Joshua Robinson, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentOb/Gyn, Reproductive Sciences
Address513 Parnassus Ave
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of California, San Francisco, CAPostdoctoral2016Human Biology
    National Institute for Public Health and the Environment (RIVM), Bilthoven, NLPostdoctoral2012Bioinformatics
    University of Washington, Seattle, WAPhD2008Developmental Toxicology
    University of Washington, Seattle, WAMS2005Developmental Toxicology
    Collapse Awards and Honors
    NIH/NIEHS2014  - 2018K99/R00 Pathway to Independence Award

    Collapse Overview 
    Collapse Overview
    During human pregnancy, the embryo/fetus is exposed to thousands of unique environmental chemicals with unknown consequences. My research aims to determine the potential effects of these compounds and to identify the mechanistic links between environmental exposures in utero and adverse developmental outcomes (e.g., neurodevelopmental disorders, neural tube defects, placental diseases). To study these relationships, we employ three model systems: human embryonic stem cells, rodent whole embryo culture, and primary human trophoblasts. We combine classical molecular, genomic, morphological/imaging, and in silico based approaches to conduct in-depth chemical assessments and to determine modes of action. Our current investigations are focused on evaluating the effects of polybrominated diphenyl ethers (PBDEs)—commonly used flame retardants—and their alternatives on human pregnancy (in vitro). Additional research projects in the lab include: 1) establishing alternative model systems for developmental toxicology; 2) identifying human biomarkers of response; 3) developing strategies to integrate diverse toxicogenomic data; and 4) characterizing age-dependent differences in human xenobiotic metabolism. We anticipate that this research—which coalesces elements of developmental toxicology, genomics, and risk assessment—will lead to the discovery of gene-environment interactions underlying toxicity, and future prevention of specific chemical exposures that occur during human pregnancy.

    Collapse Research 
    Collapse Research Activities and Funding
    Polybrominated Diphenyl Ether Effects on Human Neuronal Development
    NIH/NIEHS R00ES023846Jun 1, 2016 - May 31, 2019
    Role: Principal Investigator
    Polybrominated Diphenyl Ether Effects on Human Neuronal Development
    NIH/NIEHS K99ES023846Jun 1, 2014 - May 31, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse Student Projects

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ursini G, Punzi G, Chen Q, Marenco S, Robinson JF, Porcelli A, Hamilton EG, Mitjans M, Maddalena G, Begemann M, Seidel J, Yanamori H, Jaffe AE, Berman KF, Egan MF, Straub RE, Colantuoni C, Blasi G, Hashimoto R, Rujescu D, Ehrenreich H, Bertolino A, Weinberger DR. Convergence of placenta biology and genetic risk for schizophrenia. Nat Med. 2018 Jun; 24(6):792-801. PMID: 29808008.
      View in: PubMed
    2. Zota AR, Mitro SD, Robinson JF, Hamilton EG, Park JS, Parry E, Zoeller RT, Woodruff TJ. Polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDE metabolites (OH-PBDEs) in maternal and fetal tissues, and associations with fetal cytochrome P450 gene expression. Environ Int. 2018 Jan 06; 112:269-278. PMID: 29316516.
      View in: PubMed
    3. Robinson JF, Kapidzic M, Gormley M, Ona K, Dent T, Seifikar H, Hamilton EG, Fisher SJ. Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts. Endocrinology. 2017 06 01; 158(6):1581-1594. PMID: 28323933.
      View in: PubMed
    4. Robinson JF, Gormley MJ, Fisher SJ. A genomics-based framework for identifying biomarkers of human neurodevelopmental toxicity. Reprod Toxicol. 2016 04; 60:1-10. PMID: 26827931; PMCID: PMC4867143 [Available on 04/01/17].
    5. Robinson JF, Fisher SJ. Rbpj links uterine transformation and embryo orientation. Cell Res. 2014 Sep; 24(9):1031-2. PMID: 25145360; PMCID: PMC4152736.
