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Jorge Oksenberg, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentNeurology
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-476-1335
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    Collapse Biography 
    Collapse Awards and Honors
    VA Multiple Sclerosis Center of Excellence 2009The John N. Whitaker Memorial Lecture
    UCSF2005G.A. Zimmermann Endowed Chair in Neurology

    Collapse Overview 
    Collapse Overview
    Immune-mediated neurological impairment is the outcome of a rather extensive and coordinated series of events that include peripheral lymphocyte activation, disruption of the blood-brain barrier, cellular infiltration into the brain parenchyma, local inflammation and tissue injury. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules (including free radicals, proteases, vasoactive amines, and excitatory neurotransmitters) induce and regulate numerous critical cell functions that perpetuate inflammation, leading to tissue injury, neuro-degeneration, and neurological deficits. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extend conditioned by the unique amino acid sequences that define allelic variants on each of the participating molecules. Genes, either in their germline configuration and/or as part of complex functional networks, play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy.

    The principal aim of our laboratory (see link below) is to identify the major genetic factors that predispose to autoimmunity in the central nervous system and modulate disease presentation and progression. The availability of highly sensitive and high-capacity methods for analysis of gene variation and expression combined with the implementation of algorithms that predict behaviors in complex biological circuits provides an outstanding opportunity to facilitate progress in the integration of multiple data sources and functional interpretation of physiological and laboratory results. Our goal is to apply novel molecular, informatic, statistical, and epidemiological approaches to illuminate fully the genetics of autoimmune demyelination. Specifically, our research plan includes:
    • Genome wide gene/haplotype mapping for the discovery of MS genes
    • Genotype-phenotype correlations in MS
    • Gene-environment correlations in MS
    • Genomic and clinical study of MS populations at low and intermediate risk
    • MS pharmacogenomics
    • Gene expression networks in human and experimental neuroinflammation


    Collapse Research 
    Collapse Research Activities and Funding
    MHC variation at high resolution in multiple sclerosis
    NIH/NINDS R01NS102153Aug 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Immunogenetic Determinants of Disease Risk in Neurological Disease
    NIH/NINDS U19NS095774Jul 1, 2015 - Jul 31, 2020
    Role: Principal Investigator
    The contribution of common and rare variants to autoimmunity in African Americans
    NIH/NINDS R01NS076492Aug 15, 2011 - Apr 30, 2015
    Role: Principal Investigator
    Immunogenetic Studies in Multiple Sclerosis
    NIH/NINDS R01NS046297Jul 16, 2003 - Dec 31, 2014
    Role: Principal Investigator
    Immunomodulation in Multiple Sclerosis by Interferon B
    NIH/NINDS R01NS042911Sep 30, 2002 - Aug 31, 2007
    Role: Principal Investigator
    IMMUNOLOGICAL BASIS OF EPILEPSY
    NIH/NINDS R01NS035761Jun 16, 1997 - May 31, 2001
    Role: Principal Investigator
    Gene linkage study of multiple sclerosis sibling pairs
    NIH/NINDS R01NS026799Dec 1, 1988 - Jul 31, 2019
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse In The News
    Collapse Global Health

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Benedek G, Meza-Romero R, Jordan K, Zhang Y, Nguyen H, Kent G, Li J, Siu E, Frazer J, Piecychna M, Du X, Sreih A, Leng L, Wiedrick J, Caillier SJ, Offner H, Oksenberg J, Yadav V, Bourdette D, Bucala R, Vandenbark AA. MIF and D-DT are potential disease severity modifiers in male MS subjects. Proc Natl Acad Sci U S A. 2017 Sep 18. PMID: 28923927.
      View in: PubMed
    2. Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI, Cardiel MH, Catoggio L, Cervera R, Cucho-Venegas JM, Dahlqvist SR, D'Alfonso S, Da Silva BM, de la Rúa Figueroa I, Doria A, Edberg JC, Endreffy E, Esquivel-Valerio JA, Fortin PR, Freedman BI, Frostegård J, García MA, de la Torre IG, Gilkeson GS, Gladman DD, Gunnarsson I, Guthridge JM, Huggins JL, James JA, Kallenberg CGM, Kamen DL, Karp DR, Kaufman KM, Kottyan LC, Kovács L, Laustrup H, Lauwerys BR, Li QZ, Maradiaga-Ceceña MA, Martín J, McCune JM, McWilliams DR, Merrill JT, Miranda P, Moctezuma JF, Nath SK, Niewold TB, Orozco L, Ortego-Centeno N, Petri M, Pineau CA, Pons-Estel BA, Pope J, Raj P, Ramsey-Goldman R, Reveille JD, Russell LP, Sabio JM, Aguilar-Salinas CA, Scherbarth HR, Scorza R, Seldin MF, Sjöwall C, Svenungsson E, Thompson SD, Toloza SMA, Truedsson L, Tusié-Luna T, Vasconcelos C, Vilá LM, Wallace DJ, Weisman MH, Wither JE, Bhangale T, Oksenberg J, Rioux JD, Gregersen PK, Syvänen AC, Rönnblom L, Criswell LA, Jacob CO, Sivils KL, Tsao BP, Schanberg LE, Behrens TW, Silverman ED, Alarcón-Riquelme ME, Kimberly RP, Harley JB, Wakeland EK, Graham RR, Gaffney PM, Vyse TJ. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun. 2017 07 17; 8:16021. PMID: 28714469.
      View in: PubMed
    3. Isobe N, Oksenberg J, Henry RG. HLA Genetic Risk Burden in Multiple Sclerosis-Reply. JAMA Neurol. 2016 Dec 01; 73(12):1501-1502. PMID: 27775754.
      View in: PubMed
    4. Vigo T, Procaccini C, Ferrara G, Baranzini S, Oksenberg J, Matarese G, Diaspro A, Kerlero de Rosbo N, Uccelli A. IFN-? orchestrates mesenchymal stem cell plasticity through the signal transducer and activator of transcription 1 and 3 and mammalian target of rapamycin pathways. J Allergy Clin Immunol. 2017 May; 139(5):1667-1676. PMID: 27670240.
      View in: PubMed
    5. Didonna A, Cekanaviciute E, Oksenberg J, Baranzini SE. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 Aug 22; 6:31603. PMID: 27546286; PMCID: PMC4992865.
    6. Cree B, Gourraud PA, Oksenberg J, Bevan C, Crabtree-Hartman E, Gelfand JM, Goodin DS, Graves J, Green AJ, Mowry E, Okuda DT, Pelletier D, von Büdingen HC, Zamvil SS, Agrawal A, Caillier S, Ciocca C, Gomez R, Kanner R, Lincoln R, Lizee A, Qualley P, Santaniello A, Suleiman L, Bucci M, Panara V, Papinutto N, Stern WA, Zhu AH, Cutter GR, Baranzini S, Henry RG, Hauser SL, et al. Long-term evolution of multiple sclerosis disability in the treatment era. Ann Neurol. 2016 Oct; 80(4):499-510. PMID: 27464262.
