Loading...

Noriyuki Kasahara, MD, PhD

Title(s)Professor, Neurological Surgery
SchoolSchool of Medicine
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    GALV-Based Retroviral Replicating Vectors for Glioma Gene Therapy
    NIH/NINDS R21NS104454Aug 1, 2019 - Jul 31, 2020
    Role: Principal Investigator
    Retroviral Replicating Vector-mediated Gene Therapy for Ovarian Cancer
    NIH/NCI R01CA213119Aug 1, 2017 - Jul 31, 2022
    Role: Principal Investigator
    Translational Development of Replication-Competent Retrovirus Vectors
    NIH/NINDS U01NS059821Jun 1, 2010 - May 31, 2014
    Role: Principal Investigator
    Cellular Transduction with Replication-Competent Retrovirus Vectors
    NIH/NCI R01CA121258Mar 12, 2007 - Dec 31, 2011
    Role: Principal Investigator
    Combining Virotherapy and Immunotherapy for Cancer
    NIH/NCI R01CA105171Feb 2, 2004 - Jan 31, 2010
    Role: Principal Investigator
    Cellular Trans. by Retrotransposon-Adenovirus Hybrid Ve.
    NIH/NCI R01CA093709Jul 1, 2002 - Jun 30, 2007
    Role: Principal Investigator
    TRANSCRIPTIONAL TARGETING OF RETROVIRAL REPLICATION
    NIH/NCI R01CA085908Mar 1, 2000 - Feb 28, 2004
    Role: Principal Investigator
    ANTI-ANGIOGENIC GENE THERAPY FOR RHEUMATOID ARTHRITIS
    NIH/NIAMS R03AR046366Sep 20, 1999 - Jul 31, 2002
    Role: Principal Investigator
    DEVELOPMENT OF ADENOVIRAL PROTEIN/DNA CONJUGATE VECTORS
    NIH/NCI R41CA081818May 10, 1999 - May 31, 2000
    Role: Principal Investigator
    NOVEL ADENOVIRUS-RETROELEMENT HYBRID VECTORS
    NIH/NIDDK R21DK054280Sep 18, 1998 - Jul 31, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ. A CK1a Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma. Clin Cancer Res. 2019 Feb 15; 25(4):1379-1388. PMID: 30487124.
      View in: PubMed
    2. Kubo S, Takagi-Kimura M, Tagawa M, Kasahara N. Dual-vector prodrug activator gene therapy using retroviral replicating vectors. Cancer Gene Ther. 2018 Oct 22. PMID: 30348946.
      View in: PubMed
    3. Cloughesy TF, Landolfi J, Vogelbaum MA, Ostertag D, Elder JB, Bloomfield S, Carter B, Chen CC, Kalkanis SN, Kesari S, Lai A, Lee IY, Liau LM, Mikkelsen T, Nghiemphu P, Piccioni D, Accomando W, Diago OR, Hogan DJ, Gammon D, Kasahara N, Kheoh T, Jolly DJ, Gruber HE, Das A, Walbert T. Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC. Neuro Oncol. 2018 Sep 03; 20(10):1383-1392. PMID: 29762717.
      View in: PubMed
    4. Kubo S, Takagi-Kimura M, Kasahara N. Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors. Cancer Gene Ther. 2019 Feb; 26(1-2):41-47. PMID: 30042500.
      View in: PubMed
    5. Inoko K, Hiraoka K, Inagaki A, Takahashi M, Kushibiki T, Hontani K, Takano H, Sato S, Takeuchi S, Nakamura T, Tsuchikawa T, Shichinohe T, Gruber HE, Jolly DJ, Kasahara N, Hirano S. Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer. Cancer Gene Ther. 2018 08; 25(7-8):184-195. PMID: 29735994.
      View in: PubMed
    6. Yagiz K, Rodriguez-Aguirre ME, Lopez Espinoza F, Montellano TT, Mendoza D, Mitchell LA, Ibanez CE, Kasahara N, Gruber HE, Jolly DJ, Robbins JM. A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models. Mol Ther Oncolytics. 2018 Mar 30; 8:14-26. PMID: 29322091.
      View in: PubMed
    7. Hiraoka K, Inagaki A, Kato Y, Huang TT, Mitchell LA, Kamijima S, Takahashi M, Matsumoto H, Hacke K, Kruse CA, Ostertag D, Robbins JM, Gruber HE, Jolly DJ, Kasahara N. Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity. Neuro Oncol. 2017 Jul 01; 19(7):918-929. PMID: 28387831.
      View in: PubMed
    8. Mitchell LA, Lopez Espinoza F, Mendoza D, Kato Y, Inagaki A, Hiraoka K, Kasahara N, Gruber HE, Jolly DJ, Robbins JM. Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model. Neuro Oncol. 2017 Jul 01; 19(7):930-939. PMID: 28387849.
      View in: PubMed
    9. Qin Y, Takahashi M, Sheets K, Soto H, Tsui J, Pelargos P, Antonios JP, Kasahara N, Yang I, Prins RM, Braun J, Gordon LK, Wadehra M. Epithelial membrane protein-2 (EMP2) promotes angiogenesis in glioblastoma multiforme. J Neurooncol. 2017 Aug; 134(1):29-40. PMID: 28597184.
      View in: PubMed
    10. Shah AH, Jusué-Torres I, Ivan ME, Komotar RJ, Kasahara N. Pathogens and glioma: a history of unexpected discoveries ushering in novel therapy. J Neurosurg. 2018 Apr; 128(4):1139-1146. PMID: 28598280.
      View in: PubMed
    11. Cicciarelli JC, Lemp NA, Chang Y, Koss M, Hacke K, Kasahara N, Burns KM, Min DI, Naraghi R, Shah T. Renal Transplant Patients Biopsied for Cause and Tested for C4d, DSA, and IgG Subclasses and C1q: Which Humoral Markers Improve Diagnosis and Outcomes? J Immunol Res. 2017; 2017:1652931. PMID: 28182088.
      View in: PubMed
    12. Kozlowska AK, Tseng HC, Kaur K, Topchyan P, Inagaki A, Bui VT, Kasahara N, Cacalano N, Jewett A. Resistance to cytotoxicity and sustained release of interleukin-6 and interleukin-8 in the presence of decreased interferon-? after differentiation of glioblastoma by human natural killer cells. Cancer Immunol Immunother. 2016 09; 65(9):1085-97. PMID: 27439500.
