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Robert Nissenson, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentMedicine
Address4150 Clement St
San Francisco CA 94121
Phone415-575-0553
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    Collapse Biography 
    Collapse Education and Training
    Cornell University, Ithaca, NY06/1969Chemistry
    Northwestern University, Evanston, ILB.A.06/1971Biology
    Northwestern University Medical School, Chicago, ILPh.D.06/1976Physiology
    Mayo Clinic, Rochester, MN06/1977Postdoctoral Research in Endocrinology
    University of California, San Francisco, San Francisco, CA06/1980Postdoctoral Research in Endocrinology

    Collapse Research 
    Collapse Research Activities and Funding
    Inhibitory G protein (Gi) signaling in bone disease and repair
    VA I01BX003212Oct 1, 2016 - Sep 30, 2020
    Role: Principal Investigator
    Mechanisms Underlying Hormonal Regulation of Fracture Repair
    VA IP1BX001599Jan 1, 2012 - Dec 31, 2015
    Role: Co-Principal Investigator
    G Protein Signaling in Osteoblasts
    VA I01BX001496Oct 1, 2011 - Sep 30, 2015
    Role: Principal Investigator
    G PROTEIN SIGNALING IN OSTEOBLASTS
    NIH/NIDDK R01DK072071Feb 1, 2006 - Dec 31, 2011
    Role: Principal Investigator
    G Protein Signaling in Osteoblasts
    NIH/NIDDK R56DK072071Apr 12, 2005 - Sep 30, 2011
    Role: Principal Investigator
    Role of Beta-Catenin Signaling in Osteoblast Function
    NIH/NIAMS R21AR051692Sep 30, 2004 - Jun 30, 2006
    Role: Principal Investigator
    2003 Bones &Teeth Gordon Conference
    NIH/NIAMS R13AR050390Aug 1, 2003 - Jul 31, 2004
    Role: Principal Investigator
    CLONING OF THE PARATHYROID HORMONE RECEPTOR CDNA
    NIH/NIDDK R01DK042146May 1, 1991 - Apr 30, 1995
    Role: Principal Investigator
    PARATHYROID HORMONE RECEPTORS IN KIDNEY AND BONE
    NIH/NIDDK R01DK035323Apr 1, 1985 - Dec 31, 2004
    Role: Principal Investigator
    PARATHYROID HORMONE RECEPTORS IN KIDNEY AND BONE
    NIH/NIADDK R01AM035323Apr 1, 1985 - Mar 31, 1988
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson R. Sirtuin-3 Promotes Adipogenesis, Osteoclastogenesis, and Bone Loss in Aging Male Mice. Endocrinology. 2017 09 01; 158(9):2741-2753. PMID: 28911171.
      View in: PubMed
    2. Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson R. Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice. Endocrinology. 2017 06 01; 158(6):1715-1726. PMID: 28407060.
      View in: PubMed
    3. Wang L, Roth T, Abbott M, Ho L, Wattanachanya L, Nissenson R. Osteoblast-derived FGF9 regulates skeletal homeostasis. Bone. 2017 05; 98:18-25. PMID: 28189801.
      View in: PubMed
    4. Hsiao EC, Millard SM, Nissenson R. Gs/Gi Regulation of Bone Cell Differentiation: Review and Insights from Engineered Receptors. Horm Metab Res. 2016 Nov; 48(11):689-699. PMID: 27643449.
      View in: PubMed
    5. Shoback DM, Heath H, Bikle DD, Chang W, Halloran B, Strewler G, Nissenson R. Claude D Arnaud, Jr, MD (1929-2016): ASBMR Loses a Founding Father. J Bone Miner Res. 2016 Dec; 31(12):2067-2068. PMID: 27566952.
      View in: PubMed
    6. Liu X, Ning AY, Chang NC, Kim H, Nissenson R, Wang L, Feeley BT. Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury. Muscles Ligaments Tendons J. 2016 Jan-Mar; 6(1):6-15. PMID: 27331027.
      View in: PubMed
    7. Shahnazari M, Turner RT, Iwaniec UT, Wronski TJ, Li M, Ferruzzi MG, Nissenson R, Halloran BP. Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice. J Nutr Biochem. 2016 08; 34:73-82. PMID: 27239754.
      View in: PubMed
    8. Abbott MJ, Roth TM, Ho L, Wang L, O'Carroll D, Nissenson R. Negative Skeletal Effects of Locally Produced Adiponectin. PLoS One. 2015; 10(7):e0134290. PMID: 26230337.
