Matthew Springer, PhD

SchoolUCSF School of Medicine
Address513 Parnassus Avenue
San Francisco CA 94143
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    Dr. Matthew L. Springer received his BA from the University of California, Berkeley in 1985 and his PhD from Stanford University in 1992. He did postdoctoral research at Stanford and continued his research there as a senior scientist until joining the UCSF faculty in 2003, where he is currently one of two non-clinicians on the faculty of the Division of Cardiology. The close juxtaposition of his basic research background with the clinical cardiologists in the Division has resulted in an active translational research program.

    Dr. Springer's research interests include cell therapy and gene therapy approaches to studying cardiovascular disease, with the goals of exploring potential treatments and understanding underlying mechanisms involved in angiogenesis, vascular function, and treatments for myocardial infarction. The laboratory is studying the therapeutic effects of ultrasound-guided bone marrow cell implantation into the heart after myocardial infarction, with a special emphasis on the therapeutic implications of the age and cardiac disease state of the cell donor. Similarly, the lab is studying the effects of age and disease on circulating angiogenic cells (sometimes called endothelial progenitor cells), with a focus on the roles of endothelial nitric oxide synthase and nitric oxide in the function of these cells. The main angiogenesis interest is how cardiac motion and cyclical forces influences angiogenic gene expression and cell behavior. Currently, a large effort involves the study of vascular reactivity using a rat model of endothelium-dependent flow-mediated vasodilation that they developed, and how vascular endothelial function is affected by exposure to secondhand smoke from tobacco and marijuana.

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    Inhibition of Galectin-3 for Therapy of Remodeling After Myocardial Infarction
    NIH/NIA R44AG054386Aug 15, 2016 - Mar 31, 2019
    Role: Co-Principal Investigator
    Measuring relative cardiovascular health risks of inhaled tobacco products
    NIH/NHLBI R01HL120062Jun 1, 2014 - May 31, 2019
    Role: Principal Investigator
    Protein inhibitor of galectin-3 to limit fibrosis after myocardial infarction
    NIH/NHLBI R43HL120645Sep 4, 2013 - Aug 31, 2014
    Role: Co-Principal Investigator
    Evaluation of harmful effects of cannabis smoke on vascular endothelial function
    NIH/NIDA R21DA031966Sep 15, 2011 - Jun 30, 2014
    Role: Principal Investigator
    Bone marrow cell therapy for cardiac disease: Impact of donor age and infarction
    NIH/NHLBI R21HL097129Jul 1, 2010 - Jun 30, 2012
    Role: Principal Investigator
    The Role of Nitric Oxide Synthase in Circulating Progenitor Cell Function
    NIH/NHLBI R01HL086917Aug 1, 2007 - Jun 30, 2013
    Role: Principal Investigator
    Closed-Chest Cell Injections into Mouse Myocardium Targeted by Ultrasound
    NIH/NIBIB R03EB005802Sep 15, 2005 - Aug 31, 2007
    Role: Principal Investigator
    NIH/NHLBI F32HL008991Mar 26, 1994
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wang X, Derakhshandeh R, Liu J, Narayan S, Nabavizadeh P, Le S, Danforth OM, Pinnamaneni K, Rodriguez HJ, Luu E, Sievers RE, Schick SF, Glantz SA, Springer ML. One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function. J Am Heart Assoc. 2016 Jul 27; 5(8). PMID: 27464788.
      View in: PubMed
    2. Springer M . San Francisco Medicine. CANNABIS: Clearing some smoke?. 2016; 2(89):26.
    3. Aschbacher K, Derakhshandeh R, Flores AJ, Narayan S, Mendes WB, Springer M. Circulating angiogenic cell function is inhibited by cortisol in vitro and associated with psychological stress and cortisol in vivo. Psychoneuroendocrinology. 2016 May; 67:216-23. PMID: 26925833; PMCID: PMC4808379 [Available on 05/01/17].
    4. Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML. Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction. J Am Heart Assoc. 2016 Jan 06; 5(1). PMID: 26738788; PMCID: PMC4859354.
    5. Liu J, Wang X, Narayan S, Glantz SA, Schick SF, Springer M, et al. Impairment of Endothelial Function by Little Cigar Secondhand Smoke. Tob Regul Sci. 2016 Jan 01; 2(1):56-63. PMID: 26753171.
      View in: PubMed
    6. Rafikov R, Kumar S, Aggarwal S, Pardo D, Fonseca FV, Ransom J, Rafikova O, Chen Q, Springer M, Black SM. Protein engineering to develop a redox insensitive endothelial nitric oxide synthase. Redox Biol. 2014; 2C:156-164.
