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Annette Molinaro, PhD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentNeurological Surgery
Address1450 Third St
San Francisco CA 94158
Phone415-476-1640
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    Collapse Biography 
    Collapse Awards and Honors
    UCSF2013Diane D. Ralston Clinical and Basic Neuroscience Teaching Award
    Yale University School of Public Health2008Teacher of the Year Award
    International Statistical Institute2006Elected as a Member
    University of California, Berkeley2004Chin Long Chiang Biostatistics Student of the Year
    University of California, Berkeley2004Evelyn Fix Prize

    Collapse Overview 
    Collapse Overview
    Dr. Molinaro is a principal investigator in the Brain Tumor Research Center at UCSF and the Co-Director of the Clinical and Biostatistics Core for the newly funded UCSF Brain SPORE as well as the Co-Director of the Biospecimen and Biostatistics Core for the newly funded UCSF Brain P01. Dr. Molinaro’s research interests are primarily focused on statistical genetics and computational biology, including prediction, survival analysis and classification with additional curiosities in cancer epidemiology and in the estimation of absolute risk in stratified case-cohort studies. Her research has pertained to predicting clinical outcomes with high-dimensional explanatory variables, such as SNP and methylation arrays, and large-scale epidemiology studies. This has included an adaptation to Classification and Regression Trees (CART) for survival outcomes, the introduction of partDSA, a novel data-adaptive algorithm that builds Boolean combinations of explanatory variables, and a non-parametric method for point estimation based on a stratified case-cohort study design. Dr. Molinaro was recently awarded an R01 by the NCI to expand partDSA for building risk models accommodating various study designs and competing risks. In addition, she has worked with collaborators at the National Cancer Institute (NCI) on comparing cross-validation approaches to validating predictors in small sample sizes and the power of data mining methods for detecting genetic associations and interactions.


    Collapse Research 
    Collapse Research Activities and Funding
    Novel Tree-based Statistical Methods for Cancer Risk Prediction
    NIH/NCI R01CA163687Jul 10, 2012 - Apr 30, 2016
    Role: Principal Investigator
    Statistical Methods for Predicting Survival Outcomes from Genomic Data
    NIH/NCI K22CA123146Jul 6, 2006 - Jun 30, 2009
    Role: Principal Investigator
    Yale SPORE in Skin Cancer
    NIH P50CA121974Jun 1, 2006 - Aug 31, 2017
    Role: Co-Investigator
    SPORE: Brain Tumore SPORE Grant
    NIH/NCI P50CA097257Sep 20, 2002 - Aug 31, 2018
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Mazor T, Chesnelong C, Pankov A, Jalbert LE, Hong C, Hayes J, Smirnov IV, Marshall R, Souza CF, Shen Y, Viswanath P, Noushmehr H, Ronen SM, Jones SJM, Marra MA, Cairncross JG, Perry A, Nelson SJ, Chang SM, Bollen AW, Molinaro A, Bengtsson H, Olshen AB, Weiss S, Phillips JJ, Luchman HA, Costello JF. Clonal expansion and epigenetic reprogramming following deletion or amplification of mutant IDH1. Proc Natl Acad Sci U S A. 2017 Sep 15. PMID: 28916733.
      View in: PubMed
    2. Anwar M, Molinaro A, Morin O, Chang SM, Haas-Kogan DA, Nelson SJ, Lupo JM. Identifying Voxels at Risk for Progression in Glioblastoma Based on Dosimetry, Physiologic and Metabolic MRI. Radiat Res. 2017 Sep; 188(3):303-313. PMID: 28723274.
      View in: PubMed
    3. Jalbert LE, Elkhaled A, Phillips JJ, Neill E, Williams A, Crane JC, Olson MP, Molinaro A, Berger MS, Kurhanewicz J, Ronen SM, Chang SM, Nelson SJ. Metabolic Profiling of IDH Mutation and Malignant Progression in Infiltrating Glioma. Sci Rep. 2017 Mar 22; 7:44792. PMID: 28327577.
      View in: PubMed
    4. Pekmezci M, Rice T, Molinaro A, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance DH, Clarke J, Taylor JW, Luks T, Wiencke JK, Jenkins RB, Wrensch MR. Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. Acta Neuropathol. 2017 Jun; 133(6):1001-1016. PMID: 28255664.
      View in: PubMed
    5. Nelson SJ, Kadambi AK, Park I, Li Y, Crane J, Olson M, Molinaro A, Roy R, Butowski N, Cha S, Chang S, et al. Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen. Neuro Oncol. 2017 03 01; 19(3):430-439. PMID: 27576874.
      View in: PubMed
    6. Clarke JL, Molinaro A, Cabrera JR, DeSilva AA, Rabbitt JE, Prey J, Drummond DC, Kim J, Noble C, Fitzgerald JB, Chang SM, Butowski NA, Taylor JW, Park JW, Prados MD. A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma. Cancer Chemother Pharmacol. 2017 Mar; 79(3):603-610. PMID: 28233053.
      View in: PubMed
    7. Wahl M, Phillips JJ, Molinaro A, Lin Y, Perry A, Haas-Kogan DA, Costello JF, Dayal M, Butowski N, Clarke JL, Prados M, Nelson S, Berger MS, Chang SM. Chemotherapy for adult low-grade gliomas: clinical outcomes by molecular subtype in a phase II study of adjuvant temozolomide. Neuro Oncol. 2017 02 01; 19(2):242-251. PMID: 27571885.