      View in: PubMed
    7. Norman PJ, Hollenbach JA, Nemat-Gorgani N, Marin WM, Norberg SJ, Ashouri E, Jayaraman J, Wroblewski EE, Trowsdale J, Rajalingam R, Oksenberg J, Chiaroni J, Guethlein LA, Traherne JA, Ronaghi M, Parham P. Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing. Am J Hum Genet. 2016 Aug 04; 99(2):375-91. PMID: 27486779; PMCID: PMC4974113 [Available on 02/04/17].
    8. George MF, Briggs FB, Shao X, Gianfrancesco MA, Kockum I, Harbo HF, Celius EG, Bos SD, Hedström A, Shen L, Bernstein A, Alfredsson L, Hillert J, Olsson T, Patsopoulos NA, De Jager PL, Oturai AB, Søndergaard HB, Sellebjerg F, Sorensen PS, Gomez R, Caillier SJ, Cree BA, Oksenberg J, Hauser SL, D'Alfonso S, Leone MA, Martinelli Boneschi F, Sorosina M, van der Mei I, Taylor BV, Zhou Y, Schaefer C, Barcellos LF. Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies. Neurol Genet. 2016 Aug; 2(4):e87. PMID: 27540591; PMCID: PMC4974846.
    9. Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D'Alfonso S, Demaerel P, Dubois B, Filippi M, Fleischer V, Fontaine B, Gaetano L, Goris A, Graetz C, Gröger A, Groppa S, Hafler DA, Harbo HF, Hemmer B, Jordan K, Kappos L, Kirkish G, Llufriu S, Magon S, Martinelli-Boneschi F, McCauley J, Montalban X, Muhlau M, Pelletier D, Pattany PM, Pericak-Vance M, Rebeix I, Rocca M, Rovira A, Schlaeger R, Saiz A, Sprenger T, Stecco A, Uitdehaag BM, Villoslada P, Wattjes MP, Weiner H, Wuerfel J, Zimmer C, Zipp F, Hauser S, Oksenberg J, Henry RG. Power estimation for non-standardized multisite studies. Neuroimage. 2016 Jul 01; 134:281-294. PMID: 27039700.
      View in: PubMed
    10. Khankhanian P, Cozen W, Himmelstein DS, Madireddy L, Din L, van den Berg A, Matsushita T, Glaser SL, Moré JM, Smedby KE, Baranzini SE, Mack TM, Lizée A, de Sanjosé S, Gourraud PA, Nieters A, Hauser SL, Cocco P, Maynadié M, Foretová L, Staines A, Delahaye-Sourdeix M, Li D, Bhatia S, Melbye M, Onel K, Jarrett R, McKay JD, Oksenberg J, Hjalgrim H. Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis. Int J Epidemiol. 2016 Jun; 45(3):728-40. PMID: 26971321; PMCID: PMC5005944.
    11. Hollenbach JA, Pando MJ, Caillier SJ, Gourraud PA, Oksenberg J. The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans. Genes Immun. 2016 04; 17(3):199-202. PMID: 26866467.
      View in: PubMed
    12. Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg J. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8. PMID: 26433934; PMCID: PMC5007634 [Available on 12/15/16].
    13. Bustamante MF, Morcillo-Suárez C, Malhotra S, Rio J, Leyva L, Fernández O, Zettl UK, Killestein J, Brassat D, García-Merino JA, Sánchez AJ, Urcelay E, Alvarez-Lafuente R, Villar LM, Alvarez-Cermeño JC, Farré X, Lechner-Scott J, Vandenbroeck K, Rodríguez-Antigüedad A, Drulovic JS, Martinelli Boneschi F, Chan A, Oksenberg J, Navarro A, Montalban X, Comabella M. Pharmacogenomic study in patients with multiple sclerosis: Responders and nonresponders to IFN-ß. Neurol Neuroimmunol Neuroinflamm. 2015 Oct; 2(5):e154. PMID: 26445728; PMCID: PMC4582905.
    14. Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M, Shah TS, Patsopoulos NA, Alfredsson L, Anderson CA, Attfield KE, Baranzini SE, Barrett J, Binder TM, Booth D, Buck D, Celius EG, Cotsapas C, D'Alfonso S, Dendrou CA, Donnelly P, Dubois B, Fontaine B, Lar Fugger L, Goris A, Gourraud PA, Graetz C, Hemmer B, Hillert J, Kockum I, Leslie S, Lill CM, Martinelli-Boneschi F, Oksenberg J, Olsson T, Oturai A, Saarela J, Søndergaard HB, Spurkland A, Taylor B, Winkelmann J, Zipp F, Haines JL, Pericak-Vance MA, Spencer CC, Stewart G, Hafler DA, Ivinson AJ, Harbo HF, Hauser SL, De Jager PL, Compston A, McCauley JL, Sawcer S, McVean G. Class II HLA interactions modulate genetic risk for multiple sclerosis. Nat Genet. 2015 Oct; 47(10):1107-1113. PMID: 26343388; PMCID: PMC4874245.
    15. Khankhanian P, Matsushita T, Madireddy L, Lizée A, Din L, Moré JM, Gourraud PA, Hauser SL, Baranzini SE, Oksenberg J. Genetic contribution to multiple sclerosis risk among Ashkenazi Jews. BMC Med Genet. 2015 Jul 28; 16:55. PMID: 26212423; PMCID: PMC4557862.
    16. Hollenbach JA, Oksenberg J. The immunogenetics of multiple sclerosis: A comprehensive review. J Autoimmun. 2015 Nov; 64:13-25. PMID: 26142251; PMCID: PMC4687745 [Available on 11/01/16].
    17. Tranah GJ, Santaniello A, Caillier SJ, D'Alfonso S, Martinelli Boneschi F, Hauser SL, Oksenberg J. Mitochondrial DNA sequence variation in multiple sclerosis. Neurology. 2015 Jul 28; 85(4):325-30. PMID: 26136518; PMCID: PMC4520811.
    18. Isobe N, Madireddy L, Khankhanian P, Matsushita T, Caillier SJ, Moré JM, Gourraud PA, McCauley JL, Beecham AH, Piccio L, Herbert J, Khan O, Cohen J, Stone L, Santaniello A, Cree BA, Onengut-Gumuscu S, Rich SS, Hauser SL, Sawcer S, Oksenberg J. An ImmunoChip study of multiple sclerosis risk in African Americans. Brain. 2015 Jun; 138(Pt 6):1518-30. PMID: 25818868; PMCID: PMC4553906.
    19. Matsushita T, Madireddy L, Sprenger T, Khankhanian P, Magon S, Naegelin Y, Caverzasi E, Lindberg RL, Kappos L, Hauser SL, Oksenberg J, Henry R, Pelletier D, Baranzini SE. Genetic associations with brain cortical thickness in multiple sclerosis. Genes Brain Behav. 2015 Feb; 14(2):217-27. PMID: 25684059; PMCID: PMC4857705.
    20. Didonna A, Oksenberg J. Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta. 2015 Sep 20; 449:16-22. PMID: 25661088; PMCID: PMC4524789 [Available on 09/20/16].
    21. Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Annese V, Hauser SL, Oksenberg J, Thomsen I, Leslie S, Daly MJ, Van Steen K, Duerr RH, Barrett JC, McGovern DP, Schumm LP, Traherne JA, Carrington MN, Kosmoliaptsis V, Karlsen TH, Franke A, Rioux JD. High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat Genet. 2015 Feb; 47(2):172-9. PMID: 25559196; PMCID: PMC4310771.
