire LL, Barber DL, Jacobson MP. Phosphorylation of the Arp2 subunit relieves auto-inhibitory interactions for Arp2/3 complex activation. PLoS Comput Biol. 2011 Nov; 7(11):e1002226.
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      10. Haynes J, Srivastava J, Madson N, Wittmann T, Barber DL. Dynamic actin remodeling during epithelial-mesenchymal transition depends on increased moesin expression. Mol Biol Cell. 2011 Dec; 22(24):4750-64.
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      11. Webb BA, Chimenti M, Jacobson MP, Barber DL. Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer. 2011 Sep; 11(9):671-7.
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      12. Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin C, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T. A human MAP kinase interactome. Nat Methods. 2010 Oct; 7(10):801-5.
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      13. Jiménez-Vidal M, Srivastava J, Putney LK, Barber DL. Nuclear-localized calcineurin homologous protein CHP1 interacts with upstream binding factor and inhibits ribosomal RNA synthesis. J Biol Chem. 2010 Nov 19; 285(47):36260-6.
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      14. Choi CH, Patel H, Barber DL. Expression of actin-interacting protein 1 suppresses impaired chemotaxis of Dictyostelium cells lacking the Na+-H+ exchanger NHE1. Mol Biol Cell. 2010 Sep 15; 21(18):3162-70.
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      15. Meima ME, Webb BA, Witkowska HE, Barber DL. The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors. J Biol Chem. 2009 Sep 25; 284(39):26666-75.
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      16. Karydis A, Jimenez-Vidal M, Denker SP, Barber DL. Mislocalized scaffolding by the Na-H exchanger NHE1 dominantly inhibits fibronectin production and TGF-beta activation. Mol Biol Cell. 2009 Apr; 20(8):2327-36.
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      17. Frantz C, Barreiro G, Dominguez L, Chen X, Eddy R, Condeelis J, Kelly MJ, Jacobson MP, Barber DL. Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding. J Cell Biol. 2008 Dec 1; 183(5):865-79.
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      18. Srivastava J, Barreiro G, Groscurth S, Gingras AR, Goult BT, Critchley DR, Kelly MJ, Jacobson MP, Barber DL. Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14436-41.
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      19. LeClaire LL, Baumgartner M, Iwasa JH, Mullins RD, Barber DL. Phosphorylation of the Arp2/3 complex is necessary to nucleate actin filaments. J Cell Biol. 2008 Aug 25; 182(4):647-54.
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      20. Srivastava J, Barber D. Actin co-sedimentation assay; for the analysis of protein binding to F-actin. J Vis Exp. 2008; (13).
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      21. Frantz C, Karydis A, Nalbant P, Hahn KM, Barber DL. Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells. J Cell Biol. 2007 Nov 5; 179(3):403-10.
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      22. Meima ME, Mackley JR, Barber DL. Beyond ion translocation: structural functions of the sodium-hydrogen exchanger isoform-1. Curr Opin Nephrol Hypertens. 2007 Jul; 16(4):365-72.
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      23. Srivastava J, Barber DL, Jacobson MP. Intracellular pH sensors: design principles and functional significance. Physiology (Bethesda). 2007 Feb; 22:30-9.
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      24. Baumgartner M, Sillman AL, Blackwood EM, Srivastava J, Madson N, Schilling JW, Wright JH, Barber DL. The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors. Proc Natl Acad Sci U S A. 2006 Sep 5; 103(36):13391-6.
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      25. Patel H, Barber DL. A developmentally regulated Na-H exchanger in Dictyostelium discoideum is necessary for cell polarity during chemotaxis. J Cell Biol. 2005 Apr 25; 169(2):321-9.
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      26. Baumgartner M, Patel H, Barber DL. Na(+)/H(+) exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes. Am J Physiol Cell Physiol. 2004 Oct; 287(4):C844-50.
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      27. Putney LK, Barber DL. Expression profile of genes regulated by activity of the Na-H exchanger NHE1. BMC Genomics. 2004 Jul 16; 5(1):46.
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      28. Putney LK, Barber DL. Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition. J Biol Chem. 2003 Nov 7; 278(45):44645-9.
