Allan Balmain, PhD

Title(s)Professor, HDF Comprehensive Cancer Ctr
SchoolSchool of Medicine
Address1450 Third St
San Francisco CA 94158
Phone415-502-4180
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Integrating targeted and immunotherapy to treat genetically heterogeneous cancers
    NIH U01CA217864Aug 17, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    Systems genetics analysis of tumor evolution in the mouse
    NIH R35CA210018Jun 1, 2017 - May 31, 2024
    Role: Principal Investigator
    The Oncogenic and Tumor Suppressor Functions of the Kras isoform 4A in vivo
    NIH R01CA184089May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Genetic analysis of ras mutation specificity in skin and lung cancer
    NIH R01CA184510Jan 1, 2015 - Dec 31, 2019
    Role: Principal Investigator
    Science Leadership and Integration
    NIH U01CA141455Sep 1, 2009 - Aug 31, 2015
    Role: Principal Investigator
    Sequenom MassArray System
    NIH S10RR023538Apr 15, 2007 - Apr 14, 2008
    Role: Principal Investigator
    The role of the Kras4A isoform in epithelial carcinogenesis
    NIH R01CA111834Dec 1, 2004 - Jun 30, 2017
    Role: Principal Investigator
    Program Project Grant
    NIH P01AR050440Sep 26, 2003 - Aug 31, 2010
    Role: Principal Investigator
    A Systems Genetics Analysis of Cancer Risk, Progression and Therapeutic Response
    NIH U01CA084244Sep 30, 1999 - Mar 31, 2015
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH P30CA082103Aug 5, 1999 - May 31, 2023
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells. Nat Commun. 2021 07 13; 12(1):4288. Chen WC, To MD, Westcott PMK, Delrosario R, Kim IJ, Philips M, Tran Q, Bollam SR, Goodarzi H, Bayani N, Mirzoeva O, Balmain A. PMID: 34257283.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. The critical roles of somatic mutations and environmental tumor-promoting agents in cancer risk. Nat Genet. 2020 11; 52(11):1139-1143. Balmain A. PMID: 33106632.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    3. The mutational signature profile of known and suspected human carcinogens in mice. Nat Genet. 2020 11; 52(11):1189-1197. Riva L, Pandiri AR, Li YR, Droop A, Hewinson J, Quail MA, Iyer V, Shepherd R, Herbert RA, Campbell PJ, Sills RC, Alexandrov LB, Balmain A, Adams DJ. PMID: 32989322.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    4. Integration of multiple biological contexts reveals principles of synthetic lethality that affect reproducibility. Nat Commun. 2020 05 12; 11(1):2375. Ku AA, Hu HM, Zhao X, Shah KN, Kongara S, Wu D, McCormick F, Balmain A, Bandyopadhyay S. PMID: 32398776.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    5. Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice. Nat Commun. 2020 01 20; 11(1):394. Rose Li Y, Halliwill KD, Adams CJ, Iyer V, Riva L, Mamunur R, Jen KY, Del Rosario R, Fredlund E, Hirst G, Alexandrov LB, Adams D, Balmain A. PMID: 31959748.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsPHPublic Health
    6. KRAS4A directly regulates hexokinase 1. Nature. 2019 12; 576(7787):482-486. Amendola CR, Mahaffey JP, Parker SJ, Ahearn IM, Chen WC, Zhou M, Court H, Shi J, Mendoza SL, Morten MJ, Rothenberg E, Gottlieb E, Wadghiri YZ, Possemato R, Hubbard SR, Balmain A, Kimmelman AC, Philips MR. PMID: 31827279.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    7. Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin. Dev Cell. 2019 11 04; 51(3):326-340.e4. Veniaminova NA, Grachtchouk M, Doane OJ, Peterson JK, Quigley DA, Lull MV, Pyrozhenko DV, Nair RR, Patrick MT, Balmain A, Dlugosz AA, Tsoi LC, Wong SY. PMID: 31564613.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    8. A model for RAS mutation patterns in cancers: finding the sweet spot. Nat Rev Cancer. 2018 12; 18(12):767-777. Li S, Balmain A, Counter CM. PMID: 30420765.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    9. Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis. Nat Cell Biol. 2018 06; 20(6):699-709. Reeves MQ, Kandyba E, Harris S, Del Rosario R, Balmain A. PMID: 29802408.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    10. Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. Nat Genet. 2017 Nov; 49(11):1624-1632. Huang PY, Kandyba E, Jabouille A, Sjolund J, Kumar A, Halliwill K, McCreery M, DelRosario R, Kang HC, Wong CE, Seibler J, Beuger V, Pellegrino M, Sciambi A, Eastburn DJ, Balmain A. PMID: 28945253.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    11. Age, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue. Oncoimmunology. 2017; 6(11):e1356142. Quigley DA, Tahiri A, Lüders T, Riis MH, Balmain A, Børresen-Dale AL, Bukholm I, Kristensen V. PMID: 29147603.
