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David Solomon, MD, PhD

TitleAssistant Professor
InstitutionUniversity of California San Francisco
DepartmentPathology
Address513 Parnassus Ave
San Francisco CA 94143
Phone415-514-9761
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    Collapse Biography 
    Collapse Education and Training
    College of William and MaryB.S. Molecular Cell Biology, Chemistry2002
    Georgetown University School of MedicineM.D., Ph.D. Tumor Biology2012
    University of California, San FranciscoResidency in Anatomic Pathology2015
    University of California, San FranciscoFellowship in Neuropathology2016
    Collapse Awards and Honors
    NIH Director's Early Independence Award2015  - 2020High-Risk, High-Reward Research Program supported by the NIH Common Fund
    Harold M. Weintraub Graduate Student Award2012one of twelve recipients at the Weintraub Symposium, Fred Hutchinson Cancer Research Center, Seattle
    Future Leaders in Basic Cancer Research2012one of four recipients at the 2012 American Association for Cancer Research Annual Meeting, Chicago
    Career Development Research Award2015  - 2016UCSF Brain Tumor SPORE
    Stowell-Orbison Award2014best abstract presentation by a trainee at Annual Meeting of the US & Canada Academy of Pathology
    Young Investigator Award2014best abstract presentation by a trainee, International Society of Bone and Soft Tissue Pathology
    Stowell-Orbison Award2013best abstract presentation by a trainee at Annual Meeting of the US & Canada Academy of Pathology
    Julius Krevans Award2013outstanding clinical service by a UCSF Pathology Intern, San Francisco General Hospital
    Clifford C. Kaslow Research Achievement Award2011Department of Medicine, Georgetown University Medical Center (2008 and 2011)
    Robert Dickson Graduate Prize2011recipient of inaugural award, Lombardi Cancer Center, Georgetown University Medical Center
    Strauss Physician Scientist Training Fellowship2004  - 2012Georgetown University School of Medicine
    Howard Hughes Medical Institute student research grants2000  - 2002College of William and Mary Undergraduate Science Education and Research Program
    William and Mary Monroe Scholar1998  - 2002College of William and Mary, Williamsburg, VA

    Collapse Overview 
    Collapse Overview
    I am a neuropathologist and cancer researcher at the University of California, San Francisco with a dedicated interest in the genetic alterations that drive cancer development. We have recently discovered frequent inactivating mutations of the cohesin complex gene STAG2 in glioblastoma, urothelial bladder cancer, Ewing sarcoma, and acute myeloid leukemia (AML), which define molecular subgroups of these tumors with distinct clinical outcomes. The cohesin complex is responsible for sister chromatid cohesion following DNA replication and helps ensure faithful chromosome segregation during mitosis, but has also been implicated in additional cellular processes such as regulation of chromatin architecture and gene transcription. Our studies in glioblastoma demonstrated that STAG2 mutations were a direct cause of chromosomal instability and aneuploidy; however, cohesin gene alterations in urothelial carcinoma and AML have been identified primarily in near-diploid tumors, suggesting alternative mechanisms by which cohesin inactivation drives oncogenesis. Using a newly generated conditional STAG2 knockout mouse and isogenic sets of STAG2 proficient and deficient cancer cell lines, we are currently working to determine the function of STAG2 in mouse development and tumorigenesis and to identify therapeutic vulnerabilities in the many cancers harboring cohesin gene alterations. Other ongoing studies in the Solomon Lab include genomic characterization of brain tumor variants such as chordoid gliomas, choroid plexus tumors, and pineal parenchymal tumors.


    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pekmezci M, Villanueva-Meyer JE, Goode B, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Chamyan G, Maher OM, Khatib Z, Kleinschmidt-DeMasters BK, Samuel D, Mueller S, Banerjee A, Clarke JL, Cooney T, Torkildson J, Gupta N, Theodosopoulos P, Chang EF, Berger M, Bollen AW, Perry A, Tihan T, Solomon D. The genetic landscape of ganglioglioma. Acta Neuropathol Commun. 2018 Jun 07; 6(1):47. PMID: 29880043.
