Loading...

Brandon Holmes, MD, PhD

TitleResident Physician
InstitutionUniversity of California San Francisco
DepartmentNeurology
Address505 Parnassus Ave
San Francisco CA 94143
vCardDownload vCard

    Collapse Research 
    Collapse Research Activities and Funding
    Tracking the Propagation of Misfolded Tau: A Study of Cellular Uptake and Traffic
    NIH/NINDS F31NS079039Apr 1, 2012 - Mar 31, 2015
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI. Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau vs. a-synuclein and ß-amyloid aggregates. J Biol Chem. 2018 May 11. PMID: 29752409.
      View in: PubMed
    2. Holmes BB, Green WC, Kung NH, Goebel JA, Van Stavern GP. Vertebrobasilar Dolichoectasia Causing An Optic Tract Syndrome. J Neuroophthalmol. 2017 06; 37(2):179-181. PMID: 28350571.
      View in: PubMed
    3. Holmes BB, Diamond MI. Cellular Models for the Study of Prions. Cold Spring Harb Perspect Med. 2017 Feb 01; 7(2). PMID: 27815306.
      View in: PubMed
    4. DeVos SL, Miller RL, Schoch KM, Holmes BB, Kebodeaux CS, Wegener AJ, Chen G, Shen T, Tran H, Nichols B, Zanardi TA, Kordasiewicz HB, Swayze EE, Bennett CF, Diamond MI, Miller TM. Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Sci Transl Med. 2017 01 25; 9(374). PMID: 28123067.
      View in: PubMed
    5. Sanders DW, Kaufman SK, Holmes BB, Diamond MI. Prions and Protein Assemblies that Convey Biological Information in Health and Disease. Neuron. 2016 Feb 03; 89(3):433-48. PMID: 26844828; PMCID: PMC4748384 [Available on 02/03/17].
      View in: PubMed, PubMed Central
    6. Reynolds MR, Singh I, Azad TD, Holmes BB, Verghese PB, Dietrich HH, Diamond M, Bu G, Han BH, Zipfel GJ. Heparan sulfate proteoglycans mediate Aß-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells. Mol Neurodegener. 2016 Jan 22; 11:9. PMID: 26801396; PMCID: PMC4722750.
      View in: PubMed, PubMed Central
    7. Furman JL, Holmes BB, Diamond MI. Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry. J Vis Exp. 2015 Dec 08; (106):e53205. PMID: 26710240.
      View in: PubMed
    8. Mirbaha H, Holmes BB, Sanders DW, Bieschke J, Diamond MI. Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation. J Biol Chem. 2015 Jun 12; 290(24):14893-903. PMID: 25887395; PMCID: PMC4463437.
      View in: PubMed, PubMed Central
    9. Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI. Proteopathic tau seeding predicts tauopathy in vivo. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):E4376-85. PMID: 25261551; PMCID: PMC4205609.
      View in: PubMed, PubMed Central
    10. Holmes BB, Diamond MI. Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target. J Biol Chem. 2014 Jul 18; 289(29):19855-61. PMID: 24860099; PMCID: PMC4106306.
      View in: PubMed, PubMed Central
    11. Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):E3138-47. PMID: 23898162; PMCID: PMC3746848.
      View in: PubMed, PubMed Central
    12. Zheng Z, Li A, Holmes BB, Marasa JC, Diamond MI. An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1. J Biol Chem. 2013 Mar 01; 288(9):6063-71. PMID: 23319588; PMCID: PMC3585045.
      View in: PubMed, PubMed Central
    13. Bank LM, Bianchi LM, Ebisu F, Lerman-Sinkoff D, Smiley EC, Shen YC, Ramamurthy P, Thompson DL, Roth TM, Beck CR, Flynn M, Teller RS, Feng L, Llewellyn GN, Holmes B, Sharples C, Coutinho-Budd J, Linn SA, Chervenak AP, Dolan DF, Benson J, Kanicki A, Martin CA, Altschuler R, Koch AE, Koch AE, Jewett EM, Germiller JA, Barald KF. Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear. Development. 2012 Dec; 139(24):4666-74. PMID: 23172918; PMCID: PMC3509728.
      View in: PubMed, PubMed Central
    14. Holmes BB, Diamond MI. Cellular mechanisms of protein aggregate propagation. Curr Opin Neurol. 2012 Dec; 25(6):721-6. PMID: 23108252; PMCID: PMC3564233.
      View in: PubMed, PubMed Central
    15. Holmes BB, Diamond MI. Amyotrophic lateral sclerosis and organ donation: is there risk of disease transmission? Ann Neurol. 2012 Dec; 72(6):832-6. PMID: 23280834; PMCID: PMC3569489.
      View in: PubMed, PubMed Central
    16. Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI. Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem. 2012 Jun 01; 287(23):19440-51. PMID: 22461630; PMCID: PMC3365982.
      View in: PubMed, PubMed Central
    17. Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci. 2011 Sep 14; 31(37):13110-7. PMID: 21917794; PMCID: PMC4299126.
      View in: PubMed, PubMed Central
    Brandon's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (103) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (2) people
    _
    Related Authors
    People who share related concepts with this person.
    See all (60) people
    _
    ↑