Matt Springer, PhD

Title(s)Professor, Medicine
SchoolSchool of Medicine
Address513 Parnassus Ave, MSB, #1113A
San Francisco CA 94117
ORCID ORCID Icon0000-0002-6689-8234 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UC Berkeley, Berkeley, CABA5/1985Molecular Biology
    Stanford, Stanford, CAPhD1/1992Biological Sciences
    Stanford, Stanford, CAPostdoctoral7/1993Cell Biology/Biochemistry
    Stanford, Stanford, CAPostdoctoral11/1997Molecular Pharmacology

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    Dr. Matthew L. Springer received his BA from the University of California, Berkeley in 1985 and his Ph.D. from Stanford University in 1992. He did postdoctoral research at Stanford and continued his research there as a senior scientist until joining the UCSF faculty in 2003, where he is currently one of three non-clinicians on the faculty of the Division of Cardiology. The close juxtaposition of his basic research background with the clinical cardiologists in the Division has resulted in an active translational research program. Dr. Springer's research interests include cell therapy and gene therapy approaches to studying cardiovascular disease, and a major focus on the adverse effects of tobacco, marijuana, and e-cigarettes on cardiovascular function in rodents and humans.
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    Effects of Chronic Cannabis Use on Endothelial Function
    CA Department of Cannabis Control Grant RG-1603151328-913Jul 1, 2021 - Oct 13, 2023
    Role: Principal Investigator
    Upregulation of SARS-CoV-2 receptor and activation proteases by marijuana smoke and e-cigarette aerosols
    NIH/NIDA R21DA050995-S (supplement)Nov 25, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Validation of NIDA research marijuana as a model for cardiovascular research
    NIH R21DA050995Apr 15, 2020 - Mar 31, 2022
    Role: Principal Investigator
    Models for Prospective Studies of Marijuana's Cardiac Effects
    California Tobacco-Related Disease Research Program T29IP0490Apr 1, 2019 - Mar 31, 2022
    Role: Principal Investigator
    Integrated Health, Behavioral and Economic Research on Current and Emerging Tobacco Products
    NIH/NHLBI U54HL147127Sep 1, 2018 - Jun 30, 2023
    Role: PI of Project 3, Cardiovascular Health Effects of Emerging Heat-Not-Burn Tobacco Products
    Inhibition of Galectin-3 for Therapy of Remodeling After Myocardial Infarction
    NIH R44AG054386Aug 15, 2016 - Mar 31, 2020
    Role: Co-Principal Investigator
    Tobacco/Marijuana Smoke: From Lab to Public Health Policy
    California Tobacco-Related Disease Research Program 393979Jul 1, 2016 - Jun 30, 2019
    Role: Principal Investigator
    Overcoming Impairment of Bone Marrow Cell Therapy for Myocardial Infarction: Role of B Cells
    American Heart Association 15GRNT22590001Jan 1, 2015 - Dec 31, 2017
    Role: Principal Investigator
    Measuring relative cardiovascular health risks of inhaled tobacco products
    NIH R01HL120062Jun 1, 2014 - May 31, 2019
    Role: Principal Investigator
    Protein inhibitor of galectin-3 to limit fibrosis after myocardial infarction
    NIH R43HL120645Sep 4, 2013 - Dec 31, 2014
    Role: Co-Principal Investigator
    Evaluation of harmful effects of cannabis smoke on vascular endothelial function
    NIH R21DA031966Sep 15, 2011 - Jun 30, 2014
    Role: Principal Investigator
    Angiogenesis in Moving Cardiac Tissue: Influence of Motion on Endothelial Pattern Formation and Gene Expression
    American Heart Association Innovative Research Grant 11IRG5250021Jan 1, 2011 - Dec 31, 2013
    Role: Principal Investigator
    Bone marrow cell therapy for cardiac disease: Impact of donor age and infarction
    NIH R21HL097129Jul 1, 2010 - Jun 30, 2012
    Role: Principal Investigator
    Long-Term Vascular Effects of Second Hand Smoke
    Flight Attendant Medical Research Institute 072131Jul 1, 2008 - Jun 30, 2011
    Role: Principal Investigator
    The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function
    NIH R01HL086917Aug 1, 2007 - Jun 30, 2013
    Role: Principal Investigator
    Closed-Chest Cell Injections into Mouse Myocardium Targeted by Ultrasound
    NIH R03EB005802Sep 15, 2005 - Aug 31, 2007
    Role: Principal Investigator
    Pleiotrophin Gene Delivery for Therapeutic Angiogenesis of Ischemic Heart and Limb
    American Heart Association Scientist Development Grant 0535244NJul 1, 2005 - Jun 30, 2009
    Role: Principal Investigator
    NIH F32HL008991Mar 26, 1994
    Role: Co-Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Emerging ENDS products and challenges in tobacco control toxicity research. Tob Control. 2024; 33(1):110-115. Strongin, R.M., Sharma, E., Erythropel, H.C., El-Hellani, A., Kassem, N.O.F., Mikheev, V.B., Noël, A., Peyton, D.H., Springer, M.L. View Publication.
