Noriyuki Kasahara, MD, PhD

Title(s)Professor, Neurological Surgery
SchoolSchool of Medicine
Address1450 Third St
San Francisco CA 94158
ORCID ORCID Icon0000-0002-6069-9082 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Tokyo Medical & Dental University, Tokyo, JapanM.B.1986Medicine
    Tokyo Medical & Dental University, Tokyo, JapanM.D.1993Endocrinology
    University of California, San Francisco (UCSF), San FranciscoResidency1993Laboratory Medicine
    University of California, San Francisco (UCSF), San FranciscoPh.D.1994Endocrinology
    Howard Hughes Medical Institute, UCSF, San FranciscoPost-Doc1995Gene Therapy
    Collapse Awards and Honors
    Tokyo Medical & Dental University1994Young Investigators Research Award
    University of California, San Francisco (UCSF)1995Chancellor Julius R. Krevans’ Distinguished Dissertation Award
    Stop Cancer Foundation1996Career Development Award
    Cooley's Anemia Foundation1998New Investigator Award
    University of California, San Francisco (UCSF) - QB32006Clinical Impact Award, Global Life Science Innovation Competition

    Collapse Overview 
    Collapse Overview
    - Development of gene therapy, oncolytic virotherapy, and immunotherapy strategies for translational application to cancer
    - Development of genetic engineering strategies for translational application to transplantation and regenerative medicine.

    Collapse Research 
    Collapse Research Activities and Funding
    GALV-Based Retroviral Replicating Vectors for Glioma Gene Therapy
    NIH R33NS104454Aug 1, 2019 - Jul 31, 2022
    Role: Principal Investigator
    GALV-Based Retroviral Replicating Vectors for Glioma Gene Therapy
    NIH R21NS104454Aug 1, 2019 - Jul 31, 2021
    Role: Principal Investigator
    Retroviral Replicating Vector-mediated Gene Therapy for Ovarian Cancer
    NIH R01CA213119Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Stem cell-based carriers for RCR vector delivery to glioblastoma
    California Institute for Regenerative Medicine (CIRM) TR2-01791Jul 1, 2011 - Jun 30, 2014
    Role: Principal Investigator
    Translational Development of Replication-Competent Retrovirus Vectors
    NIH U01NS059821Jun 1, 2010 - May 31, 2014
    Role: Principal Investigator
    Down-Regulation of Alloreactive Immune Responses to hES Cell-Derived Graft Tissues
    California Institute for Regenerative Medicine (CIRM) RS1-00402-1Oct 1, 2007 - Sep 30, 2009
    Role: Principal Investigator
    Cellular Transduction with Replication-Competent Retrovirus Vectors
    NIH R01CA121258Mar 12, 2007 - Dec 31, 2011
    Role: Principal Investigator
    Combining Virotherapy and Immunotherapy for Cancer
    NIH R01CA105171Feb 2, 2004 - Jan 31, 2010
    Role: Principal Investigator
    Cellular Trans. by Retrotransposon-Adenovirus Hybrid Ve.
    NIH R01CA093709Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator
    NIH R01CA085908Mar 1, 2000 - Feb 28, 2004
    Role: Principal Investigator
    NIH R03AR046366Sep 20, 1999 - Jul 31, 2002
    Role: Principal Investigator
    NIH R41CA081818May 10, 1999 - May 31, 2000
    Role: Principal Investigator
    NIH R21DK054280Sep 18, 1998 - Jul 31, 2000
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Collaboration Interests

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The immunogenetics of viral antigen response is associated with subtype-specific glioma risk and survival. Am J Hum Genet. 2022 06 02; 109(6):1105-1116. Guerra G, Kachuri L, Wendt G, Hansen HM, Mack SJ, Molinaro AM, Rice T, Bracci P, Wiencke JK, Kasahara N, Eckel-Passow JE, Jenkins RB, Wrensch M, Francis SS. PMID: 35550063; PMCID: PMC9247888.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Clinical development of retroviral replicating vector Toca 511 for gene therapy of cancer. Expert Opin Biol Ther. 2021 09; 21(9):1199-1214. Collins SA, Shah AH, Ostertag D, Kasahara N, Jolly DJ. PMID: 33724117; PMCID: PMC8429069.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    3. Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375. Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown CE, Chen Y, Fecci PE, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H. PMID: 33367885; PMCID: PMC7992879.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    4. Immunologic aspects of viral therapy for glioblastoma and implications for interactions with immunotherapies. J Neurooncol. 2021 Mar; 152(1):1-13. Haddad AF, Young JS, Mummaneni NV, Kasahara N, Aghi MK. PMID: 33389564; PMCID: PMC8011939.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    5. Introduction to immunotherapy for brain tumor patients: challenges and future perspectives. Neurooncol Pract. 2020 Oct; 7(5):465-476. Montoya ML, Kasahara N, Okada H. PMID: 33014387; PMCID: PMC7516091.
      View in: PubMed   Mentions: 10  
    6. Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model. Int J Mol Sci. 2020 Feb 20; 21(4). Chen SH, Sun JM, Chen BM, Lin SC, Chang HF, Collins S, Chang D, Wu SF, Lu YC, Wang W, Chen TC, Kasahara N, Wang HE, Tai CK. PMID: 32093290; PMCID: PMC7073086.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    7. A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma. Clin Cancer Res. 2019 02 15; 25(4):1379-1388. Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ. PMID: 30487124; PMCID: PMC7142219.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    8. Dual-vector prodrug activator gene therapy using retroviral replicating vectors. Cancer Gene Ther. 2019 05; 26(5-6):128-135. Kubo S, Takagi-Kimura M, Tagawa M, Kasahara N. PMID: 30348946; PMCID: PMC6760537.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC. Neuro Oncol. 2018 09 03; 20(10):1383-1392. Cloughesy TF, Landolfi J, Vogelbaum MA, Ostertag D, Elder JB, Bloomfield S, Carter B, Chen CC, Kalkanis SN, Kesari S, Lai A, Lee IY, Liau LM, Mikkelsen T, Nghiemphu P, Piccioni D, Accomando W, Diago OR, Hogan DJ, Gammon D, Kasahara N, Kheoh T, Jolly DJ, Gruber HE, Das A, Walbert T. PMID: 29762717; PMCID: PMC6120351.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCellsCTClinical Trials
    10. Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors. Cancer Gene Ther. 2019 02; 26(1-2):41-47. Kubo S, Takagi-Kimura M, Kasahara N. PMID: 30042500; PMCID: PMC6760559.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer. Cancer Gene Ther. 2018 08; 25(7-8):184-195. Inoko K, Hiraoka K, Inagaki A, Takahashi M, Kushibiki T, Hontani K, Takano H, Sato S, Takeuchi S, Nakamura T, Tsuchikawa T, Shichinohe T, Gruber HE, Jolly DJ, Kasahara N, Hirano S. PMID: 29735994.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models. Mol Ther Oncolytics. 2018 Mar 30; 8:14-26. Yagiz K, Rodriguez-Aguirre ME, Lopez Espinoza F, Montellano TT, Mendoza D, Mitchell LA, Ibanez CE, Kasahara N, Gruber HE, Jolly DJ, Robbins JM. PMID: 29322091; PMCID: PMC5751967.
