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Allan Balmain, PhD

TitleProfessor
InstitutionUniversity of California San Francisco
DepartmentHDF Comprehensive Cancer Ctr
Address1450 Third St
San Francisco CA 94158
Phone415-502-4192
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    Collapse Research 
    Collapse Research Activities and Funding
    Integrating targeted and immunotherapy to treat genetically heterogeneous cancers
    NIH/NCI U01CA217864Aug 17, 2017 - Jul 31, 2022
    Role: Co-Principal Investigator
    Systems genetics analysis of tumor evolution in the mouse
    NIH/NCI R35CA210018Jun 1, 2017 - May 31, 2024
    Role: Principal Investigator
    The Oncogenic and Tumor Suppressor Functions of the Kras isoform 4A in vivo
    NIH/NCI R01CA184089May 1, 2015 - Apr 30, 2020
    Role: Principal Investigator
    Genetic analysis of ras mutation specificity in skin and lung cancer
    NIH/NCI R01CA184510Jan 1, 2015 - Dec 31, 2019
    Role: Principal Investigator
    Science Leadership and Integration
    NIH/NCI U01CA141455Sep 1, 2009 - Aug 31, 2014
    Role: Principal Investigator
    Sequenom MassArray System
    NIH/NCRR S10RR023538Apr 15, 2007 - Apr 14, 2008
    Role: Principal Investigator
    The role of the Kras4A isoform in epithelial carcinogenesis
    NIH/NCI R01CA111834Dec 1, 2004 - Jun 30, 2017
    Role: Principal Investigator
    Program Project Grant
    NIH/NIAMS P01AR050440Sep 26, 2003 - Aug 31, 2010
    Role: Principal Investigator
    A Systems Genetics Analysis of Cancer Risk, Progression and Therapeutic Response
    NIH/NCI U01CA084244Sep 30, 1999 - Mar 31, 2014
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH/NCI P30CA082103Aug 5, 1999 - May 31, 2018
    Role: Co-Investigator

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Reeves MQ, Kandyba E, Harris S, Del Rosario R, Balmain A. Multicolour lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis. Nat Cell Biol. 2018 Jun; 20(6):699-709. PMID: 29802408.
      View in: PubMed
    2. Huang PY, Kandyba E, Jabouille A, Sjolund J, Kumar A, Halliwill K, McCreery M, DelRosario R, Kang HC, Wong CE, Seibler J, Beuger V, Pellegrino M, Sciambi A, Eastburn DJ, Balmain A. Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma. Nat Genet. 2017 Nov; 49(11):1624-1632. PMID: 28945253.
      View in: PubMed
    3. Quigley DA, Tahiri A, Lüders T, Riis MH, Balmain A, Børresen-Dale AL, Bukholm I, Kristensen V. Age, estrogen, and immune response in breast adenocarcinoma and adjacent normal tissue. Oncoimmunology. 2017; 6(11):e1356142. PMID: 29147603.
      View in: PubMed
    4. Halliwill KD, Quigley DA, Kang HC, Del Rosario R, Ginzinger D, Balmain A. Panx3 links body mass index and tumorigenesis in a genetically heterogeneous mouse model of carcinogen-induced cancer. Genome Med. 2016 08 09; 8(1):83. PMID: 27506198; PMCID: PMC4977876.
    5. Quigley DA, Kandyba E, Huang P, Halliwill KD, Sjölund J, Pelorosso F, Wong CE, Hirst GL, Wu D, Delrosario R, Kumar A, Balmain A. Gene Expression Architecture of Mouse Dorsal and Tail Skin Reveals Functional Differences in Inflammation and Cancer. Cell Rep. 2016 07 26; 16(4):1153-1165. PMID: 27425619.
      View in: PubMed
    6. Wang MT, Holderfield M, Galeas J, Delrosario R, To MD, Balmain A, McCormick F. K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling. Cell. 2015 Nov 19; 163(5):1237-1251. PMID: 26590425.
      View in: PubMed
    7. McCreery MQ, Halliwill KD, Chin D, Delrosario R, Hirst G, Vuong P, Jen KY, Hewinson J, Adams DJ, Balmain A. Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers. Nat Med. 2015 Dec; 21(12):1514-20. PMID: 26523969.
