Anthony Wong, MD, PhD

Title(s)Associate Professor, Radiation Oncology
SchoolSchool of Medicine
Address1825 4th Street, #L1132B
San Francisco CA 94107
Phone415-353-8975
ORCID ORCID Icon0000-0002-9288-061X Additional info
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    Collapse Biography 
    Collapse Education and Training
    Yale University, New Haven, CTBS05/2004Molecular Biophysics and Biochemistry
    Albert Einstein College of Medicine, Bronx, NYMD, PhD05/2012Biomedical Sciences
    Memorial Sloan Kettering Cancer Center, New York, NY06/2013Transitional Year Internship
    University of Chicago, Chicago, IL06/2017Radiation Oncology Residency

    Collapse Overview 
    Collapse Overview
    I am a board-certified radiation oncologist specializing in management of genitourinary malignancies, including prostate, bladder, renal, and testicular malignancies. My clinical areas of expertise include high dose rate (HDR) prostate brachytherapy, stereotactic body radiation therapy (SBRT), and bladder-preserving trimodality therapy.

    My research interests involve using new technologies, such as advanced imaging and genomic analysis, to improve radiation therapy for genitourinary malignancies. For example, in collaboration with the department of radiology, I am utilizing PSMA PET to map patterns of prostate cancer progression and relapse in the newly diagnosed and post-treatment settings. I am also investigating the use of HDR prostate brachytherapy in technically challenging scenarios, including patients with a prior history of transurethral resection of the prostate and patients who previously received pelvic radiation.

    With regards to ongoing clinical trials, I am the radiation oncology site primary investigator for the UCSF institutional clinical trial investigating prostate SBRT and immunotherapy for newly diagnosed oligometastatic prostate cancer (CC#16703). I am the site PI for the FORMULA-509 trial (CC#18551), a multicenter randomized trial evaluating the use of apalutamide and abiraterone during post-prostatectomy salvage radiation therapy for prostate cancer patients with high-risk features. I am the site PI for NRG Oncology RTOG 3506 clinical trial evaluating the use of enzalutamide in patients during post-prostatectomy salvage radiation therapy for prostate cancer patients with high-risk features. In collaboration with UCSF and SFVA pathology departments, I am investigating the genomic landscape of variant histology prostate cancers in the interest of developing novel therapeutics.

    I am interested in expanding the use of ablative radiation techniques. In collaboration with colleagues in the department of cardiology, I am working to bring a stereotactic body radiation therapy program for refractory ventricular arrhythmias to UCSF.

    Collapse Research 
    Collapse Research Activities and Funding
    Hyperpolarized C-13 MRI Techniques to Monitor Radiation Therapy Response in Prostate Cancer Patients
    NIH R01CA238379Jul 1, 2021 - Jun 30, 2026
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Featured Publications