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      29. Lin CY, Varma MG, Joubel A, Madabushi S, Lichtarge O, Barber DL. Conserved motifs in somatostatin, D2-dopamine, and alpha 2B-adrenergic receptors for inhibiting the Na-H exchanger, NHE1. J Biol Chem. 2003 Apr 25; 278(17):15128-35.
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      30. Denker SP, Barber DL. Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1. J Cell Biol. 2002 Dec 23; 159(6):1087-96.
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      31. Buchan AM, Lin CY, Choi J, Barber DL. Somatostatin, acting at receptor subtype 1, inhibits Rho activity, the assembly of actin stress fibers, and cell migration. J Biol Chem. 2002 Aug 9; 277(32):28431-8.
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      32. Denker SP, Barber DL. Ion transport proteins anchor and regulate the cytoskeleton. Curr Opin Cell Biol. 2002 Apr; 14(2):214-20.
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      33. Putney LK, Denker SP, Barber DL. The changing face of the Na+/H+ exchanger, NHE1: structure, regulation, and cellular actions. Annu Rev Pharmacol Toxicol. 2002; 42:527-52.
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      34. Nguyen MH, Ho JM, Beattie BK, Barber DL. TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway. J Biol Chem. 2001 Aug 31; 276(35):32704-13.
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      35. Yan W, Nehrke K, Choi J, Barber DL. The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. J Biol Chem. 2001 Aug 17; 276(33):31349-56.
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      36. Zhang MY, Barber DL, Alessi DR, Bell LL, Stine C, Nguyen MH, Beattie BK, Cheung JY, Miller BA. A minimal cytoplasmic subdomain of the erythropoietin receptor mediates p70 S6 kinase phosphorylation. Exp Hematol. 2001 Apr; 29(4):432-40.
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      37. Denker SP, Huang DC, Orlowski J, Furthmayr H, Barber DL. Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. Mol Cell. 2000 Dec; 6(6):1425-36.
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      38. Mason JM, Beattie BK, Liu Q, Dumont DJ, Barber DL. The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor. J Biol Chem. 2000 Feb 11; 275(6):4398-406.
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      39. Denker SP, Yan W, Barber DL. Effect of Rho GTPases on Na-H exchanger in mammalian cells. Methods Enzymol. 2000; 325:334-48.
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      40. Chaudhry FA, Reimer RJ, Krizaj D, Barber D, Storm-Mathisen J, Copenhagen DR, Edwards RH. Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. Cell. 1999 Dec 23; 99(7):769-80.
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      41. Lin X, Sikkink RA, Rusnak F, Barber DL. Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein. J Biol Chem. 1999 Dec 17; 274(51):36125-31.
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      42. Ho JM, Beattie BK, Squire JA, Frank DA, Barber DL. Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling. Blood. 1999 Jun 15; 93(12):4354-64.
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      43. Tominaga T, Ishizaki T, Narumiya S, Barber DL. p160ROCK mediates RhoA activation of Na-H exchange. EMBO J. 1998 Aug 17; 17(16):4712-22.
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      44. Tominaga T, Barber DL. Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading. Mol Biol Cell. 1998 Aug; 9(8):2287-303.
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      45. Boussiotis VA, Freeman GJ, Berezovskaya A, Barber DL, Nadler LM. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science. 1997 Oct 3; 278(5335):124-8.
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      46. Barber DL, Corless CN, Xia K, Roberts TM, D'Andrea AD. Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells. Blood. 1997 Jan 1; 89(1):55-64.
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      47. Lin X, Barber DL. A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12631-6.
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      48. Xia K, Mukhopadhyay NK, Inhorn RC, Barber DL, Rose PE, Lee RS, Narsimhan RP, D'Andrea AD, Griffin JD, Roberts TM. The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11681-6.
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      49. Lin X, Voyno-Yasenetskaya TA, Hooley R, Lin CY, Orlowski J, Barber DL. Galpha12 differentially regulates Na+-H+ exchanger isoforms. J Biol Chem. 1996 Sep 13; 271(37):22604-10.
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      50. Vexler ZS, Symons M, Barber DL. Activation of Na+-H+ exchange is necessary for RhoA-induced stress fiber formation. J Biol Chem. 1996 Sep 13; 271(37):22281-4.