      View in: PubMed   Mentions: 18  
    13. Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity. Neuro Oncol. 2017 Jul 01; 19(7):918-929. Hiraoka K, Inagaki A, Kato Y, Huang TT, Mitchell LA, Kamijima S, Takahashi M, Matsumoto H, Hacke K, Kruse CA, Ostertag D, Robbins JM, Gruber HE, Jolly DJ, Kasahara N. PMID: 28387831; PMCID: PMC5574670.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    14. Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model. Neuro Oncol. 2017 Jul 01; 19(7):930-939. Mitchell LA, Lopez Espinoza F, Mendoza D, Kato Y, Inagaki A, Hiraoka K, Kasahara N, Gruber HE, Jolly DJ, Robbins JM. PMID: 28387849; PMCID: PMC5570153.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    15. Epithelial membrane protein-2 (EMP2) promotes angiogenesis in glioblastoma multiforme. J Neurooncol. 2017 Aug; 134(1):29-40. Qin Y, Takahashi M, Sheets K, Soto H, Tsui J, Pelargos P, Antonios JP, Kasahara N, Yang I, Prins RM, Braun J, Gordon LK, Wadehra M. PMID: 28597184; PMCID: PMC5695892.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    16. Pathogens and glioma: a history of unexpected discoveries ushering in novel therapy. J Neurosurg. 2018 04; 128(4):1139-1146. Shah AH, Jusué-Torres I, Ivan ME, Komotar RJ, Kasahara N. PMID: 28598280.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. Renal Transplant Patients Biopsied for Cause and Tested for C4d, DSA, and IgG Subclasses and C1q: Which Humoral Markers Improve Diagnosis and Outcomes? J Immunol Res. 2017; 2017:1652931. Cicciarelli JC, Lemp NA, Chang Y, Koss M, Hacke K, Kasahara N, Burns KM, Min DI, Naraghi R, Shah T. PMID: 28182088; PMCID: PMC5274655.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    18. Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-γ after differentiation of glioblastoma by human natural killer cells. Cancer Immunol Immunother. 2016 09; 65(9):1085-97. Kozlowska AK, Tseng HC, Kaur K, Topchyan P, Inagaki A, Bui VT, Kasahara N, Cacalano N, Jewett A. PMID: 27439500; PMCID: PMC4996719.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    19. Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma. Sci Transl Med. 2016 06 01; 8(341):341ra75. Cloughesy TF, Landolfi J, Hogan DJ, Bloomfield S, Carter B, Chen CC, Elder JB, Kalkanis SN, Kesari S, Lai A, Lee IY, Liau LM, Mikkelsen T, Nghiemphu PL, Piccioni D, Walbert T, Chu A, Das A, Diago OR, Gammon D, Gruber HE, Hanna M, Jolly DJ, Kasahara N, McCarthy D, Mitchell L, Ostertag D, Robbins JM, Rodriguez-Aguirre M, Vogelbaum MA. PMID: 27252174; PMCID: PMC6707068.
      View in: PubMed   Mentions: 85     Fields:    Translation:CellsCTClinical Trials
    20. Factors in the Selection of Surface Disinfectants for Use in a Laboratory Animal Setting. J Am Assoc Lab Anim Sci. 2016 Mar; 55(2):175-88. Campagna MV, Faure-Kumar E, Treger JA, Cushman JD, Grogan TR, Kasahara N, Lawson GW. PMID: 27025810; PMCID: PMC4783637.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsPHPublic Health
    21. Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation Efficiency of the Downstream Transgene. Hum Gene Ther Methods. 2016 Apr; 27(2):59-70. Lin AH, Liu Y, Burrascano C, Cunanan K, Logg CR, Robbins JM, Kasahara N, Gruber H, Ibañez C, Jolly DJ. PMID: 26918465; PMCID: PMC4834527.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    22. Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells. J Cancer. 2015; 6(9):866-76. Tseng HC, Inagaki A, Bui VT, Cacalano N, Kasahara N, Man YG, Jewett A. PMID: 26284138; PMCID: PMC4532984.
