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Robert Nissenson, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Phone415-575-0553
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    Collapse Biography 
    Collapse Education and Training
    Cornell University, Ithaca, NY06/1969Chemistry
    Northwestern University, Evanston, ILB.A.06/1971Biology
    Northwestern University Medical School, Chicago, ILPh.D.06/1976Physiology
    Mayo Clinic, Rochester, MN06/1977Postdoctoral Research in Endocrinology
    University of California, San Francisco, San Francisco, CA06/1980Postdoctoral Research in Endocrinology

    Collapse Research 
    Collapse Research Activities and Funding
    Inhibitory G protein (Gi) signaling in bone disease and repair
    VA I01BX003212Oct 1, 2016 - Sep 30, 2020
    Role: Principal Investigator
    Mechanisms Underlying Hormonal Regulation of Fracture Repair
    VA IP1BX001599Jan 1, 2012 - Dec 31, 2015
    Role: Co-Principal Investigator
    G Protein Signaling in Osteoblasts
    VA I01BX001496Oct 1, 2011 - Sep 30, 2015
    Role: Principal Investigator
    G PROTEIN SIGNALING IN OSTEOBLASTS
    NIH/NIDDK R01DK072071Feb 1, 2006 - Dec 31, 2011
    Role: Principal Investigator
    G Protein Signaling in Osteoblasts
    NIH/NIDDK R56DK072071Apr 12, 2005 - Sep 30, 2011
    Role: Principal Investigator
    Role of Beta-Catenin Signaling in Osteoblast Function
    NIH/NIAMS R21AR051692Sep 30, 2004 - Jun 30, 2006
    Role: Principal Investigator
    2003 Bones &Teeth Gordon Conference
    NIH/NIAMS R13AR050390Aug 1, 2003 - Jul 31, 2004
    Role: Principal Investigator
    CLONING OF THE PARATHYROID HORMONE RECEPTOR CDNA
    NIH/NIDDK R01DK042146May 1, 1991 - Apr 30, 1995
    Role: Principal Investigator
    PARATHYROID HORMONE RECEPTORS IN KIDNEY AND BONE
    NIH/NIDDK R01DK035323Apr 1, 1985 - Dec 31, 2004
    Role: Principal Investigator
    PARATHYROID HORMONE RECEPTORS IN KIDNEY AND BONE
    NIH/NIADDK R01AM035323Apr 1, 1985 - Mar 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nat Commun. 2019 01 11; 10(1):163. PMID: 30635563.
      View in: PubMed
    2. Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson RA. Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice. Endocrinology. 2017 09 01; 158(9):2741-2753. PMID: 28911171.
      View in: PubMed
    3. Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA. Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice. Endocrinology. 2017 06 01; 158(6):1715-1726. PMID: 28407060.
      View in: PubMed
    4. Wang L, Roth T, Abbott M, Ho L, Wattanachanya L, Nissenson RA. Osteoblast-derived FGF9 regulates skeletal homeostasis. Bone. 2017 05; 98:18-25. PMID: 28189801.
      View in: PubMed
    5. Hsiao EC, Millard SM, Nissenson RA. Gs/Gi Regulation of Bone Cell Differentiation: Review and Insights from Engineered Receptors. Horm Metab Res. 2016 Nov; 48(11):689-699. PMID: 27643449.
      View in: PubMed
    6. Liu X, Ning AY, Chang NC, Kim H, Nissenson R, Wang L, Feeley BT. Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury. Muscles Ligaments Tendons J. 2016 Jan-Mar; 6(1):6-15. PMID: 27331027.
      View in: PubMed
    7. Shahnazari M, Turner RT, Iwaniec UT, Wronski TJ, Li M, Ferruzzi MG, Nissenson RA, Halloran BP. Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice. J Nutr Biochem. 2016 08; 34:73-82. PMID: 27239754.
      View in: PubMed
    8. Abbott MJ, Roth TM, Ho L, Wang L, O'Carroll D, Nissenson RA. Negative Skeletal Effects of Locally Produced Adiponectin. PLoS One. 2015; 10(7):e0134290. PMID: 26230337.
