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SARS-CoV-2 variants evolve convergent strategies to remodel the host response. Cell. 2023 10 12; 186(21):4597-4614.e26.
Bouhaddou M, Reuschl AK, Polacco BJ, Thorne LG, Ummadi MR, Ye C, Rosales R, Pelin A, Batra J, Jang GM, Xu J, Moen JM, Richards AL, Zhou Y, Harjai B, Stevenson E, Rojc A, Ragazzini R, Whelan MVX, Furnon W, De Lorenzo G, Cowton V, Syed AM, Ciling A, Deutsch N, Pirak D, Dowgier G, Mesner D, Turner JL, McGovern BL, Rodriguez ML, Leiva-Rebollo R, Dunham AS, Zhong X, Eckhardt M, Fossati A, Liotta NF, Kehrer T, Cupic A, Rutkowska M, Mena I, Aslam S, Hoffert A, Foussard H, Olwal CO, Huang W, Zwaka T, Pham J, Lyons M, Donohue L, Griffin A, Nugent R, Holden K, Deans R, Aviles P, Lopez-Martin JA, Jimeno JM, Obernier K, Fabius JM, Soucheray M, Hüttenhain R, Jungreis I, Kellis M, Echeverria I, Verba K, Bonfanti P, Beltrao P, Sharan R, Doudna JA, Martinez-Sobrido L, Patel AH, Palmarini M, Miorin L, White K, Swaney DL, Garcia-Sastre A, Jolly C, Zuliani-Alvarez L, Towers GJ, Krogan NJ. PMID: 37738970; PMCID: PMC10604369.
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PubMed Mentions:
9 Fields:
Translation:
HumansCellsPHPublic Health
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Next-generation proteomics for quantitative Jumbophage-bacteria interaction mapping. Nat Commun. 2023 08 24; 14(1):5156.
Fossati A, Mozumdar D, Kokontis C, Mèndez-Moran M, Nieweglowska E, Pelin A, Li Y, Guo B, Krogan NJ, Agard DA, Bondy-Denomy J, Swaney DL. PMID: 37620325; PMCID: PMC10449902.
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PubMed Mentions:
2 Fields:
Translation:
Cells
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Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies. Nat Commun. 2023 05 26; 14(1):3035.
Azad T, Rezaei R, Singaravelu R, Pelin A, Boulton S, Petryk J, Onsu KA, Martin NT, Hoskin V, Ghahremani M, Marotel M, Marius R, He X, Crupi MJF, Hoang HD, Nik-Akhtar A, Ahmadi M, Zamani NK, Golshani A, Alain T, Greer P, Ardolino M, Dickinson BC, Tai LH, Ilkow CS, Bell JC. PMID: 37236967; PMCID: PMC10213590.
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PubMed Mentions:
7 Fields:
Translation:
Cells
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Next-generation interaction proteomics for quantitative Jumbophage-bacteria interaction mapping. bioRxiv. 2023 Feb 23.
Fossati A, Mozumdar D, Kokontis C, Mèndez-Moran M, Nieweglowska E, Pelin A, Li Y, Guo B, Krogan NJ, Agard DA, Bondy-Denomy J, Swaney DL. PMID: 36711836; PMCID: PMC9882154.
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CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX. Front Immunol. 2022; 13:1050250.
Whelan JT, Singaravelu R, Wang F, Pelin A, Tamming LA, Pugliese G, Martin NT, Crupi MJF, Petryk J, Austin B, He X, Marius R, Duong J, Jones C, Fekete EEF, Alluqmani N, Chen A, Boulton S, Huh MS, Tang MY, Taha Z, Scut E, Diallo JS, Azad T, Lichty BD, Ilkow CS, Bell JC. PMID: 36713447; PMCID: PMC9880309.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Oncolytic virus driven T-cell-based combination immunotherapy platform for colorectal cancer. Front Immunol. 2022; 13:1029269.
Crupi MJF, Taha Z, Janssen TJA, Petryk J, Boulton S, Alluqmani N, Jirovec A, Kassas O, Khan ST, Vallati S, Lee E, Huang BZ, Huh M, Pikor L, He X, Marius R, Austin B, Duong J, Pelin A, Neault S, Azad T, Breitbach CJ, Stojdl DF, Burgess MF, McComb S, Auer R, Diallo JS, Ilkow CS, Bell JC. PMID: 36405739; PMCID: PMC9670134.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy. Nat Commun. 2022 04 07; 13(1):1898.
