Loading...

Jorge Oksenberg, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentNeurology
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-476-1335
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    VA Multiple Sclerosis Center of Excellence 2009The John N. Whitaker Memorial Lecture
    UCSF2005G.A. Zimmermann Endowed Chair in Neurology

    Collapse Overview 
    Collapse Overview
    Immune-mediated neurological impairment is the outcome of a rather extensive and coordinated series of events that include peripheral lymphocyte activation, disruption of the blood-brain barrier, cellular infiltration into the brain parenchyma, local inflammation and tissue injury. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules (including free radicals, proteases, vasoactive amines, and excitatory neurotransmitters) induce and regulate numerous critical cell functions that perpetuate inflammation, leading to tissue injury, neuro-degeneration, and neurological deficits. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extend conditioned by the unique amino acid sequences that define allelic variants on each of the participating molecules. Genes, either in their germline configuration and/or as part of complex functional networks, play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy.

    The principal aim of our laboratory (see link below) is to identify the major genetic factors that predispose to autoimmunity in the central nervous system and modulate disease presentation and progression. The availability of highly sensitive and high-capacity methods for analysis of gene variation and expression combined with the implementation of algorithms that predict behaviors in complex biological circuits provides an outstanding opportunity to facilitate progress in the integration of multiple data sources and functional interpretation of physiological and laboratory results. Our goal is to apply novel molecular, informatic, statistical, and epidemiological approaches to illuminate fully the genetics of autoimmune demyelination. Specifically, our research plan includes:
    • Genome wide gene/haplotype mapping for the discovery of MS genes
    • Genotype-phenotype correlations in MS
    • Gene-environment correlations in MS
    • Genomic and clinical study of MS populations at low and intermediate risk
    • MS pharmacogenomics
    • Gene expression networks in human and experimental neuroinflammation


    Collapse Research 
    Collapse Research Activities and Funding
    MHC variation at high resolution in multiple sclerosis
    NIH/NINDS R01NS102153Aug 15, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Immunogenetic Determinants of Disease Risk in Neurological Disease
    NIH/NINDS U19NS095774Jul 1, 2015 - Jul 31, 2020
    Role: Principal Investigator
    The contribution of common and rare variants to autoimmunity in African Americans
    NIH/NINDS R01NS076492Aug 15, 2011 - Apr 30, 2015
    Role: Principal Investigator
    Immunogenetic Studies in Multiple Sclerosis
    NIH/NINDS R01NS046297Jul 16, 2003 - Dec 31, 2014
    Role: Principal Investigator
    Immunomodulation in Multiple Sclerosis by Interferon B
    NIH/NINDS R01NS042911Sep 30, 2002 - Aug 31, 2007
    Role: Principal Investigator
    IMMUNOLOGICAL BASIS OF EPILEPSY
    NIH/NINDS R01NS035761Jun 16, 1997 - May 31, 2001
    Role: Principal Investigator
    Gene linkage study of multiple sclerosis sibling pairs
    NIH/NINDS R01NS026799Dec 1, 1988 - Jul 31, 2019
    Role: Co-Principal Investigator

    Collapse ORNG Applications 
    Collapse Global Health
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Creary LE, Mallempati KC, Gangavarapu S, Caillier SJ, Oksenberg J, Fernández-Vina MA. Deconstruction of HLA-DRB1*04:01:01 and HLA-DRB1*15:01:01 class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosis. Mult Scler. 2018 Apr 01; 1352458518770019. PMID: 29683085.
      View in: PubMed
    2. Canto E, Isobe N, Didonna A. Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. J Neuroinflammation. 2018 Mar 07; 15(1):72. PMID: 29514694.
      View in: PubMed
    3. Mack SJ, Udell J, Cohen F, Osoegawa K, Hawbecker SK, Noonan DA, Ladner MB, Goodridge D, Trachtenberg EA, Oksenberg J, Erlich HA. High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis. Genes Immun. 2018 Jan 08. PMID: 29307888.
      View in: PubMed
    4. Canto E, Oksenberg J. Multiple sclerosis genetics. Mult Scler. 2018 Jan; 24(1):75-79. PMID: 29307290.
      View in: PubMed
    5. Graves JS, Henry RG, Cree BAC, Lambert-Messerlian G, Greenblatt RM, Waubant E, Cedars MI, Zhu A. Ovarian aging is associated with gray matter volume and disability in women with MS. Neurology. 2018 Jan 16; 90(3):e254-e260. PMID: 29273686.
      View in: PubMed
    6. Baranzini SE, Oksenberg J. The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years. Trends Genet. 2017 Dec; 33(12):960-970. PMID: 28987266.
      View in: PubMed
    7. Amezcua L, Oksenberg J, McCauley JL. MS in self-identified Hispanic/Latino individuals living in the US. Mult Scler J Exp Transl Clin. 2017 Jul-Sep; 3(3):2055217317725103. PMID: 28979795.
      View in: PubMed
    8. Benedek G, Meza-Romero R, Jordan K, Zhang Y, Nguyen H, Kent G, Li J, Siu E, Frazer J, Piecychna M, Du X, Sreih A, Leng L, Wiedrick J, Caillier SJ, Offner H, Oksenberg J, Yadav V, Bourdette D, Bucala R, Vandenbark AA. MIF and D-DT are potential disease severity modifiers in male MS subjects. Proc Natl Acad Sci U S A. 2017 Oct 03; 114(40):E8421-E8429. PMID: 28923927.
      View in: PubMed
    9. Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI, Cardiel MH, Catoggio L, Cervera R, Cucho-Venegas JM, Dahlqvist SR, D'Alfonso S, Da Silva BM, de la Rúa Figueroa I, Doria A, Edberg JC, Endreffy E, Esquivel-Valerio JA, Fortin PR, Freedman BI, Frostegård J, García MA, de la Torre IG, Gilkeson GS, Gladman DD, Gunnarsson I, Guthridge JM, Huggins JL, James JA, Kallenberg CGM, Kamen DL, Karp DR, Kaufman KM, Kottyan LC, Kovács L, Laustrup H, Lauwerys BR, Li QZ, Maradiaga-Ceceña MA, Martín J, McCune JM, McWilliams DR, Merrill JT, Miranda P, Moctezuma JF, Nath SK, Niewold TB, Orozco L, Ortego-Centeno N, Petri M, Pineau CA, Pons-Estel BA, Pope J, Raj P, Ramsey-Goldman R, Reveille JD, Russell LP, Sabio JM, Aguilar-Salinas CA, Scherbarth HR, Scorza R, Seldin MF, Sjöwall C, Svenungsson E, Thompson SD, Toloza SMA, Truedsson L, Tusié-Luna T, Vasconcelos C, Vilá LM, Wallace DJ, Weisman MH, Wither JE, Bhangale T, Oksenberg J, Rioux JD, Gregersen PK, Syvänen AC, Rönnblom L, Criswell LA, Jacob CO, Sivils KL, Tsao BP, Schanberg LE, Behrens TW, Silverman ED, Alarcón-Riquelme ME, Kimberly RP, Harley JB, Wakeland EK, Graham RR, Gaffney PM, Vyse TJ. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun. 2017 07 17; 8:16021. PMID: 28714469.
