Laurence Tecott

Title(s)Professor, Psychiatry
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco Residency School of Medicine
    University of California, San FranciscoM.D.1983School of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Striatal Circuits In The Serotonergic Modulation Of Hedonic States
    NIH/NIMH R01MH104671Sep 10, 2015 - Jun 30, 2017
    Role: Principal Investigator
    Impact of Energy Status on the Serotonergic Regulation of Energy Balance
    NIH/NIDDK R01DK085472Aug 15, 2010 - Jun 30, 2014
    Role: Principal Investigator
    A Quantitative Approach for Detecting Anxiolytic Drug Effects in the Mouse
    NIH/NIMH R21MH079145Aug 17, 2007 - Jul 31, 2009
    Role: Principal Investigator
    Serotonergic genetic influences on the impact of maternal environment
    NIH/NICHD R21HD051591Mar 15, 2007 - Feb 28, 2009
    Role: Principal Investigator
    Management and Analysis of Mouse Behavioral Datasets
    NIH/NIMH R01MH077128Jan 24, 2007 - Dec 31, 2009
    Role: Principal Investigator
    NIH/NIMH K02MH001949Sep 1, 2000 - Feb 28, 2006
    Role: Principal Investigator
    NIH/NIMH R01MH061624Jun 1, 2000 - May 31, 2006
    Role: Principal Investigator
    NIH/NIDA R01DA011177Aug 1, 1998 - Jun 30, 2002
    Role: Principal Investigator
    NIH/NIDA K21DA000282Jul 15, 1995 - Jun 30, 2000
    Role: Principal Investigator
    NIH/NIMH F32MH009099Oct 1, 1984
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Bonasera SJ, Arikkath J, Boska MD, Chaudoin TR, DeKorver NW, Goulding EH, Hoke TA, Mojtahedzedah V, Reyelts CD, Sajja B, Schenk AK, Tecott LH, Volden TA. Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits. Aging (Albany NY). 2016 09 20; 8(9):2153-2181. PMID: 27689748.
      View in: PubMed
    2. Bonasera SJ, Schenk AK, Luxenberg EJ, Wang X, Basbaum A, Tecott LH. Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli. PLoS One. 2015; 10(12):e0142906. PMID: 26630489; PMCID: PMC4667991.
    3. Urban DJ, Zhu H, Marcinkiewcz CA, Michaelides M, Oshibuchi H, Rhea D, Aryal DK, Farrell MS, Lowery-Gionta E, Olsen RH, Wetsel WC, Kash TL, Hurd YL, Tecott LH, Roth BL. Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons. Neuropsychopharmacology. 2016 Apr; 41(5):1404-15. PMID: 26383016; PMCID: PMC4793125 [Available on 04/01/17].
    4. Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS. Gai/o-coupled receptor signaling restricts pancreatic ß-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 03; 112(9):2888-93. PMID: 25695968; PMCID: PMC4352814.
    5. Tong CK, Chen J, Cebrián-Silla A, Mirzadeh Z, Obernier K, Guinto CD, Tecott LH, García-Verdugo JM, Kriegstein A, Alvarez-Buylla A. Axonal control of the adult neural stem cell niche. Cell Stem Cell. 2014 Apr 03; 14(4):500-11. PMID: 24561083; PMCID: PMC4080817.
    6. Donovan MH, Tecott LH. Serotonin and the regulation of mammalian energy balance. Front Neurosci. 2013; 7:36. PMID: 23543912; PMCID: PMC3608917.
    7. Pennanen L, van der Hart M, Yu L, Tecott LH. Impact of serotonin (5-HT)2C receptors on executive control processes. Neuropsychopharmacology. 2013 May; 38(6):957-67. PMID: 23303047; PMCID: PMC3629384.
    8. Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS. Convergence of the insulin and serotonin programs in the pancreatic ß-cell. Diabetes. 2011 Dec; 60(12):3208-16. PMID: 22013016; PMCID: PMC3219954.
    9. Xiong H, Goulding EH, Carlson EJ, Tecott LH, McCulloch CE, Sen S. A flexible estimating equations approach for mapping function-valued traits. Genetics. 2011 Sep; 189(1):305-16. PMID: 21705752; PMCID: PMC3176135.
    10. Urban R, Scherrer G, Goulding EH, Tecott LH, Basbaum AI. Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity. Pain. 2011 May; 152(5):990-1000. PMID: 21256675; PMCID: PMC3079194.
