Robert Nissenson • UCSF Profiles

Robert Nissenson, PhD

Title(s)	Professor, Medicine
School	School of Medicine
Address	4150 Clement St San Francisco CA 94121
Phone	415-750-2089
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Biography

Education and Training

Cornell University, Ithaca, NY		06/1969	Chemistry
Northwestern University, Evanston, IL	B.A.	06/1971	Biology
Northwestern University Medical School, Chicago, IL	Ph.D.	06/1976	Physiology
Mayo Clinic, Rochester, MN		06/1977	Postdoctoral Research in Endocrinology
University of California, San Francisco, San Francisco, CA		06/1980	Postdoctoral Research in Endocrinology

Research

Research Activities and Funding

Inhibitory G protein (Gi) signaling in bone disease and repair
NIH I01BX003212Oct 1, 2016 - Mar 31, 2021
Role: Principal Investigator

Mechanisms Underlying Hormonal Regulation of Fracture Repair
NIH IP1BX001599Jan 1, 2012 - Dec 31, 2015
Role: Co-Principal Investigator

G Protein Signaling in Osteoblasts
NIH I01BX001496Oct 1, 2011 - Sep 30, 2015
Role: Principal Investigator

G PROTEIN SIGNALING IN OSTEOBLASTS
NIH R01DK072071Feb 1, 2006 - Dec 31, 2011
Role: Principal Investigator

G Protein Signaling in Osteoblasts
NIH R56DK072071Apr 12, 2005 - Sep 30, 2011
Role: Principal Investigator

Role of Beta-Catenin Signaling in Osteoblast Function
NIH R21AR051692Sep 30, 2004 - Jun 30, 2006
Role: Principal Investigator

2003 Bones &Teeth Gordon Conference
NIH R13AR050390Aug 1, 2003 - Jul 31, 2004
Role: Principal Investigator

CLONING OF THE PARATHYROID HORMONE RECEPTOR CDNA
NIH R01DK042146May 1, 1991 - Apr 30, 1995
Role: Principal Investigator

PARATHYROID HORMONE RECEPTORS IN KIDNEY AND BONE
NIH R01DK035323Apr 1, 1985 - Dec 31, 2004
Role: Principal Investigator

PARATHYROID HORMONE RECEPTORS IN KIDNEY AND BONE
NIH R01AM035323Apr 1, 1985 - Mar 31, 1988
Role: Principal Investigator

ORNG Applications

Academic Senate

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Female-Specific Role of Progranulin to Suppress Bone Formation. Endocrinology. 2019 09 01; 160(9):2024-2037. Wang L, Roth T, Nakamura MC, Nissenson RA. PMID: 31237618.

View in: PubMed Mentions: 2 Fields:
End Endocrinology
Translation:Animals
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nat Commun. 2019 01 11; 10(1):163. Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA. PMID: 30635563.

View in: PubMed Mentions: 13 Fields:
Bio Biology Sci Science
Translation:Animals
Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice. Endocrinology. 2017 09 01; 158(9):2741-2753. Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson RA. PMID: 28911171.

View in: PubMed Mentions: 8 Fields:
End Endocrinology
Translation:Animals Cells
Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice. Endocrinology. 2017 06 01; 158(6):1715-1726. Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA. PMID: 28407060.

View in: PubMed Mentions: 3 Fields:
End Endocrinology
Translation:Animals Cells
Osteoblast-derived FGF9 regulates skeletal homeostasis. Bone. 2017 05; 98:18-25. Wang L, Roth T, Abbott M, Ho L, Wattanachanya L, Nissenson RA. PMID: 28189801.

View in: PubMed Mentions: 5 Fields:
Met Metabolism Ort Orthopedics
Translation:Animals Cells
Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury. Muscles Ligaments Tendons J. 2016 Jan-Mar; 6(1):6-15. Liu X, Ning AY, Chang NC, Kim H, Nissenson R, Wang L, Feeley BT. PMID: 27331027.

View in: PubMed Mentions:
Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice. J Nutr Biochem. 2016 08; 34:73-82. Shahnazari M, Turner RT, Iwaniec UT, Wronski TJ, Li M, Ferruzzi MG, Nissenson RA, Halloran BP. PMID: 27239754.

View in: PubMed Mentions: 9 Fields:
Bio Biochemistry Nut Nutritional Sciences
Translation:Animals Cells
Negative Skeletal Effects of Locally Produced Adiponectin. PLoS One. 2015; 10(7):e0134290. Abbott MJ, Roth TM, Ho L, Wang L, O'Carroll D, Nissenson RA. PMID: 26230337.

View in: PubMed Mentions: 7 Fields:
Med Medicine (General)Sci Science
Translation:Animals Cells
Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification. J Orthop Res. 2015 Aug; 33(8):1212-7. Wang L, Carroll DO, Liu X, Roth T, Kim H, Halloran B, Nissenson RA. PMID: 25773760.

View in: PubMed Mentions: 1 Fields:
Ort Orthopedics
Translation:Animals Cells
Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing. J Bone Miner Res. 2015 Oct; 30(10):1896-904. Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA. PMID: 25917236.

View in: PubMed Mentions: 8 Fields:
Met Metabolism Ort Orthopedics
Translation:Animals Cells
Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts. Exp Cell Res. 2015 May 01; 333(2):289-302. Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao EC, Conklin BR, Nissenson RA. PMID: 25704759.