      View in: PubMed
    8. Adams CJ, Yu JS, Mao JH, Jen KY, Costes SV, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl GM, Balmain A. The Trp53 delta proline (Trp53?P) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Mol Carcinog. 2016 09; 55(9):1387-96. PMID: 26310697; PMCID: PMC4891300 [Available on 09/01/17].
    9. Hiraoka K, Inoue T, Taylor RD, Watanabe T, Koshikawa N, Yoda H, Shinohara K, Takatori A, Sugimoto H, Maru Y, Denda T, Fujiwara K, Balmain A, Ozaki T, Bando T, Sugiyama H, Nagase H. Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate. Nat Commun. 2015 Apr 27; 6:6706. PMID: 25913614.
      View in: PubMed
    10. Letteboer TG, Benzinou M, Merrick CB, Quigley DA, Zhau K, Kim IJ, To MD, Jablons DM, van Amstel JK, Westermann CJ, Giraud S, Dupuis-Girod S, Lesca G, Berg JH, Balmain A, Akhurst RJ. Genetic variation in the functional ENG allele inherited from the non-affected parent associates with presence of pulmonary arteriovenous malformation in hereditary hemorrhagic telangiectasia 1 (HHT1) and may influence expression of PTPN14. Front Genet. 2015; 6:67. PMID: 25815003; PMCID: PMC4357294.
    11. Chen J, Hackett CS, Zhang S, Song YK, Bell RJ, Molinaro AM, Quigley DA, Balmain A, Song JS, Costello JF, Gustafson WC, Van Dyke T, Kwok PY, Khan J, Weiss WA. The genetics of splicing in neuroblastoma. Cancer Discov. 2015 Apr; 5(4):380-95. PMID: 25637275; PMCID: PMC4390477.
    12. Westcott PM, Halliwill KD, To MD, Rashid M, Rust AG, Keane TM, Delrosario R, Jen KY, Gurley KE, Kemp CJ, Fredlund E, Quigley DA, Adams DJ, Balmain A. The mutational landscapes of genetic and chemical models of Kras-driven lung cancer. Nature. 2015 Jan 22; 517(7535):489-92. PMID: 25363767.
      View in: PubMed
    13. Quigley D, Silwal-Pandit L, Dannenfelser R, Langerød A, Vollan HK, Vaske C, Siegel JU, Troyanskaya O, Chin SF, Caldas C, Balmain A, Børresen-Dale AL, Kristensen V. Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53. Mol Cancer Res. 2015 Mar; 13(3):493-501. PMID: 25351767; PMCID: PMC4465579.
    14. Hackett CS, Quigley DA, Wong RA, Chen J, Cheng C, Song YK, Wei JS, Pawlikowska L, Bao Y, Goldenberg DD, Nguyen K, Gustafson WC, Rallapalli SK, Cho YJ, Cook JM, Kozlov S, Mao JH, Van Dyke T, Kwok PY, Khan J, Balmain A, Fan Q, Weiss WA. Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma. Cell Rep. 2014 Nov 06; 9(3):1034-46. PMID: 25437558; PMCID: PMC4251494.
    15. Balmain A, Yuspa SH. Milestones in skin carcinogenesis: the biology of multistage carcinogenesis. J Invest Dermatol. 2014 Oct 10; 134(e1):E2-7. PMID: 25302469.
      View in: PubMed
    16. Huang PY, Balmain A. Modeling cutaneous squamous carcinoma development in the mouse. Cold Spring Harb Perspect Med. 2014 Sep 02; 4(9):a013623. PMID: 25183851; PMCID: PMC4143107.
    17. Hiatt RA, Porco TC, Liu F, Balke K, Balmain A, Barlow J, Braithwaite D, Diez-Roux AV, Kushi LH, Moasser MM, Werb Z, Windham GC, Rehkopf DH. A multilevel model of postmenopausal breast cancer incidence. Cancer Epidemiol Biomarkers Prev. 2014 Oct; 23(10):2078-92. PMID: 25017248.
      View in: PubMed
    18. Sjölund J, Pelorosso FG, Quigley DA, DelRosario R, Balmain A. Identification of Hipk2 as an essential regulator of white fat development. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7373-8. PMID: 24785298; PMCID: PMC4034214.
