Qi Wen Fan, MD, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
Address1450 Third Street
San Francisco CA 94158
Phone415-502-1695 ext. 2
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brain-restricted mTOR inhibition with binary pharmacology. Nature. 2022 09; 609(7928):822-828. Zhang Z, Fan Q, Luo X, Lou K, Weiss WA, Shokat KM. PMID: 36104566; PMCID: PMC9492542.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    2. Betacellulin drives therapy resistance in glioblastoma. Neuro Oncol. 2020 04 15; 22(4):457-469. Fan Q, An Z, Wong RA, Luo X, Lu ED, Baldwin A, Mayekar MK, Haderk F, Shokat KM, Bivona TG, Weiss WA. PMID: 31678994; PMCID: PMC7158663.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    3. Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma. Cancer Res. 2020 02 15; 80(4):709-718. Wong RA, Luo X, Lu M, An Z, Haas-Kogan DA, Phillips JJ, Shokat KM, Weiss WA, Fan QW. PMID: 31806641; PMCID: PMC7024655.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    4. DDIS-33. SELECTIVE AND COMPLETE INHIBITION OF mTORC1 BY BI-STERIC mTOR INHIBITORS DRIVES THERAPEUTIC RESPONSE IN GLIOBLASTOMA. Neuro-Oncology. 2019 Nov 11; 21(Supplement_6):vi70-vi70. Fan FQ, Lorenzana LE, Luo LX, Lea LR, Aksoy AO, An AZ, Ozawa OT, Wassarman WD, Shokat SK, Aggen AJ, Smith SJ, Singh SM, Butowski BN, Raleigh RD, Weiss WW. .
      View in: Publisher Site   Mentions:
    5. THER-08. RAPLINK-1 COOPERATES WITH INHIBITORS OF Bcl-2/Bcl-xl TO INDUCE APOPTOSIS IN GLIOBLASTOMA. Neuro-Oncology. 2019 Apr 23; 21(Supplement_2):ii115-ii115. Luo LX, Fan FQ, Shokat SK, Weiss WW. .
      View in: Publisher Site   Mentions:
    6. EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma. Cancer Res. 2018 12 15; 78(24):6785-6794. An Z, Knobbe-Thomsen CB, Wan X, Fan QW, Reifenberger G, Weiss WA. PMID: 30401716; PMCID: PMC6295222.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    7. Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies. Oncogene. 2018 03; 37(12):1561-1575. An Z, Aksoy O, Zheng T, Fan QW, Weiss WA. PMID: 29321659; PMCID: PMC5860944.
      View in: PubMed   Mentions: 243     Fields:    Translation:HumansAnimalsCells
    8. CSIG-42. UNDERSTANDING THE ROLE OF TRANSLATIONAL CONTROL IN MYCN-DRIVEN MEDULLOBLASTOMA. Neuro-Oncology. 2017 Nov 6; 19(suppl_6):vi58-vi58. Aksoy AO, Fan FQ, Shokat SK, Ruggero RD, Weiss WW. .
      View in: Publisher Site   Mentions:
    9. Inhibiting 4EBP1 in Glioblastoma. Clin Cancer Res. 2018 01 01; 24(1):14-21. Fan QW, Nicolaides TP, Weiss WA. PMID: 28696243; PMCID: PMC5754225.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    10. Abstract IA27: A kinase inhibitor targeted to mTORC1 drives regression in glioblastoma. Understanding and Targeting Oncogenic Translation Control in Different Human Cancers. 2017 Mar 15; ia27-ia27. Fan FQ, Aksoy AO, Wong WR, Ilkhanizadeh IS, Novotny NC, Gustafson GW, Tuong TA, Cayanan CG, Simonds SE, Haas-Kogan HD, Phillips PJ, Nicolaides NT, Nicolaides NT, Okaniwa OM, Shokat SK, Weiss WW. .
      View in: Publisher Site   Mentions:
    11. A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma. Cancer Cell. 2017 03 13; 31(3):424-435. Fan Q, Aksoy O, Wong RA, Ilkhanizadeh S, Novotny CJ, Gustafson WC, Truong AY, Cayanan G, Simonds EF, Haas-Kogan D, Phillips JJ, Nicolaides T, Okaniwa M, Shokat KM, Weiss WA. PMID: 28292440; PMCID: PMC5386178.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    12. Combined BRAFV600E and MEK blockade for BRAFV600E-mutant gliomas. J Neurooncol. 2017 02; 131(3):495-505. Zhang J, Yao TW, Hashizume R, Hariono S, Barkovich KJ, Fan QW, Prados M, James CD, Weiss WA, Nicolaides T. PMID: 27848137; PMCID: PMC5560871.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    13. ATPS-94THIRD GENERATION mTOR INHIBITORS IN GLIOBLASTOMA. Neuro-Oncology. 2015 Nov 1; 17(suppl_5):v39-v39. Fan FQ, Wong WR, Novotny NC, Okaniwa OM, Nicolaides NT, Shokat SK, Weiss WW. .