      View in: PubMed
    10. Isobe N, Oksenberg J, Henry RG. HLA Genetic Risk Burden in Multiple Sclerosis-Reply. JAMA Neurol. 2016 Dec 01; 73(12):1501-1502. PMID: 27775754.
      View in: PubMed
    11. Vigo T, Procaccini C, Ferrara G, Baranzini S, Oksenberg J, Matarese G, Diaspro A, Kerlero de Rosbo N, Uccelli A. IFN-? orchestrates mesenchymal stem cell plasticity through the signal transducer and activator of transcription 1 and 3 and mammalian target of rapamycin pathways. J Allergy Clin Immunol. 2017 May; 139(5):1667-1676. PMID: 27670240.
      View in: PubMed
    12. Didonna A, Cekanaviciute E, Oksenberg J, Baranzini SE. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 08 22; 6:31603. PMID: 27546286.
      View in: PubMed
    13. Long-term evolution of multiple sclerosis disability in the treatment era. Ann Neurol. 2016 Oct; 80(4):499-510. PMID: 27464262.
      View in: PubMed
    14. Norman PJ, Hollenbach JA, Nemat-Gorgani N, Marin WM, Norberg SJ, Ashouri E, Jayaraman J, Wroblewski EE, Trowsdale J, Rajalingam R, Oksenberg J, Chiaroni J, Guethlein LA, Traherne JA, Ronaghi M, Parham P. Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing. Am J Hum Genet. 2016 Aug 04; 99(2):375-91. PMID: 27486779; PMCID: PMC4974113 [Available on 02/04/17].
    15. George MF, Briggs FB, Shao X, Gianfrancesco MA, Kockum I, Harbo HF, Celius EG, Bos SD, Hedström A, Shen L, Bernstein A, Alfredsson L, Hillert J, Olsson T, Patsopoulos NA, De Jager PL, Oturai AB, Søndergaard HB, Sellebjerg F, Sorensen PS, Gomez R, Caillier SJ, Cree BA, Oksenberg J, Hauser SL, D'Alfonso S, Leone MA, Martinelli Boneschi F, Sorosina M, van der Mei I, Taylor BV, Zhou Y, Schaefer C, Barcellos LF. Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies. Neurol Genet. 2016 Aug; 2(4):e87. PMID: 27540591; PMCID: PMC4974846.
    16. Isobe N, Keshavan A, Gourraud PA, Zhu AH, Datta E, Schlaeger R, Caillier SJ, Santaniello A, Lizée A, Himmelstein DS, Baranzini SE, Hollenbach J, Cree BA, Hauser SL, Oksenberg J, Henry RG. Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis. JAMA Neurol. 2016 Jul 01; 73(7):795-802. PMID: 27244296.
      View in: PubMed
    17. Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D'Alfonso S, Demaerel P, Dubois B, Filippi M, Fleischer V, Fontaine B, Gaetano L, Goris A, Graetz C, Gröger A, Groppa S, Hafler DA, Harbo HF, Hemmer B, Jordan K, Kappos L, Kirkish G, Llufriu S, Magon S, Martinelli-Boneschi F, McCauley JL, Montalban X, Mühlau M, Pelletier D, Pattany PM, Pericak-Vance M, Cournu-Rebeix I, Rocca MA, Rovira A, Schlaeger R, Saiz A, Sprenger T, Stecco A, Uitdehaag BMJ, Villoslada P, Wattjes MP, Weiner H, Wuerfel J, Zimmer C, Zipp F. Power estimation for non-standardized multisite studies. Neuroimage. 2016 07 01; 134:281-294. PMID: 27039700.
      View in: PubMed
    18. Khankhanian P, Cozen W, Himmelstein DS, Madireddy L, Din L, van den Berg A, Matsushita T, Glaser SL, Moré JM, Smedby KE, Baranzini SE, Mack TM, Lizée A, de Sanjosé S, Gourraud PA, Nieters A, Hauser SL, Cocco P, Maynadié M, Foretová L, Staines A, Delahaye-Sourdeix M, Li D, Bhatia S, Melbye M, Onel K, Jarrett R, McKay JD, Oksenberg J, Hjalgrim H. Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis. Int J Epidemiol. 2016 06; 45(3):728-40. PMID: 26971321; PMCID: PMC5005944.
    19. Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg J. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8. PMID: 26433934; PMCID: PMC5007634 [Available on 12/15/16].
    20. Bustamante MF, Morcillo-Suárez C, Malhotra S, Rio J, Leyva L, Fernández O, Zettl UK, Killestein J, Brassat D, García-Merino JA, Sánchez AJ, Urcelay E, Alvarez-Lafuente R, Villar LM, Alvarez-Cermeño JC, Farré X, Lechner-Scott J, Vandenbroeck K, Rodríguez-Antigüedad A, Drulovic JS, Martinelli Boneschi F, Chan A, Oksenberg J, Navarro A, Montalban X, Comabella M. Pharmacogenomic study in patients with multiple sclerosis: Responders and nonresponders to IFN-ß. Neurol Neuroimmunol Neuroinflamm. 2015 Oct; 2(5):e154. PMID: 26445728; PMCID: PMC4582905.
    21. Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK, Ban M, Shah TS, Patsopoulos NA, Alfredsson L, Anderson CA, Attfield KE, Baranzini SE, Barrett J, Binder TMC, Booth D, Buck D, Celius EG, Cotsapas C, D'Alfonso S, Dendrou CA, Donnelly P, Dubois B, Fontaine B, Fugger L, Goris A, Gourraud PA, Graetz C, Hemmer B, Hillert J. Class II HLA interactions modulate genetic risk for multiple sclerosis. Nat Genet. 2015 Oct; 47(10):1107-1113. PMID: 26343388.
      View in: PubMed
    22. Khankhanian P, Matsushita T, Madireddy L, Lizée A, Din L, Moré JM, Gourraud PA, Hauser SL, Baranzini SE, Oksenberg J. Genetic contribution to multiple sclerosis risk among Ashkenazi Jews. BMC Med Genet. 2015 Jul 28; 16:55. PMID: 26212423; PMCID: PMC4557862.
    23. Hollenbach JA, Oksenberg J. The immunogenetics of multiple sclerosis: A comprehensive review. J Autoimmun. 2015 Nov; 64:13-25. PMID: 26142251; PMCID: PMC4687745 [Available on 11/01/16].