    6. Tonk EC, Robinson JF, Verhoef A, Theunissen PT, Pennings JL, Piersma AH. Valproic acid-induced gene expression responses in rat whole embryo culture and comparison across in vitro developmental and non-developmental models. Reprod Toxicol. 2013 Nov; 41:57-66. PMID: 23811354.
      View in: PubMed
    7. Robinson JF, Piersma AH. Toxicogenomic approaches in developmental toxicology testing. Methods Mol Biol. 2013; 947:451-73. PMID: 23138921.
      View in: PubMed
    8. Theunissen PT, Pennings JL, van Dartel DA, Robinson JF, Kleinjans JC, Piersma AH. Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests. Toxicol Sci. 2013 Mar; 132(1):118-30. PMID: 23243006.
      View in: PubMed
    9. Robinson JF, Verhoef A, van Beelen VA, Pennings JL, Piersma AH. Dose-response analysis of phthalate effects on gene expression in rat whole embryo culture. Toxicol Appl Pharmacol. 2012 Oct 01; 264(1):32-41. PMID: 22841773.
      View in: PubMed
    10. Schulpen SH, Robinson JF, Pennings JL, van Dartel DA, Piersma AH. Dose response analysis of monophthalates in the murine embryonic stem cell test assessed by cardiomyocyte differentiation and gene expression. Reprod Toxicol. 2013 Jan; 35:81-8. PMID: 22813628.
      View in: PubMed
    11. Robinson JF, Tonk EC, Verhoef A, Piersma AH. Triazole induced concentration-related gene signatures in rat whole embryo culture. Reprod Toxicol. 2012 Sep; 34(2):275-83. PMID: 22664269.
      View in: PubMed
    12. Theunissen PT, Robinson JF, Pennings JL, van Herwijnen MH, Kleinjans JC, Piersma AH. Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn). Toxicol Appl Pharmacol. 2012 Aug 01; 262(3):330-40. PMID: 22634333.
      View in: PubMed
    13. Robinson JF, Verhoef A, Piersma AH. Transcriptomic analysis of neurulation and early organogenesis in rat embryos: an in vivo and ex vivo comparison. Toxicol Sci. 2012 Mar; 126(1):255-66. PMID: 22262562.
      View in: PubMed
    14. Robinson JF, Verhoef A, Pennings JL, Pronk TE, Piersma AH. A comparison of gene expression responses in rat whole embryo culture and in vivo: time-dependent retinoic acid-induced teratogenic response. Toxicol Sci. 2012 Mar; 126(1):242-54. PMID: 22262565.
      View in: PubMed
    15. Robinson JF, Pennings JL, Piersma AH. A review of toxicogenomic approaches in developmental toxicology. Methods Mol Biol. 2012; 889:347-71. PMID: 22669676.
      View in: PubMed
    16. Theunissen PT, Robinson JF, Pennings JL, de Jong E, Claessen SM, Kleinjans JC, Piersma AH. Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn). Toxicol Sci. 2012 Feb; 125(2):430-8. PMID: 22045034.
      View in: PubMed
    17. Robinson JF, Theunissen PT, van Dartel DA, Pennings JL, Faustman EM, Piersma AH. Comparison of MeHg-induced toxicogenomic responses across in vivo and in vitro models used in developmental toxicology. Reprod Toxicol. 2011 Sep; 32(2):180-8. PMID: 21664453.
      View in: PubMed
    18. Theunissen PT, Pennings JL, Robinson JF, Claessen SM, Kleinjans JC, Piersma AH. Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells. Toxicol Sci. 2011 Aug; 122(2):437-47. PMID: 21613230.
      View in: PubMed
    19. Pennings JL, van Dartel DA, Robinson JF, Pronk TE, Piersma AH. Gene set assembly for quantitative prediction of developmental toxicity in the embryonic stem cell test. Toxicology. 2011 Jun 18; 284(1-3):63-71. PMID: 21473898.