      View in: PubMed
    13. Cloughesy TF, Landolfi J, Hogan DJ, Bloomfield S, Carter B, Chen CC, Elder JB, Kalkanis SN, Kesari S, Lai A, Lee IY, Liau LM, Mikkelsen T, Nghiemphu PL, Piccioni D, Walbert T, Chu A, Das A, Diago OR, Gammon D, Gruber HE, Hanna M, Jolly DJ, Kasahara N, McCarthy D, Mitchell L, Ostertag D, Robbins JM, Rodriguez-Aguirre M, Vogelbaum MA. Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma. Sci Transl Med. 2016 06 01; 8(341):341ra75. PMID: 27252174.
      View in: PubMed
    14. Campagna MV, Faure-Kumar E, Treger JA, Cushman JD, Grogan TR, Kasahara N, Lawson GW. Factors in the Selection of Surface Disinfectants for Use in a Laboratory Animal Setting. J Am Assoc Lab Anim Sci. 2016 Mar; 55(2):175-88. PMID: 27025810.
      View in: PubMed
    15. Lin AH, Liu Y, Burrascano C, Cunanan K, Logg CR, Robbins JM, Kasahara N, Gruber H, Ibañez C, Jolly DJ. Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation Efficiency of the Downstream Transgene. Hum Gene Ther Methods. 2016 Apr; 27(2):59-70. PMID: 26918465.
      View in: PubMed
    16. Tseng HC, Inagaki A, Bui VT, Cacalano N, Kasahara N, Man YG, Jewett A. Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells. J Cancer. 2015; 6(9):866-76. PMID: 26284138; PMCID: PMC4532984.
    17. Kubo S, Takagi-Kimura M, Kasahara N. Combinatorial anti-angiogenic gene therapy in a human malignant mesothelioma model. Oncol Rep. 2015 Aug; 34(2):633-8. PMID: 26082103.
      View in: PubMed
    18. Iwabuchi M, Narita M, Uchiyama T, Iwaya S, Oiwa E, Nishizawa Y, Hashimoto S, Bonehill A, Kasahara N, Takizawa J, Takahashi M. Enhancement of the antigen-specific cytotoxic T lymphocyte-inducing ability in the PMDC11 leukemic plasmacytoid dendritic cell line via lentiviral vector-mediated transduction of the caTLR4 gene. Mol Med Rep. 2015 Aug; 12(2):2443-50. PMID: 25936433.
      View in: PubMed
    19. Erickson KL, Hickey MJ, Kato Y, Malone CC, Owens GC, Prins RM, Liau LM, Kasahara N, Kruse CA. Radial mobility and cytotoxic function of retroviral replicating vector transduced, non-adherent alloresponsive T lymphocytes. J Vis Exp. 2015 Feb 11; (96). PMID: 25741775.
      View in: PubMed
    20. Huang TT, Parab S, Burnett R, Diago O, Ostertag D, Hofman FM, Espinoza FL, Martin B, Ibañez CE, Kasahara N, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM. Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model. Hum Gene Ther. 2015 Feb; 26(2):82-93. PMID: 25419577.
      View in: PubMed
    21. Awe JP, Gschweng EH, Vega-Crespo A, Voutila J, Williamson MH, Truong B, Kohn DB, Kasahara N, Byrne JA. Putative immunogenicity expression profiling using human pluripotent stem cells and derivatives. Stem Cells Transl Med. 2015 Feb; 4(2):136-45. PMID: 25575527.
      View in: PubMed
    22. Yang OO, Ali A, Kasahara N, Faure-Kumar E, Bae JY, Picker LJ, Park H. Short conserved sequences of HIV-1 are highly immunogenic and shift immunodominance. J Virol. 2015 Jan 15; 89(2):1195-204. PMID: 25378501.
      View in: PubMed
    23. Veena MS, Wilken R, Zheng JY, Gholkar A, Venkatesan N, Vira D, Ahmed S, Basak SK, Dalgard CL, Ravichandran S, Batra RK, Kasahara N, Elashoff D, Fishbein MC, Whitelegge JP, Torres JZ, Wang MB, Srivatsan ES. p16 Protein and gigaxonin are associated with the ubiquitination of NF?B in cisplatin-induced senescence of cancer cells. J Biol Chem. 2014 Dec 12; 289(50):34921-37. PMID: 25331947; PMCID: PMC4263890.
    24. Takahashi M, Valdes G, Hiraoka K, Inagaki A, Kamijima S, Micewicz E, Gruber HE, Robbins JM, Jolly DJ, McBride WH, Iwamoto KS, Kasahara N. Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector. Cancer Gene Ther. 2014 Oct; 21(10):405-410. PMID: 25301172.
      View in: PubMed
    25. Burnett R, Ibañez CE, Pettersson PL, Chen CI, Parab S, Huang T, Robbins J, Bankiewicz K, Aghi M, Logg C, Kasahara N, Pertschuk D, Gruber HE, Jolly DJ. Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids. Mol Ther Methods Clin Dev. 2014; 1:14024. PMID: 26015967; PMCID: PMC4362351.
    26. Lin AH, Timberlake N, Logg CR, Liu Y, Kamijima S, Diago O, Wong K, Gammon DK, Ostertag D, Hacke K, Yang EC, Gruber H, Kasahara N, Jolly DJ. MicroRNA 142-3p attenuates spread of replicating retroviral vector in hematopoietic lineage-derived cells while maintaining an antiviral immune response. Hum Gene Ther. 2014 Aug; 25(8):759-71. PMID: 24825189.
      View in: PubMed
    27. Matsumoto H, Haga K, Ohno I, Hiraoka K, Kimura T, Hermann K, Kasahara N, Anton P, McGowan I. Mucosal gene therapy using a pseudotyped lentivirus vector encoding murine interleukin-10 (mIL-10) suppresses the development and relapse of experimental murine colitis. BMC Gastroenterol. 2014 Apr 08; 14:68. PMID: 24712338.
      View in: PubMed
    28. Qin Y, Fu M, Takahashi M, Iwanami A, Kuga D, Rao RG, Sudhakar D, Huang T, Kiyohara M, Torres K, Dillard C, Inagaki A, Kasahara N, Goodglick L, Braun J, Mischel PS, Gordon LK, Wadehra M. Epithelial membrane protein-2 (EMP2) activates Src protein and is a novel therapeutic target for glioblastoma. J Biol Chem. 2014 May 16; 289(20):13974-85. PMID: 24644285; PMCID: PMC4022868.