    19. Song IY, Balmain A. Cellular reprogramming in skin cancer. Semin Cancer Biol. 2015 Jun; 32:32-9. PMID: 24721247; PMCID: PMC4467683.
    20. Quigley DA, Fiorito E, Nord S, Van Loo P, Alnæs GG, Fleischer T, Tost J, Moen Vollan HK, Tramm T, Overgaard J, Bukholm IR, Hurtado A, Balmain A, Børresen-Dale AL, Kristensen V. The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors. Mol Oncol. 2014 Mar; 8(2):273-84. PMID: 24388359; PMCID: PMC3964809.
    21. Lessard JC, Piña-Paz S, Rotty JD, Hickerson RP, Kaspar RL, Balmain A, Coulombe PA. Keratin 16 regulates innate immunity in response to epidermal barrier breach. Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48):19537-42. PMID: 24218583; PMCID: PMC3845144.
    22. Saunders SP, Goh CS, Brown SJ, Palmer CN, Porter RM, Cole C, Campbell LE, Gierlinski M, Barton GJ, Schneider G, Balmain A, Prescott AR, Weidinger S, Baurecht H, Kabesch M, Gieger C, Lee YA, Tavendale R, Mukhopadhyay S, Turner SW, Madhok VB, Sullivan FM, Relton C, Burn J, Meggitt S, Smith CH, Allen MA, Barker JN, Reynolds NJ, Cordell HJ, Irvine AD, McLean WH, Sandilands A, Fallon PG. Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J Allergy Clin Immunol. 2013 Nov; 132(5):1121-9. PMID: 24084074.
      View in: PubMed
    23. Wong CE, Yu JS, Quigley DA, To MD, Jen KY, Huang PY, Del Rosario R, Balmain A. Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression. Genes Dev. 2013 Mar 15; 27(6):670-82. PMID: 23512660; PMCID: PMC3613613.
    24. Kang HC, Quigley DA, Kim IJ, Wakabayashi Y, Ferguson-Smith MA, D'Alessandro M, Birgitte Lane E, Akhurst RJ, Goudie DR, Balmain A. Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology. J Invest Dermatol. 2013 Jul; 133(7):1907-10. PMID: 23358096; PMCID: PMC3664264.
    25. Nguyen DH, Fredlund E, Zhao W, Perou CM, Balmain A, Mao JH, Barcellos-Hoff MH. Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes. Clin Cancer Res. 2013 Mar 15; 19(6):1353-62. PMID: 23339125; PMCID: PMC3732211.
    26. Kim IJ, Quigley D, To MD, Pham P, Lin K, Jo B, Jen KY, Raz D, Kim J, Mao JH, Jablons D, Balmain A. Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas. Nat Commun. 2013; 4:1701. PMID: 23591868; PMCID: PMC4450149.
    27. Kang HC, Wakabayashi Y, Jen KY, Mao JH, Zoumpourlis V, Del Rosario R, Balmain A. Ptch1 overexpression drives skin carcinogenesis and developmental defects in K14Ptch(FVB) mice. J Invest Dermatol. 2013 May; 133(5):1311-20. PMID: 23223138; PMCID: PMC3610826.
    28. Kwon YW, Kim IJ, Wu D, Lu J, Stock WA, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH. Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res. 2012 Jun; 10(6):834-44. PMID: 22513362; PMCID: PMC3388112.
    29. Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH. Allele-specific deletions in mouse tumors identify Fbxw7 as germline modifier of tumor susceptibility. PLoS One. 2012; 7(2):e31301. PMID: 22348067; PMCID: PMC3278431.
    30. Jen KY, Song IY, Banta KL, Wu D, Mao JH, Balmain A. Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas. Blood. 2012 Jan 19; 119(3):805-9. PMID: 22117044; PMCID: PMC3265203.
    31. To MD, Quigley DA, Mao JH, Del Rosario R, Hsu J, Hodgson G, Jacks T, Balmain A. Progressive genomic instability in the FVB/Kras(LA2) mouse model of lung cancer. Mol Cancer Res. 2011 Oct; 9(10):1339-45. PMID: 21807965; PMCID: PMC3196775.
