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Joshua Robinson, PhD

Title(s)Assistant Professor, Ob/Gyn, Reproductive Sciences
SchoolSchool of Medicine
Address35 Medical Center Way
San Francisco CA 94143
Phone415-476-1573
ORCID ORCID Icon0000-0002-2421-4535 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, CAPostdoctoral2016Human Biology
    National Institute for Public Health and the Environment (RIVM), Bilthoven, NLPostdoctoral2012Bioinformatics
    University of Washington, Seattle, WAPhD2008Developmental Toxicology
    University of Washington, Seattle, WAMS2005Developmental Toxicology
    Collapse Awards and Honors
    Teratology Society2011Marie Taubeneck Award
    Society of Toxicology2013Best Paper in Toxicological Sciences (Repro/Dev)
    NIH/NIEHS2014  - 2018K99/R00 Pathway to Independence Award
    European Teratology Society2017Elsevier Award, Best Paper in Reproductive Toxicology
    Society of Toxicology2018Angelo Furgiele Young Investigator Technology Award
    Hellman Foundation2019Hellman Award for Early-Career Faculty
    Society of Birth Defects Research and Prevention2020F. Clarke Fraser Early Investigator Award

    Collapse Overview 
    Collapse Overview
    During human pregnancy, the embryo/fetus is exposed to thousands of unique environmental chemicals with unknown consequences. My research aims to determine the potential effects of these compounds and to identify the mechanistic links between environmental exposures in utero and adverse developmental outcomes (e.g., neurodevelopmental disorders, neural tube defects, placental diseases). To study these relationships, we employ three model systems: human embryonic stem cells, rodent whole embryo culture, and primary human trophoblasts. We combine classical molecular, genomic, morphological/imaging, and in silico based approaches to conduct in-depth chemical assessments and to determine modes of action. Our current investigations are focused on evaluating the effects of polybrominated diphenyl ethers (PBDEs)—commonly used flame retardants—and their alternatives on human pregnancy (in vitro). Additional research projects in the lab include: 1) establishing alternative model systems for developmental toxicology; 2) identifying human biomarkers of response; 3) developing strategies to integrate diverse toxicogenomic data; and 4) characterizing age-dependent differences in human xenobiotic metabolism. We anticipate that this research—which coalesces elements of developmental toxicology, genomics, and risk assessment—will lead to the discovery of gene-environment interactions underlying toxicity, and future prevention of specific chemical exposures that occur during human pregnancy.

    Collapse Research 
    Collapse Research Activities and Funding
    Polybrominated Diphenyl Ether Effects on Human Neuronal Development
    NIH R00ES023846Jun 1, 2016 - May 31, 2020
    Role: Principal Investigator
    Polybrominated Diphenyl Ether Effects on Human Neuronal Development
    NIH K99ES023846Jun 1, 2014 - May 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Organophosphate Flame Retardants, Highly Fluorinated Chemicals, and Biomarkers of Placental Development and Disease during Mid-Gestation. Toxicol Sci. 2021 Mar 02. Varshavsky JR, Robinson JF, Zhou Y, Puckett KA, Kwan E, Buarpung S, Aburajab R, Gaw SL, Sen S, Gao S, Smith SC, Park JS, Zakharevich I, Gerona RR, Fisher SJ, Woodruff TJ. PMID: 33677611.
      View in: PubMed   Mentions:    Fields:    
    2. Cytotrophoblast extracellular vesicles enhance decidual cell secretion of immune modulators via TNFa. Development. 2020 Sep 08; 147(17). Taylor SK, Houshdaran S, Robinson JF, Gormley MJ, Kwan EY, Kapidzic M, Schilling B, Giudice LC, Fisher SJ. PMID: 32747437.
      View in: PubMed   Mentions:    Fields:    
    3. Differences in cytochrome p450 enzyme expression and activity in fetal and adult tissues. Placenta. 2020 10; 100:35-44. Robinson JF, Hamilton EG, Lam J, Chen H, Woodruff TJ. PMID: 32818874.
      View in: PubMed   Mentions:    Fields:    
    4. Racial/ethnic and geographic differences in polybrominated diphenyl ether (PBDE) levels across maternal, placental, and fetal tissues during mid-gestation. Sci Rep. 2020 07 22; 10(1):12247. Varshavsky JR, Sen S, Robinson JF, Smith SC, Frankenfield J, Wang Y, Yeh G, Park JS, Fisher SJ, Woodruff TJ. PMID: 32699379.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    5. Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15852-15861. McNally L, Zhou Y, Robinson JF, Zhao G, Chen LM, Chen H, Kim MY, Kapidzic M, Gormley M, Hannibal R, Fisher SJ. PMID: 32576693.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Retinoids and developmental neurotoxicity: Utilizing toxicogenomics to enhance adverse outcome pathways and testing strategies. Reprod Toxicol. 2020 Jun 13; 96:102-113. Chen H, Chidboy MA, Robinson JF. PMID: 32544423.