      View in: PubMed
    9. Wang L, Carroll DO, Liu X, Roth T, Kim H, Halloran B, Nissenson R. Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification. J Orthop Res. 2015 Aug; 33(8):1212-7. PMID: 25773760.
      View in: PubMed
    10. Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson R. Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing. J Bone Miner Res. 2015 Oct; 30(10):1896-904. PMID: 25917236.
      View in: PubMed
    11. Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao EC, Conklin BR, Nissenson R. Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts. Exp Cell Res. 2015 May 01; 333(2):289-302. PMID: 25704759; PMCID: PMC4408231.
      View in: PubMed, PubMed Central
    12. Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X. Novel mouse model of spinal cord injury-induced heterotopic ossification. J Rehabil Res Dev. 2014; 51(7):1109-18. PMID: 25436890.
      View in: PubMed
    13. Liu X, Kang H, Shahnazari M, Kim H, Wang L, Larm O, Adolfsson L, Nissenson R, Halloran B. A novel mouse model of trauma induced heterotopic ossification. J Orthop Res. 2014 Feb; 32(2):183-8. PMID: 24136593.
      View in: PubMed
    14. Shahnazari M, Chu V, Wronski TJ, Nissenson R, Halloran BP. CXCL12/CXCR4 signaling in the osteoblast regulates the mesenchymal stem cell and osteoclast lineage populations. FASEB J. 2013 Sep; 27(9):3505-13. PMID: 23704087.
      View in: PubMed
    15. Wattanachanya L, Lu WD, Kundu RK, Wang L, Abbott MJ, O'Carroll D, Quertermous T, Nissenson R. Increased bone mass in mice lacking the adipokine apelin. Endocrinology. 2013 Jun; 154(6):2069-80. PMID: 23584856; PMCID: PMC3740482.
      View in: PubMed, PubMed Central
    16. Kao RS, Abbott MJ, Louie A, O'Carroll D, Lu W, Nissenson R. Constitutive protein kinase A activity in osteocytes and late osteoblasts produces an anabolic effect on bone. Bone. 2013 Aug; 55(2):277-87. PMID: 23583750; PMCID: PMC3690773.
      View in: PubMed, PubMed Central
    17. Kao R, Lu W, Louie A, Nissenson R. Cyclic AMP signaling in bone marrow stromal cells has reciprocal effects on the ability of mesenchymal stem cells to differentiate into mature osteoblasts versus mature adipocytes. Endocrine. 2012 Dec; 42(3):622-36. PMID: 22695986; PMCID: PMC3509326.
      View in: PubMed, PubMed Central
    18. Kazakia GJ, Speer D, Shanbhag S, Majumdar S, Conklin BR, Nissenson R, Hsiao EC. Mineral composition is altered by osteoblast expression of an engineered G(s)-coupled receptor. Calcif Tissue Int. 2011 Jul; 89(1):10-20. PMID: 21526395; PMCID: PMC3110278.
      View in: PubMed, PubMed Central
    19. Mankani MH, Afghani S, Franco J, Launey M, Marshall S, Marshall GW, Nissenson R, Lee J, Tomsia AP, Saiz E. Lamellar spacing in cuboid hydroxyapatite scaffolds regulates bone formation by human bone marrow stromal cells. Tissue Eng Part A. 2011 Jun; 17(11-12):1615-23. PMID: 21294634; PMCID: PMC3098957.
      View in: PubMed, PubMed Central
    20. Millard SM, Louie AM, Wattanachanya L, Wronski TJ, Conklin BR, Nissenson R. Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation. J Bone Miner Res. 2011 Apr; 26(4):822-32. PMID: 20939063; PMCID: PMC3179326.
      View in: PubMed, PubMed Central
    21. Hsiao EC, Boudignon BM, Halloran BP, Nissenson R, Conklin BR. Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation. J Bone Miner Res. 2010 Mar; 25(3):584-93. PMID: 20200944; PMCID: PMC3153396.
      View in: PubMed, PubMed Central
    22. Hsiao EC, Millard SM, Louie A, Huang Y, Conklin BR, Nissenson R. Ligand-mediated activation of an engineered gs g protein-coupled receptor in osteoblasts increases trabecular bone formation. Mol Endocrinol. 2010 Mar; 24(3):621-31. PMID: 20150184; PMCID: PMC2840804.