    32. Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev. 2011 Jul 01; 25(13):1426-38. PMID: 21724834; PMCID: PMC3134085.
    33. Quigley DA, To MD, Kim IJ, Lin KK, Albertson DG, Sjolund J, Pérez-Losada J, Balmain A. Network analysis of skin tumor progression identifies a rewired genetic architecture affecting inflammation and tumor susceptibility. Genome Biol. 2011; 12(1):R5. PMID: 21244661; PMCID: PMC3091303.
    34. Pelorosso FG, Balmain A. C/EBPd: friend or foe? a novel role for C/EBPd in metastasis. EMBO J. 2010 Dec 15; 29(24):4063-5. PMID: 21157479; PMCID: PMC3018802.
    35. Chun MG, Mao JH, Chiu CW, Balmain A, Hanahan D. Polymorphic genetic control of tumor invasion in a mouse model of pancreatic neuroendocrine carcinogenesis. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17268-73. PMID: 20855625; PMCID: PMC2951397.
    36. Climent J, Perez-Losada J, Quigley DA, Kim IJ, Delrosario R, Jen KY, Bosch A, Lluch A, Mao JH, Balmain A. Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer. J Clin Oncol. 2010 Aug 10; 28(23):3770-8. PMID: 20625127; PMCID: PMC2917310.
    37. Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A. 2010 Jan; 152A(1):4-24. PMID: 20014119; PMCID: PMC4051786.
    38. Quigley D, Balmain A. Systems genetics analysis of cancer susceptibility: from mouse models to humans. Nat Rev Genet. 2009 09; 10(9):651-7. PMID: 19636343.
      View in: PubMed
    39. Adorno M, Cordenonsi M, Montagner M, Dupont S, Wong C, Hann B, Solari A, Bobisse S, Rondina MB, Guzzardo V, Parenti AR, Rosato A, Bicciato S, Balmain A, Piccolo S. A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis. Cell. 2009 Apr 03; 137(1):87-98. PMID: 19345189.
      View in: PubMed
    40. Quigley DA, To MD, Pérez-Losada J, Pelorosso FG, Mao JH, Nagase H, Ginzinger DG, Balmain A. Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature. 2009 Mar 26; 458(7237):505-8. PMID: 19136944; PMCID: PMC4460995.
    41. Mahler KL, Fleming JL, Dworkin AM, Gladman N, Cho HY, Mao JH, Balmain A, Toland AE. Sequence divergence of Mus spretus and Mus musculus across a skin cancer susceptibility locus. BMC Genomics. 2008 Dec 23; 9:626. PMID: 19105829; PMCID: PMC2628916.
    42. Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science. 2008 Sep 12; 321(5895):1499-502. PMID: 18787170; PMCID: PMC2849753.
    43. To MD, Wong CE, Karnezis AN, Del Rosario R, Di Lauro R, Balmain A. Kras regulatory elements and exon 4A determine mutation specificity in lung cancer. Nat Genet. 2008 Oct; 40(10):1240-4. PMID: 18758463; PMCID: PMC2654781.
    44. Chiaverotti T, Couto SS, Donjacour A, Mao JH, Nagase H, Cardiff RD, Cunha GR, Balmain A. Dissociation of epithelial and neuroendocrine carcinoma lineages in the transgenic adenocarcinoma of mouse prostate model of prostate cancer. Am J Pathol. 2008 Jan; 172(1):236-46. PMID: 18156212; PMCID: PMC2189611.
    45. Wei G, Ku S, Ma GK, Saito S, Tang AA, Zhang J, Mao JH, Appella E, Balmain A, Huang EJ. HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis. Proc Natl Acad Sci U S A. 2007 Aug 07; 104(32):13040-5. PMID: 17666529; PMCID: PMC1936219.
    46. Mao JH, Wu D, Perez-Losada J, Jiang T, Li Q, Neve RM, Gray JW, Cai WW, Balmain A. Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell. 2007 Feb; 11(2):161-73. PMID: 17292827; PMCID: PMC2730519.
    47. Wakabayashi Y, Mao JH, Brown K, Girardi M, Balmain A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature. 2007 Feb 15; 445(7129):761-5. PMID: 17230190.
