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Jorge Oksenberg, PhD

Title(s)Professor, Neurology
SchoolSchool of Medicine
Phone415-476-1335
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    Collapse Biography 
    Collapse Awards and Honors
    VA Multiple Sclerosis Center of Excellence 2009The John N. Whitaker Memorial Lecture
    UCSF2005G.A. Zimmermann Endowed Chair in Neurology

    Collapse Overview 
    Collapse Overview
    Immune-mediated neurological impairment is the outcome of a rather extensive and coordinated series of events that include peripheral lymphocyte activation, disruption of the blood-brain barrier, cellular infiltration into the brain parenchyma, local inflammation and tissue injury. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules (including free radicals, proteases, vasoactive amines, and excitatory neurotransmitters) induce and regulate numerous critical cell functions that perpetuate inflammation, leading to tissue injury, neuro-degeneration, and neurological deficits. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extend conditioned by the unique amino acid sequences that define allelic variants on each of the participating molecules. Genes, either in their germline configuration and/or as part of complex functional networks, play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy.

    The principal aim of our laboratory (see link below) is to identify the major genetic factors that predispose to autoimmunity in the central nervous system and modulate disease presentation and progression. The availability of highly sensitive and high-capacity methods for analysis of gene variation and expression combined with the implementation of algorithms that predict behaviors in complex biological circuits provides an outstanding opportunity to facilitate progress in the integration of multiple data sources and functional interpretation of physiological and laboratory results. Our goal is to apply novel molecular, informatic, statistical, and epidemiological approaches to illuminate fully the genetics of autoimmune demyelination. Specifically, our research plan includes:
    • Genome wide gene/haplotype mapping for the discovery of MS genes
    • Genotype-phenotype correlations in MS
    • Gene-environment correlations in MS
    • Genomic and clinical study of MS populations at low and intermediate risk
    • MS pharmacogenomics
    • Gene expression networks in human and experimental neuroinflammation

    Collapse Research 
    Collapse Research Activities and Funding
    MHC variation at high resolution in multiple sclerosis
    NIH/NINDS R01NS102153Aug 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Immunogenetic Determinants of Disease Risk in Neurological Disease
    NIH/NINDS U19NS095774Jul 1, 2015 - Jul 31, 2020
    Role: Principal Investigator
    The contribution of common and rare variants to autoimmunity in African Americans
    NIH/NINDS R01NS076492Aug 15, 2011 - Apr 30, 2015
    Role: Principal Investigator
    Immunogenetic Studies in Multiple Sclerosis
    NIH/NINDS R01NS046297Jul 16, 2003 - Dec 31, 2014
    Role: Principal Investigator
    Immunomodulation in Multiple Sclerosis by Interferon B
    NIH/NINDS R01NS042911Sep 30, 2002 - Aug 31, 2007
    Role: Principal Investigator
    IMMUNOLOGICAL BASIS OF EPILEPSY
    NIH/NINDS R01NS035761Jun 16, 1997 - May 31, 2001
    Role: Principal Investigator
    Gene linkage study of multiple sclerosis sibling pairs
    NIH/NINDS R01NS026799Dec 1, 1988 - Jul 31, 2019
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Silent Progression in Disease Activity-Free Relapsing Multiple Sclerosis. Ann Neurol. 2019 Mar 09. PMID: 30851128.
      View in: PubMed
    2. Onengut-Gumuscu S, Chen WM, Robertson CC, Bonnie JK, Farber E, Zhu Z, Oksenberg JR, Brant SR, Bridges SL, Edberg JC, Kimberly RP, Gregersen PK, Rewers MJ, Steck AK, Black MH, Dabelea D, Pihoker C, Atkinson MA, Wagenknecht LE, Divers J, Bell RA, Erlich HA, Concannon P, Rich SS. Type 1 Diabetes Risk in African-Ancestry Participants and Utility of an Ancestry-Specific Genetic Risk Score. Diabetes Care. 2019 Jan 18. PMID: 30659077.
      View in: PubMed
    3. Misra MK, Augusto DG, Martin GM, Nemat-Gorgani N, Sauter J, Hofmann JA, Traherne JA, González-Quezada B, Gorodezky C, Bultitude WP, Marin W, Vierra-Green C, Anderson KM, Balas A, Caro-Oleas JL, Cisneros E, Colucci F, Dandekar R, Elfishawi SM, Fernández-Viña MA, Fouda M, González-Fernández R, Große A, Herrero-Mata MJ, Hollenbach SQ, Marsh SGE, Mentzer A, Middleton D, Moffett A, Moreno-Hidalgo MA, Mossallam GI, Nakimuli A, Oksenberg JR, Oppenheimer SJ, Parham P, Petzl-Erler ML, Planelles D, Sánchez-García F, Sánchez-Gordo F, Schmidt AH, Trowsdale J, Vargas LB, Vicario JL, Vilches C, Norman PJ, Hollenbach JA. Report from the Killer-cell Immunoglobulin-like Receptors (KIR) component of the 17th International HLA and Immunogenetics Workshop. Hum Immunol. 2018 Dec; 79(12):825-833. PMID: 30321631.
      View in: PubMed
    4. Amezcua L, Beecham AH, Delgado SR, Chinea A, Burnett M, Manrique CP, Gomez R, Comabella M, Montalban X, Ortega M, Tornes L, Lund BT, Islam T, Conti D, Oksenberg JR, McCauley JL. Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis. Ann Clin Transl Neurol. 2018 Nov; 5(11):1362-1371. PMID: 30480030.
      View in: PubMed
    5. Gil-Varea E, Urcelay E, Vilariño-Güell C, Costa C, Midaglia L, Matesanz F, Rodríguez-Antigüedad A, Oksenberg J, Espino-Paisan L, Dessa Sadovnick A, Saiz A, Villar LM, García-Merino JA, Ramió-Torrentà L, Triviño JC, Quintana E, Robles R, Sánchez-López A, Arroyo R, Alvarez-Cermeño JC, Vidal-Jordana A, Malhotra S, Fissolo N, Montalban X, Comabella M. Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course. J Neuroinflammation. 2018 Sep 14; 15(1):265. PMID: 30217166.
      View in: PubMed
    6. Regev K, Healy BC, Paul A, Diaz-Cruz C, Mazzola MA, Raheja R, Glanz BI, Kivisäkk P, Chitnis T, Jagodic M, Piehl F, Olsson T, Khademi M, Hauser S, Oksenberg J, Khoury SJ, Weiner HL, Gandhi R. Identification of MS-specific serum miRNAs in an international multicenter study. Neurol Neuroimmunol Neuroinflamm. 2018 Sep; 5(5):e491. PMID: 30175165.
      View in: PubMed
    7. Jia X, Madireddy L, Caillier S, Santaniello A, Esposito F, Comi G, Stuve O, Zhou Y, Taylor B, Kilpatrick T, Martinelli-Boneschi F, Cree BAC, Oksenberg JR, Hauser SL, Baranzini SE. Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis. Ann Neurol. 2018 Jul; 84(1):51-63. PMID: 29908077.
      View in: PubMed
    8. Mack SJ, Udell J, Cohen F, Osoegawa K, Hawbecker SK, Noonan DA, Ladner MB, Goodridge D, Trachtenberg EA, Oksenberg JR, Erlich HA. Correction: High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis. Genes Immun. 2018 Jun 18. PMID: 29915315.
      View in: PubMed
    9. Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L. Correction: Peroxisome proliferator-activated receptor (PPAR)a expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. J Exp Med. 2018 Jun 04; 215(6):1765. PMID: 29773642.
      View in: PubMed
    10. Creary LE, Mallempati KC, Gangavarapu S, Caillier SJ, Oksenberg JR, Fernández-Vina MA. Deconstruction of HLA-DRB1*04:01:01 and HLA-DRB1*15:01:01 class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosis. Mult Scler. 2018 Apr 01; 1352458518770019. PMID: 29683085.
      View in: PubMed
    11. Canto E, Isobe N, Didonna A, Hauser SL, Oksenberg JR. Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. J Neuroinflammation. 2018 Mar 07; 15(1):72. PMID: 29514694.
      View in: PubMed
    12. Mack SJ, Udell J, Cohen F, Osoegawa K, Hawbecker SK, Noonan DA, Ladner MB, Goodridge D, Trachtenberg EA, Oksenberg JR, Erlich HA. High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis. Genes Immun. 2018 Jan 08. PMID: 29307888.
