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    Norbert Schuff, PhD

    TitleAdjunct Professor
    SchoolUCSF School of Medicine
    DepartmentRadiology
    Address4150 Clement St
    San Francisco CA 94121
    Phone415-221-4810
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of Heidelberg, GermanyDoctor of Natural Sciences (Dr. rer. nat.)Physics and Astronomy1983
      University of California, San FranciscoPostdoctoral StudiesGraduate Division1993
      Collapse Awards and Honors
      Johann Wolfgang Goethe University Frankfurt2002 - 2003Friedrich Merz Foundation Guest-Professorship
      Alzheimer Association1998Individual Research Project Award

      Collapse Overview 
      Collapse Overview
      I am a Professor in the Department of Radiology and Biomedical Imaging at the University of California, San Francisco. I earned my PhD in Physics from the Ruprecht Karls University of Heidelberg/Germany in 1983. From 1984 to 1992, I developed MRI systems first with Bruker GmbH in Karlsruhe/Germany and later with Varian Associates in Palo Alto, California. In 1993, I joined UCSF.

      I study brain diseases such as Alzheimer's and Parkinson's using imaging. My main interest is to improve diagnosis and assess potential treatments. I accomplish this by developing novel computational methods for analyzing brain images using MRI physics as well as modern concepts of probability theory and statistical learning.

      Expertise:
      Neuroimaging

      Specialty:
      Neurodegenerative diseases

      Professional Interests:
      MRI, statistical learning, information theory, brain aging, Alzheimer's disease, Parkinson's disease

      Education and Training:
      • Bachelor of Science: University of Heidelberg, Germany - Physics and Astronomy
      • Masters of Science: University of Heidelberg, Germany - Physics and Astronomy
      • Doctor of Physics: University of Heidelberg, Germany - Physics
      • Research Assistant: Max Planck Institute for Medical Research, Germany
      • Postdoctoral Fellowship: University of California, San Francisco - Radiology

      Collapse Interests
      Neuroimaging, MRI, statistical learning, information theory, cerebral blood flow, brain aging, Alzheimer's and Parkinson's disease.

      Collapse ORNG Applications 
      Collapse Websites
      Collapse In The News
      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Zhang Y, Wu IW, Tosun D, Foster E, Schuff N. Progression of Regional Microstructural Degeneration in Parkinson's Disease: A Multicenter Diffusion Tensor Imaging Study. PLoS One. 2016; 11(10):e0165540. PMID: 27798653.
        View in: PubMed
      2. Dutt S, Binney RJ, Heuer HW, Luong P, Attygalle S, Bhatt P, Marx GA, Elofson J, Tartaglia MC, Litvan I, McGinnis SM, Dickerson BC, Kornak J, Waltzman D, Voltarelli L, Schuff N, Rabinovici GD, Kramer JH, Jack CR, Miller BL, Rosen HJ, Boxer AL. Progression of brain atrophy in PSP and CBS over 6 months and 1 year. Neurology. 2016 Oct 14. PMID: 27742814.
        View in: PubMed
      3. Tosun D, Schuff N, Rabinovici GD, Ayakta N, Miller BL, Jagust W, Kramer J, Weiner MM, Rosen HJ. Diagnostic utility of ASL-MRI and FDG-PET in the behavioral variant of FTD and AD. Ann Clin Transl Neurol. 2016 Oct; 3(10):740-751. PMID: 27752510.
        View in: PubMed
      4. Zhang Y, Walter R, Ng P, Luong PN, Dutt S, Heuer H, Rojas-Rodriguez JC, Tsai R, Litvan I, Dickerson BC, Tartaglia MC, Rabinovici G, Miller BL, Rosen HJ, Schuff N, Boxer AL. Progression of Microstructural Degeneration in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Longitudinal Diffusion Tensor Imaging Study. PLoS One. 2016; 11(6):e0157218. PMID: 27310132.
        View in: PubMed
      5. Tosun D, Schuff N, Jagust W, Weiner MW. Discriminative Power of Arterial Spin Labeling Magnetic Resonance Imaging and 18F-Fluorodeoxyglucose Positron Emission Tomography Changes for Amyloid-ß-Positive Subjects in the Alzheimer's Disease Continuum. Neurodegener Dis. 2016; 16(1-2):87-94. PMID: 26560336.
        View in: PubMed
      6. Teipel S, Drzezga A, Grothe MJ, Barthel H, Chételat G, Schuff N, Skudlarski P, Cavedo E, Frisoni GB, Hoffmann W, Thyrian JR, Fox C, Minoshima S, Sabri O, Fellgiebel A. Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection. Lancet Neurol. 2015 Oct; 14(10):1037-53. PMID: 26318837.
        View in: PubMed
      7. Pankov A, Binney RJ, Staffaroni AM, Kornak J, Attygalle S, Schuff N, Weiner MW, Kramer JH, Dickerson BC, Miller BL, Rosen HJ. Data-driven regions of interest for longitudinal change in frontotemporal lobar degeneration. Neuroimage Clin. 2016; 12:332-40. PMID: 27547726.
        View in: PubMed
      8. Schuff N, Wu IW, Buckley S, Foster ED, Coffey CS, Gitelman DR, Mendick S, Seibyl J, Simuni T, Zhang Y, Jankovic J, Hunter C, Tanner CM, Rees L, Factor S, Berg D, Wurster I, Gauss K, Sprenger F, Seppi K, Poewe W, Mollenhauer B, Knake S, Mari Z, McCoy A, Ranola M, Marek K. Diffusion imaging of nigral alterations in early Parkinson's disease with dopaminergic deficits. Mov Disord. 2015 Dec; 30(14):1885-92. PMID: 26260437.
        View in: PubMed
      9. Jack CR, Barnes J, Bernstein MA, Borowski BJ, Brewer J, Clegg S, Dale AM, Carmichael O, Ching C, DeCarli C, Desikan RS, Fennema-Notestine C, Fjell AM, Fletcher E, Fox NC, Gunter J, Gutman BA, Holland D, Hua X, Insel P, Kantarci K, Killiany RJ, Krueger G, Leung KK, Mackin S, Maillard P, Malone IB, Mattsson N, McEvoy L, Modat M, Mueller S, Nosheny R, Ourselin S, Schuff N, Senjem ML, Simonson A, Thompson PM, Rettmann D, Vemuri P, Walhovd K, Zhao Y, Zuk S, Weiner M. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2. Alzheimers Dement. 2015 Jul; 11(7):740-56. PMID: 26194310; PMCID: PMC4523217 [Available on 07/01/16].
      10. Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang Z, Sears R, Klein E, Wojta K, Rosen HJ. Amyloid in dementia associated with familial FTLD: not an innocent bystander. Neurocase. 2016 Feb; 22(1):76-83. PMID: 26040468; PMCID: PMC4662906 [Available on 02/01/17].
      11. Zhang Y, Wu IW, Buckley S, Coffey CS, Foster E, Mendick S, Seibyl J, Schuff N. Diffusion tensor imaging of the nigrostriatal fibers in Parkinson's disease. Mov Disord. 2015 Aug; 30(9):1229-36. PMID: 25920732; PMCID: PMC4418199 [Available on 08/01/16].
      12. Friedman EJ, Young K, Tremper G, Liang J, Landsberg AS, Schuff N. Directed network motifs in Alzheimer's disease and mild cognitive impairment. PLoS One. 2015; 10(4):e0124453. PMID: 25879535; PMCID: PMC4400037.
      13. Iglesias JE, Van Leemput K, Bhatt P, Casillas C, Dutt S, Schuff N, Truran-Sacrey D, Boxer A, Fischl B. Bayesian segmentation of brainstem structures in MRI. Neuroimage. 2015 Jun; 113:184-95. PMID: 25776214; PMCID: PMC4434226 [Available on 06/01/16].
      14. Pannetier NA, Stavrinos T, Ng P, Herbst M, Zaitsev M, Young K, Matson G, Schuff N. Quantitative framework for prospective motion correction evaluation. Magn Reson Med. 2016 Feb; 75(2):810-6. PMID: 25761550.
        View in: PubMed
      15. Lam F, Liu D, Song Z, Schuff N, Liang ZP. A fast algorithm for denoising magnitude diffusion-weighted images with rank and edge constraints. Magn Reson Med. 2016 Jan; 75(1):433-40. PMID: 25733066.