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      51. Hooley R, Yu CY, Symons M, Barber DL. G alpha 13 stimulates Na+-H+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways. J Biol Chem. 1996 Mar 15; 271(11):6152-8.
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      52. Yamashita T, Barber DL, Zhu Y, Wu N, D'Andrea AD. The Fanconi anemia polypeptide FACC is localized to the cytoplasm. Proc Natl Acad Sci U S A. 1994 Jul 5; 91(14):6712-6.
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      53. Hou C, Gilbert RL, Barber DL. Subtype-specific signaling mechanisms of somatostatin receptors SSTR1 and SSTR2. J Biol Chem. 1994 Apr 8; 269(14):10357-62.
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      54. Barber DL, DeMartino JC, Showers MO, D'Andrea AD. A dominant negative erythropoietin (EPO) receptor inhibits EPO-dependent growth and blocks F-gp55-dependent transformation. Mol Cell Biol. 1994 Apr; 14(4):2257-65.
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      55. Voyno-Yasenetskaya T, Conklin BR, Gilbert RL, Hooley R, Bourne HR, Barber DL. G alpha 13 stimulates Na-H exchange. J Biol Chem. 1994 Feb 18; 269(7):4721-4.
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      56. Barber DL, Ganz MB. Guanine nucleotides regulate beta-adrenergic activation of Na-H exchange independently of receptor coupling to Gs. J Biol Chem. 1992 Oct 15; 267(29):20607-12.
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      57. Barber DL, Ganz MB, Bongiorno PB, Strader CD. Mutant constructs of the beta-adrenergic receptor that are uncoupled from adenylyl cyclase retain functional activation of Na-H exchange. Mol Pharmacol. 1992 Jun; 41(6):1056-60.
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      58. Barber DL, Cacace AM, Raucci DT, Ganz MB. Fatty acids stereospecifically stimulate neurotensin release and increase [Ca2+]i in enteric endocrine cells. Am J Physiol. 1991 Sep; 261(3 Pt 1):G497-503.
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      59. Barber DL. Mechanisms of receptor-mediated regulation of Na-H exchange. Cell Signal. 1991; 3(5):387-97.
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      60. Ganz MB, Pachter JA, Barber DL. Multiple receptors coupled to adenylate cyclase regulate Na-H exchange independent of cAMP. J Biol Chem. 1990 Jun 5; 265(16):8989-92.
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      61. Barber DL, McGuire ME, Ganz MB. Beta-adrenergic and somatostatin receptors regulate Na-H exchange independent of cAMP. J Biol Chem. 1989 Dec 15; 264(35):21038-42.
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      62. Barber DL, Buchan AM, Leeman SE, Soll AH. Canine enteric submucosal cultures: transmitter release from neurotensin-immunoreactive neurons. Neuroscience. 1989; 32(1):245-53.
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      63. Barber DL, Gregor M, Soll AH. Somatostatin and muscarinic inhibition of canine enteric endocrine cells: cellular mechanisms. Am J Physiol. 1987 Nov; 253(5 Pt 1):G684-9.
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      64. Buchan AM, Barber DL, Gregor M, Soll AH. Morphologic and physiologic studies of canine ileal enteroglucagon-containing cells in short-term culture. Gastroenterology. 1987 Oct; 93(4):791-800.
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      65. Dobner PR, Barber DL, Villa-Komaroff L, McKiernan C. Cloning and sequence analysis of cDNA for the canine neurotensin/neuromedin N precursor. Proc Natl Acad Sci U S A. 1987 May; 84(10):3516-20.
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      66. Buchan AM, Barber DL. Neurotensin-containing neurons in the canine enteric innervation. Neurosci Lett. 1987 Apr 23; 76(1):13-7.
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      67. Barber DL, Buchan AM, Walsh JH, Soll AH. Regulation of neurotensin release from canine enteric primary cell cultures. Am J Physiol. 1986 Mar; 250(3 Pt 1):G385-90.
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      68. Barber DL, Buchan AM, Walsh JH, Soll AH. Isolated canine ileal mucosal cells in short-term culture: a model for study of neurotensin release. Am J Physiol. 1986 Mar; 250(3 Pt 1):G374-84.
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