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Martin McMahon, PhD

Title(s)Professor In Residence, HDF Comprehensive Cancer Ctr
SchoolSchool of Medicine
AddressLocation Required
Varies CA 00000
Phone801-213-5790
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    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoPostdoctoral StudiesGraduate Division

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting Oncogenic BRAF And PI3'-Kinase Signaling For Melanoma Therapy
    NIH/NCI R01CA176839Apr 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Studying the initiation, progression and therapy of lung cancer in mouse models
    NIH/NCI R01CA131261Apr 1, 2009 - Feb 28, 2015
    Role: Principal Investigator
    Regulation of apoptosis by mutationally activated B-Raf
    NIH/NCI R01CA108972Apr 1, 2005 - Nov 28, 2010
    Role: Principal Investigator
    Cancer Center Support Grant
    NIH/NCI P30CA082103Aug 5, 1999 - Sep 29, 2012
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chloroquine sensitizes GNAQ/11-mutated melanoma to MEK1/2 inhibition. Clin Cancer Res. 2020 Sep 15. Truong A, Yoo JH, Scherzer M, Sanchez JMS, Dale KJ, Kinsey CG, Richards JR, Shin D, Ghazi P, Onken MD, Blumer KJ, Odelberg SJ, McMahon M. PMID: 32933997.
      View in: PubMed   Mentions:    Fields:    
    2. Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer. Cell Rep. 2020 Aug 04; 32(5):107994. Vaishnavi A, Scherzer MT, Kinsey CG, Parkman GL, Truong A, Ghazi P, Schuman S, Battistone B, Garrido-Laguna I, McMahon M. PMID: 32755586.
      View in: PubMed   Mentions:    Fields:    
    3. RAC1mutation is not a predictive biomarker for PI3'-kinase-ß-selective pathway-targeted therapy. Pigment Cell Melanoma Res. 2020 09; 33(5):719-730. Foth M, Parkman G, Battistone B, McMahon M. PMID: 32406574.
      View in: PubMed   Mentions:    Fields:    
    4. Mutationally-activated PI3'-kinase-a promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase. Elife. 2019 08 27; 8. van Veen JE, Scherzer M, Boshuizen J, Chu M, Liu A, Landman A, Green S, Trejo C, McMahon M. PMID: 31452510.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis. Mol Cancer Res. 2019 09; 17(9):1787-1800. Kircher DA, Trombetti KA, Silvis MR, Parkman GL, Fischer GM, Angel SN, Stehn CM, Strain SC, Grossmann AH, Duffy KL, Boucher KM, McMahon M, Davies MA, Mendoza MC, VanBrocklin MW, Holmen SL. PMID: 31138602.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Publisher Correction: Protective autophagy elicited by RAF?MEK?ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nat Med. 2019 May; 25(5):861. Kinsey CG, Camolotto SA, Boespflug AM, Guillen KP, Foth M, Truong A, Schuman SS, Shea JE, Seipp MT, Yap JT, Burrell LD, Lum DH, Whisenant JR, Gilcrease GW, Cavalieri CC, Rehbein KM, Cutler SL, Affolter KE, Welm AL, Welm BE, Scaife CL, Snyder EL, McMahon M. PMID: 30918364.
