Matthew Spinelli, MD, MAS

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
Phone628-206-2400
ORCID ORCID Icon0000-0001-6368-8664 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Columbia UniversityB.A.2008Italian Literature
    Mount Sinai School of MedicineM.D.2013Medicine
    University of California, San FranciscoResidency2016Internal Medicine
    University of California, San FranciscoFellowship2018Infectious Diseases
    University of California, San FranciscoM.A.S.2019Epidemiology & Implementation Science
    University of California, San Francisco, Ward 86Fellowship2020HIV Clinical and Research Fellowship

    Collapse Overview 
    Collapse Overview
    I am HIV/ID physician with training in implementation science methods who uses these approaches to support pre-exposure prophylaxis (PrEP) implementation, PrEP/HIV ART adherence, and PrEP persistence/HIV retention in care. A key tool we are using in this work is a point-of-care urine tenofovir test that can provide real-time adherence information to clinicians to drive adherence interventions. More recently, I lead projects on the intersection of the HIV and COVID-19 epidemics using epidemiological, translational, and sociobehavioral methods. In terms of educational initiatives, I am the co-director of the Implementation Science Short Course and the Individual-Level Intervention Design course in the UCSF Department of Epidemiology. Finally, I am a member of the Partnership for Research in Implementation Science for Equity, a collaboration between the SF Department of Public Health and UCSF that seeks to use implementation science methods to advance health equity.

    Collapse Research 
    Collapse Research Activities and Funding
    Evaluation of the Interplay between HIV and COVID-19 in a large urban safety-net HIV clinic
    NIH R01AI158013Aug 1, 2020 - Jul 31, 2024
    Role: Co-Principal Investigator
    PrEP Point-of-Care Brief-Intervention for Adherence among Young Men Who Have Sex with Men (PrEP2-BAY Study)
    NIH K23MH122286Jan 24, 2020 - Dec 31, 2024
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. SARS-CoV-2 vaccination in people with HIV. Lancet HIV. 2021 Jun 18. Spinelli MA. PMID: 34153265.
      View in: PubMed   Mentions:    Fields:    
    2. Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis. Clin Infect Dis. 2021 06 01; 72(11):2025-2028. Spinelli MA, Lowery B, Shuford JA, Spindler J, Kearney MF, McFarlane JR, McDonald C, Okochi H, Phung N, Kuncze K, Jee K, Johannessen D, Anderson PL, Smith DK, Defechereux P, Grant RM, Gandhi M. PMID: 32686825.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    3. Brief Report: No Difference in Urine Tenofovir Levels in Patients Living with HIV on Unboosted vs Dose-Adjusted Boosted Tenofovir Alafenamide. J Acquir Immune Defic Syndr. 2021 May 12. Johnson KA, Okochi H, Glidden DV, Gandhi M, Spinelli M. PMID: 33990489.
      View in: PubMed   Mentions:    Fields:    
    4. SARS-CoV-2 seroprevalence, and IgG concentration and pseudovirus neutralising antibody titres after infection, compared by HIV status: a matched case-control observational study. Lancet HIV. 2021 06; 8(6):e334-e341. Spinelli MA, Lynch KL, Yun C, Glidden DV, Peluso MJ, Henrich TJ, Gandhi M, Brown LB. PMID: 33933189.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    5. Lower Urine Tenofovir Concentrations among Individuals Taking Tenofovir Alafenamide versus Tenofovir Disoproxil Fumarate: Implications for Point-of-Care Testing. Open Forum Infectious Diseases. 2021 Apr 17. Kelly A Johnson, Xin Niu, David V Glidden, Jose R Castillo-Mancilla, Jenna Yager, Samantha MaWhinney, Mary Morrow, Hideaki Okochi, Tim R Cressey, Paul K Drain, Monica Gandhi, Peter L Anderson, Matthew A Spinelli. .
      View in: Publisher Site   Mentions:
    6. Lowering SARS-CoV-2 viral load might affect transmission but not disease severity in secondary cases - Authors' reply. Lancet Infect Dis. 2021 Apr 14. Spinelli MA, Rutherford G, Gandhi M. PMID: 33864804.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Tenofovir and emtricitabine concentrations in hair are comparable between individuals on tenofovir disoproxil fumarate versus tenofovir alafenamide-based ART. Drug Test Anal. 2021 Jul; 13(7):1354-1370. Okochi H, Louie A, Phung N, Zhang K, Tallerico RM, Kuncze K, Spinelli MA, Koss CA, Benet LZ, Gandhi M. PMID: 33742745.