    2. Impairment of Endothelial Function by Aerosol From Marijuana Leaf Vaporizers. J Am Heart Assoc. 2023 Dec 05; 12(23):e032969. Liu J, Nabavizadeh P, Rao P, Derakhshandeh R, Han DD, Guo R, Murphy MB, Cheng J, Schick SF, Springer ML. PMID: 38014661; PMCID: PMC10727338.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Inhibition of galectin-3 post-infarction impedes progressive fibrosis by regulating inflammatory profibrotic cascades. Cardiovasc Res. 2023 11 25; 119(15):2536-2549. Wang X, Gaur M, Mounzih K, Rodriguez HJ, Qiu H, Chen M, Yan L, Cooper BA, Narayan S, Derakhshandeh R, Rao P, Han DD, Nabavizadeh P, Springer ML, John CM. PMID: 37602717; PMCID: PMC10676456.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    4. Local decorin delivery via hyaluronic acid microrods improves cardiac performance, ventricular remodeling after myocardial infarction. NPJ Regen Med. 2023 Oct 23; 8(1):60. Mohindra P, Zhong JX, Fang Q, Cuylear DL, Huynh C, Qiu H, Gao D, Kharbikar BN, Huang X, Springer ML, Lee RJ, Desai TA. PMID: 37872196; PMCID: PMC10593781.
      View in: PubMed   Mentions: 1  
    5. Impairment of Endothelial Function by Cigarette Smoke and e-Cigarette Aerosol Requires RAGE. Arterioscler Thromb Vasc Biol. 2023 12; 43(12):2369-2371. Han DD, Rao P, Qiu H, Navabzadeh M, Wang X, Goyal N, Mohammadi L, Huang A, Perez BG, Schick SF, Springer ML. PMID: 37795616; PMCID: PMC10841038.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    6. Increased vulnerability to atrial and ventricular arrhythmias caused by different types of inhaled tobacco or marijuana products. Heart Rhythm. 2023 01; 20(1):76-86. Qiu H, Zhang H, Han DD, Derakhshandeh R, Wang X, Goyal N, Navabzadeh M, Rao P, Wilson EE, Mohammadi L, Olgin JE, Springer ML. PMID: 36603937; PMCID: PMC10006068.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    7. Impairment of Endothelial Function by Cigarette Smoke Is Not Caused by a Specific Smoke Constituent, but by Vagal Input From the Airway. Arterioscler Thromb Vasc Biol. 2022 11; 42(11):1324-1332. Nabavizadeh P, Liu J, Rao P, Ibrahim S, Han DD, Derakhshandeh R, Qiu H, Wang X, Glantz SA, Schick SF, Springer ML. PMID: 36288292; PMCID: PMC9616206.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsPHPublic Health
    8. Chronic E-Cigarette Use Impairs Endothelial Function on the Physiological and Cellular Levels. Arterioscler Thromb Vasc Biol. 2022 11; 42(11):1333-1350. Mohammadi L, Han DD, Xu F, Huang A, Derakhshandeh R, Rao P, Whitlatch A, Cheng J, Keith RJ, Hamburg NM, Ganz P, Hellman J, Schick SF, Springer ML. PMID: 36288290; PMCID: PMC9625085.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    9. Comparable Impairment of Vascular Endothelial Function by a Wide Range of Electronic Nicotine Delivery Devices. Nicotine Tob Res. 2022 06 15; 24(7):1055-1062. Rao P, Han DD, Tan K, Mohammadi L, Derakhshandeh R, Navabzadeh M, Goyal N, Springer ML. PMID: 35100430; PMCID: PMC9199952.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    10. Letter to the Editor. Am J Infect Control. 2021 04; 49(4):530-531. Springer ML. PMID: 33577825; PMCID: PMC7872845.