      View in: PubMed
    8. Kuang R, Jahangiri A, Mascharak S, Nguyen A, Chandra A, Flanigan PM, Yagnik G, Wagner JR, De Lay M, Carrera D, Castro BA, Hayes J, Sidorov M, Garcia JL, Eriksson P, Ronen S, Phillips J, Molinaro A, Koliwad S, Aghi MK. GLUT3 upregulation promotes metabolic reprogramming associated with antiangiogenic therapy resistance. JCI Insight. 2017 Jan 26; 2(2):e88815. PMID: 28138554.
      View in: PubMed
    9. Neill E, Luks T, Dayal M, Phillips JJ, Perry A, Jalbert LE, Cha S, Molinaro A, Chang SM, Nelson SJ. Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma. J Neurooncol. 2017 Mar; 132(1):171-179. PMID: 28124178.
      View in: PubMed
    10. Imber BS, Kanungo I, Braunstein S, Barani IJ, Fogh SE, Nakamura JL, Berger MS, Chang EF, Molinaro A, Cabrera JR, McDermott MW, Sneed PK, Aghi MK. Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience. Neurosurgery. 2017 Jan 01; 80(1):129-139. PMID: 27428784.
      View in: PubMed
    11. Zhang Y, Cartmel B, Choy CC, Molinaro A, Leffell DJ, Bale AE, Mayne ST, Ferrucci LM. Body mass index, height and early-onset basal cell carcinoma in a case-control study. Cancer Epidemiol. 2017 Feb; 46:66-72. PMID: 28039770.
      View in: PubMed
    12. Zygourakis CC, Imber BS, Chen R, Han SJ, Blevins L, Molinaro A, Kahn JG, Aghi MK. Cost-Effectiveness Analysis of Surgical versus Medical Treatment of Prolactinomas. J Neurol Surg B Skull Base. 2017 Apr; 78(2):125-131. PMID: 28321375.
      View in: PubMed
    13. Han SJ, Reis G, Kohanbash G, Shrivastav S, Magill ST, Molinaro A, McDermott MW, Theodosopoulos PV, Aghi MK, Berger MS, Butowski NA, Barani I, Phillips JJ, Perry A, Okada H. Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma. J Neurooncol. 2016 Dec; 130(3):543-552. PMID: 27624915.
      View in: PubMed
    14. Roddy E, Sear K, Felton E, Tamrazi B, Gauvain K, Torkildson J, Buono BD, Samuel D, Haas-Kogan DA, Chen J, Goldsby RE, Banerjee A, Lupo JM, Molinaro A, Fullerton HJ, Mueller S. Presence of cerebral microbleeds is associated with worse executive function in pediatric brain tumor survivors. Neuro Oncol. 2016 Nov; 18(11):1548-1558. PMID: 27540084.
      View in: PubMed
    15. Molinaro A, Sison JD, Ljung BM, Tlsty TD, Kerlikowske K. Risk prediction for local versus regional/metastatic tumors after initial ductal carcinoma in situ diagnosis treated by lumpectomy. Breast Cancer Res Treat. 2016 Jun; 157(2):351-361. PMID: 27146587.
      View in: PubMed
    16. Steingrimsson JA, Diao L, Molinaro A, Strawderman RL. Doubly robust survival trees. Stat Med. 2016 Sep 10; 35(20):3595-612. PMID: 27037609.
      View in: PubMed
    17. Moore CL, Daniels B, Singh D, Luty S, Gunabushanam G, Ghita M, Molinaro A, Gross CP. Ureteral Stones: Implementation of a Reduced-Dose CT Protocol in Patients in the Emergency Department with Moderate to High Likelihood of Calculi on the Basis of STONE Score. Radiology. 2016 Sep; 280(3):743-51. PMID: 26943230.
      View in: PubMed
    18. Mukherjee J, Ohba S, See WL, Phillips JJ, Molinaro A, Pieper RO. PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells. Int J Cancer. 2016 Jul 01; 139(1):99-111. PMID: 26874904.
      View in: PubMed
    19. Jalbert LE, Neill E, Phillips JJ, Lupo JM, Olson MP, Molinaro A, Berger MS, Chang SM, Nelson SJ. Magnetic resonance analysis of malignant transformation in recurrent glioma. Neuro Oncol. 2016 Aug; 18(8):1169-79. PMID: 26911151; PMCID: PMC4933480.
    20. Chang EF, Breshears JD, Raygor KP, Lau D, Molinaro A, Berger MS. Stereotactic probability and variability of speech arrest and anomia sites during stimulation mapping of the language dominant hemisphere. J Neurosurg. 2017 Jan; 126(1):114-121. PMID: 26894457.
      View in: PubMed
    21. Daniels B, Gross CP, Molinaro A, Singh D, Luty S, Jessey R, Moore CL. STONE PLUS: Evaluation of Emergency Department Patients With Suspected Renal Colic, Using a Clinical Prediction Tool Combined With Point-of-Care Limited Ultrasonography. Ann Emerg Med. 2016 Apr; 67(4):439-48. PMID: 26747219.
      View in: PubMed
    22. Walsh KM, Codd V, Rice T, Nelson CP, Smirnov IV, McCoy LS, Hansen HM, Elhauge E, Ojha J, Francis SS, Madsen NR, Bracci PM, Pico AR, Molinaro A, Tihan T, Berger MS, Chang SM, Prados MD, Jenkins RB, Wiemels JL, Telomere Group EC, Samani NJ, Wiencke JK, Wrensch MR. Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. Oncotarget. 2015 Dec 15; 6(40):42468-77. PMID: 26646793; PMCID: PMC4767445.
