Robert Nissenson, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address4150 Clement St
San Francisco CA 94121
Phone415-750-2089
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    Collapse Biography 
    Collapse Education and Training
    Cornell University, Ithaca, NY06/1969Chemistry
    Northwestern University, Evanston, ILB.A.06/1971Biology
    Northwestern University Medical School, Chicago, ILPh.D.06/1976Physiology
    Mayo Clinic, Rochester, MN06/1977Postdoctoral Research in Endocrinology
    University of California, San Francisco, San Francisco, CA06/1980Postdoctoral Research in Endocrinology

    Collapse Research 
    Collapse Research Activities and Funding
    Inhibitory G protein (Gi) signaling in bone disease and repair
    NIH I01BX003212Oct 1, 2016 - Mar 31, 2021
    Role: Principal Investigator
    Mechanisms Underlying Hormonal Regulation of Fracture Repair
    NIH IP1BX001599Jan 1, 2012 - Dec 31, 2015
    Role: Co-Principal Investigator
    G Protein Signaling in Osteoblasts
    NIH I01BX001496Oct 1, 2011 - Sep 30, 2015
    Role: Principal Investigator
    G PROTEIN SIGNALING IN OSTEOBLASTS
    NIH R01DK072071Feb 1, 2006 - Dec 31, 2011
    Role: Principal Investigator
    G Protein Signaling in Osteoblasts
    NIH R56DK072071Apr 12, 2005 - Sep 30, 2011
    Role: Principal Investigator
    Role of Beta-Catenin Signaling in Osteoblast Function
    NIH R21AR051692Sep 30, 2004 - Jun 30, 2006
    Role: Principal Investigator
    2003 Bones &Teeth Gordon Conference
    NIH R13AR050390Aug 1, 2003 - Jul 31, 2004
    Role: Principal Investigator
    CLONING OF THE PARATHYROID HORMONE RECEPTOR CDNA
    NIH R01DK042146May 1, 1991 - Apr 30, 1995
    Role: Principal Investigator
    PARATHYROID HORMONE RECEPTORS IN KIDNEY AND BONE
    NIH R01DK035323Apr 1, 1985 - Dec 31, 2004
    Role: Principal Investigator
    PARATHYROID HORMONE RECEPTORS IN KIDNEY AND BONE
    NIH R01AM035323Apr 1, 1985 - Mar 31, 1988
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Academic Senate

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Female-Specific Role of Progranulin to Suppress Bone Formation. Endocrinology. 2019 09 01; 160(9):2024-2037. Wang L, Roth T, Nakamura MC, Nissenson RA. PMID: 31237618.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    2. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nat Commun. 2019 01 11; 10(1):163. Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA. PMID: 30635563.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    3. Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice. Endocrinology. 2017 09 01; 158(9):2741-2753. Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson RA. PMID: 28911171.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    4. Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice. Endocrinology. 2017 06 01; 158(6):1715-1726. Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA. PMID: 28407060.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    5. Osteoblast-derived FGF9 regulates skeletal homeostasis. Bone. 2017 05; 98:18-25. Wang L, Roth T, Abbott M, Ho L, Wattanachanya L, Nissenson RA. PMID: 28189801.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    6. Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury. Muscles Ligaments Tendons J. 2016 Jan-Mar; 6(1):6-15. Liu X, Ning AY, Chang NC, Kim H, Nissenson R, Wang L, Feeley BT. PMID: 27331027.