    24. Tranah GJ, Santaniello A, Caillier SJ, D'Alfonso S, Martinelli Boneschi F, Hauser SL, Oksenberg J. Mitochondrial DNA sequence variation in multiple sclerosis. Neurology. 2015 Jul 28; 85(4):325-30. PMID: 26136518; PMCID: PMC4520811.
    25. Isobe N, Madireddy L, Khankhanian P, Matsushita T, Caillier SJ, Moré JM, Gourraud PA, McCauley JL, Beecham AH. An ImmunoChip study of multiple sclerosis risk in African Americans. Brain. 2015 Jun; 138(Pt 6):1518-30. PMID: 25818868; PMCID: PMC4553906.
    26. Didonna A, Oksenberg J. Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta. 2015 Sep 20; 449:16-22. PMID: 25661088; PMCID: PMC4524789 [Available on 09/20/16].
    27. Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Annese V, Hauser SL, Oksenberg J, Thomsen I, Leslie S. High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat Genet. 2015 Feb; 47(2):172-9. PMID: 25559196.
      View in: PubMed
    28. Nickles D, Madireddy L, Patel N, Isobe N, Miller BL, Baranzini SE, Kramer JH, Oksenberg J. Whole genome sequences of 2 octogenarians with sustained cognitive abilities. Neurobiol Aging. 2015 Mar; 36(3):1435-8. PMID: 25618617; PMCID: PMC4346472.
    29. Gourraud PA, Khankhanian P, Cereb N, Yang SY, Feolo M, Maiers M, Rioux JD, Hauser S, Oksenberg J. HLA diversity in the 1000 genomes dataset. PLoS One. 2014; 9(7):e97282. PMID: 24988075; PMCID: PMC4079705.
    30. Oksenberg J. Decoding multiple sclerosis: an update on genomics and future directions. Expert Rev Neurother. 2013 Dec; 13(12 Suppl):11-9. PMID: 24289837.
      View in: PubMed
    31. Hauser SL, Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg J. Quo vadis? Peering into the future. Ann Neurol. 2013 Dec; 74(6):A5-7. PMID: 24448838.
      View in: PubMed
    32. Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T. Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet. 2013 Nov; 9(11):e1003926. PMID: 24278027; PMCID: PMC3836799.
    33. Goris A, van Setten J, Diekstra F, Ripke S, Patsopoulos NA, Sawcer SJ. No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. Hum Mol Genet. 2014 Apr 01; 23(7):1916-22. PMID: 24234648.
      View in: PubMed
    34. Johnston SC, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg J, Stewart A, Hauser SL. Have the Annals editors added value? Ann Neurol. 2013 Nov; 74(5):A7-9. PMID: 24353220.
      View in: PubMed
    35. Harbo HF, Isobe N, Berg-Hansen P, Bos SD, Caillier SJ, Gustavsen MW, Mero IL, Celius EG, Hauser SL, Oksenberg J, Gourraud PA. Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis. Mult Scler. 2014 May; 20(6):660-8. PMID: 24099750; PMCID: PMC4066985.
    36. Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet. 2013 Nov; 45(11):1353-60. PMID: 24076602.
      View in: PubMed
    37. Hauser SL, Chan JR, Oksenberg J. Multiple sclerosis: Prospects and promise. Ann Neurol. 2013 Sep; 74(3):317-27. PMID: 23955638.
      View in: PubMed
    38. Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Pekarek K, Sobel RA, Hauser SL, Oksenberg J, Zamvil SS, Baranzini SE. Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity. J Exp Med. 2013 Jul 01; 210(7):1301-9. PMID: 23797093; PMCID: PMC3698524.
    39. Rossi S, Studer V, Moscatelli A, Motta C, Coghe G, Fenu G, Caillier S, Buttari F, Mori F, Barbieri F, Castelli M, De Chiara V, Monteleone F, Mancino R, Bernardi G, Baranzini SE, Marrosu MG, Oksenberg J, Centonze D. Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis. PLoS One. 2013; 8(6):e67357. PMID: 23840674; PMCID: PMC3696106.
    40. Isobe N, Gourraud PA, Harbo HF, Caillier SJ, Santaniello A, Khankhanian P, Maiers M, Spellman S, Cereb N, Yang S, Pando MJ, Piccio L, Cross AH, De Jager PL, Cree BA, Hauser SL, Oksenberg J. Genetic risk variants in African Americans with multiple sclerosis. Neurology. 2013 Jul 16; 81(3):219-27. PMID: 23771490; PMCID: PMC3770164.
    41. Nickles D, Chen HP, Li MM, Khankhanian P, Madireddy L, Caillier SJ, Santaniello A, Cree BA, Pelletier D, Hauser SL, Oksenberg J, Baranzini SE. Blood RNA profiling in a large cohort of multiple sclerosis patients and healthy controls. Hum Mol Genet. 2013 Oct 15; 22(20):4194-205. PMID: 23748426; PMCID: PMC3781642.
    42. Swaminathan B, Cuapio A, Alloza I, Matesanz F, Alcina A, García-Barcina M, Fedetz M, Fernández O, Lucas M, Orpez T, Pinto-Medel MJ, Otaegui D, Olascoaga J, Urcelay E, Ortiz MA, Arroyo R, Oksenberg J, Antigüedad A, Tolosa E, Vandenbroeck K. Fine mapping and functional analysis of the multiple sclerosis risk gene CD6. PLoS One. 2013; 8(4):e62376. PMID: 23638056; PMCID: PMC3634811.
    43. Ban M, Caillier S, Mero IL, Myhr KM, Celius EG, Aarseth J, Torkildsen Ø, Harbo HF, Oksenberg J, Hauser SL, Sawcer S, Compston A. No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis. Ann Neurol. 2013 Mar; 73(3):430-2. PMID: 23444327; PMCID: PMC3631291.
    44. Gourraud PA, Sdika M, Khankhanian P, Henry RG, Beheshtian A, Matthews PM, Hauser SL, Oksenberg J, Pelletier D, Baranzini SE. A genome-wide association study of brain lesion distribution in multiple sclerosis. Brain. 2013 Apr; 136(Pt 4):1012-24. PMID: 23412934; PMCID: PMC3613709.
    45. Nickles D, Madireddy L, Yang S, Khankhanian P, Lincoln S, Hauser SL, Oksenberg J, Baranzini SE. In depth comparison of an individual's DNA and its lymphoblastoid cell line using whole genome sequencing. BMC Genomics. 2012 Sep 14; 13:477. PMID: 22974163; PMCID: PMC3473256.
    46. Su SY, Kasberger J, Baranzini S, Byerley W, Liao W, Oksenberg J, Sherr E, Jorgenson E. Detection of identity by descent using next-generation whole genome sequencing data. BMC Bioinformatics. 2012 Jun 06; 13:121. PMID: 22672699; PMCID: PMC3403908.