      View in: PubMed, PubMed Central
    23. Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson R, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs. Nat Methods. 2008 Aug; 5(8):673-8. PMID: 18668035; PMCID: PMC2703467.
      View in: PubMed, PubMed Central
    24. Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson R. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A. 2008 Jan 29; 105(4):1209-14. PMID: 18212126; PMCID: PMC2234117.
      View in: PubMed, PubMed Central
    25. Sode M, Burghardt AJ, Nissenson R, Majumdar S. Resolution dependence of the non-metric trabecular structure indices. Bone. 2008 Apr; 42(4):728-36. PMID: 18276202; PMCID: PMC2329672.
      View in: PubMed, PubMed Central
    26. Peng J, Bencsik M, Louie A, Lu W, Millard S, Nguyen P, Burghardt A, Majumdar S, Wronski TJ, Halloran B, Conklin BR, Nissenson R. Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinology. 2008 Mar; 149(3):1329-37. PMID: 18048501; PMCID: PMC2275363.
      View in: PubMed, PubMed Central
    27. McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson R, Karliner JS, Baker AJ. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H205-12. PMID: 17965283; PMCID: PMC3372085.
      View in: PubMed, PubMed Central
    28. Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson R. PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res. 2004 Feb; 19(2):235-44. PMID: 14969393.
      View in: PubMed
    29. Chauvin S, Bencsik M, Bambino T, Nissenson R. Parathyroid hormone receptor recycling: role of receptor dephosphorylation and beta-arrestin. Mol Endocrinol. 2002 Dec; 16(12):2720-32. PMID: 12456793.
      View in: PubMed
    30. Vilardaga JP, Krasel C, Chauvin S, Bambino T, Lohse MJ, Nissenson R. Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. J Biol Chem. 2002 Mar 08; 277(10):8121-9. PMID: 11726668.
      View in: PubMed
    31. Vilardaga JP, Lin I, Nissenson R. Analysis of parathyroid hormone (PTH)/secretin receptor chimeras differentiates the role of functional domains in the pth/ pth-related peptide (PTHrP) receptor on hormone binding and receptor activation. Mol Endocrinol. 2001 Jul; 15(7):1186-99. PMID: 11435617.
      View in: PubMed
    32. Vilardaga JP, Frank M, Krasel C, Dees C, Nissenson R, Lohse MJ. Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein. J Biol Chem. 2001 Sep 07; 276(36):33435-43. PMID: 11387315.
      View in: PubMed
    33. Gabarin N, Gavish H, Muhlrad A, Chen YC, Namdar-Attar M, Nissenson R, Chorev M, Bab I. Mitogenic G(i) protein-MAP kinase signaling cascade in MC3T3-E1 osteogenic cells: activation by C-terminal pentapeptide of osteogenic growth peptide [OGP(10-14)] and attenuation of activation by cAMP. J Cell Biochem. 2001; 81(4):594-603. PMID: 11329614.
      View in: PubMed
    34. Nissenson R. Parathyroid hormone-related protein. Rev Endocr Metab Disord. 2000 Nov; 1(4):343-52. PMID: 11706748.
      View in: PubMed
    35. Turner PR, Mefford S, Christakos S, Nissenson R. Apoptosis mediated by activation of the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein (PTHrP). Mol Endocrinol. 2000 Feb; 14(2):241-54. PMID: 10674397.
      View in: PubMed
    36. Sheikh SP, Vilardarga JP, Baranski TJ, Lichtarge O, Iiri T, Meng EC, Nissenson R, Bourne HR. Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. J Biol Chem. 1999 Jun 11; 274(24):17033-41. PMID: 10358054.
      View in: PubMed
    37. Huang Z, Bambino T, Chen Y, Lameh J, Nissenson R. Role of signal transduction in internalization of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein. Endocrinology. 1999 Mar; 140(3):1294-300. PMID: 10067856.
      View in: PubMed
    38. Malecz N, Bambino T, Bencsik M, Nissenson R. Identification of phosphorylation sites in the G protein-coupled receptor for parathyroid hormone. Receptor phosphorylation is not required for agonist-induced internalization. Mol Endocrinol. 1998 Dec; 12(12):1846-56. PMID: 9849959.
      View in: PubMed
    39. Nissenson R. Parathyroid hormone (PTH)/PTHrP receptor mutations in human chondrodysplasia. Endocrinology. 1998 Dec; 139(12):4753-5. PMID: 9832410.
