Andrew Mendiola, PhD

Title(s)Visiting Scientist, Business Service Ctr
SchoolChancellor/EVC/FAS
PronounsHe/Him/His
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    Collapse Biography 
    Collapse Education and Training
    University of Texas at San AntonioPh.D.05/2017Cell & Molecular Biology
    Gladstone Institutes, UCSFPostdocNeuroimmunology
    Collapse Awards and Honors
    National MS Society2018  - 2021Postdoctoral Fellowship
    Aegean Confences: 16th Intl Conf on Innate Immunity2019Oral Presentation Award
    University of California, San Francisco2017  - 2018Immunology T32 Postdoc Fellowship
    American Society for Neurochemistry2017ASNeuro Travel Award
    University of Texas, San Antonio2016  - 2017Presidential Dissertation Fellowship
    American Association for Immunologist2016Trainee Poster Award
    University of Texas, San Antonio2016Best Grad Student Presentation for Immunology
    University of Texas, San Antonio2015Best Grad Student Presentation for Immunology
    Retina Research Foundation/ARVO2015Travel Award
    UTSA, NIH2013  - 2017RISE Predoctoral Fellowship

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Epigenomic regulation of oxidative stress-producing innate immunity in neuroinflammation
    NIH/NINDS 1K99NS126707-01Apr 15, 2022 - Mar 31, 2024
    Role: PI
    In vivo imaging and profiling of mechanisms of T-cell recruitment and activation during neuroinflammation
    National Multiple Sclerosis Society FG-1708-28925Jul 1, 2018 - Jul 1, 2021
    Role: Principle Investigator
    Functional profiling of ligand-selective activation of complement receptor 3 in macrophages
    NIH/NIAID UCSF Immunology T32 AI007334Aug 1, 2017 - Jun 30, 2018
    Role: Trainee

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models. Cell Rep. 2024 Oct 19; 43(11):114870. Miller SR, Luxem K, Lauderdale K, Nambiar P, Honma PS, Ly KK, Bangera S, Bullock M, Shin J, Kaliss N, Qiu Y, Cai C, Shen K, Mallen KD, Yan Z, Mendiola AS, Saito T, Saido TC, Pico AR, Thomas R, Roberson ED, Akassoglou K, Bauer P, Remy S, Palop JJ. PMID: 39427315.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Pioneering discovery and therapeutics at the brain-vascular-immune interface. Cell. 2024 Oct 17; 187(21):5871-5876. Akassoglou K, Davalos D, Mendiola AS, Petersen MA, Ryu JK, Schachtrup C, Yan Z. PMID: 39423805.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    3. Fibrin drives thromboinflammation and neuropathology in COVID-19. Nature. 2024 Sep; 633(8031):905-913. Ryu JK, Yan Z, Montano M, Sozmen EG, Dixit K, Suryawanshi RK, Matsui Y, Helmy E, Kaushal P, Makanani SK, Deerinck TJ, Meyer-Franke A, Rios Coronado PE, Trevino TN, Shin MG, Tognatta R, Liu Y, Schuck R, Le L, Miyajima H, Mendiola AS, Arun N, Guo B, Taha TY, Agrawal A, MacDonald E, Aries O, Yan A, Weaver O, Petersen MA, Meza Acevedo R, Alzamora MDPS, Thomas R, Traglia M, Kouznetsova VL, Tsigelny IF, Pico AR, Red-Horse K, Ellisman MH, Krogan NJ, Bouhaddou M, Ott M, Greene WC, Akassoglou K. PMID: 39198643; PMCID: PMC11424477.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    4. Fibrin promotes oxidative stress and neuronal loss in traumatic brain injury via innate immune activation. J Neuroinflammation. 2024 Apr 15; 21(1):94. Dean T, Mendiola AS, Yan Z, Meza-Acevedo R, Cabriga B, Akassoglou K, Ryu JK. PMID: 38622640; PMCID: PMC11017541.