    23. Molinaro A, Wrensch MR, Jenkins RB, Eckel-Passow JE. Statistical considerations on prognostic models for glioma. Neuro Oncol. 2016 May; 18(5):609-23. PMID: 26657835; PMCID: PMC4827041 [Available on 05/01/17].
    24. Wen Q, Jalilian L, Lupo JM, Li Y, Roy R, Molinaro A, Chang SM, Prados M, Butowski N, Clarke J, Nelson SJ. Association of Diffusion and Anatomic Imaging Parameters with Survival for Patients with Newly Diagnosed Glioblastoma Participating in Two Different Clinical Trials. Transl Oncol. 2015 Dec; 8(6):446-55. PMID: 26692525; PMCID: PMC4700297.
    25. Lau D, Hervey-Jumper SL, Chang S, Molinaro A, McDermott MW, Phillips JJ, Berger MS. A prospective Phase II clinical trial of 5-aminolevulinic acid to assess the correlation of intraoperative fluorescence intensity and degree of histologic cellularity during resection of high-grade gliomas. J Neurosurg. 2016 May; 124(5):1300-9. PMID: 26544781.
      View in: PubMed
    26. Butowski N, Colman H, De Groot JF, Omuro AM, Nayak L, Wen PY, Cloughesy TF, Marimuthu A, Haidar S, Perry A, Huse J, Phillips J, West BL, Nolop KB, Hsu HH, Ligon KL, Molinaro A, Prados M. Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study. Neuro Oncol. 2016 Apr; 18(4):557-64. PMID: 26449250; PMCID: PMC4799682 [Available on 04/01/17].
    27. Mazor T, Pankov A, Johnson BE, Hong C, Hamilton EG, Bell RJ, Smirnov IV, Reis GF, Phillips JJ, Barnes MJ, Idbaih A, Alentorn A, Kloezeman JJ, Lamfers ML, Bollen AW, Taylor BS, Molinaro A, Olshen AB, Chang SM, Song JS, Costello JF. DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors. Cancer Cell. 2015 Sep 14; 28(3):307-317. PMID: 26373278; PMCID: PMC4573399.
    28. Hervey-Jumper SL, Li J, Osorio JA, Lau D, Molinaro A, Benet A, Berger MS. Surgical assessment of the insula. Part 2: validation of the Berger-Sanai zone classification system for predicting extent of glioma resection. J Neurosurg. 2016 Feb; 124(2):482-8. PMID: 26339856.
      View in: PubMed
    29. Racine CA, Li J, Molinaro A, Butowski N, Berger MS. Neurocognitive Function in Newly Diagnosed Low-grade Glioma Patients Undergoing Surgical Resection With Awake Mapping Techniques. Neurosurgery. 2015 Sep; 77(3):371-9; discussion 379. PMID: 25930064.
      View in: PubMed
    30. Rice T, Lachance DH, Molinaro A, Eckel-Passow JE, Walsh KM, Barnholtz-Sloan J, Ostrom QT, Francis SS, Wiemels J, Jenkins RB, Wiencke JK, Wrensch MR. Understanding inherited genetic risk of adult glioma - a review. Neurooncol Pract. 2016 Mar; 3(1):10-16. PMID: 26941959.
      View in: PubMed
    31. Han SJ, Rutledge WC, Molinaro A, Chang SM, Clarke JL, Prados MD, Taylor JW, Berger MS, Butowski NA. The Effect of Timing of Concurrent Chemoradiation in Patients With Newly Diagnosed Glioblastoma. Neurosurgery. 2015 Aug; 77(2):248-53; discussion 253. PMID: 25856113; PMCID: PMC4506198.
    32. Han SJ, Englot DJ, Birk H, Molinaro A, Chang SM, Clarke JL, Prados MD, Taylor JW, Berger MS, Butowski NA. Impact of Timing of Concurrent Chemoradiation for Newly Diagnosed Glioblastoma: A Critical Review of Current Evidence. Neurosurgery. 2015 Aug; 62 Suppl 1:160-5. PMID: 26181937.
      View in: PubMed
    33. Lupo JM, Molinaro A, Essock-Burns E, Butowski N, Chang SM, Cha S, Nelson SJ. The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with glioma. Neuro Oncol. 2016 Jan; 18(1):87-95. PMID: 26206774.
      View in: PubMed
    34. Seymour ZA, Sneed PK, Gupta N, Lawton MT, Molinaro A, Young W, Dowd CF, Halbach VV, Higashida RT, McDermott MW. Volume-staged radiosurgery for large arteriovenous malformations: an evolving paradigm. J Neurosurg. 2016 Jan; 124(1):163-74. PMID: 26140495.
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    35. Eckel-Passow JE, Lachance DH, Molinaro A, Walsh KM, Decker PA, Sicotte H, Pekmezci M, Rice T, Kosel ML, Smirnov IV, Sarkar G, Caron AA, Kollmeyer TM, Praska CE, Chada AR, Halder C, Hansen HM, McCoy LS, Bracci PM, Marshall R, Zheng S, Reis GF, Pico AR, O'Neill BP, Buckner JC, Giannini C, Huse JT, Perry A, Tihan T, Berger MS, Chang SM, Prados MD, Wiemels J, Wiencke JK, Wrensch MR, Jenkins RB. Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. N Engl J Med. 2015 Jun 25; 372(26):2499-508. PMID: 26061753; PMCID: PMC4489704.
    36. Walsh KM, Wiencke JK, Lachance DH, Wiemels JL, Molinaro A, Eckel-Passow JE, Jenkins RB, Wrensch MR. Telomere maintenance and the etiology of adult glioma. Neuro Oncol. 2015 Nov; 17(11):1445-52. PMID: 26014050; PMCID: PMC4648301 [Available on 11/01/16].
