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Aaron Clark, MD, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentNeurological Surgery
Address400 Parnassus Avenue
San Francisco CA 94117
Phone415-353-3191
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    Collapse Research 
    Collapse Research Activities and Funding
    B7-H1 mediated immunosuppression in immunocompetent animal model of gliomas
    NIH/NCI F32CA174256Feb 26, 2013 - Feb 25, 2014
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Safaee MM, Zarkowsky D, Eichler CM, Pekmezci M, Clark A. Management of aortic injury during minimally invasive lateral lumbar interbody fusion. Eur Spine J. 2018 May 07. PMID: 29736802.
      View in: PubMed
    2. Safaee MM, Clark A, Burkhardt JK, Winkler EA, Lawton MT. Timing, severity of deficits, and clinical improvement after surgery for spinal dural arteriovenous fistulas. J Neurosurg Spine. 2018 Apr 20; 1-7. PMID: 29676670.
      View in: PubMed
    3. Dumont RA, Keen NN, Bloomer CW, Schwartz BS, Talbott J, Clark A, Wilson DM, Chin CT. Clinical Utility of Diffusion-Weighted Imaging in Spinal Infections. Clin Neuroradiol. 2018 Mar 26. PMID: 29582111.
      View in: PubMed
    4. Safaee MM, Ames CP, Deviren V, Clark A. Minimally Invasive Lateral Retroperitoneal Approach for Resection of Extraforaminal Lumbar Plexus Schwannomas: Operative Techniques and Literature Review. Oper Neurosurg (Hagerstown). 2018 Jan 17. PMID: 29351647.
      View in: PubMed
    5. Grabel ZJ, Hart RA, Clark A, Park SH, Shaffrey CI, Scheer JK, Smith JS, Kelly MP, DePasse JM, Gupta MC, Ames CP, Daniels AH. Adult Spinal Deformity Knowledge in Orthopedic Spine Surgeons: Impact of Fellowship Training, Experience, and Practice Characteristics. Spine Deform. 2018 Jan; 6(1):60-66. PMID: 29287819.
      View in: PubMed
    6. Safaee MM, Oh T, Pekmezci M, Clark A. Radiation exposure with hybrid image-guidance-based minimally invasive transforaminal lumbar interbody fusion. J Clin Neurosci. 2018 Feb; 48:122-127. PMID: 29137917.
      View in: PubMed
    7. Clark A, Safaee MM, Khan NR, Brown MT, Foley KT. Tubular microdiscectomy: techniques, complication avoidance, and review of the literature. Neurosurg Focus. 2017 Aug; 43(2):E7. PMID: 28760036.
      View in: PubMed
    8. Burkhardt JK, Safaee MM, Clark A, Lawton MT. Sacral epidural arteriovenous fistulas: imitators of spinal dural arteriovenous fistulas with different pathologic anatomy: report of three cases and review of the literature. Acta Neurochir (Wien). 2017 Jun; 159(6):1087-1092. PMID: 28405771.
      View in: PubMed
    9. Ames CP, Clark A, Kanter AS, Arnold PM, Fehlings MG, Mroz TE, Riew KD. Hypoglossal Nerve Palsy After Cervical Spine Surgery. Global Spine J. 2017 Apr; 7(1 Suppl):37S-39S. PMID: 28451489.
      View in: PubMed
    10. Clark A, Wang DD, Lawton MT. Spinal cavernous malformations. Handb Clin Neurol. 2017; 143:303-308. PMID: 28552154.
      View in: PubMed
    11. Lau D, Funao H, Clark A, Nicholls F, Smith J, Bess S, Shaffrey C, Schwab FJ, Lafage V, Deviren V, Hart R, Kebaish KM, Ames CP. The Clinical Correlation of the Hart-ISSG Proximal Junctional Kyphosis Severity Scale With Health-Related Quality-of-life Outcomes and Need for Revision Surgery. Spine (Phila Pa 1976). 2016 Feb; 41(3):213-23. PMID: 26641842.
      View in: PubMed
    12. Clark A, Fakurnejad S, Ma Q, Hashizume R. Bioluminescence Imaging of an Immunocompetent Animal Model for Glioblastoma. J Vis Exp. 2016 Jan 15; (107):e53287. PMID: 26863490; PMCID: PMC4781579.