Wedge ME, Jennings VA, Crupi MJF, Poutou J, Jamieson T, Pelin A, Pugliese G, de Souza CT, Petryk J, Laight BJ, Boileau M, Taha Z, Alluqmani N, McKay HE, Pikor L, Khan ST, Azad T, Rezaei R, Austin B, He X, Mansfield D, Rose E, Brown EEF, Crawford N, Alkayyal A, Surendran A, Singaravelu R, Roy DG, Migneco G, McSweeney B, Cottee ML, Jacobus EJ, Keller BA, Yamaguchi TN, Boutros PC, Geoffrion M, Rayner KJ, Chatterjee A, Auer RC, Diallo JS, Gibbings D, tenOever BR, Melcher A, Bell JC, Ilkow CS. PMID: 35393414; PMCID: PMC8990073.
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PubMed Mentions:
14 Fields:
Translation:
HumansCells
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Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2. Nature. 2022 Apr; 604(7905):E14.
Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, Hiatt J, Rosales R, McGovern BL, Jahun A, Fabius JM, White K, Goodfellow IG, Takeuchi Y, Bonfanti P, Shokat K, Jura N, Verba K, Noursadeghi M, Beltrao P, Kellis M, Swaney DL, García-Sastre A, Jolly C, Towers GJ, Krogan NJ. PMID: 35332335; PMCID: PMC8944406.
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PubMed Mentions:
1 Fields:
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Evolution of enhanced innate immune evasion by SARS-CoV-2. Nature. 2022 02; 602(7897):487-495.
Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Hosmillo M, Fossati A, Ragazzini R, Jungreis I, Ummadi M, Rojc A, Turner J, Bischof ML, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, Hiatt J, Rosales R, McGovern BL, Jahun A, Fabius JM, White K, Goodfellow IG, Takeuchi Y, Bonfanti P, Shokat K, Jura N, Verba K, Noursadeghi M, Beltrao P, Kellis M, Swaney DL, García-Sastre A, Jolly C, Towers GJ, Krogan NJ. PMID: 34942634; PMCID: PMC8850198.
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PubMed Mentions:
166 Fields:
Translation:
HumansCells
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Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection. Mol Ther. 2022 05 04; 30(5):1885-1896.
Boulton S, Poutou J, Martin NT, Azad T, Singaravelu R, Crupi MJF, Jamieson T, He X, Marius R, Petryk J, Tanese de Souza C, Austin B, Taha Z, Whelan J, Khan ST, Pelin A, Rezaei R, Surendran A, Tucker S, Fekete EEF, Dave J, Diallo JS, Auer R, Angel JB, Cameron DW, Cailhier JF, Lapointe R, Potts K, Mahoney DJ, Bell JC, Ilkow CS. PMID: 34687845; PMCID: PMC8527104.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant. bioRxiv. 2021 Jun 07.
Thorne LG, Bouhaddou M, Reuschl AK, Zuliani-Alvarez L, Polacco B, Pelin A, Batra J, Whelan MVX, Ummadi M, Rojc A, Turner J, Obernier K, Braberg H, Soucheray M, Richards A, Chen KH, Harjai B, Memon D, Hosmillo M, Hiatt J, Jahun A, Goodfellow IG, Fabius JM, Shokat K, Jura N, Verba K, Noursadeghi M, Beltrao P, Swaney DL, Garcia-Sastre A, Jolly C, Towers GJ, Krogan NJ. PMID: 34127972; PMCID: PMC8202424.
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PubMed Mentions:
8
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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Res Sq. 2021 May 19.
Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34031651; PMCID: PMC8142659.
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PubMed Mentions:
1
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CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11.
Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34013269; PMCID: PMC8132225.
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PubMed Mentions:
4
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Characterization of Critical Determinants of ACE2-SARS CoV-2 RBD Interaction. Int J Mol Sci. 2021 Feb 25; 22(5).
Brown EEF, Rezaei R, Jamieson TR, Dave J, Martin NT, Singaravelu R, Crupi MJF, Boulton S, Tucker S, Duong J, Poutou J, Pelin A, Yasavoli-Sharahi H, Taha Z, Arulanandam R, Surendran A, Ghahremani M, Austin B, Matar C, Diallo JS, Bell JC, Ilkow CS, Azad T. PMID: 33668756; PMCID: PMC7956771.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry. Mol Ther. 2021 06 02; 29(6):1984-2000.
Azad T, Singaravelu R, Taha Z, Jamieson TR, Boulton S, Crupi MJF, Martin NT, Fekete EEF, Poutou J, Ghahremani M, Pelin A, Nouri K, Rezaei R, Marshall CB, Enomoto M, Arulanandam R, Alluqmani N, Samson R, Gingras AC, Cameron DW, Greer PA, Ilkow CS, Diallo JS, Bell JC. PMID: 33578036; PMCID: PMC7872859.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Emerging translation strategies during virus-host interaction. Wiley Interdiscip Rev RNA. 2021 01; 12(1):e1619.