      View in: PubMed
    48. To MD, Perez-Losada J, Mao JH, Hsu J, Jacks T, Balmain A. A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice. Nat Genet. 2006 Aug; 38(8):926-30. PMID: 16823377; PMCID: PMC4461000.
    49. Mao JH, Saunier EF, de Koning JP, McKinnon MM, Higgins MN, Nicklas K, Yang HT, Balmain A, Akhurst RJ. Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8125-30. PMID: 16702541; PMCID: PMC1472440.
    50. Lacher MD, Tiirikainen MI, Saunier EF, Christian C, Anders M, Oft M, Balmain A, Akhurst RJ, Korn WM. Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition. Cancer Res. 2006 Feb 01; 66(3):1648-57. PMID: 16452224.
      View in: PubMed
    51. Mao JH, Li J, Jiang T, Li Q, Wu D, Perez-Losada J, DelRosario R, Peterson L, Balmain A, Cai WW. Genomic instability in radiation-induced mouse lymphoma from p53 heterozygous mice. Oncogene. 2005 Nov 24; 24(53):7924-34. PMID: 16116484.
      View in: PubMed
    52. To MD, Perez-Losada J, Mao JH, Balmain A. Crosstalk between Pten and Ras signaling pathways in tumor development. Cell Cycle. 2005 Sep; 4(9):1185-8. PMID: 16123588.
      View in: PubMed
    53. Perez-Losada J, Wu D, DelRosario R, Balmain A, Mao JH. p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo. Oncogene. 2005 Aug 18; 24(35):5521-4. PMID: 16007185.
      View in: PubMed
    54. Perez-Losada J, Mao JH, Balmain A. Control of genomic instability and epithelial tumor development by the p53-Fbxw7/Cdc4 pathway. Cancer Res. 2005 Aug 01; 65(15):6488-92. PMID: 16061623.
      View in: PubMed
    55. Ewart-Toland A, Dai Q, Gao YT, Nagase H, Dunlop MG, Farrington SM, Barnetson RA, Anton-Culver H, Peel D, Ziogas A, Lin D, Miao X, Sun T, Ostrander EA, Stanford JL, Langlois M, Chan JM, Yuan J, Harris CC, Bowman ED, Clayman GL, Lippman SM, Lee JJ, Zheng W, Balmain A. Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis. 2005 Aug; 26(8):1368-73. PMID: 15802297.
      View in: PubMed
    56. Snijders AM, Nowak NJ, Huey B, Fridlyand J, Law S, Conroy J, Tokuyasu T, Demir K, Chiu R, Mao JH, Jain AN, Jones SJ, Balmain A, Pinkel D, Albertson DG. Mapping segmental and sequence variations among laboratory mice using BAC array CGH. Genome Res. 2005 Feb; 15(2):302-11. PMID: 15687294; PMCID: PMC546532.
    57. Mao JH, Perez-Losada J, Wu D, Delrosario R, Tsunematsu R, Nakayama KI, Brown K, Bryson S, Balmain A. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature. 2004 Dec 09; 432(7018):775-9. PMID: 15592418.
      View in: PubMed
    58. Dai Q, Cai QY, Shu XO, Ewart-Toland A, Wen WQ, Balmain A, Gao YT, Zheng W. Synergistic effects of STK15 gene polymorphisms and endogenous estrogen exposure in the risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2004 Dec; 13(12):2065-70. PMID: 15598762.
      View in: PubMed
    59. Hsu SJ, Nagase H, Balmain A. Identification of Fetuin-B as a member of a cystatin-like gene family on mouse chromosome 16 with tumor suppressor activity. Genome. 2004 Oct; 47(5):931-46. PMID: 15499407.
      View in: PubMed
    60. Li J, Jiang T, Mao JH, Balmain A, Peterson L, Harris C, Rao PH, Havlak P, Gibbs R, Cai WW. Genomic segmental polymorphisms in inbred mouse strains. Nat Genet. 2004 Sep; 36(9):952-4. PMID: 15322544.
      View in: PubMed
    61. Mao JH, To MD, Perez-Losada J, Wu D, Del Rosario R, Balmain A. Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression. Genes Dev. 2004 Aug 01; 18(15):1800-5. PMID: 15289454; PMCID: PMC517400.