    13. Khan NR, Clark A, Lee SL, Venable GT, Rossi NB, Foley KT. Surgical Outcomes for Minimally Invasive vs Open Transforaminal Lumbar Interbody Fusion: An Updated Systematic Review and Meta-analysis. Neurosurgery. 2015 Dec; 77(6):847-74; discussion 874. PMID: 26214320.
      View in: PubMed
    14. Clark A, Safaee M, Chou D, Weinstein PR, Molinaro AM, Clark JP, Mummaneni PV. Comparative Sensitivity of Intraoperative Motor Evoked Potential Monitoring in Predicting Postoperative Neurologic Deficits: Nondegenerative versus Degenerative Myelopathy. Global Spine J. 2016 Aug; 6(5):452-8. PMID: 27433429; PMCID: PMC4947397.
    15. Saigal R, Clark A, Scheer JK, Smith JS, Bess S, Mummaneni PV, McCarthy IM, Hart RA, Kebaish KM, Klineberg EO, Deviren V, Schwab F, Shaffrey CI, Ames CP. Adult Spinal Deformity Patients Recall Fewer Than 50% of the Risks Discussed in the Informed Consent Process Preoperatively and the Recall Rate Worsens Significantly in the Postoperative Period. Spine (Phila Pa 1976). 2015 Jul 15; 40(14):1079-85. PMID: 25946720.
      View in: PubMed
    16. Sun MZ, Oh T, Ivan ME, Clark A, Safaee M, Sayegh ET, Kaur G, Parsa AT, Bloch O. Survival impact of time to initiation of chemoradiotherapy after resection of newly diagnosed glioblastoma. J Neurosurg. 2015 May; 122(5):1144-50. PMID: 25768833.
      View in: PubMed
    17. Safaee M, Fakurnejad S, Bloch O, Clark A, Ivan ME, Sun MZ, Oh T, Phillips JJ, Parsa AT. Proportional upregulation of CD97 isoforms in glioblastoma and glioblastoma-derived brain tumor initiating cells. PLoS One. 2015; 10(2):e0111532. PMID: 25714433; PMCID: PMC4340952.
    18. Scheer JK, Smith JS, Clark A, Lafage V, Kim HJ, Rolston JD, Eastlack R, Hart RA, Protopsaltis TS, Kelly MP, Kebaish K, Gupta M, Klineberg E, Hostin R, Shaffrey CI, Schwab F, Ames CP. Comprehensive study of back and leg pain improvements after adult spinal deformity surgery: analysis of 421 patients with 2-year follow-up and of the impact of the surgery on treatment satisfaction. J Neurosurg Spine. 2015 May; 22(5):540-53. PMID: 25700238.
      View in: PubMed
    19. Osorio JA, Clark A, Safaee M, Tate MC, Aghi MK, Parsa A, McDermott MW. Intraoperative Conversion from Endoscopic to Open Transcortical-Transventricular Removal of Colloid Cysts as a Salvage Procedure. Cureus. 2015 Feb; 7(2):e247. PMID: 26180671; PMCID: PMC4494539.
    20. Clark A, Safaee M, Oh T, Ivan ME, Parimi V, Hashizume R, Ozawa T, James CD, Bloch O, Parsa AT. Stable luciferase expression does not alter immunologic or in vivo growth properties of GL261 murine glioma cells. J Transl Med. 2014 Dec 03; 12:345. PMID: 25464980; PMCID: PMC4258256.
    21. Lau D, Clark A, Scheer JK, Daubs MD, Coe JD, Paonessa KJ, LaGrone MO, Kasten MD, Amaral RA, Trobisch PD, Lee JH, Fabris-Monterumici D, Anand N, Cree AK, Hart RA, Hey LA, Ames CP. Proximal junctional kyphosis and failure after spinal deformity surgery: a systematic review of the literature as a background to classification development. Spine (Phila Pa 1976). 2014 Dec 01; 39(25):2093-102. PMID: 25271516.