      View in: PubMed   Mentions: 2     Fields:    
    7. Protective autophagy elicited by RAF?MEK?ERK inhibition suggests a treatment strategy for RAS-driven cancers. Nat Med. 2019 04; 25(4):620-627. Kinsey CG, Camolotto SA, Boespflug AM, Guillen KP, Foth M, Truong A, Schuman SS, Shea JE, Seipp MT, Yap JT, Burrell LD, Lum DH, Whisenant JR, Gilcrease GW, Cavalieri CC, Rehbein KM, Cutler SL, Affolter KE, Welm AL, Welm BE, Scaife CL, Snyder EL, McMahon M. PMID: 30833748.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    8. PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation. Pigment Cell Melanoma Res. 2017 05; 30(3):353-367. Silva JM, Deuker MM, Baguley BC, McMahon M. PMID: 28233937.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. BRAFV600E cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis. Elife. 2017 01 10; 6. Sakamoto N, Feng Y, Stolfi C, Kurosu Y, Green M, Lin J, Green ME, Sentani K, Yasui W, McMahon M, Hardiman KM, Spence JR, Horita N, Greenson JK, Kuick R, Cho KR, Fearon ER. PMID: 28072391.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    10. Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model. Oncotarget. 2016 Nov 15; 7(46):75839-75853. Grossauer S, Koeck K, Murphy NE, Meyers ID, Daynac M, Truffaux N, Truong AY, Nicolaides TP, McMahon M, Berger MS, Phillips JJ, James CD, Petritsch CK. PMID: 27713119.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    11. P2A-Fluorophore Tagging of BRAF Tightly Links Expression to Fluorescence In Vivo. PLoS One. 2016; 11(6):e0157661. van Veen JE, Pringle DR, McMahon M. PMID: 27348307.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. The state of melanoma: challenges and opportunities. Pigment Cell Melanoma Res. 2016 07; 29(4):404-16. Merlino G, Herlyn M, Fisher DE, Bastian BC, Flaherty KT, Davies MA, Wargo JA, Curiel-Lewandrowski C, Weber MJ, Leachman SA, Soengas MS, McMahon M, Harbour JW, Swetter SM, Aplin AE, Atkins MB, Bosenberg MW, Dummer R, Gershenwald JE, Halpern AC, Herlyn D, Karakousis GC, Kirkwood JM, Krauthammer M, Lo RS, Long GV, McArthur G, Ribas A, Schuchter L, Sosman JA, Smalley KS, Steeg P, Thomas NE, Tsao H, Tueting T, Weeraratna A, Xu G, Lomax R, Martin A, Silverstein S, Turnham T, Ronai ZA. PMID: 27087480.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    13. PIK3CA(H1047R) Accelerates and Enhances KRAS(G12D)-Driven Lung Tumorigenesis. Cancer Res. 2015 Dec 15; 75(24):5378-91. Green S, Trejo CL, McMahon M. PMID: 26567140.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. AKT1 Activation Promotes Development of Melanoma Metastases. Cell Rep. 2015 Nov 03; 13(5):898-905. Cho JH, Robinson JP, Arave RA, Burnett WJ, Kircher DA, Chen G, Davies MA, Grossmann AH, VanBrocklin MW, McMahon M, Holmen SL. PMID: 26565903.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    15. Intermittent dosing in melanoma. Clin Adv Hematol Oncol. 2015 Jun; 13(6):348-50. McMahon M. PMID: 26352888.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis. Cancer Res. 2015 Aug 01; 75(15):3167-80. Shai A, Dankort D, Juan J, Green S, McMahon M. PMID: 26001956.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    17. Rational targeting of BRAF and PI3-Kinase signaling for melanoma therapy. Mol Cell Oncol. 2016 May; 3(3):e1033095. Deuker MM, McMahon M. PMID: 27314067.