    37. Sneed PK, Mendez J, Vemer-van den Hoek JG, Seymour ZA, Ma L, Molinaro A, Fogh SE, Nakamura JL, McDermott MW. Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors. J Neurosurg. 2015 Aug; 123(2):373-86. PMID: 25978710.
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    38. Breshears JD, Molinaro A, Chang EF. A probabilistic map of the human ventral sensorimotor cortex using electrical stimulation. J Neurosurg. 2015 Aug; 123(2):340-9. PMID: 25978714.
      View in: PubMed
    39. Prados MD, Byron SA, Tran NL, Phillips JJ, Molinaro A, Ligon KL, Wen PY, Kuhn JG, Mellinghoff IK, de Groot JF, Colman H, Cloughesy TF, Chang SM, Ryken TC, Tembe WD, Kiefer JA, Berens ME, Craig DW, Carpten JD, Trent JM. Toward precision medicine in glioblastoma: the promise and the challenges. Neuro Oncol. 2015 Aug; 17(8):1051-63. PMID: 25934816; PMCID: PMC4490873.
    40. Reis GF, Pekmezci M, Hansen HM, Rice T, Marshall RE, Molinaro A, Phillips JJ, Vogel H, Wiencke JK, Wrensch MR, Walsh KM, Perry A. CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas. J Neuropathol Exp Neurol. 2015 May; 74(5):442-52. PMID: 25853694; PMCID: PMC4397174.
    41. Hervey-Jumper SL, Li J, Lau D, Molinaro A, Perry DW, Meng L, Berger MS. Awake craniotomy to maximize glioma resection: methods and technical nuances over a 27-year period. J Neurosurg. 2015 Aug; 123(2):325-39. PMID: 25909573.
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    42. Molinaro A, Ferrucci LM, Cartmel B, Loftfield E, Leffell DJ, Bale AE, Mayne ST. Indoor tanning and the MC1R genotype: risk prediction for basal cell carcinoma risk in young people. Am J Epidemiol. 2015 Jun 01; 181(11):908-16. PMID: 25858289; PMCID: PMC4445390.
    43. van Thuijl HF, Mazor T, Johnson BE, Fouse SD, Aihara K, Hong C, Malmström A, Hallbeck M, Heimans JJ, Kloezeman JJ, Stenmark-Askmalm M, Lamfers ML, Saito N, Aburatani H, Mukasa A, Berger MS, Söderkvist P, Taylor BS, Molinaro A, Wesseling P, Reijneveld JC, Chang SM, Ylstra B, Costello JF. Evolution of DNA repair defects during malignant progression of low-grade gliomas after temozolomide treatment. Acta Neuropathol. 2015 Apr; 129(4):597-607. PMID: 25724300; PMCID: PMC4482618.
    44. Chen J, Hackett CS, Zhang S, Song YK, Bell RJ, Molinaro A, Quigley DA, Balmain A, Song JS, Costello JF, Gustafson WC, Van Dyke T, Kwok PY, Khan J, Weiss WA. The genetics of splicing in neuroblastoma. Cancer Discov. 2015 Apr; 5(4):380-95. PMID: 25637275; PMCID: PMC4390477.
    45. Claus EB, Walsh KM, Wiencke JK, Molinaro A, Wiemels JL, Schildkraut JM, Bondy ML, Berger M, Jenkins R, Wrensch M. Survival and low-grade glioma: the emergence of genetic information. Neurosurg Focus. 2015 Jan; 38(1):E6. PMID: 25552286; PMCID: PMC4361022.
    46. Cheng JS, Salinas R, Molinaro A, Chang EF, Kunwar S, Blevins L, Aghi MK. A predictive algorithm for evaluating elevated serum prolactin in patients with a sellar mass. J Clin Neurosci. 2015 Jan; 22(1):155-60. PMID: 25481269.
      View in: PubMed
    47. Englot DJ, Raygor KP, Molinaro A, Garcia PA, Knowlton RC, Auguste KI, Chang EF. Factors associated with failed focal neocortical epilepsy surgery. Neurosurgery. 2014 Dec; 75(6):648-5;discussion 655; quiz 656. PMID: 25181435; PMCID: PMC4393951.
    48. Zhang Y, Ferrucci LM, Cartmel B, Molinaro A, Leffell DJ, Bale AE, Mayne ST. Alcohol intake and early-onset basal cell carcinoma in a case-control study. Br J Dermatol. 2014 Dec; 171(6):1451-7. PMID: 25059635; PMCID: PMC4272627.
    49. Moore CL, Daniels B, Ghita M, Gunabushanam G, Luty S, Molinaro A, Singh D, Gross CP. Accuracy of reduced-dose computed tomography for ureteral stones in emergency department patients. Ann Emerg Med. 2015 Feb; 65(2):189-98.e2. PMID: 25441242.
      View in: PubMed
    50. Wen Q, Jalilian L, Lupo JM, Molinaro A, Chang SM, Clarke J, Prados M, Nelson SJ. Comparison of ADC metrics and their association with outcome for patients with newly diagnosed glioblastoma being treated with radiation therapy, temozolomide, erlotinib and bevacizumab. J Neurooncol. 2015 Jan; 121(2):331-9. PMID: 25351579; PMCID: PMC4311062.
    51. Schoenfeld A, Haas-Kogan DA, Molinaro A, Banerjee A, Nicolaides T, Tihan T, Bollen AW, Gupta N, Mueller S. Pure germinomas of the central nervous system: treatment strategies and outcomes. J Neurooncol. 2014 Dec; 120(3):643-9. PMID: 25189788.