      View in: PubMed   Mentions: 1     Fields:    
    11. Impaired therapeutic efficacy of bone marrow cells from post-myocardial infarction patients in the TIME and LateTIME clinical trials. PLoS One. 2020; 15(8):e0237401. Wang X, Chacon LI, Derakhshandeh R, Rodriguez HJ, Han DD, Kostyushev DS, Henry TD, Traverse JH, Moyé L, Simari RD, Taylor DA, Springer ML. PMID: 32841277; PMCID: PMC7446972.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    12. JUUL and Combusted Cigarettes Comparably Impair Endothelial Function. Tob Regul Sci. 2020 Jan; 6(1):30-37. Rao P, Liu J, Springer ML. PMID: 31930162; PMCID: PMC6953758.
      View in: PubMed   Mentions: 48  
    13. Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells. J Am Coll Cardiol. 2019 06 04; 73(21):2722-2737. Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC. PMID: 31146818; PMCID: PMC6637948.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    14. Vascular endothelial function is impaired by aerosol from a single IQOS HeatStick to the same extent as by cigarette smoke. Tob Control. 2018 11; 27(Suppl 1):s13-s19. Nabavizadeh P, Liu J, Havel CM, Ibrahim S, Derakhshandeh R, Jacob Iii P, Springer ML. PMID: 30206183; PMCID: PMC6202192.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    15. Age-Related Impaired Efficacy of Bone Marrow Cell Therapy for Myocardial Infarction Reflects a Decrease in B Lymphocytes. Mol Ther. 2018 07 05; 26(7):1685-1693. An S, Wang X, Ruck MA, Rodriguez HJ, Kostyushev DS, Varga M, Luu E, Derakhshandeh R, Suchkov SV, Kogan SC, Hermiston ML, Springer ML. PMID: 29914756; PMCID: PMC6036225.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    16. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 07 01; 315(1):L25-L40. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. PMID: 29543040; PMCID: PMC6087899.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCellsPHPublic Health
    17. Marijuana, Secondhand Smoke, and Social Acceptability. JAMA Intern Med. 2018 01 01; 178(1):13-14. Glantz SA, Halpern-Felsher B, Springer ML. PMID: 29159409; PMCID: PMC9635842.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsPHPublic Health
    18. One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function. J Am Heart Assoc. 2016 07 27; 5(8). Wang X, Derakhshandeh R, Liu J, Narayan S, Nabavizadeh P, Le S, Danforth OM, Pinnamaneni K, Rodriguez HJ, Luu E, Sievers RE, Schick SF, Glantz SA, Springer ML. PMID: 27464788; PMCID: PMC5015303.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsPHPublic Health
    19. San Francisco Medicine. CANNABIS: Clearing some smoke?. 2016; 2(89):26. Springer ML. View Publication.
    20. Circulating angiogenic cell function is inhibited by cortisol in vitro and associated with psychological stress and cortisol in vivo. Psychoneuroendocrinology. 2016 May; 67:216-23. Aschbacher K, Derakhshandeh R, Flores AJ, Narayan S, Mendes WB, Springer ML. PMID: 26925833; PMCID: PMC4808379.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    21. Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction. J Am Heart Assoc. 2016 Jan 06; 5(1). Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML. PMID: 26738788; PMCID: PMC4859354.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    22. Impairment of Endothelial Function by Little Cigar Secondhand Smoke. Tob Regul Sci. 2016 Jan 01; 2(1):56-63. Liu J, Wang X, Narayan S, Glantz SA, Schick SF, Springer ML. PMID: 26753171; PMCID: PMC4703945.
      View in: PubMed   Mentions: 8  
    23. Protein engineering to develop a redox insensitive endothelial nitric oxide synthase. Redox Biol. 2014; 2C:156-164. Rafikov R, Kumar S, Aggarwal S, Pardo D, Fonseca FV, Ransom J, Rafikova O, Chen Q, Springer ML, Black SM. View Publication.