        View in: PubMed
      16. Bott NT, Johnson ET, Schuff N, Galifianakis N, Subas T, Pollock J, Pressman P, Kramer JH, Possin KL. Sensitive measures of executive dysfunction in non-demented Parkinson's disease. Parkinsonism Relat Disord. 2014 Dec; 20(12):1430-3. PMID: 25454318; PMCID: PMC4314390 [Available on 12/01/15].
      17. Nosheny RL, Insel PS, Truran D, Schuff N, Jack CR, Aisen PS, Shaw LM, Trojanowski JQ, Weiner MW. Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment. Neurobiol Aging. 2015 Jan; 36(1):273-82. PMID: 25175807.
        View in: PubMed
      18. Friedman EJ, Young K, Asif D, Jutla I, Liang M, Wilson S, Landsberg AS, Schuff N. Directed progression brain networks in Alzheimer's disease: properties and classification. Brain Connect. 2014 Jun; 4(5):384-93. PMID: 24901258; PMCID: PMC4064803.
      19. Mattsson N, Tosun D, Insel PS, Simonson A, Jack CR, Beckett LA, Donohue M, Jagust W, Schuff N, Weiner MW. Association of brain amyloid-ß with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment. Brain. 2014 May; 137(Pt 5):1550-61. PMID: 24625697; PMCID: PMC3999717.
      20. Lam F, Babacan SD, Haldar JP, Weiner MW, Schuff N, Liang ZP. Denoising diffusion-weighted magnitude MR images using rank and edge constraints. Magn Reson Med. 2014 Mar; 71(3):1272-84. PMID: 23568755; PMCID: PMC3796128.
      21. Christen T, Pannetier NA, Ni WW, Qiu D, Moseley ME, Schuff N, Zaharchuk G. MR vascular fingerprinting: A new approach to compute cerebral blood volume, mean vessel radius, and oxygenation maps in the human brain. Neuroimage. 2014 Apr 1; 89:262-70. PMID: 24321559; PMCID: PMC3940168.
      22. Ewers M, Brendel M, Rizk-Jackson A, Rominger A, Bartenstein P, Schuff N, Weiner MW. Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects. Neuroimage Clin. 2014; 4:45-52. PMID: 24286024; PMCID: PMC3841292.
      23. Pannetier NA, Sohlin M, Christen T, Schad L, Schuff N. Numerical modeling of susceptibility-related MR signal dephasing with vessel size measurement: phantom validation at 3T. Magn Reson Med. 2014 Sep; 72(3):646-58. PMID: 24167116; PMCID: PMC3999331.
      24. Liu X, Tosun D, Weiner MW, Schuff N. Locally linear embedding (LLE) for MRI based Alzheimer's disease classification. Neuroimage. 2013 Dec; 83:148-57. PMID: 23792982; PMCID: PMC3815961.
      25. Zhang Y, Schuff N, Camacho M, Chao LL, Fletcher TP, Yaffe K, Woolley SC, Madison C, Rosen HJ, Miller BL, Weiner MW. MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements. PLoS One. 2013; 8(6):e66367. PMID: 23762488; PMCID: PMC3675142.
      26. Protas HD, Chen K, Langbaum JB, Fleisher AS, Alexander GE, Lee W, Bandy D, de Leon MJ, Mosconi L, Buckley S, Truran-Sacrey D, Schuff N, Weiner MW, Caselli RJ, Reiman EM. Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease. JAMA Neurol. 2013 Mar 1; 70(3):320-5. PMID: 23599929; PMCID: PMC3745014.
      27. Cardenas VA, Tosun D, Chao LL, Fletcher PT, Joshi S, Weiner MW, Schuff N. Voxel-wise co-analysis of macro- and microstructural brain alteration in mild cognitive impairment and Alzheimer's disease using anatomical and diffusion MRI. J Neuroimaging. 2014 Sep-Oct; 24(5):435-43. PMID: 23421601; PMCID: PMC3951683.
      28. Naylor MG, Cardenas VA, Tosun D, Schuff N, Weiner M, Schwartzman A. Voxelwise multivariate analysis of multimodality magnetic resonance imaging. Hum Brain Mapp. 2014 Mar; 35(3):831-46. PMID: 23408378; PMCID: PMC4324330.
      29. Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW. Patterns of reduced cortical thickness in late-life depression and relationship to psychotherapeutic response. Am J Geriatr Psychiatry. 2013 Aug; 21(8):794-802. PMID: 23567394; PMCID: PMC3732520.
      30. Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW. The effect of subsyndromal symptoms of depression and white matter lesions on disability for individuals with mild cognitive impairment. Am J Geriatr Psychiatry. 2013 Sep; 21(9):906-14. PMID: 23567388.
        View in: PubMed
      31. Zhang Y, Tartaglia MC, Schuff N, Chiang GC, Ching C, Rosen HJ, Gorno-Tempini ML, Miller BL, Weiner MW. MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes. J Alzheimers Dis. 2013; 33(2):431-44. PMID: 22976075; PMCID: PMC3738303.
      32. Wyman BT, Harvey DJ, Crawford K, Bernstein MA, Carmichael O, Cole PE, Crane PK, DeCarli C, Fox NC, Gunter JL, Hill D, Killiany RJ, Pachai C, Schwarz AJ, Schuff N, Senjem ML, Suhy J, Thompson PM, Weiner M, Jack CR. Standardization of analysis sets for reporting results from ADNI MRI data. Alzheimers Dement. 2013 May; 9(3):332-7. PMID: 23110865; PMCID: PMC3891834.
      33. Gregori J, Schuff N, Kern R, Günther M. T2-based arterial spin labeling measurements of blood to tissue water transfer in human brain. J Magn Reson Imaging. 2013 Feb; 37(2):332-42. PMID: 23019041; PMCID: PMC3554863.
      34. Mackin RS, Insel P, Tosun D, Mueller SG, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Lee JY, Jack CR, Aisen PS, Petersen RC, Weiner MW. The Effect of Subsyndromal Symptoms of Depression and White Matter Lesions on Disability for Individuals With Mild Cognitive Impairment. Am J Geriatr Psychiatry. 2012 Sep 26. PMID: 23018473.
        View in: PubMed
      35. Lee JY, Insel P, Mackin RS, Schuff N, Chui H, DeCarli C, Park KH, Mueller SG, Weiner MW. Different associations of white matter lesions with depression and cognition. BMC Neurol. 2012; 12:83. PMID: 22920586; PMCID: PMC3482604.
      36. Mackin RS, Tosun D, Mueller SG, Lee JY, Insel P, Schuff N, Truran-Sacrey D, Arean P, Nelson JC, Weiner MW. Patterns of Reduced Cortical Thickness in Late-Life Depression and Relationship to Psychotherapeutic Response. Am J Geriatr Psychiatry. 2012 Aug 17. PMID: 22902859.
        View in: PubMed
      37. Haldar JP, Wedeen VJ, Nezamzadeh M, Dai G, Weiner MW, Schuff N, Liang ZP. Improved diffusion imaging through SNR-enhancing joint reconstruction. Magn Reson Med. 2013 Jan; 69(1):277-89. PMID: 22392528; PMCID: PMC3407310.
      38. Chiang GC, Zhan W, Schuff N, Weiner MW. White matter alterations in cognitively normal apoE e2 carriers: insight into Alzheimer resistance? AJNR Am J Neuroradiol. 2012 Aug; 33(7):1392-7. PMID: 22383234; PMCID: PMC3951461.
      39. Liu Y, Zhu X, Feinberg D, Guenther M, Gregori J, Weiner MW, Schuff N. Arterial spin labeling MRI study of age and gender effects on brain perfusion hemodynamics. Magn Reson Med. 2012 Sep; 68(3):912-22. PMID: 22139957.
        View in: PubMed
      40. Ewers M, Insel P, Jagust WJ, Shaw L, Trojanowski JQ, Aisen P, Petersen RC, Schuff N, Weiner MW. CSF biomarker and PIB-PET-derived beta-amyloid signature predicts metabolic, gray matter, and cognitive changes in nondemented subjects. Cereb Cortex. 2012 Sep; 22(9):1993-2004. PMID: 22038908; PMCID: PMC3500862.
      41. Tosun D, Rosen H, Miller BL, Weiner MW, Schuff N. MRI patterns of atrophy and hypoperfusion associations across brain regions in frontotemporal dementia. Neuroimage. 2012 Feb 1; 59(3):2098-109. PMID: 22036676; PMCID: PMC3254855.