    7. Pinnamaneni K, Sievers RE, Sharma R, Selchau AM, Gutierrez G, Nordsieck EJ, Su R, An S, Chen Q, Wang X, Derakhshandeh R, Aschbacher K, Heiss C, Glantz SA, Schick SF, Springer ML. Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function. Nicotine Tob Res. 2014 May; 16(5):584-90. PMID: 24302638; PMCID: PMC3977486.
    8. Horn P, Amabile N, Angeli FS, Sansone R, Stegemann B, Kelm M, Springer ML, Yeghiazarians Y, Schroeter H, Heiss C. Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients. Br J Nutr. 2014 Apr 14; 111(7):1245-52. PMID: 24286443.
      View in: PubMed
    9. Fang Q, Mok PY, Thomas AE, Haddad DJ, Saini SA, Clifford BT, Kapasi NK, Danforth OM, Usui M, Ye W, Luu E, Sharma R, Bartel MJ, Pathmanabhan JA, Ang AA, Sievers RE, Lee RJ, Springer ML. Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants. PLoS One. 2013; 8(4):e61413. PMID: 23630585; PMCID: PMC3632611.
    10. Chen Q, Sievers RE, Varga M, Kharait S, Haddad DJ, Patton AK, Delany CS, Mutka SC, Blonder JP, Dubé GP, Rosenthal GJ, Springer ML. Pharmacological inhibition of S-nitrosoglutathione reductase improves endothelial vasodilatory function in rats in vivo. J Appl Physiol (1985). 2013 Mar 15; 114(6):752-60. PMID: 23349456; PMCID: PMC3615603.
    11. Springer M . Earthquake safety at work: An important topic to review with patients. San Francisco Medicine. 2012; 85(9):12-13.
    12. Lin YD, Luo CY, Hu YN, Yeh ML, Hsueh YC, Chang MY, Tsai DC, Wang JN, Tang MJ, Wei EI, Springer ML, Hsieh PC. Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair. Sci Transl Med. 2012 Aug 08; 4(146):146ra109. PMID: 22875829.
      View in: PubMed
    13. Springer M . Gene therapy and angiogenesis. Cardiology: An Illustrated Textbook. K. Chatterjee et al., eds. 2012; 2013-2029.
    14. Wang X, Takagawa J, Haddad DJ, Pinnamaneni K, Zhang Y, Sievers RE, Grossman W, Yeghiazarians Y, Springer ML. Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. J Tissue Sci Eng. 2011 Nov 18; S3. PMID: 22675670.
      View in: PubMed
    15. Springer ML, Wang X. Blunting half of the double-edged sword: potential use of interleukin-10 to protect bone marrow-derived cells after myocardial infarction. Circ Res. 2011 Nov 11; 109(11):1196-8. PMID: 22076503.
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    16. Aschbacher K, Chen Q, Varga M, Haddad DJ, Yeghiazarians Y, Epel E, Wolkowitz OM, Springer ML. Higher fasting glucose levels are associated with reduced circulating angiogenic cell migratory capacity among healthy individuals. Am J Cardiovasc Dis. 2012; 2(1):12-9. PMID: 22254209; PMCID: PMC3257152.
    17. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML. Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Sci Transl Med. 2011 Sep 14; 3(100):100ra90. PMID: 21918107; PMCID: PMC3350804.
    18. Kharait S, Haddad DJ, Springer ML. Nitric oxide counters the inhibitory effects of uremic toxin indoxyl sulfate on endothelial cells by governing ERK MAP kinase and myosin light chain activation. Biochem Biophys Res Commun. 2011 Jun 17; 409(4):758-63. PMID: 21621512; PMCID: PMC3121259.
    19. Roberts WC, Springer M, Wang X, Wang D. The launch of American Journal of Cardiovascular Disease. Am J Cardiovasc Dis. 2011; 1:i-ii.
    20. Zhang Y, Sievers RE, Prasad M, Mirsky R, Shih H, Wong ML, Angeli FS, Ye J, Takagawa J, Koskenvuo JW, Springer M, Grossman W, Boyle AJ, Yeghiazarians Y. Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Cardiovasc Pathol. 2011; 20:204-212.
    21. Heiss C, Schanz A, Amabile N, Jahn S, Chen Q, Wong ML, Rassaf T, Heinen Y, Cortese-Krott M, Grossman W, Yeghiazarians Y, Springer ML. Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2212-8. PMID: 20705916; PMCID: PMC2959135.
    22. Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. J Am Coll Cardiol. 2010 Jul 13; 56(3):218-24. PMID: 20620742.
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    23. Springer ML. Assessment of myocardial angiogenesis and vascularity in small animal models. Methods Mol Biol. 2010; 660:149-67. PMID: 20680818.