      View in: PubMed
    2. North JP, Golovato J, Vaske CJ, Sanborn JZ, Nguyen A, Wu W, Goode B, Stevers M, McMullen K, Perez White BE, Collisson EA, Bloomer M, Solomon D, Benz SC, Cho RJ. Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma. Nat Commun. 2018 May 14; 9(1):1894. PMID: 29760388.
      View in: PubMed
    3. Waszak SM, Northcott PA, Buchhalter I, Robinson GW, Sutter C, Groebner S, Grund KB, Brugières L, Jones DTW, Pajtler KW, Morrissy AS, Kool M, Sturm D, Chavez L, Ernst A, Brabetz S, Hain M, Zichner T, Segura-Wang M, Weischenfeldt J, Rausch T, Mardin BR, Zhou X, Baciu C, Lawerenz C, Chan JA, Varlet P, Guerrini-Rousseau L, Fults DW, Grajkowska W, Hauser P, Jabado N, Ra YS, Zitterbart K, Shringarpure SS, De La Vega FM, Bustamante CD, Ng HK, Perry A, MacDonald TJ, Hernáiz Driever P, Bendel AE, Bowers DC, McCowage G, Chintagumpala MM, Cohn R, Hassall T, Fleischhack G, Eggen T, Wesenberg F, Feychting M, Lannering B, Schüz J, Johansen C, Andersen TV, Röösli M, Kuehni CE, Grotzer M, Kjaerheim K, Monoranu CM, Archer TC, Duke E, Pomeroy SL, Shelagh R, Frank S, Sumerauer D, Scheurlen W, Ryzhova MV, Milde T, Kratz CP, Samuel D, Zhang J, Solomon D, Marra M, Eils R, Bartram CR, von Hoff K, Rutkowski S, Ramaswamy V, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Malkin D, Gajjar A, Korbel JO, Pfister SM. Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. Lancet Oncol. 2018 May 09. PMID: 29753700.
      View in: PubMed
    4. Ding S, Diep J, Feng N, Ren L, Li B, Ooi YS, Wang X, Brulois KF, Yasukawa LL, Li X, Kuo CJ, Solomon D, Carette JE, Greenberg HB. STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection. Nat Commun. 2018 Apr 16; 9(1):1485. PMID: 29662124.
      View in: PubMed
    5. Hayes J, Yu Y, Jalbert LE, Mazor T, Jones LE, Wood MD, Walsh KM, Bengtsson H, Hong C, Oberndorfer S, Roetzer T, Smirnov IV, Clarke JL, Aghi MK, Chang SM, Nelson SJ, Woehrer A, Phillips JJ, Solomon D, Costello JF. Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas. Neuro Oncol. 2018 Apr 09; 20(5):632-641. PMID: 29077933.
      View in: PubMed
    6. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon D. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810. PMID: 29476136.
      View in: PubMed
    7. Iorgulescu JB, Van Ziffle J, Stevers M, Grenert JP, Bastian BC, Chavez L, Stichel D, Buchhalter I, Samuel D, Nicolaides T, Banerjee A, Mueller S, Gupta N, Tihan T, Bollen AW, Northcott PA, Kool M, Pfister S, Korshunov A, Perry A, Solomon D. Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation. Acta Neuropathol. 2018 Apr; 135(4):635-638. PMID: 29435664.
      View in: PubMed
    8. Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon D. Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway. Acta Neuropathol. 2018 Mar; 135(3):485-488. PMID: 29428973.