      42. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Thompson PM, Reiman EM, Jack CR, Fox NC, Jagust WJ, Harvey DJ, Beckett LA, Gamst A, Aisen PS, Petersen RC, Weiner MW. Impact of apolipoprotein E4-cerebrospinal fluid ß-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment. Alzheimers Dement. 2011 Sep; 7(5):514-20. PMID: 21889115; PMCID: PMC3177162.
      43. Zhan W, Kang GA, Glass GA, Zhang Y, Shirley C, Millin R, Possin KL, Nezamzadeh M, Weiner MW, Marks WJ, Schuff N. Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging. Mov Disord. 2012 Jan; 27(1):90-7. PMID: 21850668; PMCID: PMC4472452.
      44. Zhang Y, Schuff N, Woolley SC, Chiang GC, Boreta L, Laxamana J, Katz JS, Weiner MW. Progression of white matter degeneration in amyotrophic lateral sclerosis: A diffusion tensor imaging study. Amyotroph Lateral Scler. 2011 Nov; 12(6):421-9. PMID: 21745124; PMCID: PMC3804304.
      45. Zhang Y, Schuff N, Ching C, Tosun D, Zhan W, Nezamzadeh M, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW. Joint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia. Int J Alzheimers Dis. 2011; 2011:546871. PMID: 21760989; PMCID: PMC3132541.
      46. Cardenas VA, Samuelson K, Lenoci M, Studholme C, Neylan TC, Marmar CR, Schuff N, Weiner MW. Changes in brain anatomy during the course of posttraumatic stress disorder. Psychiatry Res. 2011 Aug 30; 193(2):93-100. PMID: 21683556; PMCID: PMC3175765.
      47. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang S, Jack CR, Weiner MW. Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes. Radiology. 2011 Jun; 259(3):844-51. PMID: 21467255; PMCID: PMC3099048.
      48. Tosun D, Schuff N, Mathis CA, Jagust W, Weiner MW. Spatial patterns of brain amyloid-beta burden and atrophy rate associations in mild cognitive impairment. Brain. 2011 Apr; 134(Pt 4):1077-88. PMID: 21429865; PMCID: PMC3069703.
      49. Hua X, Gutman B, Boyle CP, Rajagopalan P, Leow AD, Yanovsky I, Kumar AR, Toga AW, Jack CR, Schuff N, Alexander GE, Chen K, Reiman EM, Weiner MW, Thompson PM. Accurate measurement of brain changes in longitudinal MRI scans using tensor-based morphometry. Neuroimage. 2011 Jul 1; 57(1):5-14. PMID: 21320612; PMCID: PMC3394184.
      50. Jahng GH, Xu S, Weiner MW, Meyerhoff DJ, Park S, Schuff N. DTI studies in patients with Alzheimer's disease, mild cognitive impairment, or normal cognition with evaluation of the intrinsic background gradients. Neuroradiology. 2011 Oct; 53(10):749-62. PMID: 21340578; PMCID: PMC3184226.
      51. Ashford JW, Salehi A, Furst A, Bayley P, Frisoni GB, Jack CR, Sabri O, Adamson MM, Coburn KL, Olichney J, Schuff N, Spielman D, Edland SD, Black S, Rosen A, Kennedy D, Weiner M, Perry G. Imaging the Alzheimer brain. J Alzheimers Dis. 2011; 26 Suppl 3:1-27. PMID: 21971448; PMCID: PMC3760773.
      52. Woolley SC, Zhang Y, Schuff N, Weiner MW, Katz JS. Neuroanatomical correlates of apathy in ALS using 4 Tesla diffusion tensor MRI. Amyotroph Lateral Scler. 2011 Jan; 12(1):52-8. PMID: 21271791.
        View in: PubMed
      53. Tosun D, Schuff N, Shaw LM, Trojanowski JQ, Weiner MW. Relationship between CSF biomarkers of Alzheimer's disease and rates of regional cortical thinning in ADNI data. J Alzheimers Dis. 2011; 26 Suppl 3:77-90. PMID: 21971452; PMCID: PMC4587763.
      54. Geng X, Ross TJ, Gu H, Shin W, Zhan W, Chao YP, Lin CP, Schuff N, Yang Y. Diffeomorphic image registration of diffusion MRI using spherical harmonics. IEEE Trans Med Imaging. 2011 Mar; 30(3):747-58. PMID: 21134814; PMCID: PMC3860760.
      55. Apfel BA, Ross J, Hlavin J, Meyerhoff DJ, Metzler TJ, Marmar CR, Weiner MW, Schuff N, Neylan TC. Hippocampal volume differences in Gulf War veterans with current versus lifetime posttraumatic stress disorder symptoms. Biol Psychiatry. 2011 Mar 15; 69(6):541-8. PMID: 21094937; PMCID: PMC3259803.
      56. Chiang GC, Insel PS, Tosun D, Schuff N, Truran-Sacrey D, Raptentsetsang ST, Jack CR, Aisen PS, Petersen RC, Weiner MW. Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects. Neurology. 2010 Nov 30; 75(22):1976-81. PMID: 20980669; PMCID: PMC3014234.
      57. Schuff N, Tosun D, Insel PS, Chiang GC, Truran D, Aisen PS, Jack CR, Weiner MW. Nonlinear time course of brain volume loss in cognitively normal and impaired elders. Neurobiol Aging. 2012 May; 33(5):845-55. PMID: 20855131; PMCID: PMC3032014.
      58. Mueller SG, Schuff N, Yaffe K, Madison C, Miller B, Weiner MW. Hippocampal atrophy patterns in mild cognitive impairment and Alzheimer's disease. Hum Brain Mapp. 2010 Sep; 31(9):1339-47. PMID: 20839293; PMCID: PMC2943433.
      59. Neylan TC, Mueller SG, Wang Z, Metzler TJ, Lenoci M, Truran D, Marmar CR, Weiner MW, Schuff N. Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield. Biol Psychiatry. 2010 Sep 1; 68(5):494-6. PMID: 20598672; PMCID: PMC2921477.
      60. Schuff N, Suhy J, Goldman R, Xu Y, Sun Y, Truran-Sacrey D, Murthy A. An MRI substudy of a donepezil clinical trial in mild cognitive impairment. Neurobiol Aging. 2011 Dec; 32(12):2318.e31-41. PMID: 20541841.
        View in: PubMed
      61. Tosun D, Schuff N, Truran-Sacrey D, Shaw LM, Trojanowski JQ, Aisen P, Peterson R, Weiner MW. Relations between brain tissue loss, CSF biomarkers, and the ApoE genetic profile: a longitudinal MRI study. Neurobiol Aging. 2010 Aug; 31(8):1340-54. PMID: 20570401; PMCID: PMC2902689.
      62. Nezamzadeh M, Matson GB, Young K, Weiner MW, Schuff N. Improved pseudo-continuous arterial spin labeling for mapping brain perfusion. J Magn Reson Imaging. 2010 Jun; 31(6):1419-27. PMID: 20512895; PMCID: PMC3121564.
      63. Schuff N, Zhang Y, Zhan W, Lenoci M, Ching C, Boreta L, Mueller SG, Wang Z, Marmar CR, Weiner MW, Neylan TC. Patterns of altered cortical perfusion and diminished subcortical integrity in posttraumatic stress disorder: an MRI study. Neuroimage. 2011 Jan; 54 Suppl 1:S62-8. PMID: 20483375; PMCID: PMC2945438.
      64. Jack CR, Bernstein MA, Borowski BJ, Gunter JL, Fox NC, Thompson PM, Schuff N, Krueger G, Killiany RJ, Decarli CS, Dale AM, Carmichael OW, Tosun D, Weiner MW. Update on the magnetic resonance imaging core of the Alzheimer's disease neuroimaging initiative. Alzheimers Dement. 2010 May; 6(3):212-20. PMID: 20451869; PMCID: PMC2886577.
      65. Tosun D, Mojabi P, Weiner MW, Schuff N. Joint analysis of structural and perfusion MRI for cognitive assessment and classification of Alzheimer's disease and normal aging. Neuroimage. 2010 Aug 1; 52(1):186-97. PMID: 20406691.
        View in: PubMed
      66. Ho AJ, Hua X, Lee S, Leow AD, Yanovsky I, Gutman B, Dinov ID, Leporé N, Stein JL, Toga AW, Jack CR, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM. Comparing 3 T and 1.5 T MRI for tracking Alzheimer's disease progression with tensor-based morphometry. Hum Brain Mapp. 2010 Apr; 31(4):499-514. PMID: 19780044; PMCID: PMC2875376.
