Joshua Robinson, PhD
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Title(s) | Assistant Professor, Ob/Gyn, Reproductive Sciences |
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School | School of Medicine |
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Address | 35 Medical Center Way San Francisco CA 94143
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Phone | 415-476-1573 |
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ORCID
.gif) | 0000-0002-2421-4535  |
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vCard | Download vCard |
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Biography University of California, San Francisco, CA | Postdoctoral | 2016 | Human Biology | National Institute for Public Health and the Environment (RIVM), Bilthoven, NL | Postdoctoral | 2012 | Bioinformatics | University of Washington, Seattle, WA | PhD | 2008 | Developmental Toxicology | University of Washington, Seattle, WA | MS | 2005 | Developmental Toxicology |
Teratology Society | 2011 | | Marie Taubeneck Award | Society of Toxicology | 2013 | | Best Paper in Toxicological Sciences (Repro/Dev) | NIH/NIEHS | 2014
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| 2018 | K99/R00 Pathway to Independence Award | European Teratology Society | 2017 | | Elsevier Award, Best Paper in Reproductive Toxicology | Society of Toxicology | 2018 | | Angelo Furgiele Young Investigator Technology Award | Hellman Foundation | 2019 | | Hellman Award for Early-Career Faculty | Society of Birth Defects Research and Prevention | 2020 | | F. Clarke Fraser Early Investigator Award |
Overview During human pregnancy, the embryo/fetus is exposed to thousands of unique environmental chemicals with unknown consequences. My research aims to determine the potential effects of these compounds and to identify the mechanistic links between environmental exposures in utero and adverse developmental outcomes (e.g., neurodevelopmental disorders, neural tube defects, placental diseases). To study these relationships, we employ three model systems: human embryonic stem cells, rodent whole embryo culture, and primary human trophoblasts. We combine classical molecular, genomic, morphological/imaging, and in silico based approaches to conduct in-depth chemical assessments and to determine modes of action. Our current investigations are focused on evaluating the effects of polybrominated diphenyl ethers (PBDEs)—commonly used flame retardants—and their alternatives on human pregnancy (in vitro). Additional research projects in the lab include: 1) establishing alternative model systems for developmental toxicology; 2) identifying human biomarkers of response; 3) developing strategies to integrate diverse toxicogenomic data; and 4) characterizing age-dependent differences in human xenobiotic metabolism. We anticipate that this research—which coalesces elements of developmental toxicology, genomics, and risk assessment—will lead to the discovery of gene-environment interactions underlying toxicity, and future prevention of specific chemical exposures that occur during human pregnancy.
Research ORNG Applications Bibliographic
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Cytotrophoblast extracellular vesicles enhance decidual cell secretion of immune modulators via TNFa. Development. 2020 Sep 08; 147(17).
PMID: 32747437.
View in: PubMed Mentions: Fields:
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Differences in cytochrome p450 enzyme expression and activity in fetal and adult tissues. Placenta. 2020 10; 100:35-44.
Robinson JF, Hamilton EG, Lam J, Chen H, Woodruff TJ. PMID: 32818874.
View in: PubMed Mentions: Fields:
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Racial/ethnic and geographic differences in polybrominated diphenyl ether (PBDE) levels across maternal, placental, and fetal tissues during mid-gestation. Sci Rep. 2020 07 22; 10(1):12247.
Varshavsky JR, Sen S, Robinson JF, Smith SC, Frankenfield J, Wang Y, Yeh G, Park JS, Fisher SJ, Woodruff TJ. PMID: 32699379.
View in: PubMed Mentions: 1 Fields: Translation: HumansPHPublic Health
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Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15852-15861.
McNally L, Zhou Y, Robinson JF, Zhao G, Chen LM, Chen H, Kim MY, Kapidzic M, Gormley M, Hannibal R, Fisher SJ. PMID: 32576693.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Retinoids and developmental neurotoxicity: Utilizing toxicogenomics to enhance adverse outcome pathways and testing strategies. Reprod Toxicol. 2020 Jun 13; 96:102-113.
Chen H, Chidboy MA, Robinson JF. PMID: 32544423.
View in: PubMed Mentions: Fields:
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Association of polybrominated diphenyl ether (PBDE) levels with biomarkers of placental development and disease during mid-gestation. Environ Health. 2020 06 03; 19(1):61.
Varshavsky JR, Robinson JF, Zhou Y, Puckett KA, Kwan E, Buarpung S, Aburajab R, Gaw SL, Sen S, Smith SC, Frankenfield J, Park JS, Fisher SJ, Woodruff TJ. PMID: 32493340.
