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Gregory Ku, MD, PhD

Title(s)Assistant Professor, Diabetes Center
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Residency School of Medicine
    University of California, San FranciscoM.D.2004 School of Medicine
    University of California, San FranciscoPh.D.2004 Graduate Division (Biomedical Sciences)

    Collapse Research 
    Collapse Research Activities and Funding
    The role of mitochondrial fission in beta cell function
    NIH/NIDDK R01DK118337Jan 22, 2020 - Dec 31, 2023
    Role: Principal Investigator
    Uncovering Two Novel Diabetes Drug Targets in the IDG
    NIH/NIDDK R03DK124904Sep 1, 2019 - Aug 31, 2020
    Role: Principal Investigator
    The role of Spry2 in beta cell function and the unfolded protein response
    NIH/NIDDK R01DK107650Dec 1, 2015 - Nov 30, 2020
    Role: Principal Investigator
    A novel, beta cell specific regulator of the insulin promoter
    NIH/NIDDK R03DK102892Jul 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Discovering and dissecting new regulators of insulin production in beta cells
    NIH/NIDDK K08DK087945Aug 2, 2011 - Apr 30, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Chopra DG, Yiv N, Hennings TG, Zhang Y, Ku GM. Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. Sci Rep. 2020 Mar 27; 10(1):5629. PMID: 32221326.
      View in: PubMed
    2. Hennings TG, Chopra DG, DeLeon ER, VanDeusen HR, Sesaki H, Merrins MJ, Ku GM. In Vivo Deletion of ß-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption. Endocrinology. 2018 09 01; 159(9):3245-3256. PMID: 30052866.
      View in: PubMed
    3. Lee J, Pappalardo Z, Chopra DG, Hennings TG, Vaughn I, Lan C, Choe JJ, Ang K, Chen S, Arkin M, McManus MT, German MS, Ku GM. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Endocrinology. 2018 09 01; 159(9):3321-3330. PMID: 30059978.
      View in: PubMed
    4. Bulut-Karslioglu A, Macrae TA, Oses-Prieto JA, Covarrubias S, Percharde M, Ku G, Diaz A, McManus MT, Burlingame AL, Ramalho-Santos M. The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output. Cell Stem Cell. 2018 03 01; 22(3):369-383.e8. PMID: 29499153.
      View in: PubMed
    5. Pappalardo Z, Gambhir Chopra D, Hennings TG, Richards H, Choe J, Yang K, Baeyens L, Ang K, Chen S, Arkin M, German MS, McManus MT, Ku GM. A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. Diabetes. 2017 06; 66(6):1703-1712. PMID: 28246293.
      View in: PubMed
    6. Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS. Gai/o-coupled receptor signaling restricts pancreatic ß-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2888-93. PMID: 25695968.
      View in: PubMed
    7. Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS. Menin determines K-RAS proliferative outputs in endocrine cells. J Clin Invest. 2014 Sep; 124(9):4093-101. PMID: 25133424.
      View in: PubMed
    8. Ku GM, Kim H, Vaughn IW, Hangauer MJ, Myung Oh C, German MS, McManus MT. Research resource: RNA-Seq reveals unique features of the pancreatic ß-cell transcriptome. Mol Endocrinol. 2012 Oct; 26(10):1783-92. PMID: 22915829.
      View in: PubMed
    9. Ku GM, Pappalardo Z, Luo CC, German MS, McManus MT. An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet. 2012 Jan; 8(1):e1002449. PMID: 22253604.
      View in: PubMed
    10. Ku G, McManus MT. Behind the scenes of a small RNA gene-silencing pathway. Hum Gene Ther. 2008 Jan; 19(1):17-26. PMID: 18211225.
      View in: PubMed
    11. Ku GM, Yablonski D, Manser E, Lim L, Weiss A. A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. EMBO J. 2001 Feb 01; 20(3):457-65. PMID: 11157752.
      View in: PubMed
    12. Kuhne MR, Ku G, Weiss A. A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation. J Biol Chem. 2000 Jan 21; 275(3):2185-90. PMID: 10636924.
      View in: PubMed