      67. Leung KK, Barnes J, Ridgway GR, Bartlett JW, Clarkson MJ, Macdonald K, Schuff N, Fox NC, Ourselin S. Automated cross-sectional and longitudinal hippocampal volume measurement in mild cognitive impairment and Alzheimer's disease. Neuroimage. 2010 Jul 15; 51(4):1345-59. PMID: 20230901; PMCID: PMC2873209.
      68. Shimizu S, Zhang Y, Laxamana J, Miller BL, Kramer JH, Weiner MW, Schuff N. Concordance and discordance between brain perfusion and atrophy in frontotemporal dementia. Brain Imaging Behav. 2010 Mar; 4(1):46-54. PMID: 20503113; PMCID: PMC2854356.
      69. Wang Z, Neylan TC, Mueller SG, Lenoci M, Truran D, Marmar CR, Weiner MW, Schuff N. Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder. Arch Gen Psychiatry. 2010 Mar; 67(3):296-303. PMID: 20194830; PMCID: PMC2848481.
      70. Rule RR, Schuff N, Miller RG, Weiner MW. Gray matter perfusion correlates with disease severity in ALS. Neurology. 2010 Mar 9; 74(10):821-7. PMID: 20147656; PMCID: PMC2839193.
      71. Hua X, Lee S, Hibar DP, Yanovsky I, Leow AD, Toga AW, Jack CR, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM. Mapping Alzheimer's disease progression in 1309 MRI scans: power estimates for different inter-scan intervals. Neuroimage. 2010 May 15; 51(1):63-75. PMID: 20139010; PMCID: PMC2846999.
      72. Mueller SG, Mack WJ, Mungas D, Kramer JH, Cardenas-Nicolson V, Lavretsky H, Greene M, Schuff N, Chui HC, Weiner MW. Influences of lobar gray matter and white matter lesion load on cognition and mood. Psychiatry Res. 2010 Feb 28; 181(2):90-6. PMID: 20074914; PMCID: PMC2814971.
      73. Schuff N. A new sensitive MRI marker for memory deficits in normal aging. Neurology. 2010 Jan 19; 74(3):188-9. PMID: 20054009.
        View in: PubMed
      74. Chao LL, Buckley ST, Kornak J, Schuff N, Madison C, Yaffe K, Miller BL, Kramer JH, Weiner MW. ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia. Alzheimer Dis Assoc Disord. 2010 Jan-Mar; 24(1):19-27. PMID: 20220321; PMCID: PMC2865220.
      75. Young K, Govind V, Sharma K, Studholme C, Maudsley AA, Schuff N. Multivariate statistical mapping of spectroscopic imaging data. Magn Reson Med. 2010 Jan; 63(1):20-4. PMID: 19953514; PMCID: PMC2849664.
      76. Schuff N, Matsumoto S, Kmiecik J, Studholme C, Du A, Ezekiel F, Miller BL, Kramer JH, Jagust WJ, Chui HC, Weiner MW. Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging. Alzheimers Dement. 2009 Nov; 5(6):454-62. PMID: 19896584; PMCID: PMC2802181.
      77. Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM. Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Hum Brain Mapp. 2009 Sep; 30(9):2766-88. PMID: 19172649; PMCID: PMC2733926.
      78. Nezamzadeh M, Wedeen VJ, Wang R, Zhang Y, Zhan W, Young K, Meyerhoff DJ, Weiner MW, Schuff N. In-vivo investigation of the human cingulum bundle using the optimization of MR diffusion spectrum imaging. Eur J Radiol. 2010 Jul; 75(1):e29-36. PMID: 19615838; PMCID: PMC4266695.
      79. Hua X, Lee S, Yanovsky I, Leow AD, Chou YY, Ho AJ, Gutman B, Toga AW, Jack CR, Bernstein MA, Reiman EM, Harvey DJ, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM. Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with tensor-based morphometry: an ADNI study of 515 subjects. Neuroimage. 2009 Dec; 48(4):668-81. PMID: 19615450; PMCID: PMC2971697.
      80. Jahng GH, Schuff N. Influence of selecting EPI readout-encoding bandwidths on arterial spin labeling perfusion MRI. MAGMA. 2009 Oct; 22(5):287-95. PMID: 19578915.
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      81. Chao LL, Pa J, Duarte A, Schuff N, Weiner MW, Kramer JH, Miller BL, Freeman KM, Johnson JK. Patterns of cerebral hypoperfusion in amnestic and dysexecutive MCI. Alzheimer Dis Assoc Disord. 2009 Jul-Sep; 23(3):245-52. PMID: 19812467; PMCID: PMC2760039.
      82. Gunter JL, Bernstein MA, Borowski BJ, Ward CP, Britson PJ, Felmlee JP, Schuff N, Weiner M, Jack CR. Measurement of MRI scanner performance with the ADNI phantom. Med Phys. 2009 Jun; 36(6):2193-205. PMID: 19610308; PMCID: PMC2754942.
      83. Cardenas VA, Chao LL, Studholme C, Yaffe K, Miller BL, Madison C, Buckley ST, Mungas D, Schuff N, Weiner MW. Brain atrophy associated with baseline and longitudinal measures of cognition. Neurobiol Aging. 2011 Apr; 32(4):572-80. PMID: 19446370; PMCID: PMC2891686.
      84. Zhang Y, Schuff N, Du AT, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW. White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI. Brain. 2009 Sep; 132(Pt 9):2579-92. PMID: 19439421; PMCID: PMC2732263.
      85. Young K, Du AT, Kramer J, Rosen H, Miller B, Weiner M, Schuff N. Patterns of structural complexity in Alzheimer's disease and frontotemporal dementia. Hum Brain Mapp. 2009 May; 30(5):1667-77. PMID: 18677745; PMCID: PMC2736103.
      86. Leow AD, Yanovsky I, Parikshak N, Hua X, Lee S, Toga AW, Jack CR, Bernstein MA, Britson PJ, Gunter JL, Ward CP, Borowski B, Shaw LM, Trojanowski JQ, Fleisher AS, Harvey D, Kornak J, Schuff N, Alexander GE, Weiner MW, Thompson PM. Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition. Neuroimage. 2009 Apr 15; 45(3):645-55. PMID: 19280686; PMCID: PMC2696624.
      87. Schuff N, Woerner N, Boreta L, Kornfield T, Shaw LM, Trojanowski JQ, Thompson PM, Jack CR, Weiner MW. MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers. Brain. 2009 Apr; 132(Pt 4):1067-77. PMID: 19251758; PMCID: PMC2668943.
      88. Zhan W, Zhang Y, Mueller SG, Lorenzen P, Hadjidemetriou S, Schuff N, Weiner MW. Characterization of white matter degeneration in elderly subjects by magnetic resonance diffusion and FLAIR imaging correlation. Neuroimage. 2009 Aug; 47 Suppl 2:T58-65. PMID: 19233296; PMCID: PMC2720418.
      89. Kornak J, Young K, Schuff N, Du A, Maudsley AA, Weiner MW. K-Bayes reconstruction for perfusion MRI. I: concepts and application. J Digit Imaging. 2010 Jun; 23(3):277-86. PMID: 19205805; PMCID: PMC2865632.
      90. Geng X, Ross TJ, Zhan W, Gu H, Chao YP, Lin CP, Christensen GE, Schuff N, Yang Y. Diffusion MRI registration using orientation distribution functions. Inf Process Med Imaging. 2009; 21:626-37. PMID: 19694299; PMCID: PMC3860746.
      91. Schuff N. Potential role of high-field MRI for studies in Parkinson's disease. Mov Disord. 2009; 24 Suppl 2:S684-90. PMID: 19877239.
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      93. Siger M, Schuff N, Zhu X, Miller BL, Weiner MW. Regional myo-inositol concentration in mild cognitive impairment Using 1H magnetic resonance spectroscopic imaging. Alzheimer Dis Assoc Disord. 2009 Jan-Mar; 23(1):57-62. PMID: 18725861; PMCID: PMC3039549.
      94. Van Boven RW, Harrington GS, Hackney DB, Ebel A, Gauger G, Bremner JD, D'Esposito M, Detre JA, Haacke EM, Jack CR, Jagust WJ, Le Bihan D, Mathis CA, Mueller S, Mukherjee P, Schuff N, Chen A, Weiner MW. Advances in neuroimaging of traumatic brain injury and posttraumatic stress disorder. J Rehabil Res Dev. 2009; 46(6):717-57. PMID: 20104401; PMCID: PMC3233771.