    22. Nickles D, Madireddy L, Patel N, Isobe N, Miller BL, Baranzini SE, Kramer JH, Oksenberg J. Whole genome sequences of 2 octogenarians with sustained cognitive abilities. Neurobiol Aging. 2015 Mar; 36(3):1435-8. PMID: 25618617; PMCID: PMC4346472.
    23. Gourraud PA, Khankhanian P, Cereb N, Yang SY, Feolo M, Maiers M, Rioux JD, Hauser S, Oksenberg J. HLA diversity in the 1000 genomes dataset. PLoS One. 2014; 9(7):e97282. PMID: 24988075; PMCID: PMC4079705.
    24. Oksenberg J. Decoding multiple sclerosis: an update on genomics and future directions. Expert Rev Neurother. 2013 Dec; 13(12 Suppl):11-9. PMID: 24289837.
      View in: PubMed
    25. Hauser SL, Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg J. Quo vadis? Peering into the future. Ann Neurol. 2013 Dec; 74(6):A5-7. PMID: 24448838.
      View in: PubMed
    26. Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T, Gourraud PA, Stranger BE, Oksenberg J, Olsson T, Taylor BV, Sawcer S, Hafler DA, Carrington M, De Jager PL, de Bakker PI. Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet. 2013 Nov; 9(11):e1003926. PMID: 24278027; PMCID: PMC3836799.
    27. Goris A, van Setten J, Diekstra F, Ripke S, Patsopoulos NA, Sawcer SJ, van Es M, Andersen PM, Melki J, Meininger V, Hardiman O, Landers JE, Brown RH, Shatunov A, Leigh N, Al-Chalabi A, Shaw CE, Traynor BJ, Chiò A, Restagno G, Mora G, Ophoff RA, Oksenberg J, Van Damme P, Compston A, Robberecht W, Dubois B, van den Berg LH, De Jager PL, Veldink JH, de Bakker PI. No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. Hum Mol Genet. 2014 Apr 01; 23(7):1916-22. PMID: 24234648; PMCID: PMC3943520.
    28. Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg J, Stewart A, Hauser SL. Have the Annals editors added value? Ann Neurol. 2013 Nov; 74(5):A7-9. PMID: 24353220.
      View in: PubMed
    29. Harbo HF, Isobe N, Berg-Hansen P, Bos SD, Caillier SJ, Gustavsen MW, Mero IL, Celius EG, Hauser SL, Oksenberg J, Gourraud PA. Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis. Mult Scler. 2014 May; 20(6):660-8. PMID: 24099750; PMCID: PMC4066985.
    30. Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg J, Hintzen R, Barcellos LF, Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Søndergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara I, Esposito F, Evangelou N, Fiddes B, Field J, Franke A, Freeman C, Frohlich IY, Galimberti D, Gieger C, Gourraud PA, Graetz C, Graham A, Grummel V, Guaschino C, Hadjixenofontos A, Hakonarson H, Halfpenny C, Hall G, Hall P, Hamsten A, Harley J, Harrower T, Hawkins C, Hellenthal G, Hillier C, Hobart J, Hoshi M, Hunt SE, Jagodic M, Jelcic I, Jochim A, Kendall B, Kermode A, Kilpatrick T, Koivisto K, Konidari I, Korn T, Kronsbein H, Langford C, Larsson M, Lathrop M, Lebrun-Frenay C, Lechner-Scott J, Lee MH, Leone MA, Leppä V, Liberatore G, Lie BA, Lill CM, Lindén M, Link J, Luessi F, Lycke J, Macciardi F, Männistö S, Manrique CP, Martin R, Martinelli V, Mason D, Mazibrada G, McCabe C, Mero IL, Mescheriakova J, Moutsianas L, Myhr KM, Nagels G, Nicholas R, Nilsson P, Piehl F, Pirinen M, Price SE, Quach H, Reunanen M, Robberecht W, Robertson NP, Rodegher M, Rog D, Salvetti M, Schnetz-Boutaud NC, Sellebjerg F, Selter RC, Schaefer C, Shaunak S, Shen L, Shields S, Siffrin V, Slee M, Sorensen PS, Sorosina M, Sospedra M, Spurkland A, Strange A, Sundqvist E, Thijs V, Thorpe J, Ticca A, Tienari P, van Duijn C, Visser EM, Vucic S, Westerlind H, Wiley JS, Wilkins A, Wilson JF, Winkelmann J, Zajicek J, Zindler E, Haines JL, Pericak-Vance MA, Ivinson AJ, Stewart G, Hafler D, Hauser SL, Compston A, McVean G, De Jager P, Sawcer SJ, McCauley JL. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 2013 Nov; 45(11):1353-60. PMID: 24076602; PMCID: PMC3832895.
    31. Hauser SL, Chan JR, Oksenberg J. Multiple sclerosis: Prospects and promise. Ann Neurol. 2013 Sep; 74(3):317-27. PMID: 23955638.
      View in: PubMed
    32. Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Pekarek K, Sobel RA, Hauser SL, Oksenberg J, Zamvil SS, Baranzini SE. Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity. J Exp Med. 2013 Jul 01; 210(7):1301-9. PMID: 23797093; PMCID: PMC3698524.
    33. Rossi S, Studer V, Moscatelli A, Motta C, Coghe G, Fenu G, Caillier S, Buttari F, Mori F, Barbieri F, Castelli M, De Chiara V, Monteleone F, Mancino R, Bernardi G, Baranzini SE, Marrosu MG, Oksenberg J, Centonze D. Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis. PLoS One. 2013; 8(6):e67357. PMID: 23840674; PMCID: PMC3696106.
    34. Isobe N, Gourraud PA, Harbo HF, Caillier SJ, Santaniello A, Khankhanian P, Maiers M, Spellman S, Cereb N, Yang S, Pando MJ, Piccio L, Cross AH, De Jager PL, Cree BA, Hauser SL, Oksenberg J. Genetic risk variants in African Americans with multiple sclerosis. Neurology. 2013 Jul 16; 81(3):219-27. PMID: 23771490; PMCID: PMC3770164.
    35. Nickles D, Chen HP, Li MM, Khankhanian P, Madireddy L, Caillier SJ, Santaniello A, Cree BA, Pelletier D, Hauser SL, Oksenberg J, Baranzini SE. Blood RNA profiling in a large cohort of multiple sclerosis patients and healthy controls. Hum Mol Genet. 2013 Oct 15; 22(20):4194-205. PMID: 23748426; PMCID: PMC3781642.
    36. Swaminathan B, Cuapio A, Alloza I, Matesanz F, Alcina A, García-Barcina M, Fedetz M, Fernández O, Lucas M, Orpez T, Pinto-Medel MJ, Otaegui D, Olascoaga J, Urcelay E, Ortiz MA, Arroyo R, Oksenberg J, Antigüedad A, Tolosa E, Vandenbroeck K. Fine mapping and functional analysis of the multiple sclerosis risk gene CD6. PLoS One. 2013; 8(4):e62376. PMID: 23638056; PMCID: PMC3634811.