      View in: Publisher Site   Mentions:
    14. Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell Rep. 2014 Nov 06; 9(3):1034-46. Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, Khan J, Balmain A, Fan Q, Weiss WA. PMID: 25437558; PMCID: PMC4251494.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. MTOR KINASE INHIBITORS AND APOPTOSIS IN GLIOBLASTOMA. Neuro-Oncology. 2014 Jul 1; 16(suppl_3):iii31-iii31. Weiss WW, Wong WR, Fan FQ, Ilkhanizadeh IS, Lu LM, Beyer BJ, Dube DN, Forsayeth FJ, Kells KA, Xu XT, Bankiewicz BK, Ducker DG, Feldman FM, Shokat SK. .
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    16. EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell. 2013 Oct 14; 24(4):438-49. Fan QW, Cheng CK, Gustafson WC, Charron E, Zipper P, Wong RA, Chen J, Lau J, Knobbe-Thomsen C, Weller M, Jura N, Reifenberger G, Shokat KM, Weiss WA. PMID: 24135280; PMCID: PMC3819146.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansCells
    17. Abstract 5683: Blockade of glioma proliferation via allosteric inhibition of JAK2. Cancer Chemistry. 2013 Apr 15; 5683-5683. He HK, Qi QQ, Chan CC, Xiao XG, Liu LX, Tucker-Burden TC, Wang WL, Mao MH, Lu LX, McDonald MF, Luo LH, Fan FQ, Weiss WW, Sun SS, Brat BD, Ye YK. .
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    18. Inhibition of PI3K-Akt-mTOR signaling in glioblastoma by mTORC1/2 inhibitors. Methods Mol Biol. 2012; 821:349-59. Fan QW, Weiss WA. PMID: 22125077; PMCID: PMC3402221.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    19. Autophagy and Akt promote survival in glioma. Autophagy. 2011 May; 7(5):536-8. Fan QW, Weiss WA. PMID: 21266843; PMCID: PMC3127214.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    20. Abstract 2314: Erlotinib response in lung- and glioma-derived EGFR alleles: Correlating kinase site occupancy with efficacy. Cancer Chemistry. 2011 Apr 15; 2314-2314. Barkovich BK, Nicolaides NT, Hariono HS, Garske GA, Fan FQ, Shokat SK, Weiss WW. .
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    21. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal. 2010 Nov 09; 3(147):ra81. Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. PMID: 21062993; PMCID: PMC3001107.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimalsCells
    22. Pleiotropic role for MYCN in medulloblastoma. Genes Dev. 2010 May 15; 24(10):1059-72. Swartling FJ, Grimmer MR, Hackett CS, Northcott PA, Fan QW, Goldenberg DD, Lau J, Masic S, Nguyen K, Yakovenko S, Zhe XN, Gilmer HC, Collins R, Nagaoka M, Phillips JJ, Jenkins RB, Tihan T, Vandenberg SR, James CD, Tanaka K, Taylor MD, Weiss WA, Chesler L. PMID: 20478998; PMCID: PMC2867210.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    23. Abstract 1973: Targeting activated alleles of EGFR derived from glioma and lung cancer: Correlating kinase active-site occupancy with efficacy. Experimental and Molecular Therapeutics. 2010 Apr 15; 1973-1973. Nicolaides NT, Barkovich BK, Hariono HS, Garske GA, Fan FQ, Shokat SK, Weiss WW. .
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    24. Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance. Curr Top Microbiol Immunol. 2010; 347:279-96. Fan QW, Weiss WA. PMID: 20535652; PMCID: PMC3012004.
      View in: PubMed   Mentions: 74     Fields:    
    25. EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal. 2009 Jan 27; 2(55):ra4. Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. PMID: 19176518; PMCID: PMC2793677.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansCells
    26. PI3K signaling in glioma--animal models and therapeutic challenges. Brain Pathol. 2009 Jan; 19(1):112-20. Cheng CK, Fan QW, Weiss WA. PMID: 19076776; PMCID: PMC2614703.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    27. Involvement of RhoA, ROCK I and myosin II in inverted orientation of epithelial polarity. EMBO Rep. 2008 Sep; 9(9):923-9. Yu W, Shewan AM, Brakeman P, Eastburn DJ, Datta A, Bryant DM, Fan QW, Weiss WA, Zegers MM, Mostov KE. PMID: 18660750; PMCID: PMC2529350.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    28. A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res. 2007 Sep 01; 67(17):7960-5. Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA. PMID: 17804702; PMCID: PMC2597547.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    29. 39 Glioma. Neurobiology of Disease. 2007 Jan 1; (Cancer1002004):433-444. Persson PA, Fan FQ, Phillips PJ, Weiss WW. .
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    30. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006 May; 9(5):341-9. Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA. PMID: 16697955; PMCID: PMC2925230.
      View in: PubMed   Mentions: 226     Fields:    Translation:HumansAnimalsCells
    31. RNA interference against a glioma-derived allele of EGFR induces blockade at G2M. Oncogene. 2005 Jan 27; 24(5):829-37. Fan QW, Weiss WA. PMID: 15580296.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    32. Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Res. 2003 Dec 15; 63(24):8930-8. Fan QW, Specht KM, Zhang C, Goldenberg DD, Shokat KM, Weiss WA. PMID: 14695210.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    33. Tri-service physician's assistants programs. Mil Med. 1977 May; 142(5):353-6. Robinson HA, Thompson HW. .
      View in: Publisher Site   Mentions:
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