      95. Zhang Y, Du AT, Hayasaka S, Jahng GH, Hlavin J, Zhan W, Weiner MW, Schuff N. Patterns of age-related water diffusion changes in human brain by concordance and discordance analysis. Neurobiol Aging. 2010 Nov; 31(11):1991-2001. PMID: 19036473; PMCID: PMC2888604.
      96. Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM. Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Neuroimage. 2009 Mar; 45(1 Suppl):S3-15. PMID: 19041724; PMCID: PMC2733354.
      97. Chao LL, Mueller SG, Buckley ST, Peek K, Raptentsetseng S, Elman J, Yaffe K, Miller BL, Kramer JH, Madison C, Mungas D, Schuff N, Weiner MW. Evidence of neurodegeneration in brains of older adults who do not yet fulfill MCI criteria. Neurobiol Aging. 2010 Mar; 31(3):368-77. PMID: 18550226; PMCID: PMC2814904.
      98. Hadjidemetriou S, Studholme C, Mueller S, Weiner M, Schuff N. Restoration of MRI data for intensity non-uniformities using local high order intensity statistics. Med Image Anal. 2009 Feb; 13(1):36-48. PMID: 18621568; PMCID: PMC2597709.
      99. Jahng GH, Weiner MW, Schuff N. Diffusion anisotropy indexes are sensitive to selecting the EPI readout-encoding bandwidth at high-field MRI. Magn Reson Imaging. 2008 Jun; 26(5):676-82. PMID: 18420366; PMCID: PMC2556209.
      100. Mueller SG, Schuff N, Raptentsetsang S, Elman J, Weiner MW. Selective effect of Apo e4 on CA3 and dentate in normal aging and Alzheimer's disease using high resolution MRI at 4 T. Neuroimage. 2008 Aug 1; 42(1):42-8. PMID: 18534867; PMCID: PMC2597377.
      101. Jack CR, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ, L Whitwell J, Ward C, Dale AM, Felmlee JP, Gunter JL, Hill DL, Killiany R, Schuff N, Fox-Bosetti S, Lin C, Studholme C, DeCarli CS, Krueger G, Ward HA, Metzger GJ, Scott KT, Mallozzi R, Blezek D, Levy J, Debbins JP, Fleisher AS, Albert M, Green R, Bartzokis G, Glover G, Mugler J, Weiner MW. The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods. J Magn Reson Imaging. 2008 Apr; 27(4):685-91. PMID: 18302232; PMCID: PMC2544629.
      102. Hua X, Leow AD, Lee S, Klunder AD, Toga AW, Lepore N, Chou YY, Brun C, Chiang MC, Barysheva M, Jack CR, Bernstein MA, Britson PJ, Ward CP, Whitwell JL, Borowski B, Fleisher AS, Fox NC, Boyes RG, Barnes J, Harvey D, Kornak J, Schuff N, Boreta L, Alexander GE, Weiner MW, Thompson PM. 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry. Neuroimage. 2008 May 15; 41(1):19-34. PMID: 18378167; PMCID: PMC2556222.
      103. Schuff N, Neylan TC, Fox-Bosetti S, Lenoci M, Samuelson KW, Studholme C, Kornak J, Marmar CR, Weiner MW. Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder. Psychiatry Res. 2008 Feb 28; 162(2):147-57. PMID: 18201876; PMCID: PMC2443727.
      104. Hadjidemetriou S, Lorenzen P, Schuff N, Mueller S, Weiner M. Computational atlases of severity of white matter lesions in elderly subjects with MRI. Med Image Comput Comput Assist Interv. 2008; 11(Pt 1):450-8. PMID: 18979778.
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      105. Jagust WJ, Zheng L, Harvey DJ, Mack WJ, Vinters HV, Weiner MW, Ellis WG, Zarow C, Mungas D, Reed BR, Kramer JH, Schuff N, DeCarli C, Chui HC. Neuropathological basis of magnetic resonance images in aging and dementia. Ann Neurol. 2008 Jan; 63(1):72-80. PMID: 18157909; PMCID: PMC2624571.
      106. Carey CL, Kramer JH, Josephson SA, Mungas D, Reed BR, Schuff N, Weiner MW, Chui HC. Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly. Stroke. 2008 Feb; 39(2):397-402. PMID: 18096844; PMCID: PMC2443738.
      107. Schuff N, Zhu XP. Imaging of mild cognitive impairment and early dementia. Br J Radiol. 2007 Dec; 80 Spec No 2:S109-14. PMID: 18445740.
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      108. Young K, Schuff N. Measuring structural complexity in brain images. Neuroimage. 2008 Feb 15; 39(4):1721-30. PMID: 18158255; PMCID: PMC2753612.
      109. Jahng GH, Weiner MW, Schuff N. Improved arterial spin labeling method: applications for measurements of cerebral blood flow in human brain at high magnetic field MRI. Med Phys. 2007 Nov; 34(11):4519-25. PMID: 18072518; PMCID: PMC2443744.
      110. Ebel A, Schuff N. Accelerated 3D echo-planar spectroscopic imaging at 4 Tesla using modified blipped phase-encoding. Magn Reson Med. 2007 Nov; 58(5):1061-6. PMID: 17969111.
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      111. Chao LL, Schuff N, Clevenger EM, Mueller SG, Rosen HJ, Gorno-Tempini ML, Kramer JH, Miller BL, Weiner MW. Patterns of white matter atrophy in frontotemporal lobar degeneration. Arch Neurol. 2007 Nov; 64(11):1619-24. PMID: 17998444; PMCID: PMC2443735.
      112. Boyes RG, Gunter JL, Frost C, Janke AL, Yeatman T, Hill DL, Bernstein MA, Thompson PM, Weiner MW, Schuff N, Alexander GE, Killiany RJ, DeCarli C, Jack CR, Fox NC. Intensity non-uniformity correction using N3 on 3-T scanners with multichannel phased array coils. Neuroimage. 2008 Feb 15; 39(4):1752-62. PMID: 18063391; PMCID: PMC2562663.
      113. Jacob M, Zhu X, Ebel A, Schuff N, Liang ZP. Improved model-based magnetic resonance spectroscopic imaging. IEEE Trans Med Imaging. 2007 Oct; 26(10):1305-18. PMID: 17948722.
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      114. Zhu X, Ebel A, Ji JX, Schuff N. Spectral phase-corrected GRAPPA reconstruction of three-dimensional echo-planar spectroscopic imaging (3D-EPSI). Magn Reson Med. 2007 May; 57(5):815-20. PMID: 17457872.
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      115. Du AT, Schuff N, Kramer JH, Rosen HJ, Gorno-Tempini ML, Rankin K, Miller BL, Weiner MW. Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. Brain. 2007 Apr; 130(Pt 4):1159-66. PMID: 17353226; PMCID: PMC1853284.
      116. Hadjidemetriou S, Studholme C, Mueller S, Weiner M, Schuff N. Restoration of MRI Data for Field Nonuniformities using High Order Neighborhood Statistics. Proc Soc Photo Opt Instrum Eng. 2007 Mar 5; 6512:65121L. PMID: 18193095.
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      117. Mueller SG, Laxer KD, Schuff N, Weiner MW. Voxel-based T2 relaxation rate measurements in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis. Epilepsia. 2007 Feb; 48(2):220-8. PMID: 17295614; PMCID: PMC2744642.
      118. Zhang Y, Schuff N, Jahng GH, Bayne W, Mori S, Schad L, Mueller S, Du AT, Kramer JH, Yaffe K, Chui H, Jagust WJ, Miller BL, Weiner MW. Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology. 2007 Jan 2; 68(1):13-9. PMID: 17200485; PMCID: PMC1941719.
      119. Raj A, Singh G, Zabih R, Kressler B, Wang Y, Schuff N, Weiner M. Bayesian parallel imaging with edge-preserving priors. Magn Reson Med. 2007 Jan; 57(1):8-21. PMID: 17195165; PMCID: PMC2291515.
      120. Ebel A, Maudsley AA, Schuff N. Correction of local B0 shifts in 3D EPSI of the human brain at 4 T. Magn Reson Imaging. 2007 Apr; 25(3):377-80. PMID: 17371727; PMCID: PMC2040064.