      View in: PubMed   Mentions: 18  
    23. Combinatorial anti-angiogenic gene therapy in a human malignant mesothelioma model. Oncol Rep. 2015 Aug; 34(2):633-8. Kubo S, Takagi-Kimura M, Kasahara N. PMID: 26082103.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    24. Enhancement of the antigen-specific cytotoxic T lymphocyte-inducing ability in the PMDC11 leukemic plasmacytoid dendritic cell line via lentiviral vector-mediated transduction of the caTLR4 gene. Mol Med Rep. 2015 Aug; 12(2):2443-50. Iwabuchi M, Narita M, Uchiyama T, Iwaya S, Oiwa E, Nishizawa Y, Hashimoto S, Bonehill A, Kasahara N, Takizawa J, Takahashi M. PMID: 25936433; PMCID: PMC4464268.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    25. Radial mobility and cytotoxic function of retroviral replicating vector transduced, non-adherent alloresponsive T lymphocytes. J Vis Exp. 2015 Feb 11; (96). Erickson KL, Hickey MJ, Kato Y, Malone CC, Owens GC, Prins RM, Liau LM, Kasahara N, Kruse CA. PMID: 25741775; PMCID: PMC4354631.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    26. Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model. Hum Gene Ther. 2015 Feb; 26(2):82-93. Huang TT, Parab S, Burnett R, Diago O, Ostertag D, Hofman FM, Espinoza FL, Martin B, Ibañez CE, Kasahara N, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM. PMID: 25419577; PMCID: PMC4326030.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    27. Putative immunogenicity expression profiling using human pluripotent stem cells and derivatives. Stem Cells Transl Med. 2015 Feb; 4(2):136-45. Awe JP, Gschweng EH, Vega-Crespo A, Voutila J, Williamson MH, Truong B, Kohn DB, Kasahara N, Byrne JA. PMID: 25575527; PMCID: PMC4303355.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    28. Short conserved sequences of HIV-1 are highly immunogenic and shift immunodominance. J Virol. 2015 Jan 15; 89(2):1195-204. Yang OO, Ali A, Kasahara N, Faure-Kumar E, Bae JY, Picker LJ, Park H. PMID: 25378501; PMCID: PMC4300636.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    29. p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells. J Biol Chem. 2014 Dec 12; 289(50):34921-37. Veena MS, Wilken R, Zheng JY, Gholkar A, Venkatesan N, Vira D, Ahmed S, Basak SK, Dalgard CL, Ravichandran S, Batra RK, Kasahara N, Elashoff D, Fishbein MC, Whitelegge JP, Torres JZ, Wang MB, Srivatsan ES. PMID: 25331947; PMCID: PMC4263890.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    30. Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector. Cancer Gene Ther. 2014 Oct; 21(10):405-410. Takahashi M, Valdes G, Hiraoka K, Inagaki A, Kamijima S, Micewicz E, Gruber HE, Robbins JM, Jolly DJ, McBride WH, Iwamoto KS, Kasahara N. PMID: 25301172; PMCID: PMC4246057.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    31. Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids. Mol Ther Methods Clin Dev. 2014; 1:14024. Burnett R, Ibañez CE, Pettersson PL, Chen CI, Parab S, Huang T, Robbins J, Bankiewicz K, Aghi M, Logg C, Kasahara N, Pertschuk D, Gruber HE, Jolly DJ. PMID: 26015967; PMCID: PMC4362351.
      View in: PubMed   Mentions:
    32. MicroRNA 142-3p attenuates spread of replicating retroviral vector in hematopoietic lineage-derived cells while maintaining an antiviral immune response. Hum Gene Ther. 2014 Aug; 25(8):759-71. Lin AH, Timberlake N, Logg CR, Liu Y, Kamijima S, Diago O, Wong K, Gammon DK, Ostertag D, Hacke K, Yang EC, Gruber H, Kasahara N, Jolly DJ. PMID: 24825189; PMCID: PMC4137335.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    33. Mucosal gene therapy using a pseudotyped lentivirus vector encoding murine interleukin-10 (mIL-10) suppresses the development and relapse of experimental murine colitis. BMC Gastroenterol. 2014 Apr 08; 14:68. Matsumoto H, Haga K, Ohno I, Hiraoka K, Kimura T, Hermann K, Kasahara N, Anton P, McGowan I. PMID: 24712338; PMCID: PMC3991919.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    34. Epithelial membrane protein-2 (EMP2) activates Src protein and is a novel therapeutic target for glioblastoma. J Biol Chem. 2014 May 16; 289(20):13974-85. Qin Y, Fu M, Takahashi M, Iwanami A, Kuga D, Rao RG, Sudhakar D, Huang T, Kiyohara M, Torres K, Dillard C, Inagaki A, Kasahara N, Goodglick L, Braun J, Mischel PS, Gordon LK, Wadehra M. PMID: 24644285; PMCID: PMC4022868.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    35. Clinicopathological and prognostic significance of interleukin-8 expression and its relationship to KRAS mutation in lung adenocarcinoma. Br J Cancer. 2014 Apr 15; 110(8):2047-53. Sunaga N, Kaira K, Tomizawa Y, Shimizu K, Imai H, Takahashi G, Kakegawa S, Ohtaki Y, Nagashima T, Kasahara N, Kawashima O, Hisada T, Saito R, Yamada M. PMID: 24577055; PMCID: PMC3992490.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    36. Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo. Hepatology. 2014 Jan; 59(1):216-27. Reebye V, S?trom P, Mintz PJ, Huang KW, Swiderski P, Peng L, Liu C, Liu X, Lindkaer-Jensen S, Zacharoulis D, Kostomitsopoulos N, Kasahara N, Nicholls JP, Jiao LR, Pai M, Spalding DR, Mizandari M, Chikovani T, Emara MM, Haoudi A, Tomalia DA, Rossi JJ, Habib NA. PMID: 23929703; PMCID: PMC4655108.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    37. Highly efficient tumor transduction and antitumor efficacy in experimental human malignant mesothelioma using replicating gibbon ape leukemia virus. Cancer Gene Ther. 2013 Dec; 20(12):671-7. Kubo S, Takagi-Kimura M, Logg CR, Kasahara N. PMID: 24201868; PMCID: PMC8185610.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    38. Contextual effect of repression of bone morphogenetic protein activity in prostate cancer. Endocr Relat Cancer. 2013 Dec; 20(6):861-74. Pham LK, Liang M, Adisetiyo HA, Liao CP, Cohen MB, Tahara SM, Frenkel B, Kasahara N, Roy-Burman P. PMID: 24042462; PMCID: PMC3885249.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    39. Enhanced antitumor efficacy of fiber-modified, midkine promoter-regulated oncolytic adenovirus in human malignant mesothelioma. Cancer Sci. 2013 Nov; 104(11):1433-9. Takagi-Kimura M, Yamano T, Tamamoto A, Okamura N, Okamura H, Hashimoto-Tamaoki T, Tagawa M, Kasahara N, Kubo S. PMID: 23962292; PMCID: PMC7654241.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    40. Combining cellular and gene therapy approaches for treatment of intracranial tumors. Oncoimmunology. 2013 Oct 01; 2(10):e25989. Hickey MJ, Kasahara N, Mueller BM, Kruse CA. PMID: 24244896; PMCID: PMC3825732.