      View in: PubMed
    9. Wang L, Carroll DO, Liu X, Roth T, Kim H, Halloran B, Nissenson RA. Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification. J Orthop Res. 2015 Aug; 33(8):1212-7. PMID: 25773760.
      View in: PubMed
    10. Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA. Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing. J Bone Miner Res. 2015 Oct; 30(10):1896-904. PMID: 25917236.
      View in: PubMed
    11. Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao EC, Conklin BR, Nissenson RA. Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts. Exp Cell Res. 2015 May 01; 333(2):289-302. PMID: 25704759; PMCID: PMC4408231.
      View in: PubMed, PubMed Central
    12. Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X. Novel mouse model of spinal cord injury-induced heterotopic ossification. J Rehabil Res Dev. 2014; 51(7):1109-18. PMID: 25436890.
      View in: PubMed
    13. Liu X, Kang H, Shahnazari M, Kim H, Wang L, Larm O, Adolfsson L, Nissenson R, Halloran B. A novel mouse model of trauma induced heterotopic ossification. J Orthop Res. 2014 Feb; 32(2):183-8. PMID: 24136593.
      View in: PubMed
    14. Shahnazari M, Chu V, Wronski TJ, Nissenson RA, Halloran BP. CXCL12/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations. FASEB J. 2013 Sep; 27(9):3505-13. PMID: 23704087.
      View in: PubMed
    15. Wattanachanya L, Lu WD, Kundu RK, Wang L, Abbott MJ, O'Carroll D, Quertermous T, Nissenson RA. Increased bone mass in mice lacking the adipokine apelin. Endocrinology. 2013 Jun; 154(6):2069-80. PMID: 23584856; PMCID: PMC3740482.
      View in: PubMed, PubMed Central
    16. Kao RS, Abbott MJ, Louie A, O'Carroll D, Lu W, Nissenson R. Constitutive protein kinase A activity in osteocytes and late osteoblasts produces an anabolic effect on bone. Bone. 2013 Aug; 55(2):277-87. PMID: 23583750; PMCID: PMC3690773.
      View in: PubMed, PubMed Central
    17. Kao R, Lu W, Louie A, Nissenson R. Cyclic AMP signaling in bone marrow stromal cells has reciprocal effects on the ability of mesenchymal stem cells to differentiate into mature osteoblasts versus mature adipocytes. Endocrine. 2012 Dec; 42(3):622-36. PMID: 22695986; PMCID: PMC3509326.
      View in: PubMed, PubMed Central
    18. Kazakia GJ, Speer D, Shanbhag S, Majumdar S, Conklin BR, Nissenson RA, Hsiao EC. Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor. Calcif Tissue Int. 2011 Jul; 89(1):10-20. PMID: 21526395; PMCID: PMC3110278.
      View in: PubMed, PubMed Central
    19. Mankani MH, Afghani S, Franco J, Launey M, Marshall S, Marshall GW, Nissenson R, Lee J, Tomsia AP, Saiz E. Lamellar spacing in cuboid hydroxyapatite scaffolds regulates bone formation by human bone marrow stromal cells. Tissue Eng Part A. 2011 Jun; 17(11-12):1615-23. PMID: 21294634; PMCID: PMC3098957.
      View in: PubMed, PubMed Central
    20. Millard SM, Louie AM, Wattanachanya L, Wronski TJ, Conklin BR, Nissenson RA. Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation. J Bone Miner Res. 2011 Apr; 26(4):822-32. PMID: 20939063; PMCID: PMC3179326.
      View in: PubMed, PubMed Central
    21. Hsiao EC, Boudignon BM, Halloran BP, Nissenson RA, Conklin BR. Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation. J Bone Miner Res. 2010 Mar; 25(3):584-93. PMID: 20200944; PMCID: PMC3153396.
      View in: PubMed, PubMed Central
    22. Hsiao EC, Millard SM, Louie A, Huang Y, Conklin BR, Nissenson RA. Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation. Mol Endocrinol. 2010 Mar; 24(3):621-31. PMID: 20150184; PMCID: PMC2840804.
