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Matthew Springer, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB
San Francisco CA 94117
Phone415-502-8404
ORCID ORCID Icon0000-0002-6689-8234 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UC Berkeley, Berkeley, CABA5/1985Molecular Biology
    Stanford, Stanford, CAPhD1/1992Biological Sciences
    Stanford, Stanford, CAPostdoctoral7/1993Cell Biology/Biochemistry
    Stanford, Stanford, CAPostdoctoral11/1997Molecular Pharmacology

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    RESEARCH INTERESTS:

    Dr. Matthew L. Springer received his BA from the University of California, Berkeley in 1985 and his PhD from Stanford University in 1992. He did postdoctoral research at Stanford and continued his research there as a senior scientist until joining the UCSF faculty in 2003, where he is currently one of two non-clinicians on the faculty of the Division of Cardiology. The close juxtaposition of his basic research background with the clinical cardiologists in the Division has resulted in an active translational research program.

    Dr. Springer's research interests include cell therapy and gene therapy approaches to studying cardiovascular disease, with the goals of exploring potential treatments and understanding underlying mechanisms involved in angiogenesis, vascular function, and treatments for myocardial infarction. The laboratory is studying the therapeutic effects of ultrasound-guided bone marrow cell implantation into the heart after myocardial infarction, with a special emphasis on the therapeutic implications of the age and cardiac disease state of the cell donor. Similarly, the lab is studying the effects of age and disease on circulating angiogenic cells (sometimes called endothelial progenitor cells), with a focus on the roles of endothelial nitric oxide synthase and nitric oxide in the function of these cells. The main angiogenesis interest is how cardiac motion and cyclical forces influences angiogenic gene expression and cell behavior. Currently, a large effort involves the study of vascular reactivity using a rat model of endothelium-dependent flow-mediated vasodilation that they developed, and how vascular endothelial function is affected by exposure to secondhand smoke from tobacco and marijuana.

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    Collapse Research Activities and Funding
    Validation of NIDA research marijuana as a model for cardiovascular research
    NIH/NIDA R21DA050995Apr 15, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Inhibition of Galectin-3 for Therapy of Remodeling After Myocardial Infarction
    NIH/NIA R44AG054386Aug 15, 2016 - Mar 31, 2019
    Role: Co-Principal Investigator
    Measuring relative cardiovascular health risks of inhaled tobacco products
    NIH/NHLBI R01HL120062Jun 1, 2014 - May 31, 2019
    Role: Principal Investigator
    Protein inhibitor of galectin-3 to limit fibrosis after myocardial infarction
    NIH/NHLBI R43HL120645Sep 4, 2013 - Aug 31, 2014
    Role: Co-Principal Investigator
    Evaluation of harmful effects of cannabis smoke on vascular endothelial function
    NIH/NIDA R21DA031966Sep 15, 2011 - Jun 30, 2014
    Role: Principal Investigator
    Bone marrow cell therapy for cardiac disease: Impact of donor age and infarction
    NIH/NHLBI R21HL097129Jul 1, 2010 - Jun 30, 2012
    Role: Principal Investigator
    The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function
    NIH/NHLBI R01HL086917Aug 1, 2007 - Jun 30, 2013
    Role: Principal Investigator
    Closed-Chest Cell Injections into Mouse Myocardium Targeted by Ultrasound
    NIH/NIBIB R03EB005802Sep 15, 2005 - Aug 31, 2007
    Role: Principal Investigator
    CELL MEDIATED GENE THERAPY FOR ATHEROSCLEROSIS
    NIH/NHLBI F32HL008991Mar 26, 1994
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. JUUL and Combusted Cigarettes Comparably Impair Endothelial Function. Tob Regul Sci. 2020 Jan; 6(1):30-37. Rao P, Liu J, Springer ML. PMID: 31930162.
      View in: PubMed   Mentions:
    2. Abstract 224: Sub-cytotoxic Levels of Heavy Metals Induce Pro-inflammatory Signaling in the Aortic Endothelium without Impairing Flow-Mediated Dilation in Rats. Circulation Research. 2019 Aug 2; 125(Suppl_1). Pooneh Nabavizadeh, Sharina Ibrahim, Adam Fries, Jiangtao Liu, Ronak Derakhshandeh, Matthew L Springer. .