      View in: PubMed   Mentions:
    8. Disparities in Integrase Inhibitor Usage in the Modern HIV Treatment Era: A Population-Based Study in a US City. Open Forum Infect Dis. 2021 Jul; 8(7):ofab139. Spinelli MA, Hessol NA, Schwarcz SK, Scheer S, Gandhi M, Chin Hsu L. PMID: 34250184.
      View in: PubMed   Mentions:
    9. Rapid implementation of a cohort for the study of post-acute sequelae of SARS-CoV-2 infection/COVID-19. medRxiv. 2021 Mar 12. Peluso MJ, Kelly JD, Lu S, Goldberg SA, Davidson MC, Mathur S, Durstenfeld MS, Spinelli MA, Hoh R, Tai V, Fehrman EA, Torres L, Hernandez Y, Williams MC, Arreguin MI, Bautista JA, Ngo LH, Deswal M, Munter SE, Martinez EO, Anglin KA, Romero MD, Tavs J, Rugart PR, Chen JY, Sans HM, Murray VW, Ellis PK, Donohue KC, Massachi JA, Weiss JO, Mehdi I, Pineda-Ramirez J, Tang AF, Wenger M, Assenzio M, Yuan Y, Krone M, Rutishauser RL, Rodriguez-Barraquer I, Greenhouse B, Sauceda JA, Gandhi M, Hsue PY, Henrich TJ, Deeks SG, Martin JN. PMID: 33758895.
      View in: PubMed   Mentions:
    10. Characterizing the COVID-19 illness experience to inform the study of post-acute sequalae and recovery: a qualitative study. medRxiv. 2021 Mar 12. Santiago-Rodriguez EI, Maiorana A, Peluso MJ, Hoh R, Tai V, Fehrman EA, Hernandez Y, Torres L, Spinelli MA, Gandhi M, Kelly JD, Martin JN, Henrich TJ, Deeks SG, Sauceda JA. PMID: 33758881.
      View in: PubMed   Mentions:
    11. Tenofovir-based PrEP for COVID-19: an untapped opportunity? AIDS. 2021 Mar 11. DeJong C, Spinelli MA, Okochi H, Gandhi M. PMID: 33710026.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    12. SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay. medRxiv. 2021 Mar 05. Peluso MJ, Takahashi S, Hakim J, Kelly JD, Torres L, Iyer NS, Turcios K, Janson O, Munter SE, Thanh C, Nixon CC, Hoh R, Tai V, Fehrman EA, Hernandez Y, Spinelli MA, Gandhi M, Palafox MA, Vallari A, Rodgers MA, Prostko J, Hackett J, Trinh L, Wrin T, Petroplolous CJ, Chiu CY, Norris PJ, DiGermanio C, Stone M, Busch MP, Elledge SK, Zhou XX, Wells JA, Shu A, Kurtz TW, Pak JE, Wu W, Burbelo PD, Cohen JI, Rutishauser RL, Martin JN, Deeks SG, Henrich TJ, Rodriguez-Barraquer I, Greenhouse B. PMID: 33688675.
      View in: PubMed   Mentions:
    13. Long-Term SARS-CoV-2-Specific Immune and Inflammatory Responses Across a Clinically Diverse Cohort of Individuals Recovering from COVID-19. medRxiv. 2021 Mar 01. Peluso MJ, Deitchman AN, Torres L, Iyer NS, Nixon CC, Munter SE, Donatelli J, Thanh C, Takahashi S, Hakim J, Turcios K, Janson O, Hoh R, Tai V, Hernandez Y, Fehrman E, Spinelli MA, Gandhi M, Trinh L, Wrin T, Petropoulos CJ, Aweeka FT, Rodriguez-Barraquer I, Kelly JD, Martin JN, Deeks SG, Greenhouse B, Rutishauser RL, Henrich TJ. PMID: 33688685.