      View in: PubMed
    13. Canto E, Oksenberg JR. Multiple sclerosis genetics. Mult Scler. 2018 Jan; 24(1):75-79. PMID: 29307290.
      View in: PubMed
    14. Graves JS, Henry RG, Cree BAC, Lambert-Messerlian G, Greenblatt RM, Waubant E, Cedars MI, Zhu A, Bacchetti P, Hauser SL, Oksenberg JR. Ovarian aging is associated with gray matter volume and disability in women with MS. Neurology. 2018 Jan 16; 90(3):e254-e260. PMID: 29273686.
      View in: PubMed
    15. Baranzini SE, Oksenberg JR. The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years. Trends Genet. 2017 12; 33(12):960-970. PMID: 28987266.
      View in: PubMed
    16. Amezcua L, Oksenberg JR, McCauley JL. MS in self-identified Hispanic/Latino individuals living in the US. Mult Scler J Exp Transl Clin. 2017 Jul-Sep; 3(3):2055217317725103. PMID: 28979795.
      View in: PubMed
    17. Benedek G, Meza-Romero R, Jordan K, Zhang Y, Nguyen H, Kent G, Li J, Siu E, Frazer J, Piecychna M, Du X, Sreih A, Leng L, Wiedrick J, Caillier SJ, Offner H, Oksenberg JR, Yadav V, Bourdette D, Bucala R, Vandenbark AA. MIF and D-DT are potential disease severity modifiers in male MS subjects. Proc Natl Acad Sci U S A. 2017 10 03; 114(40):E8421-E8429. PMID: 28923927.
      View in: PubMed
    18. Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI, Cardiel MH, Catoggio L, Cervera R, Cucho-Venegas JM, Dahlqvist SR, D'Alfonso S, Da Silva BM, de la Rúa Figueroa I, Doria A, Edberg JC, Endreffy E, Esquivel-Valerio JA, Fortin PR, Freedman BI, Frostegård J, García MA, de la Torre IG, Gilkeson GS, Gladman DD, Gunnarsson I, Guthridge JM, Huggins JL, James JA, Kallenberg CGM, Kamen DL, Karp DR, Kaufman KM, Kottyan LC, Kovács L, Laustrup H, Lauwerys BR, Li QZ, Maradiaga-Ceceña MA, Martín J, McCune JM, McWilliams DR, Merrill JT, Miranda P, Moctezuma JF, Nath SK, Niewold TB, Orozco L, Ortego-Centeno N, Petri M, Pineau CA, Pons-Estel BA, Pope J, Raj P, Ramsey-Goldman R, Reveille JD, Russell LP, Sabio JM, Aguilar-Salinas CA, Scherbarth HR, Scorza R, Seldin MF, Sjöwall C, Svenungsson E, Thompson SD, Toloza SMA, Truedsson L, Tusié-Luna T, Vasconcelos C, Vilá LM, Wallace DJ, Weisman MH, Wither JE, Bhangale T, Oksenberg JR, Rioux JD, Gregersen PK, Syvänen AC, Rönnblom L, Criswell LA, Jacob CO, Sivils KL, Tsao BP, Schanberg LE, Behrens TW, Silverman ED, Alarcón-Riquelme ME, Kimberly RP, Harley JB, Wakeland EK, Graham RR, Gaffney PM, Vyse TJ. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun. 2017 07 17; 8:16021. PMID: 28714469.
      View in: PubMed
    19. Isobe N, Oksenberg JR, Henry RG. HLA Genetic Risk Burden in Multiple Sclerosis-Reply. JAMA Neurol. 2016 12 01; 73(12):1501-1502. PMID: 27775754.
      View in: PubMed
    20. Vigo T, Procaccini C, Ferrara G, Baranzini S, Oksenberg JR, Matarese G, Diaspro A, Kerlero de Rosbo N, Uccelli A. IFN-? orchestrates mesenchymal stem cell plasticity through the signal transducer and activator of transcription 1 and 3 and mammalian target of rapamycin pathways. J Allergy Clin Immunol. 2017 May; 139(5):1667-1676. PMID: 27670240.
      View in: PubMed
    21. Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 08 22; 6:31603. PMID: 27546286.
      View in: PubMed
    22. Cree BA, Gourraud PA, Oksenberg JR, Bevan C, Crabtree-Hartman E, Gelfand JM, Goodin DS, Graves J, Green AJ, Mowry E, Okuda DT, Pelletier D, von Büdingen HC, Zamvil SS, Agrawal A, Caillier S, Ciocca C, Gomez R, Kanner R, Lincoln R, Lizee A, Qualley P, Santaniello A, Suleiman L, Bucci M, Panara V, Papinutto N, Stern WA, Zhu AH, Cutter GR, Baranzini S, Henry RG, Hauser SL. Long-term evolution of multiple sclerosis disability in the treatment era. Ann Neurol. 2016 10; 80(4):499-510. PMID: 27464262.
      View in: PubMed
    23. Norman PJ, Hollenbach JA, Nemat-Gorgani N, Marin WM, Norberg SJ, Ashouri E, Jayaraman J, Wroblewski EE, Trowsdale J, Rajalingam R, Oksenberg JR, Chiaroni J, Guethlein LA, Traherne JA, Ronaghi M, Parham P. Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing. Am J Hum Genet. 2016 Aug 04; 99(2):375-91. PMID: 27486779; PMCID: PMC4974113 [Available on 02/04/17].
    24. George MF, Briggs FB, Shao X, Gianfrancesco MA, Kockum I, Harbo HF, Celius EG, Bos SD, Hedström A, Shen L, Bernstein A, Alfredsson L, Hillert J, Olsson T, Patsopoulos NA, De Jager PL, Oturai AB, Søndergaard HB, Sellebjerg F, Sorensen PS, Gomez R, Caillier SJ, Cree BA, Oksenberg JR, Hauser SL, D'Alfonso S, Leone MA, Martinelli Boneschi F, Sorosina M, van der Mei I, Taylor BV, Zhou Y, Schaefer C, Barcellos LF. Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies. Neurol Genet. 2016 Aug; 2(4):e87. PMID: 27540591; PMCID: PMC4974846.
    25. Isobe N, Keshavan A, Gourraud PA, Zhu AH, Datta E, Schlaeger R, Caillier SJ, Santaniello A, Lizée A, Himmelstein DS, Baranzini SE, Hollenbach J, Cree BA, Hauser SL, Oksenberg JR, Henry RG. Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis. JAMA Neurol. 2016 07 01; 73(7):795-802. PMID: 27244296.
      View in: PubMed
    26. Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D'Alfonso S, Demaerel P, Dubois B, Filippi M, Fleischer V, Fontaine B, Gaetano L, Goris A, Graetz C, Gröger A, Groppa S, Hafler DA, Harbo HF, Hemmer B, Jordan K, Kappos L, Kirkish G, Llufriu S, Magon S, Martinelli-Boneschi F, McCauley JL, Montalban X, Mühlau M, Pelletier D, Pattany PM, Pericak-Vance M, Cournu-Rebeix I, Rocca MA, Rovira A, Schlaeger R, Saiz A, Sprenger T, Stecco A, Uitdehaag BMJ, Villoslada P, Wattjes MP, Weiner H, Wuerfel J, Zimmer C, Zipp F, Hauser SL, Oksenberg JR, Henry RG. Power estimation for non-standardized multisite studies. Neuroimage. 2016 07 01; 134:281-294. PMID: 27039700.
      View in: PubMed
    27. Khankhanian P, Cozen W, Himmelstein DS, Madireddy L, Din L, van den Berg A, Matsushita T, Glaser SL, Moré JM, Smedby KE, Baranzini SE, Mack TM, Lizée A, de Sanjosé S, Gourraud PA, Nieters A, Hauser SL, Cocco P, Maynadié M, Foretová L, Staines A, Delahaye-Sourdeix M, Li D, Bhatia S, Melbye M, Onel K, Jarrett R, McKay JD, Oksenberg JR, Hjalgrim H. Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis. Int J Epidemiol. 2016 06; 45(3):728-40. PMID: 26971321; PMCID: PMC5005944.
    28. Hollenbach JA, Pando MJ, Caillier SJ, Gourraud PA, Oksenberg JR. The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans. Genes Immun. 2016 04; 17(3):199-202. PMID: 26866467.
      View in: PubMed
    29. Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg JR. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8. PMID: 26433934; PMCID: PMC5007634 [Available on 12/15/16].
