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Understanding TCR T cell knockout behavior using interpretable machine learning. Pac Symp Biocomput. 2025; 30:382-393.
Blennemann M, Verma A, Bachl S, Carnevale J, Engelhardt BE. PMID: 39670384.
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HumansCells
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Central control of dynamic gene circuits governs T cell rest and activation. Nature. 2024 Dec 11.
Arce MM, Umhoefer JM, Arang N, Kasinathan S, Freimer JW, Steinhart Z, Shen H, Pham MTN, Ota M, Wadhera A, Dajani R, Dorovskyi D, Chen YY, Liu Q, Zhou Y, Swaney DL, Obernier K, Shy BR, Carnevale J, Satpathy AT, Krogan NJ, Pritchard JK, Marson A. PMID: 39663454.
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Cellular behavior analysis from live-cell imaging of TCR T cell-cancer cell interactions. bioRxiv. 2024 Nov 21.
Verma A, Yu C, Bachl S, Lopez I, Schwartz M, Moen E, Kale N, Ching C, Miller G, Dougherty T, Pao E, Graf W, Ward C, Jena S, Marson A, Carnevale J, Van Valen D, Engelhardt BE. PMID: 39605616; PMCID: PMC11601648.
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CLDN18.2 chimeric antigen receptor T cell therapy for patients with advanced gastric and pancreatic adenocarcinoma: Results of ELIMYN18.2 phase 1b clinical trial. Journal of Clinical Oncology. 2024 Jan 20; 42(3_suppl):356-356.
Botta BG, Kelly KR, Jin JZ, Ma MH, Ku KG, Zhao ZD, Mehta MR, Carnevale CJ, Sierra SG, JIA JJ, Baffa BR, Li LZ, Kim KD, Yoon YH. .
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Ablation of Cullin-5 in Primary Human T Cells Improves Tumor Killing and Persistence in BCMA-Targeting CAR-T Cells in a Multiple Myeloma Model. Blood. 2023 Nov 28; 142(Supplement 1):99.
Bachl BS, Talbot TA, Ching CC, Kale KN, Li LZ, Diolaiti DM, Chen CA, Muldoon MJ, Liu LC, Martin MT, Eyquem EJ, Carnevale CJ. .
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Modular pooled discovery of synthetic knockin sequences to program durable cell therapies. Cell. 2023 09 14; 186(19):4216-4234.e33.
Blaeschke F, Chen YY, Apathy R, Daniel B, Chen AY, Chen PA, Sandor K, Zhang W, Li Z, Mowery CT, Yamamoto TN, Nyberg WA, To A, Yu R, Bueno R, Kim MC, Schmidt R, Goodman DB, Feuchtinger T, Eyquem J, Jimmie Ye C, Carnevale J, Satpathy AT, Shifrut E, Roth TL, Marson A. PMID: 37714135; PMCID: PMC10508323.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Abstract No. 266 Phase I Prospective Trial of TAS-102 (Trifluridine and Tipiracil) and Radioembolization with 90Y Resin Microspheres for Chemo-Refractory Colorectal Liver Metastases. Journal of Vascular and Interventional Radiology. 2023 Mar 1; 34(3):s120.
Fidelman FN, Atreya AC, Griffith GM, Milloy MA, Carnevale CJ, Venook VA, Van Loon VK. .
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Phase I prospective trial of TAS-102 (trifluridine and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases. BMC Cancer. 2022 Dec 13; 22(1):1307.
Fidelman N, Atreya CE, Griffith M, Milloy MA, Carnevale J, Cinar P, Venook AP, Van Loon K. PMID: 36514060; PMCID: PMC9749246.
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PubMed Mentions:
1 Fields:
Translation:
HumansCTClinical Trials
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Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2. Cancer Res. 2022 11 02; 82(21):3950-3961.
