Robert Seed, PhD

Title(s)Associate Researcher, Pathology
SchoolSchool of Medicine
Address513 Parnassus Avenue, HSW, #425
San Francisco CA 94143
Phone628-206-3676
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    University of York, York (UK)09/2017Postdoc in prostate cancer aetiology
    UCSF Dept. of Pathology, San Francisco05/2014Postdoc in pulmonary fibrosis
    University of Birmingham, Birmingham (UK)PhD01/2013Experimental medicine
    University of Lancaster, Lancaster (UK)MSc09/2008Biomedicine
    University of Leeds, Leeds (UK)BSc07/2007Biochemistry

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Latent-TGF-β has a domain swapped architecture. Res Sq. 2024 Nov 01. Nishimura S, Jin M, Seed R, Shing T, Cheng Y. PMID: 39574885; PMCID: PMC11581116.
      View in: PubMed   Mentions:
    2. Dynamic allostery drives autocrine and paracrine TGF-β signaling. Cell. 2024 Oct 31; 187(22):6200-6219.e23. Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y. PMID: 39288764; PMCID: PMC11531391.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    3. Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury. Front Immunol. 2022; 13:880887. Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M. PMID: 35634278; PMCID: PMC9134074.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    4. Measurement of Cell Intrinsic TGF-β Activation Mediated by the Integrin αvβ8. Bio Protoc. 2022 Apr 20; 12(8):e4385. Seed RI, Nishimura SL. PMID: 35800099; PMCID: PMC9081475.
      View in: PubMed   Mentions:
    5. Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria. Elife. 2022 04 06; 11. Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT. PMID: 35384838; PMCID: PMC9183236.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    6. A Systematic Comparison of Antiandrogens Identifies Androgen Receptor Protein Stability as an Indicator for Treatment Response. Life (Basel). 2021 Aug 25; 11(9). Siciliano T, Simons IH, Beier AK, Ebersbach C, Aksoy C, Seed RI, Stope MB, Thomas C, Erb HHH. PMID: 34575023; PMCID: PMC8468615.
      View in: PubMed   Mentions: 9  
    7. A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8. Sci Immunol. 2021 03 26; 6(57). Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL. PMID: 33771888; PMCID: PMC8425767.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    8. Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β. Cell. 2020 02 06; 180(3):490-501.e16. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL. PMID: 31955848; PMCID: PMC7238552.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    9. PIAS1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target. PLoS One. 2019; 14(10):e0224085. Erb HHH, Ebert M, Kuhn R, Donix L, Haferkamp A, Seed RI, Jüngel E. PMID: 31639157; PMCID: PMC6804980.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. The putative tumour suppressor protein Latexin is secreted by prostate luminal cells and is downregulated in malignancy. Sci Rep. 2019 03 26; 9(1):5120. Seed RI, Taurozzi AJ, Wilcock DJ, Nappo G, Erb HHH, Read ML, Gurney M, Archer LK, Ito S, Rumsby MG, Petrie JL, Clayton A, Maitland NJ, Collins AT. PMID: 30914656; PMCID: PMC6435711.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    11. Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells. JCI Insight. 2018 10 18; 3(20). Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL. PMID: 30333313; PMCID: PMC6237456.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    12. Spontaneous development of Epstein-Barr Virus associated human lymphomas in a prostate cancer xenograft program. PLoS One. 2017; 12(11):e0188228. Taurozzi AJ, Beekharry R, Wantoch M, Labarthe MC, Walker HF, Seed RI, Simms M, Rodrigues G, Bradford J, van der Horst G, van der Pluijm G, Collins AT. PMID: 29145505; PMCID: PMC5690647.
      View in: PubMed   Mentions: 15     Fields:    
    13. The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling. Oncogenesis. 2017 May 29; 6(5):e342. Nappo G, Handle F, Santer FR, McNeill RV, Seed RI, Collins AT, Morrone G, Culig Z, Maitland NJ, Erb HHH. PMID: 28553931; PMCID: PMC5523058.
      View in: PubMed   Mentions: 50  
    14. The proto-oncogene PBF binds p53 and is associated with prognostic features in colorectal cancer. Mol Carcinog. 2016 Jan; 55(1):15-26. Read ML, Seed RI, Modasia B, Kwan PP, Sharma N, Smith VE, Watkins RJ, Bansal S, Gagliano T, Stratford AL, Ismail T, Wakelam MJ, Kim DS, Ward ST, Boelaert K, Franklyn JA, Turnell AS, McCabe CJ. PMID: 25408419.
      View in: PubMed   Mentions: 11     Fields:    
    15. Selective targeting of TGF-β activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. PMID: 24944194; PMCID: PMC4341974.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    16. The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells. Endocrinology. 2014 Apr; 155(4):1222-34. Read ML, Seed RI, Fong JC, Modasia B, Ryan GA, Watkins RJ, Gagliano T, Smith VE, Stratford AL, Kwan PK, Sharma N, Dixon OM, Watkinson JC, Boelaert K, Franklyn JA, Turnell AS, McCabe CJ. PMID: 24506068; PMCID: PMC4759943.
      View in: PubMed   Mentions: 19     Fields:    
    17. Regulation of pituitary tumor transforming gene (PTTG) expression and phosphorylation in thyroid cells. Endocrinology. 2013 Nov; 154(11):4408-22. Lewy GD, Ryan GA, Read ML, Fong JC, Poole V, Seed RI, Sharma N, Smith VE, Kwan PP, Stewart SL, Bacon A, Warfield A, Franklyn JA, McCabe CJ, Boelaert K. PMID: 23867215.
      View in: PubMed   Mentions: 5     Fields:    
    18. PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8. Endocrinology. 2012 Jul; 153(7):3526-36. Smith VE, Read ML, Turnell AS, Sharma N, Lewy GD, Fong JC, Seed RI, Kwan P, Ryan G, Mehanna H, Chan SY, Darras VM, Boelaert K, Franklyn JA, McCabe CJ. PMID: 22535767.
      View in: PubMed   Mentions: 5     Fields:    
    19. The pituitary tumor transforming gene in thyroid cancer. J Endocrinol Invest. 2012 Apr; 35(4):425-33. Lewy GD, Sharma N, Seed RI, Smith VE, Boelaert K, McCabe CJ. PMID: 22522436.
      View in: PubMed   Mentions: 4     Fields:    
    20. Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection. J Virol. 2012 Mar; 86(6):3167-79. Forrester NA, Patel RN, Speiseder T, Groitl P, Sedgwick GG, Shimwell NJ, Seed RI, Catnaigh PÓ, McCabe CJ, Stewart GS, Dobner T, Grand RJ, Martin A, Turnell AS. PMID: 22205733; PMCID: PMC3302322.
      View in: PubMed   Mentions: 21     Fields:    
    21. Proto-oncogene PBF/PTTG1IP regulates thyroid cell growth and represses radioiodide treatment. Cancer Res. 2011 Oct 01; 71(19):6153-64. Read ML, Lewy GD, Fong JC, Sharma N, Seed RI, Smith VE, Gentilin E, Warfield A, Eggo MC, Knauf JA, Leadbeater WE, Watkinson JC, Franklyn JA, Boelaert K, McCabe CJ. PMID: 21844185; PMCID: PMC3184940.
      View in: PubMed   Mentions: 16     Fields:    
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