      View in: Publisher Site   Mentions:
    3. Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells. J Am Coll Cardiol. 2019 06 04; 73(21):2722-2737. Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC. PMID: 31146818.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smoke. Tob Control. 2018 11; 27(Suppl 1):s13-s19. Nabavizadeh P, Liu J, Havel CM, Ibrahim S, Derakhshandeh R, Jacob Iii P, Springer ML. PMID: 30206183.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    5. Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes. Mol Ther. 2018 07 05; 26(7):1685-1693. An S, Wang X, Ruck MA, Rodriguez HJ, Kostyushev DS, Varga M, Luu E, Derakhshandeh R, Suchkov SV, Kogan SC, Hermiston ML, Springer ML. PMID: 29914756.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 07 01; 315(1):L25-L40. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. PMID: 29543040.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCellsPHPublic Health
    7. Marijuana, Secondhand Smoke, and Social Acceptability. JAMA Intern Med. 2018 01 01; 178(1):13-14. Glantz SA, Halpern-Felsher B, Springer ML. PMID: 29159409.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsPHPublic Health
    8. One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function. J Am Heart Assoc. 2016 07 27; 5(8). Wang X, Derakhshandeh R, Liu J, Narayan S, Nabavizadeh P, Le S, Danforth OM, Pinnamaneni K, Rodriguez HJ, Luu E, Sievers RE, Schick SF, Glantz SA, Springer ML. PMID: 27464788.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsPHPublic Health
    9. San Francisco Medicine. CANNABIS: Clearing some smoke?. 2016; 2(89):26. View Publication.
    10. Circulating angiogenic cell function is inhibited by cortisol in vitro and associated with psychological stress and cortisol in vivo. Psychoneuroendocrinology. 2016 May; 67:216-23. Aschbacher K, Derakhshandeh R, Flores AJ, Narayan S, Mendes WB, Springer ML. PMID: 26925833.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction. J Am Heart Assoc. 2016 Jan 06; 5(1). Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML. PMID: 26738788.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    12. Impairment of Endothelial Function by Little Cigar Secondhand Smoke. Tob Regul Sci. 2016 Jan 01; 2(1):56-63. Liu J, Wang X, Narayan S, Glantz SA, Schick SF, Springer ML. PMID: 26753171.
      View in: PubMed   Mentions:
    13. Protein engineering to develop a redox insensitive endothelial nitric oxide synthase. Redox Biol. 2014; 2C:156-164. View Publication.
    14. Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function. Nicotine Tob Res. 2014 May; 16(5):584-90. Pinnamaneni K, Sievers RE, Sharma R, Selchau AM, Gutierrez G, Nordsieck EJ, Su R, An S, Chen Q, Wang X, Derakhshandeh R, Aschbacher K, Heiss C, Glantz SA, Schick SF, Springer ML. PMID: 24302638.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsPHPublic Health
    15. Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients. Br J Nutr. 2014 Apr 14; 111(7):1245-52. Horn P, Amabile N, Angeli FS, Sansone R, Stegemann B, Kelm M, Springer ML, Yeghiazarians Y, Schroeter H, Heiss C. PMID: 24286443.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    16. Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants. PLoS One. 2013; 8(4):e61413. Fang Q, Mok PY, Thomas AE, Haddad DJ, Saini SA, Clifford BT, Kapasi NK, Danforth OM, Usui M, Ye W, Luu E, Sharma R, Bartel MJ, Pathmanabhan JA, Ang AA, Sievers RE, Lee RJ, Springer ML. PMID: 23630585.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo. J Appl Physiol (1985). 2013 Mar 15; 114(6):752-60. Chen Q, Sievers RE, Varga M, Kharait S, Haddad DJ, Patton AK, Delany CS, Mutka SC, Blonder JP, Dubé GP, Rosenthal GJ, Springer ML. PMID: 23349456.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    18. Gene therapy and angiogenesis. Cardiology: An Illustrated Textbook. K. Chatterjee et al., eds. 2013; 2013-2029. Springer ML..
    19. Earthquake safety at work: An important topic to review with patients. San Francisco Medicine. 2012; 85(9):12-13. View Publication.