    11. Honig G, Liou A, Berger M, German MS, Tecott LH. Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line. J Biomed Sci. 2010 Oct 17; 17:82. PMID: 20950489; PMCID: PMC2966455.
    12. Oury F, Yadav VK, Wang Y, Zhou B, Liu XS, Guo XE, Tecott LH, Schutz G, Means AR, Karsenty G. CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons. Genes Dev. 2010 Oct 15; 24(20):2330-42. PMID: 20952540; PMCID: PMC2956211.
    13. Hsu JL, Yu L, Sullivan E, Bowman M, Mistlberger RE, Tecott LH. Enhanced food anticipatory activity associated with enhanced activation of extrahypothalamic neural pathways in serotonin2C receptor null mutant mice. PLoS One. 2010 Jul 27; 5(7):e11802. PMID: 20668550; PMCID: PMC2910710.
    14. Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German MS. Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med. 2010 Jul; 16(7):804-8. PMID: 20581837; PMCID: PMC2921604.
    15. Mikulski Z, Zaslona Z, Cakarova L, Hartmann P, Wilhelm J, Tecott LH, Lohmeyer J, Kummer W. Serotonin activates murine alveolar macrophages through 5-HT2C receptors. Am J Physiol Lung Cell Mol Physiol. 2010 Aug; 299(2):L272-80. PMID: 20495077.
      View in: PubMed
    16. Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G. A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell. 2009 Sep 04; 138(5):976-89. PMID: 19737523; PMCID: PMC2768582.
    17. Honig G, Jongsma ME, van der Hart MC, Tecott LH. Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain. PLoS One. 2009 Aug 27; 4(8):e6797. PMID: 19710918; PMCID: PMC2728775.
    18. Mao R, Page DT, Merzlyak I, Kim C, Tecott LH, Janak PH, Rubenstein JL, Sur M. Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons. J Neurodev Disord. 2009 Sep; 1(3):224-36. PMID: 19816534.
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    19. Abdallah L, Bonasera SJ, Hopf FW, O'Dell L, Giorgetti M, Jongsma M, Carra S, Pierucci M, Di Giovanni G, Esposito E, Parsons LH, Bonci A, Tecott LH. Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. J Neurosci. 2009 Jun 24; 29(25):8156-65. PMID: 19553455; PMCID: PMC3077993.
    20. Goulding EH, Schenk AK, Juneja P, MacKay AW, Wade JM, Tecott LH. A robust automated system elucidates mouse home cage behavioral structure. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20575-82. PMID: 19106295.
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    21. Fyffe SL, Neul JL, Samaco RC, Chao HT, Ben-Shachar S, Moretti P, McGill BE, Goulding EH, Sullivan E, Tecott LH, Zoghbi HY. Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress. Neuron. 2008 Sep 25; 59(6):947-58. PMID: 18817733.
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    22. Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biol Psychiatry. 2008 Apr 15; 63(8):725-7. PMID: 18371494.
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    23. Casper RC, Sullivan EL, Tecott L. Relevance of animal models to human eating disorders and obesity. Psychopharmacology (Berl). 2008 Aug; 199(3):313-29. PMID: 18317734.
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    24. Scott-McKean JJ, Wenger GR, Tecott LH, Costa AC. 5-HT(1A) Receptor Null Mutant Mice Responding Under a Differential-Reinforcement-of-Low-Rate 72-Second Schedule of Reinforcement. Open Neuropsychopharmacol J. 2008 Jan 01; 1:24-32. PMID: 20352018.
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    25. Bonasera SJ, Schenk AK, Luxenberg EJ, Tecott LH. A novel method for automatic quantification of psychostimulant-evoked route-tracing stereotypy: application to Mus musculus. Psychopharmacology (Berl). 2008 Mar; 196(4):591-602. PMID: 18097652; PMCID: PMC2562621.
    26. Wade JM, Juneja P, MacKay AW, Graham J, Havel PJ, Tecott LH, Goulding EH. Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors. Endocrinology. 2008 Mar; 149(3):955-61. PMID: 18039786; PMCID: PMC2275362.
    27. Tecott LH. Serotonin and the orchestration of energy balance. Cell Metab. 2007 Nov; 6(5):352-61. PMID: 17983581.
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    28. Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, Yeo GS, O'Rahilly S, Colmers WF, Elmquist JK, Tecott LH. Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J Neurosci. 2007 Jun 27; 27(26):6956-64. PMID: 17596444.
