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    Diana Laird, PhD

    Address35 Medical Center way
    San Fancisco CA 94143

      Our research focuses on the development of germ cells in mammalian embryos. We are working toward understanding the causes of infertility, enhancing our understanding of the fundamental process of gamete selection in evolution, and unlocking the potential of stem cells to generate gametes for research, human reproduction and agriculture.

      Developmental biology, reproductive biology, primordial germ cells, stem cells, cell competition, environmental health, environmental exposures, endocrine disruptors, transgenerational epigenetic inheritance

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       Global Health

      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Faire M, Skillern A, Arora R, Nguyen DH, Wang J, Chamberlain C, German MS, Fung JC, Laird DJ. Follicle dynamics and global organization in the intact mouse ovary. Dev Biol. 2015 Apr 16.
        View in: PubMed
      2. Arora R, Altman E, Tran ND, Laird DJ. Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system. Dev Dyn. 2014 Aug; 243(8):1037-45.
        View in: PubMed PMC4258601
      3. CantĂș AV, Laird DJ. Wnt and Bmp fit germ cells to a T. Dev Cell. 2013 Dec 9; 27(5):485-7.
        View in: PubMed PMC3929049
      4. Blaschke K, Ebata KT, Karimi MM, Zepeda-MartĂ­nez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 2013 Aug 8; 500(7461):222-6.
        View in: PubMed PMC3893718
      5. Laird DJ. Humans put their eggs in more than one basket. Nat Cell Biol. 2013 Jan; 15(1):13-5.
        View in: PubMed PMC3889477
      6. Chen L, Faire M, Kissner MD, Laird DJ. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet. 2013 Jan 15; 22(2):313-27.
        View in: PubMed PMC3526162
      7. Laird DJ, Altshuler-Keylin S, Kissner MD, Zhou X, Anderson KV. Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet. 2011 Dec; 7(12):e1002428.
        View in: PubMed PMC3245308
      8. Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest. 2010 Sep; 120(9):3120-6.
        View in: PubMed PMC2929736
      9. Laird DJ, von Andrian UH, Wagers AJ. Stem cell trafficking in tissue development, growth, and disease. Cell. 2008 Feb 22; 132(4):612-30.
        View in: PubMed
      10. Laird DJ, De Tomaso AW, Weissman IL. Stem cells are units of natural selection in a colonial ascidian. Cell. 2005 Dec 29; 123(7):1351-60.
        View in: PubMed
      11. Laird DJ, Chang WT, Weissman IL, Lauzon RJ. Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri. Dev Dyn. 2005 Dec; 234(4):997-1005.
        View in: PubMed PMC2821222
      12. Laird DJ, De Tomaso AW. Predatory stem cells in the non-zebrafish chordate, Botryllus schlosseri. Zebrafish. 2005; 1(4):357-61.
        View in: PubMed
      13. Laird DJ, Weissman IL. Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri. Dev Biol. 2004 Sep 15; 273(2):185-94.
        View in: PubMed
      14. Laird DJ, Weissman IL. Continuous development precludes radioprotection in a colonial ascidian. Dev Comp Immunol. 2004 Mar; 28(3):201-9.
        View in: PubMed
      15. Laird DJ, De Tomaso AW, Cooper MD, Weissman IL. 50 million years of chordate evolution: seeking the origins of adaptive immunity. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):6924-6.
        View in: PubMed PMC34360
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