      View in: PubMed   Mentions:
    18. Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma. Nat Genet. 2015 May; 47(5):486-95. Mann MB, Black MA, Jones DJ, Ward JM, Yew CC, Newberg JY, Dupuy AJ, Rust AG, Bosenberg MW, McMahon M, Print CG, Copeland NG, Jenkins NA. PMID: 25848750.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    19. The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Nat Genet. 2015 Mar; 47(3):250-6. Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, Asthana S, Neel D, Yan JJ, Lu X, Pham L, Wang MM, Karachaliou N, Cao MG, Manzano JL, Ramirez JL, Torres JM, Buttitta F, Rudin CM, Collisson EA, Algazi A, Robinson E, Osman I, Muñoz-Couselo E, Cortes J, Frederick DT, Cooper ZA, McMahon M, Marchetti A, Rosell R, Flaherty KT, Wargo JA, Bivona TG. PMID: 25665005.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    20. mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation. Cancer Cell. 2015 Jan 12; 27(1):41-56. Damsky W, Micevic G, Meeth K, Muthusamy V, Curley DP, Santhanakrishnan M, Erdelyi I, Platt JT, Huang L, Theodosakis N, Zaidi MR, Tighe S, Davies MA, Dankort D, McMahon M, Merlino G, Bardeesy N, Bosenberg M. PMID: 25584893.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    21. PI3'-kinase inhibition forestalls the onset of MEK1/2 inhibitor resistance in BRAF-mutated melanoma. Cancer Discov. 2015 Feb; 5(2):143-53. Deuker MM, Marsh Durban V, Phillips WA, McMahon M. PMID: 25472943.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    22. Targeting RAF kinases for cancer therapy: BRAF-mutated melanoma and beyond. Nat Rev Cancer. 2014 Jul; 14(7):455-67. Holderfield M, Deuker MM, McCormick F, McMahon M. PMID: 24957944.
      View in: PubMed   Mentions: 191     Fields:    Translation:HumansAnimals
    23. Cancer biology: Enzyme meets a surprise target. Nature. 2014 Jun 12; 510(7504):225-6. Deuker MM, McMahon M. PMID: 24847879.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    24. Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunol Res. 2014 Jul; 2(7):643-54. Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, Lo JA, Hodi FS, Freeman GJ, Bosenberg MW, McMahon M, Flaherty KT, Fisher DE, Sharpe AH, Wargo JA. PMID: 24903021.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    25. Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis. Mol Cancer Res. 2014 Jul; 12(7):979-86. Charles RP, Silva J, Iezza G, Phillips WA, McMahon M. PMID: 24770869.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    26. Isolation and molecular characterization of circulating melanoma cells. Cell Rep. 2014 May 08; 7(3):645-53. Luo X, Mitra D, Sullivan RJ, Wittner BS, Kimura AM, Pan S, Hoang MP, Brannigan BW, Lawrence DP, Flaherty KT, Sequist LV, McMahon M, Bosenberg MW, Stott SL, Ting DT, Ramaswamy S, Toner M, Fisher DE, Maheswaran S, Haber DA. PMID: 24746818.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    27. p53 constrains progression to anaplastic thyroid carcinoma in a Braf-mutant mouse model of papillary thyroid cancer. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):E1600-9. McFadden DG, Vernon A, Santiago PM, Martinez-McFaline R, Bhutkar A, Crowley DM, McMahon M, Sadow PM, Jacks T. PMID: 24711431.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    28. Diminished WNT -> ß-catenin -> c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors. Genes Dev. 2014 Mar 15; 28(6):561-75. Juan J, Muraguchi T, Iezza G, Sears RC, McMahon M. PMID: 24589553.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    29. The fastest Western in town: a contemporary twist on the classic Western blot analysis. J Vis Exp. 2014 Feb 05; (84):e51149. Silva JM, McMahon M. PMID: 24561642.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    30. BRAFV600E cooperates with PI3K signaling, independent of AKT, to regulate melanoma cell proliferation. Mol Cancer Res. 2014 Mar; 12(3):447-63. Silva JM, Bulman C, McMahon M. PMID: 24425783.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    31. Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma. J Clin Invest. 2013 Dec; 123(12):5104-18. Marsh Durban V, Deuker MM, Bosenberg MW, Phillips W, McMahon M. PMID: 24200692.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    32. Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720. Mol Cancer Res. 2013 Dec; 11(12):1530-41. Kamata T, Dankort D, Kang J, Giblett S, Pritchard CA, McMahon M, Leavitt AD. PMID: 24152792.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    33. Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18226-31. Yuan P, Ito K, Perez-Lorenzo R, Del Guzzo C, Lee JH, Shen CH, Bosenberg MW, McMahon M, Cantley LC, Zheng B. PMID: 24145418.