      View in: PubMed   Mentions:    Fields:    
    41. Exploiting human CD34+ stem cell-conditioned medium for tissue repair. Mol Ther. 2014 Jan; 22(1):149-59. Mintz PJ, Huang KW, Reebye V, Nteliopoulos G, Lai HS, Sætrom P, Kasahara N, Jensen S, Pai M, Gordon MY, Marley SB, Behan R, Spalding DR, Haoudi A, Emara MM, Nicholls J, Rossi JJ, Habib NA. PMID: 23985698; PMCID: PMC3978788.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    42. Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model. Cancer Gene Ther. 2013 Oct; 20(10):544-51. Huang TT, Hlavaty J, Ostertag D, Espinoza FL, Martin B, Petznek H, Rodriguez-Aguirre M, Ibañez CE, Kasahara N, Gunzburg W, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM. PMID: 23969884.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    43. Luminescence-based assay to screen preservation solutions for optimal ability to maintain viability of rat intestinal grafts. Transplant Proc. 2013 Jul-Aug; 45(6):2486-90. Kasahara N, Kikuchi T, Doi J, Teratani T, Fujimoto Y, Uemoto S, Yasuda Y, Kobayashi E. PMID: 23953567.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    44. Combined alloreactive CTL cellular therapy with prodrug activator gene therapy in a model of breast cancer metastatic to the brain. Clin Cancer Res. 2013 Aug 01; 19(15):4137-48. Hickey MJ, Malone CC, Erickson KL, Lin A, Soto H, Ha ET, Kamijima S, Inagaki A, Takahashi M, Kato Y, Kasahara N, Mueller BM, Kruse CA. PMID: 23780889; PMCID: PMC3939036.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    45. A Short-activating RNA Oligonucleotide Targeting the Islet �-cell Transcriptional Factor MafA in CD34(+) Cells. Mol Ther Nucleic Acids. 2013 Jun 04; 2:e97. Reebye V, S?trom P, Mintz PJ, Rossi JJ, Kasahara N, Nteliopoulos G, Nicholls J, Haoudi A, Gordon M, Habib NA. PMID: 23736775; PMCID: PMC3696904.
      View in: PubMed   Mentions: 5  
    46. Genetic modification of mouse bone marrow by lentiviral vector-mediated delivery of hypoxanthine-Guanine phosphoribosyltransferase short hairpin RNA confers chemoprotection against 6-thioguanine cytotoxicity. Transplant Proc. 2013 Jun; 45(5):2040-4. Hacke K, Treger JA, Bogan BT, Schiestl RH, Kasahara N. PMID: 23769104; PMCID: PMC4305395.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    47. Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model. Cancer Gene Ther. 2013 Jun; 20(6):336-41. Yin D, Zhai Y, Gruber HE, Ibanez CE, Robbins JM, Kells AP, Kasahara N, Forsayeth J, Jolly DJ, Bankiewicz KS. PMID: 23703472; PMCID: PMC3733370.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    48. The innovative evolution of cancer gene and cellular therapies. Cancer Gene Ther. 2013 Mar; 20(3):141-9. Lam P, Khan G, Stripecke R, Hui KM, Kasahara N, Peng KW, Guinn BA. PMID: 23370333.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    49. Reduction of HLA class I expression by ribonucleic acid interference mitigates allogenicity of human primary and Immortalized cells. Clin Transpl. 2013; 93-101. Lemp NA, Haga K, Hacke K, Treger JA, Bogan BT, Faure-Kumar E, Logg CR, Kruse CA, Cicciarelli JC, Kasahara N. PMID: 25095496.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    50. Immunoglobulin G subclass analysis of HLA donor specific antibodies in heart and renal transplant recipients. Clin Transpl. 2013; 413-22. Cicciarelli JC, Kasahara N, Lemp NA, Adamson R, Dembitsky W, Browne B, Steinberg S. PMID: 25095537.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    51. RIN3 is a negative regulator of mast cell responses to SCF. PLoS One. 2012; 7(11):e49615. Janson C, Kasahara N, Prendergast GC, Colicelli J. PMID: 23185384; PMCID: PMC3502454.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    52. Enhancement of antigen presenting ability in the leukemic plasmacytoid dendritic cell line (PMDC05) by lentiviral vector-mediated transduction of CD80 gene. Leuk Res. 2012 Dec; 36(12):1541-6. Yamahira A, Narita M, Ishii K, Jayathilake RM, Iwabuchi M, Satoh N, Uchiyama T, Taniguchi T, Hashimoto S, Kasahara N, Faure E, Bogan B, Takizawa J, Sone H, Takahashi M. PMID: 23040531.
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    53. Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells. Mol Ther Nucleic Acids. 2012 Aug 07; 1:e35. Voutila J, S?trom P, Mintz P, Sun G, Alluin J, Rossi JJ, Habib NA, Kasahara N. PMID: 23344177; PMCID: PMC3437803.
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    56. Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression. Mol Ther. 2012 09; 20(9):1689-98. Perez OD, Logg CR, Hiraoka K, Diago O, Burnett R, Inagaki A, Jolson D, Amundson K, Buckley T, Lohse D, Lin A, Burrascano C, Ibanez C, Kasahara N, Gruber HE, Jolly DJ. PMID: 22547150; PMCID: PMC3437576.
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    57. PET imaging for gene & cell therapy. Curr Gene Ther. 2012 Feb 01; 12(1):20-32. Collins SA, Hiraoka K, Inagaki A, Kasahara N, Tangney M. PMID: 22263921.
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    58. High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting. PLoS One. 2012; 7(1):e30940. Cronin M, Akin AR, Collins SA, Meganck J, Kim JB, Baban CK, Joyce SA, van Dam GM, Zhang N, van Sinderen D, O'Sullivan GC, Kasahara N, Gahan CG, Francis KP, Tangney M. PMID: 22295120; PMCID: PMC3266281.
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    59. Retroviral replicating vectors in cancer. Methods Enzymol. 2012; 507:199-228. Logg CR, Robbins JM, Jolly DJ, Gruber HE, Kasahara N. PMID: 22365776; PMCID: PMC7197216.
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    60. Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector. Neuro Oncol. 2012 Feb; 14(2):145-59. Ostertag D, Amundson KK, Lopez Espinoza F, Martin B, Buckley T, Galv?o da Silva AP, Lin AH, Valenta DT, Perez OD, Iba?ez CE, Chen CI, Pettersson PL, Burnett R, Daublebsky V, Hlavaty J, Gunzburg W, Kasahara N, Gruber HE, Jolly DJ, Robbins JM. PMID: 22070930; PMCID: PMC3266384.
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    61. The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation. Gastroenterology. 2012 Feb; 142(2):377-87.e1-5. Nitsche C, Edderkaoui M, Moore RM, Eibl G, Kasahara N, Treger J, Grippo PJ, Mayerle J, Lerch MM, Gukovskaya AS. PMID: 22044669; PMCID: PMC4545256.
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    62. Combined preconditioning and in�vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow. Exp Hematol. 2012 Jan; 40(1):3-13.e3. Hacke K, Szakmary A, Cuddihy AR, Rozengurt N, Lemp NA, Aubrecht J, Lawson GW, Rao NP, Crooks GM, Schiestl RH, Kasahara N. PMID: 22001673; PMCID: PMC4305396.