    30. Bustamante MF, Morcillo-Suárez C, Malhotra S, Rio J, Leyva L, Fernández O, Zettl UK, Killestein J, Brassat D, García-Merino JA, Sánchez AJ, Urcelay E, Alvarez-Lafuente R, Villar LM, Alvarez-Cermeño JC, Farré X, Lechner-Scott J, Vandenbroeck K, Rodríguez-Antigüedad A, Drulovic JS, Martinelli Boneschi F, Chan A, Oksenberg J, Navarro A, Montalban X, Comabella M. Pharmacogenomic study in patients with multiple sclerosis: Responders and nonresponders to IFN-ß. Neurol Neuroimmunol Neuroinflamm. 2015 Oct; 2(5):e154. PMID: 26445728; PMCID: PMC4582905.
    31. Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M, Shah TS, Patsopoulos NA, Alfredsson L, Anderson CA, Attfield KE, Baranzini SE, Barrett J, Binder TMC, Booth D, Buck D, Celius EG, Cotsapas C, D'Alfonso S, Dendrou CA, Donnelly P, Dubois B, Fontaine B, Fugger L, Goris A, Gourraud PA, Graetz C, Hemmer B, Hillert J, Kockum I, Leslie S, Lill CM, Martinelli-Boneschi F, Oksenberg JR, Olsson T, Oturai A, Saarela J, Søndergaard HB, Spurkland A, Taylor B, Winkelmann J, Zipp F, Haines JL, Pericak-Vance MA, Spencer CCA, Stewart G, Hafler DA, Ivinson AJ, Harbo HF, Hauser SL, De Jager PL, Compston A, McCauley JL, Sawcer S, McVean G. Class II HLA interactions modulate genetic risk for multiple sclerosis. Nat Genet. 2015 Oct; 47(10):1107-1113. PMID: 26343388.
      View in: PubMed
    32. Khankhanian P, Matsushita T, Madireddy L, Lizée A, Din L, Moré JM, Gourraud PA, Hauser SL, Baranzini SE, Oksenberg JR. Genetic contribution to multiple sclerosis risk among Ashkenazi Jews. BMC Med Genet. 2015 Jul 28; 16:55. PMID: 26212423; PMCID: PMC4557862.
    33. Hollenbach JA, Oksenberg JR. The immunogenetics of multiple sclerosis: A comprehensive review. J Autoimmun. 2015 Nov; 64:13-25. PMID: 26142251; PMCID: PMC4687745 [Available on 11/01/16].
    34. Tranah GJ, Santaniello A, Caillier SJ, D'Alfonso S, Martinelli Boneschi F, Hauser SL, Oksenberg JR. Mitochondrial DNA sequence variation in multiple sclerosis. Neurology. 2015 Jul 28; 85(4):325-30. PMID: 26136518; PMCID: PMC4520811.
    35. Isobe N, Madireddy L, Khankhanian P, Matsushita T, Caillier SJ, Moré JM, Gourraud PA, McCauley JL, Beecham AH, Piccio L, Herbert J, Khan O, Cohen J, Stone L, Santaniello A, Cree BA, Onengut-Gumuscu S, Rich SS, Hauser SL, Sawcer S, Oksenberg JR. An ImmunoChip study of multiple sclerosis risk in African Americans. Brain. 2015 Jun; 138(Pt 6):1518-30. PMID: 25818868; PMCID: PMC4553906.
    36. Matsushita T, Madireddy L, Sprenger T, Khankhanian P, Magon S, Naegelin Y, Caverzasi E, Lindberg RL, Kappos L, Hauser SL, Oksenberg JR, Henry R, Pelletier D, Baranzini SE. Genetic associations with brain cortical thickness in multiple sclerosis. Genes Brain Behav. 2015 Feb; 14(2):217-27. PMID: 25684059; PMCID: PMC4857705.
    37. Didonna A, Oksenberg JR. Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta. 2015 Sep 20; 449:16-22. PMID: 25661088; PMCID: PMC4524789 [Available on 09/20/16].
    38. Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Annese V, Hauser SL, Oksenberg JR, Thomsen I, Leslie S, Daly MJ, Van Steen K, Duerr RH, Barrett JC, McGovern DP, Schumm LP, Traherne JA, Carrington MN, Kosmoliaptsis V, Karlsen TH, Franke A, Rioux JD. High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat Genet. 2015 Feb; 47(2):172-9. PMID: 25559196.
      View in: PubMed
    39. Nickles D, Madireddy L, Patel N, Isobe N, Miller BL, Baranzini SE, Kramer JH, Oksenberg JR. Whole genome sequences of 2 octogenarians with sustained cognitive abilities. Neurobiol Aging. 2015 Mar; 36(3):1435-8. PMID: 25618617; PMCID: PMC4346472.
    40. Gourraud PA, Khankhanian P, Cereb N, Yang SY, Feolo M, Maiers M, Rioux JD, Hauser S, Oksenberg J. HLA diversity in the 1000 genomes dataset. PLoS One. 2014; 9(7):e97282. PMID: 24988075; PMCID: PMC4079705.
    41. Oksenberg JR. Decoding multiple sclerosis: an update on genomics and future directions. Expert Rev Neurother. 2013 Dec; 13(12 Suppl):11-9. PMID: 24289837.
      View in: PubMed
    42. Hauser SL, Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg JR. Quo vadis? Peering into the future. Ann Neurol. 2013 Dec; 74(6):A5-7. PMID: 24448838.
      View in: PubMed
    43. Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T, Gourraud PA, Stranger BE, Oksenberg J, Olsson T, Taylor BV, Sawcer S, Hafler DA, Carrington M, De Jager PL, de Bakker PI. Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet. 2013 Nov; 9(11):e1003926. PMID: 24278027; PMCID: PMC3836799.
    44. Goris A, van Setten J, Diekstra F, Ripke S, Patsopoulos NA, Sawcer SJ, van Es M, Andersen PM, Melki J, Meininger V, Hardiman O, Landers JE, Brown RH, Shatunov A, Leigh N, Al-Chalabi A, Shaw CE, Traynor BJ, Chiò A, Restagno G, Mora G, Ophoff RA, Oksenberg JR, Van Damme P, Compston A, Robberecht W, Dubois B, van den Berg LH, De Jager PL, Veldink JH, de Bakker PI. No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. Hum Mol Genet. 2014 Apr 01; 23(7):1916-22. PMID: 24234648.
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    45. Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg J, Stewart A, Hauser SL. Have the Annals editors added value? Ann Neurol. 2013 Nov; 74(5):A7-9. PMID: 24353220.
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    46. Harbo HF, Isobe N, Berg-Hansen P, Bos SD, Caillier SJ, Gustavsen MW, Mero IL, Celius EG, Hauser SL, Oksenberg JR, Gourraud PA. Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis. Mult Scler. 2014 May; 20(6):660-8. PMID: 24099750; PMCID: PMC4066985.
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    102. Rioux JD, Goyette P, Vyse TJ, Hammarström L, Fernando MM, Green T, De Jager PL, Foisy S, Wang J, de Bakker PI, Leslie S, McVean G, Padyukov L, Alfredsson L, Annese V, Hafler DA, Pan-Hammarström Q, Matell R, Sawcer SJ, Compston AD, Cree BA, Mirel DB, Daly MJ, Behrens TW, Klareskog L, Gregersen PK, Oksenberg JR, Hauser SL. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18680-5. PMID: 19846760; PMCID: PMC2773992.
    103. McCauley JL, Zuvich RL, Bradford Y, Kenealy SJ, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Mortlock DP, Pericak-Vance MA, Haines JL. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. Genes Immun. 2009 Oct; 10(7):624-30. PMID: 19626040; PMCID: PMC2765552.
    104. Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe'er I, Dudbridge F, Holmans PA, Whittemore AS, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Crowe RR, Oksenberg JR, Mirel DB, Kendler KS, Freedman R, Gejman PV. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature. 2009 Aug 06; 460(7256):753-7. PMID: 19571809.
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    105. Pappas DJ, Coppola G, Gabatto PA, Gao F, Geschwind DH, Oksenberg JR, Baranzini SE. Longitudinal system-based analysis of transcriptional responses to type I interferons. Physiol Genomics. 2009 Aug 07; 38(3):362-71. PMID: 19531577.
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    106. De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet. 2009 Jul; 41(7):776-82. PMID: 19525953; PMCID: PMC2757648.
    107. Vandenbroeck K, Comabella M, Tolosa E, Goertsches R, Brassat D, Hintzen R, Infante-Duarte C, Favorov A, Escorza S, Palacios R, Oksenberg JR, Villoslada P. United Europeans for development of pharmacogenomics in multiple sclerosis network. Pharmacogenomics. 2009 May; 10(5):885-94. PMID: 19450134.
