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    Orion Weiner, PhD

    SchoolUCSF School of Medicine
    DepartmentCardiovascular Research Inst
    Address555 Mission Bay Blvd South
    San Francisco CA 94158
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      University of California, San FranciscoPh.D. Graduate Division (Biochemistry & Molecular Biology)2001

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      Signal transduction networks enable cells to respond to the world around them. To uncover how these signaling networks generate proper responses, we need not only a parts list but also an understanding of how their constituent molecular components work together to process information. I have devoted my lab to developing technologies that will enable us to answer signaling questions that have not been possible to address before. My primary interest is to understand the signaling circuits that organize cell polarity. We take advantage of advanced microscopy techniques in conjunction with techniques to rewire cell signaling or to activate and inhibit signaling on a subcellular level. We aim to move beyond a parts list of components involved in migration to a systems level understanding of cell polarity.

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Liu Z, Weiner OD. Positioning the cleavage furrow: All you need is Rho. J Cell Biol. 2016 Jun 20; 213(6):605-7. PMID: 27325786.
        View in: PubMed
      2. Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol. 2016 Jun; 14(6):e1002474. PMID: 27280401.
        View in: PubMed
      3. Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD. Gß Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. PLoS Biol. 2016 Feb; 14(2):e1002381. PMID: 26890004.
        View in: PubMed
      4. Jost AP, Weiner OD. Probing Yeast Polarity with Acute, Reversible, Optogenetic Inhibition of Protein Function. ACS Synth Biol. 2015 Oct 16; 4(10):1077-85. PMID: 26035630; PMCID: PMC4609243 [Available on 10/16/16].
      5. Lou SS, Diz-Muñoz A, Weiner OD, Fletcher DA, Theriot JA. Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase. J Cell Biol. 2015 Apr 27; 209(2):275-88. PMID: 25918227; PMCID: PMC4411279.
      6. Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015 May 1; 26(9):1629-39. PMID: 25739453; PMCID: PMC4436775.
      7. Tischer D, Weiner OD. Illuminating cell signalling with optogenetic tools. Nat Rev Mol Cell Biol. 2014 Aug; 15(8):551-8. PMID: 25027655; PMCID: PMC4145075.
      8. Graziano BR, Weiner OD. Self-organization of protrusions and polarity during eukaryotic chemotaxis. Curr Opin Cell Biol. 2014 Oct; 30:60-7. PMID: 24998184; PMCID: PMC4177965.
      9. Weiner O. Response to Bell et al. Mol Biol Cell. 2014 Jul 1; 25(13):1945. PMID: 24970486; PMCID: PMC4072568.
      10. Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5896-901. PMID: 24711398; PMCID: PMC4000811.
      11. Hoeller O, Gong D, Weiner OD. How to understand and outwit adaptation. Dev Cell. 2014 Mar 31; 28(6):607-16. PMID: 24697896; PMCID: PMC4012857.
      12. Weiner OD. How should we be selecting our graduate students? Mol Biol Cell. 2014 Feb; 25(4):429-30. PMID: 24525948; PMCID: PMC3923635.
      13. Motta-Mena LB, Reade A, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH. An optogenetic gene expression system with rapid activation and deactivation kinetics. Nat Chem Biol. 2014 Mar; 10(3):196-202. PMID: 24413462; PMCID: PMC3944926.
      14. Toettcher JE, Weiner OD, Lim WA. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 2013 Dec 5; 155(6):1422-34. PMID: 24315106; PMCID: PMC3925772.
      15. Dandekar SN, Park JS, Peng GE, Onuffer JJ, Lim WA, Weiner OD. Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils. Philos Trans R Soc Lond B Biol Sci. 2013; 368(1629):20130008. PMID: 24062580; PMCID: PMC3785960.
      16. Parent CA, Weiner OD. The symphony of cell movement: how cells orchestrate diverse signals and forces to control migration. Curr Opin Cell Biol. 2013 Oct; 25(5):523-5. PMID: 23927870.
        View in: PubMed
      17. Hoeller O, Bolourani P, Clark J, Stephens LR, Hawkins PT, Weiner OD, Weeks G, Kay RR. Two distinct functions for PI3-kinases in macropinocytosis. J Cell Sci. 2013 Sep 15; 126(Pt 18):4296-307. PMID: 23843627; PMCID: PMC3772393.
      18. Yang X, Jost AP, Weiner OD, Tang C. A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast. Mol Biol Cell. 2013 Aug; 24(15):2419-30. PMID: 23761071; PMCID: PMC3727934.
      19. Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Rep. 2013 May 30; 3(5):1607-16. PMID: 23665220; PMCID: PMC3674638.
      20. Diz-Muñoz A, Fletcher DA, Weiner OD. Use the force: membrane tension as an organizer of cell shape and motility. Trends Cell Biol. 2013 Feb; 23(2):47-53. PMID: 23122885; PMCID: PMC3558607.
      21. Woo S, Housley MP, Weiner OD, Stainier DY. Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1. J Cell Biol. 2012 Sep 3; 198(5):941-52. PMID: 22945937; PMCID: PMC3432772.