      View in: PubMed
    9. Paret C, Russo A, Otto H, Mayer A, Zahnreich S, Wagner W, Samuel D, Scharnhorst D, Solomon D, Dhall G, Wong K, Bender H, Alt F, Wingerter A, Neu MA, Beck O, Prawitt D, Eder S, Henninger N, El Malki K, Lehmann N, Backes N, Roth L, Seidmann L, Sommer C, Brockmann MA, Staatz G, Schmidberger H, Faber J. Personalized therapy: CNS HGNET-BCOR responsiveness to arsenic trioxide combined with radiotherapy. Oncotarget. 2017 Dec 26; 8(69):114210-114225. PMID: 29371980.
      View in: PubMed
    10. Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian BC, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon D. Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Mod Pathol. 2018 Apr; 31(4):660-673. PMID: 29148537.
      View in: PubMed
    11. Wood MD, Tihan T, Perry A, Chacko G, Turner C, Pu C, Payne C, Yu A, Bannykh SI, Solomon D. Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities. Brain Pathol. 2018 03; 28(2):192-202. PMID: 28960623.
      View in: PubMed
    12. Lopez GY, Oberheim Bush NA, Phillips JJ, Bouffard JP, Moshel YA, Jaeckle K, Kleinschmidt-DeMasters BK, Rosenblum MK, Perry A, Solomon D. Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression. Acta Neuropathol. 2017 Dec; 134(6):961-963. PMID: 29063183.
      View in: PubMed
    13. Chan AK, Han SJ, Choy W, Beleford D, Aghi MK, Berger MS, Shieh JT, Bollen AW, Perry A, Phillips JJ, Butowski N, Solomon D. Familial melanoma-astrocytoma syndrome: synchronous diffuse astrocytoma and pleomorphic xanthoastrocytoma in a patient with germline CDKN2A/B deletion and a significant family history. Clin Neuropathol. 2017 Sep/Oct; 36(5):213-221. PMID: 28699883.
      View in: PubMed
    14. Graham RP, Yeh MM, Lam-Himlin D, Roberts LR, Terracciano L, Cruise MW, Greipp PT, Zreik RT, Jain D, Zaid N, Salaria SN, Jin L, Wang X, Rustin JG, Kerr SE, Sukov WR, Solomon D, Kakar S, Waterhouse E, Gill RM, Ferrell L, Alves VA, Nart D, Yilmaz F, Roessler S, Longerich T, Schirmacher P, Torbenson MS. Molecular testing for the clinical diagnosis of fibrolamellar carcinoma. Mod Pathol. 2018 Jan; 31(1):141-149. PMID: 28862261.
      View in: PubMed
    15. Kline CN, Packer RJ, Hwang EI, Raleigh DR, Braunstein S, Raffel C, Bandopadhayay P, Solomon D, Aboian M, Cha S, Mueller S. Case-based review: pediatric medulloblastoma. Neurooncol Pract. 2017 Sep; 4(3):138-150. PMID: 29692919.
      View in: PubMed
    16. Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert JP, Kline CN, Tihan T, Perry A, Gupta N, Solomon D. Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex. Acta Neuropathol. 2017 Oct; 134(4):671-673. PMID: 28776091.
      View in: PubMed
    17. Sorge C, Li R, Singh S, Reddy AT, Solomon D, Perry A, Friedman GK. Complete durable response of a pediatric anaplastic oligodendroglioma to temozolomide alone: Case report and review of literature. Pediatr Blood Cancer. 2017 Dec; 64(12). PMID: 28696020.
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    18. Ferris SP, Hofmann JW, Solomon D, Perry A. Characterization of gliomas: from morphology to molecules. Virchows Arch. 2017 Aug; 471(2):257-269. PMID: 28674742.
      View in: PubMed
    19. Dahlin LB, Scherman P, Besjakov J, Lindberg E, Solomon D, Horvai AE, Perry A. Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case. Clin Neuropathol. 2017 Jul/Aug; 36(4):164-170. PMID: 28438258.