      View in: PubMed, PubMed Central
    23. Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs. Nat Methods. 2008 Aug; 5(8):673-8. PMID: 18668035; PMCID: PMC2703467.
      View in: PubMed, PubMed Central
    24. Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1209-14. PMID: 18212126; PMCID: PMC2234117.
      View in: PubMed, PubMed Central
    25. Sode M, Burghardt AJ, Nissenson RA, Majumdar S. Resolution dependence of the non-metric trabecular structure indices. Bone. 2008 Apr; 42(4):728-36. PMID: 18276202; PMCID: PMC2329672.
      View in: PubMed, PubMed Central
    26. Peng J, Bencsik M, Louie A, Lu W, Millard S, Nguyen P, Burghardt A, Majumdar S, Wronski TJ, Halloran B, Conklin BR, Nissenson RA. Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinology. 2008 Mar; 149(3):1329-37. PMID: 18048501; PMCID: PMC2275363.
      View in: PubMed, PubMed Central
    27. McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H205-12. PMID: 17965283; PMCID: PMC3372085.
      View in: PubMed, PubMed Central
    28. Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson RA. PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res. 2004 Feb; 19(2):235-44. PMID: 14969393.
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    29. Chauvin S, Bencsik M, Bambino T, Nissenson RA. Parathyroid hormone receptor recycling: role of receptor dephosphorylation and beta-arrestin. Mol Endocrinol. 2002 Dec; 16(12):2720-32. PMID: 12456793.
      View in: PubMed
    30. Vilardaga JP, Krasel C, Chauvin S, Bambino T, Lohse MJ, Nissenson RA. Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. J Biol Chem. 2002 Mar 08; 277(10):8121-9. PMID: 11726668.
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    31. Vilardaga JP, Lin I, Nissenson RA. Analysis of parathyroid hormone (PTH)/secretin receptor chimeras differentiates the role of functional domains in the pth/ pth-related peptide (PTHrP) receptor on hormone binding and receptor activation. Mol Endocrinol. 2001 Jul; 15(7):1186-99. PMID: 11435617.
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    32. Vilardaga JP, Frank M, Krasel C, Dees C, Nissenson RA, Lohse MJ. Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein. J Biol Chem. 2001 Sep 07; 276(36):33435-43. PMID: 11387315.
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    33. Gabarin N, Gavish H, Muhlrad A, Chen YC, Namdar-Attar M, Nissenson RA, Chorev M, Bab I. Mitogenic G(i) protein-MAP kinase signaling cascade in MC3T3-E1 osteogenic cells: activation by C-terminal pentapeptide of osteogenic growth peptide [OGP(10-14)] and attenuation of activation by cAMP. J Cell Biochem. 2001; 81(4):594-603. PMID: 11329614.
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    34. Nissenson RA. Parathyroid hormone-related protein. Rev Endocr Metab Disord. 2000 Nov; 1(4):343-52. PMID: 11706748.
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    35. Bliziotes M, Gunness M, Zhang X, Nissenson R, Wiren K. Reduced G-protein-coupled-receptor kinase 2 activity results in impairment of osteoblast function. Bone. 2000 Sep; 27(3):367-73. PMID: 10962347.
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    36. Turner PR, Mefford S, Christakos S, Nissenson RA. Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein (PTHrP). Mol Endocrinol. 2000 Feb; 14(2):241-54. PMID: 10674397.
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    37. Sheikh SP, Vilardarga JP, Baranski TJ, Lichtarge O, Iiri T, Meng EC, Nissenson RA, Bourne HR. Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. J Biol Chem. 1999 Jun 11; 274(24):17033-41. PMID: 10358054.
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    38. Huang Z, Bambino T, Chen Y, Lameh J, Nissenson RA. Role of signal transduction in internalization of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein. Endocrinology. 1999 Mar; 140(3):1294-300. PMID: 10067856.
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    39. Malecz N, Bambino T, Bencsik M, Nissenson RA. Identification of phosphorylation sites in the G protein-coupled receptor for parathyroid hormone. Receptor phosphorylation is not required for agonist-induced internalization. Mol Endocrinol. 1998 Dec; 12(12):1846-56. PMID: 9849959.