O'Leary PC, Chen H, Doruk YU, Williamson T, Polacco B, McNeal AS, Shenoy T, Kale N, Carnevale J, Stevenson E, Quigley DA, Chou J, Feng FY, Swaney DL, Krogan NJ, Kim M, Diolaiti ME, Ashworth A. PMID: 36273492; PMCID: PMC9633439.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature. 2022 09; 609(7925):174-182.
Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Ibañez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A. PMID: 36002574; PMCID: PMC9433322.
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PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence. Cancer Cell. 2022 07 11; 40(7):768-786.e7.
Belk JA, Yao W, Ly N, Freitas KA, Chen YT, Shi Q, Valencia AM, Shifrut E, Kale N, Yost KE, Duffy CV, Daniel B, Hwee MA, Miao Z, Ashworth A, Mackall CL, Marson A, Carnevale J, Vardhana SA, Satpathy AT. PMID: 35750052; PMCID: PMC9949532.
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PubMed Mentions:
109 Fields:
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HumansAnimalsCells
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Phase II study of pembrolizumab plus capecitabine and bevacizumab in microsatellite stable (MSS) metastatic colorectal cancer (mCRC). Journal of Clinical Oncology. 2022 Jun 1; 40(16_suppl):3565-3565.
Bocobo BA, Wang WR, Behr BS, Carnevale CJ, Cinar CP, Collisson CE, Fong FL, Keenan KB, Kidder KW, Ko KA, Kolli KK, Kennedy KM, Laffan LA, Piawah PS, Pollak PM, Schwartz SG, Whitman WJ, Zhang ZL, Van Loon VK, Atreya AC. .
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The Additional Diagnostic Benefit of Pancreatic Cancer Molecular Profiling After Germline Testing. Pancreas. 2022 04 01; 51(4):302-304.
Walker EJ, Blanco AM, Carnevale J, Cinar P, Collisson EA, Tempero MA, Ko AH. PMID: 35695740.
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HumansCells
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Hypoxia Is a Dominant Remodeler of the Effector T Cell Surface Proteome Relative to Activation and Regulatory T Cell Suppression. Mol Cell Proteomics. 2022 04; 21(4):100217.
Byrnes JR, Weeks AM, Shifrut E, Carnevale J, Kirkemo L, Ashworth A, Marson A, Wells JA. PMID: 35217172; PMCID: PMC9006863.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Implementation of an Embedded In-Clinic Genetic Testing Station to Optimize Germline Testing for Patients with Pancreatic Adenocarcinoma. Oncologist. 2021 11; 26(11):e1982-e1991.
Walker EJ, Goldberg D, Gordon KM, Pedley C, Carnevale J, Cinar P, Collisson EA, Tempero MA, Ko AH, Blanco AM, Dhawan M. PMID: 34506673; PMCID: PMC8571767.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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512O Interim results from a phase II study of the ATR inhibitor ceralasertib in ARID1A-deficient and ARID1A-intact advanced solid tumor malignancies. Annals of Oncology. 2021 Sep 1; 32:s583.
Aggarwal AR, Umetsu US, Dhawan DM, Grabowsky GJ, Carnevale CJ, Howell HM, Wilch WL, Chapman CJ, Alvarez AE, Calabrese CS, Smith SS, Shah SN, Dean DE, Munster MP, Collisson CE. .
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Durable response after immune checkpoint inhibitor-related diabetes in mismatch repair-deficient pancreatic cancer. Immunotherapy. 2021 10; 13(15):1249-1254.
Tsang ES, Walker EJ, Carnevale J, Fisher GA, Ko AH. PMID: 34338034.
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PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Investigating tumor molecular profiling as a possible contributor to racial/ethnic disparities in pancreatic cancer. Journal of Clinical Oncology. 2021 May 20; 39(15_suppl):6522-6522.
Walker WE, Piawah PS, Griffin GA, Carnevale CJ, Cinar CP, Collisson CE, Tempero TM, Ko KA. .