    47. Hedges DJ, Hamilton-Nelson KL, Sacharow SJ, Nations L, Beecham GW, Kozhekbaeva ZM, Butler BL, Cukier HN, Whitehead PL, Ma D, Jaworski JM, Nathanson L, Lee JM, Hauser SL, Oksenberg J, Cuccaro ML, Haines JL, Gilbert JR, Pericak-Vance MA. Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci. Mol Autism. 2012 Apr 02; 3:2. PMID: 22472195; PMCID: PMC3352055.
    48. Stewart AF, Ferriero DM, Josephson SA, Lowenstein DH, Messing RO, Oksenberg J, Johnston SC, Hauser SL. Fighting decision fatigue. Ann Neurol. 2012 Jan; 71(1):A5-A15. PMID: 22275264.
      View in: PubMed
    49. Oksenberg J, Hauser SL. Decoding multiple sclerosis. Ann Neurol. 2011 Dec; 70(6):A5-7. PMID: 22190375.
      View in: PubMed
    50. Patsopoulos NA. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol. 2011 Dec; 70(6):897-912. PMID: 22190364; PMCID: PMC3247076.
    51. Glanville J, Kuo TC, von Büdingen HC, Guey L, Berka J, Sundar PD, Huerta G, Mehta GR, Oksenberg J, Hauser SL, Cox DR, Rajpal A, Pons J. Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20066-71. PMID: 22123975; PMCID: PMC3250199.
    52. Funk WD, Labat I, Sampathkumar J, Gourraud PA, Oksenberg J, Rosler E, Steiger D, Sheibani N, Caillier S, Stache-Crain B, Johnson JA, Meisner L, Lacher MD, Chapman KB, Park MJ, Shin KJ, Drmanac R, West MD. Evaluating the genomic and sequence integrity of human ES cell lines; comparison to normal genomes. Stem Cell Res. 2012 Mar; 8(2):154-64. PMID: 22265736.
      View in: PubMed
    53. Malhotra S, Morcillo-Suárez C, Brassat D, Goertsches R, Lechner-Scott J, Urcelay E, Fernández O, Drulovic J, García-Merino A, Martinelli Boneschi F, Chan A, Vandenbroeck K, Navarro A, Bustamante MF, Río J, Akkad DA, Giacalone G, Sánchez AJ, Leyva L, Alvarez-Lafuente R, Zettl UK, Oksenberg J, Montalban X, Comabella M. IL28B polymorphisms are not associated with the response to interferon-ß in multiple sclerosis. J Neuroimmunol. 2011 Oct 28; 239(1-2):101-4. PMID: 21889215.
      View in: PubMed
    54. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011 Aug 10; 476(7359):214-9. PMID: 21833088.
      View in: PubMed
    55. Gelfand JM, Cree BA, McElroy J, Oksenberg J, Green R, Mowry EM, Miller JW, Hauser SL, Green AJ. Vitamin D in African Americans with multiple sclerosis. Neurology. 2011 May 24; 76(21):1824-30. PMID: 21606454; PMCID: PMC3100123.
    56. McElroy JP, Oksenberg J. Multiple sclerosis genetics 2010. Neurol Clin. 2011 May; 29(2):219-31. PMID: 21439438.
      View in: PubMed
    57. Couturier N, Bucciarelli F, Nurtdinov RN, Debouverie M, Lebrun-Frenay C, Defer G, Moreau T, Confavreux C, Vukusic S, Cournu-Rebeix I, Goertsches RH, Zettl UK, Comabella M, Montalban X, Rieckmann P, Weber F, Müller-Myhsok B, Edan G, Fontaine B, Mars LT, Saoudi A, Oksenberg J, Clanet M, Liblau RS, Brassat D. Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility. Brain. 2011 Mar; 134(Pt 3):693-703. PMID: 21354972.
      View in: PubMed
    58. Bush WS, McCauley JL, DeJager PL, Dudek SM, Hafler DA, Gibson RA, Matthews PM, Kappos L, Naegelin Y, Polman CH, Hauser SL, Oksenberg J, Haines JL, Ritchie MD. A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility. Genes Immun. 2011 Jul; 12(5):335-40. PMID: 21346779; PMCID: PMC3136581.
    59. Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, Kappos L, Polman CH. Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Med. 2011 Jan 18; 3(1):3. PMID: 21244703; PMCID: PMC3092088.
    60. Gourraud PA, McElroy JP, Caillier SJ, Johnson BA, Santaniello A, Hauser SL, Oksenberg J. Aggregation of multiple sclerosis genetic risk variants in multiple and single case families. Ann Neurol. 2011 Jan; 69(1):65-74. PMID: 21280076; PMCID: PMC3511846.
    61. Khankhanian P, Gourraud PA, Caillier SJ, Santaniello A, Hauser SL, Baranzini SE, Oksenberg J. Genetic variation in the odorant receptors family 13 and the mhc loci influence mate selection in a multiple sclerosis dataset. BMC Genomics. 2010 Nov 10; 11:626. PMID: 21067613; PMCID: PMC3091764.
    62. Camiña-Tato M, Morcillo-Suárez C, Bustamante MF, Ortega I, Navarro A, Muntasell A, López-Botet M, Sánchez A, Carmona P, Julià E, Tortola MT, Audí L, Oksenberg J, Martin R, Montalban X, Comabella M. Gender-associated differences of perforin polymorphisms in the susceptibility to multiple sclerosis. J Immunol. 2010 Nov 01; 185(9):5392-404. PMID: 20921521.
      View in: PubMed
    63. Dumitrescu L, Ritchie MD, Brown-Gentry K, Pulley JM, Basford M, Denny JC, Oksenberg J, Roden DM, Haines JL, Crawford DC. Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records. Genet Med. 2010 Oct; 12(10):648-50. PMID: 20733501; PMCID: PMC2952033.
    64. Oksenberg J, Klitz W. Immunogenetics in the Holy Land. Tissue Antigens. 2010 Dec; 76(6):440-1. PMID: 20860584.
      View in: PubMed
    65. Baranzini SE, Srinivasan R, Khankhanian P, Okuda DT, Nelson SJ, Matthews PM, Hauser SL, Oksenberg J, Pelletier D. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. Brain. 2010 Sep; 133(9):2603-11. PMID: 20802204; PMCID: PMC2929334.
    66. Briggs FB, Bartlett SE, Goldstein BA, Wang J, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg J, Sawcer SJ, Pericak-Vance MA, Haines JL. Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. Hum Mol Genet. 2010 Nov 01; 19(21):4286-95. PMID: 20699326; PMCID: PMC2951862.
    67. Oksenberg J, Baranzini SE. Multiple sclerosis genetics--is the glass half full, or half empty? Nat Rev Neurol. 2010 Aug; 6(8):429-37. PMID: 20625377.
      View in: PubMed
    68. Cree BA, Rioux JD, McCauley JL, Gourraud PA, Goyette P, McElroy J, De Jager P, Santaniello A, Vyse TJ, Gregersen PK, Mirel D, Hafler DA, Haines JL, Pericak-Vance MA, Compston A, Sawcer SJ, Oksenberg J, Hauser SL. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. PLoS One. 2010 Jun 25; 5(6):e11296. PMID: 20593013.