    24. Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function. Nicotine Tob Res. 2014 May; 16(5):584-90. Pinnamaneni K, Sievers RE, Sharma R, Selchau AM, Gutierrez G, Nordsieck EJ, Su R, An S, Chen Q, Wang X, Derakhshandeh R, Aschbacher K, Heiss C, Glantz SA, Schick SF, Springer ML. PMID: 24302638; PMCID: PMC3977486.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsPHPublic Health
    25. Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients. Br J Nutr. 2014 Apr 14; 111(7):1245-52. Horn P, Amabile N, Angeli FS, Sansone R, Stegemann B, Kelm M, Springer ML, Yeghiazarians Y, Schroeter H, Heiss C. PMID: 24286443.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    26. Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants. PLoS One. 2013; 8(4):e61413. Fang Q, Mok PY, Thomas AE, Haddad DJ, Saini SA, Clifford BT, Kapasi NK, Danforth OM, Usui M, Ye W, Luu E, Sharma R, Bartel MJ, Pathmanabhan JA, Ang AA, Sievers RE, Lee RJ, Springer ML. PMID: 23630585; PMCID: PMC3632611.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    27. Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo. J Appl Physiol (1985). 2013 Mar 15; 114(6):752-60. Chen Q, Sievers RE, Varga M, Kharait S, Haddad DJ, Patton AK, Delany CS, Mutka SC, Blonder JP, Dubé GP, Rosenthal GJ, Springer ML. PMID: 23349456; PMCID: PMC3615603.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    28. Gene therapy and angiogenesis. Cardiology: An Illustrated Textbook. K. Chatterjee et al., eds. 2013; 2013-2029. Springer ML.
    29. Earthquake safety at work: An important topic to review with patients. San Francisco Medicine. 2012; 85(9):12-13. Springer ML. View Publication.
    30. Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair. Sci Transl Med. 2012 Aug 08; 4(146):146ra109. Lin YD, Luo CY, Hu YN, Yeh ML, Hsueh YC, Chang MY, Tsai DC, Wang JN, Tang MJ, Wei EI, Springer ML, Hsieh PC. PMID: 22875829.
      View in: PubMed   Mentions: 62     Fields:    Translation:Animals
    31. Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. J Tissue Sci Eng. 2011 Nov 18; S3. Wang X, Takagawa J, Haddad DJ, Pinnamaneni K, Zhang Y, Sievers RE, Grossman W, Yeghiazarians Y, Springer ML. PMID: 22675670; PMCID: PMC3366554.
      View in: PubMed   Mentions: 7  
    32. Blunting half of the double-edged sword: potential use of interleukin-10 to protect bone marrow-derived cells after myocardial infarction. Circ Res. 2011 Nov 11; 109(11):1196-8. Springer ML, Wang X. PMID: 22076503.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    33. Higher fasting glucose levels are associated with reduced circulating angiogenic cell migratory capacity among healthy individuals. Am J Cardiovasc Dis. 2012; 2(1):12-9. Aschbacher K, Chen Q, Varga M, Haddad DJ, Yeghiazarians Y, Epel E, Wolkowitz OM, Springer ML. PMID: 22254209; PMCID: PMC3257152.
      View in: PubMed   Mentions: 4  
    34. Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med. 2011 Sep 14; 3(100):100ra90. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML. PMID: 21918107; PMCID: PMC3350804.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    35. Nitric oxide counters the inhibitory effects of uremic toxin indoxyl sulfate on endothelial cells by governing ERK MAP kinase and myosin light chain activation. Biochem Biophys Res Commun. 2011 Jun 17; 409(4):758-63. Kharait S, Haddad DJ, Springer ML. PMID: 21621512; PMCID: PMC3121259.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    36. Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Cardiovasc Pathol. 2011; 20:204-212. Zhang Y, Sievers RE, Prasad M, Mirsky R, Shih H, Wong ML, Angeli FS, Ye J, Takagawa J, Koskenvuo JW, Springer ML, Grossman W, Boyle AJ, Yeghiazarians Y.
    37. The launch of American Journal of Cardiovascular Disease. Am J Cardiovasc Dis. 2011; 1:i-ii. Roberts WC, Springer ML, Wang X, Wang D.
    38. Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2212-8. Heiss C, Schanz A, Amabile N, Jahn S, Chen Q, Wong ML, Rassaf T, Heinen Y, Cortese-Krott M, Grossman W, Yeghiazarians Y, Springer ML. PMID: 20705916; PMCID: PMC2959135.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    39. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 2010 Jul 13; 56(3):218-24. Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y. PMID: 20620742.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    40. Assessment of myocardial angiogenesis and vascularity in small animal models. Methods Mol Biol. 2010; 660:149-67. Springer ML. PMID: 20680818.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    41. Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther. 2009 Jul; 17(7):1250-6. Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. PMID: 19384293; PMCID: PMC2835212.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    42. Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Biol. 2008 Sep; 28(9):1614-20. Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau HM, Alitalo K, Eriksson U, Carmeliet P, Moons L. PMID: 18511699; PMCID: PMC2753879.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    43. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol. 2008 May 06; 51(18):1760-71. Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y. PMID: 18452782.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansCellsPHPublic Health
    44. Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells. J Cell Physiol. 2008 May; 215(2):366-73. Heiss C, Wong ML, Block VI, Lao D, Real WM, Yeghiazarians Y, Lee RJ, Springer ML. PMID: 17960557; PMCID: PMC2697332.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    45. Living both music and medicine: Where the two practices intersect. (One of several sections.). San Francisco Medicine. 2008; 81(2):38-39. Springer ML. View Publication.