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The marginal diagnostic benefit of pancreatic cancer molecular profiling after germline testing. Journal of Clinical Oncology. 2021 May 20; 39(15_suppl):10513-10513.
Walker WE, Blanco BA, Carnevale CJ, Cinar CP, Collisson CE, Tempero TM, Ko KA. .
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Phase II study of pembrolizumab plus capecitabine and bevacizumab in microsatellite stable (MSS) metastatic colorectal cancer (mCRC): Interim analysis. Journal of Clinical Oncology. 2021 Jan 20; 39(3_suppl):77-77.
Bocobo BA, Wang WR, Behr BS, Carnevale CJ, Cinar CP, Collisson CE, Fong FL, Kidder KW, Ko KA, Kolli KK, Kennedy KM, Laffan LA, Lindsay LS, Nalla NS, Schwartz SG, Whitman WJ, Zendejas ZP, Zhang ZL, Van Loon VK, Atreya AC. .
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Combined Immunotherapy and Hypofractionated Radiotherapy for Metastatic Cancers. International Journal of Radiation Oncology • Biology • Physics. 2020 Nov 1; 108(3):e648.
Sinha SS, Greene GC, Kelley KR, Cinar CP, Venook VA, Atreya AC, Gordan GJ, Carnevale CJ, Anwar AM, Feng FM. .
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Abstract PR08: Discovery of immune regulators in primary human T cells using genome-wide CRISPR screens. Cancer Immunology Research. 2020 Apr 1; 8(4_Supplement):pr08-pr08.
Carnevale CJ, Shifrut SE, Tobin TV, Roth RT, Woo WJ, Bui BC, Li LJ, Diolaiti DM, Ashworth AA, Marson MA. .
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3:54 PM Abstract No. 243 Phase I Prospective Trial of TAS-102 (trifluride and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases. Journal of Vascular and Interventional Radiology. 2020 Mar 1; 31(3):s109.
Fidelman FN, Atreya AC, Griffith GM, Milloy MA, Carnevale CJ, Cinar CP, Venook VA, Van Loon VK. .
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Phase I prospective trial of TAS-102 (trifluride and tipiracil) and radioembolization with 90Y resin microspheres for chemo-refractory colorectal liver metastases. Journal of Clinical Oncology. 2020 Feb 1; 38(4_suppl):110-110.
Fidelman FN, Atreya AC, Griffith GM, Milloy MM, Carnevale CJ, Cinar CP, Venook VA, Van Loon VK. .
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Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. The Journal of Immunology. 2019 May 1; 202(1_Supplement):130.6-130.6.
Shifrut SE, Carnevale CJ, Ashworth AA, Marson MA. .
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Referral frequency, attrition rate, and outcomes of germline testing in patients with pancreatic adenocarcinoma. Fam Cancer. 2019 04; 18(2):241-251.
Walker EJ, Carnevale J, Pedley C, Blanco A, Chan S, Collisson EA, Tempero MA, Ko AH. PMID: 30267352.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function. Cell. 2018 12 13; 175(7):1958-1971.e15.
Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A. PMID: 30449619; PMCID: PMC6689405.
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PubMed Mentions:
260 Fields:
Translation:
HumansCells
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Reprogramming human T cell function and specificity with non-viral genome targeting. Nature. 2018 07; 559(7714):405-409.
Roth TL, Puig-Saus C, Yu R, Shifrut E, Carnevale J, Li PJ, Hiatt J, Saco J, Krystofinski P, Li H, Tobin V, Nguyen DN, Lee MR, Putnam AL, Ferris AL, Chen JW, Schickel JN, Pellerin L, Carmody D, Alkorta-Aranburu G, Del Gaudio D, Matsumoto H, Morell M, Mao Y, Cho M, Quadros RM, Gurumurthy CB, Smith B, Haugwitz M, Hughes SH, Weissman JS, Schumann K, Esensten JH, May AP, Ashworth A, Kupfer GM, Greeley SAW, Bacchetta R, Meffre E, Roncarolo MG, Romberg N, Herold KC, Ribas A, Leonetti MD, Marson A. PMID: 29995861; PMCID: PMC6239417.
