Brandon Holmes, MD, PhD
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Title(s) | Resident, Neurology |
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School | School of Medicine |
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Phone | 415-353-2273 |
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vCard | Download vCard |
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Title(s) | UCSF Weill Institute for Neurosciences |
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Research Bibliographic
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Yamasaki TR, Holmes BB, Furman JL, Dhavale DD, Su BW, Song ES, Cairns NJ, Kotzbauer PT, Diamond MI. Parkinson's disease and multiple system atrophy have distinct a-synuclein seed characteristics. J Biol Chem. 2019 01 18; 294(3):1045-1058. PMID: 30478174.
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Stopschinski BE, Holmes BB, Miller GM, Manon VA, Vaquer-Alicea J, Prueitt WL, Hsieh-Wilson LC, Diamond MI. Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus a-synuclein and ß-amyloid aggregates. J Biol Chem. 2018 07 06; 293(27):10826-10840. PMID: 29752409.
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Holmes BB, Green WC, Kung NH, Goebel JA, Van Stavern GP. Vertebrobasilar Dolichoectasia Causing An Optic Tract Syndrome. J Neuroophthalmol. 2017 06; 37(2):179-181. PMID: 28350571.
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Holmes BB, Diamond MI. Cellular Models for the Study of Prions. Cold Spring Harb Perspect Med. 2017 Feb 01; 7(2). PMID: 27815306.
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DeVos SL, Miller RL, Schoch KM, Holmes BB, Kebodeaux CS, Wegener AJ, Chen G, Shen T, Tran H, Nichols B, Zanardi TA, Kordasiewicz HB, Swayze EE, Bennett CF, Diamond MI, Miller TM. Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Sci Transl Med. 2017 01 25; 9(374). PMID: 28123067.
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Sanders DW, Kaufman SK, Holmes BB, Diamond MI. Prions and Protein Assemblies that Convey Biological Information in Health and Disease. Neuron. 2016 Feb 03; 89(3):433-48. PMID: 26844828.
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Reynolds MR, Singh I, Azad TD, Holmes BB, Verghese PB, Dietrich HH, Diamond M, Bu G, Han BH, Zipfel GJ. Heparan sulfate proteoglycans mediate Aß-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells. Mol Neurodegener. 2016 Jan 22; 11:9. PMID: 26801396.
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Furman JL, Holmes BB, Diamond MI. Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry. J Vis Exp. 2015 Dec 08; (106):e53205. PMID: 26710240.
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Mirbaha H, Holmes BB, Sanders DW, Bieschke J, Diamond MI. Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation. J Biol Chem. 2015 Jun 12; 290(24):14893-903. PMID: 25887395.
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Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI. Proteopathic tau seeding predicts tauopathy in vivo. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):E4376-85. PMID: 25261551.
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Holmes BB, Diamond MI. Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target. J Biol Chem. 2014 Jul 18; 289(29):19855-61. PMID: 24860099.
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Holmes BB, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):E3138-47. PMID: 23898162.
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Zheng Z, Li A, Holmes BB, Marasa JC, Diamond MI. An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1. J Biol Chem. 2013 Mar 01; 288(9):6063-71. PMID: 23319588.
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Bank LM, Bianchi LM, Ebisu F, Lerman-Sinkoff D, Smiley EC, Shen YC, Ramamurthy P, Thompson DL, Roth TM, Beck CR, Flynn M, Teller RS, Feng L, Llewellyn GN, Holmes B, Sharples C, Coutinho-Budd J, Linn SA, Chervenak AP, Dolan DF, Benson J, Kanicki A, Martin CA, Altschuler R, Koch AE, Koch AE, Jewett EM, Germiller JA, Barald KF. Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear. Development. 2012 Dec; 139(24):4666-74. PMID: 23172918.
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Holmes BB, Diamond MI. Cellular mechanisms of protein aggregate propagation. Curr Opin Neurol. 2012 Dec; 25(6):721-6. PMID: 23108252.
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Holmes BB, Diamond MI. Amyotrophic lateral sclerosis and organ donation: is there risk of disease transmission? Ann Neurol. 2012 Dec; 72(6):832-6. PMID: 23280834.
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Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI. Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem. 2012 Jun 01; 287(23):19440-51. PMID: 22461630.
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Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci. 2011 Sep 14; 31(37):13110-7. PMID: 21917794.
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