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    40. Nissenson RA. Parathyroid hormone (PTH)/PTHrP receptor mutations in human chondrodysplasia. Endocrinology. 1998 Dec; 139(12):4753-5. PMID: 9832410.
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    41. Turner PR, Mefford S, Bambino T, Nissenson RA. Transmembrane residues together with the amino terminus limit the response of the parathyroid hormone (PTH) 2 receptor to PTH-related peptide. J Biol Chem. 1998 Feb 13; 273(7):3830-7. PMID: 9461563.
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    42. Schipani E, Jensen GS, Pincus J, Nissenson RA, Gardella TJ, Jüppner H. Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia. Mol Endocrinol. 1997 Jun; 11(7):851-8. PMID: 9178745.
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    43. Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Nissenson RA, Shoback DM. The N-terminal region of the third intracellular loop of the parathyroid hormone (PTH)/PTH-related peptide receptor is critical for coupling to cAMP and inositol phosphate/Ca2+ signal transduction pathways. J Biol Chem. 1996 Dec 27; 271(52):33382-9. PMID: 8969199.
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    44. Lee K, Lanske B, Karaplis AC, Deeds JD, Kohno H, Nissenson RA, Kronenberg HM, Segre GV. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology. 1996 Nov; 137(11):5109-18. PMID: 8895385.
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    45. Jobert AS, Fernandes I, Turner G, Coureau C, Prie D, Nissenson RA, Friedlander G, Silve C. Expression of alternatively spliced isoforms of the parathyroid hormone (PTH)/PTH-related peptide receptor messenger RNA in human kidney and bone cells. Mol Endocrinol. 1996 Sep; 10(9):1066-76. PMID: 8885241.
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    46. Lane NE, Kimmel DB, Nilsson MH, Cohen FE, Newton S, Nissenson RA, Strewler GJ. Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model. J Bone Miner Res. 1996 May; 11(5):614-25. PMID: 9157776.
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    47. Blind E, Bambino T, Huang Z, Bliziotes M, Nissenson RA. Phosphorylation of the cytoplasmic tail of the PTH/PTHrP receptor. J Bone Miner Res. 1996 May; 11(5):578-86. PMID: 9157772.
      View in: PubMed
    48. Turner PR, Bambino T, Nissenson RA. A putative selectivity filter in the G-protein-coupled receptors for parathyroid hormone and secretion. J Biol Chem. 1996 Apr 19; 271(16):9205-8. PMID: 8621578.
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    49. Turner PR, Bambino T, Nissenson RA. Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor. Mol Endocrinol. 1996 Feb; 10(2):132-9. PMID: 8825553.
      View in: PubMed
    50. Blind E, Bambino T, Nissenson RA. Agonist-stimulated phosphorylation of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein. Endocrinology. 1995 Oct; 136(10):4271-7. PMID: 7664644.
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    51. Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Shoback DM, Nissenson RA. Mutational analysis of the cytoplasmic tail of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein: effects on receptor expression and signaling. Mol Endocrinol. 1995 Sep; 9(9):1240-9. PMID: 7491116.
      View in: PubMed
    52. Funk JL, Lausier J, Moser AH, Shigenaga JK, Huling S, Nissenson RA, Strewler GJ, Grunfeld C, Feingold KR. Endotoxin induces parathyroid hormone-related protein gene expression in splenic stromal and smooth muscle cells, not in splenic lymphocytes. Endocrinology. 1995 Aug; 136(8):3412-21. PMID: 7628377.
      View in: PubMed
    53. Huang Z, Chen Y, Nissenson RA. The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis. J Biol Chem. 1995 Jan 06; 270(1):151-6. PMID: 7814366.
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    54. Schermer DT, Bradley MS, Bambino TH, Nissenson RA, Strewler GJ. Functional properties of a synthetic chicken parathyroid hormone-related protein 1-36 fragment. J Bone Miner Res. 1994 Jul; 9(7):1041-6. PMID: 7942150.
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    55. Babich M, Alford GE, Nissenson RA. A novel phospholipase C inhibitor and phorbol esters reveal selective regulation of thrombin- and parathyroid hormone-stimulated signaling pathways in rat osteosarcoma cells. J Pharmacol Exp Ther. 1994 Apr; 269(1):172-7. PMID: 8169821.
