Robert Nissenson, PhD

InstitutionUniversity of California San Francisco
Address4150 Clement St
San Francisco CA 94121
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    Collapse Biography 
    Collapse Education and Training
    Cornell University, Ithaca, NY06/1969Chemistry
    Northwestern University, Evanston, ILB.A.06/1971Biology
    Northwestern University Medical School, Chicago, ILPh.D.06/1976Physiology
    Mayo Clinic, Rochester, MN06/1977Postdoctoral Research in Endocrinology
    University of California, San Francisco, San Francisco, CA06/1980Postdoctoral Research in Endocrinology

    Collapse Research 
    Collapse Research Activities and Funding
    Inhibitory G protein (Gi) signaling in bone disease and repair
    VA I01BX003212Oct 1, 2016 - Sep 30, 2020
    Role: Principal Investigator
    Mechanisms Underlying Hormonal Regulation of Fracture Repair
    VA IP1BX001599Jan 1, 2012 - Dec 31, 2015
    Role: Co-Principal Investigator
    G Protein Signaling in Osteoblasts
    VA I01BX001496Oct 1, 2011 - Sep 30, 2015
    Role: Principal Investigator
    NIH/NIDDK R01DK072071Feb 1, 2006 - Dec 31, 2011
    Role: Principal Investigator
    G Protein Signaling in Osteoblasts
    NIH/NIDDK R56DK072071Apr 12, 2005 - Sep 30, 2011
    Role: Principal Investigator
    Role of Beta-Catenin Signaling in Osteoblast Function
    NIH/NIAMS R21AR051692Sep 30, 2004 - Jun 30, 2006
    Role: Principal Investigator
    2003 Bones &Teeth Gordon Conference
    NIH/NIAMS R13AR050390Aug 1, 2003 - Jul 31, 2004
    Role: Principal Investigator
    NIH/NIDDK R01DK042146May 1, 1991 - Apr 30, 1995
    Role: Principal Investigator
    NIH/NIDDK R01DK035323Apr 1, 1985 - Dec 31, 2004
    Role: Principal Investigator
    NIH/NIADDK R01AM035323Apr 1, 1985 - Mar 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson RA. Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice. Endocrinology. 2017 09 01; 158(9):2741-2753. PMID: 28911171.
      View in: PubMed
    2. Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA. Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice. Endocrinology. 2017 06 01; 158(6):1715-1726. PMID: 28407060.
      View in: PubMed
    3. Wang L, Roth T, Abbott M, Ho L, Wattanachanya L, Nissenson RA. Osteoblast-derived FGF9 regulates skeletal homeostasis. Bone. 2017 05; 98:18-25. PMID: 28189801.
      View in: PubMed
    4. Liu X, Ning AY, Chang NC, Kim H, Nissenson R, Wang L, Feeley BT. Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury. Muscles Ligaments Tendons J. 2016 Jan-Mar; 6(1):6-15. PMID: 27331027.
      View in: PubMed
    5. Shahnazari M, Turner RT, Iwaniec UT, Wronski TJ, Li M, Ferruzzi MG, Nissenson RA, Halloran BP. Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice. J Nutr Biochem. 2016 08; 34:73-82. PMID: 27239754.
      View in: PubMed
    6. Abbott MJ, Roth TM, Ho L, Wang L, O'Carroll D, Nissenson RA. Negative Skeletal Effects of Locally Produced Adiponectin. PLoS One. 2015; 10(7):e0134290. PMID: 26230337.
      View in: PubMed
    7. Wang L, Carroll DO, Liu X, Roth T, Kim H, Halloran B, Nissenson RA. Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification. J Orthop Res. 2015 Aug; 33(8):1212-7. PMID: 25773760.
      View in: PubMed
    8. Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA. Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing. J Bone Miner Res. 2015 Oct; 30(10):1896-904. PMID: 25917236.
      View in: PubMed
    9. Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao EC, Conklin BR, Nissenson RA. Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts. Exp Cell Res. 2015 May 01; 333(2):289-302. PMID: 25704759; PMCID: PMC4408231.
