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Matthew Spinelli, MD, MAS

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone628-206-2400
ORCID ORCID Icon0000-0001-6368-8664 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Columbia UniversityB.A.2008Italian Literature
    Mount Sinai School of MedicineM.D.2013Medicine
    University of California, San FranciscoResidency2016Internal Medicine
    University of California, San FranciscoFellowship2018Infectious Diseases
    University of California, San FranciscoM.A.S.2019Clinical Research & Implementation Science

    Collapse Overview 
    Collapse Overview
    I am interested in HIV/AIDS research with particular interest in HIV prevention, pre-exposure prophylaxis (PrEP) implementation, adherence, and PrEP persistence (remaining on PrEP over time). My research interests focus on factors affecting retention in care and PrEP persistence in domestic populations, particularly examining provider and systems factors that could improve PrEP persistence.

    Collapse Research 
    Collapse Research Activities and Funding
    Evaluation of the Interplay between HIV and COVID-19 in a large urban safety-net HIV clinic
    NIH R01AI158013Aug 1, 2020 - Jul 31, 2024
    Role: Co-Principal Investigator
    PrEP Point-of-Care Brief-Intervention for Adherence among Young Men Who Have Sex with Men (PrEP2-BAY Study)
    NIH K23MH122286Jan 24, 2020 - Dec 31, 2024
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Importance of non-pharmaceutical interventions in lowering the viral inoculum to reduce susceptibility to infection by SARS-CoV-2 and potentially disease severity. Lancet Infect Dis. 2021 Feb 22. Spinelli MA, Glidden DV, Gennatas ED, Bielecki M, Beyrer C, Rutherford G, Chambers H, Goosby E, Gandhi M. PMID: 33631099.
      View in: PubMed   Mentions:    Fields:    
    2. Sensitivity and Specificity of the National Death Index for Multiple Causes of Death in People With HIV. Public Health Rep. 2021 Feb 04; 33354920977840. Schwarcz S, Hessol NA, Spinelli MA, Hsu LC, Wlodarczyk D, Tulsky J, Newman MD, Buchbinder SP. PMID: 33541227.
      View in: PubMed   Mentions:    Fields:    
    3. Urine Tenofovir Levels Measured Using a Novel Immunoassay Predict Human Immunodeficiency Virus Protection. Clin Infect Dis. 2021 Feb 01; 72(3):486-489. Stalter RM, Baeten JM, Donnell D, Spinelli MA, Glidden DV, Rodrigues WC, Wang G, Vincent M, Mugo N, Mujugira A, Marzinke M, Hendrix C, Gandhi M. PMID: 33527128.
      View in: PubMed   Mentions:    Fields:    
    4. The interplay between HIV and COVID-19: summary of the data and responses to date. Curr Opin HIV AIDS. 2021 01; 16(1):63-73. Brown LB, Spinelli MA, Gandhi M. PMID: 33186229.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    5. Pragmatic randomized trial of a pre-visit intervention to improve the quality of telemedicine visits for vulnerable patients living with HIV. J Telemed Telecare. 2020 Dec 20; 1357633X20976036. Hickey MD, Sergi F, Zhang K, Spinelli MA, Black D, Sola C, Blaz V, Nguyen JQ, Oskarsson J, Gandhi M, Havlir DV. PMID: 33342328.
      View in: PubMed   Mentions:    Fields:    
    6. Viral suppression rates in a safety-net HIV clinic in San Francisco destabilized during COVID-19. AIDS. 2020 12 01; 34(15):2328-2331. Spinelli MA, Hickey MD, Glidden DV, Nguyen JQ, Oskarsson JJ, Havlir D, Gandhi M. PMID: 32910069.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    7. Understanding PrEP Persistence: Provider and Patient Perspectives. AIDS Behav. 2020 Sep; 24(9):2509-2519. Laborde ND, Kinley PM, Spinelli M, Vittinghoff E, Whitacre R, Scott HM, Buchbinder SP. PMID: 32048078.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    8. Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions. Curr HIV/AIDS Rep. 2020 08; 17(4):301-314. Spinelli MA, Haberer JE, Chai PR, Castillo-Mancilla J, Anderson PL, Gandhi M. PMID: 32424549.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    9. The importance of PrEP persistence in preventing HIV infections on PrEP. J Int AIDS Soc. 2020 Aug; 23(8):e25578. Spinelli MA, Laborde N, Kinley P, Whitacre R, Scott HM, Walker N, Liu AY, Gandhi M, Buchbinder SP. PMID: 32844591.
      View in: PubMed   Mentions:    Fields:    
    10. Pre-exposure Prophylaxis Persistence Is a Critical Issue in PrEP Implementation. Clin Infect Dis. 2020 Jul 27; 71(3):583-585. Spinelli MA, Buchbinder SP. PMID: 31509603.