View in: PubMed Mentions: 1 Fields:
Cel Cell Biology
Translation:Animals Cells
Novel mouse model of spinal cord injury-induced heterotopic ossification. J Rehabil Res Dev. 2014; 51(7):1109-18. Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X. PMID: 25436890.

View in: PubMed Mentions: 8 Fields:
Bio Biomedical Engineering Phy Physical and Rehabilitation Me
Translation:Animals Cells
A novel mouse model of trauma induced heterotopic ossification. J Orthop Res. 2014 Feb; 32(2):183-8. Liu X, Kang H, Shahnazari M, Kim H, Wang L, Larm O, Adolfsson L, Nissenson R, Halloran B. PMID: 24136593.

View in: PubMed Mentions: 11 Fields:
Ort Orthopedics
Translation:Animals
CXCL12/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations. FASEB J. 2013 Sep; 27(9):3505-13. Shahnazari M, Chu V, Wronski TJ, Nissenson RA, Halloran BP. PMID: 23704087.

View in: PubMed Mentions: 21 Fields:
Bio Biology Phy Physiology
Translation:Animals Cells
Increased bone mass in mice lacking the adipokine apelin. Endocrinology. 2013 Jun; 154(6):2069-80. Wattanachanya L, Lu WD, Kundu RK, Wang L, Abbott MJ, O'Carroll D, Quertermous T, Nissenson RA. PMID: 23584856.

View in: PubMed Mentions: 12 Fields:
End Endocrinology
Translation:Animals Cells
Constitutive protein kinase A activity in osteocytes and late osteoblasts produces an anabolic effect on bone. Bone. 2013 Aug; 55(2):277-87. Kao RS, Abbott MJ, Louie A, O'Carroll D, Lu W, Nissenson R. PMID: 23583750.

View in: PubMed Mentions: 7 Fields:
Met Metabolism Ort Orthopedics
Translation:Animals Cells
Cyclic AMP signaling in bone marrow stromal cells has reciprocal effects on the ability of mesenchymal stem cells to differentiate into mature osteoblasts versus mature adipocytes. Endocrine. 2012 Dec; 42(3):622-36. Kao R, Lu W, Louie A, Nissenson R. PMID: 22695986.

View in: PubMed Mentions: 9 Fields:
End Endocrinology
Translation:Animals Cells
Lamellar spacing in cuboid hydroxyapatite scaffolds regulates bone formation by human bone marrow stromal cells. Tissue Eng Part A. 2011 Jun; 17(11-12):1615-23. Mankani MH, Afghani S, Franco J, Launey M, Marshall S, Marshall GW, Nissenson R, Lee J, Tomsia AP, Saiz E. PMID: 21294634.

View in: PubMed Mentions: 5 Fields:
Bio Biotechnology His Histology
Translation:Humans Animals Cells
Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation. J Bone Miner Res. 2011 Apr; 26(4):822-32. Millard SM, Louie AM, Wattanachanya L, Wronski TJ, Conklin BR, Nissenson RA. PMID: 20939063.

View in: PubMed Mentions: 9 Fields:
Met Metabolism Ort Orthopedics
Translation:Animals Cells
Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation. J Bone Miner Res. 2010 Mar; 25(3):584-93. Hsiao EC, Boudignon BM, Halloran BP, Nissenson RA, Conklin BR. PMID: 20200944.

View in: PubMed Mentions: 17 Fields:
Met Metabolism Ort Orthopedics
Translation:Animals Cells
Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation. Mol Endocrinol. 2010 Mar; 24(3):621-31. Hsiao EC, Millard SM, Louie A, Huang Y, Conklin BR, Nissenson RA. PMID: 20150184.

View in: PubMed Mentions: 7 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals Cells
Engineering GPCR signaling pathways with RASSLs. Nat Methods. 2008 Aug; 5(8):673-8. Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. PMID: 18668035.

View in: PubMed Mentions: 106 Fields:
Cli Clinical Laboratory Techniques
Translation:Humans Animals Cells
Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1209-14. Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA. PMID: 18212126.

View in: PubMed Mentions: 54 Fields:
Sci Science
Translation:Humans Animals Cells
Resolution dependence of the non-metric trabecular structure indices. Bone. 2008 Apr; 42(4):728-36. Sode M, Burghardt AJ, Nissenson RA, Majumdar S. PMID: 18276202.

View in: PubMed Mentions: 23 Fields:
Met Metabolism Ort Orthopedics
Translation:Humans Animals
Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. . 2008 Jan; 294(1):H205-12. McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ. PMID: 17965283.

View in: PubMed Mentions:
PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res. 2004 Feb; 19(2):235-44. Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson RA. PMID: 14969393.

View in: PubMed Mentions: 87 Fields:
Met Metabolism Ort Orthopedics
Translation:Animals Cells
Parathyroid hormone receptor recycling: role of receptor dephosphorylation and beta-arrestin. Mol Endocrinol. 2002 Dec; 16(12):2720-32. Chauvin S, Bencsik M, Bambino T, Nissenson RA. PMID: 12456793.

View in: PubMed Mentions: 25 Fields:
End Endocrinology Mol Molecular Biology
Translation:Humans Animals Cells
Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. J Biol Chem. 2002 Mar 08; 277(10):8121-9. Vilardaga JP, Krasel C, Chauvin S, Bambino T, Lohse MJ, Nissenson RA. PMID: 11726668.

View in: PubMed Mentions: 39 Fields:
Bio Biochemistry
Translation:Humans Cells