      View in: PubMed   Mentions:
    12. Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer. Genome Med. 2016 08 09; 8(1):83. Halliwill KD, Quigley DA, Kang HC, Del Rosario R, Ginzinger D, Balmain A. PMID: 27506198.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    13. Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer. Cell Rep. 2016 07 26; 16(4):1153-1165. Quigley DA, Kandyba E, Huang P, Halliwill KD, Sjölund J, Pelorosso F, Wong CE, Hirst GL, Wu D, Delrosario R, Kumar A, Balmain A. PMID: 27425619.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    14. K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling. Cell. 2015 Nov 19; 163(5):1237-1251. Wang MT, Holderfield M, Galeas J, Delrosario R, To MD, Balmain A, McCormick F. PMID: 26590425.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    15. Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers. Nat Med. 2015 Dec; 21(12):1514-20. McCreery MQ, Halliwill KD, Chin D, Delrosario R, Hirst G, Vuong P, Jen KY, Hewinson J, Adams DJ, Balmain A. PMID: 26523969.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimals
    16. The Trp53 delta proline (Trp53?P) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Mol Carcinog. 2016 09; 55(9):1387-96. Adams CJ, Yu JS, Mao JH, Jen KY, Costes SV, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl GM, Balmain A. PMID: 26310697.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    17. Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate. Nat Commun. 2015 Apr 27; 6:6706. Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H. PMID: 25913614.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    18. Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14. Front Genet. 2015; 6:67. Letteboer TG, Benzinou M, Merrick CB, Quigley DA, Zhau K, Kim IJ, To MD, Jablons DM, van Amstel JK, Westermann CJ, Giraud S, Dupuis-Girod S, Lesca G, Berg JH, Balmain A, Akhurst RJ. PMID: 25815003.
      View in: PubMed   Mentions:
    19. The genetics of splicing in neuroblastoma. Cancer Discov. 2015 Apr; 5(4):380-95. Chen J, Hackett CS, Zhang S, Song YK, Bell RJ, Molinaro AM, Quigley DA, Balmain A, Song JS, Costello JF, Gustafson WC, Van Dyke T, Kwok PY, Khan J, Weiss WA. PMID: 25637275.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    20. The mutational landscapes of genetic and chemical models of Kras-driven lung cancer. Nature. 2015 Jan 22; 517(7535):489-92. Westcott PM, Halliwill KD, To MD, Rashid M, Rust AG, Keane TM, Delrosario R, Jen KY, Gurley KE, Kemp CJ, Fredlund E, Quigley DA, Adams DJ, Balmain A. PMID: 25363767.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimals
    21. Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53. Mol Cancer Res. 2015 Mar; 13(3):493-501. Quigley D, Silwal-Pandit L, Dannenfelser R, Langerød A, Vollan HK, Vaske C, Siegel JU, Troyanskaya O, Chin SF, Caldas C, Balmain A, Børresen-Dale AL, Kristensen V. PMID: 25351767.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    22. Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell Rep. 2014 Nov 06; 9(3):1034-46. Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, Khan J, Balmain A, Fan Q, Weiss WA. PMID: 25437558.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. Milestones in skin carcinogenesis: the biology of multistage carcinogenesis. J Invest Dermatol. 2014 Oct 10; 134(e1):E2-7. Balmain A, Yuspa SH. PMID: 25302469.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    24. Modeling cutaneous squamous carcinoma development in the mouse. Cold Spring Harb Perspect Med. 2014 Sep 02; 4(9):a013623. Huang PY, Balmain A. PMID: 25183851.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. A multilevel model of postmenopausal breast cancer incidence. Cancer Epidemiol Biomarkers Prev. 2014 Oct; 23(10):2078-92. Hiatt RA, Porco TC, Liu F, Balke K, Balmain A, Barlow J, Braithwaite D, Diez-Roux AV, Kushi LH, Moasser MM, Werb Z, Windham GC, Rehkopf DH. PMID: 25017248.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    26. Identification of Hipk2 as an essential regulator of white fat development. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7373-8. Sjölund J, Pelorosso FG, Quigley DA, DelRosario R, Balmain A. PMID: 24785298.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    27. Cellular reprogramming in skin cancer. Semin Cancer Biol. 2015 Jun; 32:32-9. Song IY, Balmain A. PMID: 24721247.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    28. The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors. Mol Oncol. 2014 Mar; 8(2):273-84. Quigley DA, Fiorito E, Nord S, Van Loo P, Alnæs GG, Fleischer T, Tost J, Moen Vollan HK, Tramm T, Overgaard J, Bukholm IR, Hurtado A, Balmain A, Børresen-Dale AL, Kristensen V. PMID: 24388359.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCellsCTClinical Trials