    37. Ban M, Caillier S, Mero IL, Myhr KM, Celius EG, Aarseth J, Torkildsen Ø, Harbo HF, Oksenberg J, Hauser SL, Sawcer S, Compston A. No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis. Ann Neurol. 2013 Mar; 73(3):430-2. PMID: 23444327; PMCID: PMC3631291.
    38. Gourraud PA, Sdika M, Khankhanian P, Henry RG, Beheshtian A, Matthews PM, Hauser SL, Oksenberg J, Pelletier D, Baranzini SE. A genome-wide association study of brain lesion distribution in multiple sclerosis. Brain. 2013 Apr; 136(Pt 4):1012-24. PMID: 23412934; PMCID: PMC3613709.
    39. McElroy JP, Krupp LB, Johnson BA, McCauley JL, Qi Z, Caillier SJ, Gourraud PA, Yu J, Nathanson L, Belman AL, Hauser SL, Waubant E, Hedges DJ, Oksenberg J. Copy number variation in pediatric multiple sclerosis. Mult Scler. 2013 Jul; 19(8):1014-21. PMID: 23239789.
      View in: PubMed
    40. Pappas DJ, Gabatto PA, Oksenberg D, Khankhanian P, Baranzini SE, Gan L, Oksenberg J. Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules. Neuroscience. 2012 Dec 13; 226:10-20. PMID: 22986168; PMCID: PMC3489981.
    41. Nickles D, Madireddy L, Yang S, Khankhanian P, Lincoln S, Hauser SL, Oksenberg J, Baranzini SE. In depth comparison of an individual's DNA and its lymphoblastoid cell line using whole genome sequencing. BMC Genomics. 2012 Sep 14; 13:477. PMID: 22974163; PMCID: PMC3473256.
    42. Su SY, Kasberger J, Baranzini S, Byerley W, Liao W, Oksenberg J, Sherr E, Jorgenson E. Detection of identity by descent using next-generation whole genome sequencing data. BMC Bioinformatics. 2012 Jun 06; 13:121. PMID: 22672699; PMCID: PMC3403908.
    43. Hedges DJ, Hamilton-Nelson KL, Sacharow SJ, Nations L, Beecham GW, Kozhekbaeva ZM, Butler BL, Cukier HN, Whitehead PL, Ma D, Jaworski JM, Nathanson L, Lee JM, Hauser SL, Oksenberg J, Cuccaro ML, Haines JL, Gilbert JR, Pericak-Vance MA. Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci. Mol Autism. 2012 Apr 02; 3:2. PMID: 22472195; PMCID: PMC3352055.
    44. Stewart AF, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg J, Johnston SC, Hauser SL. Fighting decision fatigue. Ann Neurol. 2012 Jan; 71(1):A5-A15. PMID: 22275264.
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    45. Patsopoulos NA, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalbán J, Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S, Filippi M, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth DR, Broadley S, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg J, Pericak-Vance M, Sawcer SJ, De Jager PL, Hafler DA, de Bakker PI. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol. 2011 Dec; 70(6):897-912. PMID: 22190364; PMCID: PMC3247076.
    46. Oksenberg J, Hauser SL. Decoding multiple sclerosis. Ann Neurol. 2011 Dec; 70(6):A5-7. PMID: 22190375.
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    123. Pedemonte E, Benvenuto F, Casazza S, Mancardi G, Oksenberg J, Uccelli A, Baranzini SE. The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse. BMC Genomics. 2007 Mar 06; 8:65. PMID: 17341312; PMCID: PMC1821333.
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    128. Hauser SL, Oksenberg J. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron. 2006 Oct 05; 52(1):61-76. PMID: 17015227.
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    137. Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg J, Hafler DA. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet. 2005 Oct; 37(10):1113-8. PMID: 16186815.
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    138. Frohman EM, Filippi M, Stuve O, Waxman SG, Corboy J, Phillips JT, Lucchinetti C, Wilken J, Karandikar N, Hemmer B, Monson N, De Keyser J, Hartung H, Steinman L, Oksenberg J, Cree BA, Hauser S, Racke MK. Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions. Arch Neurol. 2005 Sep; 62(9):1345-56. PMID: 16157741.
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    145. Brassat D, Salemi G, Barcellos LF, McNeill G, Proia P, Hauser SL, Oksenberg J, Savettieri G. The HLA locus and multiple sclerosis in Sicily. Neurology. 2005 Jan 25; 64(2):361-3. PMID: 15668443.
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    146. Begovich AB, Caillier SJ, Alexander HC, Penko JM, Hauser SL, Barcellos LF, Oksenberg J. The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis. Am J Hum Genet. 2005 Jan; 76(1):184-7. PMID: 15580548; PMCID: PMC1196423.
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    148. Cree BA, Khan O, Bourdette D, Goodin DS, Cohen JA, Marrie RA, Glidden D, Weinstock-Guttman B, Reich D, Patterson N, Haines JL, Pericak-Vance M, DeLoa C, Oksenberg J, Hauser SL. Clinical characteristics of African Americans vs Caucasian Americans with multiple sclerosis. Neurology. 2004 Dec 14; 63(11):2039-45. PMID: 15596747.
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    149. Kenealy SJ, Babron MC, Bradford Y, Schnetz-Boutaud N, Haines JL, Rimmler JB, Schmidt S, Pericak-Vance MA, Barcellos LF, Lincoln RR, Oksenberg J, Hauser SL, Clanet M, Brassat D, Edan G, Yaouanq J, Semana G, Cournu-Rebeix I, Lyon-Caen O, Fontaine B. A second-generation genomic screen for multiple sclerosis. Am J Hum Genet. 2004 Dec; 75(6):1070-8. PMID: 15494893; PMCID: PMC1182142.
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    152. Barcellos LF, Begovich AB, Reynolds RL, Caillier SJ, Brassat D, Schmidt S, Grams SE, Walker K, Steiner LL, Cree BA, Stillman A, Lincoln RR, Pericak-Vance MA, Haines JL, Erlich HA, Hauser SL, Oksenberg J. Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. Ann Neurol. 2004 Jun; 55(6):793-800. PMID: 15174013.
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    153. Villoslada P, Oksenberg J, Rio J, Montalban X. Clinical characteristics of responders to interferon therapy for relapsing MS. Neurology. 2004 May 11; 62(9):1653; author reply 1653. PMID: 15136712.
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    154. Villoslada P, Barcellos LF, Oksenberg J. Chromosome 7q21-22 and multiple sclerosis. J Neuroimmunol. 2004 May; 150(1-2):1-2. PMID: 15081242.
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    155. Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg J, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ, Reich D. Methods for high-density admixture mapping of disease genes. Am J Hum Genet. 2004 May; 74(5):979-1000. PMID: 15088269; PMCID: PMC1181990.
    156. Mirel DB, Barcellos LF, Wang J, Hauser SL, Oksenberg J, Erlich HA. Analysis of IL4R haplotypes in predisposition to multiple sclerosis. Genes Immun. 2004 Mar; 5(2):138-41. PMID: 14712310.
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    157. Oksenberg J, Barcellos LF, Cree BA, Baranzini SE, Bugawan TL, Khan O, Lincoln RR, Swerdlin A, Mignot E, Lin L, Goodin D, Erlich HA, Schmidt S, Thomson G, Reich DE, Pericak-Vance MA, Haines JL, Hauser SL. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet. 2004 Jan; 74(1):160-7. PMID: 14669136; PMCID: PMC1181903.