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Long-term Prostate Cancer-specific Mortality After Prostatectomy, Brachytherapy, External Beam Radiation Therapy, Hormonal Therapy, or Monitoring for Localized Prostate Cancer. Eur Urol. 2023 Oct 17. Herlemann A, Cowan JE, Washington SL, Wong AC, Broering JM, Carroll PR, Cooperberg MR. PMID: 37858454.
      View in: PubMed   Mentions: 1     Fields:    
    2. Impact of Squamous Histology on Clinical Outcomes and Molecular Profiling in Metastatic Urothelial Carcinoma Patients Treated With Immune Checkpoint Inhibitors or Enfortumab Vedotin. Clin Genitourin Cancer. 2023 10; 21(5):e394-e404. Jindal T, Zhang L, Deshmukh P, Reyes K, Chan E, Kumar V, Zhu X, Maldonado E, Feng S, Johnson M, Angelidakis A, Kwon D, Desai A, Borno HT, Bose R, Wong A, Hong J, Carroll P, Meng M, Porten S, Aggarwal R, Small EJ, Fong L, Chou J, Friedlander T, de Kouchkovsky I, Koshkin VS. PMID: 37316414.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Somatic alterations of TP53 and MDM2 associated with response to enfortumab vedotin in patients with advanced urothelial cancer. Front Oncol. 2023; 13:1161089. Jindal T, Zhu X, Bose R, Kumar V, Maldonado E, Deshmukh P, Shipp C, Feng S, Johnson MS, Angelidakis A, Kwon D, Borno HT, de Kouchkovsky I, Desai A, Aggarwal R, Fong L, Small EJ, Wong A, Porten S, Chou J, Friedlander T, Koshkin VS. PMID: 37091148; PMCID: PMC10113661.
      View in: PubMed   Mentions:
    4. Outcomes of salvage high dose-rate brachytherapy with or without pelvic external beam radiotherapy in patients with palpable local recurrence of prostate cancer after radical prostatectomy. Brachytherapy. 2023 May-Jun; 22(3):304-309. Ni L, Chen K, Phuong C, Sabbagh AR, Wong AC, Mohamad O, Hsu IC. PMID: 36623988.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Painless Rectal Bleeding in a Patient With Prostate Cancer. Gastroenterology. 2022 11; 163(5):1176-1178. Medina SP, Wong AC, El-Nachef N. PMID: 35777477.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Addition of Enzalutamide to Leuprolide and Definitive Radiation Therapy Is Tolerable and Effective in High-Risk Localized or Regional Nonmetastatic Prostate Cancer: Results From a Phase 2 Trial. Adv Radiat Oncol. 2022 Sep-Oct; 7(5):100941. Shee K, de la Calle CM, Chang AJ, Wong AC, Feng FY, Gottschalk AR, Carroll PR, Nguyen HG. PMID: 35847550; PMCID: PMC9280039.
      View in: PubMed   Mentions: 1  
    7. APOBEC Mutational Signature and Tumor Mutational Burden as Predictors of Clinical Outcomes and Treatment Response in Patients With Advanced Urothelial Cancer. Front Oncol. 2022; 12:816706. Natesan D, Zhang L, Martell HJ, Jindal T, Devine P, Stohr B, Espinosa-Mendez C, Grenert J, Van Ziffle J, Joseph N, Umetsu S, Onodera C, Turski M, Chan E, Desai A, Aggarwal R, Wong A, Porten S, Chou J, Friedlander T, Fong L, Small EJ, Sweet-Cordero A, Koshkin VS. PMID: 35321431; PMCID: PMC8935010.
      View in: PubMed   Mentions: 3  
    8. Safety of accelerated hypofractionated whole pelvis radiation therapy prior to high dose rate brachytherapy or stereotactic body radiation therapy prostate boost. Radiat Oncol. 2022 Jan 20; 17(1):12. Phuong C, Chan JW, Ni L, Wall P, Mohamad O, Wong AC, Hsu IC, Chang AJ. PMID: 35057827; PMCID: PMC8772149.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    9. Molecular risk classifier score and biochemical recurrence risk are associated with cribriform pattern type in Gleason 3+4=7 prostate cancer. Investig Clin Urol. 2022 01; 63(1):27-33. Greenland NY, Cooperberg MR, Wong AC, Chan E, Carroll PR, Simko JP, Stohr BA. PMID: 34983120; PMCID: PMC8756156.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    10. Salvage High-Dose-Rate Brachytherapy for Recurrent Prostate Cancer After Definitive Radiation. Pract Radiat Oncol. 2021 Nov-Dec; 11(6):515-526. Wu SY, Wong AC, Shinohara K, Roach M, Cunha JAM, Valdes G, Hsu IC. PMID: 34077809.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. TERT promoter mutations and other prognostic factors in patients with advanced urothelial carcinoma treated with an immune checkpoint inhibitor. J Immunother Cancer. 2021 05; 9(5). de Kouchkovsky I, Zhang L, Philip EJ, Wright F, Kim DM, Natesan D, Kwon D, Ho H, Ho S, Chan E, Porten SP, Wong AC, Desai A, Huang FW, Chou J, Oh DY, Pruthi RS, Fong L, Small EJ, Friedlander TW, Koshkin VS. PMID: 33980590; PMCID: PMC8118032.