      View in: PubMed   Mentions: 80     Fields:    Translation:Animals
    34. Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Hum Mol Genet. 2014 Feb 01; 23(3):682-92. Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD. PMID: 24057668.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    35. Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression. Cancer Res. 2013 Nov 01; 73(21):6448-61. Trejo CL, Green S, Marsh V, Collisson EA, Iezza G, Phillips WA, McMahon M. PMID: 24019382.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    36. Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discov. 2013 Nov; 3(11):1272-85. Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E. PMID: 23965987.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    37. Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. Nature. 2013 Feb 14; 494(7436):251-5. Das Thakur M, Salangsang F, Landman AS, Sellers WR, Pryer NK, Levesque MP, Dummer R, McMahon M, Stuart DD. PMID: 23302800.
      View in: PubMed   Mentions: 250     Fields:    Translation:HumansAnimalsCells
    38. Elucidating distinct roles for NF1 in melanomagenesis. Cancer Discov. 2013 Mar; 3(3):338-49. Maertens O, Johnson B, Hollstein P, Frederick DT, Cooper ZA, Messiaen L, Bronson RT, McMahon M, Granter S, Flaherty K, Wargo JA, Marais R, Cichowski K. PMID: 23171796.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    39. Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma. J Pathol. 2013 Jan; 229(1):132-40. Mito JK, Min HD, Ma Y, Carter JE, Brigman BE, Dodd L, Dankort D, McMahon M, Kirsch DG. PMID: 22951975.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    40. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature. 2012 Nov 15; 491(7424):449-53. Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, Bosenberg MW, Haigis KM, Haber DA, Wang Y, Fisher DE. PMID: 23123854.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    41. The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes Dev. 2012 Sep 01; 26(17):1945-58. Andreadi C, Cheung LK, Giblett S, Patel B, Jin H, Mercer K, Kamata T, Lee P, Williams A, McMahon M, Marais R, Pritchard C. PMID: 22892241.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    42. B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer. Cancer Res. 2012 Sep 15; 72(18):4765-76. Wang J, Kobayashi T, Floc'h N, Kinkade CW, Aytes A, Dankort D, Lefebvre C, Mitrofanova A, Cardiff RD, McMahon M, Califano A, Shen MM, Abate-Shen C. PMID: 22836754.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    43. Analysis of mRNA profiles after MEK1/2 inhibition in human pancreatic cancer cell lines reveals pathways involved in drug sensitivity. Mol Cancer Res. 2012 Dec; 10(12):1607-19. Gysin S, Paquette J, McMahon M. PMID: 22833572.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    44. Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development. 2012 Jul; 139(14):2477-87. Tien AC, Tsai HH, Molofsky AV, McMahon M, Foo LC, Kaul A, Dougherty JD, Heintz N, Gutmann DH, Barres BA, Rowitch DH. PMID: 22675209.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    45. A central role for RAF?MEK?ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Cancer Discov. 2012 Aug; 2(8):685-93. Collisson EA, Trejo CL, Silva JM, Gu S, Korkola JE, Heiser LM, Charles RP, Rabinovich BA, Hann B, Dankort D, Spellman PT, Phillips WA, Gray JW, McMahon M. PMID: 22628411.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    46. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8710-5. Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH. PMID: 22586120.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    47. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. Genes Dev. 2012 May 15; 26(10):1055-69. Vredeveld LC, Possik PA, Smit MA, Meissl K, Michaloglou C, Horlings HM, Ajouaou A, Kortman PC, Dankort D, McMahon M, Mooi WJ, Peeper DS. PMID: 22549727.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    48. E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor. Dev Biol. 2012 Jun 15; 366(2):357-66. Li CY, Cha W, Luder HU, Charles RP, McMahon M, Mitsiadis TA, Klein OD. PMID: 22537490.