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Suzaynn Schick, PhD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Address1001 Potrero Ave
San Francisco CA 94110
Phone628-206-5904
ORCID ORCID Icon0000-0001-7101-3077 Additional info
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    Collapse Biography 
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    University of California, San Francisco Postdoctoral StudiesGraduate Division
    University of California, San FranciscoPh.D.2001 Graduate Division (Biomedical Sciences)

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    I study the health effects of air pollution in human subjects. I focus on the chemistry and toxicity of smoke and on how smoking and using electronic cigarettes can cause heart and lung disease. My analysis of tobacco industry research showed that sidestream cigarette smoke (the primary constituent of secondhand cigarette smoke) is more toxic than the smoke that smokers inhale and that secondhand smoke becomes more toxic as it ages.

    I have published three controlled human exposure studies on the health effects of secondhand cigarette smoke which show that:
    1. A single 30-minute exposure to fresh sidestream cigarette smoke, at 350 micrograms of particles per cubic meter, decreases flow-mediated dilation of the brachial artery and increases plasma VEGF and endothelial progenitor cell motility. (These changes can increase the risk of heart attack.)
    2. For each increase in SHS exposure by 100 µg/m3 particles, the absolute maximal percent brachial artery flow-mediated dilation was reduced by 0.67%. (Even a little smoke can increase the risk of heart disease.)
    3. A single 30-minute exposure to aged cigarette smoke, at 1000 µg/m3 particles, increases nasal congestion in healthy human subjects. (Nasal congestion can lead to sinus infections.)

    My research on the chemistry and toxicity of cigarette smoke has helped define a new health risk from smoking: thirdhand cigarette smoke. Thirdhand smoke is the tiny droplets of oils and waxes (tar) that stick to surfaces, like walls, furniture, clothing and hair. Thirdhand smoke cannot be removed by ventilation. Many of the toxins and carcinogens in smoke linger for days, months and years after the cigarettes are gone. My laboratory is funded by the California Tobacco-Related Disease Research Program to study how humans absorb thirdhand smoke from the environment. My laboratory is also funded by the FDA and the NIH to study the cardiovascular effects of tobacco and nicotine delivery products. I am member of the California Thirdhand Smoke Consortium, the UCSF Helen Diller Family Comprehensive Cancer Center and the UCSF Center for Tobacco Control Research and Education. My goals are to understand how smoke causes heart attacks and respiratory disease and to educate society on the true impact that air pollution has on human health.

    Collapse Research 
    Collapse Research Activities and Funding
    Acute Cardiopulmonary Effects of Controlled Exposure to Wood Smoke
    NIH/NIEHS R21ES024878Aug 1, 2015 - Jul 31, 2017
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Thirdhand smoke exposure causes replication stress and impaired transcription in human lung cells. Environ Mol Mutagen. 2020 Jul; 61(6):635-646. Sarker AH, Trego KS, Zhang W, Jacob P, Snijders AM, Mao JH, Schick SF, Cooper PK, Hang B. PMID: 32267018.
      View in: PubMed   Mentions:    Fields:    
    2. Thirdhand Smoke at Philip Morris. Nicotine Tob Res. 2019 11 19; 21(12):1680-1688. Whitlatch A, Schick S. PMID: 30053240.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    3. Assessing Toxicity and in Vitro Bioactivity of Smoked Cigarette Leachate Using Cell-Based Assays and Chemical Analysis. Chem Res Toxicol. 2019 08 19; 32(8):1670-1679. Xu EG, Richardot WH, Li S, Buruaem L, Wei HH, Dodder NG, Schick SF, Novotny T, Schlenk D, Gersberg RM, Hoh E. PMID: 31286770.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Proceedings of the 15th Conference of the International Society of Indoor Air Quality & Climate, Philadelphia, PA, USA July 22 to 27, 2018. Measuring Aerosol Particle Emissions from Cannabis Vaporization and Dabbing. 2019. Jaques, PA, Zalay, M, Huang, A, Jee, K, Schick, SF.