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    12. Prostate-specific Membrane Antigen and Fluciclovine Transporter Genes are Associated with Variable Clinical Features and Molecular Subtypes of Primary Prostate Cancer. Eur Urol. 2021 06; 79(6):717-721. Chu CE, Alshalalfa M, Sjöström M, Zhao SG, Liu Y, Chou J, Herlemann A, Mahal B, Kishan AU, Spratt DE, Cooperberg M, Small E, Wong A, Porten S, Hope TA, Ross AE, Davicioni E, Nguyen P, Karnes RJ, Carroll PR, Schaeffer E, Feng FY. PMID: 33840559.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    13. Development and Validation of a Genomic Tool to Predict Seminal Vesicle Invasion in Adenocarcinoma of the Prostate. JCO Precis Oncol. 2020 Nov; 4:1228-1238. Hall WA, Fishbane N, Liu Y, Xu MJ, Davicioni E, Mahal BA, Den RB, Dess RT, Jackson WC, Wong AC, Schaeffer EM, Karnes RJ, Carroll PR, Cooperberg MR, Bismar TA, Kim HL, Klein EA, Davis JW, Ross AE, Tosoian JJ, Morgan TM, Mehra R, Salami SS, Nguyen PL, Lawton CAF, Spratt DE, Feng F. PMID: 35050780.
      View in: PubMed   Mentions: 2     Fields:    
    14. A Virion-Based Assay for Glycoprotein Thermostability Reveals Key Determinants of Filovirus Entry and Its Inhibition. J Virol. 2020 08 31; 94(18). Bortz RH, Wong AC, Grodus MG, Recht HS, Pulanco MC, Lasso G, Anthony SJ, Mittler E, Jangra RK, Chandran K. PMID: 32611759; PMCID: PMC7459555.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. NRG Oncology Updated International Consensus Atlas on Pelvic Lymph Node Volumes for Intact and Postoperative Prostate Cancer. Int J Radiat Oncol Biol Phys. 2021 01 01; 109(1):174-185. Hall WA, Paulson E, Davis BJ, Spratt DE, Morgan TM, Dearnaley D, Tree AC, Efstathiou JA, Harisinghani M, Jani AB, Buyyounouski MK, Pisansky TM, Tran PT, Karnes RJ, Chen RC, Cury FL, Michalski JM, Rosenthal SA, Koontz BF, Wong AC, Nguyen PL, Hope TA, Feng F, Sandler HM, Lawton CAF. PMID: 32861817; PMCID: PMC7736505.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    16. Noninvasive ventricular tachycardia ablation: Should we apply the accelerator or the brake? Heart Rhythm. 2020 08; 17(8):1249-1250. Dewland TA, Wong AC, Gerstenfeld EP. PMID: 32289468.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    17. Histological features and prognostic significance of treatment effect in lymph node metastasis in head and neck squamous cell carcinoma. Histopathology. 2019 Jan; 74(2):321-331. Scherpelz KP, Wong AC, Lingen MW, Taxy JB, Cipriani NA. PMID: 30144145.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Late toxicity after post-prostatectomy intensity modulated radiation therapy: Evaluating normal-tissue sparing guidelines. Adv Radiat Oncol. 2018 Jul-Sep; 3(3):339-345. Akthar AS, Wong AC, Parekh AD, Hubert G, Son CH, Pelizzari CA, Liauw SL. PMID: 30202803; PMCID: PMC6128032.
      View in: PubMed   Mentions: 5  
    19. PMRT: Please Mind Randomized Trials. Int J Radiat Oncol Biol Phys. 2017 08 01; 98(5):976-977. Wong AC, Chmura SJ. PMID: 28721908.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    20. A feasibility study of 2-mm bolus for postmastectomy radiation therapy. Pract Radiat Oncol. 2017 May - Jun; 7(3):161-166. Das LC, Golden DW, Perevalova E, Wong AC, De Nardo K, Stepaniak C, Joyce DS, McCabe BP, Hasan Y, Chmura SJ, McCall A. PMID: 28089526.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    21. Clinical and molecular markers of long-term survival after oligometastasis-directed stereotactic body radiotherapy (SBRT). Cancer. 2016 07 15; 122(14):2242-50. Wong AC, Watson SP, Pitroda SP, Son CH, Das LC, Stack ME, Uppal A, Oshima G, Khodarev NN, Salama JK, Weichselbaum RR, Chmura SJ. PMID: 27206146.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    22. Cancer therapies activate RIG-I-like receptor pathway through endogenous non-coding RNAs. Oncotarget. 2016 May 03; 7(18):26496-515. Ranoa DR, Parekh AD, Pitroda SP, Huang X, Darga T, Wong AC, Huang L, Andrade J, Staley JP, Satoh T, Akira S, Weichselbaum RR, Khodarev NN. PMID: 27034163; PMCID: PMC5041995.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    23. Physicians' beliefs about the benefits and risks of adjuvant therapies for stage II and stage III colorectal cancer. J Oncol Pract. 2014 Sep; 10(5):e360-7. Wong AC, Stock S, Schrag D, Kahn KL, Salz T, Charlton ME, Rogers SO, Goodman KA, Keating NL. PMID: 24986112; PMCID: PMC4161733.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    24. Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation. PLoS One. 2013; 8(6):e67258. Fang DD, Zhang CC, Gu Y, Jani JP, Cao J, Tsaparikos K, Yuan J, Thiel M, Jackson-Fisher A, Zong Q, Lappin PB, Hayashi T, Schwab RB, Wong A, John-Baptiste A, Bagrodia S, Los G, Bender S, Christensen J, Vanarsdale T. PMID: 23826249; PMCID: PMC3695076.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    25. Contrast agents for quantitative microCT of lung tumors in mice. Comp Med. 2013; 63(6):482-90. Lalwani K, Giddabasappa A, Li D, Olson P, Simmons B, Shojaei F, Van Arsdale T, Christensen J, Jackson-Fisher A, Wong A, Lappin PB, Eswaraka J. PMID: 24326223; PMCID: PMC3866987.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    26. Biomarker and pharmacologic evaluation of the γ-secretase inhibitor PF-03084014 in breast cancer models. Clin Cancer Res. 2012 Sep 15; 18(18):5008-19. Zhang CC, Pavlicek A, Zhang Q, Lira ME, Painter CL, Yan Z, Zheng X, Lee NV, Ozeck M, Qiu M, Zong Q, Lappin PB, Wong A, Rejto PA, Smeal T, Christensen JG. PMID: 22806875.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
    27. Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice. Cancer Chemother Pharmacol. 2012 Aug; 70(2):213-20. Simmons BH, Lee JH, Lalwani K, Giddabasappa A, Snider BA, Wong A, Lappin PB, Eswaraka J, Kan JL, Christensen JG, Shojaei F. PMID: 22684718.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    28. Structural basis for differential neutralization of ebolaviruses. Viruses. 2012 04; 4(4):447-70. Bale S, Dias JM, Fusco ML, Hashiguchi T, Wong AC, Liu T, Keuhne AI, Li S, Woods VL, Chandran K, Dye JM, Saphire EO. PMID: 22590681; PMCID: PMC3347318.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    29. [(18)F]FLT-PET imaging does not always "light up" proliferating tumor cells. Clin Cancer Res. 2012 Mar 01; 18(5):1303-12. Zhang CC, Yan Z, Li W, Kuszpit K, Painter CL, Zhang Q, Lappin PB, Nichols T, Lira ME, Affolter T, Fahey NR, Cullinane C, Spilker M, Zasadny K, O'Brien P, Buckman D, Wong A, Christensen JG. PMID: 22170262.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimals
    30. A shared structural solution for neutralizing ebolaviruses. Nat Struct Mol Biol. 2011 Nov 20; 18(12):1424-7. Dias JM, Kuehne AI, Abelson DM, Bale S, Wong AC, Halfmann P, Muhammad MA, Fusco ML, Zak SE, Kang E, Kawaoka Y, Chandran K, Dye JM, Saphire EO. PMID: 22101933; PMCID: PMC3230659.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    31. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature. 2011 Aug 24; 477(7364):340-3. Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR. PMID: 21866103; PMCID: PMC3175325.
      View in: PubMed   Mentions: 722     Fields:    Translation:HumansAnimalsCells
    32. HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors. Cancer Res. 2010 Dec 15; 70(24):10090-100. Shojaei F, Lee JH, Simmons BH, Wong A, Esparza CO, Plumlee PA, Feng J, Stewart AE, Hu-Lowe DD, Christensen JG. PMID: 20952508.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    33. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. Mol Cancer Ther. 2010 Jun; 9(6):1618-28. Wei P, Walls M, Qiu M, Ding R, Denlinger RH, Wong A, Tsaparikos K, Jani JP, Hosea N, Sands M, Randolph S, Smeal T. PMID: 20530712.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansCells
    34. A forward genetic strategy reveals destabilizing mutations in the Ebolavirus glycoprotein that alter its protease dependence during cell entry. J Virol. 2010 Jan; 84(1):163-75. Wong AC, Sandesara RG, Mulherkar N, Whelan SP, Chandran K. PMID: 19846533; PMCID: PMC2798398.
      View in: PubMed   Mentions: 103     Fields:    Translation:AnimalsCells
    35. Drosophila hnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of the prospero twintron. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2577-82. Borah S, Wong AC, Steitz JA. PMID: 19196985; PMCID: PMC2636732.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    36. The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14114-9. Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ. PMID: 15375216; PMCID: PMC521127.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    37. An intronic enhancer regulates splicing of the twintron of Drosophila melanogaster prospero pre-mRNA by two different spliceosomes. Mol Cell Biol. 2004 Mar; 24(5):1855-69. Scamborova P, Wong A, Steitz JA. PMID: 14966268; PMCID: PMC350559.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
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