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    29. Zhang J, Pho V, Bonasera SJ, Holtzman J, Tang AT, Hellmuth J, Tang S, Janak PH, Tecott LH, Huang EJ. Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci. 2007 Jan; 10(1):77-86. PMID: 17159989; PMCID: PMC3578579.
    30. O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. J Clin Invest. 2006 Apr; 116(4):1005-15. PMID: 16585965; PMCID: PMC1421341.
    31. Bonasera SJ, Chu HM, Brennan TJ, Tecott LH. A null mutation of the serotonin 6 receptor alters acute responses to ethanol. Neuropsychopharmacology. 2006 Aug; 31(8):1801-13. PMID: 16452990.
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    32. Kushwaha N, Harwood SC, Wilson AM, Berger M, Tecott LH, Roth BL, Albert PR. Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling. Mol Pharmacol. 2006 May; 69(5):1518-26. PMID: 16410407.
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    33. Storm EE, Tecott LH. Social circuits: peptidergic regulation of mammalian social behavior. Neuron. 2005 Aug 18; 47(4):483-6. PMID: 16102531.
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    34. Cannon CM, Abdallah L, Tecott LH, During MJ, Palmiter RD. Dysregulation of striatal dopamine signaling by amphetamine inhibits feeding by hungry mice. Neuron. 2004 Oct 28; 44(3):509-20. PMID: 15504330.
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    35. Cremers TI, Giorgetti M, Bosker FJ, Hogg S, Arnt J, Mørk A, Honig G, Bøgesø KP, Westerink BH, den Boer H, Wikstrom HV, Tecott LH. Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade. Neuropsychopharmacology. 2004 Oct; 29(10):1782-9. PMID: 15138437.
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    36. Tecott LH, Nestler EJ. Neurobehavioral assessment in the information age. Nat Neurosci. 2004 May; 7(5):462-6. PMID: 15114359.
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    37. Giorgetti M, Tecott LH. Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems. Eur J Pharmacol. 2004 Mar 19; 488(1-3):1-9. PMID: 15044029.
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    38. Tecott LH, Abdallah L. Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice. CNS Spectr. 2003 Aug; 8(8):584-8. PMID: 12907921.
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    39. Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, Reichardt LF. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci. 2003 Jul; 6(7):736-42. PMID: 12796784.
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    40. Heisler LK, Cowley MA, Kishi T, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro J, Zigman JM, Cone RD, Elmquist JK. Central serotonin and melanocortin pathways regulating energy homeostasis. Ann N Y Acad Sci. 2003 Jun; 994:169-74. PMID: 12851313.
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    41. Tecott LH. The genes and brains of mice and men. Am J Psychiatry. 2003 Apr; 160(4):646-56. PMID: 12668350.
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    42. Nonogaki K, Abdallah L, Goulding EH, Bonasera SJ, Tecott LH. Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice. Diabetes. 2003 Feb; 52(2):315-20. PMID: 12540602.
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    43. Rocha BA, Goulding EH, O'Dell LE, Mead AN, Coufal NG, Parsons LH, Tecott LH. Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice. J Neurosci. 2002 Nov 15; 22(22):10039-45. PMID: 12427861.
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    44. Frank MG, Stryker MP, Tecott LH. Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor. Neuropsychopharmacology. 2002 Nov; 27(5):869-73. PMID: 12431861; PMCID: PMC2452994.
    45. Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H, Lee CE, Cone RD, Elmquist JK. Activation of central melanocortin pathways by fenfluramine. Science. 2002 Jul 26; 297(5581):609-11. PMID: 12142539.
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    46. Nonogaki K, Memon RA, Grunfeld C, Feingold KR, Tecott LH. Altered gene expressions involved in energy expenditure in 5-HT(2C) receptor mutant mice. Biochem Biophys Res Commun. 2002 Jul 12; 295(2):249-54. PMID: 12150939.
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    47. López-Giménez JF, Tecott LH, Palacios JM, Mengod G, Vilaró MT. Serotonin 5- HT (2C) receptor knockout mice: autoradiographic analysis of multiple serotonin receptors. J Neurosci Res. 2002 Jan 01; 67(1):69-85. PMID: 11754082.
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    48. Heisler LK, Tecott LH. Knockout Corner: Neurobehavioural consequences of a serotonin 5-HT(2C) receptor gene mutation. Int J Neuropsychopharmacol. 1999 Mar; 2(1):67-69. PMID: 11281972.
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