      View in: PubMed
    22. Ivan ME, Safaee M, Oh T, Clark A, Sun MZ, Kim J, Bloch O, Jahangiri A, Phillips JJ, Aghi MK, Parsa AT. Epidermal growth factor-like module containing mucin-like hormone receptor 2 expression in gliomas. J Neurooncol. 2015 Jan; 121(1):53-61. PMID: 25200831.
      View in: PubMed
    23. Sun MZ, Ivan ME, Oh MC, Delance AR, Clark A, Safaee M, Oh T, Kaur G, Molinaro A, Gupta N, Parsa AT. Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014 Nov; 120(2):353-60. PMID: 25106865.
      View in: PubMed
    24. Clark A, Garcia RM, Keefe MK, Koski TR, Rosner MK, Smith JS, Cheng JS, Shaffrey CI, McCormick PC, Ames CP. Results of the AANS membership survey of adult spinal deformity knowledge: impact of training, practice experience, and assessment of potential areas for improved education: Clinical article. J Neurosurg Spine. 2014 Oct; 21(4):640-7. PMID: 25036219.
      View in: PubMed
    25. Sparrey CJ, Bailey JF, Safaee M, Clark A, Lafage V, Schwab F, Smith JS, Ames CP. Etiology of lumbar lordosis and its pathophysiology: a review of the evolution of lumbar lordosis, and the mechanics and biology of lumbar degeneration. Neurosurg Focus. 2014 May; 36(5):E1. PMID: 24785474.
      View in: PubMed
    26. Oh T, Fakurnejad S, Sayegh ET, Clark A, Ivan ME, Sun MZ, Safaee M, Bloch O, James CD, Parsa AT. Immunocompetent murine models for the study of glioblastoma immunotherapy. J Transl Med. 2014 Apr 29; 12:107. PMID: 24779345; PMCID: PMC4012243.
    27. Clark A, Tang JA, Leasure JM, Ivan ME, Kondrashov D, Buckley JM, Deviren V, Ames CP. Gait-simulating fatigue loading analysis and sagittal alignment failure of spinal pelvic reconstruction after total sacrectomy: comparison of 3 techniques. J Neurosurg Spine. 2014 Apr; 20(4):364-70. PMID: 24460580.
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    28. Oh T, Ivan ME, Sun MZ, Safaee M, Fakurnejad S, Clark A, Sayegh ET, Bloch O, Parsa AT. PI3K pathway inhibitors: potential prospects as adjuncts to vaccine immunotherapy for glioblastoma. Immunotherapy. 2014; 6(6):737-53. PMID: 25186604; PMCID: PMC4580256.
    29. Abla AA, Clark A, Lawton ML. Resection of pontine cavernous malformation through the pontomedullary sulcus. Neurosurg Focus. 2014 Jan; 36(1 Suppl):1. PMID: 24380516.
      View in: PubMed
    30. Sun MZ, Ivan ME, Clark A, Oh MC, Delance AR, Oh T, Safaee M, Kaur G, Bloch O, Molinaro A, Gupta N, Parsa AT. Gross total resection improves overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014 Jan; 116(1):179-85. PMID: 24166581.
      View in: PubMed
    31. Feldman WB, Clark A, Safaee M, Ames CP, Parsa AT. Tumor control after surgery for spinal myxopapillary ependymomas: distinct outcomes in adults versus children: a systematic review. J Neurosurg Spine. 2013 Oct; 19(4):471-6. PMID: 23971762.
      View in: PubMed
    32. Safaee M, Clark A, Ivan ME, Oh MC, Bloch O, Sun MZ, Oh T, Parsa AT. CD97 is a multifunctional leukocyte receptor with distinct roles in human cancers (Review). Int J Oncol. 2013 Nov; 43(5):1343-50. PMID: 23969601.
      View in: PubMed
    33. Jahangiri A, Clark A, Han SJ, Kunwar S, Blevins LS, Aghi MK. Socioeconomic factors associated with pituitary apoplexy. J Neurosurg. 2013 Dec; 119(6):1432-6. PMID: 23889139.