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    56. Strewler GJ, Budayr AA, Clark OH, Nissenson RA. Production of parathyroid hormone by a malignant nonparathyroid tumor in a hypercalcemic patient. J Clin Endocrinol Metab. 1993 May; 76(5):1373-5. PMID: 7684395.
      View in: PubMed
    57. Nissenson RA, Huang Z, Blind E, Shoback D. Structure and function of the receptor for parathyroid hormone and parathyroid hormone-related protein. Receptor. 1993; 3(3):193-202. PMID: 8167570.
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    58. Strewler GJ, Chan SD, Globus RK, Schermer DT, Nissenson RA. Actions of parathyroid hormone-related protein as an embryonic differentiation factor. J Endocrinol Invest. 1992; 15(9 Suppl 6):57-62. PMID: 1300340.
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    59. Klein RF, Nissenson RA, Strewler GJ. Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones. J Pharmacol Exp Ther. 1991 Sep; 258(3):877-81. PMID: 1653845.
      View in: PubMed
    60. Babich M, Choi H, Johnson RM, King KL, Alford GE, Nissenson RA. Thrombin and parathyroid hormone mobilize intracellular calcium in rat osteosarcoma cells by distinct pathways. Endocrinology. 1991 Sep; 129(3):1463-70. PMID: 1874183.
      View in: PubMed
    61. Karpf DB, Bambino T, Alford G, Nissenson RA. Features of the renal parathyroid hormone-parathyroid hormone-related protein receptor derived from structural studies of receptor fragments. J Bone Miner Res. 1991 Feb; 6(2):173-82. PMID: 1851372.
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    62. Schermer DT, Chan SD, Bruce R, Nissenson RA, Wood WI, Strewler GJ. Chicken parathyroid hormone-related protein and its expression during embryologic development. J Bone Miner Res. 1991 Feb; 6(2):149-55. PMID: 1709333.
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    63. Cohen FE, Strewler GJ, Bradley MS, Carlquist M, Nilsson M, Ericsson M, Ciardelli TL, Nissenson RA. Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone. J Biol Chem. 1991 Jan 25; 266(3):1997-2004. PMID: 1846369.
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    64. Pun KK, Ho PW, Nissenson RA, Arnaud CD. Desensitization of parathyroid hormone receptors on cultured bone cells. J Bone Miner Res. 1990 Dec; 5(12):1193-200. PMID: 1963732.
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    65. Strewler GJ, Nissenson RA. Hypercalcemia in malignancy. West J Med. 1990 Dec; 153(6):635-40. PMID: 2293469; PMCID: PMC1002641.
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    66. Chan SD, Strewler GJ, Nissenson RA. Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells. J Biol Chem. 1990 Nov 25; 265(33):20081-4. PMID: 2122968.
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    67. Chan SD, Strewler GJ, King KL, Nissenson RA. Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells. Mol Endocrinol. 1990 Apr; 4(4):638-46. PMID: 2177844.
      View in: PubMed
    68. Babich M, King KL, Nissenson RA. Thrombin stimulates inositol phosphate production and intracellular free calcium by a pertussis toxin-insensitive mechanism in osteosarcoma cells. Endocrinology. 1990 Feb; 126(2):948-54. PMID: 2153536.
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    69. Strewler GJ, Nissenson RA. Peptide mediators of hypercalcemia in malignancy. Annu Rev Med. 1990; 41:35-44. PMID: 2184736.
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    70. Budayr AA, Nissenson RA, Klein RF, Pun KK, Clark OH, Diep D, Arnaud CD, Strewler GJ. Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia. Ann Intern Med. 1989 Nov 15; 111(10):807-12. PMID: 2817628.
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    71. Budayr AA, Halloran BP, King JC, Diep D, Nissenson RA, Strewler GJ. High levels of a parathyroid hormone-like protein in milk. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):7183-5. PMID: 2550932; PMCID: PMC298020.