      View in: PubMed
    40. Turner PR, Mefford S, Bambino T, Nissenson R. Transmembrane residues together with the amino terminus limit the response of the parathyroid hormone (PTH) 2 receptor to PTH-related peptide. J Biol Chem. 1998 Feb 13; 273(7):3830-7. PMID: 9461563.
      View in: PubMed
    41. Schipani E, Jensen GS, Pincus J, Nissenson R, Gardella TJ, Jüppner H. Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia. Mol Endocrinol. 1997 Jun; 11(7):851-8. PMID: 9178745.
      View in: PubMed
    42. Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Nissenson R, Shoback DM. The N-terminal region of the third intracellular loop of the parathyroid hormone (PTH)/PTH-related peptide receptor is critical for coupling to cAMP and inositol phosphate/Ca2+ signal transduction pathways. J Biol Chem. 1996 Dec 27; 271(52):33382-9. PMID: 8969199.
      View in: PubMed
    43. Lee K, Lanske B, Karaplis AC, Deeds JD, Kohno H, Nissenson R, Kronenberg HM, Segre GV. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology. 1996 Nov; 137(11):5109-18. PMID: 8895385.
      View in: PubMed
    44. Jobert AS, Fernandes I, Turner G, Coureau C, Prie D, Nissenson R, Friedlander G, Silve C. Expression of alternatively spliced isoforms of the parathyroid hormone (PTH)/PTH-related peptide receptor messenger RNA in human kidney and bone cells. Mol Endocrinol. 1996 Sep; 10(9):1066-76. PMID: 8885241.
      View in: PubMed
    45. Blind E, Bambino T, Huang Z, Bliziotes M, Nissenson R. Phosphorylation of the cytoplasmic tail of the PTH/PTHrP receptor. J Bone Miner Res. 1996 May; 11(5):578-86. PMID: 9157772.
      View in: PubMed
    46. Lane NE, Kimmel DB, Nilsson MH, Cohen FE, Newton S, Nissenson R, Strewler GJ. Bone-selective analogs of human PTH(1-34) increase bone formation in an ovariectomized rat model. J Bone Miner Res. 1996 May; 11(5):614-25. PMID: 9157776.
      View in: PubMed
    47. Turner PR, Bambino T, Nissenson R. A putative selectivity filter in the G-protein-coupled receptors for parathyroid hormone and secretion. J Biol Chem. 1996 Apr 19; 271(16):9205-8. PMID: 8621578.
      View in: PubMed
    48. Turner PR, Bambino T, Nissenson R. Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor. Mol Endocrinol. 1996 Feb; 10(2):132-9. PMID: 8825553.
      View in: PubMed
    49. Blind E, Bambino T, Nissenson R. Agonist-stimulated phosphorylation of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein. Endocrinology. 1995 Oct; 136(10):4271-7. PMID: 7664644.
      View in: PubMed
    50. Huang Z, Chen Y, Pratt S, Chen TH, Bambino T, Shoback DM, Nissenson R. Mutational analysis of the cytoplasmic tail of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein: effects on receptor expression and signaling. Mol Endocrinol. 1995 Sep; 9(9):1240-9. PMID: 7491116.
      View in: PubMed
    51. Funk JL, Lausier J, Moser AH, Shigenaga JK, Huling S, Nissenson R, Strewler GJ, Grunfeld C, Feingold KR. Endotoxin induces parathyroid hormone-related protein gene expression in splenic stromal and smooth muscle cells, not in splenic lymphocytes. Endocrinology. 1995 Aug; 136(8):3412-21. PMID: 7628377.
      View in: PubMed
    52. Huang Z, Chen Y, Nissenson R. The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis. J Biol Chem. 1995 Jan 06; 270(1):151-6. PMID: 7814366.
      View in: PubMed
    53. Schermer DT, Bradley MS, Bambino TH, Nissenson R, Strewler GJ. Functional properties of a synthetic chicken parathyroid hormone-related protein 1-36 fragment. J Bone Miner Res. 1994 Jul; 9(7):1041-6. PMID: 7942150.
      View in: PubMed
    54. Strewler GJ, Budayr AA, Clark OH, Nissenson R. Production of parathyroid hormone by a malignant nonparathyroid tumor in a hypercalcemic patient. J Clin Endocrinol Metab. 1993 May; 76(5):1373-5. PMID: 7684395.