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    49. MEK1/2 inhibition elicits regression of autochthonous lung tumors induced by KRASG12D or BRAFV600E. Cancer Res. 2012 Jun 15; 72(12):3048-59. Trejo CL, Juan J, Vicent S, Sweet-Cordero A, McMahon M. PMID: 22511580.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    50. ß-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell. 2011 Dec 13; 20(6):741-54. Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Gould Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. PMID: 22172720.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    51. Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science. 2011 Jul 15; 333(6040):342-345. Tang N, Marshall WF, McMahon M, Metzger RJ, Martin GR. PMID: 21764747.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    52. Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse. Cancer Res. 2011 Jun 01; 71(11):3863-71. Charles RP, Iezza G, Amendola E, Dankort D, McMahon M. PMID: 21512141.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    53. Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies. Am J Med Genet C Semin Med Genet. 2011 May 15; 157C(2):136-46. Rauen KA, Banerjee A, Bishop WR, Lauchle JO, McCormick F, McMahon M, Melese T, Munster PN, Nadaf S, Packer RJ, Sebolt-Leopold J, Viskochil DH. PMID: 21495172.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    54. Parsing out the complexity of RAF inhibitor resistance. Pigment Cell Melanoma Res. 2011 Apr; 24(2):361-5. McMahon M. PMID: 21392366.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    55. RAF translocations expand cancer targets. Nat Med. 2010 Jul; 16(7):749-50. McMahon M. PMID: 20613748.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    56. Resiliency and vulnerability in the HER2-HER3 tumorigenic driver. Sci Transl Med. 2010 Jan 27; 2(16):16ra7. Amin DN, Sergina N, Ahuja D, McMahon M, Blair JA, Wang D, Hann B, Koch KM, Shokat KM, Moasser MM. PMID: 20371474.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    57. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. . 2010 Jan; 152A(1):4-24. Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. PMID: 20014119.
      View in: PubMed   Mentions:
    58. Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010 Jan 01; 70(1):388-97. Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW. PMID: 20048081.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    59. Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway. Cell Signal. 2009 Dec; 21(12):1846-56. Krueger F, Madeja Z, Hemberger M, McMahon M, Cook SJ, Gaunt SJ. PMID: 19686845.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    60. Meeting report: consensus from the first and second Global Workshops in Melanoma November 19-20, 2008. Pigment Cell Melanoma Res. 2009 Oct; 22(5):532-43. Agarwala SS, Becker JC, Eggermont AM, Flaherty KT, Garbe C, Goldstein AM, Halpern A, Kashani-Sabet M, Hauschild A, Kirkwood JM, Leachman S, Lorigan P, McMahon M, Messina J, Ribas A, Samlowski WE, Schadendorf D, Sondak VK. PMID: 19659612.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    61. Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet. 2009 May; 41(5):544-52. Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE, You MJ, DePinho RA, McMahon M, Bosenberg M. PMID: 19282848.
      View in: PubMed   Mentions: 409     Fields:    Translation:AnimalsCells
    62. Meeting report: fourth international congress of the Society for Melanoma Research. Pigment Cell Melanoma Res. 2008 Feb; 21(1):15-26. Fisher DE, Medrano EE, McMahon M, Soengas MS, Schuchter L, Wolchok JD, Merlino G. PMID: 18353140.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    63. Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival. Pigment Cell Melanoma Res. 2008 Oct; 21(5):534-44. Cartlidge RA, Thomas GR, Cagnol S, Jong KA, Molton SA, Finch AJ, McMahon M. PMID: 18715233.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    64. A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev. 2007 Feb 15; 21(4):379-84. Dankort D, Filenova E, Collado M, Serrano M, Jones K, McMahon M. PMID: 17299132.