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    159. Caillier S, Barcellos LF, Baranzini SE, Swerdlin A, Lincoln RR, Steinman L, Martin E, Haines JL, Pericak-Vance M, Hauser SL, Oksenberg J. Osteopontin polymorphisms and disease course in multiple sclerosis. Genes Immun. 2003 Jun; 4(4):312-5. PMID: 12761568.
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    160. Sriram U, Barcellos LF, Villoslada P, Rio J, Baranzini SE, Caillier S, Stillman A, Hauser SL, Montalban X, Oksenberg J. Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis. Genes Immun. 2003 Mar; 4(2):147-52. PMID: 12618863.
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    161. Barcellos LF, Oksenberg J, Begovich AB, Martin ER, Schmidt S, Vittinghoff E, Goodin DS, Pelletier D, Lincoln RR, Bucher P, Swerdlin A, Pericak-Vance MA, Haines JL, Hauser SL. HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am J Hum Genet. 2003 Mar; 72(3):710-6. PMID: 12557126; PMCID: PMC1180245.
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    163. Haukim N, Bidwell JL, Smith AJ, Keen LJ, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases, supplement 2. Genes Immun. 2002 Sep; 3(6):313-30. PMID: 12209358.
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    164. Villoslada P, Barcellos LF, Rio J, Begovich AB, Tintore M, Sastre-Garriga J, Baranzini SE, Casquero P, Hauser SL, Montalban X, Oksenberg J. The HLA locus and multiple sclerosis in Spain. Role in disease susceptibility, clinical course and response to interferon-beta. J Neuroimmunol. 2002 Sep; 130(1-2):194-201. PMID: 12225902.
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    165. Baranzini SE, Laxer K, Bollen A, Oksenberg J. Gene expression analysis reveals altered brain transcription of glutamate receptors and inflammatory genes in a patient with chronic focal (Rasmussen's) encephalitis. J Neuroimmunol. 2002 Jul; 128(1-2):9-15. PMID: 12098505.
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    166. Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, Langer-Gould A, Strober S, Cannella B, Allard J, Klonowski P, Austin A, Lad N, Kaminski N, Galli SJ, Oksenberg J, Raine CS, Heller R, Steinman L. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med. 2002 May; 8(5):500-8. PMID: 11984595.
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    167. Grams SE, Moonsamy PV, Mano C, Oksenberg J, Begovich AB. Two new HLA-B alleles, B*4422 and B*4704, identified in a study of families with autoimmunity. Tissue Antigens. 2002 Apr; 59(4):338-40. PMID: 12135438.
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    168. Steinman L, Martin R, Bernard C, Conlon P, Oksenberg J. Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy. Annu Rev Neurosci. 2002; 25:491-505. PMID: 12052918.
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    169. Baranzini SE, Laxer K, Saketkhoo R, Elkins MK, Parent JM, Mantegazza R, Oksenberg J. Analysis of antibody gene rearrangement, usage, and specificity in chronic focal encephalitis. Neurology. 2002 Mar 12; 58(5):709-16. PMID: 11889232.
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    170. Baranzini SE, Oksenberg J, Hauser SL. New insights into the genetics of multiple sclerosis. J Rehabil Res Dev. 2002 Mar-Apr; 39(2):201-9. PMID: 12051464.
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    173. Barcellos LF, Oksenberg J, Green AJ, Bucher P, Rimmler JB, Schmidt S, Garcia ME, Lincoln RR, Pericak-Vance MA, Haines JL, Hauser SL. Genetic basis for clinical expression in multiple sclerosis. Brain. 2002 Jan; 125(Pt 1):150-8. PMID: 11834600.
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    174. Chabas D, Baranzini SE, Mitchell D, Bernard CC, Rittling SR, Denhardt DT, Sobel RA, Lock C, Karpuj M, Pedotti R, Heller R, Oksenberg J, Steinman L. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science. 2001 Nov 23; 294(5547):1731-5. PMID: 11721059.
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    175. Pericak-Vance MA, Rimmler JB, Martin ER, Haines JL, Garcia ME, Oksenberg J, Barcellos LF, Lincoln R, Goodkin DE, Hauser SL. Linkage and association analysis of chromosome 19q13 in multiple sclerosis. Neurogenetics. 2001 Oct; 3(4):195-201. PMID: 11714099.
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    176. Barcellos LF, Caillier S, Dragone L, Elder M, Vittinghoff E, Bucher P, Lincoln RR, Pericak-Vance M, Haines JL, Weiss A, Hauser SL, Oksenberg J. PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. Nat Genet. 2001 Sep; 29(1):23-4. PMID: 11528386.
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    177. Green AJ, Bollen AW, Berger MS, Oksenberg J, Hauser SL. Multiple sclerosis and oligodendroglioma. Mult Scler. 2001 Aug; 7(4):269-73. PMID: 11548988.
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    178. Green AJ, Barcellos LF, Rimmler JB, Garcia ME, Caillier S, Lincoln RR, Bucher P, Pericak-Vance MA, Haines JL, Hauser SL, Oksenberg J. Sequence variation in the transforming growth factor-beta1 (TGFB1) gene and multiple sclerosis susceptibility. J Neuroimmunol. 2001 May 01; 116(1):116-24. PMID: 11311337.
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    179. Klitz W, Brautbar C, Schito AM, Barcellos LF, Oksenberg J. Evolution of the CCR5 Delta32 mutation based on haplotype variation in Jewish and Northern European population samples. Hum Immunol. 2001 May; 62(5):530-8. PMID: 11334678.
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    180. Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases, supplement 1. Genes Immun. 2001 Apr; 2(2):61-70. PMID: 11393658.
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    181. Oksenberg J, Baranzini SE, Barcellos LF, Hauser SL. Multiple sclerosis: genomic rewards. J Neuroimmunol. 2001 Feb 15; 113(2):171-84. PMID: 11164900.
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    182. Schito AM, Vittinghoff E, Hecht FM, Elkins MK, Kahn JO, Levy JA, Oksenberg J. Longitudinal analysis of T-cell receptor gene use by CD8(+) T cells in early human immunodeficiency virus infection in patients receiving highly active antiretroviral therapy. Blood. 2001 Jan 01; 97(1):214-20. PMID: 11133763.
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    183. Baranzini SE, Elfstrom C, Chang SY, Butunoi C, Murray R, Higuchi R, Oksenberg J. Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression. J Immunol. 2000 Dec 01; 165(11):6576-82. PMID: 11086101.
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    184. Hauser SL, Oksenberg J, Lincoln R, Garovoy J, Beck RW, Cole SR, Moke PS, Kip KE, Gal RL, Long DT. Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS. Optic Neuritis Study Group. Neurology. 2000 May 09; 54(9):1859-61. PMID: 10802800.
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    185. Oksenberg J, Barcellos LF. The complex genetic aetiology of multiple sclerosis. J Neurovirol. 2000 May; 6 Suppl 2:S10-4. PMID: 10871777.