      View in: PubMed
    69. Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg J, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF. Variation within DNA repair pathway genes and risk of multiple sclerosis. Am J Epidemiol. 2010 Jul 15; 172(2):217-24. PMID: 20522537; PMCID: PMC3658128.
    70. Oksenberg J, Hauser SL. Mapping the human genome with newfound precision. Ann Neurol. 2010 Jun; 67(6):A8-A10. PMID: 20517930.
      View in: PubMed
    71. Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nat Genet. 2010 Jun; 42(6):469-70; author reply 470-1. PMID: 20502484; PMCID: PMC3109873.
    72. McElroy JP, Cree BA, Caillier SJ, Gregersen PK, Herbert J, Khan OA, Freudenberg J, Lee A, Bridges SL, Hauser SL, Oksenberg J, Gourraud PA. Refining the association of MHC with multiple sclerosis in African Americans. Hum Mol Genet. 2010 Aug 01; 19(15):3080-8. PMID: 20466734; PMCID: PMC2901136.
    73. Mowry EM, Krupp LB, Milazzo M, Chabas D, Strober JB, Belman AL, McDonald JC, Oksenberg J, Bacchetti P, Waubant E. Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. Ann Neurol. 2010 May; 67(5):618-24. PMID: 20437559.
      View in: PubMed
    74. Baranzini SE, Mudge J, van Velkinburgh JC, Khankhanian P, Khrebtukova I, Miller NA, Zhang L, Farmer AD, Bell CJ, Kim RW, May GD, Woodward JE, Caillier SJ, McElroy JP, Gomez R, Pando MJ, Clendenen LE, Ganusova EE, Schilkey FD, Ramaraj T, Khan OA, Huntley JJ, Luo S, Kwok PY, Wu TD, Schroth GP, Oksenberg J, Hauser SL, Kingsmore SF. Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature. 2010 Apr 29; 464(7293):1351-6. PMID: 20428171; PMCID: PMC2862593.
    75. Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come. Am J Hum Genet. 2010 Apr 09; 86(4):621-5. PMID: 20362272.
      View in: PubMed
    76. Bronson PG, Caillier S, Ramsay PP, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Sawcer SJ, Pericak-Vance MA, Haines JL. CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. Hum Mol Genet. 2010 Jun 01; 19(11):2331-40. PMID: 20211854; PMCID: PMC2865376.
    77. Zuvich RL, McCauley JL, Oksenberg J, Sawcer SJ, De Jager PL. Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility. Hum Genet. 2010 Mar; 127(5):525-35. PMID: 20112030.
      View in: PubMed
    78. Pappas DJ, Oksenberg J. Multiple sclerosis pharmacogenomics: maximizing efficacy of therapy. Neurology. 2010 Jan 05; 74 Suppl 1:S62-9. PMID: 20038765.
      View in: PubMed
    79. Hauser SL, Johnston SC, Ferriero DM, Lowenstein DH, Josephson SA, Messing RO, Oksenberg J, Stewart AF. Status report: the Annals in 2010. Ann Neurol. 2010 Jan; 67(1):A5-12. PMID: 20186980.
      View in: PubMed
    80. Bryc K, Auton A, Nelson MR, Oksenberg J, Hauser SL, Williams S, Froment A, Bodo JM, Wambebe C, Tishkoff SA, Bustamante CD. Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):786-91. PMID: 20080753; PMCID: PMC2818934.
    81. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18680-5. PMID: 19846760; PMCID: PMC2773992.
    82. Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe'er I, Dudbridge F, Holmans PA, Whittemore AS, Mowry BJ, Olincy A, Amin F, Cloninger CR, Silverman JM, Buccola NG, Byerley WF, Black DW, Crowe RR, Oksenberg J, Mirel DB, Kendler KS, Freedman R, Gejman PV. Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature. 2009 Aug 06; 460(7256):753-7. PMID: 19571809.
      View in: PubMed
    83. De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet. 2009 Jul; 41(7):776-82. PMID: 19525953; PMCID: PMC2757648.
    84. Vandenbroeck K, Comabella M, Tolosa E, Goertsches R, Brassat D, Hintzen R, Infante-Duarte C, Favorov A, Escorza S, Palacios R, Oksenberg J, Villoslada P. United Europeans for development of pharmacogenomics in multiple sclerosis network. Pharmacogenomics. 2009 May; 10(5):885-94. PMID: 19450134.
      View in: PubMed
    85. McElroy JP, Nelson MR, Caillier SJ, Oksenberg J. Copy number variation in African Americans. BMC Genet. 2009 Mar 24; 10:15. PMID: 19317893; PMCID: PMC2674062.
    86. Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, Ingram G, Booth DR, Heard RN, Stewart GJ, Bogaert E, Dubois B, Harbo HF, Celius EG, Spurkland A, Strange R, Hawkins C, Robertson NP, Dudbridge F, Wason J, De Jager PL, Hafler D, Rioux JD, Ivinson AJ, McCauley JL, Pericak-Vance M, Oksenberg J, Hauser SL, Sexton D, Haines J, Sawcer S. Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. Eur J Hum Genet. 2009 Oct; 17(10):1309-13. PMID: 19293837.
      View in: PubMed
    87. Baranzini SE, Galwey NW, Wang J, Khankhanian P, Lindberg R, Pelletier D, Wu W, Uitdehaag BM, Kappos L. Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet. 2009 Jun 01; 18(11):2078-90. PMID: 19286671; PMCID: PMC2678928.
    88. De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg J, Hafler DA. The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5264-9. PMID: 19237575; PMCID: PMC2664005.
    89. Stüve O, Korth C, Gabatto P, Cameron EM, Hu W, Eagar TN, Monson NL, Frohman EM, Racke MK, Zabetian CP, Oksenberg J. Genetic polymorphism at codon 129 of the prion protein gene is not associated with multiple sclerosis. Arch Neurol. 2009 Feb; 66(2):280-1. PMID: 19204171.
      View in: PubMed
    90. Cree BA, Reich DE, Khan O, De Jager PL, Nakashima I, Takahashi T, Bar-Or A, Tong C, Hauser SL, Oksenberg J. Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA. Arch Neurol. 2009 Feb; 66(2):226-33. PMID: 19204159; PMCID: PMC4334456.
    91. Hermiston ML, Zikherman J, Tan AL, Lam VC, Cresalia NM, Oksenberg N, Goren N, Brassat D, Oksenberg J, Weiss A. Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses. Proc Natl Acad Sci U S A. 2009 Jan 13; 106(2):546-51. PMID: 19129486; PMCID: PMC2626740.
    92. Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg J, Hauser SL, Compston A, Sawcer S. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet. 2009 Jan; 5(1):e1000322. PMID: 19119414.