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    5. Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat Immunol. 2023 07; 24(7):1173-1187. Mendiola AS, Yan Z, Dixit K, Johnson JR, Bouhaddou M, Meyer-Franke A, Shin MG, Yong Y, Agrawal A, MacDonald E, Muthukumar G, Pearce C, Arun N, Cabriga B, Meza-Acevedo R, Alzamora MDPS, Zamvil SS, Pico AR, Ryu JK, Krogan NJ, Akassoglou K. PMID: 37291385; PMCID: PMC10307624.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    6. Pharmacological depletion of microglia alleviates neuronal and vascular damage in the diabetic CX3CR1-WT retina but not in CX3CR1-KO or hCX3CR1I249/M280-expressing retina. Front Immunol. 2023; 14:1130735. Church KA, Rodriguez D, Mendiola AS, Vanegas D, Gutierrez IL, Tamayo I, Amadu A, Velazquez P, Cardona SM, Gyoneva S, Cotleur AC, Ransohoff RM, Kaur T, Cardona AE. PMID: 37033925; PMCID: PMC10077890.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. Defective fractalkine-CX3CR1 signaling aggravates neuroinflammation and affects recovery from cuprizone-induced demyelination. J Neurochem. 2022 09; 162(5):430-443. Mendiola AS, Church KA, Cardona SM, Vanegas D, Garcia SA, Macklin W, Lira SA, Ransohoff RM, Kokovay E, Lin CA, Cardona AE. PMID: 35560167; PMCID: PMC9427683.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    8. Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner. ASN Neuro. 2022 Jan-Dec; 14:17590914221131446. Sarker B, Cardona SM, Church KA, Vanegas D, Velazquez P, Rorex C, Rodriguez D, Mendiola AS, Kern TS, Domingo ND, Stephens R, Muzzio IA, Cardona AE. PMID: 36221892; PMCID: PMC9557863.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    9. BMP receptor blockade overcomes extrinsic inhibition of remyelination and restores neurovascular homeostasis. Brain. 2021 09 04; 144(8):2291-2301. Petersen MA, Tognatta R, Meyer-Franke A, Bushong EA, Mendiola AS, Yan Z, Muthusamy A, Merlini M, Meza-Acevedo R, Cabriga B, Zhou Y, Thomas R, Ryu JK, Lassmann H, Ellisman MH, Akassoglou K. PMID: 34426831; PMCID: PMC8418337.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    10. ApoE and immunity in Alzheimer's disease and related tauopathies: Low-density lipoprotein receptor to the rescue. Neuron. 2021 08 04; 109(15):2363-2365. Mendiola AS, Tognatta R, Yan Z, Akassoglou K. PMID: 34352209; PMCID: PMC8546493.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Blood Coagulation Factor Fibrinogen in Tumor Pathogenesis of Central Nervous System B-Cell Lymphoma. Am J Pathol. 2021 03; 191(3):575-583. Chan JP, Merlini M, Gao HX, Mendiola AS, Akassoglou K, Rubenstein JL, Ryu JK. PMID: 33608067; PMCID: PMC7919853.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    12. Microglial Gi-dependent dynamics regulate brain network hyperexcitability. Nat Neurosci. 2021 01; 24(1):19-23. Merlini M, Rafalski VA, Ma K, Kim KY, Bushong EA, Rios Coronado PE, Yan Z, Mendiola AS, Sozmen EG, Ryu JK, Haberl MG, Madany M, Sampson DN, Petersen MA, Bardehle S, Tognatta R, Dean T, Acevedo RM, Cabriga B, Thomas R, Coughlin SR, Ellisman MH, Palop JJ, Akassoglou K. PMID: 33318667; PMCID: PMC8118167.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    13. Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 Sep; 21(9):1135. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Coronado PER, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32661365.