      121. Du AT, Jahng GH, Hayasaka S, Kramer JH, Rosen HJ, Gorno-Tempini ML, Rankin KP, Miller BL, Weiner MW, Schuff N. Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI. Neurology. 2006 Oct 10; 67(7):1215-20. PMID: 17030755; PMCID: PMC1779761.
      122. Mueller SG, Schuff N, Weiner MW. Evaluation of treatment effects in Alzheimer's and other neurodegenerative diseases by MRI and MRS. NMR Biomed. 2006 Oct; 19(6):655-68. PMID: 16986115; PMCID: PMC1820857.
      123. Duarte A, Hayasaka S, Du A, Schuff N, Jahng GH, Kramer J, Miller B, Weiner M. Volumetric correlates of memory and executive function in normal elderly, mild cognitive impairment and Alzheimer's disease. Neurosci Lett. 2006 Oct 2; 406(1-2):60-5. PMID: 16904823; PMCID: PMC1779764.
      124. Maudsley AA, Darkazanli A, Alger JR, Hall LO, Schuff N, Studholme C, Yu Y, Ebel A, Frew A, Goldgof D, Gu Y, Pagare R, Rousseau F, Sivasankaran K, Soher BJ, Weber P, Young K, Zhu X. Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging. NMR Biomed. 2006 Jun; 19(4):492-503. PMID: 16763967; PMCID: PMC2673915.
      125. Mueller SG, Stables L, Du AT, Schuff N, Truran D, Cashdollar N, Weiner MW. Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T. Neurobiol Aging. 2007 May; 28(5):719-26. PMID: 16713659; PMCID: PMC1820772.
      126. Zhu X, Schuff N, Kornak J, Soher B, Yaffe K, Kramer JH, Ezekiel F, Miller BL, Jagust WJ, Weiner MW. Effects of Alzheimer disease on fronto-parietal brain N-acetyl aspartate and myo-inositol using magnetic resonance spectroscopic imaging. Alzheimer Dis Assoc Disord. 2006 Apr-Jun; 20(2):77-85. PMID: 16772742; PMCID: PMC1820860.
      127. Zhu XP, Young K, Ebel A, Soher BJ, Kaiser L, Matson G, Weiner WM, Schuff N. Robust analysis of short echo time (1)H MRSI of human brain. Magn Reson Med. 2006 Mar; 55(3):706-11. PMID: 16463345; PMCID: PMC1838963.
      128. Leow AD, Klunder AD, Jack CR, Toga AW, Dale AM, Bernstein MA, Britson PJ, Gunter JL, Ward CP, Whitwell JL, Borowski BJ, Fleisher AS, Fox NC, Harvey D, Kornak J, Schuff N, Studholme C, Alexander GE, Weiner MW, Thompson PM. Longitudinal stability of MRI for mapping brain change using tensor-based morphometry. Neuroimage. 2006 Jun; 31(2):627-40. PMID: 16480900; PMCID: PMC1941663.
      129. Hayasaka S, Du AT, Duarte A, Kornak J, Jahng GH, Weiner MW, Schuff N. A non-parametric approach for co-analysis of multi-modal brain imaging data: application to Alzheimer's disease. Neuroimage. 2006 Apr 15; 30(3):768-79. PMID: 16412666; PMCID: PMC1838962.
      130. Schuff N, Meyerhoff DJ, Mueller S, Chao L, Sacrey DT, Laxer K, Weiner MW. N-acetylaspartate as a marker of neuronal injury in neurodegenerative disease. Adv Exp Med Biol. 2006; 576:241-62; discussion 361-3. PMID: 16802717; PMCID: PMC1779762.
      131. Kramer JH, Rosen HJ, Du AT, Schuff N, Hollnagel C, Weiner MW, Miller BL, Delis DC. Dissociations in hippocampal and frontal contributions to episodic memory performance. Neuropsychology. 2005 Nov; 19(6):799-805. PMID: 16351355; PMCID: PMC1851935.
      132. Ebel A, Maudsley AA, Weiner MW, Schuff N. Achieving sufficient spectral bandwidth for volumetric 1H echo-planar spectroscopic imaging at 4 Tesla. Magn Reson Med. 2005 Sep; 54(3):697-701. PMID: 16086316; PMCID: PMC1851680.
      133. Mungas D, Harvey D, Reed BR, Jagust WJ, DeCarli C, Beckett L, Mack WJ, Kramer JH, Weiner MW, Schuff N, Chui HC. Longitudinal volumetric MRI change and rate of cognitive decline. Neurology. 2005 Aug 23; 65(4):565-71. PMID: 16116117; PMCID: PMC1820871.
      134. Du AT, Schuff N, Chao LL, Kornak J, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. Age effects on atrophy rates of entorhinal cortex and hippocampus. Neurobiol Aging. 2006 May; 27(5):733-40. PMID: 15961190; PMCID: PMC1779763.
      135. Jahng GH, Stables L, Ebel A, Matson GB, Meyerhoff DJ, Weiner MW, Schuff N. Sensitive and fast T1 mapping based on two inversion recovery images and a reference image. Med Phys. 2005 Jun; 32(6):1524-8. PMID: 16013709; PMCID: PMC2443728.
      136. Kaiser LG, Schuff N, Cashdollar N, Weiner MW. Age-related glutamate and glutamine concentration changes in normal human brain: 1H MR spectroscopy study at 4 T. Neurobiol Aging. 2005 May; 26(5):665-72. PMID: 15708441; PMCID: PMC2443746.
      137. Du AT, Schuff N, Chao LL, Kornak J, Ezekiel F, Jagust WJ, Kramer JH, Reed BR, Miller BL, Norman D, Chui HC, Weiner MW. White matter lesions are associated with cortical atrophy more than entorhinal and hippocampal atrophy. Neurobiol Aging. 2005 Apr; 26(4):553-9. PMID: 15653183.
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      138. Young K, Chen Y, Kornak J, Matson GB, Schuff N. Summarizing complexity in high dimensions. Phys Rev Lett. 2005 Mar 11; 94(9):098701. PMID: 15784007.
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      139. Li KL, Zhu X, Hylton N, Jahng GH, Weiner MW, Schuff N. Four-phase single-capillary stepwise model for kinetics in arterial spin labeling MRI. Magn Reson Med. 2005 Mar; 53(3):511-8. PMID: 15723393; PMCID: PMC1941668.
      140. Johnson NA, Jahng GH, Weiner MW, Miller BL, Chui HC, Jagust WJ, Gorno-Tempini ML, Schuff N. Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience. Radiology. 2005 Mar; 234(3):851-9. PMID: 15734937; PMCID: PMC1851934.
      141. Jahng GH, Song E, Zhu XP, Matson GB, Weiner MW, Schuff N. Human brain: reliability and reproducibility of pulsed arterial spin-labeling perfusion MR imaging. Radiology. 2005 Mar; 234(3):909-16. PMID: 15734942; PMCID: PMC1851681.
      142. Kaiser LG, Schuff N, Cashdollar N, Weiner MW. Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla. NMR Biomed. 2005 Feb; 18(1):51-5. PMID: 15468140; PMCID: PMC1820854.
      143. Chao LL, Schuff N, Kramer JH, Du AT, Capizzano AA, O'Neill J, Wolkowitz OM, Jagust WJ, Chui HC, Miller BL, Yaffe K, Weiner MW. Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients. Neurology. 2005 Jan 25; 64(2):282-9. PMID: 15668426; PMCID: PMC1851679.
      144. Ezekiel F, Chao L, Kornak J, Du AT, Cardenas V, Truran D, Jagust W, Chui H, Miller B, Yaffe K, Schuff N, Weiner M. Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus. Alzheimer Dis Assoc Disord. 2004 Oct-Dec; 18(4):196-201. PMID: 15592130; PMCID: PMC1820853.
      145. Rule RR, Suhy J, Schuff N, Gelinas DF, Miller RG, Weiner MW. Reduced NAA in motor and non-motor brain regions in amyotrophic lateral sclerosis: a cross-sectional and longitudinal study. Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Sep; 5(3):141-9. PMID: 15512902; PMCID: PMC2744639.
      146. Kramer JH, Schuff N, Reed BR, Mungas D, Du AT, Rosen HJ, Jagust WJ, Miller BL, Weiner MW, Chui HC. Hippocampal volume and retention in Alzheimer's disease. J Int Neuropsychol Soc. 2004 Jul; 10(4):639-43. PMID: 15327742; PMCID: PMC1820856.
