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    Diana Laird, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentOb/Gyn, Reproductive Sciences
    Address35 Medical Center way
    San Francisco CA 94131
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      Collapse Biography 
      Collapse Education and Training
      Harvard UniversityA.B.Physics1995
      Stanford UniversityPh.D.Biological Sciences2003
      Sloan Kettering InstitutePostdoctoral FellowshipDevelopmental Biology2007

      Collapse Overview 
      Collapse Overview
      Our research focuses on the development of germ cells in mammalian embryos. We are working toward understanding the causes of infertility, enhancing our understanding of the fundamental process of gamete selection in evolution, and unlocking the potential of stem cells to generate gametes for research, human reproduction and agriculture.

      Collapse Interests
      Developmental biology, reproductive biology, primordial germ cells, stem cells, cell competition, environmental health, environmental exposures, endocrine disruptors, transgenerational epigenetic inheritance

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      Collapse In The News
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      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Arora R, Fries A, Oelerich K, Marchuk K, Sabeur K, Giudice LC, Laird DJ. Insights from imaging the implanting embryo and the uterine environment in three-dimensions. Development. 2016 Nov 11. PMID: 27836961.
        View in: PubMed
      2. Arora R, Laird DJ. ROR2 in the adult mouse testis. Mol Reprod Dev. 2016 Nov; 83(11):943. PMID: 27696582.
        View in: PubMed
      3. Cantú AV, Altshuler-Keylin S, Laird DJ, et al. Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling. J Cell Biol. 2016 Jul 18; 214(2):215-29. PMID: 27402951.
        View in: PubMed
      4. Arora R, Abby E, Ross AD, Cantu AV, Kissner MD, Castro V, Ho HY, Livera G, Laird DJ. Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary. J Cell Sci. 2016 Jul 1; 129(13):2493-9. PMID: 27199373.
        View in: PubMed
      5. Tran ND, Kissner M, Subramanyam D, Parchem RJ, Laird DJ, Blelloch RH. A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates. Stem Cells. 2016 Jul; 34(7):1985-91. PMID: 27066911.
        View in: PubMed
      6. Martins JP, Liu X, Oke A, Arora R, Franciosi F, Viville S, Laird DJ, Fung JC, Conti M. DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation. J Cell Sci. 2016 Mar 15; 129(6):1271-82. PMID: 26826184.
        View in: PubMed
      7. Chen JC, Hoffman JR, Arora R, Perrone LA, Gonzalez-Gomez CJ, Vo KC, Laird DJ, Irwin JC, Giudice LC. Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity. Fertil Steril. 2016 Feb; 105(2):501-510.e1. PMID: 26515378.
        View in: PubMed
      8. Faire M, Skillern A, Arora R, Nguyen DH, Wang J, Chamberlain C, German MS, Fung JC, Laird DJ. Follicle dynamics and global organization in the intact mouse ovary. Dev Biol. 2015 Jul 1; 403(1):69-79. PMID: 25889274; PMCID: PMC4469539 [Available on 07/01/16].
      9. Arora R, Altman E, Tran ND, Laird DJ. Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system. Dev Dyn. 2014 Aug; 243(8):1037-45. PMID: 24753105; PMCID: PMC4258601.
      10. Cantú AV, Laird DJ. Wnt and Bmp fit germ cells to a T. Dev Cell. 2013 Dec 9; 27(5):485-7. PMID: 24331924; PMCID: PMC3929049.
      11. Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 2013 Aug 8; 500(7461):222-6. PMID: 23812591; PMCID: PMC3893718.
      12. Laird DJ. Humans put their eggs in more than one basket. Nat Cell Biol. 2013 Jan; 15(1):13-5. PMID: 23263370; PMCID: PMC3889477.
      13. Chen L, Faire M, Kissner MD, Laird DJ. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet. 2013 Jan 15; 22(2):313-27. PMID: 23077213; PMCID: PMC3526162.
      14. Laird DJ, Altshuler-Keylin S, Kissner MD, Zhou X, Anderson KV. Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet. 2011 Dec; 7(12):e1002428. PMID: 22216013; PMCID: PMC3245308.
      15. Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest. 2010 Sep; 120(9):3120-6. PMID: 20739754; PMCID: PMC2929736.
      16. Laird DJ, von Andrian UH, Wagers AJ. Stem cell trafficking in tissue development, growth, and disease. Cell. 2008 Feb 22; 132(4):612-30. PMID: 18295579.
        View in: PubMed
      17. Laird DJ, De Tomaso AW, Weissman IL. Stem cells are units of natural selection in a colonial ascidian. Cell. 2005 Dec 29; 123(7):1351-60. PMID: 16377573.
        View in: PubMed
      18. Laird DJ, Chang WT, Weissman IL, Lauzon RJ. Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri. Dev Dyn. 2005 Dec; 234(4):997-1005. PMID: 16193502; PMCID: PMC2821222.
      19. Laird DJ, De Tomaso AW. Predatory stem cells in the non-zebrafish chordate, Botryllus schlosseri. Zebrafish. 2005; 1(4):357-61. PMID: 18248214.
        View in: PubMed
      20. Laird DJ, Weissman IL. Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri. Dev Biol. 2004 Sep 15; 273(2):185-94. PMID: 15328006.
        View in: PubMed
      21. Laird DJ, Weissman IL. Continuous development precludes radioprotection in a colonial ascidian. Dev Comp Immunol. 2004 Mar; 28(3):201-9. PMID: 14642887.
        View in: PubMed
      22. Laird DJ, De Tomaso AW, Cooper MD, Weissman IL. 50 million years of chordate evolution: seeking the origins of adaptive immunity. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):6924-6. PMID: 10860947; PMCID: PMC34360.
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