    29. Keratin 16 regulates innate immunity in response to epidermal barrier breach. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19537-42. Lessard JC, Piña-Paz S, Rotty JD, Hickerson RP, Kaspar RL, Balmain A, Coulombe PA. PMID: 24218583.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    30. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol. 2013 Nov; 132(5):1121-9. Saunders SP, Goh CS, Brown SJ, Palmer CN, Porter RM, Cole C, Campbell LE, Gierlinski M, Barton GJ, Schneider G, Balmain A, Prescott AR, Weidinger S, Baurecht H, Kabesch M, Gieger C, Lee YA, Tavendale R, Mukhopadhyay S, Turner SW, Madhok VB, Sullivan FM, Relton C, Burn J, Meggitt S, Smith CH, Allen MA, Barker JN, Reynolds NJ, Cordell HJ, Irvine AD, McLean WH, Sandilands A, Fallon PG. PMID: 24084074.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    31. Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression. Genes Dev. 2013 Mar 15; 27(6):670-82. Wong CE, Yu JS, Quigley DA, To MD, Jen KY, Huang PY, Del Rosario R, Balmain A. PMID: 23512660.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    32. Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology. J Invest Dermatol. 2013 Jul; 133(7):1907-10. Kang HC, Quigley DA, Kim IJ, Wakabayashi Y, Ferguson-Smith MA, D'Alessandro M, Birgitte Lane E, Akhurst RJ, Goudie DR, Balmain A. PMID: 23358096.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    33. Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes. Clin Cancer Res. 2013 Mar 15; 19(6):1353-62. Nguyen DH, Fredlund E, Zhao W, Perou CM, Balmain A, Mao JH, Barcellos-Hoff MH. PMID: 23339125.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    34. Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun. 2013; 4:1701. Kim IJ, Quigley D, To MD, Pham P, Lin K, Jo B, Jen KY, Raz D, Kim J, Mao JH, Jablons D, Balmain A. PMID: 23591868.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    35. Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice. J Invest Dermatol. 2013 May; 133(5):1311-20. Kang HC, Wakabayashi Y, Jen KY, Mao JH, Zoumpourlis V, Del Rosario R, Balmain A. PMID: 23223138.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    36. Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res. 2012 Jun; 10(6):834-44. Kwon YW, Kim IJ, Wu D, Lu J, Stock WA, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH. PMID: 22513362.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    37. Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility. PLoS One. 2012; 7(2):e31301. Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH. PMID: 22348067.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    38. Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas. Blood. 2012 Jan 19; 119(3):805-9. Jen KY, Song IY, Banta KL, Wu D, Mao JH, Balmain A. PMID: 22117044.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    39. Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer. Mol Cancer Res. 2011 Oct; 9(10):1339-45. To MD, Quigley DA, Mao JH, Del Rosario R, Hsu J, Hodgson G, Jacks T, Balmain A. PMID: 21807965.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    40. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 01; 25(13):1426-38. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. PMID: 21724834.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    41. Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility. Genome Biol. 2011; 12(1):R5. Quigley DA, To MD, Kim IJ, Lin KK, Albertson DG, Sjolund J, Pérez-Losada J, Balmain A. PMID: 21244661.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    42. C/EBPd: friend or foe? a novel role for C/EBPd in metastasis. EMBO J. 2010 Dec 15; 29(24):4063-5. Pelorosso FG, Balmain A. PMID: 21157479.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    43. Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17268-73. Chun MG, Mao JH, Chiu CW, Balmain A, Hanahan D. PMID: 20855625.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    44. Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer. J Clin Oncol. 2010 Aug 10; 28(23):3770-8. Climent J, Perez-Losada J, Quigley DA, Kim IJ, Delrosario R, Jen KY, Bosch A, Lluch A, Mao JH, Balmain A. PMID: 20625127.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    45. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. . 2010 Jan; 152A(1):4-24. Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. PMID: 20014119.
      View in: PubMed   Mentions:
    46. Systems genetics analysis of cancer susceptibility: from mouse models to humans. Nat Rev Genet. 2009 09; 10(9):651-7. Quigley D, Balmain A. PMID: 19636343.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    47. A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell. 2009 Apr 03; 137(1):87-98. Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Bobisse S, Rondina MB, Guzzardo V, Parenti AR, Rosato A, Bicciato S, Balmain A, Piccolo S. PMID: 19345189.