    29. Sunaga N, Kaira K, Tomizawa Y, Shimizu K, Imai H, Takahashi G, Kakegawa S, Ohtaki Y, Nagashima T, Kasahara N, Kawashima O, Hisada T, Saito R, Yamada M. Clinicopathological and prognostic significance of interleukin-8 expression and its relationship to KRAS mutation in lung adenocarcinoma. Br J Cancer. 2014 Apr 15; 110(8):2047-53. PMID: 24577055.
      View in: PubMed
    30. Reebye V, Sætrom P, Mintz PJ, Huang KW, Swiderski P, Peng L, Liu C, Liu X, Lindkaer-Jensen S, Zacharoulis D, Kostomitsopoulos N, Kasahara N, Nicholls JP, Jiao LR, Pai M, Spalding DR, Mizandari M, Chikovani T, Emara MM, Haoudi A, Tomalia DA, Rossi JJ, Habib NA. Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo. Hepatology. 2014 Jan; 59(1):216-27. PMID: 23929703.
      View in: PubMed
    31. Kubo S, Takagi-Kimura M, Logg CR, Kasahara N. Highly efficient tumor transduction and antitumor efficacy in experimental human malignant mesothelioma using replicating gibbon ape leukemia virus. Cancer Gene Ther. 2013 Dec; 20(12):671-7. PMID: 24201868.
      View in: PubMed
    32. Pham LK, Liang M, Adisetiyo HA, Liao CP, Cohen MB, Tahara SM, Frenkel B, Kasahara N, Roy-Burman P. Contextual effect of repression of bone morphogenetic protein activity in prostate cancer. Endocr Relat Cancer. 2013 Dec; 20(6):861-74. PMID: 24042462.
      View in: PubMed
    33. Takagi-Kimura M, Yamano T, Tamamoto A, Okamura N, Okamura H, Hashimoto-Tamaoki T, Tagawa M, Kasahara N, Kubo S. Enhanced antitumor efficacy of fiber-modified, midkine promoter-regulated oncolytic adenovirus in human malignant mesothelioma. Cancer Sci. 2013 Nov; 104(11):1433-9. PMID: 23962292.
      View in: PubMed
    34. Hickey MJ, Kasahara N, Mueller BM, Kruse CA. Combining cellular and gene therapy approaches for treatment of intracranial tumors. Oncoimmunology. 2013 Oct 01; 2(10):e25989. PMID: 24244896.
      View in: PubMed
    35. Mintz PJ, Huang KW, Reebye V, Nteliopoulos G, Lai HS, Sætrom P, Kasahara N, Jensen S, Pai M, Gordon MY, Marley SB, Behan R, Spalding DR, Haoudi A, Emara MM, Nicholls J, Rossi JJ, Habib NA. Exploiting human CD34+ stem cell-conditioned medium for tissue repair. Mol Ther. 2014 Jan; 22(1):149-59. PMID: 23985698.
      View in: PubMed
    36. Huang TT, Hlavaty J, Ostertag D, Espinoza FL, Martin B, Petznek H, Rodriguez-Aguirre M, Ibañez CE, Kasahara N, Gunzburg W, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM. Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model. Cancer Gene Ther. 2013 Oct; 20(10):544-51. PMID: 23969884.
      View in: PubMed
    37. Kasahara N, Kikuchi T, Doi J, Teratani T, Fujimoto Y, Uemoto S, Yasuda Y, Kobayashi E. Luminescence-based assay to screen preservation solutions for optimal ability to maintain viability of rat intestinal grafts. Transplant Proc. 2013 Jul-Aug; 45(6):2486-90. PMID: 23953567.
      View in: PubMed
    38. Hickey MJ, Malone CC, Erickson KL, Lin A, Soto H, Ha ET, Kamijima S, Inagaki A, Takahashi M, Kato Y, Kasahara N, Mueller BM, Kruse CA. Combined alloreactive CTL cellular therapy with prodrug activator gene therapy in a model of breast cancer metastatic to the brain. Clin Cancer Res. 2013 Aug 01; 19(15):4137-48. PMID: 23780889; PMCID: PMC3939036.
    39. Reebye V, Sætrom P, Mintz PJ, Rossi JJ, Kasahara N, Nteliopoulos G, Nicholls J, Haoudi A, Gordon M, Habib NA. A Short-activating RNA Oligonucleotide Targeting the Islet ß-cell Transcriptional Factor MafA in CD34(+) Cells. Mol Ther Nucleic Acids. 2013 Jun 04; 2:e97. PMID: 23736775.
      View in: PubMed
    40. Hacke K, Treger JA, Bogan BT, Schiestl RH, Kasahara N. Genetic modification of mouse bone marrow by lentiviral vector-mediated delivery of hypoxanthine-Guanine phosphoribosyltransferase short hairpin RNA confers chemoprotection against 6-thioguanine cytotoxicity. Transplant Proc. 2013 Jun; 45(5):2040-4. PMID: 23769104.
      View in: PubMed
    41. Yin D, Zhai Y, Gruber HE, Ibanez CE, Robbins JM, Kells AP, Kasahara N, Forsayeth J, Jolly DJ, Bankiewicz KS. Convection-enhanced delivery improves distribution and efficacy of tumor-selective retroviral replicating vectors in a rodent brain tumor model. Cancer Gene Ther. 2013 Jun; 20(6):336-41. PMID: 23703472; PMCID: PMC3733370.
    42. Lam P, Khan G, Stripecke R, Hui KM, Kasahara N, Peng KW, Guinn BA. The innovative evolution of cancer gene and cellular therapies. Cancer Gene Ther. 2013 Mar; 20(3):141-9. PMID: 23370333.
      View in: PubMed
    43. Cicciarelli JC, Kasahara N, Lemp NA, Adamson R, Dembitsky W, Browne B, Steinberg S. Immunoglobulin G subclass analysis of HLA donor specific antibodies in heart and renal transplant recipients. Clin Transpl. 2013; 413-22. PMID: 25095537.
      View in: PubMed
    44. Lemp NA, Haga K, Hacke K, Treger JA, Bogan BT, Faure-Kumar E, Logg CR, Kruse CA, Cicciarelli JC, Kasahara N. Reduction of HLA class I expression by ribonucleic acid interference mitigates allogenicity of human primary and Immortalized cells. Clin Transpl. 2013; 93-101. PMID: 25095496.