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    63. Replication-competent retrovirus vector-mediated prodrug activator gene therapy in experimental models of human malignant mesothelioma. Cancer Gene Ther. 2011 Aug; 18(8):571-8. Kawasaki Y, Tamamoto A, Takagi-Kimura M, Maeyama Y, Yamaoka N, Terada N, Okamura H, Kasahara N, Kubo S. PMID: 21660062; PMCID: PMC3159547.
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    64. Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells. Gene Ther. 2011 Aug; 18(8):750-64. Pincha M, Salguero G, Wedekind D, Sundarasetty BS, Lin A, Kasahara N, Brugman MH, Jirmo AC, Modlich U, Gutzmer R, B?sche G, Ganser A, Stripecke R. PMID: 21412283; PMCID: PMC3155152.
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    65. Adenovirus-retrovirus hybrid vectors achieve highly enhanced tumor transduction and antitumor efficacy in vivo. Mol Ther. 2011 Jan; 19(1):76-82. Kubo S, Haga K, Tamamoto A, Palmer DJ, Ng P, Okamura H, Kasahara N. PMID: 20808291; PMCID: PMC3017434.
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    66. Complete regression of human malignant mesothelioma xenografts following local injection of midkine promoter-driven oncolytic adenovirus. J Gene Med. 2010 Aug; 12(8):681-92. Kubo S, Kawasaki Y, Yamaoka N, Tagawa M, Kasahara N, Terada N, Okamura H. PMID: 20635326; PMCID: PMC2938764.
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    67. Optimization of enzyme-substrate pairing for bioluminescence imaging of gene transfer using Renilla and Gaussia luciferases. J Gene Med. 2010 Jun; 12(6):528-37. Kimura T, Hiraoka K, Kasahara N, Logg CR. PMID: 20527045; PMCID: PMC2989363.
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    68. Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene. Cancer Gene Ther. 2010 Sep; 17(9):614-23. Tai CK, Wang W, Lai YH, Logg CR, Parker WB, Li YF, Hong JS, Sorscher EJ, Chen TC, Kasahara N. PMID: 20467451; PMCID: PMC2938767.
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    69. Effective in vivo and ex vivo gene transfer to intestinal mucosa by VSV-G-pseudotyped lentiviral vectors. BMC Gastroenterol. 2010 May 11; 10:44. Matsumoto H, Kimura T, Haga K, Kasahara N, Anton P, McGowan I. PMID: 20459837; PMCID: PMC2881878.
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    70. International Society for Cell and Gene Therapy of Cancer 2009 Annual Meeting held in Cork, Ireland. Hum Gene Ther. 2010 Jan; 21(1):9-26. Guinn B, Casey G, M?ller MG, Kasahara N, O'Sullivan GC, Peng KW, Tangney M. PMID: 20017714.
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    71. In vivo stable transduction of humanized liver tissue in chimeric mice via high-capacity adenovirus-lentivirus hybrid vector. Hum Gene Ther. 2010 Jan; 21(1):40-50. Kubo S, Kataoka M, Tateno C, Yoshizato K, Kawasaki Y, Kimura T, Faure-Kumar E, Palmer DJ, Ng P, Okamura H, Kasahara N. PMID: 19725756; PMCID: PMC2829460.
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    72. Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation. Immunol Res. 2009; 44(1-3):112-26. Hacke K, Falahati R, Flebbe-Rehwaldt L, Kasahara N, Gaensler KM. PMID: 19048410; PMCID: PMC2938774.
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    73. ASSOCIATION BETWEEN DE NOVO DONOR SPECIFIC HLA ANTIBODY, C4D STAINING IN RENAL GRAFT BIOPSY AND GRAFT OUTCOME: A SINGLE CENTER EXPERIENCE. J Nephrol Ren Transplant. 2009; 2(2):69-74. Cicciarelli J, Cho YW, Koss M, Helstab-Houston K, Mendez R, Kasahara N, Hutchinson IV, Shah T. PMID: 22514590; PMCID: PMC3327131.
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    75. Splicing mediates the activity of four putative cellular internal ribosome entry sites. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4733-8. Baranick BT, Lemp NA, Nagashima J, Hiraoka K, Kasahara N, Logg CR. PMID: 18326627; PMCID: PMC2290820.
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    76. Replication-competent retrovirus vectors for cancer gene therapy. Front Biosci. 2008 Jan 01; 13:3083-95. Tai CK, Kasahara N. PMID: 17981778.
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    77. CREB is a critical regulator of normal hematopoiesis and leukemogenesis. Blood. 2008 Feb 01; 111(3):1182-92. Cheng JC, Kinjo K, Judelson DR, Chang J, Wu WS, Schmid I, Shankar DB, Kasahara N, Stripecke R, Bhatia R, Landaw EM, Sakamoto KM. PMID: 17975014; PMCID: PMC2214769.
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    78. Highly efficient gene delivery for bladder cancers by intravesically administered replication-competent retroviral vectors. Clin Cancer Res. 2007 Aug 01; 13(15 Pt 1):4511-8. Kikuchi E, Menendez S, Ozu C, Ohori M, Cordon-Cardo C, Logg CR, Kasahara N, Bochner BH. PMID: 17671137.
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    79. Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model. Cancer Res. 2007 Jun 01; 67(11):5345-53. Hiraoka K, Kimura T, Logg CR, Tai CK, Haga K, Lawson GW, Kasahara N. PMID: 17545615; PMCID: PMC8207455.
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    80. Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression. Mol Ther. 2007 Jul; 15(7):1390-9. Kimura T, Koya RC, Anselmi L, Sternini C, Wang HJ, Comin-Anduix B, Prins RM, Faure-Kumar E, Rozengurt N, Cui Y, Kasahara N, Stripecke R. PMID: 17505480.
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    81. Adaptive evolution of a tagged chimeric gammaretrovirus: identification of novel cis-acting elements that modulate splicing. J Mol Biol. 2007 Jun 22; 369(5):1214-29. Logg CR, Baranick BT, Lemp NA, Kasahara N. PMID: 17498744; PMCID: PMC2938735.
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    82. Recent advances and current challenges in tumor immunology and immunotherapy. Mol Ther. 2007 Jun; 15(6):1065-71. Guinn BA, Kasahara N, Farzaneh F, Habib NA, Norris JS, Deisseroth AB. PMID: 17375068.
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    83. Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines. Mol Ther. 2007 May; 15(5):971-80. Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R. PMID: 17375074.