      View in: PubMed
    24. Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Mol Ther. 2009 Jul; 17(7):1250-6. PMID: 19384293; PMCID: PMC2835212.
    25. Li X, Tjwa M, Van Hove I, Enholm B, Neven E, Paavonen K, Jeltsch M, Juan TD, Sievers RE, Chorianopoulos E, Wada H, Vanwildemeersch M, Noel A, Foidart JM, Springer ML, von Degenfeld G, Dewerchin M, Blau HM, Alitalo K, Eriksson U, Carmeliet P, Moons L. Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium. Arterioscler Thromb Vasc Biol. 2008 Sep; 28(9):1614-20. PMID: 18511699; PMCID: PMC2753879.
    26. Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol. 2008 May 06; 51(18):1760-71. PMID: 18452782.
      View in: PubMed
    27. Heiss C, Wong ML, Block VI, Lao D, Real WM, Yeghiazarians Y, Lee RJ, Springer ML. Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells. J Cell Physiol. 2008 May; 215(2):366-73. PMID: 17960557; PMCID: PMC2697332.
    28. Springer M . Living both music and medicine: Where the two practices intersect. (One of several sections.). San Francisco Medicine. 2008; 81(2):38-39.
    29. Heiss C, Sievers RE, Amabile N, Momma TY, Chen Q, Natarajan S, Yeghiazarians Y, Springer ML. In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H1086-93. PMID: 18055528.
      View in: PubMed
    30. Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. J Appl Physiol (1985). 2007 Jun; 102(6):2104-11. PMID: 17347379; PMCID: PMC2675697.
    31. Springer ML, Banfi A, Ye J, von Degenfeld G, Kraft PE, Saini SA, Kapasi NK, Blau HM. Localization of vascular response to VEGF is not dependent on heparin binding. FASEB J. 2007 Jul; 21(9):2074-85. PMID: 17325231.
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    32. Zhang Y, Takagawa J, Sievers RE, Khan MF, Viswanathan MN, Springer ML, Foster E, Yeghiazarians Y. Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb; 292(2):H1187-92. PMID: 17028161.
      View in: PubMed
    33. Springer ML. A balancing act: therapeutic approaches for the modulation of angiogenesis. Curr Opin Investig Drugs. 2006 Mar; 7(3):243-50. PMID: 16555684.
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    34. von Degenfeld G, Banfi A, Springer M, Wagner RA, Jacobi J, Ozawa CR, Merchant MJ, Cooke JP, Blau HM. Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia. FASEBJ. 2006; 20(14):2657-9.
    35. Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald DM. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H560-76. PMID: 16172168.
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    36. Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y. Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1307-14. PMID: 15908468.
      View in: PubMed
    37. Ozawa CR, Banfi A, Glazer NL, Thurston G, Springer ML, Kraft PE, McDonald DM, Blau HM. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest. 2004 Feb; 113(4):516-27. PMID: 14966561; PMCID: PMC338257.
    38. von Degenfeld G, Banfi A, Springer ML, Blau HM. Myoblast-mediated gene transfer for therapeutic angiogenesis and arteriogenesis. Br J Pharmacol. 2003 Oct; 140(4):620-6. PMID: 14534145; PMCID: PMC1574078.
    39. Springer ML, Ozawa CR, Banfi A, Kraft PE, Ip TK, Brazelton TR, Blau HM. Localized arteriole formation directly adjacent to the site of VEGF-induced angiogenesis in muscle. Mol Ther. 2003 Apr; 7(4):441-9. PMID: 12727106.
      View in: PubMed
    40. Munz B, Hildt E, Springer ML, Blau HM. RIP2, a checkpoint in myogenic differentiation. Mol Cell Biol. 2002 Aug; 22(16):5879-86. PMID: 12138198; PMCID: PMC133983.
    41. Springer ML, Ozawa CR, Blau HM. Transient production of alpha-smooth muscle actin by skeletal myoblasts during differentiation in culture and following intramuscular implantation. Cell Motil Cytoskeleton. 2002 Apr; 51(4):177-86. PMID: 11977092.
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    42. Springer ML. VEGF therapy in heart disease: for better or for worse? Drug Discov Today. 2002 Feb 15; 7(4):209-11. PMID: 11839510.
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    43. Springer ML, Rando TA, Blau HM. Gene delivery to muscle. Curr Protoc Hum Genet. 2002 Feb; Chapter 13:Unit13.4. PMID: 18428326.
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    44. Banfi A, Springer ML, Blau HM. Myoblast-mediated gene transfer for therapeutic angiogenesis. Methods Enzymol. 2002; 346:145-57. PMID: 11883066.