      View in: PubMed   Mentions:
    14. Importance of non-pharmaceutical interventions in lowering the viral inoculum to reduce susceptibility to infection by SARS-CoV-2 and potentially disease severity. Lancet Infect Dis. 2021 Feb 22. Spinelli MA, Glidden DV, Gennatas ED, Bielecki M, Beyrer C, Rutherford G, Chambers H, Goosby E, Gandhi M. PMID: 33631099.
      View in: PubMed   Mentions: 2     Fields:    
    15. Sensitivity and Specificity of the National Death Index for Multiple Causes of Death in People With HIV. Public Health Rep. 2021 Feb 04; 33354920977840. Schwarcz S, Hessol NA, Spinelli MA, Hsu LC, Wlodarczyk D, Tulsky J, Newman MD, Buchbinder SP. PMID: 33541227.
      View in: PubMed   Mentions:    Fields:    
    16. Urine Tenofovir Levels Measured Using a Novel Immunoassay Predict Human Immunodeficiency Virus Protection. Clin Infect Dis. 2021 02 01; 72(3):486-489. Stalter RM, Baeten JM, Donnell D, Spinelli MA, Glidden DV, Rodrigues WC, Wang G, Vincent M, Mugo N, Mujugira A, Marzinke M, Hendrix C, Gandhi M, Partners PrEP Study Team . PMID: 33527128.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    17. The interplay between HIV and COVID-19: summary of the data and responses to date. Curr Opin HIV AIDS. 2021 01; 16(1):63-73. Brown LB, Spinelli MA, Gandhi M. PMID: 33186229.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsPHPublic Health
    18. Pragmatic randomized trial of a pre-visit intervention to improve the quality of telemedicine visits for vulnerable patients living with HIV. J Telemed Telecare. 2020 Dec 20; 1357633X20976036. Hickey MD, Sergi F, Zhang K, Spinelli MA, Black D, Sola C, Blaz V, Nguyen JQ, Oskarsson J, Gandhi M, Havlir DV. PMID: 33342328.
      View in: PubMed   Mentions: 1     Fields:    
    19. Viral suppression rates in a safety-net HIV clinic in San Francisco destabilized during COVID-19. AIDS. 2020 12 01; 34(15):2328-2331. Spinelli MA, Hickey MD, Glidden DV, Nguyen JQ, Oskarsson JJ, Havlir D, Gandhi M. PMID: 32910069.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCellsPHPublic Health
    20. Understanding PrEP Persistence: Provider and Patient Perspectives. AIDS Behav. 2020 Sep; 24(9):2509-2519. Laborde ND, Kinley PM, Spinelli M, Vittinghoff E, Whitacre R, Scott HM, Buchbinder SP. PMID: 32048078.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    21. The importance of PrEP persistence in preventing HIV infections on PrEP. J Int AIDS Soc. 2020 08; 23(8):e25578. Spinelli MA, Laborde N, Kinley P, Whitacre R, Scott HM, Walker N, Liu AY, Gandhi M, Buchbinder SP. PMID: 32844591.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    22. Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions. Curr HIV/AIDS Rep. 2020 08; 17(4):301-314. Spinelli MA, Haberer JE, Chai PR, Castillo-Mancilla J, Anderson PL, Gandhi M. PMID: 32424549.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCellsPHPublic Health
    23. Pre-exposure Prophylaxis Persistence Is a Critical Issue in PrEP Implementation. Clin Infect Dis. 2020 07 27; 71(3):583-585. Spinelli MA, Buchbinder SP. PMID: 31509603.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    24. Urine Tenofovir Levels Measured by a Novel Immunoassay Predict HIV Protection. Clin Infect Dis. 2020 Jun 22. Stalter RM, Baeten JM, Donnell D, Spinelli MA, Glidden DV, Rodrigues WC, Wang G, Vincent M, Mugo N, Mujugira A, Marzinke M, Hendrix C, Gandhi M. PMID: 32569370.