      View in: PubMed, PubMed Central
    72. Babich M, King KL, Nissenson RA. G protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes. J Bone Miner Res. 1989 Aug; 4(4):549-56. PMID: 2554686.
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    73. Karpf DB, Arnaud CD, Bambino T, Duffy D, King KL, Winer J, Nissenson RA. Structural properties of the renal parathyroid hormone receptor: hydrodynamic analysis and protease sensitivity. Endocrinology. 1988 Dec; 123(6):2611-20. PMID: 2848681.
      View in: PubMed
    74. Nissenson RA, Diep D, Strewler GJ. Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. J Biol Chem. 1988 Sep 15; 263(26):12866-71. PMID: 2843501.
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    75. Pun KK, Arnaud CD, Nissenson RA. Parathyroid hormone receptors in human dermal fibroblasts: structural and functional characterization. J Bone Miner Res. 1988 Aug; 3(4):453-60. PMID: 2851922.
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    76. Thiede MA, Strewler GJ, Nissenson RA, Rosenblatt M, Rodan GA. Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4605-9. PMID: 3290897; PMCID: PMC280483.
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    77. Klein RF, Nissenson RA, Strewler GJ. Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro. Bone Miner. 1988 Jul; 4(3):247-56. PMID: 2847839.
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    78. Karpf DB, Arnaud CD, King K, Bambino T, Winer J, Nyiredy K, Nissenson RA. The canine renal parathyroid hormone receptor is a glycoprotein: characterization and partial purification. Biochemistry. 1987 Dec 01; 26(24):7825-33. PMID: 2827760.
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    79. Strewler GJ, Stern PH, Jacobs JW, Eveloff J, Klein RF, Leung SC, Rosenblatt M, Nissenson RA. Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. J Clin Invest. 1987 Dec; 80(6):1803-7. PMID: 3680530; PMCID: PMC442457.
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    80. Forero MS, Klein RF, Nissenson RA, Nelson K, Heath H, Arnaud CD, Riggs BL. Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women. J Bone Miner Res. 1987 Oct; 2(5):363-6. PMID: 3455620.
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    81. Nissenson RA, Karpf D, Bambino T, Winer J, Canga M, Nyiredy K, Arnaud CD. Covalent labeling of a high-affinity, guanyl nucleotide sensitive parathyroid hormone receptor in canine renal cortex. Biochemistry. 1987 Apr 07; 26(7):1874-8. PMID: 3036211.
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    82. Klein RF, Strewler GJ, Leung SC, Nissenson RA. Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity. Endocrinology. 1987 Feb; 120(2):504-11. PMID: 3026777.
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    83. Strewler GJ, Nissenson RA. Nonparathyroid hypercalcemia. Adv Intern Med. 1987; 32:235-58. PMID: 3030065.
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    84. Teitelbaum AP, Nissenson RA, Zitzner LA, Simon K. Dual regulation of PTH-stimulated adenylate cyclase activity by GTP. Am J Physiol. 1986 Nov; 251(5 Pt 2):F858-64. PMID: 3777181.
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    85. Strewler GJ, Wronski TJ, Halloran BP, Miller SC, Leung SC, Williams RD, Nissenson RA. Pathogenesis of hypercalcemia in nude mice bearing a human renal carcinoma. Endocrinology. 1986 Jul; 119(1):303-10. PMID: 3013591.
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    86. Nissenson RA, Mann E, Winer J, Teitelbaum AP, Arnaud CD. Solubilization of a guanine nucleotide-sensitive parathyroid hormone-receptor complex from canine renal cortex. Endocrinology. 1986 Mar; 118(3):932-9. PMID: 3004900.
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    87. Nissenson RA, Mann E, Winer J, Teitelbaum A, Arnaud CD. Solubilization of a guanine nucleotide-sensitive parathyroid hormone-receptor complex from canine renal cortex. Adv Exp Med Biol. 1986; 208:329-43. PMID: 3031942.
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    88. Calvo MS, Fryer MJ, Laakso KJ, Nissenson RA, Price PA, Murray TM, Heath H. Structural requirements for parathyroid hormone action in mature bone. Effects on release of cyclic adenosine monophosphate and bone gamma-carboxyglutamic acid-containing protein from perfused rat hindquarters. J Clin Invest. 1985 Dec; 76(6):2348-54. PMID: 3001148; PMCID: PMC424371.