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    84. Replication-competent vectors and empty virus-like particles: new retroviral vector designs for cancer gene therapy or vaccines. Mol Ther. 2007 Mar; 15(3):457-66. Dalba C, Bellier B, Kasahara N, Klatzmann D. PMID: 17245356.
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    85. Delivery of replication-competent retrovirus expressing Escherichia coli purine nucleoside phosphorylase increases the metabolism of the prodrug, fludarabine phosphate and suppresses the growth of bladder tumor xenografts. Cancer Gene Ther. 2007 Mar; 14(3):279-86. Kikuchi E, Menendez S, Ozu C, Ohori M, Cordon-Cardo C, Logg CR, Kasahara N, Bochner BH. PMID: 17218950.
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    86. Lentiviral vector-mediated gene transfer to endotherial cells compared with adenoviral and retroviral vectors. Prep Biochem Biotechnol. 2007; 37(1):1-11. Sakoda T, Kasahara N, Kedes L, Ohyanagi M. PMID: 17134978.
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    87. Adenoviral receptor expression of normal bladder and transitional cell carcinoma of the bladder. Urol Int. 2007; 78(2):160-6. Buscarini M, Quek ML, Gilliam-Hegarich S, Kasahara N, Bochner B. PMID: 17293658.
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    88. Calcium phosphate coprecipitation greatly enhances transduction of cardiac myocytes and vascular smooth muscle cells by lentivirus vectors. Exp Clin Cardiol. 2007; 12(3):133-8. Sakoda T, Kasahara N, Kedes L, Ohyanagi M. PMID: 18650994; PMCID: PMC2323759.
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    89. Tumor-selective gene expression in a hepatic metastasis model after locoregional delivery of a replication-competent retrovirus vector. Clin Cancer Res. 2006 Dec 01; 12(23):7108-16. Hiraoka K, Kimura T, Logg CR, Kasahara N. PMID: 17145835; PMCID: PMC8207453.
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    90. Permanent, lowered HLA class I expression using lentivirus vectors with shRNA constructs: Averting cytotoxicity by alloreactive T lymphocytes. Transplant Proc. 2006 Dec; 38(10):3184-8. Haga K, Lemp NA, Logg CR, Nagashima J, Faure-Kumar E, Gomez GG, Kruse CA, Mendez R, Stripecke R, Kasahara N, Kasahara NA, Cicciarelli JC. PMID: 17175217; PMCID: PMC1868890.
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    91. The strange case of TGN1412. Cancer Immunol Immunother. 2007 Feb; 56(2):129-34. Farzaneh L, Kasahara N, Farzaneh F. PMID: 16783575.
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    92. International Society for Cell and Gene Therapy of Cancer (ISCGT) annual meeting: conference overview and introduction to the symposium papers. Cancer Immunol Immunother. 2006 Nov; 55(11):1406-11. Guinn BA, Norris JS, Huang L, Farzaneh F, Kasahara N, Deisseroth AB. PMID: 16783577.
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    93. Transcriptional targeting of adenovirus vectors with the squamous cell carcinoma-specific antigen-2 promoter for selective apoptosis induction in lung cancer. Cancer Gene Ther. 2006 Sep; 13(9):856-63. Oshikiri T, Miyamoto M, Hiraoka K, Shichinohe T, Kawarada Y, Kato K, Suzuoki M, Nakakubo Y, Kondo S, Dosaka-Akita H, Kasahara N, Katoh H. PMID: 16710347.
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    94. L1 retrotransposition in nondividing and primary human somatic cells. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8036-41. Kubo S, Seleme MC, Soifer HS, Perez JL, Moran JV, Kazazian HH, Kasahara N. PMID: 16698926; PMCID: PMC1472425.
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    95. Use of replication-competent retroviral vectors in an immunocompetent intracranial glioma model. Neurosurg Focus. 2006 Apr 15; 20(4):E25. Wang W, Tai CK, Kershaw AD, Solly SK, Klatzmann D, Kasahara N, Chen TC. PMID: 16709031; PMCID: PMC8295718.
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    96. Beyond oncolytic virotherapy: replication-competent retrovirus vectors for selective and stable transduction of tumors. Curr Gene Ther. 2005 Dec; 5(6):655-67. Dalba C, Klatzmann D, Logg CR, Kasahara N. PMID: 16457654.
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    97. Retargeting of adenoviral vector using basic fibroblast growth factor ligand for malignant glioma gene therapy. J Neurosurg. 2005 Dec; 103(6):1058-66. Wang W, Zhu NL, Chua J, Swenson S, Costa FK, Schmitmeier S, Sosnowski BA, Shichinohe T, Kasahara N, Chen TC. PMID: 16381193.
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    98. Single-shot, multicycle suicide gene therapy by replication-competent retrovirus vectors achieves long-term survival benefit in experimental glioma. Mol Ther. 2005 Nov; 12(5):842-51. Tai CK, Wang WJ, Chen TC, Kasahara N. PMID: 16257382; PMCID: PMC8185609.
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    99. Retrotransposon-adenovirus hybrid vectors: efficient delivery and stable integration of transgenes via a two-stage mechanism. Curr Gene Ther. 2004 Dec; 4(4):373-84. Soifer HS, Kasahara N. PMID: 15578988.
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    100. Development of packaging cell lines for generation of adeno-associated virus vectors by lentiviral gene transfer of trans-complementary components. Eur J Haematol. 2004 Oct; 73(4):285-94. Nakamura S, Nakamura R, Shibata K, Kobayashi M, Sahara N, Shigeno K, Shinjo K, Naito K, Ohnishi K, Kasahara N, Iwaki Y. PMID: 15347316.
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    101. Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo. Mol Ther. 2004 Aug; 10(2):318-26. Woodley DT, Keene DR, Atha T, Huang Y, Ram R, Kasahara N, Chen M. PMID: 15294178.
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    102. Making dendritic cells from the inside out: lentiviral vector-mediated gene delivery of granulocyte-macrophage colony-stimulating factor and interleukin 4 into CD14+ monocytes generates dendritic cells in vitro. Hum Gene Ther. 2004 Aug; 15(8):733-48. Koya RC, Weber JS, Kasahara N, Lau R, Villacres MC, Levine AM, Stripecke R. PMID: 15319031.
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    103. Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland. Gene Ther. 2004 Jun; 11(12):970-81. Wang Y, Xie J, Yarber FA, Mazurek C, Trousdale MD, Medina-Kauwe LK, Kasahara N, Hamm-Alvarez SF. PMID: 15029229.