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    109. Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, Ingram G, Booth DR, Heard RN, Stewart GJ, Bogaert E, Dubois B, Harbo HF, Celius EG, Spurkland A, Strange R, Hawkins C, Robertson NP, Dudbridge F, Wason J, De Jager PL, Hafler D, Rioux JD, Ivinson AJ, McCauley JL, Pericak-Vance M, Oksenberg JR, Hauser SL, Sexton D, Haines J, Sawcer S, Compston A. Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. Eur J Hum Genet. 2009 Oct; 17(10):1309-13. PMID: 19293837.
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    110. Baranzini SE, Galwey NW, Wang J, Khankhanian P, Lindberg R, Pelletier D, Wu W, Uitdehaag BM, Kappos L, Polman CH, Matthews PM, Hauser SL, Gibson RA, Oksenberg JR, Barnes MR. Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet. 2009 Jun 01; 18(11):2078-90. PMID: 19286671; PMCID: PMC2678928.
    111. Julian LJ, Vella L, Frankel D, Minden SL, Oksenberg JR, Mohr DC. ApoE alleles, depression and positive affect in multiple sclerosis. Mult Scler. 2009 Mar; 15(3):311-5. PMID: 19244396; PMCID: PMC3045528.
    112. De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA. The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5264-9. PMID: 19237575; PMCID: PMC2664005.
    113. Stüve O, Korth C, Gabatto P, Cameron EM, Hu W, Eagar TN, Monson NL, Frohman EM, Racke MK, Zabetian CP, Oksenberg JR. Genetic polymorphism at codon 129 of the prion protein gene is not associated with multiple sclerosis. Arch Neurol. 2009 Feb; 66(2):280-1. PMID: 19204171.
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    114. Cree BA, Reich DE, Khan O, De Jager PL, Nakashima I, Takahashi T, Bar-Or A, Tong C, Hauser SL, Oksenberg JR. Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA. Arch Neurol. 2009 Feb; 66(2):226-33. PMID: 19204159; PMCID: PMC4334456.
    115. Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg JR, Weiss A. Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):546-51. PMID: 19129486; PMCID: PMC2626740.
    116. Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, De Jager PL, Wicker LS, Todd JA, Hafler DA. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet. 2009 Jan; 5(1):e1000322. PMID: 19119414.
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    117. Ding B, Padyukov L, Lundström E, Seielstad M, Plenge RM, Oksenberg JR, Gregersen PK, Alfredsson L, Klareskog L. Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region. Arthritis Rheum. 2009 Jan; 60(1):30-8. PMID: 19116921; PMCID: PMC2874319.
    118. Okuda DT, Srinivasan R, Oksenberg JR, Goodin DS, Baranzini SE, Beheshtian A, Waubant E, Zamvil SS, Leppert D, Qualley P, Lincoln R, Gomez R, Caillier S, George M, Wang J, Nelson SJ, Cree BA, Hauser SL, Pelletier D. Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures. Brain. 2009 Jan; 132(Pt 1):250-9. PMID: 19022862; PMCID: PMC2638695.
    119. Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, Barkhof F, Radue EW, Lindberg RL, Uitdehaag BM, Johnson MR, Angelakopoulou A, Hall L, Richardson JC, Prinjha RK, Gass A, Geurts JJ, Kragt J, Sombekke M, Vrenken H, Qualley P, Lincoln RR, Gomez R, Caillier SJ, George MF, Mousavi H, Guerrero R, Okuda DT, Cree BA, Green AJ, Waubant E, Goodin DS, Pelletier D, Matthews PM, Hauser SL, Kappos L, Polman CH, Oksenberg JR. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet. 2009 Feb 15; 18(4):767-78. PMID: 19010793; PMCID: PMC4334814.
    120. Comabella M, Río J, Espejo C, Ruiz de Villa M, Al-Zayat H, Nos C, Deisenhammer F, Baranzini SE, Nonell L, López C, Julià E, Oksenberg JR, Montalban X. Changes in matrix metalloproteinases and their inhibitors during interferon-beta treatment in multiple sclerosis. Clin Immunol. 2009 Feb; 130(2):145-50. PMID: 18945642.
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    121. Caillier SJ, Briggs F, Cree BA, Baranzini SE, Fernandez-Viña M, Ramsay PP, Khan O, Royal W, Hauser SL, Barcellos LF, Oksenberg JR. Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis. J Immunol. 2008 Oct 15; 181(8):5473-80. PMID: 18832704; PMCID: PMC4346327.
    122. Nelson MR, Bryc K, King KS, Indap A, Boyko AR, Novembre J, Briley LP, Maruyama Y, Waterworth DM, Waeber G, Vollenweider P, Oksenberg JR, Hauser SL, Stirnadel HA, Kooner JS, Chambers JC, Jones B, Mooser V, Bustamante CD, Roses AD, Burns DK, Ehm MG, Lai EH. The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research. Am J Hum Genet. 2008 Sep; 83(3):347-58. PMID: 18760391; PMCID: PMC2556436.
    123. Corvol JC, Pelletier D, Henry RG, Caillier SJ, Wang J, Pappas D, Casazza S, Okuda DT, Hauser SL, Oksenberg JR, Baranzini SE. Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11839-44. PMID: 18689680; PMCID: PMC2504481.
    124. Barcellos LF, Ramsay PP, Caillier SJ, Sawcer S, Haines J, Schmidt S, Pericak-Vance M, Compston DA, Gabatto P, Hauser SL, Oksenberg JR. Genetic variation in nitric oxide synthase 2A (NOS2A) and risk for multiple sclerosis. Genes Immun. 2008 Sep; 9(6):493-500. PMID: 18580885; PMCID: PMC4020442.
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    126. Rhodes B, Morris DL, Subrahmanyan L, Aubin C, de Leon CF, Kelly JF, Evans DA, Whittaker JC, Oksenberg JR, De Jager PL, Vyse TJ. Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach. Hum Genet. 2008 Jul; 123(6):633-42. PMID: 18500540; PMCID: PMC2630773.
    127. Long BR, Ndhlovu LC, Oksenberg JR, Lanier LL, Hecht FM, Nixon DF, Barbour JD. Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection. J Virol. 2008 May; 82(10):4785-92. PMID: 18305035; PMCID: PMC2346752.
    128. Oksenberg JR, Hauser SL. Neurogenetics in the Annals: dealing with complexity. Ann Neurol. 2008 Feb; 63(2):A11-4. PMID: 18306395.
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    129. Goertsches R, Baranzini SE, Morcillo C, Nos C, Camiña M, Oksenberg JR, Montalban X, Comabella M. Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis. Mult Scler. 2008 Apr; 14(3):412-4. PMID: 18208870.
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    130. Byun E, Caillier SJ, Montalban X, Villoslada P, Fernández O, Brassat D, Comabella M, Wang J, Barcellos LF, Baranzini SE, Oksenberg JR. Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis. Arch Neurol. 2008 Mar; 65(3):337-44. PMID: 18195134.
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    131. McElroy JP, Oksenberg JR. Multiple sclerosis genetics. Curr Top Microbiol Immunol. 2008; 318:45-72. PMID: 18219814.
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    132. Begovich AB, Chang M, Caillier SJ, Lew D, Catanese JJ, Wang J, Hauser SL, Oksenberg JR. The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis. Hum Immunol. 2007 Nov; 68(11):934-7. PMID: 18082575.
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    133. Otaegui D, Mostafavi S, Bernard CC, Lopez de Munain A, Mousavi P, Oksenberg JR, Baranzini SE. Increased transcriptional activity of milk-related genes following the active phase of experimental autoimmune encephalomyelitis and multiple sclerosis. J Immunol. 2007 Sep 15; 179(6):4074-82. PMID: 17785846.
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    134. McCauley JL, Kenealy SJ, Margulies EH, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg JR, Pericak-Vance MA, Haines JL, Mortlock DP. SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach. BMC Genomics. 2007 Aug 06; 8:266. PMID: 17683615; PMCID: PMC1959193.
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    136. Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B, Oksenberg JR, Hauser SL. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med. 2007 Aug 30; 357(9):851-62. PMID: 17660530.
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    137. Sriram U, Wong M, Caillier SJ, Hecht FM, Elkins MK, Levy JA, Oksenberg JR, Baranzini SE. Quantitative longitudinal analysis of T cell receptor repertoire expression in HIV-infected patients on antiretroviral and interleukin-2 therapy. AIDS Res Hum Retroviruses. 2007 May; 23(5):741-7. PMID: 17531001.