      View in: PubMed
    45. Springer ML, Brazelton TR, Blau HM. Not the usual suspects: the unexpected sources of tissue regeneration. J Clin Invest. 2001 Jun; 107(11):1355-6. PMID: 11390416; PMCID: PMC209330.
    46. Lee RJ, Springer ML, Blanco-Bose WE, Shaw R, Ursell PC, Blau HM. VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation. 2000 Aug 22; 102(8):898-901. PMID: 10952959.
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    47. Springer ML, Hortelano G, Bouley DM, Wong J, Kraft PE, Blau HM. Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor. J Gene Med. 2000 Jul-Aug; 2(4):279-88. PMID: 10953919.
      View in: PubMed
    48. Ozawa CR, Springer ML, Blau HM. A novel means of drug delivery: myoblast-mediated gene therapy and regulatable retroviral vectors. Annu Rev Pharmacol Toxicol. 2000; 40:295-317. PMID: 10836138.
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    49. Springer ML, Ip TK, Blau HM. Angiogenesis monitored by perfusion with a space-filling microbead suspension. Mol Ther. 2000 Jan; 1(1):82-7. PMID: 10933915.
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    50. Ozawa CR, Springer M, Blau HM. Ex vivo gene therapy using myoblasts and regulatable retroviral vectors. In Gene Therapy: Therapeutic Mechanisms and Strategies, NS Templeton and DD Lasic, eds. 2000; 61-80.
    51. Abendroth A, Slobedman B, Springer ML, Blau HM, Arvin AM. Analysis of immune responses to varicella zoster viral proteins induced by DNA vaccination. Antiviral Res. 1999 Dec 31; 44(3):179-92. PMID: 10651069.
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    52. Springer ML, Chen AS, Kraft PE, Bednarski M, Blau HM. VEGF gene delivery to muscle: potential role for vasculogenesis in adults. Mol Cell. 1998 Nov; 2(5):549-58. PMID: 9844628.
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    53. Springer ML, Kraft PE, Blau HM. Inhibition of solid tumor growth by Fas ligand-expressing myoblasts. Somat Cell Mol Genet. 1998 Sep; 24(5):281-9. PMID: 10696236.
      View in: PubMed
    54. Kang SM, Hoffmann A, Le D, Springer ML, Stock PG, Blau HM. Immune response and myoblasts that express Fas ligand. Science. 1997 Nov 14; 278(5341):1322-4. PMID: 9411754.
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    55. Springer ML, Blau HM. High-efficiency retroviral infection of primary myoblasts. Somat Cell Mol Genet. 1997 May; 23(3):203-9. PMID: 9330631.
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    56. Springer, ML. Towards a treatment for Tay-Sachs disease. Molec. Med. Today. 1996; 2:232.
    57. Blau HM, Springer ML. Muscle-mediated gene therapy. N Engl J Med. 1995 Dec 07; 333(23):1554-6. PMID: 7477172.
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    58. Blau HM, Springer ML. Gene therapy--a novel form of drug delivery. N Engl J Med. 1995 Nov 02; 333(18):1204-7. PMID: 7565977.
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    59. Springer, ML. Cell implantation treatment for MPS VII. Molec. Med. Today. 1995; 1:111.
    60. Springer, ML. Gene therapy for restenosis: retinoblastoma to the rescue. Molec. Med. Today. 1995; 1:57.
    61. Springer ML, Patterson B, Spudich JA. Stage-specific requirement for myosin II during Dictyostelium development. Development. 1994 Sep; 120(9):2651-60. PMID: 7956839.
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    62. Springer ML. Genetic control of fungal differentiation: the three sporulation pathways of Neurospora crassa. Bioessays. 1993 Jun; 15(6):365-74. PMID: 8357339.
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    63. Springer M, Hager KM, Garrett-Engele C, Yanofsky C. Timing of synthesis and cellular localization of two conidiation-specific proteins of Neurospora crassa. Dev Biol. 1992 Aug; 152(2):255-62. PMID: 1386581.
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    64. Springer M, Yanofsky C. Expression of con genes along the three sporulation pathways of Neurospora crassa. Genes Dev. 1992 Jun; 6(6):1052-7. PMID: 1534304.
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    65. Springer, ML. Tergitol-induced colonial growth without inhibition of conidiation. Fungal Genet. Newsl. 1991; 38:92.
    66. Springer M, Yanofsky C. A morphological and genetic analysis of conidiophore development in Neurospora crassa. Genes Dev. 1989 Apr; 3(4):559-71. PMID: 2524423.
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    67. Springer, ML. An effective procedure for the preparation of Neurospora crassa conidiophores for scanning electron microscopy. Fungal Genet. Newsl. 1989; 36:78.
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