    5. Experimental Acute Exposure to Thirdhand Smoke and Changes in the Human Nasal Epithelial Transcriptome: A Randomized Clinical Trial. JAMA Netw Open. 2019 06 05; 2(6):e196362. Pozuelos GL, Kagda MS, Schick S, Girke T, Volz DC, Talbot P. PMID: 31251375.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    6. Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells. J Am Coll Cardiol. 2019 06 04; 73(21):2722-2737. Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC. PMID: 31146818.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    7. Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation. Am J Physiol Heart Circ Physiol. 2019 04 01; 316(4):H801-H827. Conklin DJ, Schick S, Blaha MJ, Carll A, DeFilippis A, Ganz P, Hall ME, Hamburg N, O'Toole T, Reynolds L, Srivastava S, Bhatnagar A. PMID: 30707616.
      View in: PubMed   Mentions:
    8. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 07 01; 315(1):L25-L40. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. PMID: 29543040.
      View in: PubMed   Mentions:
    9. Short-term early exposure to thirdhand cigarette smoke increases lung cancer incidence in mice. Clin Sci (Lond). 2018 02 28; 132(4):475-488. Hang B, Wang Y, Huang Y, Wang P, Langley SA, Bi L, Sarker AH, Schick SF, Havel C, Jacob P, Benowitz N, Destaillats H, Tang X, Xia Y, Jen KY, Gundel LA, Mao JH, Snijders AM. PMID: 29440622.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsPHPublic Health
    10. Biomarkers of exposure to new and emerging tobacco delivery products. . 2017 Sep 01; 313(3):L425-L452. Schick SF, Blount BC, Jacob P, Saliba NA, Bernert JT, El Hellani A, Jatlow P, Pappas RS, Wang L, Foulds J, Ghosh A, Hecht SS, Gomez JC, Martin JR, Mesaros C, Srivastava S, St Helen G, Tarran R, Lorkiewicz PK, Blair IA, Kimmel HL, Doerschuk CM, Benowitz NL, Bhatnagar A. PMID: 28522563.
      View in: PubMed   Mentions:
    11. Early exposure to thirdhand cigarette smoke affects body mass and the development of immunity in mice. Sci Rep. 2017 02 03; 7:41915. Hang B, Snijders AM, Huang Y, Schick SF, Wang P, Xia Y, Havel C, Jacob P, Benowitz N, Destaillats H, Gundel LA, Mao JH. PMID: 28157226.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsPHPublic Health
    12. Thirdhand Smoke: New Evidence, Challenges, and Future Directions. Chem Res Toxicol. 2017 01 17; 30(1):270-294. Jacob P, Benowitz NL, Destaillats H, Gundel L, Hang B, Martins-Green M, Matt GE, Quintana PJ, Samet JM, Schick SF, Talbot P, Aquilina NJ, Hovell MF, Mao JH, Whitehead TP. PMID: 28001376.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsPHPublic Health
    13. One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function. J Am Heart Assoc. 2016 07 27; 5(8). Wang X, Derakhshandeh R, Liu J, Narayan S, Nabavizadeh P, Le S, Danforth OM, Pinnamaneni K, Rodriguez HJ, Luu E, Sievers RE, Schick SF, Glantz SA, Springer ML. PMID: 27464788.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsPHPublic Health
    14. From the Cover: Thirdhand Cigarette Smoke Causes Stress-Induced Mitochondrial Hyperfusion and Alters the Transcriptional Profile of Stem Cells. Toxicol Sci. 2016 09; 153(1):55-69. Bahl V, Johnson K, Phandthong R, Zahedi A, Schick SF, Talbot P. PMID: 27255386.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Corrigendum: Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke. Sci Rep. 2016 Apr 13; 6:23849. Xu B, Chen M, Yao M, Ji X, Mao Z, Tang W, Qiao S, Schick SF, Mao JH, Hang B, Xia Y. PMID: 27072199.