      View in: PubMed   Mentions: 2     Fields:    
    14. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nat Immunol. 2020 05; 21(5):513-524. Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, Tognatta R, Yan Z, Pfaff SJ, Machado MR, Bedard C, Rios Coronado PE, Jiang X, Wang J, Pleiss MA, Green AJ, Zamvil SS, Pico AR, Bruneau BG, Arkin MR, Akassoglou K. PMID: 32284594; PMCID: PMC7523413.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    15. Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis. Proc Natl Acad Sci U S A. 2019 05 21; 116(21):10488-10493. Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ. PMID: 31068461; PMCID: PMC6535008.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    16. Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant. Front Cell Neurosci. 2018; 12:365. Cardona SM, Kim SV, Church KA, Torres VO, Cleary IA, Mendiola AS, Saville SP, Watowich SS, Parker-Thornburg J, Soto-Ospina A, Araque P, Ransohoff RM, Cardona AE. PMID: 30386211; PMCID: PMC6199958.
      View in: PubMed   Mentions: 30  
    17. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nat Immunol. 2018 11; 19(11):1212-1223. Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, Machado MR, Chan JP, Plastira I, Petersen MA, Pfaff SJ, Ang KK, Hallenbeck KK, Syme C, Hakozaki H, Ellisman MH, Swanson RA, Zamvil SS, Arkin MR, Zorn SH, Pico AR, Mucke L, Freedman SB, Stavenhagen JB, Nelson RB, Akassoglou K. PMID: 30323343; PMCID: PMC6317891.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimals
    18. Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage. Neuron. 2017 Dec 06; 96(5):1003-1012.e7. Petersen MA, Ryu JK, Chang KJ, Etxeberria A, Bardehle S, Mendiola AS, Kamau-Devers W, Fancy SPJ, Thor A, Bushong EA, Baeza-Raja B, Syme CA, Wu MD, Rios Coronado PE, Meyer-Franke A, Yahn S, Pous L, Lee JK, Schachtrup C, Lassmann H, Huang EJ, Han MH, Absinta M, Reich DS, Ellisman MH, Rowitch DH, Chan JR, Akassoglou K. PMID: 29103804; PMCID: PMC5851281.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    19. The IL-1β phenomena in neuroinflammatory diseases. J Neural Transm (Vienna). 2018 05; 125(5):781-795. Mendiola AS, Cardona AE. PMID: 28534174; PMCID: PMC5699978.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimals
    20. Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy. Front Cell Neurosci. 2016; 10:303. Mendiola AS, Garza R, Cardona SM, Mythen SA, Lira SA, Akassoglou K, Cardona AE. PMID: 28119571; PMCID: PMC5222852.
      View in: PubMed   Mentions: 25  
    21. TGFβ induces BIGH3 expression and human retinal pericyte apoptosis: a novel pathway of diabetic retinopathy. Eye (Lond). 2016 Dec; 30(12):1639-1647. Betts-Obregon BS, Mondragon AA, Mendiola AS, LeBaron RG, Asmis R, Zou T, Gonzalez-Fernandez F, Tsin AT. PMID: 27564721; PMCID: PMC5177749.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    22. Antifungal Activity of Plasmacytoid Dendritic Cells against Cryptococcus neoformans In Vitro Requires Expression of Dectin-3 (CLEC4D) and Reactive Oxygen Species. Infect Immun. 2016 09; 84(9):2493-504. Hole CR, Leopold Wager CM, Mendiola AS, Wozniak KL, Campuzano A, Lin X, Wormley FL. PMID: 27324480; PMCID: PMC4995896.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    23. Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina. ASN Neuro. 2015 Sep-Oct; 7(5). Cardona SM, Mendiola AS, Yang YC, Adkins SL, Torres V, Cardona AE. PMID: 26514658; PMCID: PMC4641555.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    24. The role of microglia in diabetic retinopathy. J Ophthalmol. 2014; 2014:705783. Grigsby JG, Cardona SM, Pouw CE, Muniz A, Mendiola AS, Tsin AT, Allen DM, Cardona AE. PMID: 25258680; PMCID: PMC4166427.
      View in: PubMed   Mentions: 89  
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