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    104. Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer. Hum Gene Ther. 2004 May; 15(5):457-68. Qiao R, Zhou B, Harboe-Schmidt E, Kasahara N, Kim KJ, Liebler JM, Crandall ED, Borok Z. PMID: 15144576.
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    105. Inhibition of orthotopic human bladder tumor growth by lentiviral gene transfer of endostatin. Clin Cancer Res. 2004 Mar 01; 10(5):1835-42. Kikuchi E, Menendez S, Ohori M, Cordon-Cardo C, Kasahara N, Bochner BH. PMID: 15014038.
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    106. Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. J Biol Chem. 2004 Apr 02; 279(14):13659-67. Li B, Navarro S, Kasahara N, Comai L. PMID: 14734561.
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    107. Retrovirus-mediated gene transfer to tumors: utilizing the replicative power of viruses to achieve highly efficient tumor transduction in vivo. Methods Mol Biol. 2004; 246:499-525. Logg CR, Kasahara N. PMID: 14970613.
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    108. Potent maturation of monocyte-derived dendritic cells after CD40L lentiviral gene delivery. J Immunother. 2003 Sep-Oct; 26(5):451-60. Koya RC, Kasahara N, Favaro PM, Lau R, Ta HQ, Weber JS, Stripecke R. PMID: 12973034.
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    109. The use of lentiviral vectors in gene therapy of leukemia: combinatorial gene delivery of immunomodulators into leukemia cells by state-of-the-art vectors. Blood Cells Mol Dis. 2003 Jul-Aug; 31(1):28-37. Stripecke R, Koya RC, Ta HQ, Kasahara N, Levine AM. PMID: 12850480.
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    110. Antibody-mediated targeting of replication-competent retroviral vectors. Hum Gene Ther. 2003 May 20; 14(8):789-802. Tai CK, Logg CR, Park JM, Anderson WF, Press MF, Kasahara N. PMID: 12804141.
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    111. Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells. J Cell Sci. 2003 May 15; 116(Pt 10):2051-65. Wang Y, Jerdeva G, Yarber FA, da Costa SR, Xie J, Qian L, Rose CM, Mazurek C, Kasahara N, Mircheff AK, Hamm-Alvarez SF. PMID: 12679381.
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    112. An efficient gene transduction system for studying gene function in primary human dermal fibroblasts and epidermal keratinocytes. Clin Exp Dermatol. 2003 Mar; 28(2):193-9. Chen M, Li W, Fan J, Kasahara N, Woodley D. PMID: 12653712.
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    113. Highly efficient and tumor-restricted gene transfer to malignant gliomas by replication-competent retroviral vectors. Hum Gene Ther. 2003 Jan 20; 14(2):117-27. Wang WJ, Tai CK, Kasahara N, Chen TC. PMID: 12614563; PMCID: PMC8295717.
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    114. Lentivirus vector-mediated gene transfer to cardiomyocytes. Methods Mol Biol. 2003; 219:53-70. Sakoda T, Kasahara N, Kedes L. PMID: 12596998.
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    115. Tissue-specific transcriptional targeting of a replication-competent retroviral vector. J Virol. 2002 Dec; 76(24):12783-91. Logg CR, Logg A, Matusik RJ, Bochner BH, Kasahara N. PMID: 12438603; PMCID: PMC136666.
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    116. Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Nat Genet. 2002 Dec; 32(4):670-5. Chen M, Kasahara N, Keene DR, Chan L, Hoeffler WK, Finlay D, Barcova M, Cannon PM, Mazurek C, Woodley DT. PMID: 12426566.
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    117. Transduction of acute myeloid leukemia cells with third generation self-inactivating lentiviral vectors expressing CD80 and GM-CSF: effects on proliferation, differentiation, and stimulation of allogeneic and autologous anti-leukemia immune responses. Leukemia. 2002 Sep; 16(9):1645-54. Koya RC, Kasahara N, Pullarkat V, Levine AM, Stripecke R. PMID: 12200676.
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    118. High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker. Int J Cancer. 2002 May 20; 99(3):418-23. Hiraoka K, Hida Y, Miyamoto M, Oshikiri T, Suzuoki M, Nakakubo Y, Shinohara T, Itoh T, Shichinohe T, Kondo S, Kasahara N, Katoh H. PMID: 11992411.
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    119. A novel, helper-dependent, adenovirus-retrovirus hybrid vector: stable transduction by a two-stage mechanism. Mol Ther. 2002 May; 5(5 Pt 1):599-608. Soifer H, Higo C, Logg CR, Jih LJ, Shichinohe T, Harboe-Schmidt E, Mitani K, Kasahara N. PMID: 11991751.
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    120. An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen. Exp Cell Res. 2002 Feb 15; 273(2):219-28. Li W, Nadelman C, Gratch NS, Li W, Chen M, Kasahara N, Woodley DT. PMID: 11822877.
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    121. Vesicular stomatitis virus G-pseudotyped lentivirus vectors mediate efficient apical transduction of polarized quiescent primary alveolar epithelial cells. J Virol. 2001 Dec; 75(23):11747-54. Borok Z, Harboe-Schmidt JE, Brody SL, You Y, Zhou B, Li X, Cannon PM, Kim KJ, Crandall ED, Kasahara N. PMID: 11689655; PMCID: PMC114760.
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    122. Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins. Gene Ther. 2001 Dec; 8(23):1753-61. Medina-Kauwe LK, Maguire M, Kasahara N, Kedes L. PMID: 11803394.
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    123. Development of lentiviral vectors for antiangiogenic gene delivery. Cancer Gene Ther. 2001 Nov; 8(11):879-89. Shichinohe T, Bochner BH, Mizutani K, Nishida M, Hegerich-Gilliam S, Naldini L, Kasahara N. PMID: 11773978.
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    124. Recent advances in retrovirus vector-mediated gene therapy: teaching an old vector new tricks. Curr Opin Mol Ther. 2001 Oct; 3(5):439-53. Weber E, Anderson WF, Kasahara N. PMID: 11699888.
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    125. A replication-competent feline leukemia virus, subgroup A (FeLV-A), tagged with green fluorescent protein reporter exhibits in vitro biological properties similar to those of the parental FeLV-A. J Virol. 2001 Sep; 75(18):8837-41. Chang Z, Pan J, Logg C, Kasahara N, Roy-Burman P. PMID: 11507228; PMCID: PMC115128.