      View in: PubMed
    45. Janson C, Kasahara N, Prendergast GC, Colicelli J. RIN3 is a negative regulator of mast cell responses to SCF. PLoS One. 2012; 7(11):e49615. PMID: 23185384; PMCID: PMC3502454.
    46. Yamahira A, Narita M, Ishii K, Jayathilake RM, Iwabuchi M, Satoh N, Uchiyama T, Taniguchi T, Hashimoto S, Kasahara N, Faure E, Bogan B, Takizawa J, Sone H, Takahashi M. Enhancement of antigen presenting ability in the leukemic plasmacytoid dendritic cell line (PMDC05) by lentiviral vector-mediated transduction of CD80 gene. Leuk Res. 2012 Dec; 36(12):1541-6. PMID: 23040531.
      View in: PubMed
    47. Voutila J, Sætrom P, Mintz P, Sun G, Alluin J, Rossi JJ, Habib NA, Kasahara N. Gene Expression Profile Changes After Short-activating RNA-mediated Induction of Endogenous Pluripotency Factors in Human Mesenchymal Stem Cells. Mol Ther Nucleic Acids. 2012 Aug 07; 1:e35. PMID: 23344177.
      View in: PubMed
    48. Mintz PJ, Sætrom P, Reebye V, Lundbæk MB, Lao K, Rossi JJ, Gaensler KM, Kasahara N, Nicholls JP, Jensen S, Haoudi A, Emara MM, Gordon MY, Habib NA. MicroRNA-181a* Targets Nanog in a Subpopulation of CD34(+) Cells Isolated From Peripheral Blood. Mol Ther Nucleic Acids. 2012 Aug 07; 1:e34. PMID: 23344176.
      View in: PubMed
    49. Lemp NA, Hiraoka K, Kasahara N, Logg CR. Cryptic transcripts from a ubiquitous plasmid origin of replication confound tests for cis-regulatory function. Nucleic Acids Res. 2012 Aug; 40(15):7280-90. PMID: 22618870.
      View in: PubMed
    50. Perez OD, Logg CR, Hiraoka K, Diago O, Burnett R, Inagaki A, Jolson D, Amundson K, Buckley T, Lohse D, Lin A, Burrascano C, Ibanez C, Kasahara N, Gruber HE, Jolly DJ. Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression. Mol Ther. 2012 Sep; 20(9):1689-98. PMID: 22547150.
      View in: PubMed
    51. Collins SA, Hiraoka K, Inagaki A, Kasahara N, Tangney M. PET imaging for gene & cell therapy. Curr Gene Ther. 2012 Feb 01; 12(1):20-32. PMID: 22263921.
      View in: PubMed
    52. Cronin M, Akin AR, Collins SA, Meganck J, Kim JB, Baban CK, Joyce SA, van Dam GM, Zhang N, van Sinderen D, O'Sullivan GC, Kasahara N, Gahan CG, Francis KP, Tangney M. High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting. PLoS One. 2012; 7(1):e30940. PMID: 22295120.
      View in: PubMed
    53. Logg CR, Robbins JM, Jolly DJ, Gruber HE, Kasahara N. Retroviral replicating vectors in cancer. Methods Enzymol. 2012; 507:199-228. PMID: 22365776.
      View in: PubMed
    54. Ostertag D, Amundson KK, Lopez Espinoza F, Martin B, Buckley T, Galvão da Silva AP, Lin AH, Valenta DT, Perez OD, Ibañez CE, Chen CI, Pettersson PL, Burnett R, Daublebsky V, Hlavaty J, Gunzburg W, Kasahara N, Gruber HE, Jolly DJ, Robbins JM. Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector. Neuro Oncol. 2012 Feb; 14(2):145-59. PMID: 22070930.
      View in: PubMed
    55. Nitsche C, Edderkaoui M, Moore RM, Eibl G, Kasahara N, Treger J, Grippo PJ, Mayerle J, Lerch MM, Gukovskaya AS. The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation. Gastroenterology. 2012 Feb; 142(2):377-87.e1-5. PMID: 22044669.
      View in: PubMed
    56. Hacke K, Szakmary A, Cuddihy AR, Rozengurt N, Lemp NA, Aubrecht J, Lawson GW, Rao NP, Crooks GM, Schiestl RH, Kasahara N. Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow. Exp Hematol. 2012 Jan; 40(1):3-13.e3. PMID: 22001673; PMCID: PMC4305396.
    57. Kawasaki Y, Tamamoto A, Takagi-Kimura M, Maeyama Y, Yamaoka N, Terada N, Okamura H, Kasahara N, Kubo S. Replication-competent retrovirus vector-mediated prodrug activator gene therapy in experimental models of human malignant mesothelioma. Cancer Gene Ther. 2011 Aug; 18(8):571-8. PMID: 21660062.
      View in: PubMed
    58. Pincha M, Salguero G, Wedekind D, Sundarasetty BS, Lin A, Kasahara N, Brugman MH, Jirmo AC, Modlich U, Gutzmer R, Büsche G, Ganser A, Stripecke R. Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells. Gene Ther. 2011 Aug; 18(8):750-64. PMID: 21412283; PMCID: PMC3155152.
    59. Kubo S, Haga K, Tamamoto A, Palmer DJ, Ng P, Okamura H, Kasahara N. Adenovirus-retrovirus hybrid vectors achieve highly enhanced tumor transduction and antitumor efficacy in vivo. Mol Ther. 2011 Jan; 19(1):76-82. PMID: 20808291.
      View in: PubMed
    60. Kubo S, Kawasaki Y, Yamaoka N, Tagawa M, Kasahara N, Terada N, Okamura H. Complete regression of human malignant mesothelioma xenografts following local injection of midkine promoter-driven oncolytic adenovirus. J Gene Med. 2010 Aug; 12(8):681-92. PMID: 20635326.
      View in: PubMed
    61. Kimura T, Hiraoka K, Kasahara N, Logg CR. Optimization of enzyme-substrate pairing for bioluminescence imaging of gene transfer using Renilla and Gaussia luciferases. J Gene Med. 2010 Jun; 12(6):528-37. PMID: 20527045.