      View in: PubMed
    93. Ding B, Padyukov L, Lundström E, Seielstad M, Plenge RM, Oksenberg J, Gregersen PK, Alfredsson L, Klareskog L. Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region. Arthritis Rheum. 2009 Jan; 60(1):30-8. PMID: 19116921; PMCID: PMC2874319.
    94. Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, Barkhof F, Radue EW, Lindberg RL, Uitdehaag BM, Johnson MR, Angelakopoulou A, Hall L, Richardson JC, Prinjha RK, Gass A, Geurts JJ, Kragt J, Sombekke M, Vrenken H, Qualley P, Lincoln RR, Gomez R, Caillier SJ, George MF, Mousavi H, Guerrero R, Okuda DT, Cree BA, Green AJ, Waubant E, Goodin DS, Pelletier D, Matthews PM, Hauser SL, Kappos L, Polman CH, Oksenberg J. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet. 2009 Feb 15; 18(4):767-78. PMID: 19010793; PMCID: PMC4334814.
    95. Comabella M, Río J, Espejo C, Ruiz de Villa M, Al-Zayat H, Nos C, Deisenhammer F, Baranzini SE, Nonell L, López C, Julià E, Oksenberg J, Montalban X. Changes in matrix metalloproteinases and their inhibitors during interferon-beta treatment in multiple sclerosis. Clin Immunol. 2009 Feb; 130(2):145-50. PMID: 18945642.
      View in: PubMed
    96. Caillier SJ, Briggs F, Cree BA, Baranzini SE, Fernandez-Viña M, Ramsay PP, Khan O, Royal W, Hauser SL, Barcellos LF, Oksenberg J. Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis. J Immunol. 2008 Oct 15; 181(8):5473-80. PMID: 18832704; PMCID: PMC4346327.
    97. Nelson MR, Bryc K, King KS, Indap A, Boyko AR, Novembre J, Briley LP, Maruyama Y, Waterworth DM, Waeber G, Vollenweider P, Oksenberg J, Hauser SL, Stirnadel HA, Kooner JS, Chambers JC, Jones B, Mooser V, Bustamante CD, Roses AD, Burns DK, Ehm MG, Lai EH. The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research. Am J Hum Genet. 2008 Sep; 83(3):347-58. PMID: 18760391; PMCID: PMC2556436.
    98. Corvol JC, Pelletier D, Henry RG, Caillier SJ, Wang J, Pappas D, Casazza S, Okuda DT, Hauser SL, Oksenberg J, Baranzini SE. Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11839-44. PMID: 18689680; PMCID: PMC2504481.
    99. Oksenberg J, Baranzini SE, Sawcer S, Hauser SL. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat Rev Genet. 2008 Jul; 9(7):516-26. PMID: 18542080.
      View in: PubMed
    100. Rhodes B, Morris DL, Subrahmanyan L, Aubin C, de Leon CF, Kelly JF, Evans DA, Whittaker JC, Oksenberg J, De Jager PL, Vyse TJ. Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach. Hum Genet. 2008 Jul; 123(6):633-42. PMID: 18500540; PMCID: PMC2630773.
    101. Long BR, Ndhlovu LC, Oksenberg J, Lanier LL, Hecht FM, Nixon DF, Barbour JD. Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection. J Virol. 2008 May; 82(10):4785-92. PMID: 18305035; PMCID: PMC2346752.
    102. Oksenberg J, Hauser SL. Neurogenetics in the Annals: dealing with complexity. Ann Neurol. 2008 Feb; 63(2):A11-4. PMID: 18306395.
      View in: PubMed
    103. Goertsches R, Baranzini SE, Morcillo C, Nos C, Camiña M, Oksenberg J, Montalban X, Comabella M. Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis. Mult Scler. 2008 Apr; 14(3):412-4. PMID: 18208870.
      View in: PubMed
    104. Byun E, Caillier SJ, Montalban X, Villoslada P, Fernández O, Brassat D, Comabella M, Wang J, Barcellos LF, Baranzini SE, Oksenberg J. Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis. Arch Neurol. 2008 Mar; 65(3):337-44. PMID: 18195134.
      View in: PubMed
    105. Begovich AB, Chang M, Caillier SJ, Lew D, Catanese JJ, Wang J, Hauser SL, Oksenberg J. The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis. Hum Immunol. 2007 Nov; 68(11):934-7. PMID: 18082575.
      View in: PubMed
    106. Otaegui D, Mostafavi S, Bernard CC, Lopez de Munain A, Mousavi P, Oksenberg J, Baranzini SE. Increased transcriptional activity of milk-related genes following the active phase of experimental autoimmune encephalomyelitis and multiple sclerosis. J Immunol. 2007 Sep 15; 179(6):4074-82. PMID: 17785846.
      View in: PubMed
    107. McCauley JL, Kenealy SJ, Margulies EH, Schnetz-Boutaud N, Gregory SG, Hauser SL, Oksenberg J, Pericak-Vance MA, Haines JL, Mortlock DP. SNPs in Multi-species Conserved Sequences (MCS) as useful markers in association studies: a practical approach. BMC Genomics. 2007 Aug 06; 8:266. PMID: 17683615; PMCID: PMC1959193.
    108. Gregory SG, Schmidt S, Seth P, Oksenberg J, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet. 2007 Sep; 39(9):1083-91. PMID: 17660817.
      View in: PubMed
    109. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med. 2007 Aug 30; 357(9):851-62. PMID: 17660530.
      View in: PubMed
    110. Sriram U, Wong M, Caillier SJ, Hecht FM, Elkins MK, Levy JA, Oksenberg J, Baranzini SE. Quantitative longitudinal analysis of T cell receptor repertoire expression in HIV-infected patients on antiretroviral and interleukin-2 therapy. AIDS Res Hum Retroviruses. 2007 May; 23(5):741-7. PMID: 17531001.
      View in: PubMed
    111. Fernald GH, Knott S, Pachner A, Caillier SJ, Narayan K, Oksenberg J, Mousavi P, Baranzini SE. Genome-wide network analysis reveals the global properties of IFN-beta immediate transcriptional effects in humans. J Immunol. 2007 Apr 15; 178(8):5076-85. PMID: 17404290.
      View in: PubMed
    112. Johnston SC, Lowenstein DH, Ferriero DM, Messing RO, Oksenberg J, Hauser SL. Early editorial manuscript screening versus obligate peer review: a randomized trial. Ann Neurol. 2007 Apr; 61(4):A10-2. PMID: 17444512.
      View in: PubMed
    113. Barbour JD, Sriram U, Caillier SJ, Levy JA, Hecht FM, Oksenberg J. Synergy or independence? Deciphering the interaction of HLA Class I and NK cell KIR alleles in early HIV-1 disease progression. PLoS Pathog. 2007 Apr; 3(4):e43. PMID: 17447840; PMCID: PMC1853116.