      View in: PubMed   Mentions: 390     Fields:    Translation:HumansAnimalsCells
    48. Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature. 2009 Mar 26; 458(7237):505-8. Quigley DA, To MD, Pérez-Losada J, Pelorosso FG, Mao JH, Nagase H, Ginzinger DG, Balmain A. PMID: 19136944.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    49. Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus. BMC Genomics. 2008 Dec 23; 9:626. Mahler KL, Fleming JL, Dworkin AM, Gladman N, Cho HY, Mao JH, Balmain A, Toland AE. PMID: 19105829.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    50. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science. 2008 Sep 12; 321(5895):1499-502. Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A. PMID: 18787170.
      View in: PubMed   Mentions: 192     Fields:    Translation:HumansAnimalsCells
    51. Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat Genet. 2008 Oct; 40(10):1240-4. To MD, Wong CE, Karnezis AN, Del Rosario R, Di Lauro R, Balmain A. PMID: 18758463.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    52. Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer. Am J Pathol. 2008 Jan; 172(1):236-46. Chiaverotti T, Couto SS, Donjacour A, Mao JH, Nagase H, Cardiff RD, Cunha GR, Balmain A. PMID: 18156212.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimals
    53. HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):13040-5. Wei G, Ku S, Ma GK, Saito S, Tang AA, Zhang J, Mao JH, Appella E, Balmain A, Huang EJ. PMID: 17666529.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    54. Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell. 2007 Feb; 11(2):161-73. Mao JH, Wu D, Perez-Losada J, Jiang T, Li Q, Neve RM, Gray JW, Cai WW, Balmain A. PMID: 17292827.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    55. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature. 2007 Feb 15; 445(7129):761-5. Wakabayashi Y, Mao JH, Brown K, Girardi M, Balmain A. PMID: 17230190.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    56. A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice. Nat Genet. 2006 Aug; 38(8):926-30. To MD, Perez-Losada J, Mao JH, Hsu J, Jacks T, Balmain A. PMID: 16823377.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    57. Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8125-30. Mao JH, Saunier EF, de Koning JP, McKinnon MM, Higgins MN, Nicklas K, Yang HT, Balmain A, Akhurst RJ. PMID: 16702541.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    58. Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition. Cancer Res. 2006 Feb 01; 66(3):1648-57. Lacher MD, Tiirikainen MI, Saunier EF, Christian C, Anders M, Oft M, Balmain A, Akhurst RJ, Korn WM. PMID: 16452224.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    59. Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene. 2005 Nov 24; 24(53):7924-34. Mao JH, Li J, Jiang T, Li Q, Wu D, Perez-Losada J, DelRosario R, Peterson L, Balmain A, Cai WW. PMID: 16116484.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    60. Crosstalk between Pten and Ras signaling pathways in tumor development. . 2005 Sep; 4(9):1185-8. To MD, Perez-Losada J, Mao JH, Balmain A. PMID: 16123588.
      View in: PubMed   Mentions:
    61. p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo. Oncogene. 2005 Aug 18; 24(35):5521-4. Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH. PMID: 16007185.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    62. Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway. Cancer Res. 2005 Aug 01; 65(15):6488-92. Perez-Losada J, Mao JH, Balmain A. PMID: 16061623.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    63. Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis. 2005 Aug; 26(8):1368-73. Ewart-Toland A, Dai Q, Gao YT, Nagase H, Dunlop MG, Farrington SM, Barnetson RA, Anton-Culver H, Peel D, Ziogas A, Lin D, Miao X, Sun T, Ostrander EA, Stanford JL, Langlois M, Chan JM, Yuan J, Harris CC, Bowman ED, Clayman GL, Lippman SM, Lee JJ, Zheng W, Balmain A. PMID: 15802297.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    64. Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res. 2005 Feb; 15(2):302-11. Snijders AM, Nowak NJ, Huey B, Fridlyand J, Law S, Conroy J, Tokuyasu T, Demir K, Chiu R, Mao JH, Jain AN, Jones SJ, Balmain A, Pinkel D, Albertson DG. PMID: 15687294.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    65. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature. 2004 Dec 09; 432(7018):775-9. Mao JH, Perez-Losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI, Brown K, Bryson S, Balmain A. PMID: 15592418.