      View in: PubMed
    62. Tai CK, Wang W, Lai YH, Logg CR, Parker WB, Li YF, Hong JS, Sorscher EJ, Chen TC, Kasahara N. Enhanced efficiency of prodrug activation therapy by tumor-selective replicating retrovirus vectors armed with the Escherichia coli purine nucleoside phosphorylase gene. Cancer Gene Ther. 2010 Sep; 17(9):614-23. PMID: 20467451.
      View in: PubMed
    63. Matsumoto H, Kimura T, Haga K, Kasahara N, Anton P, McGowan I. Effective in vivo and ex vivo gene transfer to intestinal mucosa by VSV-G-pseudotyped lentiviral vectors. BMC Gastroenterol. 2010 May 11; 10:44. PMID: 20459837.
      View in: PubMed
    64. Guinn B, Casey G, Möller MG, Kasahara N, O'Sullivan GC, Peng KW, Tangney M. International Society for Cell and Gene Therapy of Cancer 2009 Annual Meeting held in Cork, Ireland. Hum Gene Ther. 2010 Jan; 21(1):9-26. PMID: 20017714.
      View in: PubMed
    65. Kubo S, Kataoka M, Tateno C, Yoshizato K, Kawasaki Y, Kimura T, Faure-Kumar E, Palmer DJ, Ng P, Okamura H, Kasahara N. In vivo stable transduction of humanized liver tissue in chimeric mice via high-capacity adenovirus-lentivirus hybrid vector. Hum Gene Ther. 2010 Jan; 21(1):40-50. PMID: 19725756.
      View in: PubMed
    66. Hacke K, Falahati R, Flebbe-Rehwaldt L, Kasahara N, Gaensler KM. Suppression of HLA expression by lentivirus-mediated gene transfer of siRNA cassettes and in vivo chemoselection to enhance hematopoietic stem cell transplantation. Immunol Res. 2009; 44(1-3):112-26. PMID: 19048410; PMCID: PMC2938774.
    67. Cicciarelli J, Cho YW, Koss M, Helstab-Houston K, Mendez R, Kasahara N, Hutchinson IV, Shah T. ASSOCIATION BETWEEN DE NOVO DONOR SPECIFIC HLA ANTIBODY, C4D STAINING IN RENAL GRAFT BIOPSY AND GRAFT OUTCOME: A SINGLE CENTER EXPERIENCE. J Nephrol Ren Transplant. 2009; 2(2):69-74. PMID: 22514590.
      View in: PubMed
    68. Haga K, Tomioka A, Liao CP, Kimura T, Matsumoto H, Ohno I, Hermann K, Logg CR, Jiao J, Tanaka M, Hirao Y, Wu H, Kruse CA, Roy-Burman P, Kasahara N. PTEN knockout prostate cancer as a model for experimental immunotherapy. J Urol. 2009 Jan; 181(1):354-62. PMID: 19010487; PMCID: PMC2838731.
    69. Baranick BT, Lemp NA, Nagashima J, Hiraoka K, Kasahara N, Logg CR. Splicing mediates the activity of four putative cellular internal ribosome entry sites. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4733-8. PMID: 18326627.
      View in: PubMed
    70. Tai CK, Kasahara N. Replication-competent retrovirus vectors for cancer gene therapy. Front Biosci. 2008 Jan 01; 13:3083-95. PMID: 17981778.
      View in: PubMed
    71. Cheng JC, Kinjo K, Judelson DR, Chang J, Wu WS, Schmid I, Shankar DB, Kasahara N, Stripecke R, Bhatia R, Landaw EM, Sakamoto KM. CREB is a critical regulator of normal hematopoiesis and leukemogenesis. Blood. 2008 Feb 01; 111(3):1182-92. PMID: 17975014.
      View in: PubMed
    72. Kikuchi E, Menendez S, Ozu C, Ohori M, Cordon-Cardo C, Logg CR, Kasahara N, Bochner BH. Highly efficient gene delivery for bladder cancers by intravesically administered replication-competent retroviral vectors. Clin Cancer Res. 2007 Aug 01; 13(15 Pt 1):4511-8. PMID: 17671137.
      View in: PubMed
    73. Hiraoka K, Kimura T, Logg CR, Tai CK, Haga K, Lawson GW, Kasahara N. Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model. Cancer Res. 2007 Jun 01; 67(11):5345-53. PMID: 17545615.
      View in: PubMed
    74. Kimura T, Koya RC, Anselmi L, Sternini C, Wang HJ, Comin-Anduix B, Prins RM, Faure-Kumar E, Rozengurt N, Cui Y, Kasahara N, Stripecke R. Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression. Mol Ther. 2007 Jul; 15(7):1390-9. PMID: 17505480.
      View in: PubMed
    75. Logg CR, Baranick BT, Lemp NA, Kasahara N. Adaptive evolution of a tagged chimeric gammaretrovirus: identification of novel cis-acting elements that modulate splicing. J Mol Biol. 2007 Jun 22; 369(5):1214-29. PMID: 17498744.
      View in: PubMed
    76. Guinn BA, Kasahara N, Farzaneh F, Habib NA, Norris JS, Deisseroth AB. Recent advances and current challenges in tumor immunology and immunotherapy. Mol Ther. 2007 Jun; 15(6):1065-71. PMID: 17375068.
      View in: PubMed
    77. Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R. Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines. Mol Ther. 2007 May; 15(5):971-80. PMID: 17375074.
      View in: PubMed
    78. Dalba C, Bellier B, Kasahara N, Klatzmann D. Replication-competent vectors and empty virus-like particles: new retroviral vector designs for cancer gene therapy or vaccines. Mol Ther. 2007 Mar; 15(3):457-66. PMID: 17245356.
      View in: PubMed
    79. Kikuchi E, Menendez S, Ozu C, Ohori M, Cordon-Cardo C, Logg CR, Kasahara N, Bochner BH. Delivery of replication-competent retrovirus expressing Escherichia coli purine nucleoside phosphorylase increases the metabolism of the prodrug, fludarabine phosphate and suppresses the growth of bladder tumor xenografts. Cancer Gene Ther. 2007 Mar; 14(3):279-86. PMID: 17218950.
      View in: PubMed
    80. Sakoda T, Kasahara N, Kedes L, Ohyanagi M. Lentiviral vector-mediated gene transfer to endotherial cells compared with adenoviral and retroviral vectors. Prep Biochem Biotechnol. 2007; 37(1):1-11. PMID: 17134978.