    20. Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair. Sci Transl Med. 2012 Aug 08; 4(146):146ra109. Lin YD, Luo CY, Hu YN, Yeh ML, Hsueh YC, Chang MY, Tsai DC, Wang JN, Tang MJ, Wei EI, Springer ML, Hsieh PC. PMID: 22875829.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    21. Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. J Tissue Sci Eng. 2011 Nov 18; S3. Wang X, Takagawa J, Haddad DJ, Pinnamaneni K, Zhang Y, Sievers RE, Grossman W, Yeghiazarians Y, Springer ML. PMID: 22675670.
      View in: PubMed   Mentions:
    22. Blunting half of the double-edged sword: potential use of interleukin-10 to protect bone marrow-derived cells after myocardial infarction. Circ Res. 2011 Nov 11; 109(11):1196-8. Springer ML, Wang X. PMID: 22076503.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    23. Higher fasting glucose levels are associated with reduced circulating angiogenic cell migratory capacity among healthy individuals. Am J Cardiovasc Dis. 2012; 2(1):12-9. Aschbacher K, Chen Q, Varga M, Haddad DJ, Yeghiazarians Y, Epel E, Wolkowitz OM, Springer ML. PMID: 22254209.
      View in: PubMed   Mentions:
    24. Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med. 2011 Sep 14; 3(100):100ra90. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML. PMID: 21918107.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    25. Nitric oxide counters the inhibitory effects of uremic toxin indoxyl sulfate on endothelial cells by governing ERK MAP kinase and myosin light chain activation. Biochem Biophys Res Commun. 2011 Jun 17; 409(4):758-63. Kharait S, Haddad DJ, Springer ML. PMID: 21621512.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    26. Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Cardiovasc Pathol. 2011; 20:204-212. Zhang Y, Sievers RE, Prasad M, Mirsky R, Shih H, Wong ML, Angeli FS, Ye J, Takagawa J, Koskenvuo JW, Springer ML, Grossman W, Boyle AJ, Yeghiazarians Y.
    27. The launch of American Journal of Cardiovascular Disease. Am J Cardiovasc Dis. 2011; 1:i-ii. Roberts WC, Springer ML, Wang X, Wang D.
    28. Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2212-8. Heiss C, Schanz A, Amabile N, Jahn S, Chen Q, Wong ML, Rassaf T, Heinen Y, Cortese-Krott M, Grossman W, Yeghiazarians Y, Springer ML. PMID: 20705916.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    29. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 2010 Jul 13; 56(3):218-24. Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y. PMID: 20620742.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    30. Assessment of myocardial angiogenesis and vascularity in small animal models. Methods Mol Biol. 2010; 660:149-67. Springer ML. PMID: 20680818.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    31. Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther. 2009 Jul; 17(7):1250-6. Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. PMID: 19384293.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    32. Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Biol. 2008 Sep; 28(9):1614-20. Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau HM, Alitalo K, Eriksson U, Carmeliet P, Moons L. PMID: 18511699.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    33. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol. 2008 May 06; 51(18):1760-71. Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y. PMID: 18452782.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCellsPHPublic Health
    34. Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells. J Cell Physiol. 2008 May; 215(2):366-73. Heiss C, Wong ML, Block VI, Lao D, Real WM, Yeghiazarians Y, Lee RJ, Springer ML. PMID: 17960557.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    35. Living both music and medicine: Where the two practices intersect. (One of several sections.). San Francisco Medicine. 2008; 81(2):38-39. View Publication.
    36. In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H1086-93. Heiss C, Sievers RE, Amabile N, Momma TY, Chen Q, Natarajan S, Yeghiazarians Y, Springer ML. PMID: 18055528.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    37. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. J Appl Physiol (1985). 2007 Jun; 102(6):2104-11. Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. PMID: 17347379.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimals
    38. Localization of vascular response to VEGF is not dependent on heparin binding. FASEB J. 2007 Jul; 21(9):2074-85. Springer ML, Banfi A, Ye J, von Degenfeld G, Kraft PE, Saini SA, Kapasi NK, Blau HM. PMID: 17325231.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    39. 356: Reduced number and function of circulating endothelial progenitor cells in patients with pulmonary arterial hypertension. The Journal of Heart and Lung Transplantation. 2007 Feb 1; 26(2):s187-s188. R.K. Rao, J. Ye, W.M. Real, M. Springer, W. Grossman, T. de Marco, Y. Yeghiazarians. .
