Argentina Lario Lago, PhD

Title(s)Associate Researcher, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane, #193D
San Francisco CA 94158
Phone415-502-3773
Pronounsshe/her/hers
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    Collapse Biography 
    Collapse Education and Training
    School of Biology, Universidad Autónoma de Madrid, Madrid, SpainBSc2009Biology
    School of Sciences, Universidad Autónoma de Madrid, Madrid, SpainMSc2010Molecular Biosciences
    CBMSO UAM/CSIC, Universidad Autónoma de Madrid, Madrid, SpainPhD2014Molecular Neuroscience

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    Collapse Overview
    Argentina is a biologist with a PhD degree in molecular neuroscience from the Universidad Autonoma de Madrid, Spain. Her doctoral work focused on microtubule-dependent transport of AMPA receptors during synaptic plasticity processes in hippocampal neurons. To address this question, she used a multidisciplinary approach combining a plethora of techniques from biochemistry to imaging and electrophysiology, amongst others. During her postdoc, she continued working on the molecular mechanisms underlying synaptic plasticity using electrophysiology as her main tool in the laboratory of Dr. Roger Nicoll at UCSF. She then became the electrophysiologist of Dr. Lisa Gunaydin's laboratory, also at UCSF, where she contributed to a better understanding of the brain circuits underlying anxiety-related behaviors. Argentina joined the MAC in 2020 to put all those years of basic research to good use outside the bench, but not far from the science.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Presence of Preoperative Neurodegeneration Biofluid Markers in Patients with Postoperative Delirium. Anesthesiology. 2023 10 01; 139(4):432-443. Leung JM, Rojas JC, Tang C, Chan B, Lario-Lago A, Boxer AL, Do Q, Kramer JH, Du Z, Du P, Sands LP, Perioperative Medicine Research Group. PMID: 37364279; PMCID: PMC10529495.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Plasma phosphorylated tau-217 exhibits sex-specific prognostication of cognitive decline and brain atrophy in cognitively unimpaired adults. Alzheimers Dement. 2024 Jan; 20(1):376-387. Saloner R, VandeVrede L, Asken BM, Paolillo EW, Gontrum EQ, Wolf A, Lario-Lago A, Milà-Alomà M, Triana-Baltzer G, Kolb HC, Dubal DB, Rabinovici GD, Miller BL, Boxer AL, Casaletto KB, Kramer JH. PMID: 37639492; PMCID: PMC10843677.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum. Ann Neurol. 2023 10; 94(4):632-646. Zhang L, Flagan TM, Häkkinen S, Chu SA, Brown JA, Lee AJ, Pasquini L, Mandelli ML, Gorno-Tempini ML, Sturm VE, Yokoyama JS, Appleby BS, Cobigo Y, Dickerson BC, Domoto-Reilly K, Geschwind DH, Ghoshal N, Graff-Radford NR, Grossman M, Hsiung GR, Huey ED, Kantarci K, Lario Lago A, Litvan I, Mackenzie IR, Mendez MF, Onyike CU, Ramos EM, Roberson ED, Tartaglia MC, Toga AW, Weintraub S, Wszolek ZK, Forsberg LK, Heuer HW, Boeve BF, Boxer AL, Rosen HJ, Miller BL, Seeley WW, Lee SE, ARTFL/LEFFTDS/ALLFTD Consortia. PMID: 37431188; PMCID: PMC10727479.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Alzheimer's pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome. Alzheimers Res Ther. 2023 07 21; 15(1):126. Asken BM, Tanner JA, Gaynor LS, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, Fonseca C, Shankar R, Grant H, Smith K, Lago AL, Xu H, La Joie R, Cobigo Y, Rosen H, Perry DC, Rojas JC, Miller BL, Gardner RC, Wang KKW, Kramer JH, Rabinovici GD. PMID: 37480088; PMCID: PMC10360257.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Gamma neuromodulation improves episodic memory and its associated network in amnestic mild cognitive impairment: a pilot study. Neurobiol Aging. 2023 09; 129:72-88. Jones KT, Gallen CL, Ostrand AE, Rojas JC, Wais P, Rini J, Chan B, Lago AL, Boxer A, Zhao M, Gazzaley A, Zanto TP. PMID: 37276822; PMCID: PMC10583532.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Sex-specific effects of SNAP-25 genotype on verbal memory and Alzheimer's disease biomarkers in clinically normal older adults. Alzheimers Dement. 2023 08; 19(8):3448-3457. Saloner R, Paolillo EW, Wojta KJ, Fonseca C, Gontrum EQ, Lario-Lago A, Rabinovici GD, Yokoyama JS, Rexach JE, Kramer JH, Casaletto KB. PMID: 36807763; PMCID: PMC10435666.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. CSF tau microtubule-binding region identifies pathological changes in primary tauopathies. Nat Med. 2022 12; 28(12):2547-2554. Horie K, Barthélemy NR, Spina S, VandeVrede L, He Y, Paterson RW, Wright BA, Day GS, Davis AA, Karch CM, Seeley WW, Perrin RJ, Koppisetti RK, Shaikh F, Lago AL, Heuer HW, Ghoshal N, Gabelle A, Miller BL, Boxer AL, Bateman RJ, Sato C. PMID: 36424467; PMCID: PMC9800273.