      View in: PubMed
    81. Sakoda T, Kasahara N, Kedes L, Ohyanagi M. Calcium phosphate coprecipitation greatly enhances transduction of cardiac myocytes and vascular smooth muscle cells by lentivirus vectors. Exp Clin Cardiol. 2007; 12(3):133-8. PMID: 18650994.
      View in: PubMed
    82. Buscarini M, Quek ML, Gilliam-Hegarich S, Kasahara N, Bochner B. Adenoviral receptor expression of normal bladder and transitional cell carcinoma of the bladder. Urol Int. 2007; 78(2):160-6. PMID: 17293658.
      View in: PubMed
    83. Haga K, Lemp NA, Logg CR, Nagashima J, Faure-Kumar E, Gomez GG, Kruse CA, Mendez R, Stripecke R, Kasahara N, Kasahara NA, Cicciarelli JC. Permanent, lowered HLA class I expression using lentivirus vectors with shRNA constructs: Averting cytotoxicity by alloreactive T lymphocytes. Transplant Proc. 2006 Dec; 38(10):3184-8. PMID: 17175217; PMCID: PMC1868890.
    84. Hiraoka K, Kimura T, Logg CR, Kasahara N. Tumor-selective gene expression in a hepatic metastasis model after locoregional delivery of a replication-competent retrovirus vector. Clin Cancer Res. 2006 Dec 01; 12(23):7108-16. PMID: 17145835.
      View in: PubMed
    85. Guinn BA, Norris JS, Huang L, Farzaneh F, Kasahara N, Deisseroth AB. International Society for Cell and Gene Therapy of Cancer (ISCGT) annual meeting: conference overview and introduction to the symposium papers. Cancer Immunol Immunother. 2006 Nov; 55(11):1406-11. PMID: 16783577.
      View in: PubMed
    86. Farzaneh L, Kasahara N, Farzaneh F. The strange case of TGN1412. Cancer Immunol Immunother. 2007 Feb; 56(2):129-34. PMID: 16783575.
      View in: PubMed
    87. Oshikiri T, Miyamoto M, Hiraoka K, Shichinohe T, Kawarada Y, Kato K, Suzuoki M, Nakakubo Y, Kondo S, Dosaka-Akita H, Kasahara N, Katoh H. Transcriptional targeting of adenovirus vectors with the squamous cell carcinoma-specific antigen-2 promoter for selective apoptosis induction in lung cancer. Cancer Gene Ther. 2006 Sep; 13(9):856-63. PMID: 16710347.
      View in: PubMed
    88. Kubo S, Seleme MC, Soifer HS, Perez JL, Moran JV, Kazazian HH, Kasahara N. L1 retrotransposition in nondividing and primary human somatic cells. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8036-41. PMID: 16698926.
      View in: PubMed
    89. Wang W, Tai CK, Kershaw AD, Solly SK, Klatzmann D, Kasahara N, Chen TC. Use of replication-competent retroviral vectors in an immunocompetent intracranial glioma model. Neurosurg Focus. 2006 Apr 15; 20(4):E25. PMID: 16709031.
      View in: PubMed
    90. Wang W, Zhu NL, Chua J, Swenson S, Costa FK, Schmitmeier S, Sosnowski BA, Shichinohe T, Kasahara N, Chen TC. Retargeting of adenoviral vector using basic fibroblast growth factor ligand for malignant glioma gene therapy. J Neurosurg. 2005 Dec; 103(6):1058-66. PMID: 16381193.
      View in: PubMed
    91. Dalba C, Klatzmann D, Logg CR, Kasahara N. Beyond oncolytic virotherapy: replication-competent retrovirus vectors for selective and stable transduction of tumors. Curr Gene Ther. 2005 Dec; 5(6):655-67. PMID: 16457654.
      View in: PubMed
    92. Tai CK, Wang WJ, Chen TC, Kasahara N. Single-shot, multicycle suicide gene therapy by replication-competent retrovirus vectors achieves long-term survival benefit in experimental glioma. Mol Ther. 2005 Nov; 12(5):842-51. PMID: 16257382.
      View in: PubMed
    93. Soifer HS, Kasahara N. Retrotransposon-adenovirus hybrid vectors: efficient delivery and stable integration of transgenes via a two-stage mechanism. Curr Gene Ther. 2004 Dec; 4(4):373-84. PMID: 15578988.
      View in: PubMed
    94. Nakamura S, Nakamura R, Shibata K, Kobayashi M, Sahara N, Shigeno K, Shinjo K, Naito K, Ohnishi K, Kasahara N, Iwaki Y. Development of packaging cell lines for generation of adeno-associated virus vectors by lentiviral gene transfer of trans-complementary components. Eur J Haematol. 2004 Oct; 73(4):285-94. PMID: 15347316.
      View in: PubMed
    95. Koya RC, Weber JS, Kasahara N, Lau R, Villacres MC, Levine AM, Stripecke R. Making dendritic cells from the inside out: lentiviral vector-mediated gene delivery of granulocyte-macrophage colony-stimulating factor and interleukin 4 into CD14+ monocytes generates dendritic cells in vitro. Hum Gene Ther. 2004 Aug; 15(8):733-48. PMID: 15319031.
      View in: PubMed
    96. Woodley DT, Keene DR, Atha T, Huang Y, Ram R, Kasahara N, Chen M. Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo. Mol Ther. 2004 Aug; 10(2):318-26. PMID: 15294178.
      View in: PubMed
    97. Wang Y, Xie J, Yarber FA, Mazurek C, Trousdale MD, Medina-Kauwe LK, Kasahara N, Hamm-Alvarez SF. Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland. Gene Ther. 2004 Jun; 11(12):970-81. PMID: 15029229.
      View in: PubMed
    98. Qiao R, Zhou B, Harboe-Schmidt E, Kasahara N, Kim KJ, Liebler JM, Crandall ED, Borok Z. Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer. Hum Gene Ther. 2004 May; 15(5):457-68. PMID: 15144576.
      View in: PubMed
    99. Kikuchi E, Menendez S, Ohori M, Cordon-Cardo C, Kasahara N, Bochner BH. Inhibition of orthotopic human bladder tumor growth by lentiviral gene transfer of endostatin. Clin Cancer Res. 2004 Mar 01; 10(5):1835-42. PMID: 15014038.
      View in: PubMed
    100. Li B, Navarro S, Kasahara N, Comai L. Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. J Biol Chem. 2004 Apr 02; 279(14):13659-67. PMID: 14734561.
