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Yvonne Wu, MD, MPH

TitleProfessor
SchoolUCSF School of Medicine
DepartmentNeurology
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPediatrics and Neurology Residencies1998School of Medicine
    UC BerkeleyM.P.H.2000Public Health
    Harvard UniversityM.D.1992School of Medicine
    Yale B. S.1988Psychobiology

    Collapse Overview 
    Collapse Overview
    Dr. Yvonne Wu is a child neurologist and epidemiologist with expertise in newborn brain injury and cerebral palsy (CP). After obtaining a BS from Yale and an MD from Harvard Medical School, she completed her Child Neurology Residency training at University of California, San Francisco (UCSF) and obtained a MPH in Epidemiology at University of California, Berkeley. The goal of Dr. Wu's research is to develop new strategies to prevent CP. Her research has been funded by NIH, Thrasher Research Fund, CP Alliance, CP International Research Foundation and others. Dr. Wu has been the recipient of several teaching awards at UCSF. She is on the Editorial Boards of Pediatric Neurology and Journal of Child Neurology, and served as an elected Council Member for the Society for Pediatric Research. Dr. Wu has published over 77 papers, including in high impact journals such as JAMA, NEJM, and Pediatrics. She authors UpToDate chapters on hypoxic-ischemic encephalopathy, and has written several review chapters on perinatal stroke and cerebral palsy. Dr. Dr. Wu has studied erythropoietin as a novel neuroprotective therapy for newborn infants with hypoxic-ischemic brain injury. She was the PI of NEAT and NEAT O (Phase I and Phase II studies), and is currently the PI of a large NIH-funded multi-center Phase III clinical trial (HEAL) studying erythropoietin in this population (www.heal-trial.org).


    Collapse Research 
    Collapse Research Activities and Funding
    High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) CCC
    NIH/NINDS U01NS092764Sep 30, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes (NEATO)
    Thrasher Research Fund Sep 1, 2013 - Aug 31, 2017
    Role: PI
    Inflammation and Cerebral Palsy in Term Infants
    NIH/NINDS K02NS046688Jan 1, 2005 - Dec 31, 2011
    Role: Principal Investigator
    Neonatal Erythropoietin for Asphyxia in Term Infants (NEAT)
    Thrasher Research Fund
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News
    Collapse Clinical Trials
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Frymoyer A, Juul SE, Massaro AN, Bammler TK, Wu YW. High-Dose Erythropoietin Population Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia. Pediatr Res. 2017 Jan 18. PMID: 28099423.
      View in: PubMed
    2. Wu YW, Kuzniewicz MW, Croen L, Walsh EM, McCulloch CE, Newman TB. Risk of Autism Associated With Hyperbilirubinemia and Phototherapy. Pediatrics. 2016 Oct; 138(4). PMID: 27669736.
      View in: PubMed
    3. Wu YW, Mathur AM, Chang T, McKinstry RC, Mulkey SB, Mayock DE, Van Meurs KP, Rogers EE, Gonzalez FF, Comstock BA, Juul SE, Msall ME, Bonifacio SL, Glass HC, Massaro AN, Dong L, Tan KW, Heagerty PJ, Ballard RA. High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediatrics. 2016 Jun; 137(6). PMID: 27244862.
      View in: PubMed
    4. Ananth AL, Robichaux-Viehoever A, Kim YM, Hanson-Kahn A, Cox R, Enns GM, Strober J, Willing M, Schlaggar BL, Wu Y, Bernstein JA. Clinical Course of Six Children With GNAO1 Mutations Causing a Severe and Distinctive Movement Disorder. Pediatr Neurol. 2016 Jun; 59:81-4. PMID: 27068059.
      View in: PubMed
    5. Schwarz MD, Li M, Tsao J, Zhou R, Wu YW, Sankar R, Wu JY, Hussain SA. A lack of clinically apparent vision loss among patients treated with vigabatrin with infantile spasms: The UCLA experience. Epilepsy Behav. 2016 Apr; 57(Pt A):29-33. PMID: 26921595.
      View in: PubMed
    6. Bear JJ, Wu YW. Maternal Infections During Pregnancy and Cerebral Palsy in the Child. Pediatr Neurol. 2016 Apr; 57:74-9. PMID: 26857522.