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    138. Fernald GH, Knott S, Pachner A, Caillier SJ, Narayan K, Oksenberg JR, Mousavi P, Baranzini SE. Genome-wide network analysis reveals the global properties of IFN-beta immediate transcriptional effects in humans. J Immunol. 2007 Apr 15; 178(8):5076-85. PMID: 17404290.
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    139. Johnston SC, Lowenstein DH, Ferriero DM, Messing RO, Oksenberg JR, Hauser SL. Early editorial manuscript screening versus obligate peer review: a randomized trial. Ann Neurol. 2007 Apr; 61(4):A10-2. PMID: 17444512.
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    140. Barbour JD, Sriram U, Caillier SJ, Levy JA, Hecht FM, Oksenberg JR. Synergy or independence? Deciphering the interaction of HLA Class I and NK cell KIR alleles in early HIV-1 disease progression. PLoS Pathog. 2007 Apr; 3(4):e43. PMID: 17447840; PMCID: PMC1853116.
    141. Pedemonte E, Benvenuto F, Casazza S, Mancardi G, Oksenberg JR, Uccelli A, Baranzini SE. The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse. BMC Genomics. 2007 Mar 06; 8:65. PMID: 17341312; PMCID: PMC1821333.
    142. Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne J, Beck S, Trowsdale J, Caillier SJ, Ivinson AJ, Green T, Pobywajlo S, Lander ES, Pericak-Vance MA, Haines JL, Daly MJ, Oksenberg JR, Hauser SL, Compston A, Hafler DA, Rioux JD, Sawcer S. A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol. 2007 Mar; 61(3):228-36. PMID: 17252545; PMCID: PMC2737610.
    143. Hensiek AE, Seaman SR, Barcellos LF, Oturai A, Eraksoi M, Cocco E, Vecsei L, Stewart G, Dubois B, Bellman-Strobl J, Leone M, Andersen O, Bencsik K, Booth D, Celius EG, Harbo HF, Hauser SL, Heard R, Hillert J, Myhr KM, Marrosu MG, Oksenberg JR, Rajda C, Sawcer SJ, Sørensen PS, Zipp F, Compston DA. Familial effects on the clinical course of multiple sclerosis. Neurology. 2007 Jan 30; 68(5):376-83. PMID: 17261686.
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    144. Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L. Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. J Exp Med. 2007 Feb 19; 204(2):321-30. PMID: 17261635.
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    145. Barcellos LF, Kamdar BB, Ramsay PP, DeLoa C, Lincoln RR, Caillier S, Schmidt S, Haines JL, Pericak-Vance MA, Oksenberg JR, Hauser SL. Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. Lancet Neurol. 2006 Nov; 5(11):924-31. PMID: 17052659.
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    146. Hauser SL, Oksenberg JR. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron. 2006 Oct 05; 52(1):61-76. PMID: 17015227.
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    147. Motsinger AA, Brassat D, Caillier SJ, Erlich HA, Walker K, Steiner LL, Barcellos LF, Pericak-Vance MA, Schmidt S, Gregory S, Hauser SL, Haines JL, Oksenberg JR, Ritchie MD. Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes. Neurogenetics. 2007 Jan; 8(1):11-20. PMID: 17024427.
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    149. Schmidt S, Pericak-Vance MA, Sawcer S, Barcellos LF, Hart J, Sims J, Prokop AM, van der Walt J, DeLoa C, Lincoln RR, Oksenberg JR, Compston A, Hauser SL, Haines JL, Gregory SG. Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis. Genes Immun. 2006 Jul; 7(5):384-92. PMID: 16738668.
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    150. Burwick RM, Ramsay PP, Haines JL, Hauser SL, Oksenberg JR, Pericak-Vance MA, Schmidt S, Compston A, Sawcer S, Cittadella R, Savettieri G, Quattrone A, Polman CH, Uitdehaag BM, Zwemmer JN, Hawkins CP, Ollier WE, Weatherby S, Enzinger C, Fazekas F, Schmidt H, Schmidt R, Hillert J, Masterman T, Hogh P, Niino M, Kikuchi S, Maciel P, Santos M, Rio ME, Kwiecinski H, Zakrzewska-Pniewska B, Evangelou N, Palace J, Barcellos LF. APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers. Neurology. 2006 May 09; 66(9):1373-83. PMID: 16682670.
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    152. Kenealy SJ, Herrel LA, Bradford Y, Schnetz-Boutaud N, Oksenberg JR, Hauser SL, Barcellos LF, Schmidt S, Gregory SG, Pericak-Vance MA, Haines JL. Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44. Genes Immun. 2006 Jan; 7(1):73-6. PMID: 16341055.
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    153. Traherne JA, Barcellos LF, Sawcer SJ, Compston A, Ramsay PP, Hauser SL, Oksenberg JR, Trowsdale J. Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15. Hum Mol Genet. 2006 Jan 01; 15(1):155-61. PMID: 16321988.
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    154. Fernald GH, Yeh RF, Hauser SL, Oksenberg JR, Baranzini SE. Mapping gene activity in complex disorders: Integration of expression and genomic scans for multiple sclerosis. J Neuroimmunol. 2005 Oct; 167(1-2):157-69. PMID: 16129498.
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    155. Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg JR, Hafler DA. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet. 2005 Oct; 37(10):1113-8. PMID: 16186815.
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    156. Frohman EM, Filippi M, Stuve O, Waxman SG, Corboy J, Phillips JT, Lucchinetti C, Wilken J, Karandikar N, Hemmer B, Monson N, De Keyser J, Hartung H, Steinman L, Oksenberg JR, Cree BA, Hauser S, Racke MK. Characterizing the mechanisms of progression in multiple sclerosis: evidence and new hypotheses for future directions. Arch Neurol. 2005 Sep; 62(9):1345-56. PMID: 16157741.
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    158. Sawcer S, Ban M, Maranian M, Yeo TW, Compston A, Kirby A, Daly MJ, De Jager PL, Walsh E, Lander ES, Rioux JD, Hafler DA, Ivinson A, Rimmler J, Gregory SG, Schmidt S, Pericak-Vance MA, Akesson E, Hillert J, Datta P, Oturai A, Ryder LP, Harbo HF, Spurkland A, Myhr KM, Laaksonen M, Booth D, Heard R, Stewart G, Lincoln R, Barcellos LF, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL. A high-density screen for linkage in multiple sclerosis. Am J Hum Genet. 2005 Sep; 77(3):454-67. PMID: 16080120; PMCID: PMC1226210.
    159. Baranzini SE, Bernard CC, Oksenberg JR. Modular transcriptional activity characterizes the initiation and progression of autoimmune encephalomyelitis. J Immunol. 2005 Jun 01; 174(11):7412-22. PMID: 15905590.
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    160. Baranzini SE, Oksenberg JR. Genomics and new targets for multiple sclerosis. Pharmacogenomics. 2005 Mar; 6(2):151-61. PMID: 15882133.
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    161. Elkins MK, Vittinghoff E, Baranzini SE, Hecht FM, Sriram U, Busch MP, Levy JA, Oksenberg JR. Longitudinal analysis of B cell repertoire and antibody gene rearrangements during early HIV infection. Genes Immun. 2005 Feb; 6(1):66-9. PMID: 15538390.
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    162. Oksenberg JR, Hauser SL. Genetics of multiple sclerosis. Neurol Clin. 2005 Feb; 23(1):61-75, vi. PMID: 15661088.
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    163. Brassat D, Salemi G, Barcellos LF, McNeill G, Proia P, Hauser SL, Oksenberg JR, Savettieri G. The HLA locus and multiple sclerosis in Sicily. Neurology. 2005 Jan 25; 64(2):361-3. PMID: 15668443.
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    164. Begovich AB, Caillier SJ, Alexander HC, Penko JM, Hauser SL, Barcellos LF, Oksenberg JR. The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis. Am J Hum Genet. 2005 Jan; 76(1):184-7. PMID: 15580548; PMCID: PMC1196423.
    165. Baranzini SE, Mousavi P, Rio J, Caillier SJ, Stillman A, Villoslada P, Wyatt MM, Comabella M, Greller LD, Somogyi R, Montalban X, Oksenberg JR. Transcription-based prediction of response to IFNbeta using supervised computational methods. PLoS Biol. 2005 Jan; 3(1):e2. PMID: 15630474; PMCID: PMC539058.