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    20. Krings G, Joseph NM, Bean GR, Solomon D, Onodera C, Talevich E, Yeh I, Grenert JP, Hosfield E, Crawford ED, Jordan RC, van Zante A, Zaloudek C, Shin SJ, Chen YY. Genomic profiling of breast secretory carcinomas reveals distinct genetics from other breast cancers and similarity to mammary analog secretory carcinomas. Mod Pathol. 2017 Aug; 30(8):1086-1099. PMID: 28548128.
      View in: PubMed
    21. López G, Oberheim Bush NA, Berger MS, Perry A, Solomon D. Diffuse non-midline glioma with H3F3A K27M mutation: a prognostic and treatment dilemma. Acta Neuropathol Commun. 2017 05 15; 5(1):38. PMID: 28506301.
      View in: PubMed
    22. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon D. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 05 01; 19(5):699-709. PMID: 28453743.
      View in: PubMed
    23. Erwood AA, Velazquez-Vega JE, Neill S, Solomon D, Butowski N, Nowlan A, Dunbar E, Brat DJ. Chordoid glioma of the third ventricle: report of a rapidly progressive case. J Neurooncol. 2017 May; 132(3):487-495. PMID: 28315998.
      View in: PubMed
    24. Cuevas-Ocampo AK, Bollen AW, Goode B, Pajtler KW, Chavez L, Sharma T, Dai SC, McDermott M, Perry A, Korshunov A, Solomon D. Genetic confirmation that ependymoma can arise as part of multiple endocrine neoplasia type 1 (MEN1) syndrome. Acta Neuropathol. 2017 04; 133(4):661-663. PMID: 28238068.
      View in: PubMed
    25. Aboian MS, Solomon D, Felton E, Mabray MC, Villanueva-Meyer JE, Mueller S, Cha S. Imaging Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3 K27M Mutation. AJNR Am J Neuroradiol. 2017 Apr; 38(4):795-800. PMID: 28183840.
      View in: PubMed
    26. Lee J, Solomon D, Tihan T. The role of histone modifications and telomere alterations in the pathogenesis of diffuse gliomas in adults and children. J Neurooncol. 2017 03; 132(1):1-11. PMID: 28064387.
      View in: PubMed
    27. DeParis SW, Bloomer M, Han Y, Vagefi MR, Shieh JTC, Solomon D, Grenert J, de Alba Campomanes AG. Uveal Ganglioneuroma due to Germline PTEN Mutation (Cowden Syndrome) Presenting as Unilateral Infantile Glaucoma. Ocul Oncol Pathol. 2017 Jul; 3(2):122-128. PMID: 28868283.
      View in: PubMed
    28. Joseph NM, Chen YY, Nasr A, Yeh I, Talevich E, Onodera C, Bastian BC, Rabban JT, Garg K, Zaloudek C, Solomon D. Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. Mod Pathol. 2017 Feb; 30(2):246-254. PMID: 27813512.
      View in: PubMed
    29. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon D, Shieh JT. Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation. Acta Neuropathol. 2016 11; 132(5):757-760. PMID: 27624885.
      View in: PubMed
    30. Cohen JN, Solomon D, Horvai AE, Kakar S. Pancreatic involvement by mesenchymal chondrosarcoma harboring the HEY1-NCOA2 gene fusion. Hum Pathol. 2016 12; 58:35-40. PMID: 27544802.
      View in: PubMed
    31. Hale G, Liu X, Hu J, Xu Z, Che L, Solomon D, Tsokos C, Shafizadeh N, Chen X, Gill R, Kakar S. Correlation of exon 3 ß-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma. Mod Pathol. 2016 Nov; 29(11):1370-1380. PMID: 27469330.
      View in: PubMed
    32. Raleigh DR, Solomon D, Lloyd SA, Lazar A, Garcia MA, Sneed PK, Clarke JL, McDermott MW, Berger MS, Tihan T, Haas-Kogan DA. Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome. Neuro Oncol. 2017 01; 19(1):78-88. PMID: 27282397.