    62. Ewart-Toland A, Chan JM, Yuan J, Balmain A, Ma J. A gain of function TGFB1 polymorphism may be associated with late stage prostate cancer. Cancer Epidemiol Biomarkers Prev. 2004 May; 13(5):759-64. PMID: 15159307.
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    63. Balmain A, Akhurst RJ. Cancer: dangerous liaisons. Nature. 2004 Mar 18; 428(6980):271-2. PMID: 15029181.
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    64. Girardi M, Oppenheim D, Glusac EJ, Filler R, Balmain A, Tigelaar RE, Hayday AC. Characterizing the protective component of the alphabeta T cell response to transplantable squamous cell carcinoma. J Invest Dermatol. 2004 Mar; 122(3):699-706. PMID: 15086556.
      View in: PubMed
    65. Ewart-Toland A, Balmain A. The genetics of cancer susceptibility: from mouse to man. Toxicol Pathol. 2004 Mar-Apr; 32 Suppl 1:26-30. PMID: 15209400.
      View in: PubMed
    66. Mao JH, Wu D, Perez-Losada J, Nagase H, DelRosario R, Balmain A. Genetic interactions between Pten and p53 in radiation-induced lymphoma development. Oncogene. 2003 Nov 20; 22(52):8379-85. PMID: 14627978.
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    67. Hann B, Balmain A. Replication of an E1B 55-kilodalton protein-deficient adenovirus (ONYX-015) is restored by gain-of-function rather than loss-of-function p53 mutants. J Virol. 2003 Nov; 77(21):11588-95. PMID: 14557644; PMCID: PMC229311.
    68. Nagase H, Mao JH, Balmain A. Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice. Cancer Res. 2003 Aug 15; 63(16):4849-53. PMID: 12941805.
      View in: PubMed
    69. Ewart-Toland A, Briassouli P, de Koning JP, Mao JH, Yuan J, Chan F, MacCarthy-Morrogh L, Ponder BA, Nagase H, Burn J, Ball S, Almeida M, Linardopoulos S, Balmain A. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Nat Genet. 2003 Aug; 34(4):403-12. PMID: 12881723.
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    70. Perez-Losada J, Balmain A. Stem-cell hierarchy in skin cancer. Nat Rev Cancer. 2003 Jun; 3(6):434-43. PMID: 12778133.
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    71. Balmain A, Gray J, Ponder B. The genetics and genomics of cancer. Nat Genet. 2003 Mar; 33 Suppl:238-44. PMID: 12610533.
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    72. Mao JH, Balmain A. Genomic approaches to identification of tumour-susceptibility genes using mouse models. Curr Opin Genet Dev. 2003 Feb; 13(1):14-9. PMID: 12573430.
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    73. Yan W, Kitzes G, Dormishian F, Hawkins L, Sampson-Johannes A, Watanabe J, Holt J, Lee V, Dubensky T, Fattaey A, Hermiston T, Balmain A, Shen Y. Developing novel oncolytic adenoviruses through bioselection. J Virol. 2003 Feb; 77(4):2640-50. PMID: 12552003; PMCID: PMC141112.
    74. de Koning JP, Mao JH, Balmain A. Novel approaches to identify low-penetrance cancer susceptibility genes using mouse models. Recent Results Cancer Res. 2003; 163:19-27; discussion 264-6. PMID: 12903840.
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    75. Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol. 2002 Jul; 4(7):487-94. PMID: 12105419.
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    76. Psichari E, Balmain A, Plows D, Zoumpourlis V, Pintzas A. High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling. J Biol Chem. 2002 Aug 16; 277(33):29490-5. PMID: 12039949.
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    77. Balmain A. Cancer: new-age tumour suppressors. Nature. 2002 May 16; 417(6886):235-7. PMID: 12015584.
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    78. Cai WW, Mao JH, Chow CW, Damani S, Balmain A, Bradley A. Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays. Nat Biotechnol. 2002 Apr; 20(4):393-6. PMID: 11923847.
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    79. Balmain A. Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models. Cell. 2002 Jan 25; 108(2):145-52. PMID: 11832205.
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