      View in: PubMed
    101. Logg CR, Kasahara N. Retrovirus-mediated gene transfer to tumors: utilizing the replicative power of viruses to achieve highly efficient tumor transduction in vivo. Methods Mol Biol. 2004; 246:499-525. PMID: 14970613.
      View in: PubMed
    102. Koya RC, Kasahara N, Favaro PM, Lau R, Ta HQ, Weber JS, Stripecke R. Potent maturation of monocyte-derived dendritic cells after CD40L lentiviral gene delivery. J Immunother. 2003 Sep-Oct; 26(5):451-60. PMID: 12973034.
      View in: PubMed
    103. Stripecke R, Koya RC, Ta HQ, Kasahara N, Levine AM. The use of lentiviral vectors in gene therapy of leukemia: combinatorial gene delivery of immunomodulators into leukemia cells by state-of-the-art vectors. Blood Cells Mol Dis. 2003 Jul-Aug; 31(1):28-37. PMID: 12850480.
      View in: PubMed
    104. Tai CK, Logg CR, Park JM, Anderson WF, Press MF, Kasahara N. Antibody-mediated targeting of replication-competent retroviral vectors. Hum Gene Ther. 2003 May 20; 14(8):789-802. PMID: 12804141.
      View in: PubMed
    105. Wang Y, Jerdeva G, Yarber FA, da Costa SR, Xie J, Qian L, Rose CM, Mazurek C, Kasahara N, Mircheff AK, Hamm-Alvarez SF. Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells. J Cell Sci. 2003 May 15; 116(Pt 10):2051-65. PMID: 12679381.
      View in: PubMed
    106. Chen M, Li W, Fan J, Kasahara N, Woodley D. An efficient gene transduction system for studying gene function in primary human dermal fibroblasts and epidermal keratinocytes. Clin Exp Dermatol. 2003 Mar; 28(2):193-9. PMID: 12653712.
      View in: PubMed
    107. Wang WJ, Tai CK, Kasahara N, Chen TC. Highly efficient and tumor-restricted gene transfer to malignant gliomas by replication-competent retroviral vectors. Hum Gene Ther. 2003 Jan 20; 14(2):117-27. PMID: 12614563.
      View in: PubMed
    108. Sakoda T, Kasahara N, Kedes L. Lentivirus vector-mediated gene transfer to cardiomyocytes. Methods Mol Biol. 2003; 219:53-70. PMID: 12596998.
      View in: PubMed
    109. Logg CR, Logg A, Matusik RJ, Bochner BH, Kasahara N. Tissue-specific transcriptional targeting of a replication-competent retroviral vector. J Virol. 2002 Dec; 76(24):12783-91. PMID: 12438603.
      View in: PubMed
    110. Chen M, Kasahara N, Keene DR, Chan L, Hoeffler WK, Finlay D, Barcova M, Cannon PM, Mazurek C, Woodley DT. Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Nat Genet. 2002 Dec; 32(4):670-5. PMID: 12426566.
      View in: PubMed
    111. Koya RC, Kasahara N, Pullarkat V, Levine AM, Stripecke R. Transduction of acute myeloid leukemia cells with third generation self-inactivating lentiviral vectors expressing CD80 and GM-CSF: effects on proliferation, differentiation, and stimulation of allogeneic and autologous anti-leukemia immune responses. Leukemia. 2002 Sep; 16(9):1645-54. PMID: 12200676.
      View in: PubMed
    112. Hiraoka K, Hida Y, Miyamoto M, Oshikiri T, Suzuoki M, Nakakubo Y, Shinohara T, Itoh T, Shichinohe T, Kondo S, Kasahara N, Katoh H. High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma is an unfavorable prognostic marker. Int J Cancer. 2002 May 20; 99(3):418-23. PMID: 11992411.
      View in: PubMed
    113. Soifer H, Higo C, Logg CR, Jih LJ, Shichinohe T, Harboe-Schmidt E, Mitani K, Kasahara N. A novel, helper-dependent, adenovirus-retrovirus hybrid vector: stable transduction by a two-stage mechanism. Mol Ther. 2002 May; 5(5 Pt 1):599-608. PMID: 11991751.
      View in: PubMed
    114. Li W, Nadelman C, Gratch NS, Li W, Chen M, Kasahara N, Woodley DT. An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen. Exp Cell Res. 2002 Feb 15; 273(2):219-28. PMID: 11822877.
      View in: PubMed
    115. Borok Z, Harboe-Schmidt JE, Brody SL, You Y, Zhou B, Li X, Cannon PM, Kim KJ, Crandall ED, Kasahara N. Vesicular stomatitis virus G-pseudotyped lentivirus vectors mediate efficient apical transduction of polarized quiescent primary alveolar epithelial cells. J Virol. 2001 Dec; 75(23):11747-54. PMID: 11689655; PMCID: PMC114760.
    116. Medina-Kauwe LK, Maguire M, Kasahara N, Kedes L. Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins. Gene Ther. 2001 Dec; 8(23):1753-61. PMID: 11803394.
      View in: PubMed
    117. Shichinohe T, Bochner BH, Mizutani K, Nishida M, Hegerich-Gilliam S, Naldini L, Kasahara N. Development of lentiviral vectors for antiangiogenic gene delivery. Cancer Gene Ther. 2001 Nov; 8(11):879-89. PMID: 11773978.
      View in: PubMed
    118. Weber E, Anderson WF, Kasahara N. Recent advances in retrovirus vector-mediated gene therapy: teaching an old vector new tricks. Curr Opin Mol Ther. 2001 Oct; 3(5):439-53. PMID: 11699888.
      View in: PubMed
    119. Chang Z, Pan J, Logg C, Kasahara N, Roy-Burman P. A replication-competent feline leukemia virus, subgroup A (FeLV-A), tagged with green fluorescent protein reporter exhibits in vitro biological properties similar to those of the parental FeLV-A. J Virol. 2001 Sep; 75(18):8837-41. PMID: 11507228.
      View in: PubMed
    120. Yoon TK, Shichinohe T, Laquerre S, Kasahara N. Selectively replicating adenoviruses for oncolytic therapy. Curr Cancer Drug Targets. 2001 Aug; 1(2):85-107. PMID: 12188883.