    46. In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H1086-93. Heiss C, Sievers RE, Amabile N, Momma TY, Chen Q, Natarajan S, Yeghiazarians Y, Springer ML. PMID: 18055528.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    47. Abstract 1421: In Vivo Measurement of Flow-Mediated Vasodilation in Living Rats using High Resolution Ultrasound: Age-Dependent Endothelial Dysfunction. Circulation. 2007 Oct 16; 116(suppl_16). Heiss HC, Sievers SR, Amabile AN, Momma MT, Natarajan NS, Yeghiazarians YY, Springer SM. .
      View in: Publisher Site   Mentions:
    48. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. J Appl Physiol (1985). 2007 Jun; 102(6):2104-11. Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. PMID: 17347379; PMCID: PMC2675697.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimals
    49. Localization of vascular response to VEGF is not dependent on heparin binding. FASEB J. 2007 Jul; 21(9):2074-85. Springer ML, Banfi A, Ye J, von Degenfeld G, Kraft PE, Saini SA, Kapasi NK, Blau HM. PMID: 17325231.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    50. Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H1187-92. Zhang Y, Takagawa J, Sievers RE, Khan MF, Viswanathan MN, Springer ML, Foster E, Yeghiazarians Y. PMID: 17028161.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    51. A balancing act: therapeutic approaches for the modulation of angiogenesis. Curr Opin Investig Drugs. 2006 Mar; 7(3):243-50. Springer ML. PMID: 16555684.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    52. Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia. FASEBJ. 2006; 20(14):2657-9. von Degenfeld G, Banfi A, Springer ML, Wagner RA, Jacobi J, Ozawa CR, Merchant MJ, Cooke JP, Blau HM.
    53. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H560-76. Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald DM. PMID: 16172168.
      View in: PubMed   Mentions: 318     Fields:    Translation:AnimalsCells
    54. Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1307-14. Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y. PMID: 15908468.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    55. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest. 2004 Feb; 113(4):516-27. Ozawa CR, Banfi A, Glazer NL, Thurston G, Springer ML, Kraft PE, McDonald DM, Blau HM. PMID: 14966561; PMCID: PMC338257.
      View in: PubMed   Mentions: 187     Fields:    Translation:AnimalsCells
    56. Myoblast-mediated gene transfer for therapeutic angiogenesis and arteriogenesis. Br J Pharmacol. 2003 Oct; 140(4):620-6. von Degenfeld G, Banfi A, Springer ML, Blau HM. PMID: 14534145; PMCID: PMC1574078.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    57. Localized arteriole formation directly adjacent to the site of VEGF-induced angiogenesis in muscle. Mol Ther. 2003 Apr; 7(4):441-9. Springer ML, Ozawa CR, Banfi A, Kraft PE, Ip TK, Brazelton TR, Blau HM. PMID: 12727106.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    58. RIP2, a checkpoint in myogenic differentiation. Mol Cell Biol. 2002 Aug; 22(16):5879-86. Munz B, Hildt E, Springer ML, Blau HM. PMID: 12138198; PMCID: PMC133983.
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    59. Transient production of alpha-smooth muscle actin by skeletal myoblasts during differentiation in culture and following intramuscular implantation. Cell Motil Cytoskeleton. 2002 Apr; 51(4):177-86. Springer ML, Ozawa CR, Blau HM. PMID: 11977092.
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    60. VEGF therapy in heart disease: for better or for worse? Drug Discov Today. 2002 Feb 15; 7(4):209-11. Springer ML. PMID: 11839510.
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    61. Gene delivery to muscle. Curr Protoc Hum Genet. 2002 Feb; Chapter 13:Unit13.4. Springer ML, Rando TA, Blau HM. PMID: 18428326.
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    62. Myoblast-mediated gene transfer for therapeutic angiogenesis. Methods Enzymol. 2002; 346:145-57. Banfi A, Springer ML, Blau HM. PMID: 11883066.
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    63. Not the usual suspects: the unexpected sources of tissue regeneration. J Clin Invest. 2001 Jun; 107(11):1355-6. Springer ML, Brazelton TR, Blau HM. PMID: 11390416; PMCID: PMC209330.