      View in: PubMed   Mentions: 182     Fields:    Translation:AnimalsCells
    66. Synergistic effects of STK15 gene polymorphisms and endogenous estrogen exposure in the risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2004 Dec; 13(12):2065-70. Dai Q, Cai QY, Shu XO, Ewart-Toland A, Wen WQ, Balmain A, Gao YT, Zheng W. PMID: 15598762.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    67. Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. Genome. 2004 Oct; 47(5):931-46. Hsu SJ, Nagase H, Balmain A. PMID: 15499407.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    68. Genomic segmental polymorphisms in inbred mouse strains. Nat Genet. 2004 Sep; 36(9):952-4. Li J, Jiang T, Mao JH, Balmain A, Peterson L, Harris C, Rao PH, Havlak P, Gibbs R, Cai WW. PMID: 15322544.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    69. Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. Genes Dev. 2004 Aug 01; 18(15):1800-5. Mao JH, To MD, Perez-Losada J, Wu D, Del Rosario R, Balmain A. PMID: 15289454.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    70. A gain of function TGFB1 polymorphism may be associated with late stage prostate cancer. Cancer Epidemiol Biomarkers Prev. 2004 May; 13(5):759-64. Ewart-Toland A, Chan JM, Yuan J, Balmain A, Ma J. PMID: 15159307.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    71. Cancer: dangerous liaisons. Nature. 2004 Mar 18; 428(6980):271-2. Balmain A, Akhurst RJ. PMID: 15029181.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    72. The genetics of cancer susceptibility: from mouse to man. Toxicol Pathol. 2004 Mar-Apr; 32 Suppl 1:26-30. Ewart-Toland A, Balmain A. PMID: 15209400.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    73. Characterizing the protective component of the alphabeta T cell response to transplantable squamous cell carcinoma. J Invest Dermatol. 2004 Mar; 122(3):699-706. Girardi M, Oppenheim D, Glusac EJ, Filler R, Balmain A, Tigelaar RE, Hayday AC. PMID: 15086556.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    74. Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene. 2003 Nov 20; 22(52):8379-85. Mao JH, Wu D, Perez-Losada J, Nagase H, DelRosario R, Balmain A. PMID: 14627978.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    75. Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants. J Virol. 2003 Nov; 77(21):11588-95. Hann B, Balmain A. PMID: 14557644.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    76. Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice. Cancer Res. 2003 Aug 15; 63(16):4849-53. Nagase H, Mao JH, Balmain A. PMID: 12941805.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    77. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet. 2003 Aug; 34(4):403-12. Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A. PMID: 12881723.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansAnimalsCells
    78. Stem-cell hierarchy in skin cancer. Nat Rev Cancer. 2003 Jun; 3(6):434-43. Perez-Losada J, Balmain A. PMID: 12778133.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    79. The genetics and genomics of cancer. Nat Genet. 2003 Mar; 33 Suppl:238-44. Balmain A, Gray J, Ponder B. PMID: 12610533.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimals
    80. Developing novel oncolytic adenoviruses through bioselection. J Virol. 2003 Feb; 77(4):2640-50. Yan W, Kitzes G, Dormishian F, Hawkins L, Sampson-Johannes A, Watanabe J, Holt J, Lee V, Dubensky T, Fattaey A, Hermiston T, Balmain A, Shen Y. PMID: 12552003.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    81. Genomic approaches to identification of tumour-susceptibility genes using mouse models. Curr Opin Genet Dev. 2003 Feb; 13(1):14-9. Mao JH, Balmain A. PMID: 12573430.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    82. Novel approaches to identify low-penetrance cancer susceptibility genes using mouse models. Recent Results Cancer Res. 2003; 163:19-27; discussion 264-6. de Koning JP, Mao JH, Balmain A. PMID: 12903840.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    83. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol. 2002 Jul; 4(7):487-94. Oft M, Akhurst RJ, Balmain A. PMID: 12105419.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    84. High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling. J Biol Chem. 2002 Aug 16; 277(33):29490-5. Psichari E, Balmain A, Plows D, Zoumpourlis V, Pintzas A. PMID: 12039949.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    85. Cancer: new-age tumour suppressors. Nature. 2002 May 16; 417(6886):235-7. Balmain A. PMID: 12015584.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    86. Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays. Nat Biotechnol. 2002 Apr; 20(4):393-6. Cai WW, Mao JH, Chow CW, Damani S, Balmain A, Bradley A. PMID: 11923847.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    87. Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models. Cell. 2002 Jan 25; 108(2):145-52. Balmain A. PMID: 11832205.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    88. Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Mol Cell Biol. 2002 Jan; 22(1):171-81. Bergo MO, Ambroziak P, Gregory C, George A, Otto JC, Kim E, Nagase H, Casey PJ, Balmain A, Young SG. PMID: 11739732.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
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