      View in: PubMed
    20. Yu X, Sidhu JS, Hong S, Robinson JF, Ponce RA, Faustman EM. Cadmium induced p53-dependent activation of stress signaling, accumulation of ubiquitinated proteins, and apoptosis in mouse embryonic fibroblast cells. Toxicol Sci. 2011 Apr; 120(2):403-12. PMID: 21252392; PMCID: PMC3061482.
    21. van Dartel DA, Pennings JL, Robinson JF, Kleinjans JC, Piersma AH. Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test. Toxicol Lett. 2011 Mar 05; 201(2):143-51. PMID: 21195148.
      View in: PubMed
    22. Robinson JF, Port JA, Yu X, Faustman EM. Integrating genetic and toxicogenomic information for determining underlying susceptibility to developmental disorders. Birth Defects Res A Clin Mol Teratol. 2010 Oct; 88(10):920-30. PMID: 20706997.
      View in: PubMed
    23. Robinson JF, Yu X, Moreira EG, Hong S, Faustman EM. Arsenic- and cadmium-induced toxicogenomic response in mouse embryos undergoing neurulation. Toxicol Appl Pharmacol. 2011 Jan 15; 250(2):117-29. PMID: 20883709; PMCID: PMC3014392.
    24. Robinson JF, van Beelen VA, Verhoef A, Renkens MF, Luijten M, van Herwijnen MH, Westerman A, Pennings JL, Piersma AH. Embryotoxicant-specific transcriptomic responses in rat postimplantation whole-embryo culture. Toxicol Sci. 2010 Dec; 118(2):675-85. PMID: 20864626.
      View in: PubMed
    25. Robinson JF, Guerrette Z, Yu X, Hong S, Faustman EM. A systems-based approach to investigate dose- and time-dependent methylmercury-induced gene expression response in C57BL/6 mouse embryos undergoing neurulation. Birth Defects Res B Dev Reprod Toxicol. 2010 Jun; 89(3):188-200. PMID: 20540155; PMCID: PMC3726008.
    26. Robinson JF, Griffith WC, Yu X, Hong S, Kim E, Faustman EM. Methylmercury induced toxicogenomic response in C57 and SWV mouse embryos undergoing neural tube closure. Reprod Toxicol. 2010 Sep; 30(2):284-91. PMID: 20493249; PMCID: PMC2924281.
    27. Moreira EG, Yu X, Robinson JF, Griffith W, Hong SW, Beyer RP, Bammler TK, Faustman EM. Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos. Toxicol Appl Pharmacol. 2010 Jun 15; 245(3):310-25. PMID: 20350560; PMCID: PMC2881838.
    28. Yu X, Robinson JF, Sidhu JS, Hong S, Faustman EM. A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast. Toxicol Sci. 2010 Apr; 114(2):356-77. PMID: 20061341; PMCID: PMC2840217.
    29. Robinson JF, Yu X, Hong S, Zhou C, Kim N, DeMasi D, Faustman EM. Embryonic toxicokinetic and dynamic differences underlying strain sensitivity to cadmium during neurulation. Reprod Toxicol. 2010 Jun; 29(3):279-85. PMID: 20025959; PMCID: PMC2855762.
    30. Robinson JF, Yu X, Hong S, Griffith WC, Beyer R, Kim E, Faustman EM. Cadmium-induced differential toxicogenomic response in resistant and sensitive mouse strains undergoing neurulation. Toxicol Sci. 2009 Jan; 107(1):206-19. PMID: 18974090; PMCID: PMC2768398.
    31. Yu X, Robinson JF, Gribble E, Hong SW, Sidhu JS, Faustman EM. Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient cells through differential gene pathways. Toxicol Appl Pharmacol. 2008 Dec 15; 233(3):389-403. PMID: 18929588; PMCID: PMC2677763.
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