Hoang HD, Neault S, Pelin A, Alain T. PMID: 32757266; PMCID: PMC7435527.
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PubMed Mentions:
13 Fields:
Translation:
Cells
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Engineering vaccinia virus as an immunotherapeutic battleship to overcome tumor heterogeneity. Expert Opin Biol Ther. 2020 09; 20(9):1083-1097.
Pelin A, Boulton S, Tamming LA, Bell JC, Singaravelu R. PMID: 32297534.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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Deletion of Apoptosis Inhibitor F1L in Vaccinia Virus Increases Safety and Oncolysis for Cancer Therapy. Mol Ther Oncolytics. 2019 Sep 27; 14:246-252.
Pelin A, Foloppe J, Petryk J, Singaravelu R, Hussein M, Gossart F, Jennings VA, Stubbert LJ, Foster M, Storbeck C, Postigo A, Scut E, Laight B, Way M, Erbs P, Le Boeuf F, Bell JC. PMID: 31428674; PMCID: PMC6695278.
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PubMed Mentions:
15
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Correction: Single nucleus sequencing reveals evidence of inter-nucleus recombination in arbuscular mycorrhizal fungi. Elife. 2019 Mar 21; 8.
Chen EC, Mathieu S, Sedzielewska-Toro K, Peart M, Pelin A, Ndikumana S, Ropars J, Dreissig S, Fuchs J, Brachmann A, Corradi N. PMID: 30895927; PMCID: PMC6428567.
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PubMed Mentions:
1 Fields:
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Comparative genomics of Rhizophagus irregularis, R. cerebriforme, R. diaphanus and Gigaspora rosea highlights specific genetic features in Glomeromycotina. New Phytol. 2019 05; 222(3):1584-1598.
Morin E, Miyauchi S, San Clemente H, Chen ECH, Pelin A, de la Providencia I, Ndikumana S, Beaudet D, Hainaut M, Drula E, Kuo A, Tang N, Roy S, Viala J, Henrissat B, Grigoriev IV, Corradi N, Roux C, Martin FM. PMID: 30636349.
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PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Single nucleus sequencing reveals evidence of inter-nucleus recombination in arbuscular mycorrhizal fungi. Elife. 2018 12 05; 7.
Chen EC, Mathieu S, Hoffrichter A, Sedzielewska-Toro K, Peart M, Pelin A, Ndikumana S, Ropars J, Dreissig S, Fuchs J, Brachmann A, Corradi N. PMID: 30516133; PMCID: PMC6281316.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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Leveraging single-cell genomics to expand the fungal tree of life. Nat Microbiol. 2018 12; 3(12):1417-1428.
Ahrendt SR, Quandt CA, Ciobanu D, Clum A, Salamov A, Andreopoulos B, Cheng JF, Woyke T, Pelin A, Henrissat B, Reynolds NK, Benny GL, Smith ME, James TY, Grigoriev IV. PMID: 30297742; PMCID: PMC6784888.
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PubMed Mentions:
46 Fields:
Translation:
Animals
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Genetic and Genome Analyses Reveal Genetically Distinct Populations of the Bee Pathogen Nosema ceranae from Thailand. Microb Ecol. 2019 May; 77(4):877-889.
Peters MJ, Suwannapong G, Pelin A, Corradi N. PMID: 30288544.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis. PLoS Pathog. 2018 08; 14(8):e1007264.
Zakaria C, Sean P, Hoang HD, Leroux LP, Watson M, Workenhe ST, Hearnden J, Pearl D, Truong VT, Robichaud N, Yanagiya A, Tahmasebi S, Jafarnejad SM, Jia JJ, Pelin A, Diallo JS, Le Boeuf F, Bell JC, Mossman KL, Graber TE, Jaramillo M, Sonenberg N, Alain T. PMID: 30138450; PMCID: PMC6124814.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Use of Precision-Cut Lung Slices as an Ex Vivo Tool for Evaluating Viruses and Viral Vectors for Gene and Oncolytic Therapy. Mol Ther Methods Clin Dev. 2018 Sep 21; 10:245-256.
Rosales Gerpe MC, van Vloten JP, Santry LA, de Jong J, Mould RC, Pelin A, Bell JC, Bridle BW, Wootton SK. PMID: 30112421; PMCID: PMC6092314.
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PubMed Mentions:
17
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Enhanced susceptibility of cancer cells to oncolytic rhabdo-virotherapy by expression of Nodamura virus protein B2 as a suppressor of RNA interference. J Immunother Cancer. 2018 06 19; 6(1):62.
Bastin D, Aitken AS, Pelin A, Pikor LA, Crupi MJF, Huh MS, Bourgeois-Daigneault MC, Bell JC, Ilkow CS. PMID: 29921327; PMCID: PMC6008949.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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The importance of imaging strategies for pre-clinical and clinical in vivo distribution of oncolytic viruses. Oncolytic Virother. 2017; 7:25-35.