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    89. Stern PH, Krieger NS, Nissenson RA, Williams RD, Winkler ME, Derynck R, Strewler GJ. Human transforming growth factor-alpha stimulates bone resorption in vitro. J Clin Invest. 1985 Nov; 76(5):2016-9. PMID: 3877079; PMCID: PMC424268.
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    90. Nissenson RA, Strewler GJ, Williams RD, Leung SC. Activation of the parathyroid hormone receptor-adenylate cyclase system in osteosarcoma cells by a human renal carcinoma factor. Cancer Res. 1985 Nov; 45(11 Pt 1):5358-63. PMID: 2996759.
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    91. Toffaletti J, Nissenson R, Endres D, McGarry E, Mogollon G. Influence of continuous infusion of citrate on responses of immunoreactive parathyroid hormone, calcium and magnesium components, and other electrolytes in normal adults during plateletapheresis. J Clin Endocrinol Metab. 1985 May; 60(5):874-9. PMID: 3980672.
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    92. Nissenson RA, Teitelbaum AP, Arnaud CD. Assay for parathyroid hormone receptors. Methods Enzymol. 1985; 109:48-56. PMID: 2985929.
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    93. Teitelbaum AP, Nissenson RA, Arnaud CD. Assays for calcitonin receptors. Methods Enzymol. 1985; 109:40-8. PMID: 2985927.
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    94. Clark OH, Gerend PL, Nissenson RA. Mechanisms for increased adenylate cyclase responsiveness to TSH in neoplastic human thyroid tissue. World J Surg. 1984 Aug; 8(4):466-73. PMID: 6091347.
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    95. Hsu FS, Clark OH, Serata TY, Nissenson RA. Rapid localization of parathyroid tumors by selective venous catheterization and parathyroid hormone bioassay. Surgery. 1983 Dec; 94(6):873-6. PMID: 6648799.
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    96. Zanelli JM, Kent JC, Rafferty B, Nissenson RA, Nice EC, Capp MW, O'Hare MJ. High-performance liquid chromatographic methods for the analysis of human parathyroid hormone in reference standards, parathyroid tissue and biological fluids. J Chromatogr. 1983 Aug 12; 276(1):55-68. PMID: 6672025.
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    97. Mahoney CA, Nissenson RA. Canine renal receptors for parathyroid hormone. Down-regulation in vivo by exogenous parathyroid hormone. J Clin Invest. 1983 Aug; 72(2):411-21. PMID: 6308053; PMCID: PMC1129199.
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    98. Clark OH, Gerend PL, Goretzki P, Nissenson RA. Characterization of the thyrotropin receptor-adenylate cyclase system in neoplastic human thyroid tissue. J Clin Endocrinol Metab. 1983 Jul; 57(1):140-7. PMID: 6304132.
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    99. Fox J, Scott M, Nissenson RA, Heath H. Effect of plasma calcium concentration on the metabolic clearance rate of parathyroid hormone in the dog. J Lab Clin Med. 1983 Jul; 102(1):70-7. PMID: 6854136.
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    100. Law WM, Nissenson RA, Klee GG, Heath H. Preparation of synthetic bovine parathyroid hormone fragment 1-34 for parenteral use in human studies. J Clin Endocrinol Metab. 1983 Jun; 56(6):1335-7. PMID: 6841565.
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    101. Yanagawa N, Nissenson RA, Edwards B, Yeung P, Trizna W, Fine LG. Functional profile of the isolated uremic nephron: intrinsic adaptation of phosphate transport in the rabbit proximal tubule. Kidney Int. 1983 May; 23(5):674-83. PMID: 6876563.
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    102. Strewler GJ, Williams RD, Nissenson RA. Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors. J Clin Invest. 1983 Mar; 71(3):769-74. PMID: 6298282; PMCID: PMC436928.
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    103. Teitelbaum AP, Nissenson RA, Arnaud CD. Coupling of the canine renal parathyroid hormone receptor to adenylate cyclase: modulation by guanyl nucleotides and N-ethylmaleimide. Endocrinology. 1982 Nov; 111(5):1524-33. PMID: 6290186.