    114. Pedemonte E, Benvenuto F, Casazza S, Mancardi G, Oksenberg J, Uccelli A, Baranzini SE. The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse. BMC Genomics. 2007 Mar 06; 8:65. PMID: 17341312; PMCID: PMC1821333.
    115. Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne J, Beck S, Trowsdale J, Caillier SJ, Ivinson AJ, Green T, Pobywajlo S, Lander ES, Pericak-Vance MA, Haines JL, Daly MJ, Oksenberg J, Hauser SL, Compston A, Hafler DA, Rioux JD, Sawcer S. A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol. 2007 Mar; 61(3):228-36. PMID: 17252545; PMCID: PMC2737610.
    116. Dunn SE, Ousman SS, Sobel RA, Zuniga L, Baranzini SE, Youssef S, Crowell A, Loh J, Oksenberg J, Steinman L. Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. J Exp Med. 2007 Feb 19; 204(2):321-30. PMID: 17261635; PMCID: PMC2118721.
    117. Barcellos LF, Kamdar BB, Ramsay PP, DeLoa C, Lincoln RR, Caillier S, Schmidt S, Haines JL, Pericak-Vance MA, Oksenberg J, Hauser SL. Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. Lancet Neurol. 2006 Nov; 5(11):924-31. PMID: 17052659.
      View in: PubMed
    118. Hauser SL, Oksenberg J. The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron. 2006 Oct 05; 52(1):61-76. PMID: 17015227.
      View in: PubMed
    119. Motsinger AA, Brassat D, Caillier SJ, Erlich HA, Walker K, Steiner LL, Barcellos LF, Pericak-Vance MA, Schmidt S, Gregory S, Hauser SL, Haines JL, Oksenberg J, Ritchie MD. Complex gene-gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes. Neurogenetics. 2007 Jan; 8(1):11-20. PMID: 17024427.
      View in: PubMed
    120. Barcellos LF, Sawcer S, Ramsay PP, Baranzini SE, Thomson G, Briggs F, Cree BC, Begovich AB, Villoslada P, Montalban X, Uccelli A, Savettieri G, Lincoln RR, DeLoa C, Haines JL, Pericak-Vance MA, Compston A, Hauser SL, Oksenberg J. Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet. 2006 Sep 15; 15(18):2813-24. PMID: 16905561.
      View in: PubMed
    121. Traherne JA, Barcellos LF, Sawcer SJ, Compston A, Ramsay PP, Hauser SL, Oksenberg J, Trowsdale J. Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15. Hum Mol Genet. 2006 Jan 01; 15(1):155-61. PMID: 16321988.
      View in: PubMed
    122. Fernald GH, Yeh RF, Hauser SL, Oksenberg J, Baranzini SE. Mapping gene activity in complex disorders: Integration of expression and genomic scans for multiple sclerosis. J Neuroimmunol. 2005 Oct; 167(1-2):157-69. PMID: 16129498.
      View in: PubMed
    123. Reich D, Patterson N, De Jager PL, McDonald GJ, Waliszewska A, Tandon A, Lincoln RR, DeLoa C, Fruhan SA, Cabre P, Bera O, Semana G, Kelly MA, Francis DA, Ardlie K, Khan O, Cree BA, Hauser SL, Oksenberg J, Hafler DA. A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet. 2005 Oct; 37(10):1113-8. PMID: 16186815.
      View in: PubMed
    124. Sawcer S, Ban M, Maranian M, Yeo TW, Compston A, Kirby A, Daly MJ, De Jager PL, Walsh E, Lander ES, Rioux JD, Hafler DA, Ivinson A, Rimmler J, Gregory SG, Schmidt S, Pericak-Vance MA, Akesson E, Hillert J, Datta P, Oturai A, Ryder LP, Harbo HF, Spurkland A, Myhr KM, Laaksonen M, Booth D, Heard R, Stewart G, Lincoln R, Barcellos LF, Hauser SL, Oksenberg J, Kenealy SJ, Haines JL. A high-density screen for linkage in multiple sclerosis. Am J Hum Genet. 2005 Sep; 77(3):454-67. PMID: 16080120; PMCID: PMC1226210.
    125. Baranzini SE, Bernard CC, Oksenberg J. Modular transcriptional activity characterizes the initiation and progression of autoimmune encephalomyelitis. J Immunol. 2005 Jun 01; 174(11):7412-22. PMID: 15905590.
      View in: PubMed
    126. Baranzini SE, Oksenberg J. Genomics and new targets for multiple sclerosis. Pharmacogenomics. 2005 Mar; 6(2):151-61. PMID: 15882133.
      View in: PubMed
    127. Oksenberg J, Hauser SL. Genetics of multiple sclerosis. Neurol Clin. 2005 Feb; 23(1):61-75, vi. PMID: 15661088.
      View in: PubMed
    128. Begovich AB, Caillier SJ, Alexander HC, Penko JM, Hauser SL, Barcellos LF, Oksenberg J. The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis. Am J Hum Genet. 2005 Jan; 76(1):184-7. PMID: 15580548; PMCID: PMC1196423.
    129. Baranzini SE, Mousavi P, Rio J, Caillier SJ, Stillman A, Villoslada P, Wyatt MM, Comabella M, Greller LD, Somogyi R, Montalban X, Oksenberg J. Transcription-based prediction of response to IFNbeta using supervised computational methods. PLoS Biol. 2005 Jan; 3(1):e2. PMID: 15630474; PMCID: PMC539058.
    130. Oksenberg J, Hauser SL. Re: GAMES issue. J Neuroimmunol. 2004 Aug; 153(1-2):1-2. PMID: 15338519.
      View in: PubMed
    131. Sawcer SJ, Maranian M, Singlehurst S, Yeo T, Compston A, Daly MJ, De Jager PL, Gabriel S, Hafler DA, Ivinson AJ, Lander ES, Rioux JD, Walsh E, Gregory SG, Schmidt S, Pericak-Vance MA, Barcellos L, Hauser SL, Oksenberg J, Kenealy SJ, Haines JL. Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Hum Mol Genet. 2004 Sep 01; 13(17):1943-9. PMID: 15238506.
      View in: PubMed
    132. Barcellos LF, Begovich AB, Reynolds RL, Caillier SJ, Brassat D, Schmidt S, Grams SE, Walker K, Steiner LL, Cree BA, Stillman A, Lincoln RR, Pericak-Vance MA, Haines JL, Erlich HA, Hauser SL, Oksenberg J. Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. Ann Neurol. 2004 Jun; 55(6):793-800. PMID: 15174013.
      View in: PubMed
    133. Villoslada P, Oksenberg J, Rio J, Montalban X. Clinical characteristics of responders to interferon therapy for relapsing MS. Neurology. 2004 May 11; 62(9):1653; author reply 1653. PMID: 15136712.