      View in: Publisher Site   Mentions:
    40. 355: Increased circulating endothelial microparticles predict hemodynamic severity of untreated pulmonary hypertension. The Journal of Heart and Lung Transplantation. 2007 Feb 1; 26(2):s187. N. Amabile, C. Heiss, W.M. Real, P. Minasi, M.L. Springer, D. McGoughlin, E.J. Rame, W. Grossman, T. de Marco, Y. Yeghiazarians. .
      View in: Publisher Site   Mentions:
    41. Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H1187-92. Zhang Y, Takagawa J, Sievers RE, Khan MF, Viswanathan MN, Springer ML, Foster E, Yeghiazarians Y. PMID: 17028161.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    42. A balancing act: therapeutic approaches for the modulation of angiogenesis. Curr Opin Investig Drugs. 2006 Mar; 7(3):243-50. Springer ML. PMID: 16555684.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    43. Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia. FASEBJ. 2006; 20(14):2657-9. von Degenfeld G, Banfi A, Springer ML, Wagner RA, Jacobi J, Ozawa CR, Merchant MJ, Cooke JP, Blau HM.
    44. 239. Histological Measurement of Myocardial Infarct Area Does Not Provide a Sensitive Assessment of Infarct Size in a Mouse Chronic Infarct Model. Molecular Therapy. 2006 Jan 1; 13:s92. Junya Takagawa, Yan Zhang, Richard E. Sievers, Neel K. Kapasi, Maelene L. Wong, Yerem Yeghiazarians, Randall J. Lee, William Grossman, Matthew L. Springer. .
      View in: Publisher Site   Mentions:
    45. 453. Injectionof Different Adult Cell Types into Mouse Myocardium Three Days after Myocardial Infarction Using a Novel Echo-Guided Technique Improves Cardiac Function. Molecular Therapy. 2006 Jan 1; 13:s175. Yan Zhang, Junya Takagawa, Richard E. Sievers, Maelene L. Wong, Christian Heiss, Mohan N. Viswanathan, Neel K. Kapasi, Jianqin Ye, Elyse Foster, William Grossman, Matthew L. Springer, Yerem Yeghiazarians. .
      View in: Publisher Site   Mentions:
    46. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H560-76. Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald DM. PMID: 16172168.
      View in: PubMed   Mentions: 251     Fields:    Translation:AnimalsCells
    47. Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1307-14. Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y. PMID: 15908468.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    48. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest. 2004 Feb; 113(4):516-27. Ozawa CR, Banfi A, Glazer NL, Thurston G, Springer ML, Kraft PE, McDonald DM, Blau HM. PMID: 14966561.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    49. Myoblast-mediated gene transfer for therapeutic angiogenesis and arteriogenesis. Br J Pharmacol. 2003 Oct; 140(4):620-6. von Degenfeld G, Banfi A, Springer ML, Blau HM. PMID: 14534145.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    50. Localized arteriole formation directly adjacent to the site of VEGF-induced angiogenesis in muscle. Mol Ther. 2003 Apr; 7(4):441-9. Springer ML, Ozawa CR, Banfi A, Kraft PE, Ip TK, Brazelton TR, Blau HM. PMID: 12727106.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    51. RIP2, a checkpoint in myogenic differentiation. Mol Cell Biol. 2002 Aug; 22(16):5879-86. Munz B, Hildt E, Springer ML, Blau HM. PMID: 12138198.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    52. Transient production of alpha-smooth muscle actin by skeletal myoblasts during differentiation in culture and following intramuscular implantation. Cell Motil Cytoskeleton. 2002 Apr; 51(4):177-86. Springer ML, Ozawa CR, Blau HM. PMID: 11977092.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    53. VEGF therapy in heart disease: for better or for worse? Drug Discov Today. 2002 Feb 15; 7(4):209-11. Springer ML. PMID: 11839510.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    54. Gene delivery to muscle. Curr Protoc Hum Genet. 2002 Feb; Chapter 13:Unit13.4. Springer ML, Rando TA, Blau HM. PMID: 18428326.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    55. Myoblast-mediated gene transfer for therapeutic angiogenesis. Methods Enzymol. 2002; 346:145-57. Banfi A, Springer ML, Blau HM. PMID: 11883066.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    56. Not the usual suspects: the unexpected sources of tissue regeneration. J Clin Invest. 2001 Jun; 107(11):1355-6. Springer ML, Brazelton TR, Blau HM. PMID: 11390416.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    57. VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation. 2000 Aug 22; 102(8):898-901. Lee RJ, Springer ML, Blanco-Bose WE, Shaw R, Ursell PC, Blau HM. PMID: 10952959.