Pelin A, Wang J, Bell J, Le Boeuf F. PMID: 29637059; PMCID: PMC5880516.
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PubMed Mentions:
5
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Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy. Sci Transl Med. 2018 01 03; 10(422).
Bourgeois-Daigneault MC, Roy DG, Aitken AS, El Sayes N, Martin NT, Varette O, Falls T, St-Germain LE, Pelin A, Lichty BD, Stojdl DF, Ungerechts G, Diallo JS, Bell JC. PMID: 29298865.
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PubMed Mentions:
152 Fields:
Translation:
HumansCells
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Secretoneurin A regulates neurogenic and inflammatory transcriptional networks in goldfish (Carassius auratus) radial glia. Sci Rep. 2017 11 02; 7(1):14930.
Da Fonte DF, Martyniuk CJ, Xing L, Pelin A, Corradi N, Hu W, Trudeau VL. PMID: 29097753; PMCID: PMC5668316.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Corrigendum: A proteinaceous organic matrix regulates carbonate mineral production in the marine teleost intestine. Sci Rep. 2017 06 19; 7:46844.
Schauer KL, LeMoine CMR, Pelin A, Corradi N, McDonald MD, Warren WC, Grosell M. PMID: 28627517; PMCID: PMC5474954.
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PubMed Mentions: Fields:
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A proteinaceous organic matrix regulates carbonate mineral production in the marine teleost intestine. Sci Rep. 2016 10 03; 6:34494.
Schauer KL, LeMoine CM, Pelin A, Corradi N, Warren WC, Grosell M, McDonald MD. PMID: 27694946; PMCID: PMC5046086.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Combination of Paclitaxel and MG1 oncolytic virus as a successful strategy for breast cancer treatment. Breast Cancer Res. 2016 08 08; 18(1):83.
Bourgeois-Daigneault MC, St-Germain LE, Roy DG, Pelin A, Aitken AS, Arulanandam R, Falls T, Garcia V, Diallo JS, Bell JC. PMID: 27503504; PMCID: PMC4977613.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Genome Analysis of Pseudoloma neurophilia: A Microsporidian Parasite of Zebrafish (Danio rerio). J Eukaryot Microbiol. 2017 01; 64(1):18-30.
Ndikumana S, Pelin A, Williot A, Sanders JL, Kent M, Corradi N. PMID: 27230544; PMCID: PMC5124540.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Evidence for the sexual origin of heterokaryosis in arbuscular mycorrhizal fungi. Nat Microbiol. 2016 03 21; 1(6):16033.
Ropars J, Toro KS, Noel J, Pelin A, Charron P, Farinelli L, Marton T, Krüger M, Fuchs J, Brachmann A, Corradi N. PMID: 27572831.
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PubMed Mentions:
39 Fields:
Translation:
Animals
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Genome analyses suggest the presence of polyploidy and recent human-driven expansions in eight global populations of the honeybee pathogen Nosema ceranae. Environ Microbiol. 2015 Nov; 17(11):4443-58.
Pelin A, Selman M, Aris-Brosou S, Farinelli L, Corradi N. PMID: 25914091.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Morphology and phylogeny of Agmasoma penaei (Microsporidia) from the type host, Litopenaeus setiferus, and the type locality, Louisiana, USA. Int J Parasitol. 2015 Jan; 45(1):1-16.
Sokolova Y, Pelin A, Hawke J, Corradi N. PMID: 25449947.
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PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Microsporidian genomes harbor a diverse array of transposable elements that demonstrate an ancestry of horizontal exchange with metazoans. Genome Biol Evol. 2014 Aug 28; 6(9):2289-300.
Parisot N, Pelin A, Gasc C, Polonais V, Belkorchia A, Panek J, El Alaoui H, Biron DG, Brasset E, Vaury C, Peyret P, Corradi N, Peyretaillade É, Lerat E. PMID: 25172905; PMCID: PMC4202319.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Shared signatures of parasitism and phylogenomics unite Cryptomycota and microsporidia. Curr Biol. 2013 Aug 19; 23(16):1548-53.
James TY, Pelin A, Bonen L, Ahrendt S, Sain D, Corradi N, Stajich JE. PMID: 23932404.
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PubMed Mentions:
137 Fields:
Translation:
AnimalsCells
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The mitochondrial genome of the arbuscular mycorrhizal fungus Gigaspora margarita reveals two unsuspected trans-splicing events of group I introns. New Phytol. 2012 May; 194(3):836-845.
Pelin A, Pombert JF, Salvioli A, Bonen L, Bonfante P, Corradi N. PMID: 22320438.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells