Guo Huang, PhD

Title(s)Associate Professor, Cardiovascular Research Inst
SchoolSchool of Medicine
Address555 Mission Bay Blvd South, #352V
San Francisco CA 94158
Phone415-502-2873
ORCID ORCID Icon0000-0002-4335-9123 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    International Society for Heart Research North American Section2023Mid-Career Investigator Research Scholarship Award
    American Heart Association2022Established Investigator Award
    American Heart Association2020Transformational Project Award
    Department of Defense2019Discovery Award
    UCSF2018Program for Breakthrough Biomedical Research
    UCSF2017Independence Award
    American Federation for Aging Research2016  - 2018AFAR Junior Faculty Grant
    March of Dimes Foundation2016  - 2018Basil O'Connor Starter Award
    American Heart Association2016  - 2018AHA Career Beginning Grant-in-aid Award
    UCSF2015Academic Senator Award
    UCSF2014  - 2015Program for Breakthrough Biomedical Research
    Edward Mallinckrodt Jr. Foundation2014  - 2017Mallinckrodt Young Investigaor Grants
    LSRF2014  - 2014O'Donnell Foundation Fund
    LSRF2009  - 2012Life Sciences Research Foundation Fellowship
    NIH/NHBLI2012  - 2017NIH Pathway to Independence Award (K99/R00)

    Collapse Overview 
    Collapse Overview
    B.S. Peking University (summa cum laude)
    Ph.D. Johns Hopkins Medical Institute (Phi Beta Kappa)
    Postdoc. UT Southwestern Medical Center (Life Sciences Research Foundation Fellow)