      View in: PubMed   Mentions:
    7. Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice. J Nutr Biochem. 2016 08; 34:73-82. Shahnazari M, Turner RT, Iwaniec UT, Wronski TJ, Li M, Ferruzzi MG, Nissenson RA, Halloran BP. PMID: 27239754.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. Negative Skeletal Effects of Locally Produced Adiponectin. PLoS One. 2015; 10(7):e0134290. Abbott MJ, Roth TM, Ho L, Wang L, O'Carroll D, Nissenson RA. PMID: 26230337.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    9. Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification. J Orthop Res. 2015 Aug; 33(8):1212-7. Wang L, Carroll DO, Liu X, Roth T, Kim H, Halloran B, Nissenson RA. PMID: 25773760.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    10. Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing. J Bone Miner Res. 2015 Oct; 30(10):1896-904. Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA. PMID: 25917236.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    11. Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts. Exp Cell Res. 2015 May 01; 333(2):289-302. Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao EC, Conklin BR, Nissenson RA. PMID: 25704759.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    12. Novel mouse model of spinal cord injury-induced heterotopic ossification. J Rehabil Res Dev. 2014; 51(7):1109-18. Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X. PMID: 25436890.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    13. A novel mouse model of trauma induced heterotopic ossification. J Orthop Res. 2014 Feb; 32(2):183-8. Liu X, Kang H, Shahnazari M, Kim H, Wang L, Larm O, Adolfsson L, Nissenson R, Halloran B. PMID: 24136593.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    14. CXCL12/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations. FASEB J. 2013 Sep; 27(9):3505-13. Shahnazari M, Chu V, Wronski TJ, Nissenson RA, Halloran BP. PMID: 23704087.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    15. Increased bone mass in mice lacking the adipokine apelin. Endocrinology. 2013 Jun; 154(6):2069-80. Wattanachanya L, Lu WD, Kundu RK, Wang L, Abbott MJ, O'Carroll D, Quertermous T, Nissenson RA. PMID: 23584856.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    16. Constitutive protein kinase A activity in osteocytes and late osteoblasts produces an anabolic effect on bone. Bone. 2013 Aug; 55(2):277-87. Kao RS, Abbott MJ, Louie A, O'Carroll D, Lu W, Nissenson R. PMID: 23583750.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    17. Cyclic AMP signaling in bone marrow stromal cells has reciprocal effects on the ability of mesenchymal stem cells to differentiate into mature osteoblasts versus mature adipocytes. Endocrine. 2012 Dec; 42(3):622-36. Kao R, Lu W, Louie A, Nissenson R. PMID: 22695986.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. Lamellar spacing in cuboid hydroxyapatite scaffolds regulates bone formation by human bone marrow stromal cells. Tissue Eng Part A. 2011 Jun; 17(11-12):1615-23. Mankani MH, Afghani S, Franco J, Launey M, Marshall S, Marshall GW, Nissenson R, Lee J, Tomsia AP, Saiz E. PMID: 21294634.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    19. Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation. J Bone Miner Res. 2011 Apr; 26(4):822-32. Millard SM, Louie AM, Wattanachanya L, Wronski TJ, Conklin BR, Nissenson RA. PMID: 20939063.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    20. Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation. J Bone Miner Res. 2010 Mar; 25(3):584-93. Hsiao EC, Boudignon BM, Halloran BP, Nissenson RA, Conklin BR. PMID: 20200944.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    21. Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation. Mol Endocrinol. 2010 Mar; 24(3):621-31. Hsiao EC, Millard SM, Louie A, Huang Y, Conklin BR, Nissenson RA. PMID: 20150184.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Engineering GPCR signaling pathways with RASSLs. Nat Methods. 2008 Aug; 5(8):673-8. Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. PMID: 18668035.
      View in: PubMed   Mentions: 106     Fields:    Translation:HumansAnimalsCells
    23. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1209-14. Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA. PMID: 18212126.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    24. Resolution dependence of the non-metric trabecular structure indices. Bone. 2008 Apr; 42(4):728-36. Sode M, Burghardt AJ, Nissenson RA, Majumdar S. PMID: 18276202.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    25. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. . 2008 Jan; 294(1):H205-12. McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ. PMID: 17965283.
      View in: PubMed   Mentions:
    26. PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res. 2004 Feb; 19(2):235-44. Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson RA. PMID: 14969393.
      View in: PubMed   Mentions: 87     Fields:    Translation:AnimalsCells
    27. Parathyroid hormone receptor recycling: role of receptor dephosphorylation and beta-arrestin. Mol Endocrinol. 2002 Dec; 16(12):2720-32. Chauvin S, Bencsik M, Bambino T, Nissenson RA. PMID: 12456793.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    28. Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. J Biol Chem. 2002 Mar 08; 277(10):8121-9. Vilardaga JP, Krasel C, Chauvin S, Bambino T, Lohse MJ, Nissenson RA. PMID: 11726668.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
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