      View in: PubMed
    7. Shang L, Henderson LB, Cho MT, Petrey DS, Fong CT, Haude KM, Shur N, Lundberg J, Hauser N, Carmichael J, Innis J, Schuette J, Wu YW, Asaikar S, Pearson M, Folk L, Retterer K, Monaghan KG, Chung WK. De novo missense variants in PPP2R5D are associated with intellectual disability, macrocephaly, hypotonia, and autism. Neurogenetics. 2016 Jan; 17(1):43-9. PMID: 26576547.
      View in: PubMed
    8. Wu YW, Sullivan J, McDaniel SS, Meisler MH, Walsh EM, Li SX, Kuzniewicz MW. Incidence of Dravet Syndrome in a US Population. Pediatrics. 2015 Nov; 136(5):e1310-5. PMID: 26438699; PMCID: PMC4621800 [Available on 11/01/16].
    9. Wickremasinghe AC, Risley RJ, Kuzniewicz MW, Wu YW, Walsh EM, Wi S, McCulloch CE, Newman TB. Risk of Sensorineural Hearing Loss and Bilirubin Exchange Transfusion Thresholds. Pediatrics. 2015 Sep; 136(3):505-12. PMID: 26283777.
      View in: PubMed
    10. Wu YW, Mehravari AS, Numis AL, Gross P. Cerebral palsy research funding from the National Institutes of Health, 2001 to 2013. Dev Med Child Neurol. 2015 Oct; 57(10):936-41. PMID: 25951080.
      View in: PubMed
    11. Wu YW, Gonzalez FF. Erythropoietin: a novel therapy for hypoxic-ischaemic encephalopathy? Dev Med Child Neurol. 2015 Apr; 57 Suppl 3:34-9. PMID: 25800490.
      View in: PubMed
    12. Wu YW, Kuzniewicz MW, Wickremasinghe AC, Walsh EM, Wi S, McCulloch CE, Newman TB. Risk for cerebral palsy in infants with total serum bilirubin levels at or above the exchange transfusion threshold: a population-based study. JAMA Pediatr. 2015 Mar; 169(3):239-46. PMID: 25560920.
      View in: PubMed
    13. Rogers EE, Bonifacio SL, Glass HC, Juul SE, Chang T, Mayock DE, Durand DJ, Song D, Barkovich AJ, Ballard RA, Wu YW. Erythropoietin and hypothermia for hypoxic-ischemic encephalopathy. Pediatr Neurol. 2014 Nov; 51(5):657-62. PMID: 25439577; PMCID: PMC4402201.
    14. Kuzniewicz MW, Wickremasinghe AC, Wu YW, McCulloch CE, Walsh EM, Wi S, Newman TB. Incidence, etiology, and outcomes of hazardous hyperbilirubinemia in newborns. Pediatrics. 2014 Sep; 134(3):504-9. PMID: 25092943.
      View in: PubMed
    15. Brooks JC, Strauss DJ, Shavelle RM, Tran LM, Rosenbloom L, Wu YW. Recent trends in cerebral palsy survival. Part II: individual survival prognosis. Dev Med Child Neurol. 2014 Nov; 56(11):1065-71. PMID: 25041081.
      View in: PubMed
    16. Brooks JC, Strauss DJ, Shavelle RM, Tran LM, Rosenbloom L, Wu YW. Recent trends in cerebral palsy survival. Part I: period and cohort effects. Dev Med Child Neurol. 2014 Nov; 56(11):1059-64. PMID: 24966011.
      View in: PubMed
    17. Khankhanian P, Baranzini SE, Johnson BA, Madireddy L, Nickles D, Croen LA, Wu YW. Sequencing of the IL6 gene in a case-control study of cerebral palsy in children. BMC Med Genet. 2013; 14:126. PMID: 24314052; PMCID: PMC3881497.
    18. Wu YW, Hess CP, Singhal NS, Groden C, Toro C. Idiopathic basal ganglia calcifications: an atypical presentation of PKAN. Pediatr Neurol. 2013 Nov; 49(5):351-4. PMID: 23968566.
      View in: PubMed
    19. Crisham Janik MD, Newman TB, Cheng YW, Xing G, Gilbert WM, Wu YW. Maternal diagnosis of obesity and risk of cerebral palsy in the child. J Pediatr. 2013 Nov; 163(5):1307-12. PMID: 23932316; PMCID: PMC3812421.
    20. Grether JK, Qian Y, Croughan MS, Wu YW, Schembri M, Camarano L, Croen LA. Is infertility associated with childhood autism? J Autism Dev Disord. 2013 Mar; 43(3):663-72. PMID: 22777105.