    Collapse Research 
    Collapse Research Activities and Funding
    Genetic circuitry governing heart growth and repair
    NIH/NHLBI R01HL160819Mar 1, 2022 - Feb 28, 2027
    Role: Principal Investigator
    Molecular control of cardiac regenerative potential
    NIH R01HL138456Dec 1, 2017 - Nov 30, 2022
    Role: PI
    Retinoic Acid Signaling in Heart Development and Regeneration
    NIH/NHBLI R00HL114738Mar 1, 2014 - Feb 28, 2018
    Role: Principal Investigator
    Retinoic Acid Signaling in Heart Development and Regeneration
    NIH K99HL114738Aug 15, 2012 - Jun 30, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An injury-responsive mmp14b enhancer is required for heart regeneration. Sci Adv. 2023 12; 9(48):eadh5313. Zlatanova I, Sun F, Wu RS, Chen X, Lau BH, Colombier P, Sinha T, Celona B, Xu SM, Materna SC, Huang GN, Black BL. PMID: 38019918; PMCID: PMC10686572.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Quantitative Three-dimensional Label-free Digital Holographic Imaging of Cardiomyocyte Size, Ploidy, and Cell Division. bioRxiv. 2023 Nov 04. Park S, Huang H, Ross I, Moreno J, Khyeam S, Simmons J, Huang GN, Payumo AY. PMID: 37961676; PMCID: PMC10635088.
      View in: PubMed   Mentions:
    3. Two decades of heart regeneration research: Cardiomyocyte proliferation and beyond. WIREs Mech Dis. 2024 Jan-Feb; 16(1):e1629. Huang H, Huang GN, Payumo AY. PMID: 37700522; PMCID: PMC10840678.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Unlocking cardiomyocyte renewal potential for myocardial regeneration therapy. J Mol Cell Cardiol. 2023 04; 177:9-20. Mehdipour M, Park S, Huang GN. PMID: 36801396; PMCID: PMC10699255.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    5. Visualization of regenerating and repairing hearts. Clin Sci (Lond). 2022 05 27; 136(10):787-798. Powers N, Huang GN. PMID: 35621122; PMCID: PMC9886236.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    6. Mending a broken heart with novel cardiogenic small molecules. Cell Regen. 2022 May 05; 11(1):20. Powers N, Huang GN. PMID: 35511305; PMCID: PMC9072610.
      View in: PubMed   Mentions:
    7. Adrenergic-Thyroid Hormone Interactions Drive Postnatal Thermogenesis and Loss of Mammalian Heart Regenerative Capacity. Circulation. 2021 09 21; 144(12):1000-1003. Payumo AY, Chen X, Hirose K, Chen X, Hoang A, Khyeam S, Yu H, Wang J, Chen Q, Powers N, Chen L, Bigley RB, Lovas J, Hu G, Huang GN. PMID: 34543065; PMCID: PMC8457303.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    8. Endocrine Influence on Cardiac Metabolism in Development and Regeneration. Endocrinology. 2021 09 01; 162(9). Graham N, Huang GN. PMID: 33880553; PMCID: PMC8282123.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. Genetic, Epigenetic, and Post-Transcriptional Basis of Divergent Tissue Regenerative Capacities Among Vertebrates. Adv Genet (Hoboken). 2021 Jun; 2(2). Khyeam S, Lee S, Huang GN. PMID: 34423307; PMCID: PMC8372189.
      View in: PubMed   Mentions: 10  
    10. Vertebrate cardiac regeneration: evolutionary and developmental perspectives. Cell Regen. 2021 Mar 01; 10(1):6. Cutie S, Huang GN. PMID: 33644818; PMCID: PMC7917145.
      View in: PubMed   Mentions: 11  
    11. Hormonal control of cardiac regenerative potential. Endocr Connect. 2021 Jan; 10(1):R25-R35. Amram AV, Cutie S, Huang GN. PMID: 33320107; PMCID: PMC7923045.
      View in: PubMed   Mentions: 8  
    12. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 11 05; 5(21). Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. PMID: 32990679; PMCID: PMC7710308.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    13. The coevolutionary process of restaurant CSR in the time of mega disruption. Int J Hosp Manag. 2021 Jan; 92:102684. Ou J, Wong IA, Huang GI. PMID: 33052164; PMCID: PMC7543789.
      View in: PubMed   Mentions: 6  
    14. In vitro and in vivo roles of glucocorticoid and vitamin D receptors in the control of neonatal cardiomyocyte proliferative potential. J Mol Cell Cardiol. 2020 05; 142:126-134. Cutie S, Payumo AY, Lunn D, Huang GN. PMID: 32289320; PMCID: PMC7395852.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    15. Lamin B2, Guardian of Cardiomyocyte Nuclear Division. Dev Cell. 2020 04 06; 53(1):5-7. Payumo AY, Huang GN. PMID: 32259493.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Defined factors to reactivate cell cycle activity in adult mouse cardiomyocytes. Sci Rep. 2019 12 11; 9(1):18830. Judd J, Lovas J, Huang GN. PMID: 31827131; PMCID: PMC6906479.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    17. Evidence for hormonal control of heart regenerative capacity during endothermy acquisition. Science. 2019 04 12; 364(6436):184-188. Hirose K, Payumo AY, Cutie S, Hoang A, Zhang H, Guyot R, Lunn D, Bigley RB, Yu H, Wang J, Smith M, Gillett E, Muroy SE, Schmid T, Wilson E, Field KA, Reeder DM, Maden M, Yartsev MM, Wolfgang MJ, Grützner F, Scanlan TS, Szweda LI, Buffenstein R, Hu G, Flamant F, Olgin JE, Huang GN. PMID: 30846611; PMCID: PMC6541389.
      View in: PubMed   Mentions: 160     Fields:    Translation:AnimalsCells
    18. Unconventional Functions of Muscles in Planarian Regeneration. Dev Cell. 2017 12 18; 43(6):657-658. Cutie S, Hoang AT, Payumo AY, Huang GN. PMID: 29257948; PMCID: PMC6057794.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. Insights into nuclear dynamics using live-cell imaging approaches. Wiley Interdiscip Rev Syst Biol Med. 2017 03; 9(2). Bigley RB, Payumo AY, Alexander JM, Huang GN. PMID: 28078793; PMCID: PMC5315593.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    20. Isolation, Culture and Transduction of Adult Mouse Cardiomyocytes. J Vis Exp. 2016 Aug 28; (114). Judd J, Lovas J, Huang GN. PMID: 27685811; PMCID: PMC5091965.
      View in: PubMed   Mentions: 15     Fields:    
    21. C/EBP transcription factors mediate epicardial activation during heart development and injury. Science. 2012 Dec 21; 338(6114):1599-603. Huang GN, Thatcher JE, McAnally J, Kong Y, Qi X, Tan W, DiMaio JM, Amatruda JF, Gerard RD, Hill JA, Bassel-Duby R, Olson EN. PMID: 23160954; PMCID: PMC3613149.
      View in: PubMed   Mentions: 125     Fields:    Translation:AnimalsCells
    22. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature. 2012 May 13; 485(7400):599-604. Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. PMID: 22660318; PMCID: PMC3367390.
      View in: PubMed   Mentions: 598     Fields:    Translation:AnimalsCells
    23. T Cell Calcium Mobilization Study (Flow Cytometry). Bio Protoc. 2012 May 05; 2(9). Huang GN. PMID: 29552583; PMCID: PMC5856153.
      View in: PubMed   Mentions:
    24. Biotinylation of Cell Surface Proteins. Bio Protoc. 2012 May 05; 2(9). Huang GN. PMID: 29552582; PMCID: PMC5856152.
      View in: PubMed   Mentions: 8  
    25. Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. Neuron. 2009 Nov 25; 64(4):471-83. Shim S, Yuan JP, Kim JY, Zeng W, Huang G, Milshteyn A, Kern D, Muallem S, Ming GL, Worley PF. PMID: 19945390; PMCID: PMC2786904.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    26. STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction. Mol Cell. 2008 Nov 07; 32(3):439-48. Zeng W, Yuan JP, Kim MS, Choi YJ, Huang GN, Worley PF, Muallem S. PMID: 18995841; PMCID: PMC2586614.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansCells
    27. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science. 2008 Jan 25; 319(5862):476-81. Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF. PMID: 18218901; PMCID: PMC3602998.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    28. STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels. Nat Cell Biol. 2007 Jun; 9(6):636-45. Yuan JP, Zeng W, Huang GN, Worley PF, Muallem S. PMID: 17486119; PMCID: PMC2699187.
      View in: PubMed   Mentions: 245     Fields:    Translation:HumansCells
    29. STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels. Nat Cell Biol. 2006 Sep; 8(9):1003-10. Huang GN, Zeng W, Kim JY, Yuan JP, Han L, Muallem S, Worley PF. PMID: 16906149.
      View in: PubMed   Mentions: 307     Fields:    Translation:HumansCells
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