    166. Cree BA, Khan O, Bourdette D, Goodin DS, Cohen JA, Marrie RA, Glidden D, Weinstock-Guttman B, Reich D, Patterson N, Haines JL, Pericak-Vance M, DeLoa C, Oksenberg JR, Hauser SL. Clinical characteristics of African Americans vs Caucasian Americans with multiple sclerosis. Neurology. 2004 Dec 14; 63(11):2039-45. PMID: 15596747.
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    167. Kenealy SJ, Babron MC, Bradford Y, Schnetz-Boutaud N, Haines JL, Rimmler JB, Schmidt S, Pericak-Vance MA, Barcellos LF, Lincoln RR, Oksenberg JR, Hauser SL, Clanet M, Brassat D, Edan G, Yaouanq J, Semana G, Cournu-Rebeix I, Lyon-Caen O, Fontaine B. A second-generation genomic screen for multiple sclerosis. Am J Hum Genet. 2004 Dec; 75(6):1070-8. PMID: 15494893; PMCID: PMC1182142.
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    171. Villoslada P, Oksenberg JR, Rio J, Montalban X. Clinical characteristics of responders to interferon therapy for relapsing MS. Neurology. 2004 May 11; 62(9):1653; author reply 1653. PMID: 15136712.
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    173. Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg JR, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ, Reich D. Methods for high-density admixture mapping of disease genes. Am J Hum Genet. 2004 May; 74(5):979-1000. PMID: 15088269; PMCID: PMC1181990.
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    175. Oksenberg JR, Barcellos LF, Cree BA, Baranzini SE, Bugawan TL, Khan O, Lincoln RR, Swerdlin A, Mignot E, Lin L, Goodin D, Erlich HA, Schmidt S, Thomson G, Reich DE, Pericak-Vance MA, Haines JL, Hauser SL. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet. 2004 Jan; 74(1):160-7. PMID: 14669136; PMCID: PMC1181903.
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    177. Caillier S, Barcellos LF, Baranzini SE, Swerdlin A, Lincoln RR, Steinman L, Martin E, Haines JL, Pericak-Vance M, Hauser SL, Oksenberg JR. Osteopontin polymorphisms and disease course in multiple sclerosis. Genes Immun. 2003 Jun; 4(4):312-5. PMID: 12761568.
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    178. Sriram U, Barcellos LF, Villoslada P, Rio J, Baranzini SE, Caillier S, Stillman A, Hauser SL, Montalban X, Oksenberg JR. Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis. Genes Immun. 2003 Mar; 4(2):147-52. PMID: 12618863.
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    179. Barcellos LF, Oksenberg JR, Begovich AB, Martin ER, Schmidt S, Vittinghoff E, Goodin DS, Pelletier D, Lincoln RR, Bucher P, Swerdlin A, Pericak-Vance MA, Haines JL, Hauser SL. HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course. Am J Hum Genet. 2003 Mar; 72(3):710-6. PMID: 12557126; PMCID: PMC1180245.
    180. Haines JL, Bradford Y, Garcia ME, Reed AD, Neumeister E, Pericak-Vance MA, Rimmler JB, Menold MM, Martin ER, Oksenberg JR, Barcellos LF, Lincoln R, Hauser SL. Multiple susceptibility loci for multiple sclerosis. Hum Mol Genet. 2002 Sep 15; 11(19):2251-6. PMID: 12217953.
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    181. Haukim N, Bidwell JL, Smith AJ, Keen LJ, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases, supplement 2. Genes Immun. 2002 Sep; 3(6):313-30. PMID: 12209358.
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    182. Villoslada P, Barcellos LF, Rio J, Begovich AB, Tintore M, Sastre-Garriga J, Baranzini SE, Casquero P, Hauser SL, Montalban X, Oksenberg JR. The HLA locus and multiple sclerosis in Spain. Role in disease susceptibility, clinical course and response to interferon-beta. J Neuroimmunol. 2002 Sep; 130(1-2):194-201. PMID: 12225902.
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    183. Baranzini SE, Laxer K, Bollen A, Oksenberg JR. Gene expression analysis reveals altered brain transcription of glutamate receptors and inflammatory genes in a patient with chronic focal (Rasmussen's) encephalitis. J Neuroimmunol. 2002 Jul; 128(1-2):9-15. PMID: 12098505.
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    184. Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, Langer-Gould A, Strober S, Cannella B, Allard J, Klonowski P, Austin A, Lad N, Kaminski N, Galli SJ, Oksenberg JR, Raine CS, Heller R, Steinman L. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med. 2002 May; 8(5):500-8. PMID: 11984595.
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    185. Grams SE, Moonsamy PV, Mano C, Oksenberg JR, Begovich AB. Two new HLA-B alleles, B*4422 and B*4704, identified in a study of families with autoimmunity. Tissue Antigens. 2002 Apr; 59(4):338-40. PMID: 12135438.
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    186. Steinman L, Martin R, Bernard C, Conlon P, Oksenberg JR. Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy. Annu Rev Neurosci. 2002; 25:491-505. PMID: 12052918.
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    187. Baranzini SE, Laxer K, Saketkhoo R, Elkins MK, Parent JM, Mantegazza R, Oksenberg JR. Analysis of antibody gene rearrangement, usage, and specificity in chronic focal encephalitis. Neurology. 2002 Mar 12; 58(5):709-16. PMID: 11889232.
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    188. Baranzini SE, Oksenberg JR, Hauser SL. New insights into the genetics of multiple sclerosis. J Rehabil Res Dev. 2002 Mar-Apr; 39(2):201-9. PMID: 12051464.
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    189. Schmidt S, Barcellos LF, DeSombre K, Rimmler JB, Lincoln RR, Bucher P, Saunders AM, Lai E, Martin ER, Vance JM, Oksenberg JR, Hauser SL, Pericak-Vance MA, Haines JL. Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis. Am J Hum Genet. 2002 Mar; 70(3):708-17. PMID: 11836653; PMCID: PMC384947.
    190. Patarroyo JC, Stuve O, Piskurich JF, Hauser SL, Oksenberg JR, Zamvil SS. Single nucleotide polymorphisms in MHC2TA, the gene encoding the MHC class II transactivator (CIITA). Genes Immun. 2002 Feb; 3(1):34-7. PMID: 11857059.
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    191. Barcellos LF, Oksenberg JR, Green AJ, Bucher P, Rimmler JB, Schmidt S, Garcia ME, Lincoln RR, Pericak-Vance MA, Haines JL, Hauser SL. Genetic basis for clinical expression in multiple sclerosis. Brain. 2002 Jan; 125(Pt 1):150-8. PMID: 11834600.
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    192. Chabas D, Baranzini SE, Mitchell D, Bernard CC, Rittling SR, Denhardt DT, Sobel RA, Lock C, Karpuj M, Pedotti R, Heller R, Oksenberg JR, Steinman L. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science. 2001 Nov 23; 294(5547):1731-5. PMID: 11721059.
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    193. Pericak-Vance MA, Rimmler JB, Martin ER, Haines JL, Garcia ME, Oksenberg JR, Barcellos LF, Lincoln R, Goodkin DE, Hauser SL. Linkage and association analysis of chromosome 19q13 in multiple sclerosis. Neurogenetics. 2001 Oct; 3(4):195-201. PMID: 11714099.
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    194. Barcellos LF, Caillier S, Dragone L, Elder M, Vittinghoff E, Bucher P, Lincoln RR, Pericak-Vance M, Haines JL, Weiss A, Hauser SL, Oksenberg JR. PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients. Nat Genet. 2001 Sep; 29(1):23-4. PMID: 11528386.
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    195. Green AJ, Bollen AW, Berger MS, Oksenberg JR, Hauser SL. Multiple sclerosis and oligodendroglioma. Mult Scler. 2001 Aug; 7(4):269-73. PMID: 11548988.
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    196. Green AJ, Barcellos LF, Rimmler JB, Garcia ME, Caillier S, Lincoln RR, Bucher P, Pericak-Vance MA, Haines JL, Hauser SL, Oksenberg JR. Sequence variation in the transforming growth factor-beta1 (TGFB1) gene and multiple sclerosis susceptibility. J Neuroimmunol. 2001 May 01; 116(1):116-24. PMID: 11311337.
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    197. Klitz W, Brautbar C, Schito AM, Barcellos LF, Oksenberg JR. Evolution of the CCR5 Delta32 mutation based on haplotype variation in Jewish and Northern European population samples. Hum Immunol. 2001 May; 62(5):530-8. PMID: 11334678.
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    198. Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases, supplement 1. Genes Immun. 2001 Apr; 2(2):61-70. PMID: 11393658.