      View in: PubMed
    52. Sun MZ, Ivan ME, Oh MC, Delance AR, Clark AJ, Safaee M, Oh T, Kaur G, Molinaro A, Gupta N, Parsa AT. Effects of adjuvant chemotherapy and radiation on overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014 Nov; 120(2):353-60. PMID: 25106865.
      View in: PubMed
    53. Clarke JL, Molinaro A, Phillips JJ, Butowski NA, Chang SM, Perry A, Costello JF, DeSilva AA, Rabbitt JE, Prados MD. A single-institution phase II trial of radiation, temozolomide, erlotinib, and bevacizumab for initial treatment of glioblastoma. Neuro Oncol. 2014 Jul; 16(7):984-90. PMID: 24637230; PMCID: PMC4057142.
    54. Ferrucci LM, Cartmel B, Molinaro A, Leffell DJ, Bale AE, Mayne ST. Tea, coffee, and caffeine and early-onset basal cell carcinoma in a case-control study. Eur J Cancer Prev. 2014 Jul; 23(4):296-302. PMID: 24841641; PMCID: PMC4059399.
    55. Walsh KM, Codd V, Smirnov IV, Rice T, Decker PA, Hansen HM, Kollmeyer T, Kosel ML, Molinaro A, McCoy LS, Bracci PM, Cabriga BS, Pekmezci M, Zheng S, Wiemels JL, Pico AR, Tihan T, Berger MS, Chang SM, Prados MD, Lachance DH, O'Neill BP, Sicotte H, Eckel-Passow JE, van der Harst P, Wiencke JK, Samani NJ, Jenkins RB, Wrensch MR. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014 Jul; 46(7):731-5. PMID: 24908248; PMCID: PMC4074274.
    56. Han SJ, Rolston JD, Molinaro A, Clarke JL, Prados MD, Chang SM, Berger MS, DeSilva A, Butowski NA. Phase II trial of 7 days on/7 days off temozolmide for recurrent high-grade glioma. Neuro Oncol. 2014 Sep; 16(9):1255-62. PMID: 24670608; PMCID: PMC4136897.
    57. Moore CL, Bomann S, Daniels B, Luty S, Molinaro A, Singh D, Gross CP. Derivation and validation of a clinical prediction rule for uncomplicated ureteral stone--the STONE score: retrospective and prospective observational cohort studies. BMJ. 2014 Mar 26; 348:g2191. PMID: 24671981; PMCID: PMC3966515.
    58. Herbst MK, Rosenberg G, Daniels B, Gross CP, Singh D, Molinaro A, Luty S, Moore CL. Effect of provider experience on clinician-performed ultrasonography for hydronephrosis in patients with suspected renal colic. Ann Emerg Med. 2014 Sep; 64(3):269-76. PMID: 24630203.
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    59. Elkhaled A, Jalbert L, Constantin A, Yoshihara HA, Phillips JJ, Molinaro A, Chang SM, Nelson SJ. Characterization of metabolites in infiltrating gliomas using ex vivo ¹H high-resolution magic angle spinning spectroscopy. NMR Biomed. 2014 May; 27(5):578-93. PMID: 24596146; PMCID: PMC3983568.
    60. Potts MB, Shah JK, Molinaro A, Blevins LS, Tyrrell JB, Kunwar S, Dowd CF, Hetts SW, Aghi MK. Cavernous and inferior petrosal sinus sampling and dynamic magnetic resonance imaging in the preoperative evaluation of Cushing's disease. J Neurooncol. 2014 Feb; 116(3):593-600. PMID: 24398617.
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    61. Sun MZ, Ivan ME, Clark AJ, Oh MC, Delance AR, Oh T, Safaee M, Kaur G, Bloch O, Molinaro A, Gupta N, Parsa AT. Gross total resection improves overall survival in children with choroid plexus carcinoma. J Neurooncol. 2014 Jan; 116(1):179-85. PMID: 24166581.
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    62. Wang DD, Ouyang D, Englot DJ, Rolston JD, Molinaro A, Ward M, Chang EF. Trends in surgical treatment for trigeminal neuralgia in the United States of America from 1988 to 2008. J Clin Neurosci. 2013 Nov; 20(11):1538-45. PMID: 23932422.
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    63. Walsh KM, Rice T, Decker PA, Kosel ML, Kollmeyer T, Hansen HM, Zheng S, McCoy LS, Bracci PM, Anderson E, Hsuang G, Wiemels JL, Pico AR, Smirnov I, Molinaro A, Tihan T, Berger MS, Chang SM, Prados MD, Lachance DH, Sicotte H, Eckel-Passow JE, Wiencke JK, Jenkins RB, Wrensch MR. Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis. Neuro Oncol. 2013 Aug; 15(8):1041-7. PMID: 23733245; PMCID: PMC3714154.
    64. Moore CL, Daniels B, Singh D, Luty S, Molinaro A. Prevalence and clinical importance of alternative causes of symptoms using a renal colic computed tomography protocol in patients with flank or back pain and absence of pyuria. Acad Emerg Med. 2013 May; 20(5):470-8. PMID: 23672361.
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    65. Safaee M, Oh MC, Sughrue ME, Delance AR, Bloch O, Sun M, Kaur G, Molinaro A, Parsa AT. The relative patient benefit of gross total resection in adult choroid plexus papillomas. J Clin Neurosci. 2013 Jun; 20(6):808-12. PMID: 23623658.