      View in: PubMed
    33. Ferris SP, Goode B, Joseph NM, Kline CN, Samuel D, Gupta N, Bollen A, Perry A, Mueller S, Solomon D. IDH1 mutation can be present in diffuse astrocytomas and giant cell glioblastomas of young children under 10 years of age. Acta Neuropathol. 2016 07; 132(1):153-5. PMID: 27161253; PMCID: PMC4915961 [Available on 07/01/17].
    34. Garcia MA, Solomon D, Haas-Kogan DA. Exploiting molecular biology for diagnosis and targeted management of pediatric low-grade gliomas. Future Oncol. 2016 Jun; 12(12):1493-506. PMID: 27072750; PMCID: PMC4915741 [Available on 06/01/17].
    35. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Yeh I, Bastian BC, Mueller S, Solomon D. Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas. Neuro Oncol. 2016 05; 18(5):752-3. PMID: 26902849; PMCID: PMC4827050 [Available on 05/01/17].
    36. Solomon D, Wood MD, Tihan T, Bollen AW, Gupta N, Phillips JJ, Perry A. Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. Brain Pathol. 2016 09; 26(5):569-80. PMID: 26517431.
      View in: PubMed
    37. Joseph NM, Solomon D, Frizzell N, Rabban JT, Zaloudek C, Garg K. Morphology and Immunohistochemistry for 2SC and FH Aid in Detection of Fumarate Hydratase Gene Aberrations in Uterine Leiomyomas From Young Patients. Am J Surg Pathol. 2015 Nov; 39(11):1529-39. PMID: 26457356.
      View in: PubMed
    38. Mabray MC, Glastonbury CM, Mamlouk MD, Punch GE, Solomon D, Cha S. Direct Cranial Nerve Involvement by Gliomas: Case Series and Review of the Literature. AJNR Am J Neuroradiol. 2015 Jul; 36(7):1349-54. PMID: 25857757.
      View in: PubMed
    39. Solomon D, Brohl AS, Khan J, Miettinen M. Clinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC-FOXO4 gene fusion. Am J Surg Pathol. 2014 Dec; 38(12):1724-5. PMID: 25321332.
      View in: PubMed
    40. Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec; 20(12):1394-6. PMID: 25401693; PMCID: PMC4257862.
    41. Raygor KP, Rowland NC, Cooke DL, Solomon D, Huang MC. Aneurysm of the posterior meningeal artery embedded within a dorsal exophytic medullary hemangioblastoma: surgical management and review of literature. J Cerebrovasc Endovasc Neurosurg. 2014 Sep; 16(3):293-8. PMID: 25340034; PMCID: PMC4205258.
    42. Walia V, Prickett TD, Kim JS, Gartner JJ, Lin JC, Zhou M, Rosenberg SA, Elble RC, Solomon D, Waldman T, Samuels Y. Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma. Hum Mutat. 2014 Nov; 35(11):1301-10. PMID: 25113440; PMCID: PMC4394620.
    43. Brohl AS, Solomon D, Chang W, Wang J, Song Y, Sindiri S, Patidar R, Hurd L, Chen L, Shern JF, Liao H, Wen X, Gerard J, Kim JS, Lopez Guerrero JA, Machado I, Wai DH, Picci P, Triche T, Horvai AE, Miettinen M, Wei JS, Catchpool D, Llombart-Bosch A, Waldman T, Khan J. The genomic landscape of the Ewing Sarcoma family of tumors reveals recurrent STAG2 mutation. PLoS Genet. 2014 Jul; 10(7):e1004475. PMID: 25010205; PMCID: PMC4091782.
    44. Solomon D, Kim JS, Waldman T. Cohesin gene mutations in tumorigenesis: from discovery to clinical significance. BMB Rep. 2014 Jun; 47(6):299-310. PMID: 24856830; PMCID: PMC4163871.