View in: PubMed Mentions: Fields: Translation: HumansPHPublic Health
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Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface. Reprod Sci. 2020 01; 27(1):100-109.
Leon-Martinez D, Robinson JF, Zdravkovic T, Genbacev O, Gormley M, Mcmaster M, Fisher SJ, Bianco K. PMID: 32046398.
View in: PubMed Mentions: Fields: Translation: HumansCells
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Circulating Monocytes, Tissue Macrophages, and Malaria. J Trop Med. 2019; 2019:3720838.
Ozarslan N, Robinson JF, Gaw SL. PMID: 31662766.
View in: PubMed Mentions:
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Using a Multi-Stage hESC Model to Characterize BDE-47 Toxicity during Neurogenesis. Toxicol Sci. 2019 Jun 07.
Chen H, Seifikar H, Larocque N, Kim Y, Khatib I, Fernandez CJ, Abello N, Robinson JF. PMID: 31173147.
View in: PubMed Mentions: 2 Fields:
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Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts. Toxicol Sci. 2019 01 01; 167(1):211-226.
Robinson JF, Kapidzic M, Hamilton EG, Chen H, Puckett KW, Zhou Y, Ona K, Parry E, Wang Y, Park JS, Costello JF, Fisher SJ. PMID: 30202865.
View in: PubMed Mentions: 5 Fields: Translation: HumansCells
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Convergence of placenta biology and genetic risk for schizophrenia. Nat Med. 2018 06; 24(6):792-801.
Ursini G, Punzi G, Chen Q, Marenco S, Robinson JF, Porcelli A, Hamilton EG, Mitjans M, Maddalena G, Begemann M, Seidel J, Yanamori H, Jaffe AE, Berman KF, Egan MF, Straub RE, Colantuoni C, Blasi G, Hashimoto R, Rujescu D, Ehrenreich H, Bertolino A, Weinberger DR. PMID: 29808008.
View in: PubMed Mentions: 28 Fields: Translation: Humans
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Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs) in maternal and fetal tissues, and associations with fetal cytochrome P450 gene expression. Environ Int. 2018 03; 112:269-278.
PMID: 29316516.
View in: PubMed Mentions: 6 Fields: Translation: HumansCellsPHPublic Health
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Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts. Endocrinology. 2017 06 01; 158(6):1581-1594.
PMID: 28323933.
View in: PubMed Mentions: 6 Fields: Translation: HumansCells
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A genomics-based framework for identifying biomarkers of human neurodevelopmental toxicity. Reprod Toxicol. 2016 04; 60:1-10.
PMID: 26827931.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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Rbpj links uterine transformation and embryo orientation. Cell Res. 2014 Sep; 24(9):1031-2.
PMID: 25145360.
View in: PubMed Mentions: Fields: Translation: HumansAnimals
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Valproic acid-induced gene expression responses in rat whole embryo culture and comparison across in vitro developmental and non-developmental models. Reprod Toxicol. 2013 Nov; 41:57-66.
PMID: 23811354.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Toxicogenomic approaches in developmental toxicology testing. Methods Mol Biol. 2013; 947:451-73.
PMID: 23138921.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimals
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Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests. Toxicol Sci. 2013 Mar; 132(1):118-30.
PMID: 23243006.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Dose-response analysis of phthalate effects on gene expression in rat whole embryo culture. Toxicol Appl Pharmacol. 2012 Oct 01; 264(1):32-41.
PMID: 22841773.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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Dose response analysis of monophthalates in the murine embryonic stem cell test assessed by cardiomyocyte differentiation and gene expression. Reprod Toxicol. 2013 Jan; 35:81-8.
PMID: 22813628.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Triazole induced concentration-related gene signatures in rat whole embryo culture. Reprod Toxicol. 2012 Sep; 34(2):275-83.
PMID: 22664269.
View in: PubMed Mentions: 3 Fields: Translation: Animals
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Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn). Toxicol Appl Pharmacol. 2012 Aug 01; 262(3):330-40.
PMID: 22634333.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
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Transcriptomic analysis of neurulation and early organogenesis in rat embryos: an in vivo and ex vivo comparison. Toxicol Sci. 2012 Mar; 126(1):255-66.
PMID: 22262562.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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A comparison of gene expression responses in rat whole embryo culture and in vivo: time-dependent retinoic acid-induced teratogenic response. Toxicol Sci. 2012 Mar; 126(1):242-54.
PMID: 22262565.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsPHPublic Health
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A review of toxicogenomic approaches in developmental toxicology. Methods Mol Biol. 2012; 889:347-71.