      View in: PubMed
    134. Villoslada P, Barcellos LF, Oksenberg J. Chromosome 7q21-22 and multiple sclerosis. J Neuroimmunol. 2004 May; 150(1-2):1-2. PMID: 15081242.
      View in: PubMed
    135. Patterson N, Hattangadi N, Lane B, Lohmueller KE, Hafler DA, Oksenberg J, Hauser SL, Smith MW, O'Brien SJ, Altshuler D, Daly MJ, Reich D. Methods for high-density admixture mapping of disease genes. Am J Hum Genet. 2004 May; 74(5):979-1000. PMID: 15088269; PMCID: PMC1181990.
    136. Oksenberg J, Barcellos LF, Cree BA, Baranzini SE, Bugawan TL, Khan O, Lincoln RR, Swerdlin A, Mignot E, Lin L, Goodin D, Erlich HA, Schmidt S, Thomson G, Reich DE, Pericak-Vance MA, Haines JL, Hauser SL. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet. 2004 Jan; 74(1):160-7. PMID: 14669136; PMCID: PMC1181903.
    137. Pericak-Vance MA, Rimmler JB, Haines JL, Garcia ME, Oksenberg J, Barcellos LF, Lincoln R, Hauser SL, Cournu-Rebeix I, Azoulay-Cayla A, Lyon-Caen O, Fontaine B, Duhamel E, Coppin H, Brassat D, Roth MP, Clanet M, Alizadeh M, Yaouanq J, Quelvennec E, Semana G, Edan G, Babron MC, Genin E, Clerget-Darpoux F. Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study. Neurogenetics. 2004 Feb; 5(1):45-8. PMID: 14595552.
      View in: PubMed
    138. Haines JL, Bradford Y, Garcia ME, Reed AD, Neumeister E, Pericak-Vance MA, Rimmler JB, Menold MM, Martin ER, Oksenberg J, Barcellos LF, Lincoln R, Hauser SL. Multiple susceptibility loci for multiple sclerosis. Hum Mol Genet. 2002 Sep 15; 11(19):2251-6. PMID: 12217953.
      View in: PubMed
    139. Haukim N, Bidwell JL, Smith AJ, Keen LJ, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases, supplement 2. Genes Immun. 2002 Sep; 3(6):313-30. PMID: 12209358.
      View in: PubMed
    140. Villoslada P, Barcellos LF, Rio J, Begovich AB, Tintore M, Sastre-Garriga J, Baranzini SE, Casquero P, Hauser SL, Montalban X, Oksenberg J. The HLA locus and multiple sclerosis in Spain. Role in disease susceptibility, clinical course and response to interferon-beta. J Neuroimmunol. 2002 Sep; 130(1-2):194-201. PMID: 12225902.
      View in: PubMed
    141. Baranzini SE, Laxer K, Bollen A, Oksenberg J. Gene expression analysis reveals altered brain transcription of glutamate receptors and inflammatory genes in a patient with chronic focal (Rasmussen's) encephalitis. J Neuroimmunol. 2002 Jul; 128(1-2):9-15. PMID: 12098505.
      View in: PubMed
    142. Lock C, Hermans G, Pedotti R, Brendolan A, Schadt E, Garren H, Langer-Gould A, Strober S, Cannella B, Allard J, Klonowski P, Austin A, Lad N, Kaminski N, Galli SJ, Oksenberg J, Raine CS, Heller R, Steinman L. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med. 2002 May; 8(5):500-8. PMID: 11984595.
      View in: PubMed
    143. Steinman L, Martin R, Bernard C, Conlon P, Oksenberg J. Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy. Annu Rev Neurosci. 2002; 25:491-505. PMID: 12052918.
      View in: PubMed
    144. Baranzini SE, Oksenberg J, Hauser SL. New insights into the genetics of multiple sclerosis. J Rehabil Res Dev. 2002 Mar-Apr; 39(2):201-9. PMID: 12051464.
      View in: PubMed
    145. Schmidt S, Barcellos LF, DeSombre K, Rimmler JB, Lincoln RR, Bucher P, Saunders AM, Lai E, Martin ER, Vance JM, Oksenberg J, Hauser SL, Pericak-Vance MA, Haines JL. Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis. Am J Hum Genet. 2002 Mar; 70(3):708-17. PMID: 11836653; PMCID: PMC384947.
    146. Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases, supplement 1. Genes Immun. 2001 Apr; 2(2):61-70. PMID: 11393658.
      View in: PubMed
    147. Lock C, Oksenberg J, Steinman L. The role of TNFalpha and lymphotoxin in demyelinating disease. Ann Rheum Dis. 1999 Nov; 58 Suppl 1:I121-8. PMID: 10577988; PMCID: PMC1766588.
    148. Bidwell J, Keen L, Gallagher G, Kimberly R, Huizinga T, McDermott MF, Oksenberg J, McNicholl J, Pociot F, Hardt C, D'Alfonso S. Cytokine gene polymorphism in human disease: on-line databases. Genes Immun. 1999 Sep; 1(1):3-19. PMID: 11197303.
      View in: PubMed
    149. Sherritt MA, Oksenberg J, de Rosbo NK, Bernard CC. Influence of HLA-DR2, HLA-DPw4, and T cell receptor alpha chain genes on the susceptibility to multiple sclerosis. Int Immunol. 1992 Feb; 4(2):177-81. PMID: 1352460.
      View in: PubMed
    150. Cohen N, Shaw S, Amar A, Oksenberg J, Brautbar C. HLA-linked SB antigens in Israel. Population study, analysis of homozygous typing cells and generation of local SB reagents. Tissue Antigens. 1984 Aug; 24(2):113-20. PMID: 6593897.
      View in: PubMed
    151. Oksenberg J, Amar A, Cohen N, Grosse-Wilde H, Cohen I, Sharon R, Nelken D, Brautbar C. HLA-D "BG" in Israel. A Japanese related allele population and family study. Tissue Antigens. 1983 Apr; 21(4):271-80. PMID: 6407145.
      View in: PubMed
    152. Persitz E, Oksenberg J, Amar A, Margalioth EJ, Cohen O, Brautbar C. Histocompatibility antigens, mixed lymphocyte reactivity and severe preeclampsia in Israel. Gynecol Obstet Invest. 1983; 16(5):283-91. PMID: 6227533.
      View in: PubMed
    153. Amar A, Oksenberg J, Cohen N, Cohen I, Brautbar C. HLA-D locus in Israel. Characterization of 14 local HTC's and a population study. Tissue Antigens. 1982 Sep; 20(3):198-207. PMID: 6215743.
      View in: PubMed
    154. Brautbar C, Amar A, Cohen N, Oksenberg J, Cohen I, Kahana E, Bloch D, Alter M, Grosse-Wilde H. HLA-D typing in multiple sclerosis: Israelis tested with European homozygous typing cells. Tissue Antigens. 1982 Mar; 19(3):189-97. PMID: 6953617.
      View in: PubMed