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    126. Genomic stability of murine leukemia viruses containing insertions at the Env-3' untranslated region boundary. J Virol. 2001 Aug; 75(15):6989-98. Logg CR, Logg A, Tai CK, Cannon PM, Kasahara N. PMID: 11435579; PMCID: PMC114427.
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    127. Selectively replicating adenoviruses for oncolytic therapy. Curr Cancer Drug Targets. 2001 Aug; 1(2):85-107. Yoon TK, Shichinohe T, Laquerre S, Kasahara N. PMID: 12188883.
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    128. Stable integration of transgenes delivered by a retrotransposon-adenovirus hybrid vector. Hum Gene Ther. 2001 Jul 20; 12(11):1417-28. Soifer H, Higo C, Kazazian HH, Moran JV, Mitani K, Kasahara N. PMID: 11485633.
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    129. A uniquely stable replication-competent retrovirus vector achieves efficient gene delivery in vitro and in solid tumors. Hum Gene Ther. 2001 May 20; 12(8):921-32. Logg CR, Tai CK, Logg A, Anderson WF, Kasahara N. PMID: 11387057; PMCID: PMC8184367.
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    130. 3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins. Gene Ther. 2001 May; 8(10):795-803. Medina-Kauwe LK, Kasahara N, Kedes L. PMID: 11420644.
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    131. Receptor-specific targeting mediated by the coexpression of a targeted murine leukemia virus envelope protein and a binding-defective influenza hemagglutinin protein. Hum Gene Ther. 2001 Mar 01; 12(4):323-32. Lin AH, Kasahara N, Wu W, Stripecke R, Empig CL, Anderson WF, Cannon PM. PMID: 11242525.
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    132. The effect of fibroblast growth factor 8, isoform b, on the biology of prostate carcinoma cells and their interaction with stromal cells. Cancer Res. 2000 Dec 01; 60(23):6730-6. Song Z, Powell WC, Kasahara N, van Bokhoven A, Miller GJ, Roy-Burman P. PMID: 11118059.
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    133. Development and characterization of a recombinant truncated type VII collagen "minigene". Implication for gene therapy of dystrophic epidermolysis bullosa. J Biol Chem. 2000 Aug 11; 275(32):24429-35. Chen M, O'Toole EA, Muellenhoff M, Medina E, Kasahara N, Woodley DT. PMID: 10821839.
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    134. Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes. J Biol Chem. 2000 Jun 30; 275(26):19992-20001. Smith E, Redman RA, Logg CR, Coetzee GA, Kasahara N, Frenkel B. PMID: 10867026.
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    135. Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. J Biol Chem. 2000 Apr 07; 275(14):10405-12. Mohan R, Sivak J, Ashton P, Russo LA, Pham BQ, Kasahara N, Raizman MB, Fini ME. PMID: 10744729.
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    136. A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes. J Mol Cell Cardiol. 1999 Nov; 31(11):2037-47. Sakoda T, Kasahara N, Hamamori Y, Kedes L. PMID: 10591030.
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    137. DNA sequence comparison considering both amino acid and nucleotide insertions/deletions because of evolution and experimental error. J Biotechnol. 1999 Mar 26; 69(1):19-26. Irie R, Hiraoka S, Kasahara N, Nagai K. PMID: 10201112.
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    138. Corneal incision phacoemulsification and internal bleb revision. Ophthalmic Surg Lasers. 1996 May; 27(5):361-6. Kasahara N, Sibayan SA, Montenegro MH, Simmons RB, Smith TJ. PMID: 8860602.
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    139. Ligand-directed retroviral targeting of human breast cancer cells. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9747-51. Han X, Kasahara N, Kan YW. PMID: 7568210; PMCID: PMC40879.
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    140. Protein tyrosine kinases expressed in glomeruli and cultured glomerular cells: Flt-1 and VEGF expression in renal mesangial cells. Biochem Biophys Res Commun. 1995 Apr 06; 209(1):218-26. Takahashi T, Shirasawa T, Miyake K, Yahagi Y, Maruyama N, Kasahara N, Kawamura T, Matsumura O, Mitarai T, Sakai O. PMID: 7726838.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    141. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. Science. 1994 Nov 25; 266(5189):1373-6. Kasahara N, Dozy AM, Kan YW. PMID: 7973726.
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    142. Suppression of mammary tumors by oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice. Anticancer Drugs. 1993 Dec; 4(6):651-5. Sakamoto S, Mizuno M, Kudo H, Suzuki S, Kasahara N, Sugiura Y, Mori T, Nagasawa H. PMID: 8298164.
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    143. Deletional analysis of the human renin promoter: transcriptional activation by the SV40 enhancer enables identification of promoter regulatory elements in non-renin-expressing cells. Bull Tokyo Med Dent Univ. 1993 Jun; 40(2):79-91. Kasahara N. PMID: 8390924.
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    144. Effects of luteinizing hormone-releasing hormone analogue on DNA synthesis in rat prostate and uterus. In Vivo. 1993 Jan-Feb; 7(1):13-6. Sakamoto S, Tajima M, Sawaki K, Suzuki S, Kudo H, Sassa S, Kuwa K, Sugiura Y, Kasahara N, Nagasawa H. PMID: 8504203.
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    145. Suppression by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice. Anticancer Res. 1992 Jul-Aug; 12(4):1291-4. Sakamoto S, Mizuno M, Sawaki K, Kudo H, Kasahara N, Suzuki S, Mori T, Nagasawa H. PMID: 1503423.
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    146. Inhibition by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene in rats. Anticancer Res. 1991 Mar-Apr; 11(2):561-6. Sakamoto S, Hirai H, Taga H, Uchikoshi T, Sunaga T, Endo Y, Kudo H, Kato T, Kasahara N, Kuwa K, et al. PMID: 1712176.
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    147. [Thymidine kinase activities in sera and liver tissues during hepatocarcinogenesis in rats treated with 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB)]. Nihon Gan Chiryo Gakkai Shi. 1990 Dec 20; 25(12):2794-801. Sakamoto S, Kuwa K, Kawachi Y, Kudo H, Kasahara N, Kato T, Okamoto R, Taga H, Hirai H, Sunaga T, et al. PMID: 2074389.
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    148. Thymidine kinase and alpha-fetoprotein as biochemical markers of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene treatment in rats. Carcinogenesis. 1990 Jan; 11(1):145-50. Sakamoto S, Hirai H, Taga H, Uchikoshi T, Sunaga T, Endo Y, Kuwa K, Kudo H, Kawachi Y, Kasahara N, et al. PMID: 1688518.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
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