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    66. Phillips JJ, Aranda D, Ellison DW, Judkins AR, Croul SE, Brat DJ, Ligon KL, Horbinski C, Venneti S, Zadeh G, Santi M, Zhou S, Appin CL, Sioletic S, Sullivan LM, Martinez-Lage M, Robinson AE, Yong WH, Cloughesy T, Lai A, Phillips HS, Marshall R, Mueller S, Haas-Kogan DA, Molinaro A, Perry A. PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma. Brain Pathol. 2013 Sep; 23(5):565-73. PMID: 23438035; PMCID: PMC3715570.
    67. Mueller S, Bhargava S, Molinaro A, Yang X, Kolkowitz I, Olow A, Wehmeijer N, Orbach S, Chen J, Matthay KK, Haas-Kogan DA. Poly (ADP-Ribose) polymerase inhibitor MK-4827 together with radiation as a novel therapy for metastatic neuroblastoma. Anticancer Res. 2013 Mar; 33(3):755-62. PMID: 23482742; PMCID: PMC3684561.
    68. Lupo JM, Essock-Burns E, Molinaro A, Cha S, Chang SM, Butowski N, Nelson SJ. Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme. Neuro Oncol. 2013 Apr; 15(4):480-9. PMID: 23393208; PMCID: PMC3607266.
    69. Oh MC, Kim JM, Kaur G, Safaee M, Sun MZ, Singh A, Aranda D, Molinaro A, Parsa AT. Prognosis by tumor location in adults with spinal ependymomas. J Neurosurg Spine. 2013 Mar; 18(3):226-35. PMID: 23311515.
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    70. Oh MC, Sayegh ET, Safaee M, Sun MZ, Kaur G, Kim JM, Aranda D, Molinaro A, Gupta N, Parsa AT. Prognosis by tumor location for pediatric spinal cord ependymomas. J Neurosurg Pediatr. 2013 Mar; 11(3):282-8. PMID: 23259510.
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    71. Essock-Burns E, Phillips JJ, Molinaro A, Lupo JM, Cha S, Chang SM, Nelson SJ. Comparison of DSC-MRI post-processing techniques in predicting microvascular histopathology in patients newly diagnosed with GBM. J Magn Reson Imaging. 2013 Aug; 38(2):388-400. PMID: 23281184; PMCID: PMC3711964.
    72. Chakravarti A, Wang M, Robins HI, Lautenschlaeger T, Curran WJ, Brachman DG, Schultz CJ, Choucair A, Dolled-Filhart M, Christiansen J, Gustavson M, Molinaro A, Mischel P, Dicker AP, Bredel M, Mehta M. RTOG 0211: a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients. Int J Radiat Oncol Biol Phys. 2013 Apr 01; 85(5):1206-11. PMID: 23182702; PMCID: PMC4199329.
    73. Engler JR, Robinson AE, Smirnov I, Hodgson JG, Berger MS, Gupta N, James CD, Molinaro A, Phillips JJ. Increased microglia/macrophage gene expression in a subset of adult and pediatric astrocytomas. PLoS One. 2012; 7(8):e43339. PMID: 22937035; PMCID: PMC3425586.
    74. Barajas RF, Phillips JJ, Parvataneni R, Molinaro A, Essock-Burns E, Bourne G, Parsa AT, Aghi MK, McDermott MW, Berger MS, Cha S, Chang SM, Nelson SJ. Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging. Neuro Oncol. 2012 Jul; 14(7):942-54. PMID: 22711606; PMCID: PMC3379808.
    75. Lostritto K, Strawderman RL, Molinaro A. A partitioning deletion/substitution/addition algorithm for creating survival risk groups. Biometrics. 2012 Dec; 68(4):1146-56. PMID: 22519965.
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    76. Hu YL, DeLay M, Jahangiri A, Molinaro A, Rose SD, Carbonell WS, Aghi MK. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res. 2012 Apr 01; 72(7):1773-83. PMID: 22447568; PMCID: PMC3319869.
    77. Baquero MT, Hanna JA, Neumeister V, Cheng H, Molinaro A, Harris LN, Rimm DL. Stathmin expression and its relationship to microtubule-associated protein tau and outcome in breast cancer. Cancer. 2012 Oct 01; 118(19):4660-9. PMID: 22359235; PMCID: PMC3391341.
    78. Lostritto K, Ferrucci LM, Cartmel B, Leffell DJ, Molinaro A, Bale AE, Mayne ST. Lifetime history of indoor tanning in young people: a retrospective assessment of initiation, persistence, and correlates. BMC Public Health. 2012 Feb 10; 12:118. PMID: 22324969; PMCID: PMC3340300.
    79. Ferrucci LM, Cartmel B, Molinaro A, Leffell DJ, Bale AE, Mayne ST. Indoor tanning and risk of early-onset basal cell carcinoma. J Am Acad Dermatol. 2012 Oct; 67(4):552-62. PMID: 22153793; PMCID: PMC3307842.
    80. Ferrucci LM, Cartmel B, Molinaro A, Gordon PB, Leffell DJ, Bale AE, Mayne ST. Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma. J Invest Dermatol. 2012 Apr; 132(4):1272-9. PMID: 22158557; PMCID: PMC3305835.
    81. Baquero MT, Lostritto K, Gustavson MD, Bassi KA, Appia F, Camp RL, Molinaro A, Harris LN, Rimm DL. Evaluation of prognostic and predictive value of microtubule associated protein tau in two independent cohorts. Breast Cancer Res. 2011 Nov 02; 13(5):R85. PMID: 21888627; PMCID: PMC3262195.
    82. Potts MB, Smith JS, Molinaro A, Berger MS. Natural history and surgical management of incidentally discovered low-grade gliomas. J Neurosurg. 2012 Feb; 116(2):365-72. PMID: 21999317.