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PubMed Mentions:
394 Fields:
Translation:
HumansAnimalsCells
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Referral patterns and attrition rate for germline testing in pancreatic cancer (PC) patients. Journal of Clinical Oncology. 2018 May 20; 36(15_suppl):1591-1591.
Walker WE, Carnevale CJ, Pedley PC, Blanco BA, Chan CS, Collisson CE, Ko KA. .
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Targeting the Tumor Microenvironment. Current and Emerging Therapies in Pancreatic Cancer. 2018 Jan 1; 235-256.
Carnevale CJ, Ko KA. .
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Current and Emerging Therapies in Pancreatic Cancer. Editors: Tanios Bekaii-Saab and Bassel Le-Rayes. Targeting the Tumor Microenvironment. 2018; 235-256.
Carnevale J, Ko A.
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The Challenge of Primary Central Nervous System Lymphoma. Hematol Oncol Clin North Am. 2016 Dec; 30(6):1293-1316.
Carnevale J, Rubenstein JL. PMID: 27888882; PMCID: PMC5127405.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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MM-398 (nanoliposomal irinotecan): emergence of a novel therapy for the treatment of advanced pancreatic cancer. Future Oncol. 2016 Feb; 12(4):453-64.
Carnevale J, Ko AH. PMID: 26685802.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Assessing the Significance of BRCA1 and BRCA2 Mutations in Pancreatic Cancer. J Clin Oncol. 2015 Oct 01; 33(28):3080-1.
Carnevale J, Ashworth A. PMID: 25987697.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Exploring the association of succinate dehydrogenase complex mutations with lymphoid malignancies. Fam Cancer. 2014 Sep; 13(3):507-11.
Renella R, Carnevale J, Schneider KA, Hornick JL, Rana HQ, Janeway KA. PMID: 24781345.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Progress in central nervous system lymphomas. Br J Haematol. 2014 Aug; 166(3):311-25.
Wang CC, Carnevale J, Rubenstein JL. PMID: 24837460; PMCID: PMC4107064.
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PubMed Mentions:
26 Fields:
Translation:
Humans
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SYK regulates mTOR signaling in AML. Leukemia. 2013 Nov; 27(11):2118-28.
Carnevale J, Ross L, Puissant A, Banerji V, Stone RM, DeAngelo DJ, Ross KN, Stegmaier K. PMID: 23535559; PMCID: PMC4028963.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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The crimson care collaborative: a student-faculty initiative to increase medical students' early exposure to primary care. Acad Med. 2012 May; 87(5):651-5.
Berman R, Powe C, Carnevale J, Chao A, Knudsen J, Nguyen A, Edgman-Levitan S. PMID: 22450186.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Knowledge base and caretaker-child communication about HIV in peri-urban schoolchildren of Lusaka, Zambia. AIDS Care. 2011 May; 23(5):646-53.
Carnevale J, Gropper AB, Agnew-Blais J, Mimiaga MJ, Mhango A, Bail R, Ngoma M. PMID: 21293994.
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PubMed Mentions:
3 Fields:
Translation:
HumansCells
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Schistosomiasis haematobium prevalence and risk factors in a school-age population of peri-urban Lusaka, Zambia. J Trop Pediatr. 2010 Aug; 56(4):247-53.
Agnew-Blais J, Carnevale J, Gropper A, Shilika E, Bail R, Ngoma M. PMID: 19892835.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimals
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The development of sentence interpretation: effects of perceptual, attentional and semantic interference. Dev Sci. 2007 Nov; 10(6):794-813.
Leech R, Aydelott J, Symons G, Carnevale J, Dick F. PMID: 17973797.
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PubMed Mentions:
7 Fields:
Translation:
Humans