      View in: PubMed   Mentions: 1     Fields:    
    25. Brief Report: High Accuracy of a Real-Time Urine Antibody-Based Tenofovir Point-of-Care Test Compared With Laboratory-Based ELISA in Diverse Populations. J Acquir Immune Defic Syndr. 2020 06 01; 84(2):149-152. Spinelli MA, Rodrigues WC, Wang G, Vincent M, Glidden DV, Okochi H, Stalter R, Defechereux P, Deutsch M, Grant RM, Ngure K, Mugo NR, Baeten JM, Gandhi M, Partners PrEP Study Team . PMID: 32167963.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Testing a Real-Time Tenofovir Urine Adherence Assay for Monitoring and Providing Feedback to Preexposure Prophylaxis in Kenya (PUMA): Protocol for a Pilot Randomized Controlled Trial. JMIR Res Protoc. 2020 Apr 02; 9(4):e15029. Drain P, Ngure K, Mugo N, Spinelli M, Chatterjee P, Bacchetti P, Glidden D, Baeten J, Gandhi M. PMID: 32238341.
      View in: PubMed   Mentions:
    27. Missed opportunities to prevent HIV infections among pre-exposure prophylaxis users: a population-based mixed methods study, San Francisco, United States. J Int AIDS Soc. 2020 04; 23(4):e25472. Spinelli MA, Laborde N, Kinley P, Whitacre R, Scott HM, Walker N, Liu AY, Gandhi M, Buchbinder SP. PMID: 32294338.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    28. Development and validation of the first point-of-care assay to objectively monitor adherence to HIV treatment and prevention in real-time in routine settings. AIDS. 2020 02 01; 34(2):255-260. Gandhi M, Wang G, King R, Rodrigues WC, Vincent M, Glidden DV, Cressey TR, Bacchetti P, Spinelli MA, Okochi H, Siriprakaisil O, Klinbuayaem V, Mugo NR, Ngure K, Drain PK, Baeten JM. PMID: 31634188.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    29. Racial/ethnic and HIV risk category disparities in preexposure prophylaxis discontinuation among patients in publicly funded primary care clinics. AIDS. 2019 11 15; 33(14):2189-2195. Scott HM, Spinelli M, Vittinghoff E, Morehead-Gee A, Hirozawa A, James C, Hammer H, Liu A, Gandhi M, Buchbinder S. PMID: 31436610.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    30. Homelessness at diagnosis is associated with death among people with HIV in a population-based study of a US city. AIDS. 2019 09 01; 33(11):1789-1794. Spinelli MA, Hessol NA, Schwarcz S, Hsu L, Parisi MK, Pipkin S, Scheer S, Havlir D, Buchbinder SP. PMID: 31259765.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    31. Impact of Estimated Pre-Exposure Prophylaxis (PrEP) Adherence Patterns on Bone Mineral Density in a Large PrEP Demonstration Project. AIDS Res Hum Retroviruses. 2019 09; 35(9):788-793. Spinelli MA, Glidden DV, Anderson PL, Gandhi M, McMahan VM, Defechereux P, Schechter M, Veloso VG, Chariyalertsak S, Guanira JV, Bekker LG, Buchbinder SP, Grant RM. PMID: 31119944.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    32. Brief Report: Short-Term Adherence Marker to PrEP Predicts Future Nonretention in a Large PrEP Demo Project: Implications for Point-of-Care Adherence Testing. . 2019 06 01; 81(2):158-162. Spinelli MA, Glidden DV, Anderson PL, Gandhi M, Cohen S, Vittinghoff E, Coleman ME, Scott H, Bacon O, Elion R, Kolber MA, Buchbinder SP, Liu AY. PMID: 31095005.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansPHPublic Health
    33. Brief Report: Validation of a Urine Tenofovir Immunoassay for Adherence Monitoring to PrEP and ART and Establishing the Cutoff for a Point-of-Care Test. . 2019 05 01; 81(1):72-77. Gandhi M, Bacchetti P, Spinelli MA, Okochi H, Baeten JM, Siriprakaisil O, Klinbuayaem V, Rodrigues WC, Wang G, Vincent M, Cressey TR, Drain PK. PMID: 30664078.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansPHPublic Health
    34. Addressing the Sexually Transmitted Infection and HIV Syndemic. JAMA. 2019 04 09; 321(14):1356-1358. Gandhi M, Spinelli MA, Mayer KH. PMID: 30964514.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    35. Low tenofovir level in urine by a novel immunoassay is associated with seroconversion in a preexposure prophylaxis demonstration project. AIDS. 2019 04 01; 33(5):867-872. Spinelli MA, Glidden DV, Rodrigues WC, Wang G, Vincent M, Okochi H, Kuncze K, Mehrotra M, Defechereux P, Buchbinder SP, Grant RM, Gandhi M. PMID: 30649051.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansPHPublic Health
    36. High Interest in Doxycycline for Sexually Transmitted Infection Postexposure Prophylaxis in a Multicity Survey of Men Who Have Sex With Men Using a Social Networking Application. Sex Transm Dis. 2019 04; 46(4):e32-e34. Spinelli MA, Scott HM, Vittinghoff E, Liu AY, Coleman K, Buchbinder SP. PMID: 30870327.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    37. Missed Visits Associated With Future Preexposure Prophylaxis (PrEP) Discontinuation Among PrEP Users in a Municipal Primary Care Health Network. Open Forum Infect Dis. 2019 Apr; 6(4):ofz101. Spinelli MA, Scott HM, Vittinghoff E, Liu AY, Gonzalez R, Morehead-Gee A, Gandhi M, Buchbinder SP. PMID: 30949540.