      View in: PubMed   Mentions:    Fields:    
    7. Association of polybrominated diphenyl ether (PBDE) levels with biomarkers of placental development and disease during mid-gestation. Environ Health. 2020 06 03; 19(1):61. Varshavsky JR, Robinson JF, Zhou Y, Puckett KA, Kwan E, Buarpung S, Aburajab R, Gaw SL, Sen S, Smith SC, Frankenfield J, Park JS, Fisher SJ, Woodruff TJ. PMID: 32493340.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    8. Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface. Reprod Sci. 2020 01; 27(1):100-109. Leon-Martinez D, Robinson JF, Zdravkovic T, Genbacev O, Gormley M, Mcmaster M, Fisher SJ, Bianco K. PMID: 32046398.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Circulating Monocytes, Tissue Macrophages, and Malaria. J Trop Med. 2019; 2019:3720838. Ozarslan N, Robinson JF, Gaw SL. PMID: 31662766.
      View in: PubMed   Mentions:
    10. Using a Multi-Stage hESC Model to Characterize BDE-47 Toxicity during Neurogenesis. Toxicol Sci. 2019 Jun 07. Chen H, Seifikar H, Larocque N, Kim Y, Khatib I, Fernandez CJ, Abello N, Robinson JF. PMID: 31173147.
      View in: PubMed   Mentions: 2     Fields:    
    11. Genomic Profiling of BDE-47 Effects on Human Placental Cytotrophoblasts. Toxicol Sci. 2019 01 01; 167(1):211-226. Robinson JF, Kapidzic M, Hamilton EG, Chen H, Puckett KW, Zhou Y, Ona K, Parry E, Wang Y, Park JS, Costello JF, Fisher SJ. PMID: 30202865.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    12. Convergence of placenta biology and genetic risk for schizophrenia. Nat Med. 2018 06; 24(6):792-801. Ursini G, Punzi G, Chen Q, Marenco S, Robinson JF, Porcelli A, Hamilton EG, Mitjans M, Maddalena G, Begemann M, Seidel J, Yanamori H, Jaffe AE, Berman KF, Egan MF, Straub RE, Colantuoni C, Blasi G, Hashimoto R, Rujescu D, Ehrenreich H, Bertolino A, Weinberger DR. PMID: 29808008.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    13. Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs) in maternal and fetal tissues, and associations with fetal cytochrome P450 gene expression. Environ Int. 2018 03; 112:269-278. Zota AR, Mitro SD, Robinson JF, Hamilton EG, Park JS, Parry E, Zoeller RT, Woodruff TJ. PMID: 29316516.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsPHPublic Health
    14. Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts. Endocrinology. 2017 06 01; 158(6):1581-1594. Robinson JF, Kapidzic M, Gormley M, Ona K, Dent T, Seifikar H, Hamilton EG, Fisher SJ. PMID: 28323933.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. A genomics-based framework for identifying biomarkers of human neurodevelopmental toxicity. Reprod Toxicol. 2016 04; 60:1-10. Robinson JF, Gormley MJ, Fisher SJ. PMID: 26827931.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Rbpj links uterine transformation and embryo orientation. Cell Res. 2014 Sep; 24(9):1031-2. Robinson JF, Fisher SJ. PMID: 25145360.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    17. Valproic acid-induced gene expression responses in rat whole embryo culture and comparison across in vitro developmental and non-developmental models. Reprod Toxicol. 2013 Nov; 41:57-66. Tonk EC, Robinson JF, Verhoef A, Theunissen PT, Pennings JL, Piersma AH. PMID: 23811354.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    18. Toxicogenomic approaches in developmental toxicology testing. Methods Mol Biol. 2013; 947:451-73. Robinson JF, Piersma AH. PMID: 23138921.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    19. Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests. Toxicol Sci. 2013 Mar; 132(1):118-30. Theunissen PT, Pennings JL, van Dartel DA, Robinson JF, Kleinjans JC, Piersma AH. PMID: 23243006.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    20. Dose-response analysis of phthalate effects on gene expression in rat whole embryo culture. Toxicol Appl Pharmacol. 2012 Oct 01; 264(1):32-41. Robinson JF, Verhoef A, van Beelen VA, Pennings JL, Piersma AH. PMID: 22841773.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    21. Dose response analysis of monophthalates in the murine embryonic stem cell test assessed by cardiomyocyte differentiation and gene expression. Reprod Toxicol. 2013 Jan; 35:81-8. Schulpen SH, Robinson JF, Pennings JL, van Dartel DA, Piersma AH. PMID: 22813628.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    22. Triazole induced concentration-related gene signatures in rat whole embryo culture. Reprod Toxicol. 2012 Sep; 34(2):275-83. Robinson JF, Tonk EC, Verhoef A, Piersma AH. PMID: 22664269.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    23. Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn). Toxicol Appl Pharmacol. 2012 Aug 01; 262(3):330-40. Theunissen PT, Robinson JF, Pennings JL, van Herwijnen MH, Kleinjans JC, Piersma AH. PMID: 22634333.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    24. Transcriptomic analysis of neurulation and early organogenesis in rat embryos: an in vivo and ex vivo comparison. Toxicol Sci. 2012 Mar; 126(1):255-66. Robinson JF, Verhoef A, Piersma AH. PMID: 22262562.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    25. A comparison of gene expression responses in rat whole embryo culture and in vivo: time-dependent retinoic acid-induced teratogenic response. Toxicol Sci. 2012 Mar; 126(1):242-54. Robinson JF, Verhoef A, Pennings JL, Pronk TE, Piersma AH. PMID: 22262565.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsPHPublic Health