      View in: PubMed   Mentions: 161     Fields:    Translation:Animals
    58. Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor. J Gene Med. 2000 Jul-Aug; 2(4):279-88. Springer ML, Hortelano G, Bouley DM, Wong J, Kraft PE, Blau HM. PMID: 10953919.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    59. Angiogenesis monitored by perfusion with a space-filling microbead suspension. Mol Ther. 2000 Jan; 1(1):82-7. Springer ML, Ip TK, Blau HM. PMID: 10933915.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    60. A novel means of drug delivery: myoblast-mediated gene therapy and regulatable retroviral vectors. Annu Rev Pharmacol Toxicol. 2000; 40:295-317. Ozawa CR, Springer ML, Blau HM. PMID: 10836138.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    61. Ex vivo gene therapy using myoblasts and regulatable retroviral vectors. In Gene Therapy: Therapeutic Mechanisms and Strategies, NS Templeton and DD Lasic, eds. 2000; 61-80. Ozawa CR, Springer ML, Blau HM.
    62. Analysis of immune responses to varicella zoster viral proteins induced by DNA vaccination. Antiviral Res. 1999 Dec 31; 44(3):179-92. Abendroth A, Slobedman B, Springer ML, Blau HM, Arvin AM. PMID: 10651069.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    63. VEGF gene delivery to muscle: potential role for vasculogenesis in adults. Mol Cell. 1998 Nov; 2(5):549-58. Springer ML, Chen AS, Kraft PE, Bednarski M, Blau HM. PMID: 9844628.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    64. Inhibition of solid tumor growth by Fas ligand-expressing myoblasts. Somat Cell Mol Genet. 1998 Sep; 24(5):281-9. Springer ML, Kraft PE, Blau HM. PMID: 10696236.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    65. Immune response and myoblasts that express Fas ligand. Science. 1997 Nov 14; 278(5341):1322-4. Kang SM, Hoffmann A, Le D, Springer ML, Stock PG, Blau HM. PMID: 9411754.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    66. High-efficiency retroviral infection of primary myoblasts. Somat Cell Mol Genet. 1997 May; 23(3):203-9. Springer ML, Blau HM. PMID: 9330631.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    67. Towards a treatment for Tay-Sachs disease. Molec. Med. Today. 1996; 2:232. Springer, ML.
    68. Muscle-mediated gene therapy. N Engl J Med. 1995 Dec 07; 333(23):1554-6. Blau HM, Springer ML. PMID: 7477172.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    69. Gene therapy--a novel form of drug delivery. N Engl J Med. 1995 Nov 02; 333(18):1204-7. Blau HM, Springer ML. PMID: 7565977.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    70. Gene therapy for restenosis: retinoblastoma to the rescue. Molec. Med. Today. 1995; 1:57. Springer, ML.
    71. Cell implantation treatment for MPS VII. Molec. Med. Today. 1995; 1:111. Springer, ML.
    72. Stage-specific requirement for myosin II during Dictyostelium development. Development. 1994 Sep; 120(9):2651-60. Springer ML, Patterson B, Spudich JA. PMID: 7956839.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    73. Genetic control of fungal differentiation: the three sporulation pathways of Neurospora crassa. Bioessays. 1993 Jun; 15(6):365-74. Springer ML. PMID: 8357339.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    74. Timing of synthesis and cellular localization of two conidiation-specific proteins of Neurospora crassa. Dev Biol. 1992 Aug; 152(2):255-62. Springer ML, Hager KM, Garrett-Engele C, Yanofsky C. PMID: 1386581.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    75. Expression of con genes along the three sporulation pathways of Neurospora crassa. Genes Dev. 1992 Jun; 6(6):1052-7. Springer ML, Yanofsky C. PMID: 1534304.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    76. Tergitol-induced colonial growth without inhibition of conidiation. Fungal Genet. Newsl. 1991; 38:92. Springer, ML.
    77. A morphological and genetic analysis of conidiophore development in Neurospora crassa. Genes Dev. 1989 Apr; 3(4):559-71. Springer ML, Yanofsky C. PMID: 2524423.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    78. An effective procedure for the preparation of Neurospora crassa conidiophores for scanning electron microscopy. Fungal Genet. Newsl. 1989; 36:78. Springer, ML.