      View in: PubMed
    34. Sun MZ, Kim JM, Oh MC, Safaee M, Kaur G, Clark A, Bloch O, Ivan ME, Kaur R, Oh T, Fouse SD, Phillips JJ, Berger MS, Parsa AT. Na?/K?-ATPase ß2-subunit (AMOG) expression abrogates invasion of glioblastoma-derived brain tumor-initiating cells. Neuro Oncol. 2013 Nov; 15(11):1518-31. PMID: 23887941; PMCID: PMC3813412.
    35. Clark A, Ziewacz JE, Safaee M, Lau D, Lyon R, Chou D, Weinstein PR, Ames CP, Clark JP, Mummaneni PV. Intraoperative neuromonitoring with MEPs and prediction of postoperative neurological deficits in patients undergoing surgery for cervical and cervicothoracic myelopathy. Neurosurg Focus. 2013 Jul; 35(1):E7. PMID: 23815252.
      View in: PubMed
    36. DeLance AR, Safaee M, Oh MC, Clark A, Kaur G, Sun MZ, Bollen AW, Phillips JJ, Parsa AT. Tuberculoma of the central nervous system. J Clin Neurosci. 2013 Oct; 20(10):1333-41. PMID: 23768968.
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    37. Safaee M, Clark A, Tihan T, Parsa AT, Bloch O. Falcine and parasagittal chondrosarcomas. J Clin Neurosci. 2013 Sep; 20(9):1232-6. PMID: 23759737.
      View in: PubMed
    38. Safaee M, Clark A, Oh MC, Ivan ME, Bloch O, Kaur G, Sun MZ, Kim JM, Oh T, Berger MS, Parsa AT. Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients. PLoS One. 2013; 8(4):e62765. PMID: 23658650; PMCID: PMC3637305.
    39. Clark A, Jahangiri A, Garcia RM, George JR, Sughrue ME, McDermott MW, El-Sayed IH, Aghi MK. Endoscopic surgery for tuberculum sellae meningiomas: a systematic review and meta-analysis. Neurosurg Rev. 2013 Jul; 36(3):349-59. PMID: 23568697.
      View in: PubMed
    40. Cage TA, Clark A, Aranda D, Gupta N, Sun PP, Parsa AT, Auguste KI. A systematic review of treatment outcomes in pediatric patients with intracranial ependymomas. J Neurosurg Pediatr. 2013 Jun; 11(6):673-81. PMID: 23540528.
      View in: PubMed
    41. Safaee M, Clark A, Bloch O, Oh MC, Singh A, Auguste KI, Gupta N, McDermott MW, Aghi MK, Berger MS, Parsa AT. Surgical outcomes in choroid plexus papillomas: an institutional experience. J Neurooncol. 2013 May; 113(1):117-25. PMID: 23468001.
      View in: PubMed
    42. Clark A, Cage TA, Aranda D, Parsa AT, Sun PP, Auguste KI, Gupta N. A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma. Childs Nerv Syst. 2013 Feb; 29(2):231-8. PMID: 23089933.
      View in: PubMed
    43. Clark A, Cage TA, Aranda D, Parsa AT, Auguste KI, Gupta N. Treatment-related morbidity and the management of pediatric craniopharyngioma: a systematic review. J Neurosurg Pediatr. 2012 Oct; 10(4):293-301. PMID: 22920295.
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    44. Clark A, Kuperman RA, Auguste KI, Sun PP. Intractable episodic bradycardia resulting from progressive lead traction in an epileptic child with a vagus nerve stimulator: a delayed complication. J Neurosurg Pediatr. 2012 Apr; 9(4):389-93. PMID: 22462703.
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    45. Clark A, Lamborn KR, Butowski NA, Chang SM, Prados MD, Clarke JL, McDermott MW, Parsa AT, Berger MS, Aghi MK. Neurosurgical management and prognosis of patients with glioblastoma that progresses during bevacizumab treatment. Neurosurgery. 2012 Feb; 70(2):361-70. PMID: 21841523.
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    46. Clark A, Auguste KI, Sun PP. Cervical spinal stenosis and sports-related cervical cord neurapraxia. Neurosurg Focus. 2011 Nov; 31(5):E7. PMID: 22044106.