      View in: PubMed
    55. Nissenson R, Huang Z, Blind E, Shoback D. Structure and function of the receptor for parathyroid hormone and parathyroid hormone-related protein. Receptor. 1993; 3(3):193-202. PMID: 8167570.
      View in: PubMed
    56. Strewler GJ, Chan SD, Globus RK, Schermer DT, Nissenson R. Actions of parathyroid hormone-related protein as an embryonic differentiation factor. J Endocrinol Invest. 1992; 15(9 Suppl 6):57-62. PMID: 1300340.
      View in: PubMed
    57. Klein RF, Nissenson R, Strewler GJ. Pertussis toxin inhibits hormonal stimulation of bone resorption in fetal rat limb bones. J Pharmacol Exp Ther. 1991 Sep; 258(3):877-81. PMID: 1653845.
      View in: PubMed
    58. Babich M, Choi H, Johnson RM, King KL, Alford GE, Nissenson R. Thrombin and parathyroid hormone mobilize intracellular calcium in rat osteosarcoma cells by distinct pathways. Endocrinology. 1991 Sep; 129(3):1463-70. PMID: 1874183.
      View in: PubMed
    59. Karpf DB, Bambino T, Alford G, Nissenson R. Features of the renal parathyroid hormone-parathyroid hormone-related protein receptor derived from structural studies of receptor fragments. J Bone Miner Res. 1991 Feb; 6(2):173-82. PMID: 1851372.
      View in: PubMed
    60. Schermer DT, Chan SD, Bruce R, Nissenson R, Wood WI, Strewler GJ. Chicken parathyroid hormone-related protein and its expression during embryologic development. J Bone Miner Res. 1991 Feb; 6(2):149-55. PMID: 1709333.
      View in: PubMed
    61. Cohen FE, Strewler GJ, Bradley MS, Carlquist M, Nilsson M, Ericsson M, Ciardelli TL, Nissenson R. Analogues of parathyroid hormone modified at positions 3 and 6. Effects on receptor binding and activation of adenylyl cyclase in kidney and bone. J Biol Chem. 1991 Jan 25; 266(3):1997-2004. PMID: 1846369.
      View in: PubMed
    62. Pun KK, Ho PW, Nissenson R, Arnaud CD. Desensitization of parathyroid hormone receptors on cultured bone cells. J Bone Miner Res. 1990 Dec; 5(12):1193-200. PMID: 1963732.
      View in: PubMed
    63. Strewler GJ, Nissenson R. Hypercalcemia in malignancy. West J Med. 1990 Dec; 153(6):635-40. PMID: 2293469; PMCID: PMC1002641.
      View in: PubMed, PubMed Central
    64. Chan SD, Strewler GJ, Nissenson R. Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells. J Biol Chem. 1990 Nov 25; 265(33):20081-4. PMID: 2122968.
      View in: PubMed
    65. Chan SD, Strewler GJ, King KL, Nissenson R. Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells. Mol Endocrinol. 1990 Apr; 4(4):638-46. PMID: 2177844.
      View in: PubMed
    66. Babich M, King KL, Nissenson R. Thrombin stimulates inositol phosphate production and intracellular free calcium by a pertussis toxin-insensitive mechanism in osteosarcoma cells. Endocrinology. 1990 Feb; 126(2):948-54. PMID: 2153536.
      View in: PubMed
    67. Strewler GJ, Nissenson R. Peptide mediators of hypercalcemia in malignancy. Annu Rev Med. 1990; 41:35-44. PMID: 2184736.
      View in: PubMed
    68. Budayr AA, Nissenson R, Klein RF, Pun KK, Clark OH, Diep D, Arnaud CD, Strewler GJ. Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia. Ann Intern Med. 1989 Nov 15; 111(10):807-12. PMID: 2817628.
      View in: PubMed
    69. Budayr AA, Halloran BP, King JC, Diep D, Nissenson R, Strewler GJ. High levels of a parathyroid hormone-like protein in milk. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):7183-5. PMID: 2550932; PMCID: PMC298020.
      View in: PubMed, PubMed Central
    70. Babich M, King KL, Nissenson R. G protein-dependent activation of a phosphoinositide-specific phospholipase C in UMR-106 osteosarcoma cell membranes. J Bone Miner Res. 1989 Aug; 4(4):549-56. PMID: 2554686.