      View in: PubMed
    21. Gelfand AA, Croen LA, Torres AR, Wu YW. Genetic risk factors for perinatal arterial ischemic stroke. Pediatr Neurol. 2013 Jan; 48(1):36-41. PMID: 23290018; PMCID: PMC3539155.
    22. Gardner MA, Li BC, Wu YW, Slavotinek AM. Intraparenchymal hemorrhage in a neonate with cleidocranial dysostosis. Pediatr Neurol. 2012 Dec; 47(6):455-7. PMID: 23127269.
      View in: PubMed
    23. Wu YW, Bauer LA, Ballard RA, Ferriero DM, Glidden DV, Mayock DE, Chang T, Durand DJ, Song D, Bonifacio SL, Gonzalez FF, Glass HC, Juul SE. Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics. Pediatrics. 2012 Oct; 130(4):683-91. PMID: 23008465; PMCID: PMC3457622.
    24. Lang TC, Fuentes-Afflick E, Gilbert WM, Newman TB, Xing G, Wu YW. Cerebral palsy among Asian ethnic subgroups. Pediatrics. 2012 Apr; 129(4):e992-8. PMID: 22430449; PMCID: PMC3313638.
    25. Wu YW, Croen LA, Vanderwerf A, Gelfand AA, Torres AR. Candidate genes and risk for CP: a population-based study. Pediatr Res. 2011 Dec; 70(6):642-6. PMID: 21857382; PMCID: PMC3210921.
    26. Jeng S, Gupta N, Wrensch M, Zhao S, Wu YW. Prevalence of congenital hydrocephalus in California, 1991-2000. Pediatr Neurol. 2011 Aug; 45(2):67-71. PMID: 21763944.
      View in: PubMed
    27. Sukhov A, Wu Y, Xing G, Smith LH, Gilbert WM. Risk factors associated with cerebral palsy in preterm infants. J Matern Fetal Neonatal Med. 2012 Jan; 25(1):53-7. PMID: 21463212.
      View in: PubMed
    28. Brooks JC, Fisher-Owens SA, Wu YW, Strauss DJ, Newman TB. Evidence suggests there was not a "resurgence" of kernicterus in the 1990s. Pediatrics. 2011 Apr; 127(4):672-9. PMID: 21444599.
      View in: PubMed
    29. Wu YW, Xing G, Fuentes-Afflick E, Danielson B, Smith LH, Gilbert WM. Racial, ethnic, and socioeconomic disparities in the prevalence of cerebral palsy. Pediatrics. 2011 Mar; 127(3):e674-81. PMID: 21339278; PMCID: PMC3387914.
    30. Wu YW, Pham TN, Danielsen B, Towner D, Smith L, Johnston SC. Nighttime delivery and risk of neonatal encephalopathy. Am J Obstet Gynecol. 2011 Jan; 204(1):37.e1-6. PMID: 21074140.
      View in: PubMed
    31. Wu YW, Croen LA, Torres AR, Van De Water J, Grether JK, Hsu NN. Interleukin-6 genotype and risk for cerebral palsy in term and near-term infants. Ann Neurol. 2009 Nov; 66(5):663-70. PMID: 19938160.
      View in: PubMed
    32. Agrawal N, Johnston SC, Wu YW, Sidney S, Fullerton HJ. Imaging data reveal a higher pediatric stroke incidence than prior US estimates. Stroke. 2009 Nov; 40(11):3415-21. PMID: 19762687; PMCID: PMC3387270.
    33. Aitken LA, Lindan CE, Sidney S, Gupta N, Barkovich AJ, Sorel M, Wu YW. Chiari type I malformation in a pediatric population. Pediatr Neurol. 2009 Jun; 40(6):449-54. PMID: 19433279; PMCID: PMC3176758.
    34. Armstrong-Wells J, Johnston SC, Wu YW, Sidney S, Fullerton HJ. Prevalence and predictors of perinatal hemorrhagic stroke: results from the kaiser pediatric stroke study. Pediatrics. 2009 Mar; 123(3):823-8. PMID: 19255009.
      View in: PubMed
    35. Jordan LC, Johnston SC, Wu YW, Sidney S, Fullerton HJ. The importance of cerebral aneurysms in childhood hemorrhagic stroke: a population-based study. Stroke. 2009 Feb; 40(2):400-5. PMID: 19023102; PMCID: PMC2764740.