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    199. Oksenberg JR, Baranzini SE, Barcellos LF, Hauser SL. Multiple sclerosis: genomic rewards. J Neuroimmunol. 2001 Feb 15; 113(2):171-84. PMID: 11164900.
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    200. Schito AM, Vittinghoff E, Hecht FM, Elkins MK, Kahn JO, Levy JA, Oksenberg JR. Longitudinal analysis of T-cell receptor gene use by CD8(+) T cells in early human immunodeficiency virus infection in patients receiving highly active antiretroviral therapy. Blood. 2001 Jan 01; 97(1):214-20. PMID: 11133763.
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    201. Baranzini SE, Elfstrom C, Chang SY, Butunoi C, Murray R, Higuchi R, Oksenberg JR. Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression. J Immunol. 2000 Dec 01; 165(11):6576-82. PMID: 11086101.
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    202. Hauser SL, Oksenberg JR, Lincoln R, Garovoy J, Beck RW, Cole SR, Moke PS, Kip KE, Gal RL, Long DT. Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS. Optic Neuritis Study Group. Neurology. 2000 May 09; 54(9):1859-61. PMID: 10802800.
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    203. Oksenberg JR, Barcellos LF. The complex genetic aetiology of multiple sclerosis. J Neurovirol. 2000 May; 6 Suppl 2:S10-4. PMID: 10871777.
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    204. Barcellos LF, Schito AM, Rimmler JB, Vittinghoff E, Shih A, Lincoln R, Callier S, Elkins MK, Goodkin DE, Haines JL, Pericak-Vance MA, Hauser SL, Oksenberg JR. CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group. Immunogenetics. 2000 Apr; 51(4-5):281-8. PMID: 10803840.
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    205. Karni A, Kohn Y, Safirman C, Abramsky O, Barcellos L, Oksenberg JR, Kahana E, Karussis D, Chapman J, Brautbar C. Evidence for the genetic role of human leukocyte antigens in low frequency DRB1*1501 multiple sclerosis patients in Israel. Mult Scler. 1999 Dec; 5(6):410-5. PMID: 10618697.
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    206. Baranzini SE, Jeong MC, Butunoi C, Murray RS, Bernard CC, Oksenberg JR. B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J Immunol. 1999 Nov 01; 163(9):5133-44. PMID: 10528220.
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    207. Fontaine B, Cournu I, Arnaud I, Babron MC, Eichenbaum-Voline S, Oksenberg JR, Pericak-Vance MA, Haines JL, Semama G, Liblau R, Lyon-Caen O, Clerget-Darpoux F, Clanet M, Hauser SL. Chromosome 17q22-q24 and multiple sclerosis genetic susceptibility. American-French Multiple Sclerosis Genetic Group. Genes Immun. 1999 Nov; 1(2):149-50. PMID: 11196661.
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    208. Lock C, Oksenberg J, Steinman L. The role of TNFalpha and lymphotoxin in demyelinating disease. Ann Rheum Dis. 1999 Nov; 58 Suppl 1:I121-8. PMID: 10577988; PMCID: PMC1766588.
    209. Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases. Genes Immun. 1999 Sep; 1(1):3-19. PMID: 11197303.
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    210. Seboun E, Oksenberg JR, Rombos A, Usuku K, Goodkin DE, Lincoln RR, Wong M, Pham-Dinh D, Boesplug-Tanguy O, Carsique R, Fitoussi R, Gartioux C, Reyes C, Ribierre F, Faure S, Fizames C, Gyapay G, Weissenbach J, Dautigny A, Rimmler JB, Garcia ME, Pericak-Vance MA, Haines JL, Hauser SL. Linkage analysis of candidate myelin genes in familial multiple sclerosis. Neurogenetics. 1999 Sep; 2(3):155-62. PMID: 10541588.
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    211. Conlon P, Oksenberg JR, Zhang J, Steinman L. The immunobiology of multiple sclerosis: an autoimmune disease of the central nervous system. Neurobiol Dis. 1999 Jun; 6(3):149-66. PMID: 10408805.
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    212. Oksenberg JR, Barcellos LF, Hauser SL. Genetic aspects of multiple sclerosis. Semin Neurol. 1999; 19(3):281-8. PMID: 12194384.
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    213. Jeong MC, Izikson L, Uccelli A, Brocke S, Oksenberg JR. Differential display analysis of murine encephalitogenic mRNA. Int Immunol. 1998 Dec; 10(12):1819-23. PMID: 9885902.
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    214. Haines JL, Terwedow HA, Burgess K, Pericak-Vance MA, Rimmler JB, Martin ER, Oksenberg JR, Lincoln R, Zhang DY, Banatao DR, Gatto N, Goodkin DE, Hauser SL. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group. Hum Mol Genet. 1998 Aug; 7(8):1229-34. PMID: 9668163.
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    215. Diaz-Villoslada P, Oksenberg JR. Chronic inflammatory diseases of the nervous system. Curr Opin Neurol. 1998 Jun; 11(3):235-40. PMID: 9642542.
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    216. Jeong MC, Navani A, Oksenberg JR. Limited allelic polymorphism in the human interleukin-3 gene. Mol Cell Probes. 1998 Feb; 12(1):49-53. PMID: 9584078.
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    217. Oksenberg JR, Stavri GT, Jeong MC, Garovoy N, Salisbury JR, Erusalimsky JD. Analysis of the T-cell receptor repertoire in human atherosclerosis. Cardiovasc Res. 1997 Nov; 36(2):256-67. PMID: 9463637.
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    218. Hvas J, McLean C, Justesen J, Kannourakis G, Steinman L, Oksenberg JR, Bernard CC. Perivascular T cells express the pro-inflammatory chemokine RANTES mRNA in multiple sclerosis lesions. Scand J Immunol. 1997 Aug; 46(2):195-203. PMID: 9584001.
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    219. Oksenberg JR, Hauser SL. New insights into the immunogenetics of multiple sclerosis. Curr Opin Neurol. 1997 Jun; 10(3):181-5. PMID: 9229123.
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    220. Karpuj MV, Steinman L, Oksenberg JR. Multiple sclerosis: a polygenic disease involving epistatic interactions, germline rearrangements and environmental effects. Neurogenetics. 1997 May; 1(1):21-8. PMID: 10735270.
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    221. Li Y, Uccelli A, Laxer KD, Jeong MC, Vinters HV, Tourtellotte WW, Hauser SL, Oksenberg JR. Local-clonal expansion of infiltrating T lymphocytes in chronic encephalitis of Rasmussen. J Immunol. 1997 Feb 01; 158(3):1428-37. PMID: 9013988.
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    222. Uccelli A, Oksenberg JR, Jeong MC, Genain CP, Rombos T, Jaeger EE, Giunti D, Lanchbury JS, Hauser SL. Characterization of the TCRB chain repertoire in the New World monkey Callithrix jacchus. J Immunol. 1997 Feb 01; 158(3):1201-7. PMID: 9013960.
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    223. Leppert D, Waubant E, Bürk MR, Oksenberg JR, Hauser SL. Interferon beta-1b inhibits gelatinase secretion and in vitro migration of human T cells: a possible mechanism for treatment efficacy in multiple sclerosis. Ann Neurol. 1996 Dec; 40(6):846-52. PMID: 9007089.
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    224. Oksenberg JR. Immunogenetics and heterogeneity in multiple sclerosis. Ann Neurol. 1996 Oct; 40(4):557-8. PMID: 8871572.
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    225. Haines JL, Ter-Minassian M, Bazyk A, Gusella JF, Kim DJ, Terwedow H, Pericak-Vance MA, Rimmler JB, Haynes CS, Roses AD, Lee A, Shaner B, Menold M, Seboun E, Fitoussi RP, Gartioux C, Reyes C, Ribierre F, Gyapay G, Weissenbach J, Hauser SL, Goodkin DE, Lincoln R, Usuku K, Oksenberg JR. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group. Nat Genet. 1996 Aug; 13(4):469-71. PMID: 8696344.
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    226. Waisman A, Ruiz PJ, Hirschberg DL, Gelman A, Oksenberg JR, Brocke S, Mor F, Cohen IR, Steinman L. Suppressive vaccination with DNA encoding a variable region gene of the T-cell receptor prevents autoimmune encephalomyelitis and activates Th2 immunity. Nat Med. 1996 Aug; 2(8):899-905. PMID: 8705860.
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    227. Oksenberg JR, Seboun E, Hauser SL. Genetics of demyelinating diseases. Brain Pathol. 1996 Jul; 6(3):289-302. PMID: 8864285.