      View in: PubMed   Mentions: 3     Fields:    
    11. Use of Drug-Level Testing and Single-Genome Sequencing to Unravel a Case of HIV Seroconversion on PrEP. Clin Infect Dis. 2020 Jul 20. Spinelli MA, Lowery B, Shuford JA, Spindler J, Kearney MF, McFarlane JR, McDonald C, Okochi H, Phung N, Kuncze K, Jee K, Johannessen D, Anderson PL, Smith DK, Defechereux P, Grant RM, Gandhi M. PMID: 32686825.
      View in: PubMed   Mentions:    Fields:    
    12. Urine Tenofovir Levels Measured by a Novel Immunoassay Predict HIV Protection. Clin Infect Dis. 2020 Jun 22. Stalter RM, Baeten JM, Donnell D, Spinelli MA, Glidden DV, Rodrigues WC, Wang G, Vincent M, Mugo N, Mujugira A, Marzinke M, Hendrix C, Gandhi M. PMID: 32569370.
      View in: PubMed   Mentions: 1     Fields:    
    13. Brief Report: High Accuracy of a Real-Time Urine Antibody-Based Tenofovir Point-of-Care Test Compared With Laboratory-Based ELISA in Diverse Populations. J Acquir Immune Defic Syndr. 2020 06 01; 84(2):149-152. Spinelli MA, Rodrigues WC, Wang G, Vincent M, Glidden DV, Okochi H, Stalter R, Defechereux P, Deutsch M, Grant RM, Ngure K, Mugo NR, Baeten JM, Gandhi M. PMID: 32167963.
      View in: PubMed   Mentions: 1     Fields:    
    14. Testing a Real-Time Tenofovir Urine Adherence Assay for Monitoring and Providing Feedback to Preexposure Prophylaxis in Kenya (PUMA): Protocol for a Pilot Randomized Controlled Trial. JMIR Res Protoc. 2020 Apr 02; 9(4):e15029. Drain P, Ngure K, Mugo N, Spinelli M, Chatterjee P, Bacchetti P, Glidden D, Baeten J, Gandhi M. PMID: 32238341.
      View in: PubMed   Mentions:
    15. Missed opportunities to prevent HIV infections among pre-exposure prophylaxis users: a population-based mixed methods study, San Francisco, United States. J Int AIDS Soc. 2020 04; 23(4):e25472. Spinelli MA, Laborde N, Kinley P, Whitacre R, Scott HM, Walker N, Liu AY, Gandhi M, Buchbinder SP. PMID: 32294338.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    16. Development and validation of the first point-of-care assay to objectively monitor adherence to HIV treatment and prevention in real-time in routine settings. AIDS. 2020 02 01; 34(2):255-260. Gandhi M, Wang G, King R, Rodrigues WC, Vincent M, Glidden DV, Cressey TR, Bacchetti P, Spinelli MA, Okochi H, Siriprakaisil O, Klinbuayaem V, Mugo NR, Ngure K, Drain PK, Baeten JM. PMID: 31634188.
      View in: PubMed   Mentions: 4     Fields:    
    17. Racial/ethnic and HIV risk category disparities in preexposure prophylaxis discontinuation among patients in publicly funded primary care clinics. AIDS. 2019 11 15; 33(14):2189-2195. Scott HM, Spinelli M, Vittinghoff E, Morehead-Gee A, Hirozawa A, James C, Hammer H, Liu A, Gandhi M, Buchbinder S. PMID: 31436610.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansPHPublic Health
    18. Homelessness at diagnosis is associated with death among people with HIV in a population-based study of a US city. AIDS. 2019 09 01; 33(11):1789-1794. Spinelli MA, Hessol NA, Schwarcz S, Hsu L, Parisi MK, Pipkin S, Scheer S, Havlir D, Buchbinder SP. PMID: 31259765.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. Impact of Estimated Pre-Exposure Prophylaxis (PrEP) Adherence Patterns on Bone Mineral Density in a Large PrEP Demonstration Project. AIDS Res Hum Retroviruses. 2019 09; 35(9):788-793. Spinelli MA, Glidden DV, Anderson PL, Gandhi M, McMahan VM, Defechereux P, Schechter M, Veloso VG, Chariyalertsak S, Guanira JV, Bekker LG, Buchbinder SP, Grant RM. PMID: 31119944.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    20. Testing a Real-Time Tenofovir Urine Adherence Assay for Monitoring and Providing Feedback to PrEP in Kenya (the PUMA study): A Pilot Randomized Clinical Trial (Preprint). JMIR Research Protocols. 2019 Jun 13. Paul Drain, Kenneth Ngure, Nelly Mugo, Matthew Spinelli, Purba Chatterjee, Peter Bacchetti, David Glidden, Jared Baeten, Monica Gandhi. .
      View in: Publisher Site   Mentions:
    21. Brief Report: Short-Term Adherence Marker to PrEP Predicts Future Nonretention in a Large PrEP Demo Project: Implications for Point-of-Care Adherence Testing. . 2019 06 01; 81(2):158-162. Spinelli MA, Glidden DV, Anderson PL, Gandhi M, Cohen S, Vittinghoff E, Coleman ME, Scott H, Bacon O, Elion R, Kolber MA, Buchbinder SP, Liu AY. PMID: 31095005.