PMID: 22669676.
View in: PubMed Mentions: 5 Fields: Translation: HumansAnimals
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Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn). Toxicol Sci. 2012 Feb; 125(2):430-8.
Theunissen PT, Robinson JF, Pennings JL, de Jong E, Claessen SM, Kleinjans JC, Piersma AH. PMID: 22045034.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Comparison of MeHg-induced toxicogenomic responses across in vivo and in vitro models used in developmental toxicology. Reprod Toxicol. 2011 Sep; 32(2):180-8.
PMID: 21664453.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
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Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells. Toxicol Sci. 2011 Aug; 122(2):437-47.
PMID: 21613230.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Gene set assembly for quantitative prediction of developmental toxicity in the embryonic stem cell test. Toxicology. 2011 Jun 18; 284(1-3):63-71.
PMID: 21473898.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells. Toxicol Sci. 2011 Apr; 120(2):403-12.
Yu X, Sidhu JS, Hong S, Robinson JF, Ponce RA, Faustman EM. PMID: 21252392.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
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Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test. Toxicol Lett. 2011 Mar 05; 201(2):143-51.
van Dartel DA, Pennings JL, Robinson JF, Kleinjans JC, Piersma AH. PMID: 21195148.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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Integrating genetic and toxicogenomic information for determining underlying susceptibility to developmental disorders. Birth Defects Res A Clin Mol Teratol. 2010 Oct; 88(10):920-30.
Robinson JF, Port JA, Yu X, Faustman EM. PMID: 20706997.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsPHPublic Health
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Arsenic- and cadmium-induced toxicogenomic response in mouse embryos undergoing neurulation. Toxicol Appl Pharmacol. 2011 Jan 15; 250(2):117-29.
Robinson JF, Yu X, Moreira EG, Hong S, Faustman EM. PMID: 20883709.
View in: PubMed Mentions: 10 Fields: Translation: Animals
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Embryotoxicant-specific transcriptomic responses in rat postimplantation whole-embryo culture. Toxicol Sci. 2010 Dec; 118(2):675-85.
Robinson JF, van Beelen VA, Verhoef A, Renkens MF, Luijten M, van Herwijnen MH, Westerman A, Pennings JL, Piersma AH. PMID: 20864626.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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A systems-based approach to investigate dose- and time-dependent methylmercury-induced gene expression response in C57BL/6 mouse embryos undergoing neurulation. Birth Defects Res B Dev Reprod Toxicol. 2010 Jun; 89(3):188-200.
Robinson JF, Guerrette Z, Yu X, Hong S, Faustman EM. PMID: 20540155.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
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Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure. Reprod Toxicol. 2010 Sep; 30(2):284-91.
Robinson JF, Griffith WC, Yu X, Hong S, Kim E, Faustman EM. PMID: 20493249.
View in: PubMed Mentions: 5 Fields: Translation: Animals
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Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos. Toxicol Appl Pharmacol. 2010 Jun 15; 245(3):310-25.
Moreira EG, Yu X, Robinson JF, Griffith W, Hong SW, Beyer RP, Bammler TK, Faustman EM. PMID: 20350560.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCellsPHPublic Health
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A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast. Toxicol Sci. 2010 Apr; 114(2):356-77.
Yu X, Robinson JF, Sidhu JS, Hong S, Faustman EM. PMID: 20061341.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Embryonic toxicokinetic and dynamic differences underlying strain sensitivity to cadmium during neurulation. Reprod Toxicol. 2010 Jun; 29(3):279-85.
Robinson JF, Yu X, Hong S, Zhou C, Kim N, DeMasi D, Faustman EM. PMID: 20025959.
View in: PubMed Mentions: 3 Fields: Translation: Animals
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Cadmium-induced differential toxicogenomic response in resistant and sensitive mouse strains undergoing neurulation. Toxicol Sci. 2009 Jan; 107(1):206-19.
Robinson JF, Yu X, Hong S, Griffith WC, Beyer R, Kim E, Faustman EM. PMID: 18974090.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways. Toxicol Appl Pharmacol. 2008 Dec 15; 233(3):389-403.
Yu X, Robinson JF, Gribble E, Hong SW, Sidhu JS, Faustman EM. PMID: 18929588.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Year | Publications |
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2008 | 2 | 2009 | 1 | 2010 | 8 | 2011 | 5 | 2012 | 8 | 2013 | 2 | 2014 | 1 | 2016 | 1 | 2017 | 1 | 2018 | 2 | 2019 | 3 | 2020 | 7 |
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Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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