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    83. Molinaro A, Carriero N, Bjornson R, Hartge P, Rothman N, Chatterjee N. Power of data mining methods to detect genetic associations and interactions. Hum Hered. 2011; 72(2):85-97. PMID: 21934324; PMCID: PMC3222116.
    84. Jahangiri A, Molinaro A, Tarapore PE, Blevins L, Auguste KI, Gupta N, Kunwar S, Aghi MK. Rathke cleft cysts in pediatric patients: presentation, surgical management, and postoperative outcomes. Neurosurg Focus. 2011 Jul; 31(1):E3. PMID: 21721868.
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    85. Tolles J, Bai Y, Baquero M, Harris LN, Rimm DL, Molinaro A. Optimal tumor sampling for immunostaining of biomarkers in breast carcinoma. Breast Cancer Res. 2011 May 18; 13(3):R51. PMID: 21592345; PMCID: PMC3218938.
    86. Bai Y, Tolles J, Cheng H, Siddiqui S, Gopinath A, Pectasides E, Camp RL, Rimm DL, Molinaro A. Quantitative assessment shows loss of antigenic epitopes as a function of pre-analytic variables. Lab Invest. 2011 Aug; 91(8):1253-61. PMID: 21519325; PMCID: PMC3145004.
    87. Kluger HM, Hoyt K, Bacchiocchi A, Mayer T, Kirsch J, Kluger Y, Sznol M, Ariyan S, Molinaro A, Halaban R. Plasma markers for identifying patients with metastatic melanoma. Clin Cancer Res. 2011 Apr 15; 17(8):2417-25. PMID: 21487066; PMCID: PMC3415234.
    88. Martin KD, Naert L, Goldstein LB, Kasl S, Molinaro A, Lichtman JH. Comparing the use of diagnostic imaging and receipt of carotid endarterectomy in elderly black and white stroke patients. J Stroke Cerebrovasc Dis. 2012 Oct; 21(7):600-6. PMID: 21411337; PMCID: PMC3129448.
    89. Pelizzola M, Molinaro A. Methylated DNA immunoprecipitation genome-wide analysis. Methods Mol Biol. 2011; 791:113-23. PMID: 21913075.
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    90. Kluger HM, Dudek AZ, McCann C, Ritacco J, Southard N, Jilaveanu LB, Molinaro A, Sznol M. A phase 2 trial of dasatinib in advanced melanoma. Cancer. 2011 May 15; 117(10):2202-8. PMID: 21523734; PMCID: PMC3116034.
    91. Godshalk SE, Paranjape T, Nallur S, Speed W, Chan E, Molinaro A, Bacchiocchi A, Hoyt K, Tworkoski K, Stern DF, Sznol M, Ariyan S, Lazova R, Halaban R, Kidd KK, Weidhaas JB, Slack FJ. A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma. Oncogene. 2011 Mar 31; 30(13):1542-50. PMID: 21119596; PMCID: PMC3069149.
    92. Kerlikowske K, Molinaro A, Gauthier ML, Berman HK, Waldman F, Bennington J, Sanchez H, Jimenez C, Stewart K, Chew K, Ljung BM, Tlsty TD. Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis. J Natl Cancer Inst. 2010 May 05; 102(9):627-37. PMID: 20427430; PMCID: PMC2864293.
    93. Molinaro A, Lostritto K, van der Laan M. partDSA: deletion/substitution/addition algorithm for partitioning the covariate space in prediction. Bioinformatics. 2010 May 15; 26(10):1357-63. PMID: 20375111; PMCID: PMC2865863.
    94. Molinaro A . STATISTICALBIOINFORMATICS: A GUIDE FOR LIFE AND BIOMEDICAL SCIENCE RESEARCHERS. Ed. Jae K. Lee. Statistical resampling for large screening data analysis such as classical resampling Bootstrapping, Markov chain Monte Carlo, and statistical simulation and validation strategies. 2010.
    95. Gould Rothberg BE, Berger AJ, Molinaro A, Subtil A, Krauthammer MO, Camp RL, Bradley WR, Ariyan S, Kluger HM, Rimm DL. Melanoma prognostic model using tissue microarrays and genetic algorithms. J Clin Oncol. 2009 Dec 01; 27(34):5772-80. PMID: 19884546; PMCID: PMC2792999.
    96. Koga Y, Pelizzola M, Cheng E, Krauthammer M, Sznol M, Ariyan S, Narayan D, Molinaro A, Halaban R, Weissman SM. Genome-wide screen of promoter methylation identifies novel markers in melanoma. Genome Res. 2009 Aug; 19(8):1462-70. PMID: 19491193; PMCID: PMC2720187.
    97. Halaban R, Krauthammer M, Pelizzola M, Cheng E, Kovacs D, Sznol M, Ariyan S, Narayan D, Bacchiocchi A, Molinaro A, Kluger Y, Deng M, Tran N, Zhang W, Picardo M, Enghild JJ. Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications. PLoS One. 2009; 4(2):e4563. PMID: 19234609; PMCID: PMC2642998.
    98. Erickson AH, Wise A, Fleming S, Molinaro A, Teboh-Ewungkem M, Baird M, Lateef Z, and de Pillis L. A preliminary mathematical model of skin dendritic cell trafficking and induction of t-cell immunity. Discrete and Continuous Dynamical Systems - Series B (DCDS-B): Special Issue on Mathematical Biology and Medicine. 2009; 12(2).