      View in: PubMed
    47. Han SJ, Clark A, Ivan ME, Parsa AT, Perry A. Pathology of pineal parenchymal tumors. Neurosurg Clin N Am. 2011 Jul; 22(3):335-40, vii. PMID: 21801981.
      View in: PubMed
    48. Clark A, Sughrue ME, Aranda D, Parsa AT. Contemporary management of pineocytoma. Neurosurg Clin N Am. 2011 Jul; 22(3):403-7, ix. PMID: 21801989.
      View in: PubMed
    49. Clark A, Butowski NA, Chang SM, Prados MD, Clarke J, Polley MY, Sughrue ME, McDermott MW, Parsa AT, Berger MS, Aghi MK. Impact of bevacizumab chemotherapy on craniotomy wound healing. J Neurosurg. 2011 Jun; 114(6):1609-16. PMID: 21142749.
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    50. Ivan ME, Sughrue ME, Clark A, Kane AJ, Aranda D, Barani IJ, Parsa AT. A meta-analysis of tumor control rates and treatment-related morbidity for patients with glomus jugulare tumors. J Neurosurg. 2011 May; 114(5):1299-305. PMID: 21029039.
      View in: PubMed
    51. Chen MY, Clark A, Chan DC, Ware JL, Holt SE, Chidambaram A, Fillmore HL, Broaddus WC. Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression. J Neurooncol. 2011 May; 103(1):87-102. PMID: 20820871; PMCID: PMC3277601.
    52. Clark A, Ivan ME, Sughrue ME, Yang I, Aranda D, Han SJ, Kane AJ, Parsa AT. Tumor control after surgery and radiotherapy for pineocytoma. J Neurosurg. 2010 Aug; 113(2):319-24. PMID: 20136388.
      View in: PubMed
    53. Clark A, Lu DC, Richardson RM, Tihan T, Parsa AT, Chou D, Barbaro NM, Kunwar S, Weinstein PR, Lawton MT, Berger MS, McDermott MW. Surgical technique of temporary arterial occlusion in the operative management of spinal hemangioblastomas. World Neurosurg. 2010 Jul; 74(1):200-5. PMID: 21300014.
      View in: PubMed
    54. Sughrue ME, Yang I, Kane AJ, Fang S, Clark A, Aranda D, Barani IJ, Parsa AT. Endocrinologic, neurologic, and visual morbidity after treatment for craniopharyngioma. J Neurooncol. 2011 Feb; 101(3):463-76. PMID: 20535527; PMCID: PMC3024496.
    55. Clark A, Sughrue ME, Ivan ME, Aranda D, Rutkowski MJ, Kane AJ, Chang S, Parsa AT. Factors influencing overall survival rates for patients with pineocytoma. J Neurooncol. 2010 Nov; 100(2):255-60. PMID: 20461445; PMCID: PMC2995321.
    56. Clark A, Ware JL, Chen MY, Graf MR, Van Meter TE, Dos Santos WG, Fillmore HL, Broaddus WC. Effect of WT1 gene silencing on the tumorigenicity of human glioblastoma multiforme cells. J Neurosurg. 2010 Jan; 112(1):18-25. PMID: 19392599.
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    57. Clark A, Lee K, Broaddus WC, Martin MJ, Ghatak NR, Grossman CE, Baker S, Baykal A. Primary brain T-cell lymphoma of the lymphoblastic type presenting as altered mental status. Acta Neurochir (Wien). 2010 Jan; 152(1):163-8. PMID: 19578806; PMCID: PMC2801848.
    58. Clark A, Dos Santos WG, McCready J, Chen MY, Van Meter TE, Ware JL, Wolber SB, Fillmore H, Broaddus WC. Wilms tumor 1 expression in malignant gliomas and correlation of +KTS isoforms with p53 status. J Neurosurg. 2007 Sep; 107(3):586-92. PMID: 17886559.
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    59. Clark A, Chan DC, Chen MY, Fillmore H, Dos Santos WG, Van Meter TE, Graf MR, Broaddus WC. Down-regulation of Wilms' tumor 1 expression in glioblastoma cells increases radiosensitivity independently of p53. J Neurooncol. 2007 Jun; 83(2):163-72. PMID: 17206472.
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