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    64. VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation. 2000 Aug 22; 102(8):898-901. Lee RJ, Springer ML, Blanco-Bose WE, Shaw R, Ursell PC, Blau HM. PMID: 10952959.
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    65. Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor. J Gene Med. 2000 Jul-Aug; 2(4):279-88. Springer ML, Hortelano G, Bouley DM, Wong J, Kraft PE, Blau HM. PMID: 10953919.
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    66. Ex vivo gene therapy using myoblasts and regulatable retroviral vectors. In Gene Therapy: Therapeutic Mechanisms and Strategies, NS Templeton and DD Lasic, eds. 2000; 61-80. Ozawa CR, Springer ML, Blau HM.
    67. Angiogenesis monitored by perfusion with a space-filling microbead suspension. Mol Ther. 2000 Jan; 1(1):82-7. Springer ML, Ip TK, Blau HM. PMID: 10933915.
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    68. A novel means of drug delivery: myoblast-mediated gene therapy and regulatable retroviral vectors. Annu Rev Pharmacol Toxicol. 2000; 40:295-317. Ozawa CR, Springer ML, Blau HM. PMID: 10836138.
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    69. Analysis of immune responses to varicella zoster viral proteins induced by DNA vaccination. Antiviral Res. 1999 Dec 31; 44(3):179-92. Abendroth A, Slobedman B, Springer ML, Blau HM, Arvin AM. PMID: 10651069.
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    70. VEGF gene delivery to muscle: potential role for vasculogenesis in adults. Mol Cell. 1998 Nov; 2(5):549-58. Springer ML, Chen AS, Kraft PE, Bednarski M, Blau HM. PMID: 9844628.
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    71. Inhibition of solid tumor growth by Fas ligand-expressing myoblasts. Somat Cell Mol Genet. 1998 Sep; 24(5):281-9. Springer ML, Kraft PE, Blau HM. PMID: 10696236.
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    72. Immune response and myoblasts that express Fas ligand. Science. 1997 Nov 14; 278(5341):1322-4. Kang SM, Hoffmann A, Le D, Springer ML, Stock PG, Blau HM. PMID: 9411754.
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    73. High-efficiency retroviral infection of primary myoblasts. Somat Cell Mol Genet. 1997 May; 23(3):203-9. Springer ML, Blau HM. PMID: 9330631.
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    74. Towards a treatment for Tay-Sachs disease. Molec. Med. Today. 1996; 2:232. Springer, ML.
    75. Muscle-mediated gene therapy. N Engl J Med. 1995 Dec 07; 333(23):1554-6. Blau HM, Springer ML. PMID: 7477172.
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    76. Gene therapy--a novel form of drug delivery. N Engl J Med. 1995 Nov 02; 333(18):1204-7. Blau HM, Springer ML. PMID: 7565977.
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    77. Cell implantation treatment for MPS VII. Molec. Med. Today. 1995; 1:111. Springer, ML.
    78. Gene therapy for restenosis: retinoblastoma to the rescue. Molec. Med. Today. 1995; 1:57. Springer, ML.
    79. Stage-specific requirement for myosin II during Dictyostelium development. Development. 1994 Sep; 120(9):2651-60. Springer ML, Patterson B, Spudich JA. PMID: 7956839.
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    80. Genetic control of fungal differentiation: the three sporulation pathways of Neurospora crassa. Bioessays. 1993 Jun; 15(6):365-74. Springer ML. PMID: 8357339.
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    81. Timing of synthesis and cellular localization of two conidiation-specific proteins of Neurospora crassa. Dev Biol. 1992 Aug; 152(2):255-62. Springer ML, Hager KM, Garrett-Engele C, Yanofsky C. PMID: 1386581.
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    82. Expression of con genes along the three sporulation pathways of Neurospora crassa. Genes Dev. 1992 Jun; 6(6):1052-7. Springer ML, Yanofsky C. PMID: 1534304.
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    83. Tergitol-induced colonial growth without inhibition of conidiation. Fungal Genet. Newsl. 1991; 38:92. Springer, ML.
    84. A morphological and genetic analysis of conidiophore development in Neurospora crassa. Genes Dev. 1989 Apr; 3(4):559-71. Springer ML, Yanofsky C. PMID: 2524423.
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    85. An effective procedure for the preparation of Neurospora crassa conidiophores for scanning electron microscopy. Fungal Genet. Newsl. 1989; 36:78. Springer, ML.