      147. Studholme C, Cardenas V, Blumenfeld R, Schuff N, Rosen HJ, Miller B, Weiner M. Deformation tensor morphometry of semantic dementia with quantitative validation. Neuroimage. 2004 Apr; 21(4):1387-98. PMID: 15050564.
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      148. Du AT, Schuff N, Kramer JH, Ganzer S, Zhu XP, Jagust WJ, Miller BL, Reed BR, Mungas D, Yaffe K, Chui HC, Weiner MW. Higher atrophy rate of entorhinal cortex than hippocampus in AD. Neurology. 2004 Feb 10; 62(3):422-7. PMID: 14872024; PMCID: PMC1820859.
      149. Neylan TC, Lenoci M, Rothlind J, Metzler TJ, Schuff N, Du AT, Franklin KW, Weiss DS, Weiner MW, Marmar CR. Attention, learning, and memory in posttraumatic stress disorder. J Trauma Stress. 2004 Feb; 17(1):41-6. PMID: 15027792; PMCID: PMC2366105.
      150. Kramer JH, Mungas D, Reed BR, Schuff N, Weiner MW, Miller BL, Chui HC. Forgetting in dementia with and without subcortical lacunes. Clin Neuropsychol. 2004 Feb; 18(1):32-40. PMID: 15595356; PMCID: PMC1820864.
      151. Rankin KP, Rosen HJ, Kramer JH, Schauer GF, Weiner MW, Schuff N, Miller BL. Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTD. Dement Geriatr Cogn Disord. 2004; 17(4):328-32. PMID: 15178947; PMCID: PMC2362501.
      152. Boxer AL, Kramer JH, Du AT, Schuff N, Weiner MW, Miller BL, Rosen HJ. Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairment. Neurology. 2003 Dec 9; 61(11):1485-91. PMID: 14663029; PMCID: PMC2744649.
      153. Neylan TC, Schuff N, Lenoci M, Yehuda R, Weiner MW, Marmar CR. Cortisol levels are positively correlated with hippocampal N-acetylaspartate. Biol Psychiatry. 2003 Nov 15; 54(10):1118-21. PMID: 14625155; PMCID: PMC2733352.
      154. Zhu XP, Du AT, Jahng GH, Soher BJ, Maudsley AA, Weiner MW, Schuff N. Magnetic resonance spectroscopic imaging reconstruction with deformable shape-intensity models. Magn Reson Med. 2003 Sep; 50(3):474-82. PMID: 12939754; PMCID: PMC1851686.
      155. Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, Jagust WJ, Chui HC, Kramer JH, Reed BR, Miller BL, Yaffe K, Weiner MW. Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD. Neurology. 2003 Aug 12; 61(3):358-64. PMID: 12913198; PMCID: PMC1820863.
      156. Boxer AL, Rankin KP, Miller BL, Schuff N, Weiner M, Gorno-Tempini ML, Rosen HJ. Cinguloparietal atrophy distinguishes Alzheimer disease from semantic dementia. Arch Neurol. 2003 Jul; 60(7):949-56. PMID: 12873851.
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      157. Cardenas VA, Du AT, Hardin D, Ezekiel F, Weber P, Jagust WJ, Chui HC, Schuff N, Weiner MW. Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia. Neurobiol Aging. 2003 Jul-Aug; 24(4):537-44. PMID: 12714110.
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      158. Du AT, Schuff N, Zhu XP, Jagust WJ, Miller BL, Reed BR, Kramer JH, Mungas D, Yaffe K, Chui HC, Weiner MW. Atrophy rates of entorhinal cortex in AD and normal aging. Neurology. 2003 Feb 11; 60(3):481-6. PMID: 12578931; PMCID: PMC1851672.
      159. Jahng GH, Zhu XP, Matson GB, Weiner MW, Schuff N. Improved perfusion-weighted MRI by a novel double inversion with proximal labeling of both tagged and control acquisitions. Magn Reson Med. 2003 Feb; 49(2):307-14. PMID: 12541251; PMCID: PMC1851685.
      160. Vermathen P, Laxer KD, Schuff N, Matson GB, Weiner MW. Evidence of neuronal injury outside the medial temporal lobe in temporal lobe epilepsy: N-acetylaspartate concentration reductions detected with multisection proton MR spectroscopic imaging--initial experience. Radiology. 2003 Jan; 226(1):195-202. PMID: 12511690; PMCID: PMC2753262.
      161. Rosen HJ, Perry RJ, Murphy J, Kramer JH, Mychack P, Schuff N, Weiner M, Levenson RW, Miller BL. Emotion comprehension in the temporal variant of frontotemporal dementia. Brain. 2002 Oct; 125(Pt 10):2286-95. PMID: 12244085.
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      162. Capizzano AA, Vermathen P, Laxer KD, Matson GB, Maudsley AA, Soher BJ, Schuff NW, Weiner MW. Multisection proton MR spectroscopy for mesial temporal lobe epilepsy. AJNR Am J Neuroradiol. 2002 Sep; 23(8):1359-68. PMID: 12223379; PMCID: PMC2753243.
      163. Hsu YY, Schuff N, Du AT, Mark K, Zhu X, Hardin D, Weiner MW. Comparison of automated and manual MRI volumetry of hippocampus in normal aging and dementia. J Magn Reson Imaging. 2002 Sep; 16(3):305-10. PMID: 12205587; PMCID: PMC1851676.
      164. O'Neill J, Schuff N, Marks WJ, Feiwell R, Aminoff MJ, Weiner MW. Quantitative 1H magnetic resonance spectroscopy and MRI of Parkinson's disease. Mov Disord. 2002 Sep; 17(5):917-27. PMID: 12360540.
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      165. Du AT, Schuff N, Laakso MP, Zhu XP, Jagust WJ, Yaffe K, Kramer JH, Miller BL, Reed BR, Norman D, Chui HC, Weiner MW. Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus. Neurology. 2002 Jun 11; 58(11):1635-41. PMID: 12058091; PMCID: PMC1820858.
      166. Hsu YY, Schuff N, Amend DL, Du AT, Norman D, Chui HC, Jagust WJ, Weiner MW. Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunes. Alzheimer Dis Assoc Disord. 2002 Apr-Jun; 16(2):58-64. PMID: 12040300; PMCID: PMC1820852.
      167. Schuff N, Capizzano AA, Du AT, Amend DL, O'Neill J, Norman D, Kramer J, Jagust W, Miller B, Wolkowitz OM, Yaffe K, Weiner MW. Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD. Neurology. 2002 Mar 26; 58(6):928-35. PMID: 11914410; PMCID: PMC1851674.
      168. Suhy J, Miller RG, Rule R, Schuff N, Licht J, Dronsky V, Gelinas D, Maudsley AA, Weiner MW. Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI. Neurology. 2002 Mar 12; 58(5):773-9. PMID: 11889242; PMCID: PMC2733360.
      169. Rosen HJ, Gorno-Tempini ML, Goldman WP, Perry RJ, Schuff N, Weiner M, Feiwell R, Kramer JH, Miller BL. Patterns of brain atrophy in frontotemporal dementia and semantic dementia. Neurology. 2002 Jan 22; 58(2):198-208. PMID: 11805245.
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      170. Rosen HJ, Kramer JH, Gorno-Tempini ML, Schuff N, Weiner M, Miller BL. Patterns of cerebral atrophy in primary progressive aphasia. Am J Geriatr Psychiatry. 2002 Jan-Feb; 10(1):89-97. PMID: 11790639.
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      171. Schuff N, Neylan TC, Lenoci MA, Du AT, Weiss DS, Marmar CR, Weiner MW. Decreased hippocampal N-acetylaspartate in the absence of atrophy in posttraumatic stress disorder. Biol Psychiatry. 2001 Dec 15; 50(12):952-9. PMID: 11750891; PMCID: PMC2733624.
      172. Deicken RF, Feiwell R, Schuff N, Soher B. Evidence for altered cerebellar vermis neuronal integrity in schizophrenia. Psychiatry Res. 2001 Oct 1; 107(3):125-34. PMID: 11566429.
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      173. Du AT, Schuff N, Amend D, Laakso MP, Hsu YY, Jagust WJ, Yaffe K, Kramer JH, Reed B, Norman D, Chui HC, Weiner MW. Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2001 Oct; 71(4):441-7. PMID: 11561025; PMCID: PMC1763497.