      22. Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. Network crosstalk dynamically changes during neutrophil polarization. Cell. 2012 May 25; 149(5):1073-83. PMID: 22632971; PMCID: PMC3614011.
      23. Millius A, Watanabe N, Weiner OD. Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging. J Cell Sci. 2012 Mar 1; 125(Pt 5):1165-76. PMID: 22349699; PMCID: PMC3324580.
      24. Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 2012 Jan 20; 148(1-2):175-88. PMID: 22265410; PMCID: PMC3308728.
      25. Toettcher JE, Gong D, Lim WA, Weiner OD. Light-based feedback for controlling intracellular signaling dynamics. Nat Methods. 2011; 8(10):837-9. PMID: 21909100; PMCID: PMC3184382.
      26. Peng GE, Wilson SR, Weiner OD. A pharmacological cocktail for arresting actin dynamics in living cells. Mol Biol Cell. 2011 Nov; 22(21):3986-94. PMID: 21880897; PMCID: PMC3204061.
      27. Toettcher JE, Gong D, Lim WA, Weiner OD. Light control of plasma membrane recruitment using the Phy-PIF system. Methods Enzymol. 2011; 497:409-23. PMID: 21601096; PMCID: PMC3121701.
      28. Toettcher JE, Voigt CA, Weiner OD, Lim WA. The promise of optogenetics in cell biology: interrogating molecular circuits in space and time. Nat Methods. 2011 Jan; 8(1):35-8. PMID: 21191370; PMCID: PMC3024327.
      29. Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell. 2010 Nov 24; 143(5):761-73. PMID: 21111236; PMCID: PMC3058345.
      30. Millius A, Weiner OD. Manipulation of neutrophil-like HL-60 cells for the study of directed cell migration. Methods Mol Biol. 2010; 591:147-58. PMID: 19957129; PMCID: PMC3128798.
      31. Kress H, Park JG, Mejean CO, Forster JD, Park J, Walse SS, Zhang Y, Wu D, Weiner OD, Fahmy TM, Dufresne ER. Cell stimulation with optically manipulated microsources. Nat Methods. 2009 Dec; 6(12):905-9. PMID: 19915561; PMCID: PMC2813772.
      32. Houk AR, Millius A, Weiner OD. Compete globally, bud locally. Cell. 2009 Nov 13; 139(4):656-8. PMID: 19914160; PMCID: PMC2812431.
      33. Levskaya A, Weiner OD, Lim WA, Voigt CA. Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature. 2009 Oct 15; 461(7266):997-1001. PMID: 19749742; PMCID: PMC2989900.
      34. Millius A, Dandekar SN, Houk AR, Weiner OD. Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion. Curr Biol. 2009 Feb 10; 19(3):253-9. PMID: 19200726; PMCID: PMC2705202.
      35. Millius A, Weiner OD. Chemotaxis in neutrophil-like HL-60 cells. Methods Mol Biol. 2009; 571:167-77. PMID: 19763966; PMCID: PMC2812563.
      36. Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221. PMID: 17696648; PMCID: PMC1945041.
      37. Pestonjamasp KN, Forster C, Sun C, Gardiner EM, Bohl B, Weiner O, Bokoch GM, Glogauer M. Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood. 2006 Oct 15; 108(8):2814-20. PMID: 16809619; PMCID: PMC1895589.
      38. Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol. 2006 Feb; 4(2):e38. PMID: 16417406; PMCID: PMC1334198.
      39. Bourne HR, Weiner O. A chemical compass. Nature. 2002 Sep 5; 419(6902):21. PMID: 12214215.
        View in: PubMed
      40. Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, Bourne HR. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nat Cell Biol. 2002 Jul; 4(7):513-8. PMID: 12080345.
        View in: PubMed
      41. Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol. 2002 Jul; 4(7):509-13. PMID: 12080346; PMCID: PMC2823287.
      42. Weiner OD. Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma? Curr Biol. 2002 Jun 25; 12(12):R429-31. PMID: 12123595; PMCID: PMC2819105.
      43. Weiner OD. Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Curr Opin Cell Biol. 2002 Apr; 14(2):196-202. PMID: 11891119; PMCID: PMC2819118.
      44. Insall RH, Weiner OD. PIP3, PIP2, and cell movement--similar messages, different meanings? Dev Cell. 2001 Dec; 1(6):743-7. PMID: 11740936; PMCID: PMC2819114.
      45. Rickert P, Weiner OD, Wang F, Bourne HR, Servant G. Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol. 2000 Nov; 10(11):466-73. PMID: 11050418; PMCID: PMC2819116.
      46. Servant G, Weiner OD, Herzmark P, Balla T, Sedat JW, Bourne HR. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science. 2000 Feb 11; 287(5455):1037-40. PMID: 10669415; PMCID: PMC2822871.
      47. Kalman D, Weiner OD, Goosney DL, Sedat JW, Finlay BB, Abo A, Bishop JM. Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals. Nat Cell Biol. 1999 Oct; 1(6):389-91. PMID: 10559969; PMCID: PMC2828053.
      48. Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR. Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol. 1999 Jun; 1(2):75-81. PMID: 10559877; PMCID: PMC2828058.
      49. Servant G, Weiner OD, Neptune ER, Sedat JW, Bourne HR. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell. 1999 Apr; 10(4):1163-78. PMID: 10198064; PMCID: PMC25243.
      50. Weiner OD, Zorn AM, Krieg PA, Bittner GD. Medium weight neurofilament mRNA in goldfish Mauthner axoplasm. Neurosci Lett. 1996 Aug 2; 213(2):83-6. PMID: 8858614; PMCID: PMC2830807.
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