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    186. Barcellos LF, Schito AM, Rimmler JB, Vittinghoff E, Shih A, Lincoln R, Callier S, Elkins MK, Goodkin DE, Haines JL, Pericak-Vance MA, Hauser SL, Oksenberg J. CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group. Immunogenetics. 2000 Apr; 51(4-5):281-8. PMID: 10803840.
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    187. Karni A, Kohn Y, Safirman C, Abramsky O, Barcellos L, Oksenberg J, Kahana E, Karussis D, Chapman J, Brautbar C. Evidence for the genetic role of human leukocyte antigens in low frequency DRB1*1501 multiple sclerosis patients in Israel. Mult Scler. 1999 Dec; 5(6):410-5. PMID: 10618697.
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    188. Lock C, Oksenberg J, Steinman L. The role of TNFalpha and lymphotoxin in demyelinating disease. Ann Rheum Dis. 1999 Nov; 58 Suppl 1:I121-8. PMID: 10577988; PMCID: PMC1766588.
    189. Baranzini SE, Jeong MC, Butunoi C, Murray RS, Bernard CC, Oksenberg J. B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J Immunol. 1999 Nov 01; 163(9):5133-44. PMID: 10528220.
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    190. Fontaine B, Cournu I, Arnaud I, Babron MC, Eichenbaum-Voline S, Oksenberg J, Pericak-Vance MA, Haines JL, Semama G, Liblau R, Lyon-Caen O, Clerget-Darpoux F, Clanet M, Hauser SL. Chromosome 17q22-q24 and multiple sclerosis genetic susceptibility. American-French Multiple Sclerosis Genetic Group. Genes Immun. 1999 Nov; 1(2):149-50. PMID: 11196661.
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    191. Seboun E, Oksenberg J, Rombos A, Usuku K, Goodkin DE, Lincoln RR, Wong M, Pham-Dinh D, Boesplug-Tanguy O, Carsique R, Fitoussi R, Gartioux C, Reyes C, Ribierre F, Faure S, Fizames C, Gyapay G, Weissenbach J, Dautigny A, Rimmler JB, Garcia ME, Pericak-Vance MA, Haines JL, Hauser SL. Linkage analysis of candidate myelin genes in familial multiple sclerosis. Neurogenetics. 1999 Sep; 2(3):155-62. PMID: 10541588.
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    192. Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases. Genes Immun. 1999 Sep; 1(1):3-19. PMID: 11197303.
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    193. Conlon P, Oksenberg J, Zhang J, Steinman L. The immunobiology of multiple sclerosis: an autoimmune disease of the central nervous system. Neurobiol Dis. 1999 Jun; 6(3):149-66. PMID: 10408805.
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    194. Oksenberg J, Barcellos LF, Hauser SL. Genetic aspects of multiple sclerosis. Semin Neurol. 1999; 19(3):281-8. PMID: 12194384.
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    195. Jeong MC, Izikson L, Uccelli A, Brocke S, Oksenberg J. Differential display analysis of murine encephalitogenic mRNA. Int Immunol. 1998 Dec; 10(12):1819-23. PMID: 9885902.
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    196. Haines JL, Terwedow HA, Burgess K, Pericak-Vance MA, Rimmler JB, Martin ER, Oksenberg J, Lincoln R, Zhang DY, Banatao DR, Gatto N, Goodkin DE, Hauser SL. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group. Hum Mol Genet. 1998 Aug; 7(8):1229-34. PMID: 9668163.
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    197. Diaz-Villoslada P, Oksenberg J. Chronic inflammatory diseases of the nervous system. Curr Opin Neurol. 1998 Jun; 11(3):235-40. PMID: 9642542.
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    198. Jeong MC, Navani A, Oksenberg J. Limited allelic polymorphism in the human interleukin-3 gene. Mol Cell Probes. 1998 Feb; 12(1):49-53. PMID: 9584078.
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    199. Oksenberg J, Stavri GT, Jeong MC, Garovoy N, Salisbury JR, Erusalimsky JD. Analysis of the T-cell receptor repertoire in human atherosclerosis. Cardiovasc Res. 1997 Nov; 36(2):256-67. PMID: 9463637.
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    200. Hvas J, McLean C, Justesen J, Kannourakis G, Steinman L, Oksenberg J, Bernard CC. Perivascular T cells express the pro-inflammatory chemokine RANTES mRNA in multiple sclerosis lesions. Scand J Immunol. 1997 Aug; 46(2):195-203. PMID: 9584001.
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    201. Oksenberg J, Hauser SL. New insights into the immunogenetics of multiple sclerosis. Curr Opin Neurol. 1997 Jun; 10(3):181-5. PMID: 9229123.
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    202. Karpuj MV, Steinman L, Oksenberg J. Multiple sclerosis: a polygenic disease involving epistatic interactions, germline rearrangements and environmental effects. Neurogenetics. 1997 May; 1(1):21-8. PMID: 10735270.
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    203. Li Y, Uccelli A, Laxer KD, Jeong MC, Vinters HV, Tourtellotte WW, Hauser SL, Oksenberg J. Local-clonal expansion of infiltrating T lymphocytes in chronic encephalitis of Rasmussen. J Immunol. 1997 Feb 01; 158(3):1428-37. PMID: 9013988.
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    204. Uccelli A, Oksenberg J, Jeong MC, Genain CP, Rombos T, Jaeger EE, Giunti D, Lanchbury JS, Hauser SL. Characterization of the TCRB chain repertoire in the New World monkey Callithrix jacchus. J Immunol. 1997 Feb 01; 158(3):1201-7. PMID: 9013960.
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    205. Leppert D, Waubant E, Bürk MR, Oksenberg J, Hauser SL. Interferon beta-1b inhibits gelatinase secretion and in vitro migration of human T cells: a possible mechanism for treatment efficacy in multiple sclerosis. Ann Neurol. 1996 Dec; 40(6):846-52. PMID: 9007089.
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    206. Oksenberg J. Immunogenetics and heterogeneity in multiple sclerosis. Ann Neurol. 1996 Oct; 40(4):557-8. PMID: 8871572.
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    207. Haines JL, Ter-Minassian M, Bazyk A, Gusella JF, Kim DJ, Terwedow H, Pericak-Vance MA, Rimmler JB, Haynes CS, Roses AD, Lee A, Shaner B, Menold M, Seboun E, Fitoussi RP, Gartioux C, Reyes C, Ribierre F, Gyapay G, Weissenbach J, Hauser SL, Goodkin DE, Lincoln R, Usuku K, Oksenberg J. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group. Nat Genet. 1996 Aug; 13(4):469-71. PMID: 8696344.
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    208. Waisman A, Ruiz PJ, Hirschberg DL, Gelman A, Oksenberg J, Brocke S, Mor F, Cohen IR, Steinman L. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat Med. 1996 Aug; 2(8):899-905. PMID: 8705860.
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    209. Oksenberg J, Seboun E, Hauser SL. Genetics of demyelinating diseases. Brain Pathol. 1996 Jul; 6(3):289-302. PMID: 8864285.
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    210. Szafer F, Price VH, Oksenberg J, Steinman L. T-cell receptor repertoire V beta in alopecia areata. J Invest Dermatol. 1995 May; 104(5 Suppl):22S-24S. PMID: 7738379.