      174. Wiedermann D, Schuff N, Matson GB, Soher BJ, Du AT, Maudsley AA, Weiner MW. Short echo time multislice proton magnetic resonance spectroscopic imaging in human brain: metabolite distributions and reliability. Magn Reson Imaging. 2001 Oct; 19(8):1073-80. PMID: 11711231.
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      175. Schuff N, Ezekiel F, Gamst AC, Amend DL, Capizzano AA, Maudsley AA, Weiner MW. Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging. Magn Reson Med. 2001 May; 45(5):899-907. PMID: 11323817; PMCID: PMC1851682.
      176. Schuff N, Rooney WD, Miller R, Gelinas DF, Amend DL, Maudsley AA, Weiner MW. Reanalysis of multislice (1)H MRSI in amyotrophic lateral sclerosis. Magn Reson Med. 2001 Mar; 45(3):513-6. PMID: 11241711.
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      177. Deicken RF, Eliaz Y, Feiwell R, Schuff N. Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder. Psychiatry Res. 2001 Feb 28; 106(1):35-45. PMID: 11231098.
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      178. Hsu YY, Du AT, Schuff N, Weiner MW. Magnetic resonance imaging and magnetic resonance spectroscopy in dementias. J Geriatr Psychiatry Neurol. 2001; 14(3):145-66. PMID: 11563438; PMCID: PMC1857299.
      179. Soher BJ, Vermathen P, Schuff N, Wiedermann D, Meyerhoff DJ, Weiner MW, Maudsley AA. Short TE in vivo (1)H MR spectroscopic imaging at 1.5 T: acquisition and automated spectral analysis. Magn Reson Imaging. 2000 Nov; 18(9):1159-65. PMID: 11118771.
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      180. Capizzano AA, Schuff N, Amend DL, Tanabe JL, Norman D, Maudsley AA, Jagust W, Chui HC, Fein G, Segal MR, Weiner MW. Subcortical ischemic vascular dementia: assessment with quantitative MR imaging and 1H MR spectroscopy. AJNR Am J Neuroradiol. 2000 Apr; 21(4):621-30. PMID: 10782769; PMCID: PMC1945115.
      181. Deicken RF, Johnson C, Eliaz Y, Schuff N. Reduced concentrations of thalamic N-acetylaspartate in male patients with schizophrenia. Am J Psychiatry. 2000 Apr; 157(4):644-7. PMID: 10739431.
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      182. O'Neill J, Eberling JL, Schuff N, Jagust W, Reed B, Soto G, Ezekiel F, Klein G, Weiner MW. Method to correlate 1H MRSI and 18FDG-PET. Magn Reson Med. 2000 Feb; 43(2):244-50. PMID: 10680688; PMCID: PMC1993915.
      183. Meyerhoff DJ, Bloomer C, Schuff N, Ezekiel F, Norman D, Clark W, Weiner MW, Fein G. Cortical metabolite alterations in abstinent cocaine and cocaine/alcohol-dependent subjects: proton magnetic resonance spectroscopic imaging. Addict Biol. 1999 Oct; 4(4):405-19. PMID: 20575809; PMCID: PMC2893339.
      184. Schuff N, Amend DL, Knowlton R, Norman D, Fein G, Weiner MW. Age-related metabolite changes and volume loss in the hippocampus by magnetic resonance spectroscopy and imaging. Neurobiol Aging. 1999 May-Jun; 20(3):279-85. PMID: 10588575; PMCID: PMC2733348.
      185. Rooney WD, Miller RG, Gelinas D, Schuff N, Maudsley AA, Weiner MW. Decreased N-acetylaspartate in motor cortex and corticospinal tract in ALS. Neurology. 1998 Jun; 50(6):1800-5. PMID: 9633731.
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      186. Deicken RF, Zhou L, Schuff N, Fein G, Weiner MW. Hippocampal neuronal dysfunction in schizophrenia as measured by proton magnetic resonance spectroscopy. Biol Psychiatry. 1998 Apr 1; 43(7):483-8. PMID: 9547926.
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      187. Schuff N, Amend DL, Meyerhoff DJ, Tanabe JL, Norman D, Fein G, Weiner MW. Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain. Radiology. 1998 Apr; 207(1):91-102. PMID: 9530304; PMCID: PMC2753252.
      188. Schuff N, Amend D, Ezekiel F, Steinman SK, Tanabe J, Norman D, Jagust W, Kramer JH, Mastrianni JA, Fein G, Weiner MW. Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study. Neurology. 1997 Dec; 49(6):1513-21. PMID: 9409338.
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      189. Deicken RF, Zhou L, Schuff N, Weiner MW. Proton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia. Schizophr Res. 1997 Oct 17; 27(1):65-71. PMID: 9373896.
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      190. Rooney WD, Goodkin DE, Schuff N, Meyerhoff DJ, Norman D, Weiner MW. 1H MRSI of normal appearing white matter in multiple sclerosis. Mult Scler. 1997 Aug; 3(4):231-7. PMID: 9372505.
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      191. Tanabe JL, Ezekiel F, Jagust WJ, Schuff N, Fein G. Volumetric method for evaluating magnetization transfer ratio of tissue categories: application to areas of white matter signal hyperintensity in the elderly. Radiology. 1997 Aug; 204(2):570-5. PMID: 9240555.
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      192. Schuff N, Marmar CR, Weiss DS, Neylan TC, Schoenfeld F, Fein G, Weiner MW. Reduced hippocampal volume and n-acetyl aspartate in posttraumatic stress disorder. Ann N Y Acad Sci. 1997 Jun 21; 821:516-20. PMID: 9238242.
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      193. Tanabe JL, Amend D, Schuff N, DiSclafani V, Ezekiel F, Norman D, Fein G, Weiner MW. Tissue segmentation of the brain in Alzheimer disease. AJNR Am J Neuroradiol. 1997 Jan; 18(1):115-23. PMID: 9010529.
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      194. Haupt CI, Schuff N, Weiner MW, Maudsley AA. Removal of lipid artifacts in 1H spectroscopic imaging by data extrapolation. Magn Reson Med. 1996 May; 35(5):678-87. PMID: 8722819; PMCID: PMC2733339.
      195. Hornung P.A. and Schuff N., Vol. 38 (9), 160, (1992). . Clinical Chemistry. Non-invasive Imaging and Spectroscopy - Broad Applications using Magnetic Resonance. 1992; 38(9):160-166.
      196. Bartels M, Gunther U, Albert K, Mann K, Schuff N, Stuckstedte H. . Biol Psychiatry. 19F nuclear magnetic resonance spectroscopy of neuroleptics: the first in vivo pharmacokinetics of trifluoperazine in the rat brain and the first in vivo spectrum of fluphenazine in the human brain. 1991; 30(7):656-662.
      197. Schuff N., Hornung P.A. and Williams E.H. , Vol. 217, 55, (1991). . Proceedings of the Material Research Society,. A Study of Changes in Poly(methyl-methacrylate) PMMA Resulting from the Adsorption of Methanol using NMR Imaging. 1991; 217:55.
      198. Jehenson P., Westphal M. and Schuff N. . Journal of Magnetic Resonance. Analytical Method for the Compensation of Eddy-Current Effects Induced by Pulsed Magnetic Field Gradients in NMR Systems. 1990; (90):264-278.
      199. Durst P., Schuff N., Croq M.A., Mokrani M.C. and Macher J.P. . Journal of Psychology Research: Neuroimaging,. Non-invasive In-vivo Detection of a Fluorinated Neuroleptic in the Human Brain by 19F NMR Spectroscopy. 1990; 35(2).
      200. Norris D., Schuff N. and Leibfritz D. . Journal of Magnetic Resonance. INEPT Enhanced 13C Spectroscopy using Double-tuned Surface Coils. 1988; (78):362-366.
      201. Rodiek S., Juretschke H-P., Hoepfel D. and Schuff N. . RoFo, Fortschritte auf dem Gebiet der Rontgenstrahlung und Nuklearmedizin. MR Tomographie und Spektroskopie der Skelettmuskulatur bei hohen Magnetfeldstarken. 1986; (144):89-94.
      202. Schuff N. and Haeberlen U. . Journal of Magnetic Resonance. Rate Constants of Flipping, and Shielding Tensors of Stationary Water Molecules in Potassium Oxalate Monohydrate. 1985; 62:406-416.
      203. Schuff N. and Haeberlen U. . Journal of Magnetic Resonance. 2D Correlation Spectroscopy in Homonuclear Dipolar-Coupled Solids. Journal of Magnetic Resonance. 1983; ( 52):267-281.
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