      View in: PubMed
    121. Logg CR, Logg A, Tai CK, Cannon PM, Kasahara N. Genomic stability of murine leukemia viruses containing insertions at the Env-3' untranslated region boundary. J Virol. 2001 Aug; 75(15):6989-98. PMID: 11435579.
      View in: PubMed
    122. Soifer H, Higo C, Kazazian HH, Moran JV, Mitani K, Kasahara N. Stable integration of transgenes delivered by a retrotransposon-adenovirus hybrid vector. Hum Gene Ther. 2001 Jul 20; 12(11):1417-28. PMID: 11485633.
      View in: PubMed
    123. Logg CR, Tai CK, Logg A, Anderson WF, Kasahara N. A uniquely stable replication-competent retrovirus vector achieves efficient gene delivery in vitro and in solid tumors. Hum Gene Ther. 2001 May 20; 12(8):921-32. PMID: 11387057.
      View in: PubMed
    124. Medina-Kauwe LK, Kasahara N, Kedes L. 3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins. Gene Ther. 2001 May; 8(10):795-803. PMID: 11420644.
      View in: PubMed
    125. Lin AH, Kasahara N, Wu W, Stripecke R, Empig CL, Anderson WF, Cannon PM. Receptor-specific targeting mediated by the coexpression of a targeted murine leukemia virus envelope protein and a binding-defective influenza hemagglutinin protein. Hum Gene Ther. 2001 Mar 01; 12(4):323-32. PMID: 11242525.
      View in: PubMed
    126. Song Z, Powell WC, Kasahara N, van Bokhoven A, Miller GJ, Roy-Burman P. The effect of fibroblast growth factor 8, isoform b, on the biology of prostate carcinoma cells and their interaction with stromal cells. Cancer Res. 2000 Dec 01; 60(23):6730-6. PMID: 11118059.
      View in: PubMed
    127. Chen M, O'Toole EA, Muellenhoff M, Medina E, Kasahara N, Woodley DT. Development and characterization of a recombinant truncated type VII collagen "minigene". Implication for gene therapy of dystrophic epidermolysis bullosa. J Biol Chem. 2000 Aug 11; 275(32):24429-35. PMID: 10821839.
      View in: PubMed
    128. Smith E, Redman RA, Logg CR, Coetzee GA, Kasahara N, Frenkel B. Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes. J Biol Chem. 2000 Jun 30; 275(26):19992-20001. PMID: 10867026.
      View in: PubMed
    129. Mohan R, Sivak J, Ashton P, Russo LA, Pham BQ, Kasahara N, Raizman MB, Fini ME. Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. J Biol Chem. 2000 Apr 07; 275(14):10405-12. PMID: 10744729.
      View in: PubMed
    130. Sakoda T, Kasahara N, Hamamori Y, Kedes L. A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes. J Mol Cell Cardiol. 1999 Nov; 31(11):2037-47. PMID: 10591030.
      View in: PubMed
    131. Irie R, Hiraoka S, Kasahara N, Nagai K. DNA sequence comparison considering both amino acid and nucleotide insertions/deletions because of evolution and experimental error. J Biotechnol. 1999 Mar 26; 69(1):19-26. PMID: 10201112.
      View in: PubMed
    132. Han X, Kasahara N, Kan YW. Ligand-directed retroviral targeting of human breast cancer cells. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9747-51. PMID: 7568210.
      View in: PubMed
    133. Takahashi T, Shirasawa T, Miyake K, Yahagi Y, Maruyama N, Kasahara N, Kawamura T, Matsumura O, Mitarai T, Sakai O. Protein tyrosine kinases expressed in glomeruli and cultured glomerular cells: Flt-1 and VEGF expression in renal mesangial cells. Biochem Biophys Res Commun. 1995 Apr 06; 209(1):218-26. PMID: 7726838.
      View in: PubMed
    134. Kasahara N, Dozy AM, Kan YW. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. Science. 1994 Nov 25; 266(5189):1373-6. PMID: 7973726.
      View in: PubMed
    135. Sakamoto S, Mizuno M, Kudo H, Suzuki S, Kasahara N, Sugiura Y, Mori T, Nagasawa H. Suppression of mammary tumors by oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil in SHN virgin mice. Anticancer Drugs. 1993 Dec; 4(6):651-5. PMID: 8298164.
      View in: PubMed
    136. Kasahara N. Deletional analysis of the human renin promoter: transcriptional activation by the SV40 enhancer enables identification of promoter regulatory elements in non-renin-expressing cells. Bull Tokyo Med Dent Univ. 1993 Jun; 40(2):79-91. PMID: 8390924.
      View in: PubMed
    137. Sakamoto S, Tajima M, Sawaki K, Suzuki S, Kudo H, Sassa S, Kuwa K, Sugiura Y, Kasahara N, Nagasawa H. Effects of luteinizing hormone-releasing hormone analogue on DNA synthesis in rat prostate and uterus. In Vivo. 1993 Jan-Feb; 7(1):13-6. PMID: 8504203.
      View in: PubMed
    138. Sakamoto S, Mizuno M, Sawaki K, Kudo H, Kasahara N, Suzuki S, Mori T, Nagasawa H. Suppression by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of preneoplastic mammary hyperplastic alveolar nodule formation in SHN virgin mice. Anticancer Res. 1992 Jul-Aug; 12(4):1291-4. PMID: 1503423.
      View in: PubMed
    139. Sakamoto S, Hirai H, Taga H, Uchikoshi T, Sunaga T, Endo Y, Kudo H, Kato T, Kasahara N, Kuwa K. Inhibition by 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene in rats. Anticancer Res. 1991 Mar-Apr; 11(2):561-6. PMID: 1712176.
      View in: PubMed
    140. Sakamoto S, Kuwa K, Kawachi Y, Kudo H, Kasahara N, Kato T, Okamoto R, Taga H, Hirai H, Sunaga T. [Thymidine kinase activities in sera and liver tissues during hepatocarcinogenesis in rats treated with 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB)]. Nihon Gan Chiryo Gakkai Shi. 1990 Dec 20; 25(12):2794-801. PMID: 2074389.
      View in: PubMed
    141. Sakamoto S, Hirai H, Taga H, Uchikoshi T, Sunaga T, Endo Y, Kuwa K, Kudo H, Kawachi Y, Kasahara N. Thymidine kinase and alpha-fetoprotein as biochemical markers of hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene treatment in rats. Carcinogenesis. 1990 Jan; 11(1):145-50. PMID: 1688518.
      View in: PubMed