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    104. Nissenson RA. Functional properties of parathyroid hormone receptors. Miner Electrolyte Metab. 1982 Sep-Oct; 8(3-4):151-8. PMID: 6300627.
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    105. Clark OH, Gerend PL, Nissenson RA. Thyrotropin binding and adenylate cyclase activation in normal and neoplastic human thyroid tissue: lack of effect of thyroglobulin. J Clin Endocrinol Metab. 1982 Jun; 54(6):1157-63. PMID: 7076796.
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    106. Draper MW, Nissenson RA, Winer J, Ramachandran J, Arnaud CD. Photoaffinity labeling of the canine renal receptor for parathyroid hormone. J Biol Chem. 1982 Apr 10; 257(7):3714-8. PMID: 6277947.
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    107. Nissenson RA, Abbott SR, Pua K, Zitzner L, Teitelbaum AP, Clark OH. Assessment of biologically active parathyroid hormone in hyperparathyroid man. Adv Exp Med Biol. 1982; 151:549-59. PMID: 7180664.
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    108. Teitelbaum AP, Pliam NB, Silve C, Abbott SR, Nissenson RA, Arnaud CD. Functional properties of parathyroid hormone receptors in kidney and bone. Adv Exp Med Biol. 1982; 151:535-48. PMID: 6295095.
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    109. Clark OH, Gerend PL, Cote TC, Nissenson RA. Thyrotropin binding and adenylate cyclase stimulation in thyroid neoplasms. Surgery. 1981 Aug; 90(2):252-61. PMID: 6266060.
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    110. Nissenson RA, Nyiredy KO, Arnaud CD. Guanyl nucleotide potentiation of parathyroid hormone-stimulated adenylate cyclase in chicken renal plasma membranes: a receptor-independent effect. Endocrinology. 1981 May; 108(5):1949-53. PMID: 6260469.
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    111. Nissenson RA, Abbott SR, Teitelbaum AP, Clark OH, Arnaud CD. Endogenous biologically active human parathyroid hormone: measurement by a guanyl nucleotide-amplified renal adenylate cyclase assay. J Clin Endocrinol Metab. 1981 May; 52(5):840-6. PMID: 7228991.
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    112. Nissenson RA, Flouret G, Hechter O. Oxytocin receptors coupled to uterine contraction in estrogen-dominated rabbits. Biochim Biophys Acta. 1980 Mar 03; 628(2):209-19. PMID: 6244002.
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    113. Nissenson RA, Kugai N, Arnaud CD. The renal parathyroid hormone receptor-adenylate cyclase system in vitro and in vivo. Prog Biochem Pharmacol. 1980; 17:173-81. PMID: 6259654.
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    114. Abbott SR, Nissenson RA, Teitelbaum AP, Clark OH, Arnaud CD. Biologically active parathyroid hormone in human hyperparathyroid serum: assay and characterization. Trans Assoc Am Physicians. 1980; 93:192-202. PMID: 7245574.
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    115. Nissenson RA, Kugai N, Arnaud CD. The parathyroid hormone receptor-adenylate cyclase system in chicken kidney. Adv Exp Med Biol. 1980; 128:523-36. PMID: 6252762.
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    116. Nissenson RA, Arnaud CD. Properties of the parathyroid hormone receptor-adenylate cyclase system in chicken renal plasma membranes. J Biol Chem. 1979 Mar 10; 254(5):1469-75. PMID: 216694.
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    117. Nissenson R, Fluoret G, Hechter O. Opposing effects of estradiol and progesterone on oxytocin receptors in rabbit uterus. Proc Natl Acad Sci U S A. 1978 Apr; 75(4):2044-8. PMID: 205880; PMCID: PMC392480.
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    118. Kugai N, Dorantes L, Nissenson R, Arnaud CD. Parathyroid hormone receptors and stimulation of renal cyclic 3', 5' AMP in vitro: physiological relevance? Adv Exp Med Biol. 1978; 103:537-42. PMID: 213954.
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