      View in: PubMed
    71. Karpf DB, Arnaud CD, Bambino T, Duffy D, King KL, Winer J, Nissenson R. Structural properties of the renal parathyroid hormone receptor: hydrodynamic analysis and protease sensitivity. Endocrinology. 1988 Dec; 123(6):2611-20. PMID: 2848681.
      View in: PubMed
    72. Nissenson R, Diep D, Strewler GJ. Synthetic peptides comprising the amino-terminal sequence of a parathyroid hormone-like protein from human malignancies. Binding to parathyroid hormone receptors and activation of adenylate cyclase in bone cells and kidney. J Biol Chem. 1988 Sep 15; 263(26):12866-71. PMID: 2843501.
      View in: PubMed
    73. Pun KK, Arnaud CD, Nissenson R. Parathyroid hormone receptors in human dermal fibroblasts: structural and functional characterization. J Bone Miner Res. 1988 Aug; 3(4):453-60. PMID: 2851922.
      View in: PubMed
    74. Thiede MA, Strewler GJ, Nissenson R, Rosenblatt M, Rodan GA. Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single-copy gene. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4605-9. PMID: 3290897; PMCID: PMC280483.
      View in: PubMed, PubMed Central
    75. Klein RF, Nissenson R, Strewler GJ. Forskolin mimics the effects of calcitonin but not parathyroid hormone on bone resorption in vitro. Bone Miner. 1988 Jul; 4(3):247-56. PMID: 2847839.
      View in: PubMed
    76. Karpf DB, Arnaud CD, King K, Bambino T, Winer J, Nyiredy K, Nissenson R. The canine renal parathyroid hormone receptor is a glycoprotein: characterization and partial purification. Biochemistry. 1987 Dec 01; 26(24):7825-33. PMID: 2827760.
      View in: PubMed
    77. Strewler GJ, Stern PH, Jacobs JW, Eveloff J, Klein RF, Leung SC, Rosenblatt M, Nissenson R. Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. J Clin Invest. 1987 Dec; 80(6):1803-7. PMID: 3680530; PMCID: PMC442457.
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    78. Forero MS, Klein RF, Nissenson R, Nelson K, Heath H, Arnaud CD, Riggs BL. Effect of age on circulating immunoreactive and bioactive parathyroid hormone levels in women. J Bone Miner Res. 1987 Oct; 2(5):363-6. PMID: 3455620.
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    79. Nissenson R, Karpf D, Bambino T, Winer J, Canga M, Nyiredy K, Arnaud CD. Covalent labeling of a high-affinity, guanyl nucleotide sensitive parathyroid hormone receptor in canine renal cortex. Biochemistry. 1987 Apr 07; 26(7):1874-8. PMID: 3036211.
      View in: PubMed
    80. Klein RF, Strewler GJ, Leung SC, Nissenson R. Parathyroid hormone-like adenylate cyclase-stimulating activity from a human carcinoma is associated with bone-resorbing activity. Endocrinology. 1987 Feb; 120(2):504-11. PMID: 3026777.
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    81. Strewler GJ, Nissenson R. Nonparathyroid hypercalcemia. Adv Intern Med. 1987; 32:235-58. PMID: 3030065.
      View in: PubMed
    82. Strewler GJ, Wronski TJ, Halloran BP, Miller SC, Leung SC, Williams RD, Nissenson R. Pathogenesis of hypercalcemia in nude mice bearing a human renal carcinoma. Endocrinology. 1986 Jul; 119(1):303-10. PMID: 3013591.
      View in: PubMed
    83. Nissenson R, Mann E, Winer J, Teitelbaum AP, Arnaud CD. Solubilization of a guanine nucleotide-sensitive parathyroid hormone-receptor complex from canine renal cortex. Endocrinology. 1986 Mar; 118(3):932-9. PMID: 3004900.
      View in: PubMed
    84. Nissenson R, Mann E, Winer J, Teitelbaum A, Arnaud CD. Solubilization of a guanine nucleotide-sensitive parathyroid hormone-receptor complex from canine renal cortex. Adv Exp Med Biol. 1986; 208:329-43. PMID: 3031942.
      View in: PubMed
    85. Calvo MS, Fryer MJ, Laakso KJ, Nissenson R, Price PA, Murray TM, Heath H. Structural requirements for parathyroid hormone action in mature bone. Effects on release of cyclic adenosine monophosphate and bone gamma-carboxyglutamic acid-containing protein from perfused rat hindquarters. J Clin Invest. 1985 Dec; 76(6):2348-54. PMID: 3001148; PMCID: PMC424371.
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