    10. Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X. Novel mouse model of spinal cord injury-induced heterotopic ossification. J Rehabil Res Dev. 2014; 51(7):1109-18. PMID: 25436890.
      View in: PubMed
    11. Liu X, Kang H, Shahnazari M, Kim H, Wang L, Larm O, Adolfsson L, Nissenson R, Halloran B. A novel mouse model of trauma induced heterotopic ossification. J Orthop Res. 2014 Feb; 32(2):183-8. PMID: 24136593.
      View in: PubMed
    12. Shahnazari M, Chu V, Wronski TJ, Nissenson RA, Halloran BP. CXCL12/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations. FASEB J. 2013 Sep; 27(9):3505-13. PMID: 23704087.
      View in: PubMed
    13. Wattanachanya L, Lu WD, Kundu RK, Wang L, Abbott MJ, O'Carroll D, Quertermous T, Nissenson RA. Increased bone mass in mice lacking the adipokine apelin. Endocrinology. 2013 Jun; 154(6):2069-80. PMID: 23584856; PMCID: PMC3740482.
    14. Kao RS, Abbott MJ, Louie A, O'Carroll D, Lu W, Nissenson R. Constitutive protein kinase A activity in osteocytes and late osteoblasts produces an anabolic effect on bone. Bone. 2013 Aug; 55(2):277-87. PMID: 23583750; PMCID: PMC3690773.
    15. Kao R, Lu W, Louie A, Nissenson R. Cyclic AMP signaling in bone marrow stromal cells has reciprocal effects on the ability of mesenchymal stem cells to differentiate into mature osteoblasts versus mature adipocytes. Endocrine. 2012 Dec; 42(3):622-36. PMID: 22695986; PMCID: PMC3509326.
    16. Mankani MH, Afghani S, Franco J, Launey M, Marshall S, Marshall GW, Nissenson R, Lee J, Tomsia AP, Saiz E. Lamellar spacing in cuboid hydroxyapatite scaffolds regulates bone formation by human bone marrow stromal cells. Tissue Eng Part A. 2011 Jun; 17(11-12):1615-23. PMID: 21294634; PMCID: PMC3098957.
    17. Millard SM, Louie AM, Wattanachanya L, Wronski TJ, Conklin BR, Nissenson RA. Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation. J Bone Miner Res. 2011 Apr; 26(4):822-32. PMID: 20939063; PMCID: PMC3179326.
    18. Hsiao EC, Boudignon BM, Halloran BP, Nissenson RA, Conklin BR. Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation. J Bone Miner Res. 2010 Mar; 25(3):584-93. PMID: 20200944; PMCID: PMC3153396.
    19. Hsiao EC, Millard SM, Louie A, Huang Y, Conklin BR, Nissenson RA. Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation. Mol Endocrinol. 2010 Mar; 24(3):621-31. PMID: 20150184; PMCID: PMC2840804.
    20. Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs. Nat Methods. 2008 Aug; 5(8):673-8. PMID: 18668035; PMCID: PMC2703467.
    21. Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1209-14. PMID: 18212126; PMCID: PMC2234117.
    22. Sode M, Burghardt AJ, Nissenson RA, Majumdar S. Resolution dependence of the non-metric trabecular structure indices. Bone. 2008 Apr; 42(4):728-36. PMID: 18276202; PMCID: PMC2329672.
    23. McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H205-12. PMID: 17965283; PMCID: PMC3372085.
    24. Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson RA. PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res. 2004 Feb; 19(2):235-44. PMID: 14969393.
      View in: PubMed
    25. Chauvin S, Bencsik M, Bambino T, Nissenson RA. Parathyroid hormone receptor recycling: role of receptor dephosphorylation and beta-arrestin. Mol Endocrinol. 2002 Dec; 16(12):2720-32. PMID: 12456793.
      View in: PubMed
    26. Vilardaga JP, Krasel C, Chauvin S, Bambino T, Lohse MJ, Nissenson RA. Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. J Biol Chem. 2002 Mar 08; 277(10):8121-9. PMID: 11726668.
      View in: PubMed