    36. Glass HC, Pham TN, Danielsen B, Towner D, Glidden D, Wu YW. Antenatal and intrapartum risk factors for seizures in term newborns: a population-based study, California 1998-2002. J Pediatr. 2009 Jan; 154(1):24-28.e1. PMID: 18760807; PMCID: PMC2635430.
    37. Anderson JE, Teitel D, Wu YW. Venous hum causing tinnitus: case report and review of the literature. Clin Pediatr (Phila). 2009 Jan; 48(1):87-8. PMID: 18626105.
      View in: PubMed
    38. Liljestrand P, Jeremy RJ, Wu YW, Ferriero DM, Escobar GJ, Newman TB. Use of the motor performance checklist to study motor outcomes in 5-year-olds. J Paediatr Child Health. 2009 Jun; 45(6):368-74. PMID: 17803665.
      View in: PubMed
    39. Day SM, Wu YW, Strauss DJ, Shavelle RM, Reynolds RJ. Change in ambulatory ability of adolescents and young adults with cerebral palsy. Dev Med Child Neurol. 2007 Sep; 49(9):647-53. PMID: 17718819.
      View in: PubMed
    40. Wu Y, Green NL, Wrensch MR, Zhao S, Gupta N. Ventriculoperitoneal shunt complications in California: 1990 to 2000. Neurosurgery. 2007 Sep; 61(3):557-62; discussion 562-3. PMID: 17881969.
      View in: PubMed
    41. Fullerton HJ, Wu YW, Sidney S, Johnston SC. Recurrent hemorrhagic stroke in children: a population-based cohort study. Stroke. 2007 Oct; 38(10):2658-62. PMID: 17761928.
      View in: PubMed
    42. Escobar GJ, Liljestrand P, Hudes ES, Ferriero DM, Wu YW, Jeremy RJ, Newman TB. Five-year neurodevelopmental outcome of neonatal dehydration. J Pediatr. 2007 Aug; 151(2):127-33, 133.e1. PMID: 17643761; PMCID: PMC2233705.
    43. Gupta N, Park J, Solomon C, Kranz DA, Wrensch M, Wu YW. Long-term outcomes in patients with treated childhood hydrocephalus. J Neurosurg. 2007 May; 106(5 Suppl):334-9. PMID: 17566197.
      View in: PubMed
    44. Hecht JH, Glenn OA, Wara DW, Wu YW. JC virus granule cell neuronopathy in a child with CD40 ligand deficiency. Pediatr Neurol. 2007 Mar; 36(3):186-9. PMID: 17352955.
      View in: PubMed
    45. Fullerton HJ, Wu YW, Sidney S, Johnston SC. Risk of recurrent childhood arterial ischemic stroke in a population-based cohort: the importance of cerebrovascular imaging. Pediatrics. 2007 Mar; 119(3):495-501. PMID: 17332202.
      View in: PubMed
    46. Day SM, Strauss DJ, Vachon PJ, Rosenbloom L, Shavelle RM, Wu YW. Growth patterns in a population of children and adolescents with cerebral palsy. Dev Med Child Neurol. 2007 Mar; 49(3):167-71. PMID: 17355471.
      View in: PubMed
    47. Wu YW, Croen LA, Henning L, Najjar DV, Schembri M, Croughan MS. Potential association between infertility and spinal neural tube defects in offspring. Birth Defects Res A Clin Mol Teratol. 2006 Oct; 76(10):718-22. PMID: 17022023; PMCID: PMC3407570.
    48. Miller SP, Wu YW, Lee J, Lammer EJ, Iovannisci DM, Glidden DV, Bonifacio SL, Collins A, Shaw GM, Barkovich AJ, Ferriero DM. Candidate gene polymorphisms do not differ between newborns with stroke and normal controls. Stroke. 2006 Nov; 37(11):2678-83. PMID: 17008620.
      View in: PubMed
    49. Wu YW, Lindan CE, Henning LH, Yoshida CK, Fullerton HJ, Ferriero DM, Barkovich AJ, Croen LA. Neuroimaging abnormalities in infants with congenital hemiparesis. Pediatr Neurol. 2006 Sep; 35(3):191-6. PMID: 16939859.
      View in: PubMed
    50. Wu YW, Croen LA, Shah SJ, Newman TB, Najjar DV. Cerebral palsy in a term population: risk factors and neuroimaging findings. Pediatrics. 2006 Aug; 118(2):690-7. PMID: 16882824.