      View in: PubMed   Mentions:
    38. 2272. High Interest in Doxycycline for Sexually Transmitted Infection Post-Exposure Prophylaxis (Doxy-PEP) in a Multi-city Survey of Men Having Sex With Men (MSM) Using a Social-Networking App. Open Forum Infectious Diseases. 2018 Nov 26; 5(suppl_1):s672-s673. Matthew A Spinelli, Hyman Scott, Eric Vittinghoff, Albert Y Liu, Kenneth Coleman, Monica Gandhi, Susan P Buchbinder. .
      View in: Publisher Site   Mentions:
    39. Brief Report: A Panel Management and Patient Navigation Intervention Is Associated With Earlier PrEP Initiation in a Safety-Net Primary Care Health System. . 2018 11 01; 79(3):347-351. Spinelli MA, Scott HM, Vittinghoff E, Liu AY, Morehead-Gee A, Gonzalez R, Gandhi M, Buchbinder SP. PMID: 30085955.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansPHPublic Health
    40. Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence. EClinicalMedicine. 2018 Aug-Sep; 2-3:22-28. Gandhi M, Bacchetti P, Rodrigues WC, Spinelli M, Koss CA, Drain PK, Baeten JM, Mugo NR, Ngure K, Benet LZ, Okochi H, Wang G, Vincent M. PMID: 30906930.
      View in: PubMed   Mentions:
    41. Provider Adherence to Pre-exposure Prophylaxis Monitoring Guidelines in a Large Primary Care Network. Open Forum Infect Dis. 2018 Jun; 5(6):ofy099. Spinelli MA, Scott HM, Vittinghoff E, Liu AY, Morehead-Gee A, Gonzalez R, Buchbinder SP. PMID: 29977959.
      View in: PubMed   Mentions:
    42. Food Insecurity is Associated with Poor HIV Outcomes Among Women in the United States. AIDS Behav. 2017 Dec; 21(12):3473-3477. Spinelli MA, Frongillo EA, Sheira LA, Palar K, Tien PC, Wilson T, Merenstein D, Cohen M, Adedimeji A, Wentz E, Adimora AA, Metsch LR, Turan JM, Kushel MB, Weiser SD. PMID: 29119474.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    43. Factors associated with substance use in older homeless adults: Results from the HOPE HOME study. Subst Abus. 2017 Jan-Mar; 38(1):88-94. Spinelli MA, Ponath C, Tieu L, Hurstak EE, Guzman D, Kushel M. PMID: 27897965.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    44. Common tasks in microscopic and ultrastructural image analysis using ImageJ. Ultrastruct Pathol. 2007 Nov-Dec; 31(6):401-7. Papadopulos F, Spinelli M, Valente S, Foroni L, Orrico C, Alviano F, Pasquinelli G. PMID: 18098058.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    45. Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. J Virol. 2007 Nov; 81(22):12582-95. Chen P, Hübner W, Spinelli MA, Chen BK. PMID: 17728240.
      View in: PubMed   Mentions: 216     Fields:    Translation:HumansCells
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