    45. Bailey ML, O'Neil NJ, van Pel DM, Solomon D, Waldman T, Hieter P. Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition. Mol Cancer Ther. 2014 Mar; 13(3):724-32. PMID: 24356817; PMCID: PMC4130349.
    46. Solomon D, Kim JS, Bondaruk J, Shariat SF, Wang ZF, Elkahloun AG, Ozawa T, Gerard J, Zhuang D, Zhang S, Navai N, Siefker-Radtke A, Phillips JJ, Robinson BD, Rubin MA, Volkmer B, Hautmann R, Küfer R, Hogendoorn PC, Netto G, Theodorescu D, James CD, Czerniak B, Miettinen M, Waldman T. Frequent truncating mutations of STAG2 in bladder cancer. Nat Genet. 2013 Dec; 45(12):1428-30. PMID: 24121789; PMCID: PMC3875130.
    47. Solomon D, Antonescu CR, Link TM, O'Donnell RJ, Folpe AL, Horvai AE. Hemosiderotic fibrolipomatous tumor, not an entirely benign entity. Am J Surg Pathol. 2013 Oct; 37(10):1627-30. PMID: 24025526.
      View in: PubMed
    48. Nicolaides TP, Li H, Solomon D, Hariono S, Hashizume R, Barkovich K, Baker SJ, Paugh BS, Jones C, Forshew T, Hindley GF, Hodgson JG, Kim JS, Rowitch DH, Weiss WA, Waldman TA, James CD. Targeted therapy for BRAFV600E malignant astrocytoma. Clin Cancer Res. 2011 Dec 15; 17(24):7595-604. PMID: 22038996; PMCID: PMC3638050.
    49. Solomon D, Kim T, Diaz-Martinez LA, Fair J, Elkahloun AG, Harris BT, Toretsky JA, Rosenberg SA, Shukla N, Ladanyi M, Samuels Y, James CD, Yu H, Kim JS, Waldman T. Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science. 2011 Aug 19; 333(6045):1039-43. PMID: 21852505.
      View in: PubMed
    50. Kim JS, Xu X, Li H, Solomon D, Lane WS, Jin T, Waldman T. Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells. Mol Cell Biol. 2011 Jul; 31(13):2756-71. PMID: 21536651; PMCID: PMC3133370.
    51. Duncan CG, Killela PJ, Payne CA, Lampson B, Chen WC, Liu J, Solomon D, Waldman T, Towers AJ, Gregory SG, McDonald KL, McLendon RE, Bigner DD, Yan H. Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes. Oncotarget. 2010 Aug; 1(4):265-77. PMID: 21113414.
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    52. Lopez GY, Reitman ZJ, Solomon D, Waldman T, Bigner DD, McLendon RE, Rosenberg SA, Samuels Y, Yan H. IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain. Biochem Biophys Res Commun. 2010 Jul 30; 398(3):585-7. PMID: 20603105; PMCID: PMC2987603.
    53. Michaud K, Solomon D, Oermann E, Kim JS, Zhong WZ, Prados MD, Ozawa T, James CD, Waldman T. Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res. 2010 Apr 15; 70(8):3228-38. PMID: 20354191; PMCID: PMC2855904.
    54. Solomon D, Kim JS, Ressom HW, Sibenaller Z, Ryken T, Jean W, Bigner D, Yan H, Waldman T. Sample type bias in the analysis of cancer genomes. Cancer Res. 2009 Jul 15; 69(14):5630-3. PMID: 19567670; PMCID: PMC3690469.
    55. Solomon D, Kim JS, Yang XR, Tucker MA, Goldstein AM, Samuels Y, Waldman T. Lack of inherited mutations of PTPRD in familial melanoma and melanoma-astrocytoma syndrome. Pigment Cell Melanoma Res. 2009 Aug; 22(4):489-91. PMID: 19500277.
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    56. Bourgo RJ, Siddiqui H, Fox S, Solomon D, Sansam CG, Yaniv M, Muchardt C, Metzger D, Chambon P, Roberts CW, Knudsen ES. SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity. Mol Biol Cell. 2009 Jul; 20(14):3192-9. PMID: 19458193; PMCID: PMC2710832.
    57. Stengel KR, Thangavel C, Solomon D, Angus SP, Zheng Y, Knudsen ES. Retinoblastoma/p107/p130 pocket proteins: protein dynamics and interactions with target gene promoters. J Biol Chem. 2009 Jul 17; 284(29):19265-71. PMID: 19279001; PMCID: PMC2740551.
    58. Solomon D, Kim JS, Cronin JC, Sibenaller Z, Ryken T, Rosenberg SA, Ressom H, Jean W, Bigner D, Yan H, Samuels Y, Waldman T. Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. Cancer Res. 2008 Dec 15; 68(24):10300-6. PMID: 19074898.
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    59. Solomon D, Kim JS, Jean W, Waldman T. Conspirators in a capital crime: co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in glioblastoma multiforme. Cancer Res. 2008 Nov 01; 68(21):8657-60. PMID: 18974105; PMCID: PMC2828676.
    60. Solomon D, Kim JS, Jenkins S, Ressom H, Huang M, Coppa N, Mabanta L, Bigner D, Yan H, Jean W, Waldman T. Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme. Cancer Res. 2008 Apr 15; 68(8):2564-9. PMID: 18381405; PMCID: PMC4394609.
    61. Kim HJ, DiBernardo AB, Sloane JA, Rasband MN, Solomon D, Kosaras B, Kwak SP, Vartanian TK. WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination. J Neurosci. 2006 May 24; 26(21):5849-59. PMID: 16723544.
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    62. Solomon D, Cardoso MC, Knudsen ES. Dynamic targeting of the replication machinery to sites of DNA damage. J Cell Biol. 2004 Aug 16; 166(4):455-63. PMID: 15314062; PMCID: PMC2172213.
    63. Angus SP, Mayhew CN, Solomon D, Braden WA, Markey MP, Okuno Y, Cardoso MC, Gilbert DM, Knudsen ES. RB reversibly inhibits DNA replication via two temporally distinct mechanisms. Mol Cell Biol. 2004 Jun; 24(12):5404-20. PMID: 15169903; PMCID: PMC419877.
    64. Gunawardena RW, Siddiqui H, Solomon D, Mayhew CN, Held J, Angus SP, Knudsen ES. Hierarchical requirement of SWI/SNF in retinoblastoma tumor suppressor-mediated repression of Plk1. J Biol Chem. 2004 Jul 09; 279(28):29278-85. PMID: 15105433.
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    65. Mayhew CN, Bosco EE, Solomon D, Knudsen ES, Angus SP. Analysis of RB action in DNA damage checkpoint response. Methods Mol Biol. 2004; 281:3-16. PMID: 15220518.
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    66. Siddiqui H, Solomon D, Gunawardena RW, Wang Y, Knudsen ES. Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition. Mol Cell Biol. 2003 Nov; 23(21):7719-31. PMID: 14560017; PMCID: PMC207566.
    67. Angus SP, Solomon D, Kuschel L, Hennigan RF, Knudsen ES. Retinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation. Mol Cell Biol. 2003 Nov; 23(22):8172-88. PMID: 14585976; PMCID: PMC262398.
    68. Solomon D, Wang Y, Fox SR, Lambeck TC, Giesting S, Lan Z, Senderowicz AM, Conti CJ, Knudsen ES. Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J Biol Chem. 2003 Aug 08; 278(32):30339-47. PMID: 12746453.
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    69. Park SK, Solomon D, Vartanian T. Growth factor control of CNS myelination. Dev Neurosci. 2001; 23(4-5):327-37. PMID: 11756748.
      View in: PubMed
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