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Brandon Holmes, MD, PhD

TitleResident Physician
SchoolUCSF School of Medicine
DepartmentNeurology
Address505 Parnassus Ave
San Francisco CA 94143
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    Collapse Research 
    Collapse Research Activities and Funding
    Tracking the Propagation of Misfolded Tau: A Study of Cellular Uptake and Traffic
    NIH/NINDS F31NS079039Apr 1, 2012 - Mar 31, 2015
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Holmes B, Green WC, Kung NH, Goebel JA, Van Stavern GP. Vertebrobasilar Dolichoectasia Causing An Optic Tract Syndrome. J Neuroophthalmol. 2017 Jun; 37(2):179-181. PMID: 28350571.
      View in: PubMed
    2. Holmes B, Diamond MI. Cellular Models for the Study of Prions. Cold Spring Harb Perspect Med. 2017 Feb 01; 7(2). PMID: 27815306.
      View in: PubMed
    3. DeVos SL, Miller RL, Schoch KM, Holmes B, Kebodeaux CS, Wegener AJ, Chen G, Shen T, Tran H, Nichols B, Zanardi TA, Kordasiewicz HB, Swayze EE, Bennett CF, Diamond MI, Miller TM. Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Sci Transl Med. 2017 Jan 25; 9(374). PMID: 28123067.
      View in: PubMed
    4. Sanders DW, Kaufman SK, Holmes B, Diamond MI. Prions and Protein Assemblies that Convey Biological Information in Health and Disease. Neuron. 2016 Feb 03; 89(3):433-48. PMID: 26844828; PMCID: PMC4748384 [Available on 02/03/17].
    5. Reynolds MR, Singh I, Azad TD, Holmes B, Verghese PB, Dietrich HH, Diamond M, Bu G, Han BH, Zipfel GJ. Heparan sulfate proteoglycans mediate Aß-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells. Mol Neurodegener. 2016 Jan 22; 11:9. PMID: 26801396; PMCID: PMC4722750.
    6. Furman JL, Holmes B, Diamond MI. Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry. J Vis Exp. 2015 Dec 08; (106):e53205. PMID: 26710240.
      View in: PubMed
    7. Mirbaha H, Holmes B, Sanders DW, Bieschke J, Diamond MI. Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation. J Biol Chem. 2015 Jun 12; 290(24):14893-903. PMID: 25887395; PMCID: PMC4463437.
    8. Holmes B, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI. Proteopathic tau seeding predicts tauopathy in vivo. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):E4376-85. PMID: 25261551; PMCID: PMC4205609.
    9. Holmes B, Diamond MI. Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target. J Biol Chem. 2014 Jul 18; 289(29):19855-61. PMID: 24860099; PMCID: PMC4106306.
    10. Holmes B, DeVos SL, Kfoury N, Li M, Jacks R, Yanamandra K, Ouidja MO, Brodsky FM, Marasa J, Bagchi DP, Kotzbauer PT, Miller TM, Papy-Garcia D, Diamond MI. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):E3138-47. PMID: 23898162; PMCID: PMC3746848.
    11. Zheng Z, Li A, Holmes B, Marasa JC, Diamond MI. An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1. J Biol Chem. 2013 Mar 01; 288(9):6063-71. PMID: 23319588; PMCID: PMC3585045.
    12. Holmes B, Diamond MI. Amyotrophic lateral sclerosis and organ donation: is there risk of disease transmission? Ann Neurol. 2012 Dec; 72(6):832-6. PMID: 23280834; PMCID: PMC3569489.
    13. Bank LM, Bianchi LM, Ebisu F, Lerman-Sinkoff D, Smiley EC, Shen YC, Ramamurthy P, Thompson DL, Roth TM, Beck CR, Flynn M, Teller RS, Feng L, Llewellyn GN, Holmes B, Sharples C, Coutinho-Budd J, Linn SA, Chervenak AP, Dolan DF, Benson J, Kanicki A, Martin CA, Altschuler R, Koch AE, Koch AE, Jewett EM, Germiller JA, Barald KF. Macrophage migration inhibitory factor acts as a neurotrophin in the developing inner ear. Development. 2012 Dec; 139(24):4666-74. PMID: 23172918; PMCID: PMC3509728.
    14. Holmes B, Diamond MI. Cellular mechanisms of protein aggregate propagation. Curr Opin Neurol. 2012 Dec; 25(6):721-6. PMID: 23108252; PMCID: PMC3564233.
    15. Kfoury N, Holmes B, Jiang H, Holtzman DM, Diamond MI. Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem. 2012 Jun 01; 287(23):19440-51. PMID: 22461630; PMCID: PMC3365982.
    16. Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes B, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci. 2011 Sep 14; 31(37):13110-7. PMID: 21917794; PMCID: PMC4299126.
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