    99. Gustavson MD, Molinaro A, Tedeschi G, Camp RL, Rimm DL. AQUA analysis of thymidylate synthase reveals localization to be a key prognostic biomarker in 2 large cohorts of colorectal carcinoma. Arch Pathol Lab Med. 2008 Nov; 132(11):1746-52. PMID: 18976010.
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    100. Giltnane JM, Molinaro A, Cheng H, Robinson A, Turbin D, Gelmon K, Huntsman D, Rimm DL. Comparison of quantitative immunofluorescence with conventional methods for HER2/neu testing with respect to response to trastuzumab therapy in metastatic breast cancer. Arch Pathol Lab Med. 2008 Oct; 132(10):1635-47. PMID: 18834223.
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    101. Pelizzola M, Koga Y, Urban AE, Krauthammer M, Weissman S, Halaban R, Molinaro A. MEDME: an experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment. Genome Res. 2008 Oct; 18(10):1652-9. PMID: 18765822; PMCID: PMC2556264.
    102. Ghosh S, Sullivan CA, Zerkowski MP, Molinaro A, Rimm DL, Camp RL, Chung GG. High levels of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, neuropilin-1) are associated with worse outcome in breast cancer. Hum Pathol. 2008 Dec; 39(12):1835-43. PMID: 18715621; PMCID: PMC2632946.
    103. Kluger HM, Siddiqui SF, Angeletti C, Sznol M, Kelly WK, Molinaro A, Camp RL. Classification of renal cell carcinoma based on expression of VEGF and VEGF receptors in both tumor cells and endothelial cells. Lab Invest. 2008 Sep; 88(9):962-72. PMID: 18626467.
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    104. Petersen ML, Molinaro A, Sinisi SE, van der Laan MJ. Cross-Validated Bagged Learning. J Multivar Anal. 2008 Mar; 25(2):260-266. PMID: 19255599.
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    105. Moeder CB, Giltnane JM, Harigopal M, Molinaro A, Robinson A, Gelmon K, Huntsman D, Camp RL, Rimm DL. Quantitative justification of the change from 10% to 30% for human epidermal growth factor receptor 2 scoring in the American Society of Clinical Oncology/College of American Pathologists guidelines: tumor heterogeneity in breast cancer and its implications for tissue microarray based assessment of outcome. J Clin Oncol. 2007 Dec 01; 25(34):5418-25. PMID: 18048824.
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    106. White SD, Affolter VK, Schultheiss PC, Ball BA, Wessel MT, Kass P, Molinaro A, Bannasch DL, Ihrke PJ. Clinical and pathological findings in a HERDA-affected foal for 1.5 years of life. Vet Dermatol. 2007 Feb; 18(1):36-40. PMID: 17222238.
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    107. Moore LE, Fung ET, McGuire M, Rabkin CC, Molinaro A, Wang Z, Zhang F, Wang J, Yip C, Meng XY, Pfeiffer RM. Evaluation of apolipoprotein A1 and posttranslationally modified forms of transthyretin as biomarkers for ovarian cancer detection in an independent study population. Cancer Epidemiol Biomarkers Prev. 2006 Sep; 15(9):1641-6. PMID: 16985025.
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    108. Hothorn T, Bühlmann P, Dudoit S, Molinaro A, van der Laan MJ. Survival ensembles. Biostatistics. 2006 Jul; 7(3):355-73. PMID: 16344280.
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    109. Molinaro A, Simon R, Pfeiffer RM. Prediction error estimation: a comparison of resampling methods. Bioinformatics. 2005 Aug 01; 21(15):3301-7. PMID: 15905277.
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    110. Molinaro A, Dudoit S, and van der Laan MJ. Tree-based multivariate regression and density estimation with right-censored data. Journal of Multivariate Analysis. 2004; 90(1):154-177.
    111. Kerlikowske K, Molinaro A, Cha I, Ljung BM, Ernster VL, Stewart K, Chew K, Moore DH, Waldman F. Characteristics associated with recurrence among women with ductal carcinoma in situ treated by lumpectomy. J Natl Cancer Inst. 2003 Nov 19; 95(22):1692-702. PMID: 14625260.
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    112. Dudoit S, van der Laan MJ, Keles¸ S, Molinaro A, Sinisi S, and Teng SL. Loss-based estimation with cross-validation: Applications to microarray data analysis and motif finding. SIGKDD Explorations. 2003; 5(2):37-49.
    113. Aust DE, Terdiman JP, Willenbucher RF, Chang CG, Molinaro A, Baretton GB, Loehrs U, and Waldman FM. The apc/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: A mutational analysis. Cancer. 2002; 94(5):1421-7.
    114. Etzell JE, Devries S, Chew K, Florendo C, Molinaro A, Ljung BM, Waldman FM. Loss of chromosome 16q in lobular carcinoma in situ. Hum Pathol. 2001 Mar; 32(3):292-6. PMID: 11274638.
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    115. Aust DE, Terdiman JP, Willenbucher RF, Chew K, Ferrell L, Florendo C, Molinaro A, Baretton GB, Loehrs U, Waldman, FM. Altered Distribution of beta-catenin, and its binding proteins E-cadherin and APC, in Ulcerative Colitis-Related Colorectal Cancers. Modern Pathology. 2001; 14:29-39.
    116. Aust DE, Willenbucher RF, Terdiman JP, Ferrell LD, Chang CG, Moore DH, Molinaro A, Baretton GB, Loehrs U, Waldman FM. Chromosomal Alterations in Ulcerative Colitis-Related and Sporadic Colorectal Cancers by Comparative Genomic Hybridization. Human Pathology. 2000; 31(1):109-114.
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