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    228. Szafer F, Price VH, Oksenberg JR, Steinman L. T-cell receptor repertoire V beta in alopecia areata. J Invest Dermatol. 1995 May; 104(5 Suppl):22S-24S. PMID: 7738379.
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    229. Steinman L, Miller A, Bernard CC, Oksenberg JR. The epigenetics of multiple sclerosis: clues to etiology and a rationale for immune therapy. Annu Rev Neurosci. 1994; 17:247-65. PMID: 8210175.
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    230. Szafer F, Oksenberg JR, Steinman L. New allelic polymorphisms in TAP genes. Immunogenetics. 1994; 39(5):374. PMID: 8168860.
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    231. Oksenberg JR, Begovich AB, Erlich HA, Steinman L. Genetic factors in multiple sclerosis. JAMA. 1993 Nov 17; 270(19):2362-9. PMID: 8230601.
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    232. Struyk L, Kurnick JT, Hawes GE, van Laar JM, Schipper R, Oksenberg JR, Steinman L, de Vries RR, Breedveld FC, van den Elsen P. T-cell receptor V-gene usage in synovial fluid lymphocytes of patients with chronic arthritis. Hum Immunol. 1993 Aug; 37(4):237-51. PMID: 8300409.
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    233. Kan-Mitchell J, Huang XQ, Steinman L, Oksenberg JR, Harel W, Parker JW, Goedegebuure PS, Darrow TL, Mitchell MS. Clonal analysis of in vivo activated CD8+ cytotoxic T lymphocytes from a melanoma patient responsive to active specific immunotherapy. Cancer Immunol Immunother. 1993 Jul; 37(1):15-25. PMID: 8513449.
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    234. Hvas J, Oksenberg JR, Fernando R, Steinman L, Bernard CC. Gamma delta T cell receptor repertoire in brain lesions of patients with multiple sclerosis. J Neuroimmunol. 1993 Jul; 46(1-2):225-34. PMID: 8395544.
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    235. Melms A, Oksenberg JR, Malcherek G, Schoepfer R, Müller CA, Lindstrom J, Steinman L. T-cell receptor gene usage of acetylcholine receptor-specific T-helper cells. Ann N Y Acad Sci. 1993 Jun 21; 681:313-4. PMID: 8357179.
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    236. Mantegazza R, Andreetta F, Bernasconi P, Baggi F, Oksenberg JR, Simoncini O, Mora M, Cornelio F, Steinman L. Analysis of T cell receptor repertoire of muscle-infiltrating T lymphocytes in polymyositis. Restricted V alpha/beta rearrangements may indicate antigen-driven selection. J Clin Invest. 1993 Jun; 91(6):2880-6. PMID: 8514895; PMCID: PMC443358.
    237. Oksenberg JR, Panzara MA, Steinman L. Multiple sclerosis: from immunogenetics to immunotherapy. J Neurol Sci. 1993 Apr; 115 Suppl:S29-37. PMID: 8340790.
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    238. Oksenberg JR, Panzara MA, Begovich AB, Mitchell D, Erlich HA, Murray RS, Shimonkevitz R, Sherritt M, Rothbard J, Bernard CC. Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature. 1993 Mar 04; 362(6415):68-70. PMID: 7680433.
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    239. Panzara MA, Gussoni E, Steinman L, Oksenberg JR. Analysis of the T cell repertoire using the PCR and specific oligonucleotide primers. Biotechniques. 1992 May; 12(5):728-35. PMID: 1515141.
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    240. Panzara MA, Oksenberg JR, Steinman L. The polymerase chain reaction for detection of T-cell antigen receptor expression. Curr Opin Immunol. 1992 Apr; 4(2):205-10. PMID: 1605910.
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    241. De Magistris MT, Di Tommaso A, Domenighini M, Censini S, Tagliabue A, Oksenberg JR, Steinman L, Judd AK, O'Sullivan D, Rappuoli R. Interaction of the pertussis toxin peptide containing residues 30-42 with DR1 and the T-cell receptors of 12 human T-cell clones. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2990-4. PMID: 1313575; PMCID: PMC48789.
    242. Bucht A, Oksenberg JR, Lindblad S, Grönberg A, Steinman L, Klareskog L. Characterization of T-cell receptor alpha beta repertoire in synovial tissue from different temporal phases of rheumatoid arthritis. Scand J Immunol. 1992 Feb; 35(2):159-65. PMID: 1531390.
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    243. Steinman L, Oksenberg JR, Bernard CA. Polymorphism in MS. Neurology. 1992 Feb; 42(2):466-7. PMID: 1346550.
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    244. Sherritt MA, Oksenberg J, de Rosbo NK, Bernard CC. Influence of HLA-DR2, HLA-DPw4, and T cell receptor alpha chain genes on the susceptibility to multiple sclerosis. Int Immunol. 1992 Feb; 4(2):177-81. PMID: 1352460.
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    245. Steinman L, Oksenberg JR, Bernard CC. Association of susceptibility to multiple sclerosis with TCR genes. Immunol Today. 1992 Feb; 13(2):49-51. PMID: 1533525.
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    246. Oksenberg JR, Steinman L. New approaches to the therapy of demyelinating disease. Curr Opin Neurobiol. 1991 Oct; 1(3):436-40. PMID: 1821688.
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    247. Oksenberg JR, Stuart S, Begovich AB, Bell RB, Erlich HA, Steinman L, Bernard CC. Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature. 1991 Sep 05; 353(6339):94. PMID: 1652695.
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    248. Kan-Mitchell J, Liggett PE, Harel W, Steinman L, Nitta T, Oksenberg JR, Posner MR, Mitchell MS. Lymphocytes cytotoxic to uveal and skin melanoma cells from peripheral blood of ocular melanoma patients. Cancer Immunol Immunother. 1991; 33(5):333-40. PMID: 1831067.
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    249. Oksenberg JR, Mantegazza R, Sakai K, Bernard CC, Steinman L. HTLV-I sequences are not detected in peripheral blood genomic DNA or in brain cDNA of multiple sclerosis patients. Ann Neurol. 1990 Oct; 28(4):574-7. PMID: 2252368.
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    250. Nitta T, Oksenberg JR, Rao NA, Steinman L. Predominant expression of T cell receptor V alpha 7 in tumor-infiltrating lymphocytes of uveal melanoma. Science. 1990 Aug 10; 249(4969):672-4. PMID: 2382141.
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    251. Begovich AB, Helmuth RC, Oksenberg JR, Sakai K, Tabira T, Sasazuki T, Steinman L, Erlich HA. HLA-DP beta and susceptibility to multiple sclerosis: an analysis of caucasoid and Japanese patient populations. Hum Immunol. 1990 Aug; 28(4):365-72. PMID: 2391251.
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    252. Mantegazza R, Oksenberg JR, Baggi F, Antozzi C, Illeni MT, Pellegris G, Cornelio F, Steinman L. Increased incidence of certain TCR and HLA genes associated with myasthenia gravis in Italians. J Autoimmun. 1990 Aug; 3(4):431-40. PMID: 1977403.
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    253. Oksenberg JR, Stuart S, Begovich AB, Bell RB, Erlich HA, Steinman L, Bernard CC. Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature. 1990 May 24; 345(6273):344-6. PMID: 1971424.
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    254. Oksenberg JR, Ko C, Judd AK, Lim M, Kent A, Schoolnik GK, Steinman L. Multiple T and B cell epitopes in the S1 subunit ("A"-monomer) of the pertussis toxin molecule. J Immunol. 1989 Dec 15; 143(12):4227-31. PMID: 2480389.
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    255. Oksenberg D, Oksenberg JR, Sakai K, Peroutka SJ, Steinman L. Cyclic adenosine 3',5'-monophosphate metabolism in activated T-cell clones. Immunology. 1989 Aug; 67(4):484-8. PMID: 2475434; PMCID: PMC1385318.
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    257. Oksenberg JR, Steinman L. The role of the MHC and T-cell receptor in susceptibility to multiple sclerosis. Curr Opin Immunol. 1989-1990 Apr; 2(4):619-21. PMID: 2700905.
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    258. Oksenberg JR, Judd AK, Ko C, Lim M, Fernandez R, Schoolnik GK, Steinman L. MHC-restricted recognition of immunogenic T cell epitopes of pertussis toxin reveals determinants in man distinct from the ADP-ribosylase active site. J Exp Med. 1988 Nov 01; 168(5):1855-64. PMID: 2460578; PMCID: PMC2189123.
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