    26. A review of toxicogenomic approaches in developmental toxicology. Methods Mol Biol. 2012; 889:347-71. Robinson JF, Pennings JL, Piersma AH. PMID: 22669676.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    27. Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn). Toxicol Sci. 2012 Feb; 125(2):430-8. Theunissen PT, Robinson JF, Pennings JL, de Jong E, Claessen SM, Kleinjans JC, Piersma AH. PMID: 22045034.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    28. Comparison of MeHg-induced toxicogenomic responses across in vivo and in vitro models used in developmental toxicology. Reprod Toxicol. 2011 Sep; 32(2):180-8. Robinson JF, Theunissen PT, van Dartel DA, Pennings JL, Faustman EM, Piersma AH. PMID: 21664453.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells. Toxicol Sci. 2011 Aug; 122(2):437-47. Theunissen PT, Pennings JL, Robinson JF, Claessen SM, Kleinjans JC, Piersma AH. PMID: 21613230.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    30. Gene set assembly for quantitative prediction of developmental toxicity in the embryonic stem cell test. Toxicology. 2011 Jun 18; 284(1-3):63-71. Pennings JL, van Dartel DA, Robinson JF, Pronk TE, Piersma AH. PMID: 21473898.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    31. Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells. Toxicol Sci. 2011 Apr; 120(2):403-12. Yu X, Sidhu JS, Hong S, Robinson JF, Ponce RA, Faustman EM. PMID: 21252392.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    32. Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test. Toxicol Lett. 2011 Mar 05; 201(2):143-51. van Dartel DA, Pennings JL, Robinson JF, Kleinjans JC, Piersma AH. PMID: 21195148.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    33. Integrating genetic and toxicogenomic information for determining underlying susceptibility to developmental disorders. Birth Defects Res A Clin Mol Teratol. 2010 Oct; 88(10):920-30. Robinson JF, Port JA, Yu X, Faustman EM. PMID: 20706997.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsPHPublic Health
    34. Arsenic- and cadmium-induced toxicogenomic response in mouse embryos undergoing neurulation. Toxicol Appl Pharmacol. 2011 Jan 15; 250(2):117-29. Robinson JF, Yu X, Moreira EG, Hong S, Faustman EM. PMID: 20883709.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    35. Embryotoxicant-specific transcriptomic responses in rat postimplantation whole-embryo culture. Toxicol Sci. 2010 Dec; 118(2):675-85. Robinson JF, van Beelen VA, Verhoef A, Renkens MF, Luijten M, van Herwijnen MH, Westerman A, Pennings JL, Piersma AH. PMID: 20864626.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    36. A systems-based approach to investigate dose- and time-dependent methylmercury-induced gene expression response in C57BL/6 mouse embryos undergoing neurulation. Birth Defects Res B Dev Reprod Toxicol. 2010 Jun; 89(3):188-200. Robinson JF, Guerrette Z, Yu X, Hong S, Faustman EM. PMID: 20540155.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    37. Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure. Reprod Toxicol. 2010 Sep; 30(2):284-91. Robinson JF, Griffith WC, Yu X, Hong S, Kim E, Faustman EM. PMID: 20493249.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    38. Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos. Toxicol Appl Pharmacol. 2010 Jun 15; 245(3):310-25. Moreira EG, Yu X, Robinson JF, Griffith W, Hong SW, Beyer RP, Bammler TK, Faustman EM. PMID: 20350560.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    39. A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast. Toxicol Sci. 2010 Apr; 114(2):356-77. Yu X, Robinson JF, Sidhu JS, Hong S, Faustman EM. PMID: 20061341.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    40. Embryonic toxicokinetic and dynamic differences underlying strain sensitivity to cadmium during neurulation. Reprod Toxicol. 2010 Jun; 29(3):279-85. Robinson JF, Yu X, Hong S, Zhou C, Kim N, DeMasi D, Faustman EM. PMID: 20025959.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    41. Cadmium-induced differential toxicogenomic response in resistant and sensitive mouse strains undergoing neurulation. Toxicol Sci. 2009 Jan; 107(1):206-19. Robinson JF, Yu X, Hong S, Griffith WC, Beyer R, Kim E, Faustman EM. PMID: 18974090.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    42. Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways. Toxicol Appl Pharmacol. 2008 Dec 15; 233(3):389-403. Yu X, Robinson JF, Gribble E, Hong SW, Sidhu JS, Faustman EM. PMID: 18929588.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
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