      View in: PubMed
    51. Newman TB, Liljestrand P, Jeremy RJ, Ferriero DM, Wu YW, Hudes ES, Escobar GJ. Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter or more. N Engl J Med. 2006 May 4; 354(18):1889-900. PMID: 16672700.
      View in: PubMed
    52. Wu YW, Lynch JK, Nelson KB. Perinatal arterial stroke: understanding mechanisms and outcomes. Semin Neurol. 2005 Dec; 25(4):424-34. PMID: 16341998.
      View in: PubMed
    53. Lee J, Croen LA, Lindan C, Nash KB, Yoshida CK, Ferriero DM, Barkovich AJ, Wu YW. Predictors of outcome in perinatal arterial stroke: a population-based study. Ann Neurol. 2005 Aug; 58(2):303-8. PMID: 16010659.
      View in: PubMed
    54. Miller SP, Ramaswamy V, Michelson D, Barkovich AJ, Holshouser B, Wycliffe N, Glidden DV, Deming D, Partridge JC, Wu YW, Ashwal S, Ferriero DM. Patterns of brain injury in term neonatal encephalopathy. J Pediatr. 2005 Apr; 146(4):453-60. PMID: 15812446.
      View in: PubMed
    55. Lee J, Croen LA, Backstrand KH, Yoshida CK, Henning LH, Lindan C, Ferriero DM, Fullerton HJ, Barkovich AJ, Wu YW. Maternal and infant characteristics associated with perinatal arterial stroke in the infant. JAMA. 2005 Feb 9; 293(6):723-9. PMID: 15701914.
      View in: PubMed
    56. Wu YW, Backstrand KH, Zhao S, Fullerton HJ, Johnston SC. Declining diagnosis of birth asphyxia in California: 1991-2000. Pediatrics. 2004 Dec; 114(6):1584-90. PMID: 15574618.
      View in: PubMed
    57. Wu YW, Day SM, Strauss DJ, Shavelle RM. Prognosis for ambulation in cerebral palsy: a population-based study. Pediatrics. 2004 Nov; 114(5):1264-71. PMID: 15520106.
      View in: PubMed
    58. Wu YW, March WM, Croen LA, Grether JK, Escobar GJ, Newman TB. Perinatal stroke in children with motor impairment: a population-based study. Pediatrics. 2004 Sep; 114(3):612-9. PMID: 15342829.
      View in: PubMed
    59. Jackson RA, Gibson KA, Wu YW, Croughan MS. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol. 2004 Mar; 103(3):551-63. PMID: 14990421.
      View in: PubMed
    60. Wu YW, Escobar GJ, Grether JK, Croen LA, Greene JD, Newman TB. Chorioamnionitis and cerebral palsy in term and near-term infants. JAMA. 2003 Nov 26; 290(20):2677-84. PMID: 14645309.
      View in: PubMed
    61. Fullerton HJ, Wu YW, Zhao S, Johnston SC. Risk of stroke in children: ethnic and gender disparities. Neurology. 2003 Jul 22; 61(2):189-94. PMID: 12874397.
      View in: PubMed
    62. Wu YW, Hamrick SE, Miller SP, Haward MF, Lai MC, Callen PW, Barkovich AJ, Ferriero DM. Intraventricular hemorrhage in term neonates caused by sinovenous thrombosis. Ann Neurol. 2003 Jul; 54(1):123-6. PMID: 12838529.
      View in: PubMed
    63. Strauss DJ, Day SM, Shavelle RM, Wu YW. Remote symptomatic epilepsy: does seizure severity increase mortality? Neurology. 2003 Feb 11; 60(3):395-9. PMID: 12578917.
      View in: PubMed
    64. Day S, Strauss D, Shavelle R, Wu YW. Excess mortality in remote symptomatic epilepsy. J Insur Med. 2003; 35(3-4):155-60. PMID: 14971087.
      View in: PubMed
    65. Wu YW, Miller SP, Chin K, Collins AE, Lomeli SC, Chuang NA, Barkovich AJ, Ferriero DM. Multiple risk factors in neonatal sinovenous thrombosis. Neurology. 2002 Aug 13; 59(3):438-40. PMID: 12177381.
      View in: PubMed
    66. Wu YW. Systematic review of chorioamnionitis and cerebral palsy. Ment Retard Dev Disabil Res Rev. 2002; 8(1):25-9. PMID: 11921383.
      View in: PubMed
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