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    8. Temporal order of clinical and biomarker changes in familial frontotemporal dementia. Nat Med. 2022 10; 28(10):2194-2206. Staffaroni AM, Quintana M, Wendelberger B, Heuer HW, Russell LL, Cobigo Y, Wolf A, Goh SM, Petrucelli L, Gendron TF, Heller C, Clark AL, Taylor JC, Wise A, Ong E, Forsberg L, Brushaber D, Rojas JC, VandeVrede L, Ljubenkov P, Kramer J, Casaletto KB, Appleby B, Bordelon Y, Botha H, Dickerson BC, Domoto-Reilly K, Fields JA, Foroud T, Gavrilova R, Geschwind D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grossman M, Hall MGH, Hsiung GY, Huey ED, Irwin D, Jones DT, Kantarci K, Kaufer D, Knopman D, Kremers W, Lago AL, Lapid MI, Litvan I, Lucente D, Mackenzie IR, Mendez MF, Mester C, Miller BL, Onyike CU, Rademakers R, Ramanan VK, Ramos EM, Rao M, Rascovsky K, Rankin KP, Roberson ED, Savica R, Tartaglia MC, Weintraub S, Wong B, Cash DM, Bouzigues A, Swift IJ, Peakman G, Bocchetta M, Todd EG, Convery RS, Rowe JB, Borroni B, Galimberti D, Tiraboschi P, Masellis M, Finger E, van Swieten JC, Seelaar H, Jiskoot LC, Sorbi S, Butler CR, Graff C, Gerhard A, Langheinrich T, Laforce R, Sanchez-Valle R, de Mendonça A, Moreno F, Synofzik M, Vandenberghe R, Ducharme S, Le Ber I, Levin J, Danek A, Otto M, Pasquier F, Santana I, Kornak J, Boeve BF, Rosen HJ, Rohrer JD, Boxer AL, Frontotemporal Dementia Prevention Initiative (FPI) Investigators. PMID: 36138153; PMCID: PMC9951811.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    9. Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology. Alzheimers Dement (Amst). 2022; 14(1):e12321. Berry K, Asken BM, Grab JD, Chan B, Lario Lago A, Wong R, Seetharaman S, LaHue SC, Possin KL, Rojas JC, Kramer JH, Boxer AL, Lai JC, VandeVrede L. PMID: 35845260; PMCID: PMC9274803.
      View in: PubMed   Mentions: 10  
    10. Plasma neurofilament light chain levels suggest neuroaxonal stability following therapeutic remyelination in people with multiple sclerosis. J Neurol Neurosurg Psychiatry. 2022 Jun 16. Abdelhak A, Cordano C, Boscardin WJ, Caverzasi E, Kuhle J, Chan B, Gelfand JM, Yiu HH, Oertel FC, Beaudry-Richard A, Condor Montes S, Oksenberg JR, Lario Lago A, Boxer A, Rojas-Martinez JC, Elahi FM, Chan JR, Green AJ. PMID: 35710320; PMCID: PMC9984688.
      View in: PubMed   Mentions: 3     Fields:    
    11. Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice. Nat Commun. 2021 10 15; 12(1):6040. Davis GL, Minerva AR, Lario A, Simmler LD, Rodriguez CI, Gunaydin LA. PMID: 34654803; PMCID: PMC8519915.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. Lancet Neurol. 2021 09; 20(9):739-752. Thijssen EH, La Joie R, Strom A, Fonseca C, Iaccarino L, Wolf A, Spina S, Allen IE, Cobigo Y, Heuer H, VandeVrede L, Proctor NK, Lago AL, Baker S, Sivasankaran R, Kieloch A, Kinhikar A, Yu L, Valentin MA, Jeromin A, Zetterberg H, Hansson O, Mattsson-Carlgren N, Graham D, Blennow K, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Teunissen CE, Rabinovici GD, Rojas JC, Dage JL, Boxer AL, Advancing Research and Treatment for Frontotemporal Lobar Degeneration investigators. PMID: 34418401; PMCID: PMC8711249.
      View in: PubMed   Mentions: 127     Fields:    
    13. A kinesin 1-protrudin complex mediates AMPA receptor synaptic removal during long-term depression. Cell Rep. 2021 08 03; 36(5):109499. Brachet A, Lario A, Fernández-Rodrigo A, Heisler FF, Gutiérrez Y, Lobo C, Kneussel M, Esteban JA. PMID: 34348158.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. KIF13A drives AMPA receptor synaptic delivery for long-term potentiation via endosomal remodeling. J Cell Biol. 2021 06 07; 220(6). Gutiérrez Y, López-García S, Lario A, Gutiérrez-Eisman S, Delevoye C, Esteban JA. PMID: 33999113; PMCID: PMC8129809.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. MAP1B Light Chain Modulates Synaptic Transmission via AMPA Receptor Intracellular Trapping. J Neurosci. 2017 10 11; 37(41):9945-9963. Palenzuela R, Gutiérrez Y, Draffin JE, Lario A, Benoist M, Esteban JA. PMID: 28904092; PMCID: PMC6596595.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    16. PTEN counteracts PIP3 upregulation in spines during NMDA-receptor-dependent long-term depression. J Cell Sci. 2014 Dec 15; 127(Pt 24):5253-60. Arendt KL, Benoist M, Lario A, Draffin JE, Muñoz M, Esteban JA. PMID: 25335889.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    17. PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. EMBO J. 2010 Aug 18; 29(16):2827-40. Jurado S, Benoist M, Lario A, Knafo S, Petrok CN, Esteban JA. PMID: 20628354; PMCID: PMC2924645.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
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