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Brandon Holmes, MD, PhD

Title(s)Resident, Neurology
SchoolSchool of Medicine
Address505 Parnassus Ave
San Francisco CA 94143
Phone415-353-2273
ORCID ORCID Icon0000-0002-1153-840X Additional info
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    Oberlin College, Oberlin, OhioBA05/2007Neuroscience
    Washington University in Saint Louis, Saint Louis, MOMD05/2017Medicine
    Washington University in Saint Louis, Saint Louis, MOPhD05/2017Neuroscience
    UCSF, San Francisco, CANeurology Residency
    UCSF, San Francisco, CAPostdoctoral Scholar, Wells Lab

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    R25 Postdoctoral Research Fellowship: Elucidating the Microglia Surfaceome
    NIH 2R25NS070680-11Jul 1, 2020 - Jun 30, 2023
    Tracking the Propagation of Misfolded Tau: A Study of Cellular Uptake and Traffic
    NIH F31NS079039Apr 1, 2012 - Mar 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An isolated ruptured spinal aneurysm presents with a thalamic Infarct: case report. BMC Neurol. 2021 Feb 03; 21(1):52. Tenorio A, Holmes BB, Abla AA, Amans M, Meisel K. PMID: 33535981.
      View in: PubMed   Mentions:    Fields:    
    2. A synthetic heparinoid blocks Tau aggregate cell uptake and amplification. J Biol Chem. 2020 03 06; 295(10):2974-2983. Stopschinski BE, Thomas TL, Nadji S, Darvish E, Fan L, Holmes BB, Modi AR, Finnell JG, Kashmer OM, Estill-Terpack S, Mirbaha H, Luu HS, Diamond MI. PMID: 31974166.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Adult-Onset Subacute Sclerosing Panencephalitis With a 30-Year Latent Period. Neurohospitalist. 2020 Apr; 10(2):127-132. Holmes BB, Conell-Price J, Kreple CJ, Ashraf D, Betjemann J, Rosendale N. PMID: 32373277.
      View in: PubMed   Mentions:
    4. Parkinson's disease and multiple system atrophy have distinct a-synuclein seed characteristics. J Biol Chem. 2019 01 18; 294(3):1045-1058. Yamasaki TR, Holmes BB, Furman JL, Dhavale DD, Su BW, Song ES, Cairns NJ, Kotzbauer PT, Diamond MI. PMID: 30478174.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    5. Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus a-synuclein and ß-amyloid aggregates. J Biol Chem. 2018 07 06; 293(27):10826-10840. Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI. PMID: 29752409.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    6. Vertebrobasilar Dolichoectasia Causing An Optic Tract Syndrome. J Neuroophthalmol. 2017 06; 37(2):179-181. Holmes BB, Green WC, Kung NH, Goebel JA, Van Stavern GP. PMID: 28350571.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Cellular Models for the Study of Prions. Cold Spring Harb Perspect Med. 2017 Feb 01; 7(2). Holmes BB, Diamond MI. PMID: 27815306.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    8. Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Sci Transl Med. 2017 01 25; 9(374). DeVos SL, Miller RL, Schoch KM, Holmes BB, Kebodeaux CS, Wegener AJ, Chen G, Shen T, Tran H, Nichols B, Zanardi TA, Kordasiewicz HB, Swayze EE, Bennett CF, Diamond MI, Miller TM. PMID: 28123067.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    9. Prions and Protein Assemblies that Convey Biological Information in Health and Disease. Neuron. 2016 Feb 03; 89(3):433-48. Sanders DW, Kaufman SK, Holmes BB, Diamond MI. PMID: 26844828.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    10. Heparan sulfate proteoglycans mediate Aß-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells. Mol Neurodegener. 2016 Jan 22; 11:9. Reynolds MR, Singh I, Azad TD, Holmes BB, Verghese PB, Dietrich HH, Diamond M, Bu G, Han BH, Zipfel GJ. PMID: 26801396.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    11. Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry. J Vis Exp. 2015 Dec 08; (106):e53205. Furman JL, Holmes BB, Diamond MI. PMID: 26710240.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    12. Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation. J Biol Chem. 2015 Jun 12; 290(24):14893-903. Mirbaha H, Holmes BB, Sanders DW, Bieschke J, Diamond MI. PMID: 25887395.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    13. Proteopathic tau seeding predicts tauopathy in vivo. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):E4376-85. Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI. PMID: 25261551.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
    14. Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target. J Biol Chem. 2014 Jul 18; 289(29):19855-61. Holmes BB, Diamond MI. PMID: 24860099.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    15. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):E3138-47. Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI. PMID: 23898162.
      View in: PubMed   Mentions: 228     Fields:    Translation:HumansAnimalsCells
    16. An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1. J Biol Chem. 2013 Mar 01; 288(9):6063-71. Zheng Z, Li A, Holmes BB, Marasa JC, Diamond MI. PMID: 23319588.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    17. Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear. Development. 2012 Dec; 139(24):4666-74. Bank LM, Bianchi LM, Ebisu F, Lerman-Sinkoff D, Smiley EC, Shen YC, Ramamurthy P, Thompson DL, Roth TM, Beck CR, Flynn M, Teller RS, Feng L, Llewellyn GN, Holmes B, Sharples C, Coutinho-Budd J, Linn SA, Chervenak AP, Dolan DF, Benson J, Kanicki A, Martin CA, Altschuler R, Koch AE, Koch AE, Jewett EM, Germiller JA, Barald KF. PMID: 23172918.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    18. Cellular mechanisms of protein aggregate propagation. Curr Opin Neurol. 2012 Dec; 25(6):721-6. Holmes BB, Diamond MI. PMID: 23108252.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    19. Amyotrophic lateral sclerosis and organ donation: is there risk of disease transmission? Ann Neurol. 2012 Dec; 72(6):832-6. Holmes BB, Diamond MI. PMID: 23280834.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    20. Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem. 2012 Jun 01; 287(23):19440-51. Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI. PMID: 22461630.
      View in: PubMed   Mentions: 183     Fields:    Translation:HumansCells
    21. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci. 2011 Sep 14; 31(37):13110-7. Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM. PMID: 21917794.
      View in: PubMed   Mentions: 123     Fields:    Translation:HumansAnimalsCells
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