      View in: PubMed   Mentions:    Fields:    
    16. Impairment of Endothelial Function by Little Cigar Secondhand Smoke. Tob Regul Sci. 2016 Jan 01; 2(1):56-63. Liu J, Wang X, Narayan S, Glantz SA, Schick SF, Springer ML. PMID: 26753171.
      View in: PubMed   Mentions:
    17. Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation. Toxicol Sci. 2016 Mar; 150(1):234-46. Bahl V, Weng NJ, Schick SF, Sleiman M, Whitehead J, Ibarra A, Talbot P. PMID: 26719373.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    18. Thirdhand smoke: Chemical dynamics, cytotoxicity, and genotoxicity in outdoor and indoor environments. Toxicol In Vitro. 2016 Apr; 32:220-31. Bahl V, Shim HJ, Jacob P, Dias K, Schick SF, Talbot P. PMID: 26689327.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    19. Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke. Sci Rep. 2015 Oct 22; 5:15512. Xu B, Chen M, Yao M, Ji X, Mao Z, Tang W, Qiao S, Schick SF, Mao JH, Hang B, Xia Y. PMID: 26489853.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    20. Correction: A novel minimally-invasive method to sample human endothelial cells for molecular profiling. PLoS One. 2015; 10(5):e0126062. Waldo SW, Brenner DA, McCabe JM, De la Cruz M, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY. PMID: 25938419.
      View in: PubMed   Mentions:    Fields:    
    21. A novel minimally-invasive method to sample human endothelial cells for molecular profiling. PLoS One. 2015; 10(2):e0118081. Waldo SW, Brenner DA, McCabe JM, Dela Cruz M, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY. PMID: 25679506.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    22. Thirdhand cigarette smoke: factors affecting exposure and remediation. PLoS One. 2014; 9(10):e108258. Bahl V, Jacob P, Havel C, Schick SF, Talbot P. PMID: 25286392.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCellsPHPublic Health
    23. Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function. Nicotine Tob Res. 2014 May; 16(5):584-90. Pinnamaneni K, Sievers RE, Sharma R, Selchau AM, Gutierrez G, Nordsieck EJ, Su R, An S, Chen Q, Wang X, Derakhshandeh R, Aschbacher K, Heiss C, Glantz SA, Schick SF, Springer ML. PMID: 24302638.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsPHPublic Health
    24. Nicotelline: a proposed biomarker and environmental tracer for particulate matter derived from tobacco smoke. Chem Res Toxicol. 2013 Nov 18; 26(11):1615-31. Jacob P, Goniewicz ML, Havel CM, Schick SF, Benowitz NL. PMID: 24125094.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsPHPublic Health
    25. Thirdhand cigarette smoke in an experimental chamber: evidence of surface deposition of nicotine, nitrosamines and polycyclic aromatic hydrocarbons and de novo formation of NNK. Tob Control. 2014 Mar; 23(2):152-9. Schick SF, Farraro KF, Perrino C, Sleiman M, van de Vossenberg G, Trinh MP, Hammond SK, Jenkins BM, Balmes J. PMID: 23716171.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsPHPublic Health
    26. Thirdhand smoke causes DNA damage in human cells. Mutagenesis. 2013 Jul; 28(4):381-91. Hang B, Sarker AH, Havel C, Saha S, Hazra TK, Schick S, Jacob P, Rehan VK, Chenna A, Sharan D, Sleiman M, Destaillats H, Gundel LA. PMID: 23462851.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCellsPHPublic Health
    27. Thirty minute-exposure to aged cigarette smoke increases nasal congestion in nonsmokers. J Toxicol Environ Health A. 2013; 76(10):601-13. Schick SF, van den Vossenberg G, Luo A, Whitlatch A, Jacob P, Balmes J, Shusterman D. PMID: 23859154.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    28. Aerosol Science and Technology. An Apparatus for Generating Aged Cigarette Smoke for Controlled Human Exposure Studies. 2012; (46):1246-1255. Suzaynn F. Schick, Kathryn F. Farraro, Jiaxi Fang, Sarah Nasir, Justin Kim, Donald Lucas, Hofer Wong, John Balmes, D. Ken Giles, and Bryan Jenkins.View Publication.
