Un Seng Chio, PhD

Title(s)Specialist, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th Street, #S474
San Francisco CA 94158
Phone415-514-9708
PronounsHe/Him/His
ORCID ORCID Icon0000-0002-5295-2690 Additional info
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    Collapse Biography 
    Collapse Education and Training
    CaltechPhD01/2019Chemistry (Biochemistry)
    Cornell UniversityB.A.05/2012Chemistry and Biology

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular mechanisms of the ACF chromatin remodeling complex
    NIH F32GM137463Apr 1, 2020 - Mar 31, 2023
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. ATP-dependent remodeling of chromatin condensates uncovers distinct mesoscale effects of two remodelers. bioRxiv. 2024 Sep 10. Moore C, Wong E, Kaur U, Chio US, Zhou Z, Ostrowski M, Wu K, Irkliyenko I, Wang S, Ramani V, Narlikar GJ. PMID: 39314305; PMCID: PMC11418981.
      View in: PubMed   Mentions:
    2. HMGB1 restores a dynamic chromatin environment in the presence of linker histone by deforming nucleosomal DNA. bioRxiv. 2024 Aug 24. Saunders HS, Chio US, Moore CM, Ramani V, Cheng Y, Narlikar GJ. PMID: 39229246; PMCID: PMC11370580.
      View in: PubMed   Mentions:
    3. Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun. 2024 Mar 12; 15(1):2225. Chio US, Palovcak E, Smith AAA, Autzen H, Muñoz EN, Yu Z, Wang F, Agard DA, Armache JP, Narlikar GJ, Cheng Y. PMID: 38472177; PMCID: PMC10933330.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    4. Nucleosome density shapes kilobase-scale regulation by a mammalian chromatin remodeler. Nat Struct Mol Biol. 2023 10; 30(10):1571-1581. Abdulhay NJ, Hsieh LJ, McNally CP, Ostrowski MS, Moore CM, Ketavarapu M, Kasinathan S, Nanda AS, Wu K, Chio US, Zhou Z, Goodarzi H, Narlikar GJ, Ramani V. PMID: 37696956; PMCID: PMC10584690.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    5. Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility. Science. 2023 07 21; 381(6655):319-324. Wu H, Muñoz EN, Hsieh LJ, Chio US, Gourdet MA, Narlikar GJ, Cheng Y. PMID: 37384669; PMCID: PMC10480058.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    6. Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. bioRxiv. 2023 Jun 20. Chio US, Palovcak E, Autzen AAA, Autzen HE, Muñoz EN, Yu Z, Wang F, Agard DA, Armache JP, Narlikar GJ, Cheng Y. PMID: 37546986; PMCID: PMC10402172.
      View in: PubMed   Mentions:
    7. Dodecamer assembly of a metazoan AAA+ chaperone couples substrate extraction to refolding. Sci Adv. 2023 05 10; 9(19):eadf5336. Gupta A, Lentzsch AM, Siegel A, Yu Z, Chio US, Cheng Y, Shan SO. PMID: 37163603; PMCID: PMC10171807.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Cryo-EM structure of the human Sirtuin 6-nucleosome complex. Sci Adv. 2023 04 14; 9(15):eadf7586. Chio US, Rechiche O, Bryll AR, Zhu J, Leith EM, Feldman JL, Peterson CL, Tan S, Armache JP. PMID: 37058572; PMCID: PMC10104460.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps. Structure. 2023 03 02; 31(3):253-264.e6. Remesh SG, Merz GE, Brilot AF, Chio US, Rizo AN, Pospiech TH, Lui I, Laurie MT, Glasgow J, Le CQ, Zhang Y, Diwanji D, Hernandez E, Lopez J, Mehmood H, Pawar KI, Pourmal S, Smith AM, Zhou F, QCRG Structural Biology Consortium, DeRisi J, Kortemme T, Rosenberg OS, Glasgow A, Leung KK, Wells JA, Verba KA. PMID: 36805129; PMCID: PMC9936628.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    10. Subunit cooperation in the Get1/2 receptor promotes tail-anchored membrane protein insertion. J Cell Biol. 2021 11 01; 220(11). Chio US, Liu Y, Chung S, Shim WJ, Chandrasekar S, Weiss S, Shan SO. PMID: 34614151; PMCID: PMC8530227.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    11. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Res Sq. 2021 May 19. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34031651; PMCID: PMC8142659.
      View in: PubMed   Mentions: 2  
    12. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. PMID: 34013269; PMCID: PMC8132225.
      View in: PubMed   Mentions: 4  
    13. An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 2020 12 18; 370(6523):1473-1479. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. PMID: 33154106; PMCID: PMC7857409.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansAnimalsCells
    14. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science. 2020 12 04; 370(6521). Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbølle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, et al. PMID: 33060197; PMCID: PMC7808408.
      View in: PubMed   Mentions: 377     Fields:    Translation:HumansCells
    15. A Chaperone Lid Ensures Efficient and Privileged Client Transfer during Tail-Anchored Protein Targeting. Cell Rep. 2019 01 02; 26(1):37-44.e7. Chio US, Chung S, Weiss S, Shan SO. PMID: 30605684; PMCID: PMC6689467.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    16. In vitro Assays for Targeting and Insertion of Tail-Anchored Proteins Into the ER Membrane. Curr Protoc Cell Biol. 2018 12; 81(1):e63. Cho H, Chio US, Shan SO. PMID: 30253068; PMCID: PMC6263799.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    17. Mechanisms of Tail-Anchored Membrane Protein Targeting and Insertion. Annu Rev Cell Dev Biol. 2017 10 06; 33:417-438. Chio US, Cho H, Shan SO. PMID: 28992441; PMCID: PMC6343671.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    18. A protean clamp guides membrane targeting of tail-anchored proteins. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8585-E8594. Chio US, Chung S, Weiss S, Shan SO. PMID: 28973888; PMCID: PMC5642712.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    19. Multiple selection filters ensure accurate tail-anchored membrane protein targeting. Elife. 2016 12 07; 5. Rao M, Okreglak V, Chio US, Cho H, Walter P, Shan SO. PMID: 27925580; PMCID: PMC5214336.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    20. Differential gradients of interaction affinities drive efficient targeting and recycling in the GET pathway. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):E4929-35. Rome ME, Chio US, Rao M, Gristick H, Shan SO. PMID: 25368153; PMCID: PMC4246279.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
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