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    211. Oksenberg J. Selective targeting of the immune response in autoimmune demyelination. West J Med. 1994 Sep; 161(3):255-9. PMID: 7975563; PMCID: PMC1011406.
    212. Szafer F, Oksenberg J, Steinman L. New allelic polymorphisms in TAP genes. Immunogenetics. 1994; 39(5):374. PMID: 8168860.
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    213. Steinman L, Miller A, Bernard CC, Oksenberg J. The epigenetics of multiple sclerosis: clues to etiology and a rationale for immune therapy. Annu Rev Neurosci. 1994; 17:247-65. PMID: 8210175.
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    214. Oksenberg J, Begovich AB, Erlich HA, Steinman L. Genetic factors in multiple sclerosis. JAMA. 1993 Nov 17; 270(19):2362-9. PMID: 8230601.
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    215. Struyk L, Kurnick JT, Hawes GE, van Laar JM, Schipper R, Oksenberg J, Steinman L, de Vries RR, Breedveld FC, van den Elsen P. T-cell receptor V-gene usage in synovial fluid lymphocytes of patients with chronic arthritis. Hum Immunol. 1993 Aug; 37(4):237-51. PMID: 8300409.
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    216. Kan-Mitchell J, Huang XQ, Steinman L, Oksenberg J, Harel W, Parker JW, Goedegebuure PS, Darrow TL, Mitchell MS. Clonal analysis of in vivo activated CD8+ cytotoxic T lymphocytes from a melanoma patient responsive to active specific immunotherapy. Cancer Immunol Immunother. 1993 Jul; 37(1):15-25. PMID: 8513449.
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    217. Hvas J, Oksenberg J, Fernando R, Steinman L, Bernard CC. Gamma delta T cell receptor repertoire in brain lesions of patients with multiple sclerosis. J Neuroimmunol. 1993 Jul; 46(1-2):225-34. PMID: 8395544.
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    218. Melms A, Oksenberg J, Malcherek G, Schoepfer R, Müller CA, Lindstrom J, Steinman L. T-cell receptor gene usage of acetylcholine receptor-specific T-helper cells. Ann N Y Acad Sci. 1993 Jun 21; 681:313-4. PMID: 8357179.
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    219. Mantegazza R, Andreetta F, Bernasconi P, Baggi F, Oksenberg J, Simoncini O, Mora M, Cornelio F, Steinman L. Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis. Restricted V alpha/beta rearrangements may indicate antigen-driven selection. J Clin Invest. 1993 Jun; 91(6):2880-6. PMID: 8514895; PMCID: PMC443358.
    220. Oksenberg J, Panzara MA, Steinman L. Multiple sclerosis: from immunogenetics to immunotherapy. J Neurol Sci. 1993 Apr; 115 Suppl:S29-37. PMID: 8340790.
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    221. Oksenberg J, Panzara MA, Begovich AB, Mitchell D, Erlich HA, Murray RS, Shimonkevitz R, Sherritt M, Rothbard J, Bernard CC. Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature. 1993 Mar 04; 362(6415):68-70. PMID: 7680433.
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    222. Panzara MA, Gussoni E, Steinman L, Oksenberg J. Analysis of the T cell repertoire using the PCR and specific oligonucleotide primers. Biotechniques. 1992 May; 12(5):728-35. PMID: 1515141.
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    223. De Magistris MT, Di Tommaso A, Domenighini M, Censini S, Tagliabue A, Oksenberg J, Steinman L, Judd AK, O'Sullivan D, Rappuoli R. Interaction of the pertussis toxin peptide containing residues 30-42 with DR1 and the T-cell receptors of 12 human T-cell clones. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2990-4. PMID: 1313575; PMCID: PMC48789.
    224. Panzara MA, Oksenberg J, Steinman L. The polymerase chain reaction for detection of T-cell antigen receptor expression. Curr Opin Immunol. 1992 Apr; 4(2):205-10. PMID: 1605910.
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    225. Bucht A, Oksenberg J, Lindblad S, Grönberg A, Steinman L, Klareskog L. Characterization of T-cell receptor alpha beta repertoire in synovial tissue from different temporal phases of rheumatoid arthritis. Scand J Immunol. 1992 Feb; 35(2):159-65. PMID: 1531390.
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    226. Sherritt MA, Oksenberg J, de Rosbo NK, Bernard CC. Influence of HLA-DR2, HLA-DPw4, and T cell receptor alpha chain genes on the susceptibility to multiple sclerosis. Int Immunol. 1992 Feb; 4(2):177-81. PMID: 1352460.
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    227. Steinman L, Oksenberg J, Bernard CC. Association of susceptibility to multiple sclerosis with TCR genes. Immunol Today. 1992 Feb; 13(2):49-51. PMID: 1533525.
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    228. Steinman L, Oksenberg J, Bernard CA. Polymorphism in MS. Neurology. 1992 Feb; 42(2):466-7. PMID: 1346550.
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    229. Bahler DW, Berry G, Oksenberg J, Warnke RA, Levy R. Diversity of T-cell antigen receptor variable genes used by mycosis fungoides cells. Am J Pathol. 1992 Jan; 140(1):1-8. PMID: 1731519; PMCID: PMC1886256.
    230. Oksenberg J, Steinman L. New approaches to the therapy of demyelinating disease. Curr Opin Neurobiol. 1991 Oct; 1(3):436-40. PMID: 1821688.
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    231. Oksenberg J, Stuart S, Begovich AB, Bell RB, Erlich HA, Steinman L, Bernard CC. Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature. 1991 Sep 05; 353(6339):94. PMID: 1652695.
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    232. Kan-Mitchell J, Liggett PE, Harel W, Steinman L, Nitta T, Oksenberg J, Posner MR, Mitchell MS. Lymphocytes cytotoxic to uveal and skin melanoma cells from peripheral blood of ocular melanoma patients. Cancer Immunol Immunother. 1991; 33(5):333-40. PMID: 1831067.
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    233. Oksenberg J, Mantegazza R, Sakai K, Bernard CC, Steinman L. HTLV-I sequences are not detected in peripheral blood genomic DNA or in brain cDNA of multiple sclerosis patients. Ann Neurol. 1990 Oct; 28(4):574-7. PMID: 2252368.
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    234. Nitta T, Oksenberg J, Rao NA, Steinman L. Predominant expression of T cell receptor V alpha 7 in tumor-infiltrating lymphocytes of uveal melanoma. Science. 1990 Aug 10; 249(4969):672-4. PMID: 2382141.
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    235. Mantegazza R, Oksenberg J, Baggi F, Antozzi C, Illeni MT, Pellegris G, Cornelio F, Steinman L. Increased incidence of certain TCR and HLA genes associated with myasthenia gravis in Italians. J Autoimmun. 1990 Aug; 3(4):431-40. PMID: 1977403.
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    236. Begovich AB, Helmuth RC, Oksenberg J, Sakai K, Tabira T, Sasazuki T, Steinman L, Erlich HA. HLA-DP beta and susceptibility to multiple sclerosis: an analysis of caucasoid and Japanese patient populations. Hum Immunol. 1990 Aug; 28(4):365-72. PMID: 2391251.
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    237. Oksenberg J, Stuart S, Begovich AB, Bell RB, Erlich HA, Steinman L, Bernard CC. Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature. 1990 May 24; 345(6273):344-6. PMID: 1971424.
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    238. Oksenberg J, Ko C, Judd AK, Lim M, Kent A, Schoolnik GK, Steinman L. Multiple T and B cell epitopes in the S1 subunit ("A"-monomer) of the pertussis toxin molecule. J Immunol. 1989 Dec 15; 143(12):4227-31. PMID: 2480389.
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    239. Oksenberg D, Oksenberg J, Sakai K, Peroutka SJ, Steinman L. Cyclic adenosine 3',5'-monophosphate metabolism in activated T-cell clones. Immunology. 1989 Aug; 67(4):484-8. PMID: 2475434; PMCID: PMC1385318.
    240. Oksenberg J, Sherritt M, Begovich AB, Erlich HA, Bernard CC, Cavalli-Sforza LL, Steinman L. T-cell receptor V alpha and C alpha alleles associated with multiple and myasthenia gravis. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):988-92. PMID: 2915992; PMCID: PMC286604.
    241. Oksenberg J, Steinman L. The role of the MHC and T-cell receptor in susceptibility to multiple sclerosis. Curr Opin Immunol. 1989-1990 Apr; 2(4):619-21. PMID: 2700905.
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    242. Oksenberg J, Judd AK, Ko C, Lim M, Fernandez R, Schoolnik GK, Steinman L. MHC-restricted recognition of immunogenic T cell epitopes of pertussis toxin reveals determinants in man distinct from the ADP-ribosylase active site. J Exp Med. 1988 Nov 01; 168(5):1855-64. PMID: 2460578; PMCID: PMC2189123.
    243. Oksenberg J, Gaiser CN, Cavalli-Sforza LL, Steinman L. Polymorphic markers of human T-cell receptor alpha and beta genes. Family studies and comparison of frequencies in healthy individuals and patients with multiple sclerosis and myasthenia gravis. Hum Immunol. 1988 Jun; 22(2):111-21. PMID: 2971027.
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    244. Oksenberg J, Mor-Yosef S, Ezra Y, Brautbar C. Antigen presenting cells in human decidual tissue: III. Role of accessory cells in the activation of suppressor cells. Am J Reprod Immunol Microbiol. 1988 Apr; 16(4):151-8. PMID: 2971325.
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    245. Oksenberg J, Mor-Yosef S, Ezra Y, Brauthbar C. Antigen presenting cells in human decidual tissue. II: Accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes. J Reprod Immunol. 1987 Apr; 10(4):309-18. PMID: 3498029.
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    246. Bishara A, Oksenberg J, Frankel G, Margalioth EI, Persitz E, Nelken D, Friedmann A, Brautbar C. Human leukocyte antigens (HLA) class I and class II on sperm cells studied at the serological, cellular, and genomic levels. Am J Reprod Immunol Microbiol. 1987 Apr; 13(4):97-103. PMID: 2440323.
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    247. Oksenberg J, Brautbar C. In vitro suppression of murine blastocysts growth by sera from women with reproductive disorders. Am J Reprod Immunol Microbiol. 1986 Aug; 11(4):118-24. PMID: 2945446.
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    248. Oksenberg J, Mor-Yosef S, Persitz E, Schenker Y, Mozes E, Brautbar C. Antigen-presenting cells in human decidual tissue. Am J Reprod Immunol Microbiol. 1986 Jul; 11(3):82-8. PMID: 2944402.
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    249. Persitz E, Oksenberg J, Brautbar C. [The HLA system and habitual spontaneous abortions]. Harefuah. 1986 Jan 01; 110(1):33-6. PMID: 2937699.
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    250. Oksenberg J, Persitz E, Brautbar C. Cellular immunity in human milk. Am J Reprod Immunol Microbiol. 1985 Aug; 8(4):125-9. PMID: 2931033.
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    251. Persitz E, Oksenberg J, Margalioth EJ, Hacohen S, Schenker J, Brautbar C. Histoincompatibility in couples with unexplained infertility. Fertil Steril. 1985 May; 43(5):733-8. PMID: 3158547.
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    252. Oksenberg J, Persitz E, Amar A, Brautbar C. Maternal-paternal histocompatibility: lack of association with habitual abortions. Fertil Steril. 1984 Sep; 42(3):389-95. PMID: 6236105.
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    253. Cohen N, Shaw S, Amar A, Oksenberg J, Brautbar C. HLA-linked SB antigens in Israel. Population study, analysis of homozygous typing cells and generation of local SB reagents. Tissue Antigens. 1984 Aug; 24(2):113-20. PMID: 6593897.
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    254. Cohen N, Amar A, Oksenberg J, Brautbar C. HLA-D clusters associated with DR2 and the definition of HLA-D"AZH": a new DR2 related HLA-D specificity in Israel. Tissue Antigens. 1984 Jul; 24(1):1-9. PMID: 6207623.
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    255. Oksenberg J, Amar A, Cohen N, Grosse-Wilde H, Cohen I, Sharon R, Nelken D, Brautbar C. HLA-D "BG" in Israel. A Japanese related allele population and family study. Tissue Antigens. 1983 Apr; 21(4):271-80. PMID: 6407145.
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    256. Oksenberg J, Persitz E, Amar A, Schenker J, Segal S, Nelken D, Brautbar C. Mixed lymphocyte reactivity nonresponsiveness in couples with multiple spontaneous abortions. Fertil Steril. 1983 Apr; 39(4):525-9. PMID: 6219899.
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    257. Persitz E, Oksenberg J, Amar A, Margalioth EJ, Cohen O, Brautbar C. Histocompatibility antigens, mixed lymphocyte reactivity and severe preeclampsia in Israel. Gynecol Obstet Invest. 1983; 16(5):283-91. PMID: 6227533.
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    258. Amar A, Oksenberg J, Cohen N, Cohen I, Brautbar C. HLA-D locus in Israel. Characterization of 14 local HTC's and a population study. Tissue Antigens. 1982 Sep; 20(3):198-207. PMID: 6215743.
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    259. Brautbar C, Amar A, Cohen N, Oksenberg J, Cohen I, Kahana E, Bloch D, Alter M, Grosse-Wilde H. HLA-D typing in multiple sclerosis: Israelis tested with European homozygous typing cells. Tissue Antigens. 1982 Mar; 19(3):189-97. PMID: 6953617.
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    260. Oksenberg J, Amar A, Cohen N, Cohen T, Brautbar C. HLA-DR, D recombination in a kidney transplant recipient. Hum Immunol. 1982 Feb; 4(1):47-53. PMID: 6460723.
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    261. Oksenberg J. [Some aspects of the venous blood supply of the parotid gland]. Odontol Chil. 1973 Jan-Mar; 21(108):12-3. PMID: 4524679.
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    262. Oksenberg J. [Venous circulation of the face]. Odontol Chil. 1972 Jul-Sep; 20(106):27-8. PMID: 4515355.
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    263. Oksenberg J, Triantafilo P. [Anatomical and clinico-surgical aspects of the malar region]. Odontol Chil. 1972 Jan-Mar; 20(104):15-21. PMID: 4512853.
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