    29. The exposure-dependent effects of aged secondhand smoke on endothelial function. J Am Coll Cardiol. 2012 May 22; 59(21):1908-13. Frey PF, Ganz P, Hsue PY, Benowitz NL, Glantz SA, Balmes JR, Schick SF. PMID: 22595411.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    30. Pilot evaluation of the nasal nitric oxide response to humming as an index of osteomeatal patency. Am J Rhinol Allergy. 2012 Mar-Apr; 26(2):123-6. Shusterman DJ, Weaver EM, Goldberg AN, Schick SF, Wong HH, Balmes JR. PMID: 22487289.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    31. Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary research agenda. Environ Health Perspect. 2011 Sep; 119(9):1218-26. Matt GE, Quintana PJ, Destaillats H, Gundel LA, Sleiman M, Singer BC, Jacob P, Benowitz N, Winickoff JP, Rehan V, Talbot P, Schick S, Samet J, Wang Y, Hang B, Martins-Green M, Pankow JF, Hovell MF. PMID: 21628107.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsPHPublic Health
    32. Thirdhand smoke: here to stay. Tob Control. 2011 Jan; 20(1):1-3. Schick SF, Schick S. PMID: 21172855.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansPHPublic Health
    33. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol. 2008 May 06; 51(18):1760-71. Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y. PMID: 18452782.
      View in: PubMed   Mentions: 80     Fields:    Translation:HumansCellsPHPublic Health
    34. Pilot study of compliance with healthcare facility smoking laws in Georgia. Georgian Med News. 2008 Jan; (154):47-52. Schick S, Gvinianidze K, Tsereteli D, Novotny T, Hammond K. PMID: 18323594.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    35. The tobacco industry and the Data Quality Act. Science. 2007 Aug 17; 317(5840):898. Schick SF, Bero LA, Cook DM. PMID: 17702925.
      View in: PubMed   Mentions: 1     Fields:    
    36. Concentrations of the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in sidestream cigarette smoke increase after release into indoor air: results from unpublished tobacco industry research. Cancer Epidemiol Biomarkers Prev. 2007 Aug; 16(8):1547-53. Schick SF, Glantz S. PMID: 17684127.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCellsPHPublic Health
    37. Old ways, new means: tobacco industry funding of academic and private sector scientists since the Master Settlement Agreement. Tob Control. 2007 Jun; 16(3):157-64. Schick SF, Glantz SA. PMID: 17565125.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansPHPublic Health
    38. Sidestream cigarette smoke toxicity increases with aging and exposure duration. Tob Control. 2006 Dec; 15(6):424-9. Schick SF, Schick S, Glantz SA. PMID: 17130369.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsPHPublic Health
    39. Philip Morris toxicological experiments with fresh sidestream smoke: more toxic than mainstream smoke. Tob Control. 2005 Dec; 14(6):396-404. Schick S, Glantz S. PMID: 16319363.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsPHPublic Health
    40. Scientific analysis of second-hand smoke by the tobacco industry, 1929-1972. Nicotine Tob Res. 2005 Aug; 7(4):591-612. Schick S, Glantz S. PMID: 16085530.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    41. Implications of ASHRAE's guidelines for ventilation in smoking permitted areas. ASHRAE Journal. 2004; 3(46):54-61. Glantz, Stanton A Schick, Suzaynn F.
    42. Adhesive interactions in peri-implantation morphogenesis and placentation. Reprod Toxicol. 1997 Mar-Jun; 11(2-3):367-75. Damsky Ch, Schick SF, Klimanskaya I, Stephens L, Zhou Y, Fisher S. PMID: 9100312.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
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