      View in: PubMed   Mentions: 182     Fields:    Translation:Animals
    65. A model of intussusceptive angiogenesis. Novartis Found Symp. 2007; 283:37-42; discussion 42-5, 238-41. Levin M, Ewald AJ, McMahon M, Werb Z, Mostov K. PMID: 18300412.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    66. Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3274-9. Banerjee A, Gugasyan R, McMahon M, Gerondakis S. PMID: 16484370.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    67. Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer Res. 2005 Nov 01; 65(21):9643-50. Brandts CH, Sargin B, Rode M, Biermann C, Lindtner B, Schwäble J, Buerger H, Müller-Tidow C, Choudhary C, McMahon M, Berdel WE, Serve H. PMID: 16266983.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    68. Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines. Genes Chromosomes Cancer. 2005 Sep; 44(1):37-51. Gysin S, Rickert P, Kastury K, McMahon M. PMID: 15929091.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    69. Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines. . 2005 Jun; 4(6):822-30. Shelton JG, Steelman LS, Abrams SL, White ER, Akula SM, Franklin RA, Bertrand FE, McMahon M, McCubrey JA. PMID: 15917660.
      View in: PubMed   Mentions:
    70. Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1. Cancer Res. 2005 Jun 01; 65(11):4870-80. Gysin S, Lee SH, Dean NM, McMahon M. PMID: 15930308.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    71. Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. Mol Cell Biol. 2005 Jan; 25(1):220-32. Sreeramaneni R, Chaudhry A, McMahon M, Sherr CJ, Inoue K. PMID: 15601844.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    72. Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Mol Cell Biol. 2004 Dec; 24(24):10868-81. Mirza AM, Gysin S, Malek N, Nakayama K, Roberts JM, McMahon M. PMID: 15572689.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    73. Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells. Oncogene. 2004 Oct 14; 23(47):7810-20. McCubrey JA, Shelton JG, Steelman LS, Franklin RA, Sreevalsan T, McMahon M. PMID: 15361836.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    74. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J Biol Chem. 2004 Jul 09; 279(28):28880-8. Silletti S, Yebra M, Perez B, Cirulli V, McMahon M, Montgomery AM. PMID: 15128735.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    75. Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest. 2004 Feb; 113(4):539-50. Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG. PMID: 14966563.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    76. DeltaRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry. Mol Cell Biol. 2003 Dec; 23(24):9303-17. Balmanno K, Millar T, McMahon M, Cook SJ. PMID: 14645540.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    77. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003 Oct 23; 425(6960):851-6. Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernández-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw AL, Hebrok M. PMID: 14520413.
      View in: PubMed   Mentions: 481     Fields:    Translation:HumansAnimalsCells
    78. Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway. Exp Cell Res. 2003 Jul 15; 287(2):325-38. Woodrow MA, Woods D, Cherwinski HM, Stokoe D, McMahon M. PMID: 12837288.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    79. Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells. Cancer Res. 2003 May 01; 63(9):2088-95. Anders M, Christian C, McMahon M, McCormick F, Korn WM. PMID: 12727824.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    80. Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells. Oncogene. 2003 Apr 24; 22(16):2478-92. Shelton JG, Steelman LS, Lee JT, Knapp SL, Blalock WL, Moye PW, Franklin RA, Pohnert SC, Mirza AM, McMahon M, McCubrey JA. PMID: 12717425.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    81. De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. J Virol. 2002 Mar; 76(5):2440-8. Lagunoff M, Bechtel J, Venetsanakos E, Roy AM, Abbey N, Herndier B, McMahon M, Ganem D. PMID: 11836422.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansCells
    82. Induction of tubulogenesis in telomerase-immortalized human microvascular endothelial cells by glioblastoma cells. Exp Cell Res. 2002 Feb 01; 273(1):21-33. Venetsanakos E, Mirza A, Fanton C, Romanov SR, Tlsty T, McMahon M. PMID: 11795943.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
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