Gregory Ku, MD, PhD

Title(s)Associate Professor, Diabetes Center
SchoolSchool of Medicine
ORCID ORCID Icon0000-0001-5306-4225 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Harvard College, Cambridge, MAAB05/1996Biochemical Sciences
    University of California, San Francisco, San Francisco, CAM.D.2004 School of Medicine
    University of California, San Francisco, San Francisco, CAPh.D.2004 Graduate Division (Biomedical Sciences)
    University of California, San Francisco, San Francisco, CA Residency 7/2008Internal Medicine
    University of California, San Francisco, San Francisco, CAFellowship07/2014Endocrinology and Metabolism

    Collapse Overview 
    Collapse Overview
    My lab is interested in improving all forms of diabetes mellitus. We use functional genomics to find new gene targets to improve pancreatic beta cell survival, proliferation, and function.

    I also see diabetes patients in the UCSF Diabetes Clinic.

    Collapse Research 
    Collapse Research Activities and Funding
    The role of mitochondrial fission in beta cell function
    NIH R01DK118337Jan 22, 2020 - Dec 31, 2023
    Role: Principal Investigator
    Uncovering Two Novel Diabetes Drug Targets in the IDG
    NIH R03DK124904Sep 1, 2019 - Feb 28, 2021
    Role: Principal Investigator
    The role of Spry2 in beta cell function and the unfolded protein response
    NIH R01DK107650Dec 1, 2015 - Nov 30, 2021
    Role: Principal Investigator
    A novel, beta cell specific regulator of the insulin promoter
    NIH R03DK102892Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Discovering and dissecting new regulators of insulin production in beta cells
    NIH K08DK087945Aug 2, 2011 - Apr 30, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SARS-CoV-2 ORF3A interacts with the Clic-like chloride channel-1 (CLCC1) and triggers an unfolded protein response. PeerJ. 2023; 11:e15077. Gruner HN, Zhang Y, Shariati K, Yiv N, Hu Z, Wang Y, Hejtmancik JF, McManus MT, Tharp K, Ku G. PMID: 37033725; PMCID: PMC10078464.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    2. A Superfolder Green Fluorescent Protein-Based Biosensor Allows Monitoring of Chloride in the Endoplasmic Reticulum. ACS Sens. 2022 Aug 26; 7(8):2218-2224. Shariati K, Zhang Y, Giubbolini S, Parra R, Liang S, Edwards A, Hejtmancik JF, Ratto GM, Arosio D, Ku G. PMID: 35951356; PMCID: PMC9425558.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    3. CLCC1 c. 75C>A Mutation in Pakistani Derived Retinitis Pigmentosa Families Likely Originated With a Single Founder Mutation 2,000-5,000 Years Ago. Front Genet. 2022; 13:804924. Ma Y, Wang X, Shoshany N, Jiao X, Lee A, Ku G, Baple EL, Fasham J, Nadeem R, Naeem MA, Riazuddin S, Riazuddin SA, Crosby AH, Hejtmancik JF. PMID: 35391798; PMCID: PMC8980549.
      View in: PubMed   Mentions: 1  
    4. Adhesion-mediated mechanosignaling forces mitohormesis. Cell Metab. 2021 07 06; 33(7):1322-1341.e13. Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, Chen KH, Hoeve JT, Ku GM, Hellerstein M, Nomura DK, Saijo K, Gestwicki J, Dunn AR, Krogan NJ, Swaney DL, Dillin A, Weaver VM. PMID: 34019840; PMCID: PMC8266765.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    5. Selective monitoring of insulin secretion after CRISPR interference in intact pancreatic islets despite submaximal infection. Islets. 2020 05 03; 12(3):59-69. Shariati K, Pappalardo Z, Chopra DG, Yiv N, Sheen R, Ku G. PMID: 32579048; PMCID: PMC7527018.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. Sci Rep. 2020 03 27; 10(1):5629. Chopra DG, Yiv N, Hennings TG, Zhang Y, Ku GM. PMID: 32221326; PMCID: PMC7101378.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    7. In Vivo Deletion of β-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption. Endocrinology. 2018 09 01; 159(9):3245-3256. Hennings TG, Chopra DG, DeLeon ER, VanDeusen HR, Sesaki H, Merrins MJ, Ku GM. PMID: 30052866; PMCID: PMC6107751.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    8. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Endocrinology. 2018 09 01; 159(9):3321-3330. Lee J, Pappalardo Z, Chopra DG, Hennings TG, Vaughn I, Lan C, Choe JJ, Ang K, Chen S, Arkin M, McManus MT, German MS, Ku GM. PMID: 30059978; PMCID: PMC6112596.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output. Cell Stem Cell. 2018 03 01; 22(3):369-383.e8. Bulut-Karslioglu A, Macrae TA, Oses-Prieto JA, Covarrubias S, Percharde M, Ku G, Diaz A, McManus MT, Burlingame AL, Ramalho-Santos M. PMID: 29499153; PMCID: PMC5836508.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    10. A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. Diabetes. 2017 06; 66(6):1703-1712. Pappalardo Z, Gambhir Chopra D, Hennings TG, Richards H, Choe J, Yang K, Baeyens L, Ang K, Chen S, Arkin M, German MS, McManus MT, Ku GM. PMID: 28246293; PMCID: PMC5440024.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2888-93. Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS. PMID: 25695968; PMCID: PMC4352814.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    12. Menin determines K-RAS proliferative outputs in endocrine cells. J Clin Invest. 2014 Sep; 124(9):4093-101. Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS. PMID: 25133424; PMCID: PMC4153699.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    13. Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome. Mol Endocrinol. 2012 Oct; 26(10):1783-92. Ku GM, Kim H, Vaughn IW, Hangauer MJ, Myung Oh C, German MS, McManus MT. PMID: 22915829; PMCID: PMC3458219.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    14. An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet. 2012 Jan; 8(1):e1002449. Ku GM, Pappalardo Z, Luo CC, German MS, McManus MT. PMID: 22253604; PMCID: PMC3257298.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    15. Behind the scenes of a small RNA gene-silencing pathway. Hum Gene Ther. 2008 Jan; 19(1):17-26. Ku G, McManus MT. PMID: 18211225.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    16. A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J. 2001 Feb 01; 20(3):457-65. Ku GM, Yablonski D, Manser E, Lim L, Weiss A. PMID: 11157752; PMCID: PMC133476.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    17. A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation. J Biol Chem. 2000 Jan 21; 275(3):2185-90. Kuhne MR, Ku G, Weiss A. PMID: 10636924.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
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