      View in: PubMed   Mentions:
    22. Brief Report: Validation of a Urine Tenofovir Immunoassay for Adherence Monitoring to PrEP and ART and Establishing the Cutoff for a Point-of-Care Test. . 2019 05 01; 81(1):72-77. Gandhi M, Bacchetti P, Spinelli MA, Okochi H, Baeten JM, Siriprakaisil O, Klinbuayaem V, Rodrigues WC, Wang G, Vincent M, Cressey TR, Drain PK. PMID: 30664078.
      View in: PubMed   Mentions:
    23. Addressing the Sexually Transmitted Infection and HIV Syndemic. JAMA. 2019 04 09; 321(14):1356-1358. Gandhi M, Spinelli MA, Mayer KH. PMID: 30964514.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Low tenofovir level in urine by a novel immunoassay is associated with seroconversion in a preexposure prophylaxis demonstration project. AIDS. 2019 04 01; 33(5):867-872. Spinelli MA, Glidden DV, Rodrigues WC, Wang G, Vincent M, Okochi H, Kuncze K, Mehrotra M, Defechereux P, Buchbinder SP, Grant RM, Gandhi M. PMID: 30649051.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    25. High Interest in Doxycycline for Sexually Transmitted Infection Postexposure Prophylaxis in a Multicity Survey of Men Who Have Sex With Men Using a Social Networking Application. Sex Transm Dis. 2019 04; 46(4):e32-e34. Spinelli MA, Scott HM, Vittinghoff E, Liu AY, Coleman K, Buchbinder SP. PMID: 30870327.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    26. Missed Visits Associated With Future Preexposure Prophylaxis (PrEP) Discontinuation Among PrEP Users in a Municipal Primary Care Health Network. Open Forum Infect Dis. 2019 Apr; 6(4):ofz101. Spinelli MA, Scott HM, Vittinghoff E, Liu AY, Gonzalez R, Morehead-Gee A, Gandhi M, Buchbinder SP. PMID: 30949540.
      View in: PubMed   Mentions:
    27. 2272. High Interest in Doxycycline for Sexually Transmitted Infection Post-Exposure Prophylaxis (Doxy-PEP) in a Multi-city Survey of Men Having Sex With Men (MSM) Using a Social-Networking App. Open Forum Infectious Diseases. 2018 Nov 26; 5(suppl_1):s672-s673. Matthew A Spinelli, Hyman Scott, Eric Vittinghoff, Albert Y Liu, Kenneth Coleman, Monica Gandhi, Susan P Buchbinder. .
      View in: Publisher Site   Mentions:
    28. Brief Report: A Panel Management and Patient Navigation Intervention Is Associated With Earlier PrEP Initiation in a Safety-Net Primary Care Health System. . 2018 11 01; 79(3):347-351. Spinelli MA, Scott HM, Vittinghoff E, Liu AY, Morehead-Gee A, Gonzalez R, Gandhi M, Buchbinder SP. PMID: 30085955.
      View in: PubMed   Mentions:
    29. Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence. EClinicalMedicine. 2018 Aug-Sep; 2-3:22-28. Gandhi M, Bacchetti P, Rodrigues WC, Spinelli M, Koss CA, Drain PK, Baeten JM, Mugo NR, Ngure K, Benet LZ, Okochi H, Wang G, Vincent M. PMID: 30906930.
      View in: PubMed   Mentions:
    30. Provider Adherence to Pre-exposure Prophylaxis Monitoring Guidelines in a Large Primary Care Network. Open Forum Infect Dis. 2018 Jun; 5(6):ofy099. Spinelli MA, Scott HM, Vittinghoff E, Liu AY, Morehead-Gee A, Gonzalez R, Buchbinder SP. PMID: 29977959.
      View in: PubMed   Mentions:
    31. Food Insecurity is Associated with Poor HIV Outcomes Among Women in the United States. AIDS Behav. 2017 Dec; 21(12):3473-3477. Spinelli MA, Frongillo EA, Sheira LA, Palar K, Tien PC, Wilson T, Merenstein D, Cohen M, Adedimeji A, Wentz E, Adimora AA, Metsch LR, Turan JM, Kushel MB, Weiser SD. PMID: 29119474.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    32. Factors associated with substance use in older homeless adults: Results from the HOPE HOME study. Subst Abus. 2017 Jan-Mar; 38(1):88-94. PMID: 27897965.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    33. Common tasks in microscopic and ultrastructural image analysis using ImageJ. Ultrastruct Pathol. 2007 Nov-Dec; 31(6):401-7. Papadopulos F, Spinelli M, Valente S, Foroni L, Orrico C, Alviano F, Pasquinelli G. PMID: 18098058.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    34. Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. J Virol. 2007 Nov; 81(22):12582-95. Chen P, Hübner W, Spinelli MA, Chen BK. PMID: 17728240.
      View in: PubMed   Mentions: 202     Fields:    Translation:HumansCells
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